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Prion

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https://www.readbyqxmd.com/read/30223705/combined-findings-of-fdg-pet-and-arterial-spin-labeling-in-sporadic-creutzfeldt-jakob-disease
#1
Junliang Yuan, Shuangkun Wang, Wenli Hu
Sporadic Creutzfeldt-Jakob disease (sCJD) is a fatal progressive neurodegenerative disease. Multimodal approaches, including electroencephalogram, diffusion-weighted imaging (DWI) of brain MRI, and cerebrospinal fluid biomarkers, have been applied to increase the diagnostic accuracy of sCJD. Although previous studies suggested DWI could be the most useful modality for sCJD diagnosis, whether metabolism changes underlying in sCJD are still poorly understood. To the best of our knowledge, there are only one case using the technique of arterial spin labeling (ASL) to detection and follow-up of perfusion changes in CJD...
September 18, 2018: Prion
https://www.readbyqxmd.com/read/30223704/a-simple-in-vitro-assay-for-assessing-the-efficacy-mechanisms-and-kinetics-of-anti-prion-fibril-compounds
#2
Carol L Ladner-Keay, Li Ross, Rolando Perez-Pineiro, Lun Zhang, Trent C Bjorndahl, Neil Cashman, David S Wishart
Prion diseases are caused by the conversion of normal cellular prion proteins (PrP) into lethal prion aggregates. These prion aggregates are composed of proteinase K (PK) resistant fibrils and comparatively PK-sensitive oligomers. Currently there are no anti-prion pharmaceuticals available to treat or prevent prion disease. Methods of discovering anti-prion molecules rely primarily on relatively complex cell-based, tissue slice or animal-model assays that measure the effects of small molecules on the formation of PK-resistant prion fibrils...
September 18, 2018: Prion
https://www.readbyqxmd.com/read/30220236/a-standard-model-of-alzheimer-s-disease
#3
Lary C Walker, David G Lynn, Yury O Chernoff
The recent Research Framework proposed by the US National Institute on Aging and the Alzheimer's Association (NIA-AA) recommends that Alzheimer's disease be defined by its specific biology rather than by non-specific neurodegenerative and syndromal features. By affirming markers of abnormal Aβ and tau proteins as the essential pathobiological signature of Alzheimer's disease, the Framework tacitly reinforces the amyloid (Aβ) cascade as the leading theory of Alzheimer pathogenesis. In light of recent evidence that the cascade is driven by the misfolding and templated aggregation of Aβ and tau, we believe that an empirically grounded Standard Model of Alzheimer's pathogenesis is within reach...
September 17, 2018: Prion
https://www.readbyqxmd.com/read/30165789/yeast-based-screening-of-natural-product-extracts-results-in-the-identification-of-prion-inhibitors-from-a-marine-sponge
#4
Laurence K Jennings, Ishtiaq Ahmed, Alan L Munn, Anthony R Carroll
One of the major medical challenges of the twenty-first century is the treatment of incurable and fatal neurodegenerative disorders caused by misfolded prion proteins. Since the discovery of these diseases a number of studies have been conducted to identify small molecules for their treatment, however to date no curative treatment is available. These studies can be highly expensive and time consuming, but more recent experimental approaches indicate a significant application for yeast prions in these studies...
September 13, 2018: Prion
https://www.readbyqxmd.com/read/30165784/the-first-report-of-polymorphisms-and-genetic-characteristics-of-the-prion-protein-gene-prnp-in-horses
#5
Yong-Chan Kim, Byung-Hoon Jeong
Prion diseases have a wide host range, but prion-infected cases have never been reported in horses. Genetic polymorphisms that can directly impact the structural stability of horse prion protein have not been investigated thus far. In addition, we noticed that previous studies focusing on horse-specific amino acids and secondary structure predictions of prion protein were performed for limited parts of the protein. In this study, we found genetic polymorphisms in the horse prion protein gene (PRNP) in 201 Thoroughbred horses...
September 12, 2018: Prion
https://www.readbyqxmd.com/read/30149773/14-3-3-and-enolase-abundances-in-the-csf-of-prion-diseased-rats
#6
Danielle Gushue, Allen Herbst, Valerie Sim, Debbie McKenzie, Judd M Aiken
Creutzfeldt-Jakob disease (CJD) is characterized by an extended asymptomatic preclinical phase followed by rapid neurodegeneration. There are no effective treatments. CJD diagnosis is initially suspected based upon the clinical presentation of the disease and the exclusion of other etiologies. Neurologic symptoms are assessed in combination with results from cerebrospinal fluid (CSF) biomarker abundances, electroencephalography (EEG), magnetic resonance imaging (MRI), and in some countries, real-time quaking-induced conversion (RT-QuIC)...
September 12, 2018: Prion
https://www.readbyqxmd.com/read/30198379/proteolysis-a-double-edged-sword-for-the-development-of-amyloidoses
#7
Atsushi Okamoto, Nao Hosoda, Shin-Ichi Hoshino
The yeast Saccharomyces cerevisiae has proven to be a useful model system to investigate the mechanism of prion generation and inheritance, to which studies in Sup35 made a great contribution. Recent studies demonstrated that "protein misfolding and aggregation" (i.e. amyloidogenesis) is a common principle underlying the pathogenesis of neurodegenerative diseases including prion, amyotrophic lateral sclerosis (ALS), Perkinson's (PD), Alzheimer's (AD) diseases and polyglutamine (polyQ) diseases such as spinocerebellar ataxia (SCA) and Hantington's disease (HD)...
September 9, 2018: Prion
https://www.readbyqxmd.com/read/30196749/prion-based-nanomaterials-and-their-emerging-applications
#8
Marta Díaz-Caballero, Maria Rosario Fernandez, Susanna Navarro, Salvador Ventura
Protein misfolding and aggregation into highly ordered fibrillar structures have been traditionally associated with pathological processes. Nevertheless, nature has taken advantage of the particular properties of amyloids for functional purposes, like in the protection of organisms against environmental changing conditions. Over the last decades, these fibrillar structures have inspired the design of new nanomaterials with intriguing applications in biomedicine and nanotechnology such as tissue engineering, drug delivery, adhesive materials, biodegradable nanocomposites, nanowires or biosensors...
September 8, 2018: Prion
https://www.readbyqxmd.com/read/30074430/poly-l-histidine-inhibits-prion-propagation-in-a-prion-infected-cell-line
#9
Ryo Honda, Kei-Ichi Yamaguchi, Abdelazim Elsayed Elhelaly, Mitsuhiko Fuji, Kazuo Kuwata
Transmissible spongiform encephalopathies (TSEs) are a group of lethal neurodegenerative diseases involving the structural conversion of cellular prion protein (PrPC ) into the pathogenic isoform (PrPSc ) for which no effective treatment is currently available. Previous studies have implicated that a polymeric molecule with a repeating unit, such as pentosane polysulfate and polyamidoamide dendrimers, exhibits a potent anti-prion activity, suggesting that poly-(amino acid)s could be a candidate molecule for inhibiting prion propagation...
August 17, 2018: Prion
https://www.readbyqxmd.com/read/30080439/unexpected-prion-phenotypes-in-experimentally-transfused-animals-predictive-models-for-humans
#10
Emmanuel E Comoy, Jacqueline Mikol, Jean-Philippe Deslys
The recently reevaluated high prevalence of healthy carriers (1/2,000 in UK) of variant Creutzfeldt-Jakob Disease (v-CJD), whose blood might be infectious, suggests that the evolution of this prion disease might not be under full control as expected. After experimental transfusion of macaques and conventional mice with blood derived from v-CJD exposed (human and animal) individuals, we confirmed in these both models the transmissibility of v-CJD, but we also observed unexpected neurological syndromes transmissible by transfusion: despite their prion etiology confirmed through transmission experiments, these original cases would escape classical prion diagnosis, notably in the absence of detectable abnormal PrP with current techniques...
August 16, 2018: Prion
https://www.readbyqxmd.com/read/30074427/the-same-but-different-the-role-of-hsp70-in-heat-shock-response-and-prion-propagation
#11
Linan Xu, Weibin Gong, Hong Zhang, Sarah Perrett, Gary W Jones
The Hsp70 chaperone machinery is a key component of the heat-shock response and a modulator of prion propagation in yeast. A major factor in optimizing Hsp70 function is the highly coordinated activities of the nucleotide-binding and substrate-binding domains of the protein. Hsp70 inter-domain communication occurs through a bidirectional allosteric interaction network between the two domains. Recent findings identified the β6/β7 region of the substrate-binding domain as playing a critical role in optimizing Hsp70 function in both the stress response and prion propagation and highlighted the allosteric interaction interface between the domains...
August 16, 2018: Prion
https://www.readbyqxmd.com/read/30009661/altered-gene-transcription-linked-to-astrocytes-and-oligodendrocytes-in-frontal-cortex-in-creutzfeldt-jakob-disease
#12
Pol Andres Benito, Mayelin Dominguez Gonzalez, Isidro Ferrer
Targeted expression of genes coding for proteins specific to astrocytes, oligodendrocytes and myelin was performed in frontal cortex area 8 of Creutzfeldt-Jakob disease methionine/methionine and valine/valine (CJD MM1 and VV2, respectively) compared with controls. GFAP (glial fibrillary acidic protein) mRNA was up-regulated whereas SLC1A2 (solute carrier family 1 member 2, coding for glutamate transporter 1: GLT1), AQ4 (aquaporin 4), MPC1 (mitochondrial pyruvate carrier 1) and UCP5 (mitochondrial uncoupled protein 5) mRNAs were significantly down-regulated in CJD MM1 and CJD VV2, and GJA1 (connexin 43) in CJD VV2...
July 27, 2018: Prion
https://www.readbyqxmd.com/read/30041562/influence-of-the-geographic-distribution-of-prion-protein-gene-sequence-variation-on-patterns-of-chronic-wasting-disease-spread-in-white-tailed-deer-odocoileus-virginianus
#13
Adam L Brandt, Michelle L Green, Yasuko Ishida, Alfred L Roca, Jan Novakofski, Nohra E Mateus-Pinilla
Managing and controlling the spread of diseases in wild animal populations is challenging, especially for social and mobile species. Effective management benefits from information about disease susceptibility, allowing limited resources to be focused on areas or populations with a higher risk of infection. Chronic wasting disease (CWD), a transmissible spongiform encephalopathy that affects cervids, was detected in Colorado in the late 1960s. CWD was detected in Illinois and Wisconsin in 2002 and has since spread through many counties...
July 25, 2018: Prion
https://www.readbyqxmd.com/read/29923447/microbial-specialization-by-prions
#14
Gregory A Newby, Can Kayatekin
Microbial prions facilitate a variety of phenotypic switches. Recently-developed tools that can directly interrogate, in the living cell, the aggregation state of a protein have enabled a wider range of experiments for prion-mediated behaviors. With such tools, the roles of the yeast prion [SWI+ ] in migration and mating were studied. Although [SWI+ ] cells were consistently less fit than their [swi- ] counterparts under traditional laboratory conditions, in these new phenotypic paradigms [SWI+ ] cells demonstrated a distinct advantage...
July 24, 2018: Prion
https://www.readbyqxmd.com/read/29966485/the-first-report-of-genetic-variations-in-the-chicken-prion-protein-gene
#15
Yong-Chan Kim, Min-Ju Jeong, Byung-Hoon Jeong
Abnormal structural changes of the prion protein (PrP) are the cause of prion disease in a wide range of mammals. However, spontaneous infected cases have not been reported in chicken. Genetic variations of the prion protein gene (PRNP) may impact susceptibility to prion disease but have not been investigated thus far. Because an investigation of the chicken PRNP can improve the understanding of characteristics related to resistance to prion disease, research on the chicken PRNP is highly desirable. In this study, we investigated the genetic characteristics of the chicken PRNP gene...
July 14, 2018: Prion
https://www.readbyqxmd.com/read/29676187/decrease-of-ryr2-in-the-prion-infected-cell-line-and-in-the-brains-of-the-scrapie-infected-mice-models-and-the-patients-of-human-prion-diseases
#16
Qi Shi, Jian-Le Li, Yue Ma, Li-Ping Gao, Kang Xiao, Jing Wang, Wei Zhou, Cao Chen, Yan-Jun Guo, Xiao-Ping Dong
The levels of ryanodine receptors (RyRs) are usually increased in the brains of human Alzheimer disease (AD) and AD animal models. To evaluate the underlying alteration of brain RyRs in prion disease, scrapie infected cell line SMB-S15 and its infected mice were tested. RyR2 specific Western blots revealed markedly decreased RyR2 levels both in the cells and in the brains of infected mice. Assays of the brain samples of other scrapie (agents 139A and ME7) infected mice collected at different time-points during incubation period showed time-dependent decreases of RyR2...
June 7, 2018: Prion
https://www.readbyqxmd.com/read/29695200/nucleotide-variants-in-prion-related-protein-testis-specific-gene-prnt-and-effects-on-chinese-and-mongolian-sheep-phenotypes
#17
Jie Li, Shaoli Zhang, Sarantsetseg Erdenee, Xiuzhu Sun, Ruihua Dang, Yongzhen Huang, Chuzhao Lei, Hong Chen, Hongwei Xu, Yong Cai, Xianyong Lan
Studies of the ovine prion-related protein (testis-specific) gene (PRNT), including studies of genetic diversity, have highlighted its potential relationship to scrapie infection and economically important ovine traits. PRNT was previously reported to be highly polymorphic in Portuguese sheep. To characterize genetic polymorphisms in this gene in Asian sheep, a direct sequencing method was used to detect polymorphic loci in PRNT in 285 individual sheep from four Chinese and one Mongolian breeds. Seven SNP variants in PRNT were identified, including three novel variants (g...
June 5, 2018: Prion
https://www.readbyqxmd.com/read/29676205/effects-of-peptidyl-prolyl-isomerase-1-depletion-in-animal-models-of-prion-diseases
#18
Giuseppe Legname, Tommaso Virgilio, Edoardo Bistaffa, Chiara Maria Giulia De Luca, Marcella Catania, Paola Zago, Elisa Isopi, Ilaria Campagnani, Fabrizio Tagliavini, Giorgio Giaccone, Fabio Moda
Pin1 is a peptidyl-prolyl isomerase that induces the cis-trans conversion of specific Ser/Thr-Pro peptide bonds in phosphorylated proteins, leading to conformational changes through which Pin1 regulates protein stability and activity. Since down-regulation of Pin1 has been described in several neurodegenerative disorders, including Alzheimer's Disease (AD), Parkinson's Disease (PD) and Huntington's Disease (HD), we investigated its potential role in prion diseases. Animals generated on wild-type (Pin1+/+ ), hemizygous (Pin1+/- ) or knock-out (Pin1-/- ) background for Pin1 were experimentally infected with RML prions...
March 4, 2018: Prion
https://www.readbyqxmd.com/read/29644924/role-of-prion-protein-egfr-multimolecular-complex-during-neuronal-differentiation-of-human-dental-pulp-derived-stem-cells
#19
Stefano Martellucci, Valeria Manganelli, Costantino Santacroce, Francesca Santilli, Luca Piccoli, Maurizio Sorice, Vincenzo Mattei
Cellular prion protein (PrPC ) is expressed in a wide variety of stem cells in which regulates their self-renewal as well as differentiation potential. In this study we investigated the presence of PrPC in human dental pulp-derived stem cells (hDPSCs) and its role in neuronal differentiation process. We show that hDPSCs expresses early PrPC at low concentration and its expression increases after two weeks of treatment with EGF/bFGF. Then, we analyzed the association of PrPC with gangliosides and EGF receptor (EGF-R) during neuronal differentiation process...
March 4, 2018: Prion
https://www.readbyqxmd.com/read/29633896/therpa-a-small-molecule-database-related-to-prion-protein-regulation-and-prion-diseases-progression
#20
Sol Moe Lee, Wonseok Lee, Yeong Seon Lee, Jin-Soo Yoo, Soo-Jung Park, Heebal Kim, Su Yeon Kim
Prion diseases are fatal neurodegenerative disorders that affect humans and animals. Although various small molecules have been evaluated for application in the treatment of prion diseases, none have been shown to be efficacious. Expanding our knowledge of these molecules is important for understanding of the complex mechanisms of prion diseases. To improve access to the scattered information on small molecules related to prion diseases, we built a database of therapeutic molecules associated with prion diseases (THERPA, therpa...
March 4, 2018: Prion
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