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Current Radiopharmaceuticals

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https://www.readbyqxmd.com/read/29119942/18f-faza-pet-ct-in-the-preoperative-evaluation-of-nsclc-comparison-with-18f-fdg-and-immunohistochemistry
#1
Paola Mapelli, Valentino Bettinardi, Federico Fallanca, Elena Incerti, Antonia Compierchio, Francesca Rossetti, Angela Coliva, Annarita Savi, Claudio Doglioni, Giampiero Negri, Luigi Gianolli, Maria Picchio
PURPOSE: To assess the capability of 18F-FAZA PET/CT in identifying intratumoral hypoxic areas in early and locally advanced non-small cell lung cancer (NSCLC) patients and to compare 18F-FAZA PET/CT with 18F-FDG PET/CT and histopathological biomarkers and to investigate whether the assessment of tumour to blood (T/B) and tumour to muscle (T/M) ratios provides comparable information regarding the hypoxic fractions of the tumour. MATERIALS AND METHODS: Seven patients with NSCLC were prospectively enrolled (3 men, 4 women; median age: 71 years; range 63-80)...
November 8, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/29090673/pet-ct-with-68ga-psma-in-prostate-cancer-radiopharmaceutical-background-and-clinical-implications
#2
Giampiero Giovacchini, Elisabetta Giovannini, Mattia Riondato, Andrea Ciarmiello
In the last twenty years, positron emission tomography / computed tomography (PET/CT) with radiolabeled choline, represented the most powerful imaging modality for prostate cancer (PCa). However, the low positive detection rate of the technique for PSA < 1 ng/ml prompted the development of other tracers for imaging PCa. 68Ga-PSMA is a receptor ligand tracer, which has been identified as the most promising radiopharmaceutical for imaging PCa. The most promising feature of this radiopharmaceutical is the high positive detection rate for prostate specific antigen (PSA) levels < 1 ng/ml or less (i...
November 1, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28969583/italian-tailored-assessment-of-lung-indeterminate-accidental-nodule-by-proposing-a-segmental-pet-computed-tomography-s-pet-ct-rationale-and-study-design-of-a-retrospective-multicenter-trial
#3
Laura Evangelista, Marco Spadafora, Leonardo Pace, Luigi Mansi, Alberto Cuocolo
BACKGROUND: The Italian Tailored Assessment of Lung Indeterminate Accidental Nodule (ITALIAN) is a retrospective, multicenter trial designed to compare the diagnostic information provided by segmental positron emission tomography (PET)/computed tomography (CT) (s-PET/CT) with those of whole body (wb)-PET/CT in patients with single pulmonary nodules (SPN). This report describes the details and implications of the ITALIAN trial design. METHODS AND RESULTS: Between September 2016 and May 2017, 502 consecutive patients (302 men, mean age 67±12 years) with SPN undergoing 18F-fluorodeoxyglucose (FDG) PET/CT were enrolled...
October 2, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28956517/synthesis-of-18f-2b-srf101-a-sulfonamide-derivative-of-the-fluorescent-dye-sulforhodamine-101
#4
Ingrid Kreimerman, Williams Porcal, Patricia Oliver, Eduardo Savio, Henry Engler
Background The red fluorescent dye Sulforhodamine 101 (SR101) has been used in neuroscience research as a useful tool for staining of astrocytes, since it has been reported as a marker of astroglia in the neocortex of rodents in vivo. The aim of this work is to label SR101 with positron emission radionuclides, in order to provide a radiotracer to study its biological behaviour. This study is the first attempt to label SR101 with [18F], using a chemical derivatization via a sulfonamide-linker and a commercially available platform...
September 27, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28933270/11c-choline-pet-ct-based-helical-tomotherapy-as-treatment-approach-for-bone-metastases-in-recurrent-prostate-cancer-patients
#5
Elena Incerti, Vincenzo Gangemi, Paola Mapelli, Chiara Lucrezia Deantoni, Giampiero Giovacchini, Federico Fallanca, Andrei Fodor, Andrea Ciarmiello, Sergio Baldari, Luigi Gianolli, Nadia Di Muzio, Maria Picchio
To evaluate the efficacy of 11C-choline PET/CT (CHO-PET/CT) based helical tomotherapy (HTT) as a therapeutic approach for bone metastases in recurrent prostate cancer (PCa) patients. METHODS This retrospective study includes 20 PCa patients (median age: 67; range: 51-80 years) presenting biochemical relapse after primary treatment who underwent CHO-PET/CT based HTT on positive bone metastases from December 2007 to June 2014. The effectiveness of HTT assessed with biochemical response at 3/6/12 months, biochemical relapse free survival (bRFS) and overall survival (OS) at 2 years...
September 19, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28891436/radio-localization-of-non-palpable-breast-lesions-under-ultrasonographic-guidance-current-status-and-future-perspectives
#6
Giulia Anna Follacchio, Francesco Monteleone, Maria Letizia Meggiorini, Maria Paola Nusiner, Carlo De Felice, Giuseppe De Vincentis, Mauro Liberatore
BACKGROUND: Due to the spread of mammographic screening programs, a constant increase of clinically-occult breast cancer diagnosis has been registered. A correct approach to non-palpable breast lesions requires an accurate intra-operative localization in order to achieve a complete surgical resection. Aim of this paper is to describe the state of the art of the US-guided procedures such as Radio-guided Occult Lesion Localization (ROLL) and Radio-guided Seed Localization (RSL) in comparison to the most widely adopted Wire-Guided Localization (WGL)...
September 8, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28814253/pet-mr-tomographs-a-review-with-technical-radiochemical-and-clinical-perspectives
#7
Giampiero Giovacchini, Elisabetta Giovannini, Mattia Riondato, Andrea Ciarmiello
In the last decade, an increasing number of positron emission tomography / magnetic resonance (PET/MR) tomographs have been installed and many clinical studies were performed in the neurological field. Although PET/MR has many favorable properties to support the application in brain imaging, attenuation correction, and therefore accurate quantification, is a problem that still requires optimal solution. In this review we have summarized the three main methods that are currently used to correct for attenuation in PET/MR, namely atlas- or template-based methods, segmentation-based methods, and reconstruction-based methods...
August 16, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28814252/bone-imaging-in-metastatic-castration-resistant-prostate-cancer-where-do-we-stand
#8
Petros Sountoulides, Linda Metaxa
We are witnessing an era of increased clinical interest in metastatic castration-resistant prostate cancer, both in terms of treatment and also in terms of imaging options. This surge in interest is attributed to the recent developments in treatments for metastatic prostate cancer that are able to confer a significant survival advantage. We are therefore anticipating an increase in the number of patients that we will need to treat at this disease stage. Imaging is undoubtedly crucial in monitoring disease response to treatment and progression...
August 16, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28814251/the-role-of-radiopharmaceuticals-in-amiodarone-induced-thyroid-pathology
#9
Doina Piciu, Alexandru Irimie
Amiodarone is a di-iodinated benzofuran derivative and is classified as a class III antiarrhythmic agent. It is one of the most powerful and effective antiarrhythmics, being a first-line agent due to its ability to treat ventricular and supraventricular dysrhythmias; since 1960 the drug has become one of the most frequently prescribed antiarrhythmics, despite its potentially serious, side effects. By far, one of the most challenging condition is the thyroid pathology induced by this drug. Each 200 mg tablet of amiodarone contains approximately 75 mg of iodine, 3-10% from each tablet being released as free iodine...
August 16, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28758574/personalized-and-precision-medicine-in-cancer-a-theragnostic-approach
#10
Partha S Choudhury, Manoj Gupta
Background & objectives: There are many challenges in the execution of targeted therapy in cancer due to tumor heterogeneity between individuals. In case of solid tumors this is one of the reasons as to why genomic analysis from single tumor biopsy specimens underestimate the mutational burdens in such heterogenous tumors thus contributing to treatment failure and drug resistance. Molecular characteristics redefine tumor classification for molecular targeted therapies ensuring the best patient specific therapies with better specificity and cost effective ratio...
July 27, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28721805/automated-one-pot-radiosynthesis-of-11c-s-adenosyl-methionine
#11
Florencia Zoppolo, Williams Porcal, Patricia Oliver, Eduardo Osvaldo Savio, Henry Engler
BACKGROUND: Glycine-N-methyl transferase is an enzyme overexpressed in some neoplastic tissues. It catalyses the methylation of glycine using S-adenosyl methionine (SAM) as co-enzyme. SAM is involved in a great variety of biochemical processes, including transmethylation reactions. Thus, [11C]SAM could be used to evaluate transmethylation activity in tumours. The only method reported for [11C]SAM synthesis is an enzymatic process with several limitations. We propose a new chemical method to obtain [11C]SAM, through a one-pot synthesis...
July 18, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28714401/chemical-consequences-of-radioactive-decay-and-their-biological-implications
#12
Onofre T DeJesus
The chemical effects of radioactive decay arise from (1) transmutation, (2) formation of charged daughter nuclei, (3) recoil of the daughter nuclei, (4) electron "shakeoff" phenomenon and (5) vacancy cascade in decays via electron capture and internal conversion. This review aims to reiterate what has been known for a long time regarding the chemical consequences of radioactive decay and gives a historical perspective to the observations that led to their elucidation. The energetics of the recoil process in each decay mode is discussed in relation to the chemical bond between the decaying nucleus and the parent molecule...
July 14, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28681701/radiochemical-evaluation-and-in-vitro-assessment-of-the-targeting-ability-of-a-novel-99mtc-hynic-rgd-for-u87mg-human-brain-cancer-cells
#13
Hanieh Karimi, Nourollah Sadeghzadeh, Saeid Abediankenari, Farzaneh Rezazadeh, Fereshteh Hallajian
BACKGROUND: Labeled RGD peptide that specifically targets ανβ3 integrin has great potential for the early diagnosis of malignant tumors. αvβ3 integrin receptors appear specifically more on the surface of glioblastoma (malignant glioma) cells rather than normal cells. OBJECTIVE: The aim of this study was to identify a novel RGD that can be radiolabeled with 99mTc with in vitro assessment of its targeting ability for U87MG human brain cancer cells. METHOD: Novel RGD was designed by Amino Acid retro-inversion technique...
July 6, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28675994/effect-of-treatment-with-caspofungin-on-the-diagnosis-of-fungal-infections-by-gamma-scintigraphy
#14
L Fernández, A L Reyes, P Oliver, M Terán
The aim of this work is to assess the influence of treatment with unlabeled-Caspofungin, on the quality of diagnostic scintigraphic images of induced lesions in nude mice undergoing both bacterial and fungal infections and to determine the level of specificity of 99mTc-tricarbonyl-Caspofungin to discriminate between fungal or bacterial infections. In vitro studies on the behaviour of the 99mTc-tricarbonyl-Caspofungin complex binding percentage at different yeast concentrations of Candida albicans or Staphylococcus aureus were made...
July 3, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28637403/experiences-with-99mtc-hmpao-in-a-diagnostic-pathway-for-violent-patients-with-schizophrenic-spectrum-disorders
#15
Morten Jacobsen, Arvid Jensen, Guttorm Breivik Storvestre, Tone Marie Bergstrom, Diyar Nori Mohamad Rashi, Nielssen Bjorn, Wiktor Pal, Hymer Knut-Erik
Background and objective In a security ward we assessed the diagnostic contribution of single photon scintigraphy [SPECT] in our diagnostic pathway for patients with serious mental disease and a history of violence. Methods Twenty patients were examined between 2012 and 2015 and the findings compared to those in nine patients with the same diagnosis, but no history of violence. Results All violent patients had areas with reduced accumulation of 99mTc-HMPAO frontally and in the temporal lobe, in the non-violent group only two patients demonstrated these findings...
June 21, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28530534/biological-evaluation-of-99mtc-hynic-edda-tricine-ser-3-d4-peptide-for-tumor-targeting
#16
Ziba Kazemi, Mona Haddad Zahmatkesh, Seyed Mohammad Abedi, Seyed Jalal Hosseinimehr
BACKGROUND: D4 small peptide (Leu-Ala-Arg-Leu-Leu-Thr) was selected as an appropriate agent for specific targeting of epidermal growth factor receptor (EGFR). OBJECTIVE: The aim of study was to investigate the 99mTc-labeled D4 peptide for non small cell lung tumor targeting. METHOD: HYNIC-(Ser)3-D4 peptide was labeled with 99mTc using mixture of tricine and ethylenediamine diacetic acid (EDDA) as co-ligands. The in vitro cellular uptake of radiolabebled peptide was evaluated by blocking test on human non small lung cancer (A-549) cell line and its biodistribution was evaluated in A-549 xenografted nude mice...
May 19, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28530533/respiratory-motion-management-in-pet-ct-applications-and-clinical-usefulness
#17
Luca Guerra, Elena De Ponti, Sabrina Morzenti, Chiara Spadavecchia, Cinzia Crivellaro
Although breathing movement can introduce heavy bias in both image quality and quantitation, currently there is lack of interest for the respiratory motion management in PET/CT imaging. The respiratory gating technology has shown significant benefits on image quality, reducing motion related artifacts and increasing quantification. Indeed, many papers have demonstrated that there is a consistent increase of the Standardized Uptake Value (SUV) in gated PET images when compared to ungated ones, particularly for the small lesions located both in liver and in lung...
May 19, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28462719/intraoperative-localisation-of-impalpable-breast-lesions-utilising-the-rollis-technique-following-peritumoral-99mtc-colloid-sentinel-node-lymphoscintigraphy
#18
Te-Jui Hung, John Burrage, Anita Bourke, Donna Taylor
BACKGROUND: Ultrasound or stereotactic guided hook-wire localisation has been the standard-of-care for the pre-surgical localisation of impalpable breast lesions, which account for approximately a third of all breast cancer. Radioguided occult lesion localisation using I-125 seeds (ROLLIS) is a relatively new technique for guiding surgical excision of impalpable breast lesions, and is a promising alternative to the traditional hook-wire method. When combined with Tc-99m labelled colloid for sentinel node mapping in clinically indicated cases, there has been uncertainty regarding whether the downscatter of Tc-99m into the I-125 energy spectrum could adversely affect the intra-operative detection of the I-125 seed, especially pertaining to a peritumoral injection...
April 27, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28412923/fdg-pet-ct-predicts-outcome-in-oropharingeal-carcinoma-patients-undergoing-intensity-modulated-radiation-therapy-with-dose-escalation-to-fdg-avid-tumour-volumes
#19
Paola Mapelli, Sara Broggi, Elena Incerti, Pierpaolo Alongi, Margarita Kirienko, Claudio Fiorino, Italo Dell Oca, Federico Fallanca, Emilia Giovanna Vanoli, Nadia Gisella Di Muzio, Luigi Gianolli, Maria Picchio
PURPOSE: To evaluate the predictive value of FDG-PET/CT parameters on outcome of oropharyngeal squamocellular cancer (OSCC) patients undergoing helical tomotherapy (HTT), with dose escalation to FDG-PET/CT positive tumour volumes using the simultaneous integrated boost (SIB) technique. MATERIALS AND METHODS: We analysed 41 patients studied by FDG-PET/CT and treated with radical intent between 2005 and 2014 for OSCC. HTT-SIB was delivered in 30 fractions concomitantly: 69 Gy, as SIB, to the PET-positive volume (biological target volume - BTV-PET), both to the primary tumour (T) and lymph nodes (N), 66 Gy to the T and positive N, 54 Gy to the laterocervical nodes at risk...
April 13, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28332450/nuclear-medicine-in-patients-with-net-radiolabeled-somatostatin-analogues-and-their-brothers
#20
Vincenzo Cuccurullo, Maria Rosaria Prisco, Giuseppe Danilo Di Stasio, Luigi Mansi
Although Somastostatin (SS) scintigraphy (SRS) has been introduced many years ago, it remains the most diffuse radionuclide diagnostic tool in patients with neuroendocrine tumours (NETs). Being SS receptors (SSTR) expressed in the majority of NETs, radiolabeled SS analogues (SS-A) provide high diagnostic accuracy, mainly in patients with gastro-entero-pancreatic (GEP) tumors. SSTR are the best target for radiotracers used either for diagnostic and therapeutic purposes in NETs due to their presence on the surface of neoplastic cells of clinical interest...
March 23, 2017: Current Radiopharmaceuticals
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