Xiaonan Han, Mingkang Zhang, Liyan Yan, Yikun Fu, Hongwei Kou, Chunfeng Shang, Junmin Wang, Hongjian Liu, Chao Jiang, Jian Wang, Tian Cheng
BACKGROUND: Inflammation can worsen spinal cord injury (SCI), with dendritic cells (DCs) playing a crucial role in the inflammatory response. They mediate T lymphocyte differentiation, activate microglia, and release cytokines like NT-3. Moreover, DCs can promote neural stem cell survival and guide them toward neuron differentiation, positively impacting SCI outcomes. OBJECTIVE: This review aims to summarize the role of DCs in SCI-related inflammation and identify potential therapeutic targets for treating SCI...
March 2024: CNS Neuroscience & Therapeutics