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Thyroid Research

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https://www.readbyqxmd.com/read/30002731/effect-of-perchlorate-and-thiocyanate-exposure-on-thyroid-function-of-pregnant-women-from-south-west-england-a-cohort-study
#1
Bridget A Knight, Beverley M Shields, Xuemei He, Elizabeth N Pearce, Lewis E Braverman, Rachel Sturley, Bijay Vaidya
Background: Iodine is important for thyroid hormone synthesis, and iodine deficiency in pregnancy may impair fetal neurological development. As perchlorate and thiocyanate inhibit sodium-iodide symporter reducing the transport of iodine from circulation into the thyroid follicular cells, environmental exposure to these substances in pregnancy may impair maternal thyroid hormone synthesis. We aimed to explore the impact of perchlorate and thiocyanate exposure on thyroid status in a cohort of pregnant mothers from South West England...
2018: Thyroid Research
https://www.readbyqxmd.com/read/29942352/the-upper-limit-for-tsh-during-pregnancy-why-we-should-stop-using-fixed-limits-of-2-5-or-3-0-mu-l
#2
EDITORIAL
Tim I M Korevaar
Physiological changes necessitate the use of pregnancy-specific reference ranges for TSH and FT4 to diagnose thyroid dysfunction during pregnancy. Although many centers use fixed upper limits for TSH of 2.5 or 3.0 mU/L, this comment describeds new data which indicate that such cut-offs are too low and may lead to overdiagnosis or even overtreatment. The new guidelines of the American Thyroid Association have considerably changed recommendations regarding thyroid function reference ranges in pregnancy accordingly...
2018: Thyroid Research
https://www.readbyqxmd.com/read/29875824/characteristics-and-natural-course-of-hypoechoic-thyroid-lesions-diagnosed-as-possible-thyroid-lymphomas-by-fine-needle-aspiration-cytology
#3
Tomoe Nakao, Mitsushige Nishikawa, Mako Hisakado, Toshihiko Kasahara, Takumi Kudo, Eijun Nishihara, Mitsuru Ito, Shuji Fukata, Hirotoshi Nakamura, Mitsuyoshi Hirokawa, Akira Miyauchi
Background: There is little information regarding the natural course of hypoechoic thyroid lesions that are probable or possible thyroid lymphoma based on fine needle aspiration cytology (FNAC) results. Methods: Sixty-five patients who were diagnosed as probable or possible thyroid lymphoma by ultrasonography (US) and FNAC were investigated. Forty-three patients with strong suspicion underwent thyroid surgery for the diagnosis at our hospital, and 22 patients were followed up with periodic US examination...
2018: Thyroid Research
https://www.readbyqxmd.com/read/29875823/-does-levothyroxine-improve-pregnancy-outcomes-in-euthyroid-women-with-thyroid-autoimmunity-undergoing-assisted-reproductive-technology
#4
EDITORIAL
Kris Poppe, Flora Veltri, Candice Autin
Evidence on the treatment of euthyroid infertile women and thyroid autoimmunity with thyroid hormone is scare, and therefore the recent study by Wang et al. is a welcome addition to it. Based on their results, thyroid hormone seems not to be indicated to decrease the miscarriage rate in that particular group of infertile women. This comment is meant to put the study results into perspective with the available evidence and the current guidelines, and to highlight its strengths and weaknesses.
2018: Thyroid Research
https://www.readbyqxmd.com/read/29849767/thyroid-hormones-increase-stomach-goblet-cell-numbers-and-mucin-expression-during-indomethacin-induced-ulcer-healing-in-wistar-rats
#5
Jackline Namulema, Miriam Nansunga, Charles Drago Kato, Muhammudu Kalange, Samuel Babafemi Olaleye
Background: Gastric ulcers are mucosal discontinuities that may extend into the mucosa, submucosa or even deeper. They result from an imbalance between mucosal aggressors and protective mechanisms that include the mucus bicarbonate layer. Thyroid hormones have been shown to accelerate gastric ulcer healing in part by increasing the adherent mucus levels. However, the effects of thyroid hormones on goblet cell numbers and expression of neutral and acidic mucins during ulcer healing have not been investigated...
2018: Thyroid Research
https://www.readbyqxmd.com/read/29785209/acute-suppurative-thyroiditis-caused-by-thyroid-papillary-carcinoma-in-the-right-thyroid-lobe-of-a-healthy-woman
#6
Hazuki Otani, Masakazu Notsu, Sayo Koike, Miwa Morita, Masahiro Yamamoto, Mika Yamauchi, Takahumi Fuchiwaki, Ichiro Morikura, Noriaki Aoi, Hideyuki Kawauchi, Teruaki Iwabashi, Asuka Araki, Noriyoshi Ishikawa, Riruke Maruyama, Toshitsugu Sugimoto
Background: The thyroid gland is resistant to microbial infection, because of its organ characteristics such as encapsulation, iodine content, and rich blood supply. Therefore, acute suppurative thyroiditis (AST), as a bacterial infection of the thyroid gland, is rarely seen. AST typically takes places on the left side the neck region in children, because of the coincidence of the left piriform sinus fistula, as a most common route of infection. AST is also usually seen in immunocompromised hosts...
2018: Thyroid Research
https://www.readbyqxmd.com/read/29760786/ultrasound-criteria-for-risk-stratification-of-thyroid-nodules-in-the-previously-iodine-deficient-area-of-austria-a-single-centre-retrospective-analysis
#7
Christina Tugendsam, Veronika Petz, Wolfgang Buchinger, Brigitta Schmoll-Hauer, Iris Pia Schenk, Karin Rudolph, Michael Krebs, Georg Zettinig
Background: We aimed to study the validity of six published ultrasound criteria for risk stratification of thyroid nodules in the former severely iodine deficient population of Austria. Methods: Retrospective, single centre, observer blinded study design. All patients with a history of thyroidectomy due to nodules seen in the centre between 2004 and 2014 with preoperative in-house sonography and documented postoperative histology were analyzed ( n  = 195). A board of five experienced thyroidologists evaluated the images of 45 papillary carcinomas, 8 follicular carcinomas, and 142 benign nodules regarding the following criteria: mild hypoechogenicity, marked hypoechogenicity, microlobulated or irregular margins, microcalcifications, taller than wide shape, missing thin halo...
2018: Thyroid Research
https://www.readbyqxmd.com/read/29449887/role-of-the-t-and-b-lymphocytes-in-pathogenesis-of-autoimmune-thyroid-diseases
#8
Marta Rydzewska, Michał Jaromin, Izabela Elżbieta Pasierowska, Karlina Stożek, Artur Bossowski
Autoimmune thyroid disorders (AITD) broadly include Graves' disease and Hashimoto's thyroiditis which are the most common causes of thyroid gland dysfunctions. These disorders develop due to complex interactions between environmental and genetic factors and are characterized by reactivity to self-thyroid antigens due to autoreactive lymphocytes escaping tolerance. Both cell-mediated and humoral responses lead to tissue injury in autoimmune thyroid disease. The differentiation of CD4+ cells in the specific setting of immune mediators (for example cytokines, chemokines) results in differentiation of various T cell subsets...
2018: Thyroid Research
https://www.readbyqxmd.com/read/29375671/management-of-hypothyroidism-with-combination-thyroxine-t4-and-triiodothyronine-t3-hormone-replacement-in-clinical-practice-a-review-of-suggested-guidance
#9
REVIEW
Colin Dayan, Vijay Panicker
Background: Whilst trials of combination levothyroxine/liothyronine therapy versus levothyroxine monotherapy for thyroid hormone replacement have not shown any superiority, there remains a small subset of patients who do not feel well on monotherapy. Whilst current guidelines do not suggest routine use of combination therapy they do acknowledge a trial in such patients may be appropriate. It appears that use of combination therapy and dessicated thyroid extract is not uncommon but often being used by non-specialists and not adequately monitored...
2018: Thyroid Research
https://www.readbyqxmd.com/read/29051792/papillary-thyroid-cancer-recurrence-43-years-following-total-thyroidectomy-and-radioactive-iodine-ablation-a-case-report
#10
Yaw Amoako-Tuffour, M Elise Graham, Martin Bullock, Matthew H Rigby, Jonathan Trites, S Mark Taylor, Robert D Hart
BACKGROUND: Recurrent papillary thyroid carcinoma (PTC) beyond the first two decades of definitive treatment (i.e. total thyroidectomy and radioactive iodine ablation) is a rare occurrence. CASE PRESENTATION: We present a case of a 71-year old Caucasian female with a distant history of PTC treated with total thyroidectomy and radioactive iodine ablation who experienced recurrence of her disease 43 years following initial diagnosis and definitive treatment. She presented with palpable left-sided neck mass and subsequently underwent a level II, III, neck dissection and adjuvant iodine ablation...
2017: Thyroid Research
https://www.readbyqxmd.com/read/29051791/hyalinizing-trabecular-tumor-of-the-thyroid-gland-and-its-significant-diagnostic-issue
#11
Dustin J Jones, Christopher R Kieliszak, Sanjay S Patel, Christopher R Selinsky
BACKGROUND: Hyalinizing trabecular tumors (HTT) are rare follicular cell-derived tumors of the thyroid gland that are infrequently reported in otolaryngology literature. We present here an interesting case of HTT which provides the basis for review of this entity's clinical characteristics, criteria useful in making the diagnosis, and any currently available therapeutic modalities. CASE PRESENTATION: A 70-year-old Caucasian female underwent a CT scan of her chest and was incidentally found to have a nodule within the right thyroid lobe...
2017: Thyroid Research
https://www.readbyqxmd.com/read/28932277/a-retrospective-review-of-the-multidisciplinary-management-of-medullary-thyroid-cancer-eligibility-for-systemic-therapy
#12
Georgia Geller, Janessa Laskin, Winson Y Cheung, Cheryl Ho
BACKGROUND: Medullary thyroid carcinoma (MTC) accounts for 1-2% of all thyroid cancers. The clinical course of metastatic disease can be indolent. Our aim was to characterize the natural history of disease to evaluate the true proportion of patients who would be eligible for the currently available systemic therapies. METHODS: The British Columbia Cancer Agency (BCCA) provides cancer care to a population of 4.6 million. A retrospective chart review was conducted of all patients with MTC referred to the BCCA from 1991 to 2013...
2017: Thyroid Research
https://www.readbyqxmd.com/read/28804518/comparative-frequency-of-four-different-types-of-pregnancy-associated-thyrotoxicosis-in-a-single-thyroid-centre
#13
Akane Ide, Nobuyuki Amino, Takumi Kudo, Waka Yoshioka, Mako Hisakado, Eijun Nishihara, Mitsuru Ito, Shuji Fukata, Hirotoshi Nakamura, Akira Miyauchi
BACKGROUND: Pregnancy and delivery markedly influence thyroid function. However, the comparative prevalence of gestational thyrotoxicosis (GT), new onset of Graves' disease during pregnancy (GD during pregnancy), postpartum destructive thyrotoxicosis (PPT), and postpartum Graves' thyrotoxicosis (PPGD) has not yet been determined. METHODS: We prospectively registered and performed a review of 4127 consecutive non treated female patients with thyrotoxicosis, seen between August 2008 and December 2013 in our outpatient clinic of Kuma Hospital...
2017: Thyroid Research
https://www.readbyqxmd.com/read/28572843/malignant-struma-ovarii-in-a-30-year-old-nulliparous-patient
#14
J Colin Boyd, Blair A Williams, Matthew H Rigby, Katharina Kieser, Saul Offman, Hemlata Shirsat, Jonathan R B Trites, S Mark Taylor, Robert D Hart
BACKGROUND: Struma ovarii is a rare monodermal germ cell tumor where the ovary is comprised of at least half thyroid tissue. This phenomenon may indicate an embryological origin. CASE PRESENTATION: A 30-year old nulliparous woman presented with acute right lower quadrant pain and underwent laparoscopic right salpingo-oophorectomy. The excised ovarian mass showed evidence of struma-derived papillary thyroid carcinoma. Ultrasound of the thyroid showed mild enlargement with two solid nodules...
2017: Thyroid Research
https://www.readbyqxmd.com/read/28184253/concordance-between-the-tirads-ultrasound-criteria-and-the-bethesda-cytology-criteria-on-the-nontoxic-thyroid-nodule
#15
Hernando Vargas-Uricoechea, Ivonne Meza-Cabrera, Jorge Herrera-Chaparro
BACKGROUND: Thyroid nodule is a common disorder of the thyroid. Despite their benign nature, they can be associated with multiple pathologic conditions, including thyroid cancer. METHODS: This cross-sectional study determined the concordance of Ultrasound (TIRADS criteria) and Fine Needle Aspiration Biopsy (FNA-BETHESDA system) in the assessment of the nontoxic thyroid nodule. A total of 180 subjects 18 years old or older underwent the two diagnostic tests and their results were compared using kappa index...
2017: Thyroid Research
https://www.readbyqxmd.com/read/27766119/study-of-optimal-replacement-of-thyroxine-in-the-elderly-sorted-results-from-the-feasibility-randomised-controlled-trial
#16
Salman Razvi, Lorna Ingoe, Vicky Ryan, Simon H S Pearce, Scott Wilkes
BACKGROUND: Hypothyroidism is a common condition, particularly in the older population. Thyroid hormone requirements change with age and serum TSH levels also alter, especially in older patients. However, in practice laboratory reference ranges for thyroid function are not age-specific and treatment in older patients aims to achieve a similar target thyroid function level as younger age groups. METHODS: A dual centre, single blind, randomised controlled trial was conducted to determine the feasibility of a future definitive RCT in hypothyroid individuals aged 80 years or older who were treated with levothyroxine...
2016: Thyroid Research
https://www.readbyqxmd.com/read/27313663/predicting-malignancy-in-thyroid-nodules-feasibility-of-a-predictive-model-integrating-clinical-biochemical-and-ultrasound-characteristics
#17
Justyna Witczak, Peter Taylor, Jason Chai, Bethan Amphlett, Jean-Marc Soukias, Gautam Das, Brian P Tennant, John Geen, Onyebuchi E Okosieme
BACKGROUND: Although the majority of thyroid nodules are benign the process of excluding malignancy is challenging and sometimes involves unnecessary surgical procedures. We explored the development of a predictive model for malignancy in thyroid nodules by integrating a combination of simple demographic, biochemical, and ultrasound characteristics. METHODS: Retrospective case-record review. We reviewed records of patients with thyroid nodules referred to our institution from 2004 to 2011 (n = 536; female 84 %, mean age 51 years)...
2016: Thyroid Research
https://www.readbyqxmd.com/read/26985239/thyroid-research-stepping-forward
#18
Bijay Vaidya, Andrzej Lewinski
It is eight years since Thyroid Research was launched with an aim to enhance opportunities for scientists and clinicians, working in the rapidly advancing field of thyroidology, to publish their research (Thyroid Res 1(1):1, 2008). Right from the outset, Thyroid Research aspired to become a prominent journal in thyroidology with high quality publications. Over the years, the journal has not only survived in the increasingly competitive field of open-access academic journal publication, it has also been making a steady progress towards achieving this ambitious goal...
2016: Thyroid Research
https://www.readbyqxmd.com/read/26819633/association-between-iron-status-and-thyroid-function-in-nepalese-children
#19
Saroj Khatiwada, Basanta Gelal, Nirmal Baral, Madhab Lamsal
BACKGROUND: Deficiencies of iodine and iron may have adverse effect on thyroid function. This study was undertaken to investigate the association between iron status and thyroid function in Nepalese children living in hilly regions. METHODS: A cross-sectional study was conducted among 227 school children aged 6-12 years living in hilly regions of eastern Nepal. Urine and blood samples were analyzed for urinary iodine concentration, free thyroxine, free triiodothyronine, thyroid stimulating hormone, hemoglobin, serum iron and total iron binding capacity, and percentage transferrin saturation was calculated...
2016: Thyroid Research
https://www.readbyqxmd.com/read/26779284/pendulum-swings-from-hypo-to-hyperthyroidism-thyrotoxicosis-after-severe-hypothyroidism-following-neck-irradiation-in-a-patient-with-a-history-of-hodgkin-s-lymphoma
#20
Krzysztof Lewandowski, Katarzyna Dąbrowska, Jacek Makarewicz, Andrzej Lewiński
BACKGROUND: A change in a thyrometabolic state from severe hypothyroidism to thyrotoxicosis is very uncommon, but possible in some circumstances. CASE PRESENTATION: A 27-year old female presented with clinical and biochemical thyrotoxicosis with a previous history chemo- and radiotherapy (including the neck region) for a Hodgkin's lymphoma (at the age of 18). At the age of 20 this was followed by severe hypothyrodism [TSH > 100 μIU/mL (reference range: 0...
2016: Thyroid Research
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