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Thyroid Research

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https://www.readbyqxmd.com/read/28932277/a-retrospective-review-of-the-multidisciplinary-management-of-medullary-thyroid-cancer-eligibility-for-systemic-therapy
#1
Georgia Geller, Janessa Laskin, Winson Y Cheung, Cheryl Ho
BACKGROUND: Medullary thyroid carcinoma (MTC) accounts for 1-2% of all thyroid cancers. The clinical course of metastatic disease can be indolent. Our aim was to characterize the natural history of disease to evaluate the true proportion of patients who would be eligible for the currently available systemic therapies. METHODS: The British Columbia Cancer Agency (BCCA) provides cancer care to a population of 4.6 million. A retrospective chart review was conducted of all patients with MTC referred to the BCCA from 1991 to 2013...
2017: Thyroid Research
https://www.readbyqxmd.com/read/28804518/comparative-frequency-of-four-different-types-of-pregnancy-associated-thyrotoxicosis-in-a-single-thyroid-centre
#2
Akane Ide, Nobuyuki Amino, Takumi Kudo, Waka Yoshioka, Mako Hisakado, Eijun Nishihara, Mitsuru Ito, Shuji Fukata, Hirotoshi Nakamura, Akira Miyauchi
BACKGROUND: Pregnancy and delivery markedly influence thyroid function. However, the comparative prevalence of gestational thyrotoxicosis (GT), new onset of Graves' disease during pregnancy (GD during pregnancy), postpartum destructive thyrotoxicosis (PPT), and postpartum Graves' thyrotoxicosis (PPGD) has not yet been determined. METHODS: We prospectively registered and performed a review of 4127 consecutive non treated female patients with thyrotoxicosis, seen between August 2008 and December 2013 in our outpatient clinic of Kuma Hospital...
2017: Thyroid Research
https://www.readbyqxmd.com/read/28572843/malignant-struma-ovarii-in-a-30-year-old-nulliparous-patient
#3
J Colin Boyd, Blair A Williams, Matthew H Rigby, Katharina Kieser, Saul Offman, Hemlata Shirsat, Jonathan R B Trites, S Mark Taylor, Robert D Hart
BACKGROUND: Struma ovarii is a rare monodermal germ cell tumor where the ovary is comprised of at least half thyroid tissue. This phenomenon may indicate an embryological origin. CASE PRESENTATION: A 30-year old nulliparous woman presented with acute right lower quadrant pain and underwent laparoscopic right salpingo-oophorectomy. The excised ovarian mass showed evidence of struma-derived papillary thyroid carcinoma. Ultrasound of the thyroid showed mild enlargement with two solid nodules...
2017: Thyroid Research
https://www.readbyqxmd.com/read/28184253/concordance-between-the-tirads-ultrasound-criteria-and-the-bethesda-cytology-criteria-on-the-nontoxic-thyroid-nodule
#4
Hernando Vargas-Uricoechea, Ivonne Meza-Cabrera, Jorge Herrera-Chaparro
BACKGROUND: Thyroid nodule is a common disorder of the thyroid. Despite their benign nature, they can be associated with multiple pathologic conditions, including thyroid cancer. METHODS: This cross-sectional study determined the concordance of Ultrasound (TIRADS criteria) and Fine Needle Aspiration Biopsy (FNA-BETHESDA system) in the assessment of the nontoxic thyroid nodule. A total of 180 subjects 18 years old or older underwent the two diagnostic tests and their results were compared using kappa index...
2017: Thyroid Research
https://www.readbyqxmd.com/read/27766119/study-of-optimal-replacement-of-thyroxine-in-the-elderly-sorted-results-from-the-feasibility-randomised-controlled-trial
#5
Salman Razvi, Lorna Ingoe, Vicky Ryan, Simon H S Pearce, Scott Wilkes
BACKGROUND: Hypothyroidism is a common condition, particularly in the older population. Thyroid hormone requirements change with age and serum TSH levels also alter, especially in older patients. However, in practice laboratory reference ranges for thyroid function are not age-specific and treatment in older patients aims to achieve a similar target thyroid function level as younger age groups. METHODS: A dual centre, single blind, randomised controlled trial was conducted to determine the feasibility of a future definitive RCT in hypothyroid individuals aged 80 years or older who were treated with levothyroxine...
2016: Thyroid Research
https://www.readbyqxmd.com/read/27313663/predicting-malignancy-in-thyroid-nodules-feasibility-of-a-predictive-model-integrating-clinical-biochemical-and-ultrasound-characteristics
#6
Justyna Witczak, Peter Taylor, Jason Chai, Bethan Amphlett, Jean-Marc Soukias, Gautam Das, Brian P Tennant, John Geen, Onyebuchi E Okosieme
BACKGROUND: Although the majority of thyroid nodules are benign the process of excluding malignancy is challenging and sometimes involves unnecessary surgical procedures. We explored the development of a predictive model for malignancy in thyroid nodules by integrating a combination of simple demographic, biochemical, and ultrasound characteristics. METHODS: Retrospective case-record review. We reviewed records of patients with thyroid nodules referred to our institution from 2004 to 2011 (n = 536; female 84 %, mean age 51 years)...
2016: Thyroid Research
https://www.readbyqxmd.com/read/26985239/thyroid-research-stepping-forward
#7
Bijay Vaidya, Andrzej Lewinski
It is eight years since Thyroid Research was launched with an aim to enhance opportunities for scientists and clinicians, working in the rapidly advancing field of thyroidology, to publish their research (Thyroid Res 1(1):1, 2008). Right from the outset, Thyroid Research aspired to become a prominent journal in thyroidology with high quality publications. Over the years, the journal has not only survived in the increasingly competitive field of open-access academic journal publication, it has also been making a steady progress towards achieving this ambitious goal...
2016: Thyroid Research
https://www.readbyqxmd.com/read/26819633/association-between-iron-status-and-thyroid-function-in-nepalese-children
#8
Saroj Khatiwada, Basanta Gelal, Nirmal Baral, Madhab Lamsal
BACKGROUND: Deficiencies of iodine and iron may have adverse effect on thyroid function. This study was undertaken to investigate the association between iron status and thyroid function in Nepalese children living in hilly regions. METHODS: A cross-sectional study was conducted among 227 school children aged 6-12 years living in hilly regions of eastern Nepal. Urine and blood samples were analyzed for urinary iodine concentration, free thyroxine, free triiodothyronine, thyroid stimulating hormone, hemoglobin, serum iron and total iron binding capacity, and percentage transferrin saturation was calculated...
2016: Thyroid Research
https://www.readbyqxmd.com/read/26779284/pendulum-swings-from-hypo-to-hyperthyroidism-thyrotoxicosis-after-severe-hypothyroidism-following-neck-irradiation-in-a-patient-with-a-history-of-hodgkin-s-lymphoma
#9
Krzysztof Lewandowski, Katarzyna Dąbrowska, Jacek Makarewicz, Andrzej Lewiński
BACKGROUND: A change in a thyrometabolic state from severe hypothyroidism to thyrotoxicosis is very uncommon, but possible in some circumstances. CASE PRESENTATION: A 27-year old female presented with clinical and biochemical thyrotoxicosis with a previous history chemo- and radiotherapy (including the neck region) for a Hodgkin's lymphoma (at the age of 18). At the age of 20 this was followed by severe hypothyrodism [TSH > 100 μIU/mL (reference range: 0...
2016: Thyroid Research
https://www.readbyqxmd.com/read/28256966/spring-school-of-thyroidology-organized-by-the-polish-thyroid-association-2014-abstracts-of-invited-lectures
#10
(no author information available yet)
No abstract text is available yet for this article.
June 22, 2015: Thyroid Research
https://www.readbyqxmd.com/read/26649074/iodine-prophylaxis-in-pregnant-women-in-poland-where-we-are-update-2015
#11
Arkadiusz Zygmunt, Andrzej Lewinski
Introduction of the model of iodine prophylaxis based on the consumption of iodized salt in 1997 has eliminated the iodine deficiency in Poland. However, in accordance with the current recommendations, all women who are planning to be pregnant or are pregnant or breastfeeding should receive an additional dose of iodine at 150-200 mcg / day because of the increased body's need for iodine during this period. Studies show that only part of women in Poland conduct a proper iodine prophylaxis and it is often initiated in the second and third trimester of pregnancy...
2015: Thyroid Research
https://www.readbyqxmd.com/read/26628920/a-single-bolus-of-high-dose-levothyroxine-l-t4-as-a-test-in-cases-of-suspected-poor-compliance-to-l-t4-therapy
#12
Krzysztof C Lewandowski, Katarzyna Dąbrowska, Iwona Komorowska-Dudek, Andrzej Lewiński
BACKGROUND: Though compliance (or adherence) problems, as well as inappropriate levothyroxine (L-T4) intake (e.g. with meal, other drugs or certain foods that can significantly affect absorption) are very common, the issue is often either not mentioned or even frankly denied by patients. CASE PRESENTATION: We describe three cases of patients who presented with high TSH (ranging from about 30 to 200 mIU/l), with concomitantly either high, normal or low free thyroxine (FT4), despite treatment with high doses of L-T4...
2015: Thyroid Research
https://www.readbyqxmd.com/read/26430471/a-systematic-review-and-meta-analysis-of-harmonic-focus-in-thyroidectomy-compared-to-conventional-techniques
#13
REVIEW
Hang Cheng, Ireena Soleas, Nicole C Ferko, Jeffrey W Clymer, Joseph F Amaral
INTRODUCTION: Several meta-analyses have been performed comparing the use of a variety of ultrasonic devices in thyroidectomy to conventional procedures. These studies have shown the superiority of ultrasonic devices for most outcomes studied including faster operative time and less blood loss, and equivalent or better safety for recurrent laryngeal nerve paresis and hypocalcemia. The current work is the first to examine a single ultrasonic device specifically designed for thyroid surgery, the Harmonic Focus, in order to confirm its efficacy and safety in thyroidectomy...
2015: Thyroid Research
https://www.readbyqxmd.com/read/26339294/the-impact-of-lithium-on-thyroid-function-in-chinese-psychiatric-population
#14
Kwan Yee Queenie Tsui
BACKGROUND: Lithium was known to cause thyroid dysfunction and most commonly subclinical hypothyroidism (SCH). The aim of this study is to determine the prevalence of Lithium associated thyroid dysfunction and to identify risk factors associated with development of SCH in patients receiving Lithium. METHODS: A retrospective cross-sectional study was conducted. Subjects who developed elated thyroid stimulating hormone (TSH) were compared with those who remained euthyroid with Lithium treatment...
2015: Thyroid Research
https://www.readbyqxmd.com/read/26300979/the-value-of-thyroperoxidase-as-a-prognostic-factor-for-differentiated-thyroid-cancer-a-long-term-follow-up-study
#15
Yurena Caballero, Eudaldo M López-Tomassetti, Julián Favre, José R Santana, Juan J Cabrera, Juan R Hernández
BACKGROUND: Thyroperoxidase (TPO) is a membrane-bound protein essential for the production of thyroid hormones; because of this, TPO expression may be impaired in selected thyroid diseases. The goal of this study is to analyze TPO immune expression in differentiated thyroid cancer, and to determine whether TPO has any prognostic value. METHODS: A total of 139 patients who required surgery due to a thyroid nodule with signs or symptoms suspicious for malignancy during their physical, ultrasound and/or cytology examination were consecutively selected for the study...
2015: Thyroid Research
https://www.readbyqxmd.com/read/26273323/apoptosis-induction-by-combination-of-drugs-or-a-conjugated-molecule-associating-non-steroidal-anti-inflammatory-and-nitric-oxide-donor-effects-in-medullary-thyroid-cancer-models-implication-of-the-tumor-suppressor-p73
#16
Thierry Ragot, Claire Provost, Aurélie Prignon, Régis Cohen, Michel Lepoivre, Sylvie Lausson
BACKGROUND: Medullary thyroid cancer (MTC) is a C-cell neoplasm. Surgery remains its main treatment. Promising therapies based on tyrosine kinase inhibitors demand careful patient selection. We previously observed that two non-steroidal anti-inflammatory drugs (NSAID), indomethacin, celecoxib, and nitric oxide (NO) prevented tumor growth in a model of human MTC cell line (TT) in nude mice. METHODS: In the present study, we tested the NO donor: glyceryl trinitrate (GTN), at pharmacological dose, alone and in combination with each of the two NSAIDs on TT cells...
2015: Thyroid Research
https://www.readbyqxmd.com/read/26244057/circulating-thyrotropin-receptor-messenger-ribonucleic-acid-is-not-an-effective-marker-in-the-follow-up-of-differentiated-thyroid-carcinoma
#17
Surasawadee Ausavarat, Jiraporn Sriprapaporn, Busara Satayaban, Wanna Thongnoppakhun, Aunchalee Laipiriyakun, Boontham Amornkitticharoen, Rujaporn Chanachai, Chaveevan Pattanachak
BACKGROUND: Circulating thyrotropin receptor messenger ribonucleic acid (TSHR mRNA) assay has been validated in the follow-up of differentiated thyroid carcinoma (DTC) because of its high sensitivity during thyroid hormone therapy and no interference with endogenous anti-thyroglobulin antibodies (TgAb) compared to serum thyroglobulin (Tg). We investigated the efficacy of TSHR mRNA assay in 160 DTC patients using quantitative PCR (qPCR). FINDINGS: Only TSHR mRNA level of structural persistent disease with TgAb-positive (3...
2015: Thyroid Research
https://www.readbyqxmd.com/read/26157488/the-ratio-of-serum-free-triiodothyronine-to-free-thyroxine-in-children-a-retrospective-database-survey-of-healthy-short-individuals-and-patients-with-severe-thyroid-hypoplasia-or-central-hypothyroidism
#18
Yuji Oto, Koji Muroya, Junko Hanakawa, Yumi Asakura, Masanori Adachi
BACKGROUND: The ratio of serum free triiodothyronine (FT3) to free thyroxine (FT4) has been shown to be constant in healthy adults. However, this ratio has been found to be decreased in athyreotic adult patients on levothyroxine (L-T4) supplementation. In order to better evaluate thyroid-related pathologies in children as well as to establish a reference range, we investigated the FT3/FT4 ratio in a pediatric population. Furthermore, we evaluated this ratio in children with congenital hypothyroidism as well as those with central hypothyroidism...
2015: Thyroid Research
https://www.readbyqxmd.com/read/26157487/thyroid-hormones-and-functional-outcomes-after-ischemic-stroke
#19
Lena M O'Keefe, Sarah E Conway, Alexandra Czap, Carl D Malchoff, Sharon Benashski, Gilbert Fortunato, Ilene Staff, Louise D McCullough
BACKGROUND: Stroke is the fifth leading cause of death and the primary cause of long-term adult disability in the United States. Increasing evidence suggests that low T3 levels immediately following acute ischemic stroke are associated with greater stroke severity, higher mortality rates, and poorer functional outcomes. Prognosis is also poor in critically ill hospitalized patients who have non-thyroidal illness syndrome (NTIS), where T3 levels are low, but TSH is normal. However, data regarding the association between TSH levels and functional outcomes are contradictory...
2015: Thyroid Research
https://www.readbyqxmd.com/read/26146517/iodine-intake-as-a-risk-factor-for-thyroid-cancer-a-comprehensive-review-of-animal-and-human-studies
#20
Michael B Zimmermann, Valeria Galetti
Thyroid cancer (TC) is the most common endocrine malignancy and in most countries, incidence rates are increasing. Although differences in population iodine intake are a determinant of benign thyroid disorders, the role of iodine intake in TC remains uncertain. We review the evidence linking iodine intake and TC from animal studies, ecological studies of iodine intake and differentiated and undifferentiated TC, iodine intake and mortality from TC and occult TC at autopsy, as well as the case-control and cohort studies of TC and intake of seafood and milk products...
2015: Thyroid Research
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