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CNS Neuroscience & Therapeutics

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https://www.readbyqxmd.com/read/28195427/oculomotor-deficits-in-spinocerebellar-ataxia-type-3-potential-biomarkers-of-preclinical-detection-and-disease-progression
#1
Chao Wu, Ding-Bang Chen, Li Feng, Xiang-Xue Zhou, Ji-Wei Zhang, Hua-Jing You, Xiu-Ling Liang, Zhong Pei, Xun-Hua Li
AIMS: To detect specific oculomotor deficits in preclinical stage of spinocerebellar ataxia type 3 (SCA3) and evaluate whether these abnormalities prove useful as potential biomarkers of disease progression. METHODS: A Chinese cohort of 56 patients with SCA3, including 12 preclinical carriers of SCA3 (pre-SCA3) and 44 manifest SCA3, and 26 healthy control individuals were recruited. We performed a detailed investigation on central oculomotor performance including fixation, gaze, smooth pursuit, prosaccade, and antisaccade using video-oculography...
February 13, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28191738/the-role-of-neuroinflammation-and-amyloid-in-cognitive-impairment-in-an-app-ps1-transgenic-mouse-model-of-alzheimer-s-disease
#2
Shenghua Zhu, Junhui Wang, Yanbo Zhang, Jue He, Jiming Kong, Jun-Feng Wang, Xin-Min Li
AIMS: Both amyloid deposition and neuroinflammation appear in the early course of Alzheimer's disease (AD). However, the progression of neuroinflammation and its relationship with amyloid deposition and behavioral changes have not been fully elucidated. A better understanding the role of neuroinflammation in AD might extend our current knowledge to therapeutic intervention possibilities. METHODS: This study systematically characterized changes in behavioral abnormalities in APP/PS1 transgenic mice...
February 12, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28191736/the-phosphoinositide-3-kinase-signaling-is-involved-in-neuroinflammation-in-hypertensive-rats
#3
Xing Tan, Pei-Lei Jiao, Yang-Kai Wang, Zhao-Tang Wu, Xiao-Rong Zeng, Miao-Ling Li, Wei-Zhong Wang
AIMS: It has been demonstrated that neuroinflammation is associated with cardiovascular dysfunction. The phosphoinositide-3 kinase (PI3K) signaling in the rostral ventrolateral medulla (RVLM), a key region for sympathetic outflow, is upregulated and contributes to increased blood pressure (BP) and sympathetic outflow in hypertension. This study was designed to determine the role of the PI3K signaling in neuroinflammation in the RVLM of hypertension. METHODS: The normotensive WKY rats were performed by intracisternal infusion of lipopolysaccharide (LPS) or angiotensin II (Ang II) for inducing neuroinflammation...
February 12, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28168849/cpne5-is-involved-in-regulating-rodent-anxiety-level
#4
LETTER
Xue-Feng Ding, He-Jun Wang, Lu Qian, Zeng-Yao Hu, Shu-Fang Feng, Yan Wu, Hai-Hong Yang, Hai-Tao Wu, Wen-Hong Fan, Ming Fan
No abstract text is available yet for this article.
February 6, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28168839/histamine-h3-receptor-antagonist-prevents-memory-deficits-and-synaptic-plasticity-disruption-following-isoflurane-exposure
#5
Tao Luo, Ying Wang, Jian Qin, Zhi-Gang Liu, Min Liu
BACKGROUND: Exposure to pharmacological concentration of inhaled anesthetics such as isoflurane can cause short- or long-term cognitive impairments in preclinical studies. The selective antagonists of the histamine H3 receptors are considered as a promising group of novel therapeutic agents for the treatment of cognitive disorders. In this study, we investigated whether ciproxifan, a nonimidazole antagonist of H3 histamine receptors, could overcome the functional and electrophysiological sequela associated with isoflurane anesthesia...
February 6, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28130864/complex-roles-of-annexin-a2-in-host-blood-brain-barrier-invasion-by-cryptococcus-neoformans
#6
Wei Fang, Zhen-Zong Fa, Qun Xie, Gui-Zhen Wang, Jiu Yi, Chao Zhang, Guang-Xun Meng, Ju-Lin Gu, Wan-Qing Liao
INTRODUCTION: Fungal transversal across the brain microvascular endothelial cells (BMECs) is the essential step for the development of cryptococcal meningoencephalitis. Annexin A2 (AnxA2) is an important signaling protein involved in several intracellular processes such as membrane trafficking, endocytosis, and exocytosis. AIM: To investigate the roles and mechanism of AnxA2 during cryptococcal transversal of BMECs. RESULTS: Cryptococcus neoformans infection initiated upregulation of AnxA2 in mouse BMECs...
January 28, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28098430/behavioral-and-electrophysiological-alterations-for-reinforcement-learning-in-manic-and-euthymic-patients-with-bipolar-disorder
#7
Vin Ryu, Ra Yeon Ha, Su Jin Lee, Kyooseob Ha, Hyun-Sang Cho
AIMS: Bipolar disorder is characterized by behavioral changes such as risk-taking and increasing goal-directed activities, which may result from altered reward processing. Patients with bipolar disorder show impaired reward learning in situations that require the integration of reinforced feedback over time. In this study, we examined the behavioral and electrophysiological characteristics of reward learning in manic and euthymic patients with bipolar disorder using a probabilistic reward task...
January 18, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28071873/cognitive-stress-reduces-the-effect-of-levodopa-on-parkinson-s-resting-tremor
#8
Heidemarie Zach, Michiel F Dirkx, Jaco W Pasman, Bastiaan R Bloem, Rick C Helmich
AIMS: Resting tremor in Parkinson's disease (PD) increases markedly during cognitive stress. Dopamine depletion in the basal ganglia is involved in the pathophysiology of resting tremor, but it is unclear whether this contribution is altered under cognitive stress. We test the hypothesis that cognitive stress modulates the levodopa effect on resting tremor. METHODS: Tremulous PD patients (n = 69) were measured in two treatment conditions (OFF vs. ON levodopa) and in two behavioral contexts (rest vs...
January 10, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28052569/effect-of-coenzyme-q10-on-psychopathological-symptoms-in-fibromyalgia-patients
#9
LETTER
Elísabet Alcocer-Gómez, Ognjen Culic, José M Navarro-Pando, José A Sánchez-Alcázar, Pedro Bullón
No abstract text is available yet for this article.
January 4, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28052528/the-change-of-nociceptive-neurons-in-the-rat-trigeminal-ganglia-at-different-postnatal-ages
#10
LETTER
Mei-Qi Zeng, Jun-Fei Niu, Ping Luan, Ying Ying, Rui-Ping Pang, Qing-Ning Su, Hua-Zhang Zhu, Jing-Qiang Huang, Hu-Ju Chi, Li-Hong Zhang, Xin-Min Fan, Ou Sha
No abstract text is available yet for this article.
January 4, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28044431/abnormal-resting-state-neural-activity-and-connectivity-of-fatigue-in-parkinson-s-disease
#11
Jie-Jin Zhang, Jian Ding, Jun-Yi Li, Min Wang, Yong-Sheng Yuan, Li Zhang, Si-Ming Jiang, Xi-Xi Wang, Lin Zhu, Ke-Zhong Zhang
AIMS: Fatigue is a common burdensome problem in patients with Parkinson's disease (PD), but its pathophysiological mechanisms are poorly understood. This study aimed at investigating the neural substrates of fatigue in patients with PD. METHODS: A total of 17 PD patients with fatigue, 32 PD patients without fatigue, and 25 matched healthy controls were recruited. The 9-item fatigue severity scale (FSS) was used for fatigue screening and severity rating. Resting-state functional magnetic resonance imaging (RS-fMRI) data were obtained from all subjects...
January 3, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28044424/ocular-nerve-growth-factor-administration-modulates-brain-derived-neurotrophic-factor-signaling-in-prefrontal-cortex-of-healthy-and-diabetic-rats
#12
Pamela Rosso, Sara De Nicolò, Valentina Carito, Marco Fiore, Angela Iannitelli, Sandra Moreno, Paola Tirassa
AIMS: Nerve growth factor (NGF) eyedrops (ed-NGF) activate brain neurons, stimulate growth factors, including brain-derived neurotrophic factor (BDNF), and exert neuroprotection in the forebrain of streptozotocin-induced diabetic rats (STZ rats). In this study, the effects of ed-NGF on BDNF signaling in the prefrontal cortex (PFC) were explored in healthy and STZ-diabetic rats, in which cortical neuronal and axonal loss, and altered circulating BDNF associated with depressive phenotype are also described...
January 3, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27996211/gsk-3%C3%AE-interacts-with-dopamine-d1-receptor-to-regulate-receptor-function-implication-for-prefrontal-cortical-d1-receptor-dysfunction-in-schizophrenia
#13
Jing-Ru Wang, Pei-Hua Sun, Zhao-Xiang Ren, Herbert Y Meltzer, Xue-Chu Zhen
INTRODUCTION: Impaired dopamine D1 receptor (D1R) function in prefrontal cortex (PFC) is believed to contribute to the PFC hypofunction that has been hypothesized to be associated with negative symptoms and cognitive deficits in schizophrenia. It is therefore critical to understand the mechanisms for modulation of D1R function. AIMS: To investigate the physical interaction and functional modulation between D1R and GSK-3β. RESULTS: D1R and GSK-3β physically interact in cultured cells and native brain tissues...
December 20, 2016: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27991729/inhibiting-the-migration-of-m1-microglia-at-hyperacute-period-could-improve-outcome-of-tmcao-rats
#14
Ming Huang, Yan Wan, Ling Mao, Quan-Wei He, Yuan-Peng Xia, Man Li, Ya-Nan Li, Hui-Juan Jin, Bo Hu
AIM: To study whether inhibiting microglia migration to the ischemic boundary zone (IBZ) at the early phase could improve neurological outcomes after stroke. METHODS: The transient middle cerebral artery occlusion (tMCAO) was induced in adult male Sprague-Dawley rats. AMD3100, a highly selective CXC-chemokine receptor 4 (CXCR4) antagonist, was used to inhibit microglia migration. Microglia was evaluated by immunofluorescence in vivo, and their migration was tested by transwell assay in vitro...
December 19, 2016: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27976523/neonatal-maternal-deprivation-enhances-presynaptic-p2x7-receptor-transmission-in-insular-cortex-in-an-adult-rat-model-of-visceral-hypersensitivity
#15
Ping-An Zhang, Qiya Xu, Lu Xue, Hang Zheng, Jun Yan, Ying Xiao, Guang-Yin Xu
AIMS: Insular cortex (IC) is involved in processing the information of pain. The aim of this study was to investigate roles and mechanisms of P2X7 receptors (P2X7Rs) in IC in development of visceral hypersensitivity of adult rats with neonatal maternal deprivation (NMD). METHODS: Visceral hypersensitivity was quantified by abdominal withdrawal reflex threshold to colorectal distension (CRD). Expression of P2X7Rs was determined by qPCR and Western blot. Synaptic transmission in IC was recorded by patch-clamp recording...
December 15, 2016: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28198167/signal-peptide-peptidase-encoded-by-hm13-contributes-to-tumor-progression-by-affecting-egfrviii-secretion-profiles-in-glioblastoma
#16
Jian-Wei Wei, Jin-Quan Cai, Chuan Fang, Yan-Li Tan, Kai Huang, Chao Yang, Qun Chen, Chuan-Lu Jiang, Chun-Sheng Kang
BACKGROUND AND AIMS: EGFRvIII is the most prevalent glioblastoma mutation, occurring in more than 25% of glioblastomas. EGFRvIII cells release microvesicles that contain proteins, miRNAs, and mRNAs that enhance the growth and survival of surrounding tumor cells. However, little is known about the maturation process and regulatory mechanisms of secreted vesicles in EGFRvIII cells. METHODS: Signal peptide peptidase (SPP) provides a fascinating mechanism for protein cleavage and subsequent dislocation in the endoplasmic reticulum transmembrane domain...
March 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28145081/chronic-sleep-restriction-induces-cognitive-deficits-and-cortical-beta-amyloid-deposition-in-mice-via-bace1-antisense-activation
#17
Hong-Yi Zhao, Hui-Juan Wu, Jia-Lin He, Jian-Hua Zhuang, Zhen-Yu Liu, Liu-Qing Huang, Zhong-Xin Zhao
AIMS: To clarify the correlation between chronic sleep restriction (CSR) and sporadic Alzheimer disease (AD), we determined in wild-type mice the impact of CSR, on cognitive performance, beta-amyloid (Aβ) peptides, and its feed-forward regulators regarding AD pathogenesis. METHODS: Sixteen nine-month-old C57BL/6 male mice were equally divided into the CSR and control groups. CSR was achieved by application of a slowly rotating drum for 2 months. The Morris water maze test was used to assess cognitive impairment...
March 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27917616/effect-of-redox-modifying-agents-on-the-activity-of-channelrhodopsin-2
#18
Bao-Ming Wu, Tian-Dong Leng, Koichi Inoue, Jun Li, Zhi-Gang Xiong
BACKGROUND: The algal protein Channelrhodopsin-2 (ChR2) has been widely used in recent years in optogenetic technique to investigate the functions of complex neuronal networks through minimally invasive and temporally precise photostimulation of genetically defined neurons. However, as with any other new technique, current optogentic approaches have various limitations. In addition, how ChR2 may behave in response to complex biochemical changes associated with various physiological/pathological conditions is largely unknown...
March 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27943591/effects-of-lrrk2-inhibitors-on-nigrostriatal-dopaminergic-neurotransmission
#19
Qi Qin, Lian-Teng Zhi, Xian-Ting Li, Zhen-Yu Yue, Guo-Zhong Li, Hui Zhang
INTRODUCTION: Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most prevalent cause of familial and sporadic Parkinson's disease (PD). Because most pathogenic LRRK2 mutations result in enhanced kinase activity, it suggests that LRRK2 inhibitors may serve as a potential treatment for PD. To evaluate whether LRRK2 inhibitors are effective therapies for PD, it is crucial to know whether LRRK2 inhibitors will affect dopaminergic (DAergic) neurotransmission. However, to date, there is no study to investigate the impact of LRRK2 inhibitors on DAergic neurotransmission...
February 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27864869/anthoxanthin-polyphenols-attenuate-a%C3%AE-oligomer-induced-neuronal-responses-associated-with-alzheimer-s-disease
#20
Kayla M Pate, McCall Rogers, John Will Reed, Nicholas van der Munnik, Steven Zebulon Vance, Melissa A Moss
AIMS: Epidemiological evidence implicates polyphenols as potential natural therapeutics for Alzheimer's disease (AD). To investigate this prospect, five anthoxanthin polyphenols were characterized for their ability to reduce amyloid-β (Aβ) oligomer-induced neuronal responses by two mechanisms of action, modulation of oligomerization and antioxidant activity, as well as the synergy between these two mechanisms. METHODS: Anthoxanthin oligomerization modulation and antioxidant capabilities were evaluated and correlated with anthoxanthin attenuation of oligomer-induced intracellular reactive oxygen species (ROS) and caspase activation using human neuroblastoma cell treatments designed to isolate these mechanisms of action and to achieve dual-action...
February 2017: CNS Neuroscience & Therapeutics
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