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Current Radiopharmaceuticals

Mauro Liberatore, Giuseppe Gentile, Giulia Anna Follacchio, Viviana Frantellizzi, Giuseppe De Vincentis, Francesco Monteleone, Christos Anagnostou, Francesco Maria Drudi, Vittorio Calvisi
The aim of the present prospective study was to evaluate the usefulness of labeled leukocyte scan as a guide to open biopsy for the management of hip and knee prosthesis infection in patients without loosening of orthopedic device. Twenty-six patients with suspected hip (24) and knee (2) prosthesis infection underwent routine analysis of blood, plain radiography and 99m Tc-HMPAO labelled leukocyte scan (WBCS). On these basis, patients were subdivided in the following groups: bone infection without loosening (n°=14), septic loosening (n°=8), superficial infection (n°=2), no infection (n°=2)...
November 17, 2016: Current Radiopharmaceuticals
Lucia Martiniova, Louis De Palatis, Elba Etchebehere, Gregory Ravizzini
Over the past several years, Positron Emission Tomography (PET) imaging agents labeled with 68Gallium (68Ga) have undergone a significant increase in clinical utilization. 68Ga is conveniently produced from a germanium-68/gallium-68 (68Ge/68Ga) generator. Because of the compact size and ease of use of the generator, 68Ga labeled compounds may be more cost-effective than PET radioisotopes that are cyclotron-produced. The convenient half-life of 68Ga (T1/2=68 min) provides sufficient radioactivity for various PET imaging applications, while delivering acceptable radiation doses to patients...
October 28, 2016: Current Radiopharmaceuticals
Laura Evangelista, Maria Vittoria Dieci, Valentina Guarneri, Pier Franco Conte
PURPOSE: The aim of the study was to determine the correlation between 16α-18F-fluoro-17β-estradiol (18F-FES) uptake and the expression and functionality of estrogen receptors (ERs), as well as to evaluate the ability of 18F-FES PET to predict the response to hormonal therapy (HT) in patients with locally advanced or metastatic breast cancer (BC). METHODS: Literature searches in the major literature databases were carried out in order to select English-language articles dealing with 18F-FES PET and BC...
October 19, 2016: Current Radiopharmaceuticals
Ximena Camacho, Victoria Calzada, Marcelo Fernández, Omar Alonso, Roger Chammas, Eloisa Riva, Juan Pablo Gambini, Pablo Cabral
BACKGROUND: Vascular endothelial growth factor (VEGF) is one of the classic factors to tumor-induced angiogenesis in several types, including melanoma. Bevacizumab is a humanized monoclonal antibody directed against VEGF. OBJECTIVE: To radiolabel Bevacizumab with 177-Lutetium as a potential radioimmunotherapy agent for melanoma. METHODS: Bevacizumab was derivatized with DOTA-NHS-ester at 4 ºC for 18 h. DOTA-Bevacizumab was radiolabeled with 177LuCl3 (15 MBq/mg) at 37 ºC for 1 h...
October 10, 2016: Current Radiopharmaceuticals
Vahid Changizi, Atefeh Zamanian, Hasan Nedaie, Saeed Amanpour, Mahnaz Haddadi
PURPOSE: Gioblastoma multiforme as a chemoresistant and radioresistant malignant cell line needs to novel strategies to treatment. Low-dose hyper-radiosensitivity (LDHRS) seems to be an effective phenomenon to irradiation that can save normal brain fibroblasts. Genistein which is a soy isoflavone can be cytotoxic in some tumor cell lines. So we determined to study the effect of combining these two treatment modalities. MATERIALS AND METHODS: After 30 hours incubation with Genistein in different concentrations on U87MG cell line, proliferation and clonogenicity were conducted by both clonogenic and MTT assays...
August 13, 2016: Current Radiopharmaceuticals
Hong Yuan, Jonathan E Frank, Joseph R Merrill, Daniel A Hillesheim, Mark H Khachaturian, Atilio Anzellotti
The study aimed to develop the method of automated production on the hypoxia radiotracer 1-[18F]fluoro-3-(2-nitro-1H-imidazol-1-yl)-propan-2-ol ([18F]FMISO) on the novel fully automated platform of the BG75 system. Further validation of [18F]FMISO hypoxia imaging functionality in two tumor mouse models (FaDu/U87) was evaluated using PET/CT imaging, and the distribution of [18F]FMISO was validated by the standard hypoxia marker EF5. The average radiochemical purity was (99 ± 1) % and the average pH was 5.5 ± 0...
July 25, 2016: Current Radiopharmaceuticals
Fatma Yurt Lambrecht, Mine Ince, Ozge Er, Kasim Ocakoglu, Cagla Kayabasi, Cumhur Gunduz, Fatma Aslıhan Sarı
Pancreatic cancer is very common and difficult to diagnose in early stage. Imaging systems for diagnosing cancer have many disadvantages. However, combining different imaging modalities offer synergistic advantages. Optical imaging is the most multidirectional and widely used imaging modality in both clinical practice and research. In present study, Zinc(II) phthalocyanine [Zn(II)Pc] was synthesized, labeled with iodine-131 and in vitro study was carried out. The intracellular uptake studies of radiolabeled Zn(II)Pc were performed in WI-38 [ATCC CCL-75™, tissue: human fibroblast lung] and MIA PaCa-2 [ATCC CRL-1420™, tissue: human epithelial pancreas carcinoma] cell lines...
June 27, 2016: Current Radiopharmaceuticals
Pardeep Kumar, Ankit Watts, Pratap Acharya, Ranju Bansal, Anchal Ghai, Amritjyot Kaur, Baljinder Singh
This study describes the two steps method for radio synthesis of fluorine-18 [18F] labeled doxorubicin. A quaternary salt of the precursor pentamethylbenzyl-4-(trimethylammonium trifluoromethanesulfonate) benzoate was synthesized and characterized. As a first step, 4-[18F]-fluorobenzoic acid (FBA) was synthesized from precursor and used as an intermediate to label doxorubicin. In the second step, [18F]-FBA was attached to the primary amine of doxorubicin by acylation reaction. The total reaction time for the synthesis of [18F]-FBA-doxorubicin was about 60 minutes...
May 30, 2016: Current Radiopharmaceuticals
Francesco Bertagna, Domenico Albano, Giovanni Bosio, Arnoldo Piccardo, Bassam Dib, Raffaele Giubbini
BACKGROUND: 18F-FDG-PET/CT applications in the field of differentiated thyroid cancer (DTC) are continuously growing. OBJECTIVE: To retrospectively analyze in a wide population enrolled in two nuclear medicine centers the diagnostic value of 18F-FDG-PET/CT in patients treated with 131I and negative 131I-WBS but in presence of Tg levels higher than 1ng/ml after TSH stimulation. METHOD: From September 2005 to December 2014, 154 patients affected by DTC, treated with 131I with negative 131I-WBS and Tg≥1ng/ml underwent 18F-FDG-PET/CT...
May 23, 2016: Current Radiopharmaceuticals
Alireza Mirzaei, Amir R Jalilian, Mehdi Akhlaghi, Davood Beiki
INTRODUCTION: Gallium-68 citrate has been successfully applied in the PET imaging of infections and inflammation in some centers; however further evaluation of the tracer in inflammation models is of great importance. METHODS: 68Ga-citrate prepared from [68Ga]GaCl3 (eluted form an SnO2 based 68Ge/68Ga generator) and sodium citrate at optimized conditions followed by quality control tests was injected to normal and turpentine-oil induced rats PET/CT imaging studies up to 290 min...
May 6, 2016: Current Radiopharmaceuticals
Hong Yuan, Jonathan E Frank, Joseph R Merrill, Daniel A Hillesheim, Mark H Khachaturian, Atilio I Anzellotti
No abstract text is available yet for this article.
2016: Current Radiopharmaceuticals
Parul Thakral, Suhas Singla, Atul Vashist, Madhav P Yadav, Santosh K Gupta, Jaya S Tyagi, Atul Sharma, Chandra S Bal, EmptyYN Y Snehlata, Arun Malhotra
BACKGROUND AND OBJECTIVES: The aim of the study is to evaluate the therapeutic efficacy and safety of Yttrium- 90 radiolabelled chimeric anti CD20 antibody-Rituximab in the treatment of patients with relapsed/ refractory B cell Non-Hodgkins Lymphoma (NHL). METHODS: Twenty patients with relapsed/refractory CD20+ NHL in progressive state were included in the study. These patients had undergone a median of 2 (range 2-5) prior standard chemotherapy ± immunotherapy regimens...
2016: Current Radiopharmaceuticals
Stelvio Sestini, Rosanna Perone, Sandro Domenichetti, Christian Mazzeo, Veronica Massai, Alessandra Rispoli, Agnese Barbacci, Angela Valtancoli, Antonio Castagnoli, Luigi Mansi
PURPOSE: To assess changes in social and neuro-cognition and regional cerebral blood flow (rCBF) in schizophrenic patients with psychotic syndrome treated with Social Skill Training (SST). METHODS: 17 patients underwent two high resolution rCBF SPECT at rest before and after a one-year treatment with SST. Patients were assessed using a neuropsychological evaluation (W.A.I.S.-R, T.M.T, Verbal Fluency, W.C.S.T.). SPM8 was used to investigate rCBF changes from the pre- to the post-SST condition and the relationship between rCBF and clinical scores used as covariates of interest...
2016: Current Radiopharmaceuticals
Linnea Langhans, Thomas Levin Klausen, Tove Filtenborg Tvedskov, Ilse Vejborg, Niels Kroman, Birger Hesse
The majority of patients with nonpalpable breast lesions are eligible for breast conserving surgery guided by some kind of lesion localization. The current standard is wire-guided localization (WGL) even though it has several disadvantages, the most important one being the considerable proportion of patients with insufficient resection margin. These patients require a reoperation. New methods in the field of radioguided surgery (RGS) have been developed including radioguided occult lesion localization (ROLL) and radioactive seed localization (RSL)...
2016: Current Radiopharmaceuticals
María Elena Cardoso, Leticia Fernández, Emilia Tejería, Patricia Esperón, Mariella Terán
BACKGROUND AND OBJECTIVE: The design of target-specific molecular imaging probes to determine infection sites are mainly based on the biochemistry of the inflammatory response that may lead to an ideal agent for infection imaging. Infectious diseases timely and specifically diagnosed can be clinically challenging but essential for the patient's recovery. Laboratory tests can detect the responsible microorganism but cannot discriminate between sterile inflammatory disease and truly infectious disease...
2016: Current Radiopharmaceuticals
Ambikalmajan M R Pillai, Furn F Russ Knapp
No abstract text is available yet for this article.
2016: Current Radiopharmaceuticals
Sean L Kitson, Luigi Mansi
No abstract text is available yet for this article.
2016: Current Radiopharmaceuticals
Vincenzo Cuccurullo, Giuseppe D Di Stasio, Maria L Schillirò, Luigi Mansi
Due to different sizes of humans and rodents, the performance of clinical imaging devices is not enough for a scientifically reliable evaluation in mice and rats; therefore dedicated small-animal systems with a much higher sensitivity and spatial resolution, compared to the ones used in humans, are required. Smallanimal imaging represents a cutting-edge research method able to approach an enormous variety of pathologies in which animal models of disease may be used to elucidate the mechanisms underlying the human condition and/or to allow a translational pharmacological (or other) evaluation of therapeutic tools...
2016: Current Radiopharmaceuticals
Hishar Hassan, Suharzelim Abu Bakar, Khairul Najah Che A Halim, Jaleezah Idris, Fathinul Fikri Ahmad Saad, Abdul Jalil Nordin
BACKGROUND AND OBJECTIVE: 18F-Fluorocholine has been suggested as one of the reputable imaging tracers for diagnosis of prostate tumour in Positron Emission Tomography / Computed Tomography (PET/CT) modality. Nevertheless, it has never been synthesised in Malaysia. We acknowledged that the major problem with 18F-Fluorocholine is due to its relatively low radiochemical yield at the end of synthesis (EOS). Therefore, this article presents improved 18FFluorocholine radiochemical yields after carrying out optimisation on azeotropic drying of 18F-Fluorine...
2016: Current Radiopharmaceuticals
Linnea Langhans, Thomas Levin Klausen, Tove Filtenborg Tvedskov, Maj-Lis Talman, Peter Sandor Oturai, Ilse Vejborg, Niels Kroman, Birger Hesse
UNLABELLED: Radioactive seed localization (RSL) is a new technique for surgical identification of non-palpable breast lesions. We describe the preparation of the needle with I-125 seeds for ultrasound-guided deposition in breast lesions. In a feasibility study we investigated the minimum activity amount needed for reliable gamma probe identification of the seeds and the levels of exposure to the staff. METHODS: 11 patients received a seed, which was manually placed in an 18 gauge needle with bone wax occluding the tip, and the radiologist introduced it into the breast tissue guided by ultra-sound...
2016: Current Radiopharmaceuticals
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