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International Journal of Clinical and Experimental Medicine

Brian C Jensen, Scott J Bultman, Darcy Holley, Wei Tang, Gustaaf de Ridder, Salvatore Pizzo, Dawn Bowles, Monte S Willis
The cellular environment of the mammalian heart constantly is challenged with environmental and intrinsic pathological insults, which affect the proper folding of proteins in heart failure. The effects of damaged or misfolded proteins on the cell can be profound and result in a process termed "proteotoxicity". While proteotoxicity is best known for its role in mediating the pathogenesis of neurodegenerative diseases such as Alzheimer's disease, its role in human heart failure also has been recognized. The UPR involves three branches, including PERK, ATF6, and IRE1...
2017: International Journal of Clinical and Experimental Medicine
Tae-Dong Kim, Sangphil Oh, Stan A Lightfoot, Sook Shin, Jonathan D Wren, Ralf Janknecht
PSMD10, also known as gankyrin, is associated with the proteasome and has been shown to be an oncoprotein in the liver. Here, we report that PSMD10 expression is stimulated by the histone demethylase JMJD2A/KDM4A and its interaction partner, the ETV1 transcription factor, in LNCaP prostate cancer cells. Global analysis of expression patterns revealed that PSMD10 mRNA levels are positively correlated with those of both JMJD2A and ETV1. In human prostate tumors, PSMD10 is highly overexpressed at the protein level and correlates with JMJD2A overexpression; further, PSMD10 expression is enhanced in the prostates of transgenic JMJD2A mice...
2016: International Journal of Clinical and Experimental Medicine
(no author information available yet)
[This retracts the article on p. 11428 in vol. 8, PMID: 26379959.].
2015: International Journal of Clinical and Experimental Medicine
Yujian Niu, Wenxin Zhang, Sha Mao, Yanhong Gao, Jianli Wang, Jun Li, Letian Wang, Zhaojie Guan, Zhongyang Shen
OBJECTIVE: To explore the feasibility of the Chinese version of Kidney Transplant Questionnaire (KTQ) by evaluating the health-related quality of life (HRQoL) in Chinese recipients of living donor kidney transplantation. METHODS: The English version of KTQ was translated into Chinese and underwent cultural adaptation to obtain the Chinese version of KTQ. HRQoL of 136 Chinese recipients of living donor kidney transplantation that met the inclusion criteria were evaluated to assess the validity and reliability of the questionnaire...
2015: International Journal of Clinical and Experimental Medicine
Umit Yavuz Malkan, Gursel Gunes, Eylem Eliacik, Ibrahim Celalettin Haznedaroglu, Sezgin Etgul, Tuncay Aslan, Okan Yayar, Seda Aydin, Haluk Demiroglu, Osman Ilhami Ozcebe, Nilgun Sayinalp, Hakan Goker, Salih Aksu, Yahya Buyukasik
There are some improvements in management of acute myeloid leukemia (AML). However, induction-induced deaths still remain as a major problem. The aim of this study is to assess clinical parameters affecting early death in patients with AML. 199 AML patients, who were treated with intensive, non-intensive or supportive treatment between 2002 and 2014 in Hacettepe Hematology Department, were analyzed retrospectively. In our study early death rate for elderly was found to be lower than previous reports whereas it was similar for those who were under age of 60...
2015: International Journal of Clinical and Experimental Medicine
Esra Akyüz Özkan, Hashem E Khosroshahi, Halil İbrahim Serin, Zeynep Tuba Özdemir, Mahmut Kılıç, Meral Ekim, U Aliye Geçit, Esra Domur
BACKGROUND: Obesity is associated with many risk factors, such as hyperlipidemia, hyperinsulinemia, hypertension and leads to early atherosclerosis. The aim of this study was to investigate the relation of the mean platelet volume (MPV) and the carotid intima media thickness (CIMT) on cardiac functions among obese children. MATERIALS AND METHODS: Sixty obese children, with body mass index percentile were >95% and forty eight healthy controls were enrolled in the study...
2015: International Journal of Clinical and Experimental Medicine
Hongbin Gu, Jie Bai, Jinfen Liu
OBJECTIVE: To determine effects of DEX versus propofol on saturation of pulse oximetry (SPO2) in children with Tetralogy of Fallot (TOF) during anesthesia. METHODS: 54 children with TOF who planned to receive corrected operation were randomly assigned to two groups: group DEX and group Propofol. Indicators were compared at T0 (immediate induction of anesthesia), T1 (tracheal catheterization), T2 (skin incision), T3 (sternal exposure) and T4 (aortic catheterization)...
2015: International Journal of Clinical and Experimental Medicine
Hilal Olgun Küçük, Uğur Küçük, Canan Demirtaş, Murat Özdemir
BACKGROUND: Clinical and epidemiological data well defines the role of atherosclerotic risk factors in pathogenesis of aortic stenosis. Especially dyslipidemia with elevated total and LDL cholesterol levels exerts certain histopathological changes on calcified valve tissue. Exact role of HDL in this process is not known. OBJECTIVE: To evaluate the lipid profiles of patients with mild aortic valve stenosis with special focus on HDL; HDL subspecies, serum apoA1 levels, HDL related PON1 and PAF-AH enzyme activities and to correlate this with disease progression rates...
2015: International Journal of Clinical and Experimental Medicine
Yulan Ye, Zhi Pang, Weichang Chen, Songwen Ju, Chunli Zhou
This review aimed to summarize the epidemiology (incidence, prevalence and morality) and risk factors of inflammatory bowel disease (IBD). IBD is a chronic, relapsing, inflammatory disorder of the gastrointestinal tract and includes Crohn's Disease (CD) and ulcerative colitis (UC). IBD has increasing incidence and prevalence in most of countries and becomes a global emerging disease. A westernized lifestyle or habits and some environmental factors have been found to contribute to the pathogenesis of IBD. The relevant risk factors include Smoking, hygiene hypothesis, microorganisms, appendectomy, medication, nutrition, and stress have all been found to be associated with the modality of IBD, but results are inconsistent on this issue in available studies...
2015: International Journal of Clinical and Experimental Medicine
Yu Sun, Chenlei Shi, Tiefeng Shi, Jiangtao Yu, Zhaozhu Li
OBJECTIVE: To evaluate the relationship between BRAF mutation and factors influencing the prognosis of papillary thyroid microcarcinoma (PTMC). METHODS: Clinical data from patients with PTMC were subjected to retrospective analysis. A total of 86 patients were included, and the BRAF(V600E) mutation was identified in surgically dissected tissues. RESULTS: The incidence of BRAF mutation in patients with PTMC was 65.1% (56/86). Both univariate and multivariate analyses indicated a correlation between BRAF mutation and lymph node metastasis (P = 0...
2015: International Journal of Clinical and Experimental Medicine
Shi-Feng Long, Guo-An Chen, Mu-Shui Fang
PURPOSE: To explore the role of serum interleukin-16 (IL-16) in the occurrence of multiple myeloma (MM) and after the success chemotherapy and its clinical significance. METHODS: 52 cases of MM patients, 30 cases of AML patients and 30 healthy volunteers from Jan. 2011 to Jan. 2015 were collected in this study. There was 39 MM patients received chemotherapy. Among those, 24 patients received VAD regimen chemotherapy and 15 patients received BD regimen chemotherapy...
2015: International Journal of Clinical and Experimental Medicine
Gursel Gunes, Umit Yavuz Malkan, Hatime Arzu Yasar, Eylem Eliacik, Ibrahim Celalettin Haznedaroglu, Haluk Demiroglu, Nilgun Sayinalp, Salih Aksu, Sezgin Etgul, Tuncay Aslan, Hakan Goker, Osman Ilhami Ozcebe, Yahya Buyukasik
INTRODUCTION: Acquired erythroblastopenia (AE) is a rare clinical situation. It is characterized by the reduction of erythroid precursors in the bone marrow together with the low reticulocyte counts in the peripheral blood. BACKGROUND: Main secondary causes of AE are drugs, Parvovirus B19 and other infectious reasons, lymphoid and myeloid neoplasia, autoimmune diseases, thymoma and pregnancy. The aim of this study is to assess the frequencies and clinical associations of AE via analyzing 12340 bone marrow samples in a retrospective manner...
2015: International Journal of Clinical and Experimental Medicine
Chong Li, Xiaojuan Zheng, Michelle Ghert, Hai Li, Bin Wang, Yizhong Feng
BACKGROUND: Giant cell tumor of bone (GCTB) is a relatively rare tumor of bone, characterized by numerous multinucleated cells, severe osteolysis, and local recurrence. PURPOSE: To explore the role of S-phase kinase-interacting protein 2 (Skp2), cyclin-dependent kinase inhibitor p27, and the transcription factor E2F-1 expression in the development of GCTB, and the relationship of expression of these proteins with tumor recurrence. METHODS: Forty-four patients with GCTB were selected and demographic and clinical data were collected...
2015: International Journal of Clinical and Experimental Medicine
Shengjun Zhou, Jikuang Zhao, Zhepei Wang, Keqin Li, Sheng Nie, Feng Gao, Jie Sun, Xiang Gao, Yi Huang
We aimed to evaluate the association of rs964184 of BUD13-ZNF259 gene with the risk of hemorrhagic stroke (HS). A total of 138 HS cases and 587 controls were recruited for the association of rs964184 of BUD13-ZNF259 gene with the risk of HS. Tm shift PCR was used for genotyping. We were unable to find the association of rs964184 of BUD13-ZNF259 gene with the risk of HS (P>0.05). Significant difference was found in the TG level among the three genotypes (CC: 1.51±1.02; CG: 1.68±1.10; GG: 1.90±1.11, P=0...
2015: International Journal of Clinical and Experimental Medicine
De Zhou, Li Li, Changqian Bao, Jingjing Zhu, Lixia Zhu, Xiudi Yang, Yanlong Zheng, Meng Zhou, Xuxia Luo, Wanzhuo Xie, Xiujin Ye
Diffuse large B-cell lymphoma (DLBCL) is the most frequent type of non-Hodgkin's lymphoma (NHL) in adults, and approximately 50% of cases of DLBCL occur in patients above the age of 60. Although RCHOP regimen was established as the standard therapy for DLBCL patients, there are still a large number of DLBCL patients who can't bear the toxicity of doxorubicin, especially in elderly patients. Pegylated liposomal doxorubicin (PLD) offers a new strategy for elderly DLBCL patients. In our study, we reviewed 103 newly diagnosed patients with DLBCL aged between 60 years to 75 years old who were treated with RCHOP (62 cases) or DRCOP (41 cases) regimen...
2015: International Journal of Clinical and Experimental Medicine
Veysel Kidir, Atila Altuntas, Salih Inal, Abdullah Akpinar, Hikmet Orhan, Mehmet Tugrul Sezer
INTRODUCTION: Sexual dysfunction and vitamin D deficiency are highly prevalent in dialysis patients. Low levels of vitamin D have been linked to many diseases. To the best of our knowledge, the relationship between vitamin D and sexual dysfunction in dialysis patients has not been previously reported in the literature. MATERIALS AND METHODS: Cholecalciferol, 50,000 IU/week, was orally administered to 37 dialysis patients with vitamin D insufficiency for 3 months followed by dosage of 10,000 IU every other week for 3 months...
2015: International Journal of Clinical and Experimental Medicine
Biao Chen, Bin Li, Yong-Jian Qi, Kai Tie, Liao-Bin Chen
BACKGROUND: Anterior cruciate ligament (ACL) rupture is the most common ligamentous injury for active adolescents and young adults each year. However, the precise etiologies of ACL injury are not fully understood. The present study was to investigate +104T/C polymorphism of growth differentiation factor 5 (GDF5) gene in patients with ACL rupture, and evaluate the effects of polymorphism on GDF5 mRNA levels in ligament of patients with ACL rupture in central China. METHODS: A total of 286 Chinese patients with ACL rupture and 500healthy controls were enrolled in this study...
2015: International Journal of Clinical and Experimental Medicine
Violeta M Madrigal-Perez, Alejandro García-Rivera, Alejandrina Rodriguez-Hernandez, Gabriel Ceja-Espiritu, Xochitl G Briseño-Gomez, Hector R Galvan-Salazar, Alejandro D Soriano-Hernandez, Jose Guzman-Esquivel, Margarita L Martinez-Fierro, Oscar A Newton-Sanchez, Bertha A Olmedo Buenrostro, Iram P Rodriguez-Sanchez, Uriel A López-Lemus, Agustin Lara-Esqueda, Ivan Delgado-Enciso
Nonalcoholic steatohepatitis (NASH) is currently one of the primary liver diseases. Recent studies have shown a clinical relation between NASH and atherosclerosis. There is much interest in these two diseases because they are both associated with great morbidity and mortality. Inflammation and the overexpression of COX-2 participate in the pathophysiology of the two diseases, and therefore simultaneous treatment is feasible. The role of the four NSAIDs, meclofenamate, mefenamate, flufenamate, and aspirin, was analyzed in a mouse model of NASH, as well as preclinical atherosclerosis induced by a high-fat diet (HFD)...
2015: International Journal of Clinical and Experimental Medicine
Jingsheng Zhao, Xinwei Lin, Xueqing Xiao, Jun Yang, Hong Liu, Weiguo Yi, Zhengchen Zhang, Xinkuan Zhang
The Chronic kidney disease (CKD) is characterized by the progressive loss in renal function over a period. The progression of CKD will finally result the End Stage Renal Disease (ESRD) Symptoms which needs permanent renal replacement therapies. Therefore, control the progression of CKD is necessary. In this study, based on the theory of Traditional Chinese Medicine and the Traditional Chinese Herbology, we developed the Kangshen Oral Solution based ona combination of different herbs for extraction. By utilizing adriamycin (ARD)-induced chronic renal failure in rats as the CKD model, our results demonstrated thatadministration of the Kangshen Oral Solution reduced the kidney disease induced weight loss in rats...
2015: International Journal of Clinical and Experimental Medicine
Dan-Shu Liu, Feng Guan, Bin Wang, Tian Zhang
Postoperative pain is the main obstacle for safely rapid recovery of patients undergoing laparoscopic cholecystectomy (LC). In this study, we systemically evaluated the analgesic efficacy of intraperitoneal and incisional ropivacaine injected at the end of the LC. A total of 160 patients, scheduled for elective LC, were allocated into four groups. Group Sham received intraperitoneal and incisional normal saline (NS). Group IC received incisional ropivacaine and intraperitoneal NS. Group IP received incisional NS and intraperitoneal ropivacaine...
2015: International Journal of Clinical and Experimental Medicine
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