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Cell Adhesion & Migration

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https://www.readbyqxmd.com/read/28166442/exosomes-in-cancer-theranostic-diamonds-in-the-rough
#1
Marine Cordonnier, Gaëtan Chanteloup, Nicolas Isambert, Renaud Seigneuric, Pierre Fumoleau, Carmen Garrido, Jessica Gobbo
During the last 10 years, exosomes, which are small vesicles of 50-200 nm diameter of endosomal origin, have aroused a great interest in the scientific and clinical community for their roles in intercellular communication in almost all physiological and pathological processes. Most cells can potentially release these nanovesicles that share with the parent cell a similar lipid bilayer with transmembrane proteins and a panel of enclosed soluble proteins such as heat shock proteins and genetic material, thus acting as potential nanoshuttles of biomarkers...
February 6, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28165857/extracellular-vesicles-on-the-wire
#2
Vincent Hyenne, Jacky G Goetz
No abstract text is available yet for this article.
February 6, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28152318/hedgehog-signaling-stimulates-tenascin-c-to-promote-invasion-of-pancreatic-ductal-adenocarcinoma-cells-through-annexin-a2
#3
Kelly Foley, Stephen Muth, Elizabeth Jaffee, Lei Zheng
Pancreatic adenocarcinoma (PDA) is characterized by a dense desmoplastic reaction that comprises 60-90% of the tumor, while only 10-40% of the tumor is composed of malignant epithelial cells. This desmoplastic reaction is composed of stromal fibroblast cells, extracellular matrix proteins, and immune cells. Accumulating evidence has suggested that the stromal and epithelial cell compartments interact during the pathogenesis of this disease. Therefore, it is important to identify the signaling pathways responsible for this interaction to better understand the mechanisms by which PDA invades and metastasizes...
February 2, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28146373/osthole-inhibited-tgf-%C3%AE-induced-epithelial-mesenchymal-transition-emt-by-suppressing-nf-%C3%AE%C2%BAb-mediated-snail-activation-in-lung-cancer-a549-cells
#4
Haitao Feng, Jin-Jian Lu, Yitao Wang, Lixia Pei, Xiuping Chen
Epithelial-mesenchymal transition (EMT), the transdifferentiation of epithelial cells into mesenchymal cells, has been implicated in the metastasis and provides novel strategies for cancer therapy. Osthole (OST), a dominant active constituent of Chinese herb Cnidium monnieri, has been reported to inhibit cancer metastasis while the mechanisms remains unclear. Here, we studied the inhibitory effect and mechanisms of OST on TGF-β1-induced EMT in A549 cells. Cells were treated with TGF-β1 in the absence and presence of OST...
February 1, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28146372/the-isolation-of-morphologically-intact-and-biologically-active-extracellular-vesicles-from-the-secretome-of-cancer-associated-adipose-tissue
#5
Sarah Jeurissen, Glenn Vergauwen, Jan Van Deun, Lore Lapeire, Victoria Depoorter, Ilkka Miinalainen, Raija Sormunen, Rudy Van den Broecke, Geert Braems, Véronique Cocquyt, Hannelore Denys, An Hendrix
Breast cancer cells closely interact with different cell types of the surrounding adipose tissue to favor invasive growth and metastasis. Extracellular vesicles (EVs) are nanometer-sized vesicles secreted by different cell types that shuttle proteins and nucleic acids to establish cell-cell communication. To study the role of EVs released by cancer-associated adipose tissue in breast cancer progression and metastasis a standardized EV isolation protocol that obtains pure EVs and maintains their functional characteristics is required...
February 1, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28135898/going-live-with-tumor-exosomes-and-microvesicles
#6
Vincent Hyenne, Olivier Lefebvre, Jacky G Goetz
Tumor extracellular vesicles (EVs), including exosomes, emerged as key drivers of the pro-tumorigenic dialog between the tumor mass and its microenvironment by mediating long and short distance communication. In vitro studies defined the capacity of tumor EVs to modify the phenotypes of stromal and tumor cells. These studies are now supported by a growing number of functional in vivo experiments. Remarkably, they allowed the identification of a new role for tumor EVs in priming the pre-metastatic niches (PMN)...
January 31, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28135886/contactin-2-tag-1-active-on-the-front-line-for-three-decades
#7
Tomoyuki Masuda
Contactin-2/transiently expressed axonal surface glycoprotein-1 (TAG-1) is a cell adhesion molecule belonging to the immunoglobulin superfamily (IgSF). It has six immunoglobulin-like extracellular domains and four fibronectin III-like ones, with anchoring to the cell membrane through glycosylphosphatidyl inositol. Contactin-2/TAG-1 is expressed in specific neurons transiently on the axonal surface during the fetal period. In postnatal stages, Contactin-2/TAG-1 is expressed in cerebellar granule cells, hippocampal pyramidal cells, and the juxtaparanodal regions of myelinated nerve fibers...
January 31, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28129019/biochemical-analysis-of-force-sensitive-responses-using-a-large-scale-cell-stretch-device
#8
Derrick J Renner, Makena L Ewald, Timothy Kim, Soichiro Yamada
Physical force has emerged as a key regulator of tissue homeostasis, and plays an important role in embryogenesis, tissue regeneration, and disease progression. Currently, the details of protein interactions under elevated physical stress are largely missing, therefore, preventing the fundamental, molecular understanding of mechano-transduction. This is in part due to the difficulty isolating large quantities of cell lysates exposed to force-bearing conditions for biochemical analysis. We designed a simple, easy-to-fabricate, large-scale cell stretch device for the analysis of force-sensitive cell responses...
January 27, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28129015/exosome-secretion-promotes-chemotaxis-of-cancer-cells
#9
Bong Hwan Sung, Alissa M Weaver
Migration of cells toward chemical cues, or chemotaxis, is important for many biologic processes such as immune defense, wound healing and cancer metastasis. Although chemotaxis is thought to occur in cancer cells, it is less well characterized than chemotaxis of professional immune cells such as neutrophils. Here, we show that cancer cell chemotaxis relies on secretion of exosome-type extracellular vesicles. Migration of fibrosarcoma cells toward a gradient of exosome-depleted serum was diminished by knockdown of the exosome secretion regulator Rab27a...
January 27, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28060564/annexin-a8-promotes-vegf-a-driven-endothelial-cell-sprouting
#10
Nicole Heitzig, Benjamin F Brinkmann, Sophia N Koerdt, Gonzalo Rosso, Victor Shahin, Ursula Rescher
The physiological and pathological process of angiogenesis relies on orchestrated endothelial cell (EC) adhesion, migration and formation of new vessels. Here we report that human umbilical vein endothelial cells (HUVECs) deficient in Annexin A8 (AnxA8), a member of the annexin family of Ca(2+)- and membrane binding proteins, are strongly deficient in their ability to sprout in response to vascular endothelial growth factor (VEGF)-A, and are strongly impaired in their ability to migrate and adhere to β1 integrin-binding extracellular matrix (ECM) proteins...
January 6, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28060548/annexin-a6-a-multifunctional-scaffold-in-cell-motility
#11
Thomas Grewal, Monira Hoque, James R W Conway, Meritxell Reverter, Mohamed Wahba, Syed S Beevi, Paul Timpson, Carlos Enrich, Carles Rentero
Annexin A6 (AnxA6) belongs to a highly conserved protein family characterized by their calcium (Ca(2+)) -dependent binding to phospholipids. Over the years, immunohistochemistry, subcellular fractionations, and live cell microscopy established that AnxA6 is predominantly found at the plasma membrane and endosomal compartments. In these locations, AnxA6 acts as a multifunctional scaffold protein, recruiting signaling proteins, modulating cholesterol and membrane transport and influencing actin dynamics. These activities enable AnxA6 to contribute to the formation of multifactorial protein complexes and membrane domains relevant in signal transduction, cholesterol homeostasis and endo-/exocytic membrane transport...
January 6, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28059594/annexin-a6-a-multifunctional-scaffold-in-cell-motility
#12
Thomas Grewal, Monira Hoque, James R W Conway, Meritxell Reverter, Mohamed Wahba, Syed S Beevi, Paul Timpson, Carlos Enrich, Carles Rentero
Annexin A6 (AnxA6) belongs to a highly conserved protein family characterized by their calcium (Ca(2+)) -dependent binding to phospholipids. Over the years, immunohistochemistry, subcellular fractionations, and live cell microscopy established that AnxA6 is predominantly found at the plasma membrane and endosomal compartments. In these locations, AnxA6 acts as a multifunctional scaffold protein, recruiting signaling proteins, modulating cholesterol and membrane transport and influencing actin dynamics. These activities enable AnxA6 to contribute to the formation of multifactorial protein complexes and membrane domains relevant in signal transduction, cholesterol homeostasis and endo-/exocytic membrane transport...
January 6, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/27924678/a-novel-role-for-14-kda-phosphohistidine-phosphatase-in-lamellipodia-formation
#13
Anjian Xu, Xiaojin Li, Siwen Li, Lan Sun, Shanna Wu, Bei Zhang, Jian Huang
Cell migration involves dynamic regulation of the actin cytoskeleton, which exhibits rapid actin polymerization at the leading edge of migrating cells. This process relies on regulated recruitment of actin nucleators and actin-binding proteins to the leading edge to polymerize new actin filaments. Many of these proteins have been identified, including the actin-related protein (Arp) 2/3 complex, which has emerged as the core player in the initiation of actin polymerization. However, the functional coordination of these proteins is unclear...
December 7, 2016: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/27294313/two-complementary-strategies-to-improve-cell-engraftment-in-mesenchymal-stem-cell-based-therapy-increasing-transplanted-cell-resistance-and-increasing-tissue-receptivity
#14
Fernando E Ezquer, Marcelo E Ezquer, Jose M Vicencio, Sebastián D Calligaris
Over the past 2 decades, therapies based on mesenchymal stem cells (MSC) have been tested to treat several types of diseases in clinical studies, due to their potential for tissue repair and regeneration. Currently, MSC-based therapy is considered a biologically safe procedure, with the therapeutic results being very promising. However, the benefits of these therapies are not stable in the long term, and the final outcomes manifest with high inter-patient variability. The major cause of these therapeutic limitations results from the poor engraftment of the transplanted cells...
January 2, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/27224546/rac-gtpase-regulation-of-3d-invasion-in-neuroblastomas-lacking-mycn-amplification
#15
Camilla B Mitchell, Geraldine M O'Neill
Neuroblastomas are highly invasive tumors that occur in pediatric patients and treatment of invasive disease remains a challenge. The study of cells invading in 3-dimensional (3D) hydrogels has revealed morphologically distinct modes of invasion by which cancer cells adapt to the local tissue environment in order to invade local tissue. Specifically, the small G protein Rac GTPase has been implicated as regulating the elongated/mesenchymal mode of cell invasion. In the present study we demonstrate an inverse association between Rac expression and amplification of MYCN, a well-established prognostic indicator in neuroblastoma...
January 2, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/27196129/non-pungent-long-chain-capsaicin-analogs-arvanil-and-olvanil-display-better-anti-invasive-activity-than-capsaicin-in-human-small-cell-lung-cancers
#16
John D Hurley, Austin T Akers, Jamie R Friedman, Nicholas A Nolan, Kathleen C Brown, Piyali Dasgupta
The nutritional compound capsaicin inhibits the invasion of many types of human cancers. The clinical development of capsaicin as an anti-cancer drug is limited due to its unfavorable side effects like burning sensation, stomach cramps, gut pain and nausea. This study compared the anti-invasive activity of capsaicin to non-pungent long chain capsaicin analogs, namely arvanil and olvanil, in human small cell lung cancer cells. Boyden chamber invasion assays revealed that arvanil and olvanil displayed improved anti-invasive activity relative to capsaicin in human SCLC cells...
January 2, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/27159116/wnt5a-ryk-signaling-critically-affects-barrier-function-in-human-vascular-endothelial-cells
#17
Tom Skaria, Esther Bachli, Gabriele Schoedon
Satisfactory therapeutic strategies for septic shock are still missing. Previously we found elevated levels of Wnt5A in patients with severe sepsis and septic shock. Wnt5A is released by activated macrophages but knowledge of its effects in the vascular system remains scant. Here we investigate the response of human coronary artery endothelial cells (HCAEC) to Wnt5A. We used a genome-wide differential expression approach to define novel targets regulated by Wnt5A. Gene ontology analysis of expression profiles revealed clusters of genes involved in actin cytoskeleton remodeling as the predominant targets of Wnt5A...
January 2, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/27149140/the-influence-of-biomechanical-properties-and-cannabinoids-on-tumor-invasion
#18
Tim Hohmann, Urszula Grabiec, Chalid Ghadban, Kerstin Feese, Faramarz Dehghani
BACKGROUND: Cannabinoids are known to have an anti-tumorous effect, but the underlying mechanisms are only sparsely understood. Mechanical characteristics of tumor cells represent a promising marker to distinguish between tumor cells and the healthy tissue. We tested the hypothesis whether cannabinoids influence the tumor cell specific mechanical and migratory properties and if these factors are a prognostic marker for the invasiveness of tumor cells. METHODS: 3 different glioblastoma cell lines were treated with cannabinoids and changes of mechanical and migratory properties of single cells were measured using atomic force microscopy and time lapse imaging...
January 2, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/27111836/probing-cytoskeletal-pre-stress-and-nuclear-mechanics-in-endothelial-cells-with-spatiotemporally-controlled-de-adhesion-kinetics-on-micropatterned-substrates
#19
Marie Versaevel, Maryam Riaz, Tobias Corne, Thomas Grevesse, Joséphine Lantoine, Danahe Mohammed, Céline Bruyère, Laura Alaimo, Winnok H De Vos, Sylvain Gabriele
The mechanical properties of living cells reflect their propensity to migrate and respond to external forces. Both cellular and nuclear stiffnesses are strongly influenced by the rigidity of the extracellular matrix (ECM) through reorganization of the cyto- and nucleoskeletal protein connections. Changes in this architectural continuum affect cell mechanics and underlie many pathological conditions. In this context, an accurate and combined quantification of the mechanical properties of both cells and nuclei can contribute to a better understanding of cellular (dys-)function...
January 2, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/27111714/prostate-cancer-cells-specifically-reorganize-epithelial-cell-fibroblast-communication-through-proteoglycan-and-junction-pathways
#20
Anastasia V Suhovskih, Vladimir I Kashuba, George Klein, Elvira V Grigorieva
Microenvironment and stromal fibroblasts are able to inhibit tumor cell proliferation both through secreted signaling molecules and direct cell-cell interactions but molecular mechanisms of these effects remain unclear. In this study, we investigated a role of cell-cell contact-related molecules (protein ECM components, proteoglycans (PGs) and junction-related molecules) in intercellular communications between the human TERT immortalized fibroblasts (BjTERT fibroblasts) and normal (PNT2) or cancer (LNCaP, PC3, DU145) prostate epithelial cells...
January 2, 2017: Cell Adhesion & Migration
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