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Obesity Facts

Carel le Roux, Vanita Aroda, Joanna Hemmingsson, Ana Paula Cancino, Rune Christensen, Xavier Pi-Sunyer
OBJECTIVE: To investigate whether the efficacy and safety of liraglutide 3.0 mg differed between two subgroups, BMI 27 to <35 and BMI ≥ 35 kg/m², in individuals without and with type 2 diabetes (T2D). METHODS: A post-hoc analysis of two 56-week, randomized, double-blind, placebo-controlled trials (SCALE Obesity and Prediabetes; SCALE Diabetes). Subgroup differences in treatment effects of liraglutide 3.0 mg were evaluated by testing the interaction between treatment group and baseline BMI subgroup...
November 17, 2017: Obesity Facts
Gabriel Torbahn, Ines Gellhaus, Benjamin Koch, Rüdiger von Kries, Viola Obermeier, Reinhard W Holl, Katharina Fink, Andreas van Egmond-Fröhlich
OBJECTIVE: Treatment of paediatric obesity focuses on changes of nutrition and eating behaviour and physical activity. The evaluation of the patient education programme by KgAS was utilised to analyse the association of changes of portion size, eating rate and dietary habits with BMI-SDS reductions. METHODS: Patients (n = 297) were examined at the beginning and at the end of treatment and after 1-year follow-up at different out-patient centres. Their parents completed questionnaires including estimation of children's portion size, eating rate and frequency of food intake...
October 31, 2017: Obesity Facts
Jakob Kjellberg, Arendse Tange Larsen, Rikke Ibsen, Betina Højgaard
OBJECTIVE: To evaluate the socioeconomic impact of obesity by estimating the direct and indirect costs associated with obesity in Denmark, based on individual level data. METHODS: Costs were assessed for different BMI groups, and the relative risks for change in direct and indirect costs per BMI point above 30 were estimated. A fourth analysis estimated the odds ratio for comorbidities per BMI point above 30. Individual data on income, social transfer payments, healthcare costs and diagnoses were retrieved from national registries...
October 12, 2017: Obesity Facts
Deborah R Leitner, Gema Frühbeck, Volkan Yumuk, Karin Schindler, Dragan Micic, Euan Woodward, Hermann Toplak
Obesity is a chronic metabolic disease affecting adults and children worldwide. It has become one of the leading causes of death, as obesity is known to be the main risk factor for a number of non-communicable diseases, in particular type 2 diabetes. This close relationship led to the connotation 'diabesity', highlighting the fact that the majority of individuals with diabetes are overweight or obese. Until today the BMI is still used to classify overweight and obesity. Since reduced muscle mass is highly prevalent throughout the BMI range, the measurement of body composition is strongly recommended...
October 12, 2017: Obesity Facts
Johanne Aviaja Rosing, Karen Christina Walker, Benjamin A H Jensen, Berit L Heitmann
BACKGROUND: Recent studies have shown an association between weight change and the makeup of the intestinal microbiota in humans. Specifically, Lactobacillus, a part of the entire gastrointestinal tract's microbiota, has been shown to contribute to weight regulation. AIM: We examined the association between the level of oral Lactobacillus and the subsequent 6-year weight change in a healthy population of 322 Danish adults aged 35-65 years at baseline. DESIGN: Prospective observational study...
October 12, 2017: Obesity Facts
Károly Nagy, Szilvia Fiatal, János Sándor, Róza Ádány
AIMS: The aim of our study was to explore differences in genetic predisposition to obesity between the Hungarian general and Roma populations. METHODS: A total of 1,152 samples from the Hungarian Roma population and 1,743 samples from the Hungarian general population were genotyped for 20 single nucleotide polymorphisms (SNPs) associated with the risk of obesity. Two types of multilocus genetic risk scores were constructed to estimate the combined effect of selected SNPs...
October 7, 2017: Obesity Facts
Sabine Makkes, Johanna M van Dongen, Carry M Renders, Olga H van der Baan-Slootweg, Jacob C Seidell, Judith E Bosmans
BACKGROUND: Considering the large economic consequences of severe childhood obesity for the society, we aimed to conduct an economic evaluation comparing two intensive 1-year lifestyle treatments with varying inpatient periods for severely obese children and adolescents with regard to standard deviation score BMI (SDS-BMI) and quality-adjusted life years (QALYs). METHODS: An economic evaluation from a societal perspective accompanying a randomized controlled trial with a 24-month follow-up...
October 7, 2017: Obesity Facts
Anwar Ahmed, Doaa AlBuraikan, Bashayr ALMuqbil, Wijdan AlJohi, Wala Alanazi, Budor AlRasheed
BACKGROUND: Saudi Arabian hospital readmissions and emergency department (ED) visits following bariatric surgery and discharge have never been investigated. This study aimed to evaluate the rates and reasons of hospital readmissions and ED visits related to surgical weight loss interventions at the King Abdulaziz Medical City - Riyadh. METHODS: We conducted a retrospective cohort study on 301 patients who underwent bariatric surgery between January 2011 and July 2016...
October 7, 2017: Obesity Facts
Tanja H Kakebeeke, Stefano Lanzi, Annina E Zysset, Amar Arhab, Nadine Messerli-Bürgy, Kerstin Stuelb, Claudia S Leeger-Aschmann, Einat A Schmutz, Andrea H Meyer, Susi Kriemler, Simone Munsch, Oskar G Jenni, Jardena J Puder
OBJECTIVE: Being overweight makes physical movement more difficult. Our aim was to investigate the association between body composition and motor performance in preschool children. METHODS: A total of 476 predominantly normal-weight preschool children (age 3.9 ± 0.7 years; m/f: 251/225; BMI 16.0 ± 1.4 kg/m2) participated in the Swiss Preschoolers' Health Study (SPLASHY). Body composition assessments included skinfold thickness, waist circumference (WC), and BMI...
September 22, 2017: Obesity Facts
(no author information available yet)
No abstract text is available yet for this article.
May 19, 2017: Obesity Facts
Barbara Bohn, Susanna Wiegand, Wieland Kiess, Thomas Reinehr, Rainer Stachow, Johannes Oepen, Helmut Langhof, Thomas Hermann, Kurt Widhalm, Martin Wabitsch, Ines Gellhaus, Reinhard Holl
OBJECTIVE: To examine whether characteristics of children and adolescents who start lifestyle intervention (LI) for obesity in Germany changed over the last decade. METHODS: 65,453 subjects (<21 years) from the APV database (Adiposity Patients Registry) with a BMI ≥ 90th percentile were included (years 2005-2015). Logistic regression models (confounders: age, sex, migration background) were created for overweight, obesity, extreme obesity, and obesity-related comorbidities...
2017: Obesity Facts
Hans Hauner, Ljiljana Hastreiter, Dieter Werdier, Annette Chen-Stute, Jürgen Scholze, Matthias Blüher
OBJECTIVE: To investigate the efficacy and safety of increasing doses of cathine (nor-pseudoephedrine) as a weight-lowering agent in patients with obesity. METHODS: Overweight and obese patients (n = 241, mean BMI 34.6 ± 3.4 kg/m²) were randomly allocated to one of three doses of cathine (16 mg, 32 mg, 53.3 mg) or placebo in addition to a multimodal lifestyle intervention program in a multicenter, double-blind, controlled, dose-finding study for 24 weeks. Primary outcome was weight loss...
2017: Obesity Facts
Louise Lylloff, Lise Bathum, Sten Madsbad, Josefine Liv Gilling Grundtvig, Inge Nordgaard-Lassen, Mogens Fenger
BACKGROUND: In obesity, which is a major contributor to insulin resistance and diabetes, the circulating level of S100A8/A9 (calprotectin) is elevated and declines after Roux-en-Y gastric bypass surgery (RYGB). However, studies on S100A8/A9 and the pathophysiological mechanisms in insulin resistance and diabetes are few and contradictory. METHODS: We studied 48 subjects who underwent RYGB, comprising a non-diabetic control group and two diabetic groups in whom diabetes either regressed or persisted, 6-12 months post-surgically...
2017: Obesity Facts
Camille Dugas, Julie Perron, Michèle Kearney, Roxanne Mercier, André Tchernof, Isabelle Marc, S John Weisnagel, Julie Robitaille
Children exposed to gestational diabetes mellitus (GDM) in utero are at high risk of developing many health problems such as obesity. There is an urgent need to find new strategies to prevent obesity development among high-risk populations such as those children. Accordingly, the aim of this review was to summarize current knowledge on the postnatal prevention of childhood obesity in offspring born from mothers with GDM. Specifically, this review addresses the impact of breastfeeding, complementary feeding practices as well as dietary intake and physical activity during childhood on obesity risk of children exposed to GDM in utero...
2017: Obesity Facts
Maaike Kruseman, Noémi Schmutz, Isabelle Carrard
OBJECTIVE: To assess dietary intake, eating patterns, physical activity and eating behaviors, and to explore strategies and perceptions of the experience of weight maintenance in weight loss maintainers (weight loss maintenance (WLM) ≥ 10% weight loss maintained for ≥1 year) and in matched controls with a lifetime stable normal weight. METHODS: Volunteers (32) were recruited by a snowball procedure in this cross-sectional, mixed-methods study. Diet, physical activity, and eating behaviors were assessed with validated questionnaires...
2017: Obesity Facts
Rocío San Martin, Julio Brito, Patricia Siques, Fabiola León-Velarde
Obesity, a worldwide epidemic, has become a major health burden because it is usually accompanied by an increased risk for insulin resistance, diabetes, hypertension, cardiovascular diseases, and even some kinds of cancer. It also results in associated increases in healthcare expenditures and labor and economic consequences. There are also other fields of medicine and biology where obesity or being overweight play a major role, such as high-altitude illnesses (acute mountain sickness, hypoxic pulmonary hypertension, and chronic mountain sickness), where an increasing relationship among these two morbid statuses has been demonstrated...
2017: Obesity Facts
Yvonne Mühlig, André Scherag, Annika Bickenbach, Ulrike Giesen, Reinhard Holl, Rolf Holle, Wieland Kiess, Belinda Lennerz, Diana Lütke Brintrup, Anja Moss, Madlen Neef, Claudia Ose, Thomas Reinehr, Christina M Teuner, Susanna Wiegand, Barbara Wolters, Martin Wabitsch, Johannes Hebebrand
BACKGROUND: To compare efficacy and safety of a manual-based low-level psychological intervention with treatment as usual (weight loss treatment). METHODS: A two-armed randomized controlled trial without blinding and computer-based stratified block randomization included adolescents and young adults (14.0-24.9 years) with a BMI ≥ 30 kg/m2 at five German university hospitals. Primary outcomes were adherence (participation rate ≥ 5/6 sessions) and quality of life (DISABKIDS-37) 6 months after randomization...
2017: Obesity Facts
Lorena Del Rocio Ibarra-Reynoso, Hilda Lissette López-Lemus, Ma Eugenia Garay-Sevilla, Juan Manuel Malacara
OBJECTIVE: We examined the effect of restriction of foods with high fructose content in obese school children. METHODS: In a clinical study, we selected 54 obese children 6 to 11 years old with high fructose consumption (>70 g/day) in order indicate dietary fructose restriction (<20 g/day) for 6 weeks. Anthropometry, liver ultrasound as well as glucose, insulin, lipids, leptin, IGFBP1, and RBP4 serum levels were collected. RESULTS: The group of children had 80% adherence and reported decreased fructose consumption (110 ± 38...
2017: Obesity Facts
Orsolya Ács, Bálint Péterfia, Péter Hollósi, Andrea Luczay, Dóra Török, András Szabó
OBJECTIVE: Worldwide increasing childhood obesity is due to interactions between environmental and genetic factors, linked together by epigenetic mechanisms such as DNA methylation. METHODS: 82 obese children (>95th BMI percentile , age: 3-18 years) were included. Anthropometric data, metabolic parameters, 25-OH vitamin D (25OHD), and pubertal status were recorded, 24-hour blood pressure monitoring was performed. BMI standard deviation score (SDS) was calculated...
2017: Obesity Facts
Nejmeddine Ouerghi, Mohamed Kacem Ben Fradj, Ikram Bezrati, Moncef Feki, Naziha Kaabachi, Anissa Bouassida
OBJECTIVES: Omentin-1 is a recently discovered adipokine, mainly produced by visceral adipose tissue, which is thought to improve insulin sensitivity. The study aimed to assess the association of plasma omentin-1 with cardiometabolic traits and physical performance and to test its response to high-intensity interval training (HIIT) in obese and normal-weight subjects. METHODS: Nine overweight/obese (OG) and 9 normal-weight (NWG) young men performed an 8-week HIIT program...
2017: Obesity Facts
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