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CNS Neuroscience & Therapeutics

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https://www.readbyqxmd.com/read/29345116/notch1-gain-of-function-in-skeletal-muscles-leads-to-neuromuscular-junction-formation-defects-and-neonatal-death
#1
LETTER
Hai-Hong Yang, Feng-Jiao Liu, Yan Wu, Qian Zhu, Juan-Xian Cheng, Ming Fan, Hai-Tao Wu
No abstract text is available yet for this article.
January 17, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29345054/isoflurane-anesthesia-in-aged-mice-and-effects-of-a1-adenosine-receptors-on-cognitive-impairment
#2
Chun-Long Zuo, Chun-Man Wang, Jin Liu, Ting Shen, Jiang-Ping Zhou, Xin-Rui Hao, Yi-Zhao Pan, Hua-Cheng Liu, Qing-Quan Lian, Han Lin
AIMS: Isoflurane may not only accelerate the process of Alzheimer's disease (AD), but increase the risk of incidence of postoperative cognitive dysfunction (POCD). However, the underlying mechanisms remain unknown. This study was designed to investigate whether isoflurane contributed to the POCD occurrence through A1 adenosine receptor (A1AR) in aged mice. METHODS: We assessed cognitive function of mice with Morris water maze (MWM) and then measured expression level of two AD biomarkers (P-tau and Aβ) and a subtype of the NMDA receptor (NR2B) in aged wild-type (WT) and homozygous A1 adenosine receptor (A1AR) knockout (KO) mice at baseline and after they were exposed to isoflurane (1...
January 17, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29336114/nucleolar-and-spindle-associated-protein-1-is-a-tumor-grade-correlated-prognosis-marker-for-glioma-patients
#3
Tao Zhu, Pan Xie, Yuan-Feng Gao, Ma-Sha Huang, Xi Li, Wei Zhang, Hong-Hao Zhou, Zhao-Qian Liu
AIMS: Despite therapeutic advances in glioma management including surgery, radiation, and chemotherapy, the improvement of patient outcome is far from satisfactory. Nucleolar and spindle-associated protein 1 (NUSAP1) is an important functional protein during mitosis, and its abnormal expression is implicated in progression of different types of tumors. However, the role of NUSAP1 in gliomas remains unclear. METHODS: NUSAP1 expression in gliomas with different grades was investigated based on GEO glioma datasets...
January 15, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29318784/divalproex-sodium-modulates-nuclear-localization-of-ataxin-3-and-prevents-cellular-toxicity-caused-by-expanded-ataxin-3
#4
Zi-Jian Wang, Aoife Hanet, Daniel Weishäupl, Inês M Martins, Anna S Sowa, Olaf Riess, Thorsten Schmidt
BACKGROUND & AIMS: Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), is an autosomal dominantly inherited neurodegenerative disorder and the most common form of SCA worldwide. It is caused by the expansion of a polyglutamine (polyQ) tract in the ataxin-3 protein. Nuclear localization of the affected protein is a key event in the pathology of SCA3 via affecting nuclear organization, transcriptional dysfunction, and seeding aggregations, finally causing neurodegeneration and cell death...
January 9, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29318783/tak-063-a-novel-pde10a-inhibitor-with-balanced-activation-of-direct-and-indirect-pathways-provides-a-unique-opportunity-for-the-treatment-of-schizophrenia
#5
REVIEW
Kazunori Suzuki, Haruhide Kimura
The basal ganglia regulates motor, cognitive, and emotional behaviors. Dysfunction of dopamine system in this area is implicated in the pathophysiology of schizophrenia characterized by positive symptoms, negative symptoms, and cognitive deficits. Medium spiny neurons (MSNs) are principal output neurons of striatum in the basal ganglia. Similar to current antipsychotics with dopamine D2 receptor antagonism or partial agonism, phosphodiesterase 10A (PDE10A) inhibitors activate indirect pathway MSNs, leading to the expectation of therapeutic potential for the treatment of psychosis...
January 9, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29318747/the-caudal-part-of-the-posterior-insula-of-rats-participates-in-the-maintenance-but-not-the-acquisition-of-morphine-conditioned-place-preference
#6
Yong-Mei Sun, Rong-Xiang Chen, Zhi-Fei Li, Sabine Spijker, Rong-Wei Zhai, Shang-Chuan Yang
The heterogeneous insular cortex plays an interoceptive role in drug addiction by signaling the availability of drugs of abuse. Here, we tested whether the caudal part of the multisensory posterior insula (PI) stores somatosensory-associated rewarding memories. Using Sprague Dawley rats as subjects, we first established a morphine-induced conditioned place preference (CPP) paradigm, mainly based on somatic cues. Secondly, an electrolytic lesion of the caudal portion of the PI was carried out before and after the establishment of CPP, respectively...
January 9, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29316313/microrna-21-promotes-glioma-cell-proliferation-and-inhibits-senescence-and-apoptosis-by-targeting-spry1-via-the-pten-pi3k-akt-signaling-pathway
#7
Chang Chai, Lai-Jun Song, Shuang-Yin Han, Xi-Qing Li, Ming Li
AIMS: Our study aims to investigate the effect of microRNA-21 (miR-21) on the proliferation, senescence, and apoptosis of glioma cells by targeting SPRY1 via the PTEN/PI3K/AKT signaling pathway. METHODS: Glioma tissues and brain tissues were collected for this study after surgical decompression for traumatic brain injury. RT-qPCR was employed to measure mRNA levels of miR-21, SPRY1, PTEN, PI3K, and AKT, and Western blotting was conducted to determine protein levels of SPRY1, PTEN, PI3K, AKT, p-AKT, Caspase-3, Caspase-9, P53, GSK3, and p-GSK3...
January 5, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29316271/fingolimod-improved-axonal-and-myelin-integrity-of-white-matter-tracts-associated-with-multiple-sclerosis-related-functional-impairments
#8
Michael Gurevich, Roy Waknin, Evan Stone, Anat Achiron
AIMS: Fingolimod hydrochloride is an effective immunomodulatory drug in improving relapsing-remitting multiple sclerosis (RRMS). However, data on the neuroradiologic effects on white matter (WM) have not been demonstrated. In this study, we aimed elucidating the impact of 1-year fingolimod treatment on WM integrity in patients with RRMS. METHODS: Diffusion tensor imaging (DTI) was applied to assess axonal and myelin integrity in specific WM tracts of patients with RRMS prior to and 1 year postfingolimod treatment (n = 30)...
January 5, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29314714/behavioral-fragmentation-in-the-d1ct-7-mouse-model-of-tourette-s-syndrome
#9
Andrea Santangelo, Marco Bortolato, Laura J Mosher, Giuseppe Crescimanno, Giuseppe Di Giovanni, Emanuele Cassioli, Valdo Ricca, Maurizio Casarrubea
AIM: The transgenic D1CT-7 mouse is one of the best-characterized animal models of Tourette's syndrome (TS), exhibiting spontaneous tic-like Head-Body Twitches (HBT) and deficits in sensorimotor gating. This study is aimed at evaluating the behavioral dynamics of these mutants and their potential relevance to TS. METHODS: The behavior of D1CT-7 and Wild Type littermates was firstly assessed by considering frequencies and durations. To detect recurrent real-time behavioral sequences, the multivariate T-pattern analysis was employed...
January 3, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29314605/transcriptome-profiling-of-peripheral-blood-immune-cell-populations-in-multiple-sclerosis-patients-before-and-during-treatment-with-a-sphingosine-1-phosphate-receptor-modulator
#10
Ines C Angerer, Michael Hecker, Dirk Koczan, Luisa Roch, Jörg Friess, Annelen Rüge, Brit Fitzner, Nina Boxberger, Ina Schröder, Kristin Flechtner, Hans-Jürgen Thiesen, Alexander Winkelmann, Stefanie Meister, Uwe K Zettl
AIMS: Fingolimod is a sphingosine-1-phosphate (S1P) receptor modulator approved for the treatment of the relapsing form of multiple sclerosis (MS). It prevents the egress of lymphocyte subpopulations from lymphoid tissues into the circulation. Here, we explored the broad effects of fingolimod on gene expression in different immune cell subsets. METHODS: Utilizing 150 high-resolution microarrays from Affymetrix, we obtained the transcriptome profiles of 5 cell populations, which were separated from the peripheral blood of MS patients prior to and following oral administration of fingolimod...
January 3, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29293287/visual-field-impairment-predicts-recurrent-stroke-after-acute-posterior-circulation-stroke-and-transient-ischemic-attack
#11
Yi-Ming Deng, Duan-Duan Chen, Lu-Yao Wang, Feng Gao, Xuan Sun, Lian Liu, Kun Lei, Shu-Ran Wang, Da-Peng Mo, Ning Ma, Li-Gang Song, Xiao-Chuan Huo, Xiao-Tong Xu, Tian-Yi Yan, Zhong-Rong Miao
AIMS: To evaluate whether visual field impairment (VFI) can predict stroke recurrence in patients with vertebral-basilar (VB) stroke. METHODS: A total of 326 patients were eligible for a VFI evaluation within 1 week of stroke onset. One-year follow-up data were obtained after VB stroke and other vascular events. All predictors were determined using Cox regression models. RESULTS: The overall incidence of recurrent VB stroke and transient ischemic attack (TIA) was 29% (n = 92)...
January 2, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29285884/two-year-observational-study-of-deferiprone-in-superficial-siderosis
#12
Remi A Kessler, Xu Li, Kateryna Schwartz, Hwa Huang, Maureen A Mealy, Michael Levy
INTRODUCTION: Superficial siderosis is a rare, neurodegenerative disease caused by toxic accumulation of hemosiderin on the surface of the brain and the spinal cord, most commonly from chronic subarachnoid hemorrhage. AIMS: The aim of this study was to assess the clinical and radiological outcomes of superficial siderosis patients using deferiprone, a cell permeant iron chelator. Subjects obtained pre- and post-treatment brain MRIs and weekly laboratory tests. Osirix software was used to develop a method of quantifying hemosiderin deposition...
December 28, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29274300/unconjugated-bilirubin-modulates-neuronal-signaling-only-in-wild-type-mice-but-not-after-ablation-of-the-r-type-cav-2-3-voltage-gated-calcium-channel
#13
Walid Albanna, Felix Neumaier, Jan Niklas Lüke, Konstantin Kotliar, Catharina Conzen, Ute Lindauer, Jürgen Hescheler, Hans Clusmann, Toni Schneider, Gerrit Alexander Schubert
INTRODUCTION: The relationship between blood metabolites and hemoglobin degradation products (BMHDPs) formed in the cerebrospinal fluid and the development of vasospasm and delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH) has been the focus of several previous studies, but their molecular and cellular targets remain to be elucidated. METHODS: Because BMHDP-induced changes in Cav 2.3 channel function are thought to contribute to DCI after aSAH, we studied their modulation by unconjugated bilirubin (UCB) in an organotypical neuronal network from wild-type (WT) and Cav 2...
December 23, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29274291/enriched-physical-environment-reverses-spatial-cognitive-impairment-of-socially-isolated-appswe-ps1de9-transgenic-mice-before-amyloidosis-onset
#14
Min Cao, Pan-Pan Hu, Yan-Li Zhang, Yi-Xin Yan, Christopher B Shields, Yi-Ping Zhang, Gang Hu, Ming Xiao
AIMS: Social isolation increases the onset of Alzheimer's disease (AD). Environmental enrichment, a complicated social and physical construct, plays beneficial effects on brain plasticity and function. This study was designed to determine whether physical enrichment can reduce the deleterious consequences of social isolation on the onset of AD. METHODS: One-month-old APPswe/PS1dE9 transgenic AD model mice were singly housed in the enriched physical environment for 8 weeks and then received behavioral tests, neuropathological analyses, and Western blot of the hippocampus...
December 23, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29266758/the-neurobiological-mechanisms-of-physical-exercise-in-methamphetamine-addiction
#15
REVIEW
António Pedro Delgado Morais, Inês Roque Pita, Carlos Alberto Fontes-Ribeiro, Frederico Costa Pereira
Methamphetamine (METH) is the primary drug within amphetamine-type stimulants which are the second most abused group of drugs worldwide. There is no pharmacological treatment addressed specifically to METH addiction, and behavioral therapy is shadowed by poor long-term recovery and relapse. Therefore, novel approaches to manage METH addiction are an urgent need. This review aims to describe the current state of physical exercise use on methamphetamine addiction management. The following searching terms in PubMed were used: ("physical exercise" OR "exercise") AND "methamphetamine...
December 20, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29222835/effective-network-of-deep-brain-stimulation-of-subthalamic-nucleus-with-bimodal-positron-emission-tomography-functional-magnetic-resonance-imaging-in-parkinson-s-disease
#16
Hui-Min Chen, Zhi-Qiang Sha, Hui-Zi Ma, Yong He, Tao Feng
AIMS: Deep brain stimulation of the subthalamic nucleus (STN-DBS) has become an effective treatment strategy for patients with Parkinson's disease. However, the biological mechanism underlying DBS treatment remains poorly understood. METHOD: In this study, we investigated how STN-DBS modulated the brain network using a bimodal positron emission tomography (PET)/functional magnetic resonance imaging (fMRI) dataset. We first performed an activation likelihood estimation meta-analysis of 13 PET/SPECT studies concerning STN-DBS effects on resting-state brain activity in Parkinson's disease...
December 8, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29214729/finasteride-inhibited-brain-dopaminergic-system-and-open-field-behaviors-in-adolescent-male-rats
#17
Li Li, Yun-Xiao Kang, Xiao-Ming Ji, Ying-Kun Li, Shuang-Cheng Li, Xiang-Jian Zhang, Hui-Xian Cui, Ge-Ming Shi
AIMS: Finasteride inhibits the conversion of testosterone to dihydrotestosterone. Because androgen regulates dopaminergic system in the brain, it could be hypothesized that finasteride may inhibit dopaminergic system. The present study therefore investigates the effects of finasteride in adolescent and early developmental rats on dopaminergic system, including contents of dopamine and its metabolites (dihydroxy phenyl acetic acid and homovanillic acid) and tyrosine hydroxylase expressions both at gene and protein levels...
December 6, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29205833/monocarboxylate-transporter-1-and-the-vulnerability-of-oligodendrocyte-lineage-cells-to-metabolic-stresses
#18
Peng Zhou, Teng Guan, Zhao Jiang, Mike Namaka, Qing-Jun Huang, Ji-Ming Kong
AIMS: Oligodendrocytes, especially oligodendrocyte precursor cells, are known to be sensitive to hypoxic and metabolic stresses. Vulnerability of oligodendrocytes is considered a contributing factor to white matter dysfunction. However, little is known about the energy processing characteristics of oligodendrocyte lineage cells under basal and metabolic stress conditions. The aim of this study was to identify the energy requirements and cellular responses of oligodendrocytes at different developmental stages...
December 4, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29171169/no-effect-of-transcranial-direct-current-stimulation-of-the-dorsolateral-prefrontal-cortex-on-short-term-memory
#19
Jing Wang, Jianbing Wen, Xiaoli Li
INTRODUCTION: Short-term memory refers to the capacity for holding information in mind for a short period of time with conscious memorization. It is an important ability for daily life and is impaired in several neurological and psychiatric disorders. Anodal transcranial direct current stimulation (tDCS) applied to the dorsolateral prefrontal cortex (DLPFC) was reported to enhance the capability of short-term memory in healthy subjects. However, results were not consistent and what is the possible impact factor is not known...
November 23, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29143496/does-the-serotonin2c-receptor-segregate-circuits-of-the-basal-ganglia-responding-to-cingulate-cortex-stimulation
#20
LETTER
Mélanie Lagière, Marion Bosc, Sara Whitestone, Julien Manem, Hasna Elboukhari, Abdelhamid Benazzouz, Giuseppe Di Giovanni, Philippe De Deurwaerdère
No abstract text is available yet for this article.
November 15, 2017: CNS Neuroscience & Therapeutics
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