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CNS Neuroscience & Therapeutics

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https://www.readbyqxmd.com/read/28098430/behavioral-and-electrophysiological-alterations-for-reinforcement-learning-in-manic-and-euthymic-patients-with-bipolar-disorder
#1
Vin Ryu, Ra Yeon Ha, Su Jin Lee, Kyooseob Ha, Hyun-Sang Cho
AIMS: Bipolar disorder is characterized by behavioral changes such as risk-taking and increasing goal-directed activities, which may result from altered reward processing. Patients with bipolar disorder show impaired reward learning in situations that require the integration of reinforced feedback over time. In this study, we examined the behavioral and electrophysiological characteristics of reward learning in manic and euthymic patients with bipolar disorder using a probabilistic reward task...
January 18, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28071873/cognitive-stress-reduces-the-effect-of-levodopa-on-parkinson-s-resting-tremor
#2
Heidemarie Zach, Michiel F Dirkx, Jaco W Pasman, Bastiaan R Bloem, Rick C Helmich
AIMS: Resting tremor in Parkinson's disease (PD) increases markedly during cognitive stress. Dopamine depletion in the basal ganglia is involved in the pathophysiology of resting tremor, but it is unclear whether this contribution is altered under cognitive stress. We test the hypothesis that cognitive stress modulates the levodopa effect on resting tremor. METHODS: Tremulous PD patients (n = 69) were measured in two treatment conditions (OFF vs. ON levodopa) and in two behavioral contexts (rest vs...
January 10, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28052569/effect-of-coenzyme-q10-on-psychopathological-symptoms-in-fibromyalgia-patients
#3
LETTER
Elísabet Alcocer-Gómez, Ognjen Culic, José M Navarro-Pando, José A Sánchez-Alcázar, Pedro Bullón
No abstract text is available yet for this article.
January 4, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28052528/the-change-of-nociceptive-neurons-in-the-rat-trigeminal-ganglia-at-different-postnatal-ages
#4
LETTER
Mei-Qi Zeng, Jun-Fei Niu, Ping Luan, Ying Ying, Rui-Ping Pang, Qing-Ning Su, Hua-Zhang Zhu, Jing-Qiang Huang, Hu-Ju Chi, Li-Hong Zhang, Xin-Min Fan, Ou Sha
No abstract text is available yet for this article.
January 4, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28044431/abnormal-resting-state-neural-activity-and-connectivity-of-fatigue-in-parkinson-s-disease
#5
Jie-Jin Zhang, Jian Ding, Jun-Yi Li, Min Wang, Yong-Sheng Yuan, Li Zhang, Si-Ming Jiang, Xi-Xi Wang, Lin Zhu, Ke-Zhong Zhang
AIMS: Fatigue is a common burdensome problem in patients with Parkinson's disease (PD), but its pathophysiological mechanisms are poorly understood. This study aimed at investigating the neural substrates of fatigue in patients with PD. METHODS: A total of 17 PD patients with fatigue, 32 PD patients without fatigue, and 25 matched healthy controls were recruited. The 9-item fatigue severity scale (FSS) was used for fatigue screening and severity rating. Resting-state functional magnetic resonance imaging (RS-fMRI) data were obtained from all subjects...
January 3, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28044424/ocular-nerve-growth-factor-administration-modulates-brain-derived-neurotrophic-factor-signaling-in-prefrontal-cortex-of-healthy-and-diabetic-rats
#6
Pamela Rosso, Sara De Nicolò, Valentina Carito, Marco Fiore, Angela Iannitelli, Sandra Moreno, Paola Tirassa
AIMS: Nerve growth factor (NGF) eyedrops (ed-NGF) activate brain neurons, stimulate growth factors, including brain-derived neurotrophic factor (BDNF), and exert neuroprotection in the forebrain of streptozotocin-induced diabetic rats (STZ rats). In this study, the effects of ed-NGF on BDNF signaling in the prefrontal cortex (PFC) were explored in healthy and STZ-diabetic rats, in which cortical neuronal and axonal loss, and altered circulating BDNF associated with depressive phenotype are also described...
January 3, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27996211/gsk-3%C3%AE-interacts-with-dopamine-d1-receptor-to-regulate-receptor-function-implication-for-prefrontal-cortical-d1-receptor-dysfunction-in-schizophrenia
#7
Jing-Ru Wang, Pei-Hua Sun, Zhao-Xiang Ren, Herbert Y Meltzer, Xue-Chu Zhen
INTRODUCTION: Impaired dopamine D1 receptor (D1R) function in prefrontal cortex (PFC) is believed to contribute to the PFC hypofunction that has been hypothesized to be associated with negative symptoms and cognitive deficits in schizophrenia. It is therefore critical to understand the mechanisms for modulation of D1R function. AIMS: To investigate the physical interaction and functional modulation between D1R and GSK-3β. RESULTS: D1R and GSK-3β physically interact in cultured cells and native brain tissues...
December 20, 2016: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27991729/inhibiting-the-migration-of-m1-microglia-at-hyperacute-period-could-improve-outcome-of-tmcao-rats
#8
Ming Huang, Yan Wan, Ling Mao, Quan-Wei He, Yuan-Peng Xia, Man Li, Ya-Nan Li, Hui-Juan Jin, Bo Hu
AIM: To study whether inhibiting microglia migration to the ischemic boundary zone (IBZ) at the early phase could improve neurological outcomes after stroke. METHODS: The transient middle cerebral artery occlusion (tMCAO) was induced in adult male Sprague-Dawley rats. AMD3100, a highly selective CXC-chemokine receptor 4 (CXCR4) antagonist, was used to inhibit microglia migration. Microglia was evaluated by immunofluorescence in vivo, and their migration was tested by transwell assay in vitro...
December 19, 2016: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27976523/neonatal-maternal-deprivation-enhances-presynaptic-p2x7-receptor-transmission-in-insular-cortex-in-an-adult-rat-model-of-visceral-hypersensitivity
#9
Ping-An Zhang, Qiya Xu, Lu Xue, Hang Zheng, Jun Yan, Ying Xiao, Guang-Yin Xu
AIMS: Insular cortex (IC) is involved in processing the information of pain. The aim of this study was to investigate roles and mechanisms of P2X7 receptors (P2X7Rs) in IC in development of visceral hypersensitivity of adult rats with neonatal maternal deprivation (NMD). METHODS: Visceral hypersensitivity was quantified by abdominal withdrawal reflex threshold to colorectal distension (CRD). Expression of P2X7Rs was determined by qPCR and Western blot. Synaptic transmission in IC was recorded by patch-clamp recording...
December 15, 2016: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27943591/effects-of-lrrk2-inhibitors-on-nigrostriatal-dopaminergic-neurotransmission
#10
Qi Qin, Lian-Teng Zhi, Xian-Ting Li, Zhen-Yu Yue, Guo-Zhong Li, Hui Zhang
INTRODUCTION: Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most prevalent cause of familial and sporadic Parkinson's disease (PD). Because most pathogenic LRRK2 mutations result in enhanced kinase activity, it suggests that LRRK2 inhibitors may serve as a potential treatment for PD. To evaluate whether LRRK2 inhibitors are effective therapies for PD, it is crucial to know whether LRRK2 inhibitors will affect dopaminergic (DAergic) neurotransmission. However, to date, there is no study to investigate the impact of LRRK2 inhibitors on DAergic neurotransmission...
December 9, 2016: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27917616/effect-of-redox-modifying-agents-on-the-activity-of-channelrhodopsin-2
#11
Bao-Ming Wu, Tian-Dong Leng, Koichi Inoue, Jun Li, Zhi-Gang Xiong
BACKGROUND: The algal protein Channelrhodopsin-2 (ChR2) has been widely used in recent years in optogenetic technique to investigate the functions of complex neuronal networks through minimally invasive and temporally precise photostimulation of genetically defined neurons. However, as with any other new technique, current optogentic approaches have various limitations. In addition, how ChR2 may behave in response to complex biochemical changes associated with various physiological/pathological conditions is largely unknown...
December 4, 2016: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27860375/differential-impairment-of-thalamocortical-structural-connectivity-in-amyotrophic-lateral-sclerosis
#12
Jiu-Quan Zhang, Bing Ji, Chao-Yang Zhou, Long-Chuan Li, Zhi-Hao Li, Xiao-Ping Hu, Jun Hu
AIMS: The thalamus is a major relay station that modulates input from many cortical areas and a filter for sensory input and is involved in the pathophysiology of amyotrophic lateral sclerosis (ALS). However, it still remains unclear whether all thalamocortical networks are affected or whether there is selective vulnerability. In this study, we aimed to study the selective vulnerability of different thalamocortical structural connections in ALS and to test the hypothesis of a specific impairment in motor-related thalamocortical connectivity...
November 12, 2016: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27864869/anthoxanthin-polyphenols-attenuate-a%C3%AE-oligomer-induced-neuronal-responses-associated-with-alzheimer-s-disease
#13
Kayla M Pate, McCall Rogers, John Will Reed, Nicholas van der Munnik, Steven Zebulon Vance, Melissa A Moss
AIMS: Epidemiological evidence implicates polyphenols as potential natural therapeutics for Alzheimer's disease (AD). To investigate this prospect, five anthoxanthin polyphenols were characterized for their ability to reduce amyloid-β (Aβ) oligomer-induced neuronal responses by two mechanisms of action, modulation of oligomerization and antioxidant activity, as well as the synergy between these two mechanisms. METHODS: Anthoxanthin oligomerization modulation and antioxidant capabilities were evaluated and correlated with anthoxanthin attenuation of oligomer-induced intracellular reactive oxygen species (ROS) and caspase activation using human neuroblastoma cell treatments designed to isolate these mechanisms of action and to achieve dual-action...
February 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27873462/mitochondrial-dysfunction-and-biogenesis-in-neurodegenerative-diseases-pathogenesis-and-treatment
#14
REVIEW
Mojtaba Golpich, Elham Amini, Zahurin Mohamed, Raymond Azman Ali, Norlinah Mohamed Ibrahim, Abolhassan Ahmadiani
Neurodegenerative diseases are a heterogeneous group of disorders that are incurable and characterized by the progressive degeneration of the function and structure of the central nervous system (CNS) for reasons that are not yet understood. Neurodegeneration is the umbrella term for the progressive death of nerve cells and loss of brain tissue. Because of their high energy requirements, neurons are especially vulnerable to injury and death from dysfunctional mitochondria. Widespread damage to mitochondria causes cells to die because they can no longer produce enough energy...
January 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27701827/beneficial-effects-of-co-ultramicronized-palmitoylethanolamide-luteolin-in-a-mouse-model-of-autism-and-in-a-case-report-of-autism
#15
Bartolomeo Bertolino, Rosalia Crupi, Daniela Impellizzeri, Giuseppe Bruschetta, Marika Cordaro, Rosalba Siracusa, Emanuela Esposito, Salvatore Cuzzocrea
AIMS: Autism spectrum disorder (ASD) is a condition defined by social communication deficits and repetitive restrictive behaviors. Association of the fatty acid amide palmitoylethanolamide (PEA) with the flavonoid luteolin displays neuroprotective and antiinflammatory actions in different models of central nervous system pathologies. We hypothesized that association of PEA with luteolin might have therapeutic utility in ASD, and we employed a well-recognized autism animal model, namely sodium valproate administration, to evaluate cognitive and motor deficits...
January 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27671373/impaired-spatial-learning-is-associated-with-disrupted-integrity-of-the-white-matter-in-akt3-knockout-mice
#16
LETTER
He Wang, Bao-Feng Zhang, Ting-Ting Zhang, Long Wang, Xiao-Yan Zou, Yun Xu, Ling Chen, Gui-Quan Chen
No abstract text is available yet for this article.
January 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27663605/levodopa-effect-on-basal-ganglia-motor-circuit-in-parkinson-s-disease
#17
Lin-Lin Gao, Jia-Rong Zhang, Piu Chan, Tao Wu
AIMS: To investigate the effects of levodopa on the basal ganglia motor circuit (BGMC) in Parkinson's disease (PD). METHODS: Thirty PD patients with asymmetrical bradykinesia and 30 control subjects were scanned using resting-state functional MRI. Functional connectivity of the BGMC was measured and compared before and after levodopa administration in patients with PD. The correlation between improvements in bradykinesia and changes in BGMC connectivity was examined...
January 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27637748/overexpression-of-paxillin-correlates-with-tumor-progression-and-predicts-poor-survival-in-glioblastoma
#18
Li-Hua Sun, Fu-Qiang Yang, Chuan-Bao Zhang, Yi-Ping Wu, Jing-Shan Liang, Shuai Jin, Zheng Wang, Hong-Jun Wang, Zhao-Shi Bao, Zheng-Xiang Yang, Tao Jiang
AIMS: To explore the prognostic and clinicopathological features of glioma with Paxillin (PXN) expression based on a large number of samples. METHODS: RNA sequencing data of 325 glioma samples from Chinese Glioma Genome Atlas (CGGA) database were obtained as discovery set. Three additional datasets were further obtained as validation sets. The protein expression pattern of PXN in glioma was measured by IHC. Kaplan-Meier survival and multivariate Cox analysis were used to estimate the survival distributions...
January 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27534449/upregulations-of-crh-and-crhr1-in-the-epileptogenic-tissues-of-patients-with-intractable-infantile-spasms
#19
Xiao-Lin Yang, Bing Chen, Xiao-Qing Zhang, Xin Chen, Mei-Hua Yang, Wei Zhang, Huan-Ran Chen, Zhen-Le Zang, Wei Li, Hui Yang, Shi-Yong Liu
AIM: Infantile spasms (IS) are an age-specific epileptic syndrome with specific clinical symptom and electroencephalogram (EEG) features, lacking treatment options, and a poor prognosis. Excessive endogenous corticotropin-releasing hormone (CRH) in infant brain might result in IS. However, the data from human IS are limited. In our study, we investigated the expressions of CRH and its receptor type 1 (CRHR1) in surgical tissues from patients with IS and autopsy controls. METHODS: Specimens surgically removed from 17 patients with IS, and six autopsy controls were included in the study...
January 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27424519/the-potential-of-indole-indolylquinoline-compounds-in-tau-misfolding-reduction-by-enhancement-of-hspb1
#20
Kuo-Hsuan Chang, Chih-Hsin Lin, Hsuan-Chiang Chen, Hsin-Yu Huang, Shu-Ling Chen, Te-Hsien Lin, Chintakunta Ramesh, Chin-Chang Huang, Hon-Chung Fung, Yih-Ru Wu, Hei-Jen Huang, Guey-Jen Lee-Chen, Hsiu Mei Hsieh-Li, Ching-Fa Yao
BACKGROUND: Neurofibrillary tangles formed from tau misfolding have long been considered one of the pathological hallmarks of Alzheimer's disease (AD). The misfolding of tau in AD correlates with the clinical progression of AD and inhibition or reversal of tau misfolding may protect the affected neurons. METHODS: We generated 293 and SH-SY5Y cells expressing DsRed-tagged pro-aggregation mutant of repeat domain of tau (ΔK280 tauRD ) to test indole/indolylquinoline derivatives for reducing tau misfolding and neuroprotection...
January 2017: CNS Neuroscience & Therapeutics
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