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CNS Neuroscience & Therapeutics

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https://www.readbyqxmd.com/read/29777578/sirt3-deficiency-impairs-neurovascular-recovery-in-ischemic-stroke
#1
Xiao Yang, Ke-Yi Geng, Yan-Shuang Zhang, Jin-Fan Zhang, Ke Yang, Jia-Xiang Shao, Wei-Liang Xia
AIMS: Sirt3 is one member of the NAD+ -dependent protein deacetylase family and plays crucial roles in diverse aspects of mammalian biological function. Then the role of Sirt3 on ischemia stroke is unknown. METHODS: To examine the effect of Sirt3 on ischemic stroke, we performed transient middle cerebral artery occlusion (tMCAO) in adult male Sirt3 knockout (KO) and wild-type (WT) mice. RESULTS: The level of Sirt3 in infarct region is decreased after ischemic stroke...
May 18, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29770579/cholinesterase-targeting-by-polyphenols-a-therapeutic-approach-for-the-treatment-of-alzheimer-s-disease
#2
REVIEW
Nasimudeen R Jabir, Fayaz Rahman Khan, Shams Tabrez
Alzheimer's disease (AD) is a progressive irreversible neurodegenerative disorder characterized by excessive deposition of β-amyloid (Aβ) oligomers, and neurofibrillary tangles (NFTs), comprising of hyperphosphorylated tau proteins. The cholinergic system has been suggested as the earliest and most affected molecular mechanism that describes AD pathophysiology. Moreover, cholinesterase inhibitors (ChEIs) are the potential class of drugs that can amplify cholinergic activity to improve cognition and global performance and reduce psychiatric and behavioral disturbances...
May 16, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29767470/early-increase-of-neutrophil-to-lymphocyte-ratio-predicts-30-day-mortality-in-patients-with-spontaneous-intracerebral-hemorrhage
#3
Fei Wang, Feng Xu, Ye Quan, Li Wang, Jian-Jun Xia, Ting-Ting Jiang, Li-Juan Shen, Wen-Hui Kang, Yong Ding, Li-Xia Mei, Xue-Feng Ju, Shan-You Hu, Xiao Wu
AIMS: To examine whether early rise of neutrophil-to-lymphocyte ratio (NLR) after patient hospitalization correlates with 30-day mortality in patients with spontaneous intracerebral hemorrhage (ICH). METHODS: This retrospective study included all patients receiving treatment for spontaneous ICH between January 2015 and September 2016 at the Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences in Shanghai, China. NLR was determined at admission (T1), at 24-48 hours (T2) and 5-7 days (T3)...
May 16, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29766653/organic-psychosis-the-pathobiology-and-treatment-of-delusions
#4
REVIEW
Eileen Maria Joyce
Organic or secondary psychosis can be seen in diverse conditions such as toxic/metabolic disorders, neurodegenerative disease, and stroke. Poststroke psychosis is a rare phenomenon, but its study has significantly contributed to the understanding of delusion formation. The evidence from case studies of patients with focal strokes shows that delusions develop following unilateral damage of the right hemisphere. The majority of patients with right hemisphere stroke do not develop delusions however, and advanced neuroimaging analysis has elucidated why this symptom develops in only a small proportion...
May 15, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29761665/the-effect-of-v-atpase-function-defects-in-pathogenesis-of-alzheimer-s-disease
#5
LETTER
Zi-Wei Zhao, Zhen Yuan, De-Qiang Zhao, Zhan-Wen Wang, Fei-Qi Zhu, Ping Luan
No abstract text is available yet for this article.
May 14, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29761646/hydroxychloroquine-fails-to-attenuate-lesion-development-in-a-mouse-model-of-neuromyelitis-optica
#6
LETTER
Ling Fang, Zhen Wang, Huan-Huan Song, Yi-Fan Zhou, Chen Chen, Ya-Ping Yan, Wei Qiu
No abstract text is available yet for this article.
May 14, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29756269/genetic-and-clinical-features-of-chinese-patients-with-mitochondrial-ataxia-identified-by-targeted-next-generation-sequencing
#7
Hai-Lin Dong, Yin Ma, Quan-Fu Li, Yi-Chu Du, Lu Yang, Sheng Chen, Zhi-Ying Wu
AIM: To characterize the mutations in mitochondrial DNA (mtDNA) and mitochondrion-related nuclear genes (nDNA), and clinical features in Chinese patients with mitochondrial ataxia. METHODS: Targeted next-generation sequencing (NGS) technology was performed to screen the whole mtDNA sequence and nDNA genes in a cohort of 33 unrelated ataxia patients. RESULTS: A total of 5 pedigrees were finally genetically diagnosed as mitochondrial ataxia, with 3 pathogenic mutations (m...
May 13, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29729086/the-novel-atypical-antipsychotic-cariprazine-demonstrates-dopamine-d-2-receptor-dependent-partial-agonist-actions-on-rat-mesencephalic-dopamine-neuronal-activity
#8
Sarah Delcourte, Charles R Ashby, Renaud Rovera, Béla Kiss, Nika Adham, Bence Farkas, Nasser Haddjeri
AIM: Cariprazine, a dopamine D3 -preferring D3 /D2 receptor partial agonist, is FDA approved for the treatment of schizophrenia and acute manic or mixed episodes of bipolar disorder. This study used in vivo electrophysiological techniques in anesthetized rats to determine cariprazine's effect on dopaminergic cell activity in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc). METHODS: Extracellular recordings of individual dopaminergic neurons were performed after oral or intravenous administration of cariprazine, the D3 receptor antagonist SB 277011A, the D2 receptor antagonist L741,626, and/or the D3 receptor agonist PD 128,907...
May 4, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29722152/modulation-of-forebrain-function-by-nucleus-incertus-and-relaxin-3-rxfp3-signaling
#9
REVIEW
Francisco E Olucha-Bordonau, Héctor Albert-Gascó, Francisco Ros-Bernal, Valeria Rytova, Emma K E Ong-Pålsson, Sherie Ma, Ana M Sánchez-Pérez, Andrew L Gundlach
The nucleus incertus (NI) in the pontine tegmentum sends ascending projections to the midbrain, hypothalamus, amygdala, basal forebrain, hippocampus, and prefrontal cortex, and has a postulated role in modulating several forebrain functions. A substantial population of GABAergic NI neurons expresses the neuropeptide, relaxin-3, which acts via the Gi/o -protein-coupled receptor, RXFP3, present throughout the forebrain target regions. Broad and specific manipulations of these systems by activation or inhibition of the NI or modulating RXFP3 signaling have revealed key insights into the likely influence of the NI/relaxin-3/RXFP3 system on modalities including arousal, feeding, stress responses, anxiety and addiction, and attention and memory...
May 2, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29722134/a-novel-pde9-inhibitor-wyq-c36d-ameliorates-corticosterone-induced-neurotoxicity-and-depression-like-behaviors-by-cgmp-creb-related-signaling
#10
Xian-Feng Huang, Wen-Tao Jiang, Li Liu, Fang-Chen Song, Xia Zhu, Gui-Lan Shi, Shu-Ming Ding, Heng-Ming Ke, Wei Wang, James M O'Donnell, Han-Ting Zhang, Hai-Bin Luo, Yi-Qian Wan, Guo-Qiang Song, Ying Xu
BACKGROUND: Major depressive disorder (MDD) is a mental disease characterized by depressed mood, lifetime anxiety, and deficits of learning and memory. Inhibition of phosphodiesterase 9 (PDE9) has been reported to improve rodent cognitive and memory function. However, the role of PDE9 in MDD, in particular its manifestations of depression and anxiety, has not been investigated. METHODS: We examined the protective effects of WYQ-C36D (C36D), a novel PDE9 inhibitor, against corticosterone-induced cytotoxicity, pCREB/CREB and BDNF expression by cell viability, and immunoblot assays in HT-22 cells...
May 2, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29704309/the-neuroprotective-and-antidepressant-like-effects-of-hcyb1-a-novel-selective-pde2-inhibitor
#11
Li Liu, Jing Zheng, Xian-Feng Huang, Xia Zhu, Shu-Ming Ding, Heng-Ming Ke, James M O'Donnell, Han-Ting Zhang, Guo-Qiang Song, Ying Xu
AIMS: Depression is currently the most common mood disorder. Regulation of intracellular cyclic adenosine monophosphate (cAMP) and/or cyclic guanosine monophosphate (cGMP) signaling by phosphodiesterase (PDE) inhibition has been paid much attention for treatment of depression. This study aimed to investigate the neuroprotective effects of Hcyb1, a novel PDE2 inhibitor, in HT-22 cells and antidepressant-like effects in mouse models of depression. METHODS: Hcyb1 was synthesized and its selectivity upon PDE2 was tested...
April 27, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29691990/altered-functional-connectivity-strength-and-its-correlations-with-cognitive-function-in-subjects-with-ultra-high-risk-for-psychosis-at-rest
#12
Ran-Ran Li, Hai-Long Lyu, Feng Liu, Nan Lian, Ren-Rong Wu, Jing-Ping Zhao, Wen-Bin Guo
AIMS: Evidence of altered structural and functional connectivity in the frontal-occipital network is associated with cognitive deficits in patients with schizophrenia. However, the altered patterns of functional connectivity strength (FCS) in individuals with ultra-high risk (UHR) for psychosis remain unknown. In this study, whole-brain FCS was assessed to examine the altered patterns of FCS in UHR subjects. METHODS: A total of 34 UHR subjects and 37 age- and sex-matched healthy controls were enrolled to undergo resting-state functional magnetic resonance imaging...
April 24, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29691988/insulin-receptor-in-the-brain-mechanisms-of-activation-and-the-role-in-the-cns-pathology-and-treatment
#13
REVIEW
Igor Pomytkin, João P Costa-Nunes, Vladimir Kasatkin, Ekaterina Veniaminova, Anna Demchenko, Alexey Lyundup, Klaus-Peter Lesch, Eugene D Ponomarev, Tatyana Strekalova
While the insulin receptor (IR) was found in the CNS decades ago, the brain was long considered to be an insulin-insensitive organ. This view is currently revisited, given emerging evidence of critical roles of IR-mediated signaling in development, neuroprotection, metabolism, and plasticity in the brain. These diverse cellular and physiological IR activities are distinct from metabolic IR functions in peripheral tissues, thus highlighting region specificity of IR properties. This particularly concerns the fact that two IR isoforms, A and B, are predominantly expressed in either the brain or peripheral tissues, respectively, and neurons express exclusively IR-A...
April 24, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29687641/genetic-rescue-of-absence-seizures
#14
LETTER
Cian McCafferty, William M Connelly, Roberta Celli, Richard T Ngomba, Ferdinando Nicoletti, Vincenzo Crunelli
No abstract text is available yet for this article.
April 23, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29687627/anhedonia-in-depression-and-schizophrenia-a-transdiagnostic-challenge
#15
Clare Lambert, Susana Da Silva, Amanda K Ceniti, Sakina J Rizvi, George Foussias, Sidney H Kennedy
BACKGROUND: Anhedonia, as a dysregulation of the reward circuit, is present in both Major Depressive Disorder (MDD) and schizophrenia (SZ). AIMS: To elucidate the clinical and neurobiological differences between schizophrenia (SZ) and depression (MDD) in regard to anhedonia, while reconciling the challenges and benefits of assessing anhedonia as a transdiagnostic feature under the Research Domain Criteria (RDoC) framework. METHODS: In this review, we summarize data from publications examining anhedonia or its underlying reward deficits in SZ and MDD...
April 23, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29687623/serum-sodium-potassium-and-magnesium-in-children-with-epilepsy-treated-with-levetiracetam-monotherapy-a-prospective-study
#16
LETTER
Achilleas Attilakos, Anastasia Garoufi, Maria Paschalidou, Maria Tsirouda, Nikos Siafakas, Argiris Dinopoulos
No abstract text is available yet for this article.
April 23, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29687619/understanding-jugular-venous-outflow-disturbance
#17
REVIEW
Da Zhou, Jia-Yue Ding, Jing-Yuan Ya, Li-Qun Pan, Feng Yan, Qi Yang, Yu-Chuan Ding, Xun-Ming Ji, Ran Meng
Extracranial venous abnormalities, especially jugular venous outflow disturbance, were originally viewed as nonpathological phenomena due to a lack of realization and exploration of their feature and clinical significance. The etiology and pathogenesis are still unclear, whereas a couple of causal factors have been conjectured. The clinical presentation of this condition is highly variable, ranging from insidious to symptomatic, such as headaches, dizziness, pulsatile tinnitus, visual impairment, sleep disturbance, and neck discomfort or pain...
April 23, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29667327/novel-west-syndrome-candidate-genes-in-a-chinese-cohort
#18
Jing Peng, Ying Wang, Fang He, Chen Chen, Li-Wen Wu, Li-Fen Yang, Yu-Ping Ma, Wen Zhang, Zi-Qing Shi, Chao Chen, Kun Xia, Hui Guo, Fei Yin, Nan Pang
AIMS: West syndrome (WS) is a classic form of early infantile epileptic encephalopathy (EIEE) characterized by tonic spasms with clustering, arrest of psychomotor development, and hypsarrhythmia on electroencephalography. Genetic defects play a critical role in the pathology of WS, and 54 EIEE genes have been identified till date. This study was designed to uncover new candidate genes for West syndrome. METHODS: In this study, we recruited 56 Chinese families with WS of unknown etiology...
April 17, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29656591/amp-activated-protein-kinase-dependent-induction-of-autophagy-by-erythropoietin-protects-against-spinal-cord-injury-in-rats
#19
Peng Wang, Zhong-Dong Xie, Chang-Nan Xie, Chao-Wei Lin, Ji-Li Wang, Li-Na Xuan, Chun-Wu Zhang, Yu Wang, Zhi-Hui Huang, Hong-Lin Teng
AIMS: Autophagy has been regarded as a promising therapeutic target for spinal cord injury (SCI). Erythropoietin (EPO) has been demonstrated to exhibit neuroprotective effects in the central nervous system (CNS); however, the molecular mechanisms of its protection against SCI remain unknown. This study aims to investigate whether the neuroprotective effects of EPO on SCI are mediated by autophagy via AMP-activated protein kinase (AMPK) signaling pathways. METHODS: Functional assessment and Nissl staining were used to investigate the effects of EPO on SCI...
April 15, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29656444/predicting-therapeutic-response-to-fingolimod-treatment-in-multiple-sclerosis-patients
#20
Bibiana Quirant-Sánchez, José V Hervás-García, Aina Teniente-Serra, Luis Brieva, Ester Moral-Torres, Antonio Cano, Elvira Munteis, María J Mansilla, Silvia Presas-Rodriguez, Juan Navarro-Barriuso, Cristina Ramo-Tello, Eva M Martínez-Cáceres
AIMS: Fingolimod, an orally active immunomodulatory drug for relapsing-remitting multiple sclerosis (RRMS), sequesters T cells in lymph nodes through functional antagonism of the sphingosine-1-phosphate receptor, reducing the number of potential autoreactive cells that migrate to the central nervous system. However, not all RRMS patients respond to this therapy. Our aim was to test the hypothesis that by immune-monitoring RRMS patient's leukocyte subpopulations it is possible to find biomarkers associated with clinical response to fingolimod...
April 15, 2018: CNS Neuroscience & Therapeutics
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