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Journal of Innate Immunity

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https://www.readbyqxmd.com/read/29439264/innate-immunity-of-the-lung-from-basic-mechanisms-to-translational-medicine
#1
Dominik Hartl, Rabindra Tirouvanziam, Julie Laval, Catherine M Greene, David Habiel, Lokesh Sharma, Ali Önder Yildirim, Charles S Dela Cruz, Cory M Hogaboam
The respiratory tract is faced daily with 10,000 L of inhaled air. While the majority of air contains harmless environmental components, the pulmonary immune system also has to cope with harmful microbial or sterile threats and react rapidly to protect the host at this intimate barrier zone. The airways are endowed with a broad armamentarium of cellular and humoral host defense mechanisms, most of which belong to the innate arm of the immune system. The complex interplay between resident and infiltrating immune cells and secreted innate immune proteins shapes the outcome of host-pathogen, host-allergen, and host-particle interactions within the mucosal airway compartment...
February 13, 2018: Journal of Innate Immunity
https://www.readbyqxmd.com/read/29393221/the-synergy-of-endotoxin-and-1%C3%A2-3-%C3%AE-d-glucan-from-gut-translocation-worsens-sepsis-severity-in-a-lupus-model-of-fc-gamma-receptor-iib-deficient-mice
#2
Jiraphorn Issara-Amphorn, Saowapha Surawut, Navaporn Worasilchai, Arthid Thim-Uam, Malcolm Finkelman, Ariya Chindamporn, Tanapat Palaga, Nattiya Hirankarn, Prapaporn Pisitkun, Asada Leelahavanichkul
We investigated the influence of spontaneous gut leakage upon polymicrobial sepsis in a lupus model with Fc gamma receptor IIb-deficient (FcGRIIb-/-) mice aged 8 and 40 weeks, as representing asymptomatic and symptomatic lupus, respectively. Spontaneous gut leakage, determined by (i) the presence of FITC-dextran, (ii) elevated serum endotoxin, and (iii) elevated serum (1→3)-β-D-glucan (BG), was demonstrated in symptomatic lupus but not in the asymptomatic group. In parallel, spontaneous gut leakage, detected by elevated serum BG without fungal infection, was demonstrated in patients with active lupus nephritis...
January 31, 2018: Journal of Innate Immunity
https://www.readbyqxmd.com/read/29393212/toll-interacting-protein-tollip-inhibits-il-13-mediated-pulmonary-eosinophilic-inflammation-in-mice
#3
Yoko Ito, Niccolette Schaefer, Amelia Sanchez, David Francisco, Rafeul Alam, Richard J Martin, Julie G Ledford, Connor Stevenson, Di Jiang, Liwu Li, Monica Kraft, Hong Wei Chu
Toll-interacting protein (Tollip) is a key negative regulator of innate immunity by preventing excessive proinflammatory responses. Tollip genetic variation has been associated with airflow limitation in asthma subjects and Tollip expression. Whether Tollip regulates lung inflammation in a type 2 cytokine milieu (e.g., IL-13) is unclear. Our goal was to determine the in vivo role of Tollip in IL-13-mediated lung eosinophilic inflammation and the underlying mechanisms. Tollip-knockout (KO) and wild-type (WT) mice were inoculated intranasally with recombinant mouse IL-13 protein to examine lung inflammation...
January 27, 2018: Journal of Innate Immunity
https://www.readbyqxmd.com/read/29334679/the-il20-genetic-polymorphism-is-associated-with-altered-clinical-outcome-in-septic-shock
#4
Taka-Aki Nakada, Petch Wacharasint, James A Russell, John H Boyd, Emiri Nakada, Simone A Thair, Tadanaga Shimada, Keith R Walley
BACKGROUND: The IL10 family of genes includes crucial immune regulators. We tested the hypothesis that single nucleotide polymorphisms (SNPs) in IL10, IL19, IL20, and IL24 of the IL10 family gene cluster alter the clinical outcome of septic shock. METHODS: Patients with septic shock (n = 1,193) were genotyped for 13 tag SNPs of IL10, IL19, IL20, and IL24. IL20 gene expression was measured in genotyped lymphoblastoid cells in vitro. Cardiac surgical ICU patients (n = 981) were genotyped for IL20 rs2981573 A/G...
January 16, 2018: Journal of Innate Immunity
https://www.readbyqxmd.com/read/29320784/going-fishing
#5
(no author information available yet)
No abstract text is available yet for this article.
January 11, 2018: Journal of Innate Immunity
https://www.readbyqxmd.com/read/29306950/immune-consequences-of-in-vitro-infection-of-human-peripheral-blood-leukocytes-with-vesicular-stomatitis-virus
#6
Tomasz Tomczyk, Grażyna Wróbel, Radosław Chaber, Iwona Siemieniec, Egbert Piasecki, Małgorzata Krzystek-Korpacka, Beata U Orzechowska
BACKGROUND: Oncolytic vesicular stomatitis virus (VSV) can be delivered intravenously to target primary and metastatic lesions, but the interaction between human peripheral blood leukocytes (PBLs) and VSV remains poorly understood. Our study aimed to assess the overall immunological consequences of ex vivo infection of PBLs with VSV. METHODS: Phenotypic analysis of lymphocyte subsets and apoptosis were evaluated with flow cytometry. Caspase 3/7 activity was detected by luminescence assay...
January 6, 2018: Journal of Innate Immunity
https://www.readbyqxmd.com/read/29248928/differential-kinetics-of-aspergillus-nidulans-and-aspergillus-fumigatus-phagocytosis
#7
Mark S Gresnigt, Katharina L Becker, Floris Leenders, M Fernanda Alonso, Xiaowen Wang, Jacques F Meis, Judith M Bain, Lars P Erwig, Frank L van de Veerdonk
Invasive aspergillosis mainly occurs in immunocompromised patients and is commonly caused by Aspergillus fumigatus, while A.nidulans is rarely the causative agent. However, in chronic granulomatous disease (CGD) patients, A. nidulans is a frequent cause of invasive aspergillosis and is associated with higher mortality. Immune recognition of A. nidulans was compared to A. fumigatus to offer an insight into why A. nidulans infections are prevalent in CGD. Live cell imaging with J774A.1 macrophage-like cells and LC3-GFP-mCherry bone marrow-derived macrophages (BMDMs) revealed that phagocytosis of A...
December 16, 2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/29237166/kallikrein-cleaves-c3-and-activates-complement
#8
Sarah Irmscher, Nadia Döring, Luke D Halder, Emeraldo A H Jo, Isabell Kopka, Christine Dunker, Ilse D Jacobsen, Shanshan Luo, Hortense Slevogt, Stefan Lorkowski, Niklas Beyersdorf, Peter F Zipfel, Christine Skerka
The human plasma contact system is an immune surveillance system activated by the negatively charged surfaces of bacteria and fungi and includes the kallikrein-kinin, the coagulation, and the fibrinolytic systems. Previous work shows that the contact system also activates complement, and that plasma enzymes like kallikrein, plasmin, thrombin, and FXII are involved in the activation process. Here, we show for the first time that kallikrein cleaves the central complement component C3 directly to yield active components C3b and C3a...
December 14, 2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/29212075/echinochrome-a-release-by-red-spherule-cells-is-an-iron-withholding-strategy-of-sea-urchin-innate-immunity
#9
Christopher J Coates, Claire McCulloch, Joshua Betts, Tim Whalley
Cellular immune defences in sea urchins are shared amongst the coelomocytes - a heterogeneous population of cells residing in the coelomic fluid (blood equivalent) and tissues. The most iconic coelomocyte morphotype is the red spherule cell (or amebocyte), so named due to the abundance of cytoplasmic vesicles containing the naphthoquinone pigment echinochrome A. Despite their identification over a century ago, and evidence of antiseptic properties, little progress has been made in characterising the immunocompetence of these cells...
December 7, 2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/29186718/interferon-stimulated-genes-as-enhancers-of-antiviral-innate-immune-signaling
#10
Keaton M Crosse, Ebony A Monson, Michael R Beard, Karla J Helbig
The ability of a host to curb a viral infection is heavily reliant on the effectiveness of an initial antiviral innate immune response, resulting in the upregulation of interferon (IFN) and, subsequently, IFN-stimulated genes (ISGs). ISGs serve to mount an antiviral state within a host cell, and although the specific antiviral function of a number of ISGs has been characterized, the function of many of these ISGs remains to be determined. Recent research has uncovered a novel role for a handful of ISGs, some of them directly induced by IFN regulatory factor 3 in the absence of IFN itself...
November 30, 2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/29176319/e3-ubiquitin-ligase-rnf125-activates-interleukin-36-receptor-signaling-and-contributes-to-its-turnover
#11
Siddhartha S Saha, Gary Caviness, Guanghui Yi, Ernest L Raymond, M Lamine Mbow, C Cheng Kao
Signaling by the interleukin-36 receptor (IL-36R) is linked to inflammatory diseases such as psoriasis. However, the regulation of IL-36R signaling is poorly understood. Activation of IL-36R signaling in cultured cells results in an increased polyubiquitination of the receptor subunit, IL-1Rrp2. Treatment with deubiquitinases shows that the receptor subunit of IL-36R, IL-1Rrp2, is primarily polyubiquitinated at the K63 position, which is associated with endocytic trafficking and signal transduction. A minor amount of ubiquitination is at the K48 position that is associated with protein degradation...
November 25, 2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/29393206/erratum
#12
(no author information available yet)
No abstract text is available yet for this article.
2018: Journal of Innate Immunity
https://www.readbyqxmd.com/read/29131106/gut-microbiota-dependent-modulation-of-energy-metabolism
#13
Christina N Heiss, Louise E Olofsson
The gut microbiota has emerged as an environmental factor that modulates the host's energy balance. It increases the host's ability to harvest energy from the digested food, and produces metabolites and microbial products such as short-chain fatty acids, secondary bile acids, and lipopolysaccharides. These metabolites and microbial products act as signaling molecules that modulate appetite, gut motility, energy uptake and storage, and energy expenditure. Several findings suggest that the gut microbiota can affect the development of obesity...
November 8, 2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/29069656/cyclosporine-a-induces-micrornas-controlling-innate-immunity-during-renal-bacterial-infection
#14
Malick Sadio, Emilie Tourneur, Marcelle Bens, Jean-Michel Goujon, Alain Vandewalle, Cécilia Chassin
Urinary tract infections (UTIs) mainly due to uropathogenic Escherichia coli (UPEC) are one of the most frequent complications in kidney-transplanted patients, causing significant morbidity. However, the mechanisms underlying UTI in renal grafts remain poorly understood. Here, we analysed the effects of the potent immunosuppressive agent cyclosporine A (CsA) on the activation of collecting duct cells that represent a preferential site of adhesion and translocation for UPEC. CsA induced the inhibition of lipopolysaccharide- induced activation of collecting duct cells due to the downregulation of the expression of TLR4 via the microRNA Let-7i...
October 26, 2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/29069650/dnajb1-hsp40-suppresses-melanoma-differentiation-associated-gene-5-mitochondrial-antiviral-signaling-protein-function-in-conjunction-with-hsp70
#15
Ken Takashima, Hiroyuki Oshiumi, Misako Matsumoto, Tsukasa Seya
Melanoma differentiation-associated gene 5 (MDA5) is a pattern recognition receptor that recognizes cytoplasmic viral double-stranded RNA (dsRNA) and initiates rapid innate antiviral responses. MDA5 forms a filament-like multimer along the dsRNA leading to oligomerization, which in turn activates the adaptor protein mitochondrial antiviral signaling protein (MAVS) to provide a signal platform for the induction of type I interferon (IFN) and proinflammatory cytokines. The conformational switch of MDA5 causes antiviral defense, but excessive activation of the MDA5-MAVS pathway may result in autoimmune diseases...
October 26, 2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/29035888/nitric-oxide-mediates-insect-cellular-immunity-via-phospholipase-a2-activation
#16
Md Sadekuzzaman, David Stanley, Yonggyun Kim
After infection or invasion is recognized, biochemical mediators act in signaling insect immune functions. These include biogenic amines, insect cytokines, eicosanoids, and nitric oxide (NO). Treating insects or isolated hemocyte populations with different mediators often leads to similar results. Separate treatments with an insect cytokine, 2 biogenic amines, and an eicosanoid lead to a single result, hemocyte spreading, understood in terms of intracellular cross-talk among these signaling systems. This study focuses on the cross-talk between NO and eicosanoid signaling in our model insect, Spodoptera exigua...
October 17, 2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/29035880/immunoregulation-of-neutrophil-extracellular-trap-formation-by-endothelial-derived-p33-gc1q-receptor
#17
Ariane Neumann, Praveen Papareddy, Johannes Westman, Ole Hyldegaard, Johanna Snäll, Anna Norrby-Teglund, Heiko Herwald
The formation of neutrophil extracellular traps (NETs) is a host defence mechanism, known to facilitate the entrapment and growth inhibition of many bacterial pathogens. It has been implicated that the translocation of myeloperoxidase (MPO) from neutrophilic granules to the nucleus is crucial to this process. Under disease conditions, however, excessive NET formation can trigger self-destructive complications by releasing pathologic levels of danger-associated molecular pattern molecules (DAMPs). To counteract such devastating immune reactions, the host has to rely on precautions that help circumvent these deleterious effects...
October 17, 2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/28988241/macrophage-extracellular-traps-a-scoping-review
#18
Ryan S Doster, Lisa M Rogers, Jennifer A Gaddy, David M Aronoff
Tissue macrophages are derived from either circulating blood monocytes that originate in the bone marrow, or embryonic precursors that establish residence in tissues and are maintained independent of bone marrow progenitors. Macrophages perform diverse functions including tissue repair, the maintenance of homeostasis, and immune regulation. Recent studies have demonstrated that macrophages produce extracellular traps (ETs). ETs are an immune response by which a cell undergoes "ETosis" to release net-like material, with strands composed of cellular DNA that is studded with histones and cellular proteins...
October 7, 2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/29131042/bystander-cells-taking-action
#19
(no author information available yet)
No abstract text is available yet for this article.
2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/28977785/innate-immunity-protein-tag7-induces-3-distinct-populations-of-cytotoxic-cells-that-use-different-mechanisms-to-exhibit-their-antitumor-activity-on-human-leukocyte-antigen-deficient-cancer-cells
#20
Tatiana N Sharapova, Olga K Ivanova, Natalia V Soshnikova, Elena A Romanova, Lidia P Sashchenko, Denis V Yashin
The search for new immune response mechanisms capable of controlling immune-evasive tumor cells devoid of the MHC antigen is a challenging task for immunologists. In this study, we found that the treatment of human peripheral blood lymphocytes with the innate immunity protein Tag7 (PGRP-S, PGLYRP1) induces differentiation of the populations of NK (natural killer) cells and CD8+ and CD4+ T lymphocytes that are cytotoxic for human leukocyte antigen-negative tumor cells. These populations employ different mechanisms of tumor cell lysis (based on the release of granzymes in the case of NK cells and on the FasL-Fas interaction in the case of CD8+ and CD4+ T lymphocytes) and induce different death pathways (apoptosis or necroptosis) in tumor cells...
2017: Journal of Innate Immunity
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