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Thyroid Research

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https://www.readbyqxmd.com/read/27766119/study-of-optimal-replacement-of-thyroxine-in-the-elderly-sorted-results-from-the-feasibility-randomised-controlled-trial
#1
Salman Razvi, Lorna Ingoe, Vicky Ryan, Simon H S Pearce, Scott Wilkes
BACKGROUND: Hypothyroidism is a common condition, particularly in the older population. Thyroid hormone requirements change with age and serum TSH levels also alter, especially in older patients. However, in practice laboratory reference ranges for thyroid function are not age-specific and treatment in older patients aims to achieve a similar target thyroid function level as younger age groups. METHODS: A dual centre, single blind, randomised controlled trial was conducted to determine the feasibility of a future definitive RCT in hypothyroid individuals aged 80 years or older who were treated with levothyroxine...
2016: Thyroid Research
https://www.readbyqxmd.com/read/27313663/predicting-malignancy-in-thyroid-nodules-feasibility-of-a-predictive-model-integrating-clinical-biochemical-and-ultrasound-characteristics
#2
Justyna Witczak, Peter Taylor, Jason Chai, Bethan Amphlett, Jean-Marc Soukias, Gautam Das, Brian P Tennant, John Geen, Onyebuchi E Okosieme
BACKGROUND: Although the majority of thyroid nodules are benign the process of excluding malignancy is challenging and sometimes involves unnecessary surgical procedures. We explored the development of a predictive model for malignancy in thyroid nodules by integrating a combination of simple demographic, biochemical, and ultrasound characteristics. METHODS: Retrospective case-record review. We reviewed records of patients with thyroid nodules referred to our institution from 2004 to 2011 (n = 536; female 84 %, mean age 51 years)...
2016: Thyroid Research
https://www.readbyqxmd.com/read/26985239/thyroid-research-stepping-forward
#3
Bijay Vaidya, Andrzej Lewinski
It is eight years since Thyroid Research was launched with an aim to enhance opportunities for scientists and clinicians, working in the rapidly advancing field of thyroidology, to publish their research (Thyroid Res 1(1):1, 2008). Right from the outset, Thyroid Research aspired to become a prominent journal in thyroidology with high quality publications. Over the years, the journal has not only survived in the increasingly competitive field of open-access academic journal publication, it has also been making a steady progress towards achieving this ambitious goal...
2016: Thyroid Research
https://www.readbyqxmd.com/read/26819633/association-between-iron-status-and-thyroid-function-in-nepalese-children
#4
Saroj Khatiwada, Basanta Gelal, Nirmal Baral, Madhab Lamsal
BACKGROUND: Deficiencies of iodine and iron may have adverse effect on thyroid function. This study was undertaken to investigate the association between iron status and thyroid function in Nepalese children living in hilly regions. METHODS: A cross-sectional study was conducted among 227 school children aged 6-12 years living in hilly regions of eastern Nepal. Urine and blood samples were analyzed for urinary iodine concentration, free thyroxine, free triiodothyronine, thyroid stimulating hormone, hemoglobin, serum iron and total iron binding capacity, and percentage transferrin saturation was calculated...
2016: Thyroid Research
https://www.readbyqxmd.com/read/26779284/pendulum-swings-from-hypo-to-hyperthyroidism-thyrotoxicosis-after-severe-hypothyroidism-following-neck-irradiation-in-a-patient-with-a-history-of-hodgkin-s-lymphoma
#5
Krzysztof Lewandowski, Katarzyna Dąbrowska, Jacek Makarewicz, Andrzej Lewiński
BACKGROUND: A change in a thyrometabolic state from severe hypothyroidism to thyrotoxicosis is very uncommon, but possible in some circumstances. CASE PRESENTATION: A 27-year old female presented with clinical and biochemical thyrotoxicosis with a previous history chemo- and radiotherapy (including the neck region) for a Hodgkin's lymphoma (at the age of 18). At the age of 20 this was followed by severe hypothyrodism [TSH > 100 μIU/mL (reference range: 0...
2016: Thyroid Research
https://www.readbyqxmd.com/read/26649074/iodine-prophylaxis-in-pregnant-women-in-poland-where-we-are-update-2015
#6
Arkadiusz Zygmunt, Andrzej Lewinski
Introduction of the model of iodine prophylaxis based on the consumption of iodized salt in 1997 has eliminated the iodine deficiency in Poland. However, in accordance with the current recommendations, all women who are planning to be pregnant or are pregnant or breastfeeding should receive an additional dose of iodine at 150-200 mcg / day because of the increased body's need for iodine during this period. Studies show that only part of women in Poland conduct a proper iodine prophylaxis and it is often initiated in the second and third trimester of pregnancy...
2015: Thyroid Research
https://www.readbyqxmd.com/read/26628920/a-single-bolus-of-high-dose-levothyroxine-l-t4-as-a-test-in-cases-of-suspected-poor-compliance-to-l-t4-therapy
#7
Krzysztof C Lewandowski, Katarzyna Dąbrowska, Iwona Komorowska-Dudek, Andrzej Lewiński
BACKGROUND: Though compliance (or adherence) problems, as well as inappropriate levothyroxine (L-T4) intake (e.g. with meal, other drugs or certain foods that can significantly affect absorption) are very common, the issue is often either not mentioned or even frankly denied by patients. CASE PRESENTATION: We describe three cases of patients who presented with high TSH (ranging from about 30 to 200 mIU/l), with concomitantly either high, normal or low free thyroxine (FT4), despite treatment with high doses of L-T4...
2015: Thyroid Research
https://www.readbyqxmd.com/read/26430471/a-systematic-review-and-meta-analysis-of-harmonic-focus-in-thyroidectomy-compared-to-conventional-techniques
#8
REVIEW
Hang Cheng, Ireena Soleas, Nicole C Ferko, Jeffrey W Clymer, Joseph F Amaral
INTRODUCTION: Several meta-analyses have been performed comparing the use of a variety of ultrasonic devices in thyroidectomy to conventional procedures. These studies have shown the superiority of ultrasonic devices for most outcomes studied including faster operative time and less blood loss, and equivalent or better safety for recurrent laryngeal nerve paresis and hypocalcemia. The current work is the first to examine a single ultrasonic device specifically designed for thyroid surgery, the Harmonic Focus, in order to confirm its efficacy and safety in thyroidectomy...
2015: Thyroid Research
https://www.readbyqxmd.com/read/26339294/the-impact-of-lithium-on-thyroid-function-in-chinese-psychiatric-population
#9
Kwan Yee Queenie Tsui
BACKGROUND: Lithium was known to cause thyroid dysfunction and most commonly subclinical hypothyroidism (SCH). The aim of this study is to determine the prevalence of Lithium associated thyroid dysfunction and to identify risk factors associated with development of SCH in patients receiving Lithium. METHODS: A retrospective cross-sectional study was conducted. Subjects who developed elated thyroid stimulating hormone (TSH) were compared with those who remained euthyroid with Lithium treatment...
2015: Thyroid Research
https://www.readbyqxmd.com/read/26300979/the-value-of-thyroperoxidase-as-a-prognostic-factor-for-differentiated-thyroid-cancer-a-long-term-follow-up-study
#10
Yurena Caballero, Eudaldo M López-Tomassetti, Julián Favre, José R Santana, Juan J Cabrera, Juan R Hernández
BACKGROUND: Thyroperoxidase (TPO) is a membrane-bound protein essential for the production of thyroid hormones; because of this, TPO expression may be impaired in selected thyroid diseases. The goal of this study is to analyze TPO immune expression in differentiated thyroid cancer, and to determine whether TPO has any prognostic value. METHODS: A total of 139 patients who required surgery due to a thyroid nodule with signs or symptoms suspicious for malignancy during their physical, ultrasound and/or cytology examination were consecutively selected for the study...
2015: Thyroid Research
https://www.readbyqxmd.com/read/26273323/apoptosis-induction-by-combination-of-drugs-or-a-conjugated-molecule-associating-non-steroidal-anti-inflammatory-and-nitric-oxide-donor-effects-in-medullary-thyroid-cancer-models-implication-of-the-tumor-suppressor-p73
#11
Thierry Ragot, Claire Provost, Aurélie Prignon, Régis Cohen, Michel Lepoivre, Sylvie Lausson
BACKGROUND: Medullary thyroid cancer (MTC) is a C-cell neoplasm. Surgery remains its main treatment. Promising therapies based on tyrosine kinase inhibitors demand careful patient selection. We previously observed that two non-steroidal anti-inflammatory drugs (NSAID), indomethacin, celecoxib, and nitric oxide (NO) prevented tumor growth in a model of human MTC cell line (TT) in nude mice. METHODS: In the present study, we tested the NO donor: glyceryl trinitrate (GTN), at pharmacological dose, alone and in combination with each of the two NSAIDs on TT cells...
2015: Thyroid Research
https://www.readbyqxmd.com/read/26244057/circulating-thyrotropin-receptor-messenger-ribonucleic-acid-is-not-an-effective-marker-in-the-follow-up-of-differentiated-thyroid-carcinoma
#12
Surasawadee Ausavarat, Jiraporn Sriprapaporn, Busara Satayaban, Wanna Thongnoppakhun, Aunchalee Laipiriyakun, Boontham Amornkitticharoen, Rujaporn Chanachai, Chaveevan Pattanachak
BACKGROUND: Circulating thyrotropin receptor messenger ribonucleic acid (TSHR mRNA) assay has been validated in the follow-up of differentiated thyroid carcinoma (DTC) because of its high sensitivity during thyroid hormone therapy and no interference with endogenous anti-thyroglobulin antibodies (TgAb) compared to serum thyroglobulin (Tg). We investigated the efficacy of TSHR mRNA assay in 160 DTC patients using quantitative PCR (qPCR). FINDINGS: Only TSHR mRNA level of structural persistent disease with TgAb-positive (3...
2015: Thyroid Research
https://www.readbyqxmd.com/read/26157488/the-ratio-of-serum-free-triiodothyronine-to-free-thyroxine-in-children-a-retrospective-database-survey-of-healthy-short-individuals-and-patients-with-severe-thyroid-hypoplasia-or-central-hypothyroidism
#13
Yuji Oto, Koji Muroya, Junko Hanakawa, Yumi Asakura, Masanori Adachi
BACKGROUND: The ratio of serum free triiodothyronine (FT3) to free thyroxine (FT4) has been shown to be constant in healthy adults. However, this ratio has been found to be decreased in athyreotic adult patients on levothyroxine (L-T4) supplementation. In order to better evaluate thyroid-related pathologies in children as well as to establish a reference range, we investigated the FT3/FT4 ratio in a pediatric population. Furthermore, we evaluated this ratio in children with congenital hypothyroidism as well as those with central hypothyroidism...
2015: Thyroid Research
https://www.readbyqxmd.com/read/26157487/thyroid-hormones-and-functional-outcomes-after-ischemic-stroke
#14
Lena M O'Keefe, Sarah E Conway, Alexandra Czap, Carl D Malchoff, Sharon Benashski, Gilbert Fortunato, Ilene Staff, Louise D McCullough
BACKGROUND: Stroke is the fifth leading cause of death and the primary cause of long-term adult disability in the United States. Increasing evidence suggests that low T3 levels immediately following acute ischemic stroke are associated with greater stroke severity, higher mortality rates, and poorer functional outcomes. Prognosis is also poor in critically ill hospitalized patients who have non-thyroidal illness syndrome (NTIS), where T3 levels are low, but TSH is normal. However, data regarding the association between TSH levels and functional outcomes are contradictory...
2015: Thyroid Research
https://www.readbyqxmd.com/read/26146517/iodine-intake-as-a-risk-factor-for-thyroid-cancer-a-comprehensive-review-of-animal-and-human-studies
#15
Michael B Zimmermann, Valeria Galetti
Thyroid cancer (TC) is the most common endocrine malignancy and in most countries, incidence rates are increasing. Although differences in population iodine intake are a determinant of benign thyroid disorders, the role of iodine intake in TC remains uncertain. We review the evidence linking iodine intake and TC from animal studies, ecological studies of iodine intake and differentiated and undifferentiated TC, iodine intake and mortality from TC and occult TC at autopsy, as well as the case-control and cohort studies of TC and intake of seafood and milk products...
2015: Thyroid Research
https://www.readbyqxmd.com/read/26097507/low-bmi-and-low-tsh-value-as-risk-factors-related-to-lower-bone-mineral-density-in-postmenospausal-women-under-levothyroxine-therapy-for-differentiated-thyroid-carcinoma
#16
Thaís Gomes de Melo, Lígia Vera Montalli da Assumpção, Allan de Oliveira Santos, Denise Engelbrecht Zantut-Wittmann
OBJECTIVE: Treatment of differentiated thyroid carcinoma (DTC) includes suppression of TSH with levothyroxine therapy, which may negatively influence bone mineral density (BMD), but the effects are controversial. We aimed to evaluate the relationship between TSH-suppressive therapy and BMD in postmenopausal women with DTC. METHODOLOGY: Cross-sectional study that assessed BMD by densitometry and risk factors for decreased BMD in 109 postmenopausal women under TSH-suppressive therapy for DTC, compared to an age-matched euthyroid women control group...
2015: Thyroid Research
https://www.readbyqxmd.com/read/26000037/second-degree-av-block-and-severely-impaired-contractility-in-cardiac-myxedema-a-case-report
#17
Apostolos Chatzitomaris, Michael Scheeler, Michael Gotzmann, Roland Köditz, Janice Schildroth, Kathy Miriam Knyhala, Volkmar Nicolas, Christoph Heyer, Andreas Mügge, Harald H Klein, Johannes W Dietrich
The heart is a major target organ for thyroid hormone action. Severe overt hypothyroidism can result in diastolic hypertension, lowered cardiac output, impaired left ventricular contractility and diastolic relaxation, pericardial effusion and bradycardia. However, the function of the atrial pacemaker is usually normal and the degree by which the heart rate slows down is often modest. Here we report the case of a 20 year old male Caucasian with severe overt hypothyroidism. He presented with syncopation due to second degree atrioventricular block type Mobitz 2 and heart failure with reduced ejection fraction (38 %)...
2015: Thyroid Research
https://www.readbyqxmd.com/read/25908941/rare-thyroid-non-neoplastic-diseases
#18
Katarzyna Lacka, Adam Maciejewski
Rare diseases are usually defined as entities affecting less than 1 person per 2,000. About 7,000 different rare entities are distinguished and, among them, rare diseases of the thyroid gland. Although not frequent, they can be found in the everyday practice of endocrinologists and should be considered in differential diagnosis. Rare non-neoplastic thyroid diseases will be discussed. Congenital hypothyroidism's frequency is relatively high and its early treatment is of vital importance for neonatal psychomotor development; CH is caused primarily by thyroid dysgenesis (85%) or dyshormonogenesis (10-15%), although secondary defects - hypothalamic and pituitary - can also be found; up to 40% of cases diagnosed on neonatal screening are transient...
2015: Thyroid Research
https://www.readbyqxmd.com/read/25878727/hypothyroidism-and-brain-developmental-players
#19
R G Ahmed
Most of our knowledge on the mechanisms of thyroid hormone (TH) dependent brain development is based on clinical observations and animal studies of maternal/fetal hypothyroidism. THs play an essential role in brain development and hormone deficiency during critical phases in fetal life may lead to severe and permanent brain damage. Maternal hypothyroidism is considered the most common cause of fetal TH deficiency, but the problem may also arise in the fetus. In the case of congenital hypothyroidism due to defects in fetal thyroid gland development or hormone synthesis, clinical symptoms at birth are often mild as a result of compensatory maternal TH supply...
2015: Thyroid Research
https://www.readbyqxmd.com/read/25802554/metastatic-carcinoma-to-the-thyroid-gland-from-renal-cell-carcinoma-role-of-ultrasonography-in-preoperative-diagnosis
#20
Kaoru Kobayashi, Mitsuyoshi Hirokawa, Tomonori Yabuta, Mitsuhiro Fukushima, Hiroo Masuoka, Takuya Higashiyama, Minoru Kihara, Yasuhiro Ito, Akihiro Miya, Nobuyuki Amino, Akira Miyauchi
BACKGROUND: Patients with metastases to the thyroid from renal cell carcinoma (RCC) that need surgical management are not many and unfamiliar to clinicians and thyroid endocrinologists. Therefore, little information is available on ultrasonographic features of metastatic carcinoma in the thyroid. The strategic value of ultrasound in preoperative surgical planning for patients with thyroid nodules has become increasingly appreciated. The purposes of this article are to clarify the ultrasound characteristics of metastatic carcinoma to the thyroid from RCC by evaluating many patients in one institute, and to investigate the role of ultrasonography in preoperative diagnosis...
2015: Thyroid Research
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