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CNS Neuroscience & Therapeutics

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https://www.readbyqxmd.com/read/30014576/intracerebroventricular-streptozotocin-induced-alzheimer-s-disease-like-sleep-disorders-in-rats-role-of-the-gabaergic-system-in-the-parabrachial-complex
#1
Su-Ying Cui, Jin-Zhi Song, Xiang-Yu Cui, Xiao Hu, Yu-Nu Ma, Yu-Tong Shi, Ying Luo, Yan-Ru Ge, Hui Ding, Hui Ye, Yong-He Zhang
AIM: Sleep disorders are common in Alzheimer's disease (AD) and assumed to directly influence cognitive function and disease progression. This study evaluated sleep characteristics in a rat model of AD that was induced by intracerebroventricular streptozotocin (STZ) administration and assessed the possible underlying mechanisms. METHODS: Cognition ability was assessed in the Morris water maze in rats. Sleep parameters were analyzed by electroencephalographic and electromyographic recordings...
July 16, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29998606/clinical-characteristics-associated-with-therapeutic-nonadherence-of-the-patients-with-major-depressive-disorder-a-report-on-the-national-survey-on-symptomatology-of-depression-in-china
#2
Qian Zhou, Zhi-Guo Wu, Yun Wang, Xiao-Hua Liu, Jun Chen, Yong Wang, You-Song Su, Chen Zhang, Dai-Hui Peng, Wu Hong, Yi-Ru Fang
AIMS: Nonadherence is one of the leading challenges to treatment of the major depressive disorder (MDD). Few studies have systematically analyzed the relationship between clinical characteristics, especially symptoms of depressive patients and their therapeutic nonadherence over a relatively large sample. This study aimed to investigate factors of nonadherence in a nationwide survey in China. METHODS: Participants with MDD who met the criteria of Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) (DSM-IV) were recruited from 32 sites throughout China...
July 11, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29998495/mitochondrial-ataxia-is-genetically-and-phenotypically-heterogeneous
#3
LETTER
Josef Finsterer, Sinda Zarrouk-Mahjoub
No abstract text is available yet for this article.
July 11, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29978947/inaccuracy-in-meta-analysis-on-safety-of-eleven-drugs-for-the-treatment-of-parkinson-s-disease
#4
LETTER
Xian-Wen Chen
No abstract text is available yet for this article.
July 6, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29978554/mgcd0103-a-selective-histone-deacetylase-inhibitor-coameliorates-oligomeric-a%C3%AE-25-35-induced-anxiety-and-cognitive-deficits-in-a-mouse-model
#5
Hei-Jen Huang, Hsin-Yu Huang, Hsiu Mei Hsieh-Li
AIMS: Recently, histone deacetylase (HDAC) inhibitors are considered a possible therapeutic strategy in Alzheimer's disease (AD). However, HDACi treatments exhibit diverse functions with unfavorable effects in AD. Thus, the development of selective HDACi without side effects is urgently needed. METHODS: HDACi, namely, BML210, MGCD0103, PXD101, and Droxinostat, were screened in mouse hippocampal primary cultures incubated with oligomeric Aβ25-35 (50 μmol/L). MGCD0103 was chosen for in vivo tests and was intraperitoneally injected into C57BL/6J mice (0...
July 5, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29963752/social-decision-making-in-autism-on-the-impact-of-mirror-neurons-motor-control-and-imitative-behaviors
#6
REVIEW
Radwa Khalil, Richard Tindle, Thomas Boraud, Ahmed A Moustafa, Ahmed A Karim
The Mirror Neuron System (MNS) plays a crucial role in action perception and imitative behavior, which is suggested to be impaired in Autism Spectrum Disorders (ASDs). In this review, we discuss the plausibility and empirical evidence of a neural interaction between the MNS, action perception, empathy, imitative behavior, and their impact on social decision making in ASDs. To date, there is no consensus regarding a particular theory in ASDs and its underlying mechanisms. Some theories have completely focused on social difficulties, others have emphasized sensory aspects...
July 2, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29962076/pifithrin-%C3%AE-modulates-microglial-activation-and-promotes-histological-recovery-following-spinal-cord-injury
#7
Michael D Caponegro, Luisa F Torres, Cyrus Rastegar, Nisha Rath, Maria E Anderson, John K Robinson, Stella E Tsirka
BACKGROUND: Treatments immediately after spinal cord injury (SCI) are anticipated to decrease neuronal death, disruption of neuronal connections, demyelination, and inflammation, and to improve repair and functional recovery. Currently, little can be done to modify the acute phase, which extends to the first 48 hours post-injury. Efforts to intervene have focused on the subsequent phases - secondary (days to weeks) and chronic (months to years) - to both promote healing, prevent further damage, and support patients suffering from SCI...
July 2, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29962085/metabolic-syndrome-emerges-after-artificial-selection-for-low-baroreflex-sensitivity
#8
Li-Li Zhang, Ying Zhang, Yan-Qiong Cheng, Jing-Ming Zhang, Hong-Qi Liu, Wei-Zhong Wang, Jawahar L Mehta, Zhi-Gang Xiong, Ding-Feng Su, Ai-Jun Liu
AIMS: It is unclear whether the impaired BRS plays a key role in the incidence of cardiovascular diseases. The molecular mechanism of impaired BRS remains to be fully elucidated. We hypothesized that selection of rats based on deficient and normal intrinsic BRS would yield models that reflect cardiovascular diseases risk. METHODS AND RESULTS: Twenty generations of selection produced arterial baroreflex low rats and normal rats that differed in BRS by about 2.5-fold change...
July 1, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29952131/tobacco-and-cannabis-use-in-college-students-are-predicted-by-sex-dimorphic-interactions-between-maoa-genotype-and-child-abuse
#9
Paula J Fite, Shaquanna Brown, Waheeda Hossain, Ann Manzardo, Merlin G Butler, Marco Bortolato
BACKGROUND: Postsecondary students in Western countries exhibit a high prevalence of cannabis and tobacco use disorders. The etiology of these problems is contributed by several psychosocial factors, including childhood adversity and trauma; however, the mechanisms whereby these environmental determinants predispose to the use of these substances remain elusive, due to our poor knowledge of genetic and biological moderators. Converging evidence points to the monoamine oxidase A (MAOA) gene as a moderator of the effects of lifetime stress on the initiation of substance use...
June 27, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29952080/the-impact-of-brain-derived-neurotrophic-factor-val66met-polymorphism-on-cognition-and-functional-brain-networks-in-patients-with-intractable-partial-epilepsy
#10
Meneka K Sidhu, Pamela J Thompson, Britta Wandschneider, Alexandra Foulkes, Jane de Tisi, Jason Stretton, Marina Perona, Maria Thom, Silvia B Bonelli, Jane Burdett, Elaine Williams, John S Duncan, Mar Matarin
INTRODUCTION: Medial temporal lobe epilepsy (mTLE) is the most common refractory focal epilepsy in adults. Around 30%-40% of patients have prominent memory impairment and experience significant postoperative memory and language decline after surgical treatment. BDNF Val66Met polymorphism has also been associated with cognition and variability in structural and functional hippocampal indices in healthy controls and some patient groups. AIMS: We examined whether BDNF Val66Met variation was associated with cognitive impairment in mTLE...
June 27, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29933521/next-generation-sequencing-improves-treatment-efficacy-and-reduces-hospitalization-in-children-with-drug-resistant-epilepsy
#11
Jing Peng, Nan Pang, Ying Wang, Xiao-Le Wang, Jian Chen, Juan Xiong, Pan Peng, Can-Hui Zhu, Miriam Barakael Kessi, Fang He, Fei Yin
BACKGROUND: The purposes of this study were three-fold: (i) to determine the contribution of known genes to the causation of a broad-spectrum of pediatric drug-resistant epilepsy (DRE), (ii) to compare the diagnostic yield and cost among different next-generation sequencing (NGS) approaches, and especially (iii) to assess how NGS approaches can benefit patients by improving diagnosis and treatment efficiency. METHODS: This study enrolled 273 pediatric DRE patients with no obvious acquired etiology...
June 22, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29931740/a-brain-network-model-for-depression-from-symptom-understanding-to-disease-intervention
#12
REVIEW
Bao-Juan Li, Karl Friston, Maria Mody, Hua-Ning Wang, Hong-Bing Lu, De-Wen Hu
Understanding the neural substrates of depression is crucial for diagnosis and treatment. Here, we review recent studies of functional and effective connectivity in depression, in terms of functional integration in the brain. Findings from these studies, including our own, point to the involvement of at least four networks in patients with depression. Elevated connectivity of a ventral limbic affective network appears to be associated with excessive negative mood (dysphoria) in the patients; decreased connectivity of a frontal-striatal reward network has been suggested to account for loss of interest, motivation, and pleasure (anhedonia); enhanced default mode network connectivity seems to be associated with depressive rumination; and diminished connectivity of a dorsal cognitive control network is thought to underlie cognitive deficits especially ineffective top-down control of negative thoughts and emotions in depressed patients...
June 21, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29924477/system-neuroscience-past-present-and-future
#13
REVIEW
Giacomo Rizzolatti, Maddalena Fabbri-Destro, Fausto Caruana, Pietro Avanzini
In this review, we discuss first the anatomical and lesion studies that allowed the localization of fundamental functions in the cerebral cortex of primates including humans. Subsequently, we argue that the years from the end of the Second World War until the end of the last century represented the "golden age" of system neuroscience. In this period, the mechanisms-not only the localization-underlying sensory, and in particular visual functions were described, followed by those underlying cognitive functions and housed in temporal, parietal, and premotor areas...
June 20, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29923314/a-cholecystokinin-b-receptor-antagonist-and-cocaine-interaction-phase-i-study
#14
Ahmed Elkashef, James Robert Brašić, Louis R Cantelina, Roberta Kahn, Nora Chiang, Weiguo Ye, Yun Zhou, Jurij Mojsiak, Kimberly R Warren, Andrew Crabb, John Hilton, Dean F Wong, Frank Vocci
AIMS: RPR 102681, a cholecystokinin-B antagonist, increased dopamine (DA) release and reduced cocaine self-administration in animals. This pilot study sought to assess the safety and pharmacokinetics (PK) of co-administration of RPR 102681 and cocaine, and to confirm the DA release mechanism of RPR 102681. METHODS: Sixteen cocaine-dependent participants were randomized to either placebo or RPR102681 at 3 ascending doses; cocaine was co-administered at steady state of RPR 102681...
June 20, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29911316/de-palmitoylation-by-n-tert-butyl-hydroxylamine-inhibits-ampar-mediated-synaptic-transmission-via-affecting-receptor-distribution-in-postsynaptic-densities
#15
Zhi-Xuan Xia, Zu-Cheng Shen, Shao-Qi Zhang, Ji Wang, Tai-Lei Nie, Qiao Deng, Jian-Guo Chen, Fang Wang, Peng-Fei Wu
AIMS: Palmitoylation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) subunits or their "scaffold" proteins produce opposite effects on AMPAR surface delivery. Considering AMPARs have long been identified as suitable drug targets for central nervous system (CNS) disorders, targeting palmitoylation signaling to regulate AMPAR function emerges as a novel therapeutic strategy. However, until now, much less is known about the effect of palmitoylation-deficient state on AMPAR function...
June 17, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29900692/direct-activation-of-tachykinin-receptors-within-baroreflex-afferent-pathway-and-neurocontrol-of-blood-pressure-regulation
#16
Mei Yuan, Mei-Na Ma, Ting-Yu Wang, Yan Feng, Pei Chen, Chao He, Sijie Liu, Yun-Xia Guo, Yue Wang, Yao Fan, Lu-Qi Wang, Xiao-Qiang E, Guo-Fen Qiao, Bai-Yan Li
AIM: Substance P (SP) causes vasodilation and blood pressure (BP) reduction. However, the involvement of tachykinin receptors (NKRs) within baroreflex afferent pathway in SP-mediated BP regulation is largely unknown. METHODS: Under control and hypertensive condition, NKRs' expressions were evaluated in nodose (NG) and nucleus of tractus solitary (NTS) of male, female, and ovariectomized (OVX) rats; BP was recorded after microinjection of SP and NKRs agonists into NG; Baroreceptor sensitivity (BRS) was tested as well...
June 13, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29898493/frequency-and-clinical-characteristics-of-multiple-sclerosis-rebounds-after-withdrawal-of-fingolimod
#17
LETTER
Maria Eleftheria Evangelopoulos, Andrei Miclea, Lisa Schrewe, Myriam Briner, Anke Salmen, Britta Engelhardt, Andrea Huwiler, Andrew Chan, Robert Hoepner
No abstract text is available yet for this article.
June 13, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29869390/dihydromyricetin-inhibits-microglial-activation-and-neuroinflammation-by-suppressing-nlrp3-inflammasome-activation-in-app-ps1-transgenic-mice
#18
Jie Feng, Jingxue Wang, Yehong Du, Ying Liu, Wei Zhang, Jingfei Chen, Yuanjie Liu, Min Zheng, Kejian Wang, Guiqiong He
BACKGROUND: Activated microglia-mediated inflammation plays a key role in the pathogenesis of Alzheimer's disease (AD). In addition, chronic activation of NLRP3 inflammasomes triggered by amyloid β peptide (Aβ) in microglia contributes to persistent neuroinflammation. Here, the primary goal was to assess whether Dihydromyricetin (DHM), a plant flavonoid compound, is effective therapies for AD; it is crucial to know whether DHM will affect microglial activation and neuroinflammation in APP/PS1 transgenic mice...
June 4, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29858532/intravenous-immunoglobulin-treatment-in-multiple-sclerosis-a-prospective-rater-blinded-analysis-of-relapse-rates-during-pregnancy-and-the-postnatal-period
#19
Alexander Winkelmann, Paulus Stefan Rommer, Michael Hecker, Uwe Klaus Zettl
BACKGROUND: Multiple sclerosis (MS) affects predominantly young women. Currently available disease-modifying drugs have neither been approved during pregnancy nor nursing. AIMS: Evaluating the effect of treatment with intravenous immunoglobulin (IVIg) in MS patients with desire to have a baby. METHODS: In all, 70 MS patients were either treated with IVIg before conception, during first trimester of pregnancy and 12 months postnatal (group I, n = 38) or started IVIg after delivery for 12 months (group II, n = 23) or were untreated (group III, n = 9)...
June 1, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29855151/feasible-stabilization-of-chondroitinase-abc-enables-reduced-astrogliosis-in-a-chronic-model-of-spinal-cord-injury
#20
Andrea Raspa, Edoardo Bolla, Claudia Cuscona, Fabrizio Gelain
AIMS: Usually, spinal cord injury (SCI) develops into a glial scar containing extracellular matrix molecules including chondroitin sulfate proteoglycans (CSPGs). Chondroitinase ABC (ChABC), from Proteus vulgaris degrading the glycosaminoglycan (GAG) side chains of CSPGs, offers the opportunity to improve the final outcome of SCI. However, ChABC usage is limited by its thermal instability, requiring protein structure modifications, consecutive injections at the lesion site, or implantation of infusion pumps...
May 31, 2018: CNS Neuroscience & Therapeutics
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