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CNS Neuroscience & Therapeutics

Simone A A Romariz, Daisyléa S Paiva, Layla T Galindo, Gabriela F Barnabé, Vivian A Guedes, Cesario V Borlongan, Beatriz M Longo
AIMS: Medial ganglionic eminence (MGE) progenitors give rise to inhibitory interneurons and may serve as an alternative cell source for large-scale cell transplantation for epilepsy after in vitro expansion. We investigated whether modifications in the culture medium of MGE neurospheres affect neuronal differentiation and expression of MGE-specific genes. In vivo, we compared anticonvulsant effects and cell differentiation pattern among neurospheres grown in different culture media and compared them with freshly harvested MGE cells...
October 21, 2016: CNS Neuroscience & Therapeutics
Raquel Fonseca, Rui A Carvalho, Cristina Lemos, Ana C Sequeira, Inês R Pita, Fábio Carvalho, Carlos D Silva, Rui D S Prediger, Ivana Jarak, Rodrigo A Cunha, Carlos A Fontes Ribeiro, Attila Köfalvi, Frederico C Pereira
INTRODUCTION: We recently showed that a single high dose of methamphetamine (METH) induces a persistent frontal cortical monoamine depletion that is accompanied by helpless-like behavior in mice. However, brain metabolic alterations underlying both neurochemical and mood alterations remain unknown. AIMS: Herein, we aimed at characterizing frontal cortical metabolic alterations associated with early negative mood behavior triggered by METH. Adult C57BL/6 mice were injected with METH (30 mg/kg, i...
October 19, 2016: CNS Neuroscience & Therapeutics
Anat Levin, Anat Scher
INTRODUCTION: Disrupted sleep is common among children with autism spectrum disorder (ASD). AIMS: Our goal was to (1) examine the contribution of sleep problems to parenting stress in children with ASD as compared to typically developing (TD) and (2) to address maternal sleep-related cognitions and behaviors in both groups. METHODS: Mothers of 34 ASD (mean age = 39.29 months, SD = 5.22) and 31 TD children (mean age = 36.23 months, SD = 5.75) completed questionnaires measuring maternal stress, sleep-related cognitions and settling to sleep interactions, and the child's sleep problems; mothers in the ASD group completed a symptom severity questionnaire...
October 17, 2016: CNS Neuroscience & Therapeutics
Karen Spruyt, Wiebe Braam, Marcel Smits, Leopold Mg Curfs
AIMS: Individuals with Smith-Magenis syndrome (SMS) are reported to have a disrupted circadian rhythm. Our aim was to examine problematic sleeping in those attending our sleep clinic for the first time. METHODS: At intake, caregivers of 50 children and nine adults with SMS were surveyed about the sleep pattern and potential melatonin administration. Sampling of salivary melatonin levels was performed. RESULTS: At intake, exogenous melatonin was used by 16 children (27...
October 14, 2016: CNS Neuroscience & Therapeutics
Markus Kinner, Robert Hoepner, Peter Klotz, Christian Prehn, Simon Faissner, Anke Salmen, Ralf A Linker, Ralf Gold, Andrew Chan
No abstract text is available yet for this article.
October 13, 2016: CNS Neuroscience & Therapeutics
Bartolomeo Bertolino, Rosalia Crupi, Daniela Impellizzeri, Giuseppe Bruschetta, Marika Cordaro, Rosalba Siracusa, Emanuela Esposito, Salvatore Cuzzocrea
AIMS: Autism spectrum disorder (ASD) is a condition defined by social communication deficits and repetitive restrictive behaviors. Association of the fatty acid amide palmitoylethanolamide (PEA) with the flavonoid luteolin displays neuroprotective and antiinflammatory actions in different models of central nervous system pathologies. We hypothesized that association of PEA with luteolin might have therapeutic utility in ASD, and we employed a well-recognized autism animal model, namely sodium valproate administration, to evaluate cognitive and motor deficits...
October 4, 2016: CNS Neuroscience & Therapeutics
Ling-Lin Chen, Mei-Ling Wu, Feng Zhu, Jie-Jing Kai, Jing-Yin Dong, Xi-Mei Wu, Ling-Hui Zeng
AIMS: Previous study suggests that mTOR signaling pathway may play an important role in epileptogenesis. The present work was designed to explore the contribution of raptor protein to the development of epilepsy and comorbidities. METHODS: Mice with conditional knockout of raptor protein were generated by cross-bred Rptor(flox/flox) mice with nestin-CRE mice. The expression of raptor protein was analyzed by Western blotting in brain tissue samples. Neuronal death and mossy fiber sprouting were detected by FJB staining and Timm staining, respectively...
September 28, 2016: CNS Neuroscience & Therapeutics
He Wang, Bao-Feng Zhang, Ting-Ting Zhang, Long Wang, Xiao-Yan Zou, Yun Xu, Ling Chen, Gui-Quan Chen
No abstract text is available yet for this article.
September 27, 2016: CNS Neuroscience & Therapeutics
Da-Ming Cui, Tao Zeng, Jie Ren, Ke Wang, Yi Jin, Lin Zhou, Liang Gao
AIMS: Traumatic brain injury (TBI) is induced by complex primary and secondary mechanisms that give rise to cell death, inflammation, and neurological dysfunction. Understanding the mechanisms that drive neurological damage as well as those that promote repair can guide the development of therapeutic drugs for TBI. Kruppel-like factor 4 (KLF4) has been reported to negatively regulate axon regeneration of injured retinal ganglion cells (RGCs) through inhibition of JAK-STAT3 signaling. However, the role of KLF4 in TBI remains unreported...
September 27, 2016: CNS Neuroscience & Therapeutics
Lin-Lin Gao, Jiarong Zhang, Piu Chan, Tao Wu
AIMS: To investigate the effects of levodopa on the basal ganglia motor circuit (BGMC) in Parkinson's disease (PD). METHODS: Thirty PD patients with asymmetrical bradykinesia and 30 control subjects were scanned using resting-state functional MRI. Functional connectivity of the BGMC was measured and compared before and after levodopa administration in patients with PD. The correlation between improvements in bradykinesia and changes in BGMC connectivity was examined...
September 24, 2016: CNS Neuroscience & Therapeutics
Yi-Ming Deng, Ze-Yu Ding, Yan-Fang Liu, Jian-Wei Wu, Yong-Jun Wang, Xing-Quan Zhao
No abstract text is available yet for this article.
September 24, 2016: CNS Neuroscience & Therapeutics
En-Ze Wu, Xin Liu, David Dornbos, Josef Pfeuffer, Tian-Yi Qian, Peng-Gang Qiao, Yue-Song Pan, Xin Dou, Zhi-Wei Zuo, Li-Ping Liu, Peng Xie
No abstract text is available yet for this article.
September 21, 2016: CNS Neuroscience & Therapeutics
Li-Hua Sun, Fu-Qiang Yang, Chuan-Bao Zhang, Yi-Ping Wu, Jing-Shan Liang, Shuai Jin, Zheng Wang, Hong-Jun Wang, Zhao-Shi Bao, Zheng-Xiang Yang, Tao Jiang
AIMS: To explore the prognostic and clinicopathological features of glioma with Paxillin (PXN) expression based on a large number of samples. METHODS: RNA sequencing data of 325 glioma samples from Chinese Glioma Genome Atlas (CGGA) database were obtained as discovery set. Three additional datasets were further obtained as validation sets. The protein expression pattern of PXN in glioma was measured by IHC. Kaplan-Meier survival and multivariate Cox analysis were used to estimate the survival distributions...
September 17, 2016: CNS Neuroscience & Therapeutics
Gillian M Nixon, Sarah N Biggs, Sonia Jitpiriyaroj, Rosemary S C Horne
No abstract text is available yet for this article.
September 17, 2016: CNS Neuroscience & Therapeutics
Shang-Der Chen, Yen-Yi Zhen, Jui-Wei Lin, Tsu-Kung Lin, Chin-Wei Huang, Chia-Wei Liou, Samuel H H Chan, Yao-Chung Chuang
AIMS: Prolonged seizure activity may result in mitochondrial dysfunction and lead to cell death in the hippocampus. Mitochondrial fission may occur in an early stage of neuronal cell death. This study examined the role of the mitochondrial fission protein dynamin-related protein 1 (Drp1) in the hippocampus following status epilepticus. METHODS: Kainic acid (KA) was microinjected unilaterally into the hippocampal CA3 area in Sprague Dawley rats to induce prolonged seizure activity...
August 31, 2016: CNS Neuroscience & Therapeutics
Arijit Ghosh, Fang Chen, Abhimanyu Thakur, Hao Hong
Cysteinyl leukotrienes are a group of the inflammatory lipid molecules well known as mediators of inflammatory signaling in the allergic diseases. Although they are traditionally known for their role in allergic asthma, allergic rhinitis, and others, recent advances in the field of biomedical research highlighted the role of these inflammatory mediators in a broader range of diseases such as in the inflammation associated with the central nervous system (CNS) disorders, vascular inflammation (atherosclerotic), and in cancer...
August 19, 2016: CNS Neuroscience & Therapeutics
Xiao-Lin Yang, Bing Chen, Xiao-Qing Zhang, Xin Chen, Mei-Hua Yang, Wei Zhang, Huan-Ran Chen, Zhen-Le Zang, Wei Li, Hui Yang, Shi-Yong Liu
AIM: Infantile spasms (IS) are an age-specific epileptic syndrome with specific clinical symptom and electroencephalogram (EEG) features, lacking treatment options, and a poor prognosis. Excessive endogenous corticotropin-releasing hormone (CRH) in infant brain might result in IS. However, the data from human IS are limited. In our study, we investigated the expressions of CRH and its receptor type 1 (CRHR1) in surgical tissues from patients with IS and autopsy controls. METHODS: Specimens surgically removed from 17 patients with IS, and six autopsy controls were included in the study...
August 18, 2016: CNS Neuroscience & Therapeutics
Maria-Cecilia Lopes, Alexandre C Boronat, Yuan-Pang Wang, Lee Fu-I
OBJECTIVES: To investigate the association between sleep complaints and suicidal behaviors among severely depressed children and adolescents. METHODS: The sample was 214 youths (56.1% males, mean age 12.5 years) with diagnosis of DSM-IV major depressive disorder consecutively recruited from a university-based outpatient clinic specialized in mood disorders. The structured interview for children and adolescents was applied to participants. The Children's Depression Rating Scale-revised version-scored the severity of depression, and the Children's Global Assessment Scale assessed the global functioning...
August 18, 2016: CNS Neuroscience & Therapeutics
David B Clemow, Allen W Nyhuis, Rebecca L Robinson
AIM: To compare atomoxetine (ATX) length of therapy (LoT) among adults with ADHD who reached the recommended dose of 80 mg/day (ATX ≥ 80) versus those who did not (ATX < 80) analyzed separately in patients prescribed ATX as monotherapy (mono) and in combination with other ADHD medications (combo). METHODS: This was a retrospective observational cohort study of the Truven Health Marketscan Commercial Claims Database from January 1, 2006-September 30, 2013, with a 6-month preindex period free of ATX (1st ATX claim as index event) and a 1-year follow-up...
July 31, 2016: CNS Neuroscience & Therapeutics
James C Eisenach, Tony L Yaksh
No abstract text is available yet for this article.
October 2016: CNS Neuroscience & Therapeutics
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