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CNS Neuroscience & Therapeutics

Andrei Miclea, Anke Salmen, Greta Zoehner, Lara Diem, Christian P Kamm, Panos Chaloulos-Iakovidis, Marius Miclea, Myriam Briner, Kostas Kilidireas, Leonidas Stefanis, Andrew Chan, Maria Eleftheria Evangelopoulos, Robert Hoepner
INTRODUCTION: Multiple sclerosis (MS) is an autoimmune disease of the CNS, which predominantly affects women. Studies investigating the sex distribution in MS are sparse. We aim to analyze the female-to-male ratio (F/M ratio) in different MS phenotypes in association with age at diagnosis and year of birth. METHODS: We performed a retrospective cross-sectional analysis by cumulating data (sex, year of birth, age at diagnosis, and MS phenotypes) from unpublished and published studies of the participating centers...
November 8, 2018: CNS Neuroscience & Therapeutics
Francesco Angelucci, Kateřina Čechová, Richard Průša, Jakub Hort
Soluble oligomeric forms of amyloid beta (Aβ) play an important role in causing the cognitive deficits in Alzheimer's disease (AD) by targeting and disrupting synaptic pathways. Thus, the present research is directed toward identifying the neuronal pathways targeted by soluble forms and, accordingly, develops alternative therapeutic strategies. The neurotrophin brain-derived neurotrophic factor (BDNF) is synthesized as a precursor (pro-BDNF) which is cleaved extracellularly by plasmin to release the mature form...
November 6, 2018: CNS Neuroscience & Therapeutics
Yan Li, Zi-Yu Zhu, Ting-Ting Huang, Yu-Xi Zhou, Xin Wang, Li-Qun Yang, Zeng-Ai Chen, Wei-Feng Yu, Pei-Ying Li
The blood-brain barrier (BBB) is a highly regulated interface that separates the peripheral circulation and the brain. It plays a vital role in regulating the trafficking of solutes, fluid, and cells at the blood-brain interface and maintaining the homeostasis of brain microenvironment for normal neuronal activity. Growing evidence has led to the realization that ischemic stroke elicits profound immune responses in the circulation and the activation of multiple subsets of immune cells, which in turn affect both the early disruption and the later repair of the BBB after stroke...
November 1, 2018: CNS Neuroscience & Therapeutics
Xin Wang, Wei Xuan, Zi-Yu Zhu, Yan Li, Hao Zhu, Ling Zhu, Dan-Yun Fu, Li-Qun Yang, Pei-Ying Li, Wei-Feng Yu
Stroke is the world's leading cause of disability with limited brain repair treatments which effectively improve long-term neurological deficits. The neuroinflammatory responses persist into the late repair phase of stroke and participate in all brain repair elements, including neurogenesis, angiogenesis, synaptogenesis, remyelination and axonal sprouting, shedding new light on post-stroke brain recovery. Resident brain glial cells, such as astrocytes not only contribute to neuroinflammation after stroke, but also secrete a wide range of trophic factors that can promote post-stroke brain repair...
October 22, 2018: CNS Neuroscience & Therapeutics
Xiao-Ting Zhang, Chun-Juan Wang, Bao-Jie Wang, Shou-Gang Guo
No abstract text is available yet for this article.
October 21, 2018: CNS Neuroscience & Therapeutics
Yun-Long Shen, He-Zhen Li, Yan-Wei Hu, Lei Zheng, Qian Wang
AIMS: In this study, we examined the expression of GINS2 in glioma and determined its role in glioma development. METHODS: The protein expression of GINS2 was assessed in 120 human glioma samples via immunohistochemistry. Then, we suppressed the expression of GINS2 in glioma cell strains U87 and U251 using a short hairpin RNA lentiviral vector. In addition, RNA sequencing and bioinformatics analysis were performed on glioma cells before and after GINS2 knockdown...
October 18, 2018: CNS Neuroscience & Therapeutics
Huan Wang, Yi-Xuan Yin, Dong-Mei Gong, Ling-Juan Hong, Gang Wu, Quan Jiang, Cheng-Kun Wang, Pablo Blinder, Sen Long, Feng Han, Ying-Mei Lu
AIMS: Autism spectrum disorder (ASD) is a wide range of neurodevelopmental disorders involving deficits in social interaction and communication. Unfortunately, autism remains a scientific and clinical challenge owing to the lack of understanding the cellular and molecular mechanisms underlying it. This study aimed to investigate the pathophysiological mechanism underlying leukocyte-endothelial adhesion in autism-related neurovascular inflammation. METHODS: Male BTBR T+tf/J mice were used as an autism model...
October 16, 2018: CNS Neuroscience & Therapeutics
Hae Won Kim, Jee In Kang, Suk Kyoon An, Se Joo Kim
AIMS: A growing body of literature has indicated that oxytocin is associated with several domains of social cognition and behavior. Nevertheless, the effects of oxytocin receptor gene (OXTR) polymorphisms on social phenotypes remain unclear. Therefore, we aimed to explore the genetic influence of OXTR variants on social cognition (social perception and theory of mind) and resilience in healthy individuals. METHODS: We examined the influence of 10 common OXTR variants on social cognitive abilities, including facial emotion recognition and theory of mind, and trait resilience in 264 unrelated, healthy participants...
October 11, 2018: CNS Neuroscience & Therapeutics
Ana María Estrada-Sánchez, Daniel Castro, Kenia Portillo-Ortiz, Katrina Jang, Michael Nedjat-Haiem, Michael S Levine, Carlos Cepeda
AIM: Deficient glutamate reuptake occurs in the cerebral cortex of Huntington's disease (HD) patients and murine models. Here, we examine the effects of partial or complete blockade of glutamate transporters on excitatory postsynaptic currents (EPSCs) of cortical pyramidal neurons (CPNs). METHODS: Whole-cell patch clamp recordings of CPNs in slices from symptomatic R6/2 mice and wild-type (WT) littermates were used to examine the effects of selective or concurrent inhibition of glutamate reuptake transporters...
October 11, 2018: CNS Neuroscience & Therapeutics
Qing Guo, Ge-Fei Guan, Wen Cheng, Cun-Yi Zou, Chen Zhu, Peng Cheng, An-Hua Wu
AIMS: Glioblastoma (GBM) is a lethal disease of the central nervous system with high mortality, and novel therapeutic targets and strategies for GBM are urgently needed. Caveolae-associated protein 1 (CAVIN1) is an essential caveolar component-encoding gene and has been poorly studied in glioma. To this end, in this study, we evaluated CAVIN1 expression in glioma tissue as well as the correlation between CAVIN1 expression and prognosis in glioma patients using the data collected from clinical samples or from the Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA), Rembrandt, and Gene Expression Omnibus (GEO) data sets...
October 11, 2018: CNS Neuroscience & Therapeutics
Kai-Liang Wang, Wei Hu, Ting-Hong Liu, Xiao-Bin Zhao, Chun-Lei Han, Xiao-Tong Xia, Jian-Guo Zhang, Feng Wang, Fan-Gang Meng
OBJECTIVE: We aimed to study the networks' mechanism of metabolic covariance networks in mesial temporal lobe epilepsy (mTLE), through examining the brain value of fluorine-18-fluorodeoxyglucose positron emission tomography (18 F-FDG-PET). METHODS: 18 F-FDG-PET images from 16 patients with mTLE were analyzed using local and global metabolic covariance network (MCN) approaches, including whole metabolic pattern analysis (WMPA), hippocampus-based (h-) MCN, whole brain (w-) MCN, and edge-based connectivity analysis (EBCA)...
October 8, 2018: CNS Neuroscience & Therapeutics
Guang-Zhi Ning, Wen-Ye Song, Hong Xu, Ru-Sen Zhu, Qiu-Li Wu, Yu Wu, Shi-Bo Zhu, Ji-Qing Li, Man Wang, Zhi-Gang Qu, Shi-Qing Feng
Stem cell transplantation, especially treatment with bone marrow mesenchymal stem cells (BMSCs), has been considered a promising therapy for the locomotor and neurological recovery of spinal cord injury (SCI) patients. However, the clinical benefits of BMSCs transplantation remain limited because of the considerably low viability and inhibitory microenvironment. In our research, low-intensity pulsed ultrasound (LIPUS), which has been widely applied to clinical applications and fundamental research, was employed to improve the properties of BMSCs...
October 8, 2018: CNS Neuroscience & Therapeutics
Davide Vito Moretti
AIMS: Success in treating patients with atypical parkinsonian syndromes, namely progressive supranuclear palsy (PSP), cortico-basal degeneration (CBD), multiple system atrophy (MSA), Parkinson's disease with dementia (PDD), and Lewy body dementia with (LBD), remains exceedingly low. The present work overviews the most influential research literature collected on MEDLINE, ISI Web of Science, Cochrane Library, and Scopus for available treatment in atypical parkinsonisms without time restriction...
October 7, 2018: CNS Neuroscience & Therapeutics
Li Ding, Wen-Hao Nan, Xian-Bing Zhu, Xiao-Ming Li, Li-Yan Zhou, Hou-Jie Chen, Lu Yu, Fahim Ullah Khan, Han-Bing Zhong, Xiao-Jun Shi
Autophagy is an essential cellular process concern with cellular homeostasis down-regulated by mTOR, whose activity can be modulated by rapamycin, a kind of lipophilic macrolide antibiotic, through forming a complex with immunophilin FKBP12 essential for mTOR regulation to induce autophagy. Therefore, rapamycin is normally used as a neuron protective agent. The immunophilin FKBP12 binding ligand FK506 is well known as an immunosuppressive agent by inhibiting the calcineurin expression. In this study, we synthesized a series of modified compounds based on the FKBP12 binding moiety to as same as the binding structure of rapamycin and FK506 particularly...
October 7, 2018: CNS Neuroscience & Therapeutics
Jing-Wen Yang, Xue-Rui Wang, Meng Zhang, Ling-Yong Xiao, Wen Zhu, Cai-Shuo Ji, Cun-Zhi Liu
AIMS: Acupuncture has been reported to affect vascular dementia through a variety of molecular mechanisms. An isobaric tag for relative and absolute quantification (iTRAQ) with high-resolution liquid chromatography-tandem mass spectrometry (LC-MS/MS) analyses makes it possible to attain a global profile of proteins. Hence, we used an iTRAQ-LC-MS/MS strategy to unravel the underlying mechanism of acupuncture. METHODS: Wistar rats were subjected to vascular dementia with bilateral common carotid occlusion...
October 2, 2018: CNS Neuroscience & Therapeutics
Bao-Shu Xie, Yi-Qin Wang, Yong Lin, Qing Mao, Jun-Feng Feng, Guo-Yi Gao, Ji-Yao Jiang
AIMS: Ferroptosis, a new form of iron-dependent programmed cell death, has been shown to be involved in a range of diseases. However, the role of ferroptosis in traumatic brain injury (TBI) has yet to be elucidated. We aimed to investigate whether ferroptosis is induced after TBI and whether the inhibition of ferroptosis would protect against traumatic brain injury in a controlled cortical impact injury (CCI) mouse model. METHODS: After establishing the TBI model in mice, we determined the biochemical and morphological changes associated with ferroptosis, including iron accumulation with Perl's staining, neuronal cell death with Fluoro-Jade B (FJB) staining, iron metabolism dysfunction with Western blotting, reactive oxygen species (ROS) accumulation with malondialdehyde (MDA) assays, and shrunken mitochondria with transmission electron microscopy...
September 28, 2018: CNS Neuroscience & Therapeutics
Jia-Ling Sheng, Yan Yan, Xiang-Hong Yang, Ti-Fei Yuan, Dong-Hong Cui
No abstract text is available yet for this article.
September 28, 2018: CNS Neuroscience & Therapeutics
Ji-Qiang Fu, Zhen Chen, Yong-Jia Hu, Zhao-Huan Fan, Zhen-Xing Guo, Jin-Ye Liang, Bo-Mi Ryu, Jian-Lin Ren, Xiu-Juan Shi, Jiao Li, Song Jia, Juan Wang, Xiao-Si Ke, Xin Ma, Xiao Tan, Ting Zhang, Xian-Zhen Chen, Chen Zhang
AIM: Glioma, with fast growth and progression features, is the most common and aggressive tumor in the central nervous system and is essentially incurable. This study is aimed at inducing neuronal differentiation to suppress glioma cell growth with a single transcription factor. METHODS: Overexpression of transcription factor SRY (sex determining region Y)-box 11 (SOX11) and Zic family member 1 (ZIC1) was, respectively, performed in glioma cells with lentivirus infection...
September 27, 2018: CNS Neuroscience & Therapeutics
Eva Koetsier, Glenn Franken, Jacques Debets, Sander M J van Kuijk, Roberto S G M Perez, Bengt Linderoth, Elbert A J Joosten, Paolo Maino
AIMS: Conventional dorsal root ganglion stimulation (DRGS) is known to achieve better pain-paresthesia overlap of difficult-to-reach areas like the feet compared to dorsal column spinal cord stimulation (SCS). As in painful diabetic polyneuropathy (PDPN) pain is mostly present in the feet, we hypothesized that DRGS is more effective in relieving pain in PDPN when compared to SCS. METHODS: Diabetes was induced in female Sprague-Dawley rats with an intraperitoneal injection of 65 mg/kg of streptozotocin (STZ; n = 48)...
September 23, 2018: CNS Neuroscience & Therapeutics
Isabelle Niespodziany, Brice Mullier, Véronique Marie André, Philippe Ghisdal, Eric Jnoff, David Moreno-Delgado, Dominique Swinnen, Zara Sands, Martyn Wood, Christian Wolff
AIMS: Kv1.1 (KCNA1) channels contribute to the control of neuronal excitability and have been associated with epilepsy. Kv1.1 channels can associate with the cytoplasmic Kvβ1 subunit resulting in rapid inactivating A-type currents. We hypothesized that removal of channel inactivation, by modulating Kv1.1/Kvβ1 interaction with a small molecule, would lead to decreased neuronal excitability and anticonvulsant activity. METHODS: We applied high-throughput screening to identify ligands able to modulate the Kv1...
September 21, 2018: CNS Neuroscience & Therapeutics
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