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Current Radiopharmaceuticals

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https://www.readbyqxmd.com/read/30644351/comparison-between-18f-dopa-and-18f-fet-pet-ct-in-patients-with-suspicious-recurrent-high-grade-glioma-a-literature-review-and-our-experience
#1
Evangelista Laura, Cuppari Lea, Bellu Luisa, Bertin Daniele, Caccese Mario, Reccia Pasquale, Zagonel Vittorina, Lombardi Giuseppe
PURPOSES: The aims of the present study were to: 1- critical assess the utility of L-3,4-dihydroxy-6-18Ffluoro-phenyl-alanine (18F-DOPA) and O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET) positron emission tomography (PET)/computed tomography (CT) in patients with high grade glioma (HGG) and 2- describe the results of 18F-DOPA and 18F-FET PET/CT in a case series of patients with recurrent HGG. MATERIALS AND METHODS: We searched for studies using the following databases: PubMed, Web of Science and Scopus...
January 15, 2019: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/30636621/o%C3%A2-2%C3%A2-18f-%C3%A2-fluoroethyl-l%C3%A2-tyrosine-fet-in-neurooncology-a-review-of-experimental-results
#2
Carina Stegmayr, Antje Willuweit, Philipp Lohmann, Karl-Josef Langen
OBJECTIVES: In recent years, PET using radiolabelled amino acids has gained considerable interest as an additional tool besides MRI to improve the diagnosis of cerebral gliomas and brain metastases. A very successful tracer in this field is O-(2-[18F]fluoroethyl)-L-tyrosine (FET) which in recent years has replaced short lived tracers such as [11C]-methyl-L-methionine in many neuro-oncological centers in Western Europe. FET can be produced with high efficiency and distributed in a satellite concept like 2-[18F]fluoro-2-deoxy-D-glucose...
January 10, 2019: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/30636620/feasibility-and-evaluation-of-automated-methods-for-radiolabeling-of-radiopharmaceutical-kits-with-gallium-68
#3
Alban Revy, François Hallouard, Sandrine Joyeux-Klamber, Andrea Skanjeti, Catherine Rioufol, Marc Fraysse
OBJECTIVE: Recent gallium-68 labeled peptides are of increasing interest for PET imaging in nuclear medicine. Somakit TOC® is a radiopharmaceutical kit registered in the European Union for the preparation of [68Ga]Ga-DOTA-TOC used for the diagnosis of neuroendocrine tumors. Development of a labeling process using a synthesizer is particularly interesting for quality and reproducibility of the final product although only manual processes are described in the Summary of Product (SmPC) of the registered product...
January 10, 2019: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/30605068/-18f-amylovis-as-a-potential-pet-probe-for-%C3%AE-amyloid-plaque-synthesis-in-silico-in-vitro-and-in-vivo-evaluations
#4
Suchitil Rivera-Marrero, Laura Fernández-Maza, Samila León-Chaviano, Marquiza Sablón-Carrazana, Alberto Bencomo-Martónez, Alejandro Perera-Pintado, Anais Prats-Capote, Florencia Zoppolo, Ingrid Kreimerman, Tania Pardo, Laura Reyes, Marcin Balcerzyk, Geyla Dubed-Bandomo, Daymara Mercerón-Martónez, Luis A Espinosa-Rodróguez, Henry Engler, Eduardo Savio, Chryslaine Rodróguez-Tanty
BACKGROUND: Alzheimer's disease (AD) is the most common form of dementia. Neuroimaging methods have widened the horizons for AD diagnosis and therapy. The goals of this work are the following: i) the synthesis of 2-(3-fluoropropyl)-6-methoxynaphthalene (5) and its [18F]-radiolabeled counterpart ([18F]Amylovis), ii) the in silico and in vitro comparative evaluations of [18F]Amylovis and [11C]Pittsburg compound B (PIB) and iii) the in vivo preclinical evaluation of [18F]Amylovis in transgenic and wild mice...
January 2, 2019: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/30539709/-68ga-dota-peptide-pet-ct-in-neuroendocrine-tumors-main-clinical-applications
#5
Elisabetta Giovannini, Giampiero Giovacchini, Elisa Borsò, Patrizia Lazzeri, Mattia Riondato, Rossella Leoncini, Valerio Duce, Andrea Ciarmiello
OBJECTIVE: Neuroendocrine neoplasms (NENs) are generally defined as rare and heterogeneous tumors. The gastrointestinal system is the most frequent site of NENs localization, however they can be found in other anatomical regions, such as pancreas, lungs, ovaries, thyroid, pituitary, and adrenal glands. Neuroendocrine neoplasms have significant clinical manifestations depending on the production of active peptide. METHODS: Imaging modalities play a fundamental role in initial diagnosis as well as in staging and treatment monitoring of NENs, in particular they vastly enhanced the understanding of the physiopathology and diagnosis of NENs through the use of somatostatin analogue tracers labeled with appropriate radioisotopes...
December 11, 2018: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/30465520/utility-of-molecular-imaging-with-2-deoxy-2-fluorine-18-fluoro-d-glucose-positron-emission-tomography-18f-fdg-pet-for-small-cell-lung-cancer-sclc-a-radiation-oncology-perspective
#6
Omer Sager, Ferrat Dincoglan, Selcuk Demiral, Bora Uysal, Hakan Gamsiz, Yelda Elcim, Esin Gundem, Bahar Dirican, Murat Beyzadeoglu
BACKGROUND AND OBJECTIVE: Although accounting for a relatively small proportion of all lung cancers, small cell lung cancer (SCLC) remains to be a global health concern with grim prognosis. Radiotherapy (RT) plays a central role in SCLC management either as a curative or palliative therapeutic strategy. There has been considerable progress in RT of SCLC thanks to improved imaging techniques leading to accurate target localization for precise delivery of RT. Positron emission tomography (PET) is increasingly used in oncology practice as a non-invasive molecular imaging modality...
November 20, 2018: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/30465519/biochemical-and-histopathological-evaluation-of-the-radioprotective-effects-of-melatonin-against-gamma-ray-induced-skin-damage-in-rats
#7
Dheyauldeen Shabeeb, Masoud Najafi, Ahmed Eleojo Musa, Mansoor Keshavarz, Alireza Shirazi, Gholamreza Hassanzadeh, Mohammed Reza Hadian, Hedayat Samandari
BACKGROUND: Radiotherapy is one of the treatment methods for cancers using ionizing radiations. About 70% of cancer patients undergo radiotherapy. Radiation effect on the skin is one of the main complications of radiotherapy and dose limiting factor. To ameliorate this complication, we used melatonin as a radioprotective agent due to its antioxidant and anti-inflammatory effects, free radical scavenging, improving overall survival after irradiation as well as minimizing the degree of DNA damage and frequency of chromosomal abrasions...
November 20, 2018: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/30338747/synthesis-of-18f-faza-using-nosyl-and-iodo-precursors-for-nucleophilic-radiofluorination
#8
William Sun, Cheryl Falzon, Ebrahim Naimi, Ali Akbari, Leonard I Wiebe, Manju Tandon, Piyush Kumar
BACKGROUND: 1-α-D-(5-Deoxy-5-[18F]fluoroarabinofuranosyl)-2-nitroimidazole ([18F]FAZA) is manufactured by nucleophilic radiofluorination of 1-&alpha;-D-(2',3'-di-O-acetyl-5'-O-toluenesulfonylarabinofuranosyl)-2-nitroimidazole (DiAcTosAZA) and alkaline deprotection to afford [18F]FAZA. High yields (>60%) under optimized conditions frequently revert to low yields (<20%) in large scale, automated syntheses. Competing side reactions and concomitant complex reaction mixtures contribute to substantial loss of product during HPLC clean-up...
October 18, 2018: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/30215339/determination-of-gamma-camera-s-calibration-factors-for-quantitation-of-diagnostic-radionuclides-in-simultaneous-scattering-and-attenuation-correction
#9
Afrouz Asgari, Mansour Ashoor, Leila Sarkhosh, Abdollah Khorshidi, Parvaneh Shokrani
OBJECTIVE: The characterization of cancerous tissue and bone metastasis can be distinguished by the accurate assessment of accumulated uptake and activity from different radioisotopes. The various parameters and phenomena such as calibration factor, Compton scattering, attenuation and penetration are influenced intrinsic this quantity, and the qualification of images as well. METHODS: The camera calibration factor (CF) translates reconstructed count map into absolute activity map, is determined by both planar and tomographic scans using different phantom geometries...
September 13, 2018: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/30173659/evaluating-the-radioprotective-effect-of-curcumin-on-rat-s-heart-tissues
#10
Sedighe Kolivand, Peyman Amini, Hana Saffar, Saeed Rezapoor, Elahe Motevaseli, Masoud Najafi, Farzad Nouruzi, Dheyauldeen Shabeeb, Ahmed Eleojo Musa
BACKGROUND: Heart injury is one of the most important concerns after exposure to a high dose of radiation in chest cancer radiotherapy or whole body exposure to a radiation disaster. Studies have proposed that increased level of inflammatory and pro-fibrotic cytokines following radiotherapy or radiation events play a key role in the development of several side effects such as cardiovascular disorders. In current study, we aimed to evaluate the expression of IL-4 and IL-13 cytokines as well as signaling pathways such as IL4Ra1, IL13Ra2, Duox1 and Duox2...
August 30, 2018: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/30173658/dosimetry-and-toxicity-studies-of-the-novel-sulfonamide-derivative-of-sulforhodamine-101-18f-srf101-at-a-preclinical-level
#11
I Kreimerman, E Mora-Ramirez, A L Reyes, M Bardies, E Savio, H Engler
Background The SR101 N-(3-[18F]Fluoropropyl) sulfonamide ([18F]SRF101) is a Sulforhodamine 101 derivative that was previously synthesised by our group. The fluorescent dye SR101 has been reported as a marker of astroglia in the neocortex of rodents in vivo. Objective The aim of this study was to perform a toxicological evaluation of [18F]SRF101 and to estimate human radiation dosimetry based on preclinical studies. Methods Radiation dosimetry studies were conducted based on biokinetic data obtained from a mouse model...
August 30, 2018: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/30117406/choline-pet-ct-in-the-differential-diagnosis-between-cystic-glioblastoma-and-intraparenchymal-hemorrhage
#12
Pierpaolo Alongi, Ignazio Gaspare Vetrano, Elisa Fiasconaro, Valerio Alaimo, Riccardo Laudicella, Marina Bellavia, Francesca Rubino, Sergio Bagnato, Giuseppe Galardi
OBJECTIVE: Glioblastoma multiforme (GBM) represents the most common and malignant glioma, accounting for 45%-50% of all gliomas . The median survival time for patients with glioblastoma is only 12-15 months after surgical, chemioterapic and radiotherapic treatment; a correct diagnosis is naturally fundamental to establish a rapid and correct therapy. Non-invasive imaging plays a pivotal role in each phase of the diagnostic workup of patients with suspected for diagnosis. The aim of this case report was to describe the potential clinical impact of 18F-fluorocholine (FCH) PET/CT in the assessment of a cystic GBM mimicking a spontaneous hemorrhage...
August 17, 2018: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/30378473/the-evolving-clinical-role-of-actinium-225-and-bismuth-213-for-targeted-alpha-therapy-tat-production-radiopharmaceutical-development-and-clinical-applications
#13
EDITORIAL
Valery Radchenko, Paul Schaffer, F F Russ Knapp
No abstract text is available yet for this article.
2018: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/29972107/stability-study-of-18f-fludeoxyglucose-and-18f-fluorocholine-in-different-medical-devices-for-intravenous-administration
#14
F Hallouard, W Sauze, S Emery, A Skanjeti, C Rioufol, M Fraysse
OBJECTIVE: The present study had determine the impact of prolonged storage in a cartridge or syringe on the quality of the [18F]-radiopharmaceuticals used in our center [18F]fludeoxyglucose and [18F]fluorocholine). [18F]-radiopharmaceuticals registered as ready-to-use drugs are prepared in multidose flasks. When the change of packaging must be made extemporaneously for the preparation of patient unit doses in a syringe or cartridge, this is under the responsibility of radiopharmacists...
2018: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/29956640/final-outcome-of-223ra-therapy-and-the-role-of-18f-fluoride-pet-in-response-evaluation-in-metastatic-castration-resistant-prostate-cancer-a-single-institution-experience
#15
Kalevi Kairemo, Denai R Milton, Elba Etchebehere, Eric M Rohren, Homer A Macapinlac
BACKGROUND: 223Ra was the first therapeutic alpha-emitting radionuclide registered for clinical practice. This radionuclide is targeting actively bone-forming cells, and it is approved for treating metastatic skeletal disease in prostate cancer. 18F-PET is used to detect skeletal metastatic disease based on osteoblastic activity. The aim of this study was to analyze, if 18F-PET can be used assessing the results of 223Ra therapy, and to report final median overall survival in a total of 773 therapy cycles...
2018: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/29866026/-in-vivo-evaluation-of-225-ac-ac-dota-zol-for-%C3%AE-therapy-of-bone-metastases
#16
Nina Pfannkuchen, Nicole Bausbacher, Stefanie Pektor, Matthias Miederer, Frank Rosch
BACKGROUND: Conjugates of bisphosphonates with macrocyclic chelators possess high potential in bone targeted radionuclide imaging and therapy. DOTAZOL, zoledronic acid conjugated to DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), demonstrated promising results in vivo in small animals as well as in first patient applications using 68Ga for diagnosis via PET and the lowenergy β-emitter 177Lu for therapy of painful bone metastases. In consideration of the fact that targeted α-therapy probably offers various advantages over the use of β--emitters, the 225Ac-labelled derivative [225Ac]Ac-DOTAZOL was synthesized and evaluated in vivo...
2018: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/29807525/development-and-evaluation-of-liquid-and-solid-lipid-based-drug-delivery-systems-containing-technetium-99m-radiolabeled-alendronate-sodium
#17
Evren Gundogdu, Meliha Ekinci, Emre Ozgenc, Derya I Ozdemir, Makbule Asikoglu
OBJECTIVE: The purpose of this study was to develop lipid-water based drug delivery system of Alendronate Sodium (ALD) in liquid and solid form obtained by using spray drying method and compare these two forms with radioactive cell culture studies. METHODS: This study included the development of liquid and solid form obtained by spray drying method, radiolabelling of ALD with 99mTc, preparation of formulations containing 99mTc -ALD and evaluation of their permeability with Caco-2 cell...
2018: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/29804541/radioprotective-effect-of-cerium-oxide-nanoparticles-against-genotoxicity-induced-by-ionizing-radiation-on-human-lymphocytes
#18
Zohreh Zal, Arash Ghasemi, Shima Azizi, Hossein Asgarian-Omran, Azadeh Montazeri, Seyed Jalal Hosseinimehr
BACKGROUND: Ionizing radiation induces DNA damage on normal cell results in apoptosis and cell deaths. OBJECTIVES: The radioprotective effects of cerium oxide nanoparticles (CNPs) on genotoxicity, apoptosis and necrosis induced by Ionizing Radiation (IR) in human healthy lymphocytes as highly radiosensitive cells were investigated. MATERIALS AND METHODS: Lymphocytes were prepared from three volunteers and then treated with CNPs at different concentrations and exposed to IR at dose 1...
2018: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/29804540/pet-evaluation-of-late-cerebral-effect-in-advanced-radiation-therapy-techniques-for-cranial-base-tumors
#19
Pierpaolo Alongi, Leonardo Iaccarino, Marco Losa, Antonella Del Vecchio, Simonetta Gerevini, Valentina Plebani, Nadia Di Muzio, Pietro Mortini, Luigi Gianolli, Daniela Perani
BACKGROUND AND OBJECTIVE: Even though the benefits of radiation therapy are well established, it is important to recognize the broad spectrum of radiation-induced changes, particularly in the central nervous system. The possible damage to the brain parenchyma may have clinical consequences and in particular cognitive impairment might be one of the major complications of radiotherapy. To date, no studies have investigated the effects of focal radiation therapy on brain structure and function together with the assessment of their clinical outcomes at a long follow-up...
2018: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/29793418/clinical-studies-with-bismuth-213-and-actinium-225-for-hematologic-malignancies
#20
Joseph G Jurcic
OBJECTIVES: Due to the shorter range and higher linear energy transfer of α-particles compared to β-particles, targeted α-particle therapy may produce more efficient tumor killing while sparing neighboring healthy cells. We will review the clinical studies using α-particle therapy for Acute Myeloid Leukemia (AML). METHODS: A series of clinical trials were conducted to assess the safety, feasibility, and anti-leukemic effects of lintuzumab, an anti-CD33 humanized monoclonal antibody, labeled with the α-emitters bismuth- 213 (213Bi) and actinium-225 (225Ac)...
2018: Current Radiopharmaceuticals
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