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Cell Adhesion & Migration

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https://www.readbyqxmd.com/read/28640659/phlda1-pleckstrin-homology-like-domain-family-a-member-1-knockdown-promotes-migration-and-invasion-of-mcf10a-breast-epithelial-cells
#1
Naieli Bonatto, Maria José Carlini, Simone Aparecida de Bessa Garcia, Maria Aparecida Nagai
PHLDA1 (pleckstrin homology-like domain, family A, member 1) is a multifunctional protein that plays distinct roles in several biological processes including cell death and therefore its altered expression has been identified in different types of cancer. Progressively loss of PHLDA1 was found in primary and metastatic melanoma while its overexpression was reported in intestinal and pancreatic tumors. Previous work from our group showed that negative expression of PHLDA1 protein was a strong predictor of poor prognosis for breast cancer disease...
June 22, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28636424/fluid-shear-stress-regulates-hepg2-cell-migration-though-time-dependent-integrin-signaling-cascade
#2
Hongchi Yu, Yang Shen, Jingsi Jin, Yingying Zhang, Tang Feng, Xiaoheng Liu
Hepatocellular carcinoma (HCC) is a subtype of malignant liver cancer with poor prognosis and limited treatment options. It is noteworthy that mechanical forces in tumor microenvironment play a pivotal role in mediating the behaviors and functions of tumor cells. As an instrumental type of mechanical forces in vivo, fluid shear stress (FSS) has been reported having potent physiologic and pathologic effects on cancer progression. However, the time-dependent mechanochemical transduction in HCC induced by FSS remains unclear...
June 21, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28562165/her-2-epstein-barr-virus-crosstalk-in-human-gastric-carcinogenesis-a-novel-concept-of-oncogene-oncovirus-interaction
#3
Farhan S Cyprian, Noor Al-Antary, Ala-Eddin Al Moustafa
Gastric cancer is the fourth most common cancer and the second leading cause of cancer deaths worldwide. Additionally, it is well-known that metastatic cancer disease is a major cause of morbidity and mortality in cancer patients. Several investigations reported that HER-2 (ErbB-2 receptor) and Epstein-Barr virus (EBV) are important aetiological factors in human gastric cancer, where either oncogene/oncovirus alone can derive a major event of cancer progression and metastasis via epithelial-mesenchymal transition (EMT)...
May 31, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28524745/actin-cytoskeleton-regulates-functional-anchorage-migration-switch-during-t-cadherin-induced-phenotype-modulation-of-vascular-smooth-muscle-cells
#4
Agne Frismantiene, Emmanouil Kyriakakis, Boris Dasen, Paul Erne, Therese J Resink, Maria Philippova
Vascular smooth muscle cell (SMC) switching between differentiated and dedifferentiated phenotypes is reversible and accompanied by morphological and functional alterations that require reconfiguration of cell-cell and cell-matrix adhesion networks. Studies attempting to explore changes in overall composition of the adhesion nexus during SMC phenotype transition are lacking. We have previously demonstrated that T-cadherin knockdown enforces SMC differentiation, whereas T-cadherin upregulation promotes SMC dedifferentiation...
May 19, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28498731/tissue-transglutaminase-expression-is-necessary-for-adhesion-metastatic-potential-and-cancer-stemness-of-renal-cell-carcinoma
#5
Yesim Bagatur, Ayca Zeynep Ilter Akulke, Ajna Bihorac, Merve Erdem, Dilek Telci
Tissue transglutaminase (TG2) is the ubiquitously expressed member of transglutaminase family and shown to play a critical role in the development and progression of drug resistance malignancies. We have previously showed the association of TG2 upregulation with progression and metastasis of renal cell carcinoma (RCC) and low disease-free survival. In the present study we further investigate the role of TG2 in cell adhesion, migration and invasion of RCC by silencing TG2 expression in Caki-2 and A-498 primary site and Caki-1 and ACHN metastatic site RCC cell lines...
May 12, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28494186/small-interference-itga6-gene-targeting-in-the-human-thymic-epithelium-differentially-regulates-the-expression-of-immunological-synapse-related-genes
#6
Daiane Cristina F Golbert, Eliane Santana-Van-Vliet, Marcelo Ribeiro-Alves, Marbella Maria B da Fonsêca, Ailin Lepletier, Daniella Arêas Mendes-da-Cruz, Guilherme Loss, Vinícius Cotta-de-Almeida, Ana Tereza R Vasconcelos, Wilson Savino
The thymus supports differentiation of T cell precursors. This process requires relocation of developing thymocytes throughout multiple microenvironments of the organ, mainly with thymic epithelial cells (TEC), which control intrathymic T cell differentiation influencing the formation and maintenance of the immunological synapse. In addition to the proteins of the major histocompatibility complex (MHC), this structure is supported by several adhesion molecules. During the process of thymopoiesis, we previously showed that laminin-mediated interactions are involved in the entrance of T-cell precursors into the thymus, as well as migration of differentiating thymocytes within the organ...
May 11, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28471324/the-structure-function-relationships-of-insulin-like-growth-factor-1-ec-in-c2c12-cells
#7
Qian Yi, Jianguo Feng, Ling He, Rongxue Wan, Hui Zeng, Li Yang, Shiyong Wu, Liling Tang
Insulin-like growth factor 1 (IGF1) is a crucial growth factor, that regulates skeletal muscles development during cell growth and repair. Recently, its alternative splicing variant, named IGF1Ec, also named mechano-growth factor (MGF), has gained attentions as a new damage repair factor. However, the structure-function relationships of IGF1Ec have not been fully clarified due to contradictory reports. In this study, we systematically investigated physiologic responses of C2C12 muscle cells to IGF1Ec, IGF1 and MGF E peptide...
May 4, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28430001/annexins-in-cell-migration-and-adhesion
#8
Thomas Grewal
No abstract text is available yet for this article.
May 4, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28060564/annexin-a8-promotes-vegf-a-driven-endothelial-cell-sprouting
#9
Nicole Heitzig, Benjamin F Brinkmann, Sophia N Koerdt, Gonzalo Rosso, Victor Shahin, Ursula Rescher
The physiological and pathological process of angiogenesis relies on orchestrated endothelial cell (EC) adhesion, migration and formation of new vessels. Here we report that human umbilical vein endothelial cells (HUVECs) deficient in Annexin A8 (AnxA8), a member of the annexin family of Ca(2+)- and membrane binding proteins, are strongly deficient in their ability to sprout in response to vascular endothelial growth factor (VEGF)-A, and are strongly impaired in their ability to migrate and adhere to β1 integrin-binding extracellular matrix (ECM) proteins...
May 4, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28060548/annexin-a6-a-multifunctional-scaffold-in-cell-motility
#10
Thomas Grewal, Monira Hoque, James R W Conway, Meritxell Reverter, Mohamed Wahba, Syed S Beevi, Paul Timpson, Carlos Enrich, Carles Rentero
Annexin A6 (AnxA6) belongs to a highly conserved protein family characterized by their calcium (Ca(2+))-dependent binding to phospholipids. Over the years, immunohistochemistry, subcellular fractionations, and live cell microscopy established that AnxA6 is predominantly found at the plasma membrane and endosomal compartments. In these locations, AnxA6 acts as a multifunctional scaffold protein, recruiting signaling proteins, modulating cholesterol and membrane transport and influencing actin dynamics. These activities enable AnxA6 to contribute to the formation of multifactorial protein complexes and membrane domains relevant in signal transduction, cholesterol homeostasis and endo-/exocytic membrane transport...
May 4, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/27860536/the-advantageous-role-of-annexin-a1-in-cardiovascular-disease
#11
Renske de Jong, Giovanna Leoni, Maik Drechsler, Oliver Soehnlein
The inflammatory response protects the human body against infection and injury. However, uncontrolled and unresolved inflammation can lead to tissue damage and chronic inflammatory diseases. Therefore, active resolution of inflammation is essential to restore tissue homeostasis. This review focuses on the pro-resolving molecule annexin A1 (ANXA1) and its derived peptides. Mechanisms instructed by ANXA1 are multidisciplinary and affect leukocytes as well as endothelial cells and tissue resident cells like macrophages and mast cells...
May 4, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/27834582/hypoxia-regulates-anxa1-expression-to-support-prostate-cancer-cell-invasion-and-aggressiveness
#12
Valentina Bizzarro, Raffaella Belvedere, Vincenzo Migliaro, Elena Romano, Luca Parente, Antonello Petrella
Annexin A1 (ANXA1) is a Ca(2+)-binding protein overexpressed in the invasive stages of prostate cancer (PCa) development; however, its role in this tumor metastatization is largely unknown. Moreover, hypoxic conditions in solid tumors have been related to poor prognosis in PCa patients. We have previously demonstrated that ANXA1 is implicated in the acquisition of chemo-resistant features in DU145 PCa cells conferring them a mesenchymal/metastatic phenotype. In this study, we have investigated the mechanisms by which ANXA1 regulates metastatic behavior in LNCaP, DU145 and PC3 cells exposed to hypoxia...
May 4, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/27322022/role-of-the-p55-gamma-subunit-of-pi3k-in-alk-induced-cell-migration-rnai-based-selection-of-cell-migration-regulators
#13
Minchul Seo, Jong-Heon Kim, Kyoungho Suk
Recently, unbiased functional genetic selection identified novel cell migration-regulating genes. This RNAi-based functional selection was performed using 63,996 pooled lentiviral shRNAs targeting 21,332 mouse genes. After five rounds of selection using cells with accelerated or impaired migration, shRNAs were retrieved and identified by half-hairpin barcode sequencing using cells with the selected phenotypes. This selection process led to the identification of 29 novel cell migration regulators. One of these candidates, anaplastic lymphoma kinase (ALK), was further investigated...
May 4, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/27314915/study-of-the-involvement-of-allogeneic-mscs-in-bone-formation-using-the-model-of-transgenic-mice
#14
Daria Kuznetsova, Natalia Prodanets, Svetlana Rodimova, Evgeny Antonov, Aleksandra Meleshina, Peter Timashev, Elena Zagaynova
Mesenchymal stem cells (MSCs) are thought to be the most attractive type of cells for bone repair. However, much still remains unknown about MSCs and needs to be clarified before this treatment can be widely applied in the clinical practice. The purpose of this study was to establish the involvement of allogeneic MSCs in the bone formation in vivo, using a model of transgenic mice and genetically labeled cells. Polylactide scaffolds with hydroxyapatite obtained by surface selective laser sintering were used...
May 4, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/27254775/desmoglein-3-regulates-membrane-trafficking-of-cadherins-an-implication-in-cell-cell-adhesion
#15
Hanan Moftah, Kasuni Dias, Ehsanul Hoque Apu, Li Liu, Jutamas Uttagomol, Lesley Bergmeier, Stephanie Kermorgant, Hong Wan
E-cadherin mediated cell-cell adhesion plays a critical role in epithelial cell polarization and morphogenesis. Our recent studies suggest that the desmosomal cadherin, desmoglein 3 (Dsg3) cross talks with E-cadherin and regulates its adhesive function in differentiating keratinocytes. However, the underlying mechanism remains not fully elucidated. Since E-cadherin trafficking has been recognized to be a central determinant in cell-cell adhesion and homeostasis we hypothesize that Dsg3 may play a role in regulating E-cadherin trafficking and hence the cell-cell adhesion...
May 4, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28346043/structural-abnormalities-in-the-primary-somatosensory-cortex-and-a-normal-behavioral-profile-in-contactin-5-deficient-mice
#16
Kristel T E Kleijer, Denise van Nieuwenhuize, Henk A Spierenburg, Sara Gregorio-Jordan, Martien J H Kas, J Peter H Burbach
Contactin-5 (Cntn5) is an immunoglobulin cell adhesion molecule that is exclusively expressed in the central nervous system. In view of its association with neurodevelopmental disorders, particularly autism spectrum disorder (ASD), this study focused on Cntn5-positive areas in the forebrain and aimed to explore the morphological and behavioral phenotypes of the Cntn5 null mutant (Cntn5(-/-)) mouse in relation to these areas and ASD symptomatology. A newly generated antibody enabled us to elaborately describe the spatial expression pattern of Cntn5 in P7 wild type (Cntn5(+/+)) mice...
March 27, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28328292/il-6-is-involved-in-malignancy-and-doxorubicin-sensitivity-of-renal-carcinoma-cells
#17
Yanqiang Chen, Jianzhen Liu, Pei Lv, Jiangyan Gao, Mingzheng Wang, Yongjun Wang
Various survival factors such as the pleiotropic cytokine interleukin-6 (IL-6), a major mediator of inflammation and activator of signal transducer and activator of transcription 3 (STAT3), serve to block apoptosis in cancer cells. Our present study revealed that the expression of IL-6, while not other IL-2, IL-4, IL-8, or IL-10, was significantly elevated in resistance of renal carcinoma cells (RCC) when compared with human renal proximal tubule epithelial cell line HK-2. The inhibition of IL-6 by siRNA can suppress the proliferation, migration and invasion of RCC cells and increase the doxorubicin (Dox) sensitivity...
March 22, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28166442/exosomes-in-cancer-theranostic-diamonds-in-the-rough
#18
Marine Cordonnier, Gaëtan Chanteloup, Nicolas Isambert, Renaud Seigneuric, Pierre Fumoleau, Carmen Garrido, Jessica Gobbo
During the last 10 years, exosomes, which are small vesicles of 50-200 nm diameter of endosomal origin, have aroused a great interest in the scientific and clinical community for their roles in intercellular communication in almost all physiological and pathological processes. Most cells can potentially release these nanovesicles that share with the parent cell a similar lipid bilayer with transmembrane proteins and a panel of enclosed soluble proteins such as heat shock proteins and genetic material, thus acting as potential nanoshuttles of biomarkers...
March 4, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28165857/extracellular-vesicles-on-the-wire
#19
Vincent Hyenne, Jacky G Goetz
No abstract text is available yet for this article.
March 4, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28146372/the-isolation-of-morphologically-intact-and-biologically-active-extracellular-vesicles-from-the-secretome-of-cancer-associated-adipose-tissue
#20
Sarah Jeurissen, Glenn Vergauwen, Jan Van Deun, Lore Lapeire, Victoria Depoorter, Ilkka Miinalainen, Raija Sormunen, Rudy Van den Broecke, Geert Braems, Véronique Cocquyt, Hannelore Denys, An Hendrix
Breast cancer cells closely interact with different cell types of the surrounding adipose tissue to favor invasive growth and metastasis. Extracellular vesicles (EVs) are nanometer-sized vesicles secreted by different cell types that shuttle proteins and nucleic acids to establish cell-cell communication. To study the role of EVs released by cancer-associated adipose tissue in breast cancer progression and metastasis a standardized EV isolation protocol that obtains pure EVs and maintains their functional characteristics is required...
March 4, 2017: Cell Adhesion & Migration
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