journal
Journals Journal of Cardiovascular Tran...

Journal of Cardiovascular Translational Research

https://read.qxmd.com/read/38277087/the-role-of-ccta-derived-cardiac-structure-and-function-analysis-in-the-prediction-of-readmission-in-nonischemic-heart-failure
#21
JOURNAL ARTICLE
Chengjia Liu, Shuangxiang Lin, Yangyang Sheng, Xinghong Wang, Jianzhong Sun, Jiaxing Wu, Risheng Yu
Cardiac function and structure significantly impact nonischemic heart failure (HF) patient outcomes. This study investigated 236 patients (107 nonischemic heart failure, 129 healthy) to assess the relationship between coronary computed tomography angiography (CCTA)-derived parameters and clinical outcomes. Among the nonischemic heart failure patients, 37.3% experienced readmissions. In this group, specific CCTA measurements were identified as significant predictors of readmission: epicardial adipose tissue (CTEAT ) at 54...
January 26, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38270847/dysregulation-of-micro-rna-143-3p-as-a-biomarker-of-carotid-atherosclerosis-and-the-associated-immune-reactions-during-disease-progression
#22
JOURNAL ARTICLE
Paula González-López, Yinda Yu, Shiying Lin, Óscar Escribano, Almudena Gómez-Hernández, Anton Gisterå
Atherosclerosis commonly remains undiagnosed until disease manifestations occur. The disease is associated with dysregulated micro(mi)RNAs, but how this is linked to atherosclerosis-related immune reactions is largely unknown. A mouse model of carotid atherosclerosis, human APOB100-transgenic Ldlr-/- (HuBL), was used to study the spatiotemporal dysregulation of a set of miRNAs. Middle-aged HuBL mice with established atherosclerosis had decreased levels of miR-143-3p in their carotid arteries. In young HuBL mice, early atherosclerosis was observed in the carotid bifurcation, which had lower levels of miR-15a-5p, miR-143-3p, and miR-199a-3p, and higher levels of miR-155-5p...
January 25, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38240920/emerging-paradigms-in-atherosclerosis-the-impact-of-lncrna-psmb8-as1-on-vascular-inflammation-and-plaque-formation
#23
EDITORIAL
Xi-Long Zheng
No abstract text is available yet for this article.
January 19, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38231373/the-gut-microbiome-affects-atherosclerosis-by-regulating-reverse-cholesterol-transport
#24
REVIEW
Yangyang Jiang, Shuchao Pang, Xiaoyu Liu, Lixin Wang, Yi Liu
The human system's secret organ, the gut microbiome, has received considerable attention. Emerging research has yielded substantial scientific evidence indicating that changes in gut microbial composition and microbial metabolites may contribute to the development of atherosclerotic cardiovascular disease. The burden of cardiovascular disease on healthcare systems is exacerbated by atherosclerotic cardiovascular disease, which continues to be the leading cause of mortality globally. Reverse cholesterol transport is a powerful protective mechanism that effectively prevents excessive accumulation of cholesterol for atherosclerotic cardiovascular disease...
January 17, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38229002/camkii%C3%AE-stabilized-by-rna-n6-methyladenosine-reader-igf2bp2-boosts-coxsackievirus-b3-induced-myocardial-inflammation-via-interacting-with-tirap
#25
JOURNAL ARTICLE
Qingping Xiao, Lijuan Liu, Wei Qian, Ting Kang, Ru Ying, Jungang Nie
Calcium/calmodulin-dependent protein kinase II (CaMKII) has been demonstrated to be aberrantly activated in viral myocarditis (VMC), but the role of its subtype CaMKIIδ in VMC remains unclear.VMC mice and cardiomyocytes models were induced by Coxsackievirus B3 (CVB3) treatment. Mice that underwent sham surgery and saline-treated cardiomyocytes served as controls. Body weight, survival, left ventricular ejection fraction (LVEF), and fractional shortening (LVFS) were measured, and HE staining was performed to evaluate heart function in VMC mice model and sham control...
January 16, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38229001/automated-data-transformation-and-feature-extraction-for-oxygenation-sensitive-cardiovascular-magnetic-resonance-images
#26
JOURNAL ARTICLE
Glisant Plasa, Elizabeth Hillier, Judy Luu, Dominic Boutet, Mitchel Benovoy, Matthias G Friedrich
Oxygenation-sensitive cardiovascular magnetic resonance (OS-CMR) is a novel, powerful tool for assessing coronary function in vivo. The data extraction and analysis however are labor-intensive. The objective of this study was to provide an automated approach for the extraction, visualization, and biomarker selection of OS-CMR images. We created a Python-based tool to automate extraction and export of raw patient data, featuring 3336 attributes per participant, into a template compatible with common data analytics frameworks, including the functionality to select predictive features for the given disease state...
January 16, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38216830/the-role-of-branched-chain-amino-acids-and-their-metabolism-in-cardiovascular-diseases
#27
REVIEW
Zhiyu Li, Yibin Wang, Haipeng Sun
Branched-chain amino acids (BCAAs), including leucine, isoleucine, and valine, are essential amino acids for protein synthesis. Recent studies have yielded new insights into their diverse physiological and pathological roles in health and disease. Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality globally. An increasing number of clinical studies have demonstrated that high levels of circulating BCAAs are associated with an increased risk of CVDs. Animal studies have provided preliminary evidence linking BCAA intake and metabolism with cardiovascular diseases...
January 12, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38196010/postoperative-dipping-patterns-of-mean-arterial-pressure-and-mortality-after-coronary-artery-bypass-grafting
#28
JOURNAL ARTICLE
Bohao Jian, Haoliang Liu, Yi Zhang, Gang Li, Song Yang, Guangguo Fu, Suiqing Huang, Yang Huang, Zhuoming Zhou, Zhongkai Wu, Mengya Liang
Blood pressure dipping patterns have long been considered to be associated with adverse events. We aimed to investigate whether dipping patterns of postoperative MAP were related to 90-day and hospital mortality in patients undergoing CABG. Four thousand three hundred ninety-one patients were classified into extreme dippers (night-to-day ratio of MAP ≤ 0.8), dippers (0.8 < night-to-day ratio of MAP ≤ 0.9), non-dippers (0.9 < night-to-day ratio of MAP ≤ 1), and reverse dippers (> 1)...
January 9, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38180696/the-china-hypertrophic-cardiomyopathy-project-chcmp-the-rationale-and-design-of-a-multicenter-prospective-registry-cohort-study
#29
JOURNAL ARTICLE
Zhi Du, Kai Wang, Yawei Cui, Xudong Xie, Ruoyu Zhu, Fanghong Dong, Xiaogang Guo
Hypertrophic cardiomyopathy (HCM) is associated with adverse outcomes, such as heart failure, arrhythmia, and mortality. Sudden cardiac death (SCD) is a common cause of death in HCM patients, and identification of patients at a high risk of SCD is crucial in clinical practice. The China Hypertrophic Cardiomyopathy Project is a hospital-based, multicenter, prospective, registry cohort study of HCM patients, covering a total of 3000 participants and with a 5-year follow-up plan. A large number of demographic characteristics and clinical data will be fully collected to identify prognostic factors in Chinese HCM patients...
January 5, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38112908/absence-of-myocardial-involvement-after-sars-cov-2-vaccination-in-asymptomatic-adolescents
#30
JOURNAL ARTICLE
Rocío Párraga, Carlos Real, Inés García-Lunar, Gonzalo Pizarro, Javier Sánchez-González, Raquel Diaz-Munoz, Ernesto González-Calvo, Juan Miguel Fernandez-Alvira, Jesús Martínez-Gómez, Rodrigo Fernández-Jiménez
This study aimed to evaluate the presence of subclinical myocardial damage in adolescents who were vaccinated against SARS-CoV-2. One hundred twenty asymptomatic adolescents with a mean age of 16.0 ± 0.4 years (51% girls) underwent cardiac magnetic resonance (CMR) imaging. SARS-CoV-2 IgG/IgM antibody testing was performed, and self-reported dates of confirmed SARS-CoV-2 infection and/or vaccination were collected. Participants were classified according to SARS-CoV-2 status as naïve (non-infected and unvaccinated, n = 74), infected (unvaccinated, n = 23), and vaccinated (independently of past infection status, n = 23)...
December 19, 2023: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38092988/cav1-protein-encapsulated-in-mouse-bmsc-derived-extracellular-vesicles-alleviates-myocardial-fibrosis-following-myocardial-infarction-by-blocking-the-tgf-%C3%AE-1-smad2-c-jun-axis
#31
JOURNAL ARTICLE
Yijin Wu, Wenying Peng, Siyao Chen, Xiaodong Zeng, Jiade Zhu, Ping Zhu
Extracellular vesicles (EVs) derived from mouse bone marrow mesenchymal stem cells (mBMSCs) convey the CAV1 protein, influencing the TGF-β1/SMAD2/c-JUN pathway and thus the molecular mechanisms underlying myocardial fibrosis (MF) post-myocardial infarction (MI). Through various experimental methods, including transmission electron microscopy, Nanosight analysis, Western blot, ELISA, and qRT-PCR, we isolated, purified, and identified EVs originating from mBMSCs. Bioinformatics and experimental findings show a reduced expression of CAV1 in myocardial fibrosis tissue...
December 13, 2023: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38092987/non-coding-rna-mediated-gene-regulation-in-cardiovascular-disorders-current-insights-and-future-directions
#32
REVIEW
Muhammad Abubakar, Mohsin Hajjaj, Zil E Zehra Naqvi, Hameed Shanawaz, Ammara Naeem, Suraj Sai Nikhil Padakanti, Christopher Bellitieri, Rajasekar Ramar, Fenil Gandhi, Ayesha Saleem, Abul Hasan Shadali Abdul Khader, Muhammad Ahmad Faraz
Cardiovascular diseases (CVDs) pose a significant burden on global health. Developing effective diagnostic, therapeutic, and prognostic indicators for CVDs is critical. This narrative review explores the role of select non-coding RNAs (ncRNAs) and provides an in-depth exploration of the roles of miRNAs, lncRNAs, and circRNAs in different aspects of CVDs, offering insights into their mechanisms and potential clinical implications. The review also sheds light on the diverse functions of ncRNAs, including their modulation of gene expression, epigenetic modifications, and signaling pathways...
December 13, 2023: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38091232/diabetes-mellitus-to-accelerated-atherosclerosis-shared-cellular-and-molecular-mechanisms-in-glucose-and-lipid-metabolism
#33
REVIEW
Nan Zhao, Xiaoting Yu, Xinxin Zhu, Yanting Song, Fei Gao, Baoqi Yu, Aijuan Qu
Diabetes is one of the critical independent risk factors for the progression of cardiovascular disease, and the underlying mechanism regarding this association remains poorly understood. Hence, it is urgent to decipher the fundamental pathophysiology and consequently provide new insights into the identification of innovative therapeutic targets for diabetic atherosclerosis. It is now appreciated that different cell types are heavily involved in the progress of diabetic atherosclerosis, including endothelial cells, macrophages, vascular smooth muscle cells, dependence on altered metabolic pathways, intracellular lipids, and high glucose...
December 13, 2023: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38066358/correction-new-insights-into-the-genetics-of-cardiomyopathies
#34
Roddy Walsh
No abstract text is available yet for this article.
December 8, 2023: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38064044/alk1-deficiency-impairs-the-wound-healing-process-and-increases-mortality-in-murine-model-of-myocardial-infarction
#35
JOURNAL ARTICLE
Shreyas Bhave, Lija Swain, Xiaoying Qiao, Gregory Martin, Tejasvi Aryaputra, Kay Everett, Navin K Kapur
The functional role of TGFβ type I receptor, activin-like kinase (ALK)-1 in post-myocardial infarction (MI) cardiac remodeling is unknown. We hypothesize that reduced ALK1 activity reduces survival and promotes cardiac fibrosis after MI. MI was induced in wild-type (WT), and ALK+/- mice by left coronary ligation. After 14 days ALK1+/- mice had reduced survival with a higher rate of cardiac rupture compared to WT mice. ALK1+/- left ventricles (LVs) had increased volumes at the end of systole and at the end of diastole...
December 8, 2023: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38062335/t-cell-immunoglobulin-and-mucin-domain-3-in-circulating-monocytes-as-a-novel-biomarker-for-coronary-artery-disease
#36
JOURNAL ARTICLE
Fangping Xiao, Zhiqiang Jia, Lei Wang, Meng Liu, Xiaoxiao Chen, Zhan Gu, Yizhou Chen, Yi Li, Mingyue Chen, Mei Hong
The diagnostic role of T-cell immunoglobulin and mucin domain 3 (Tim-3) expression levels in circulating monocytes in coronary artery disease (CAD) remains to be determined. Here, we enrolled of 265 patients and isolated circulating monocytes from the blood of all participants. We found that the Tim-3 expression levels in monocytes were lower in CAD patients than in the control group. Spearman correlation analysis verified that the Tim-3 levels in monocytes were negatively correlated with the Gensini score and the number of coronary vessels...
December 7, 2023: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38038868/rna-sequencing-of-whole-blood-in-premature-coronary-artery-disease-identification-of-novel-biomarkers-and-involvement-of-t-cell-imbalance
#37
JOURNAL ARTICLE
Si Chen, Zhan Li, Haolong Li, Xiaoli Zeng, Hui Yuan, Yongzhe Li
Serum biomarkers were explored based on the peripheral blood gene expression profiles of premature coronary artery disease (PCAD). RNA sequencing (RNA-Seq) was used to detect PCAD-specific differentially expressed genes (DEGs). Quantitative real-time polymerase chain reaction (RT-PCR) was used to validate the most significant DEGs, and enzyme-linked immunosorbent assay (ELISA) was utilized to quantify the effect on corresponding serum proteins. Fifty-nine PCAD-specific DEGs were identified. Functional analysis showed positive regulation of T cell-mediated cytotoxicity, regulation of T cell-mediated immunity, and the regulation of alpha-beta T cell proliferation which were enriched in PCAD...
December 1, 2023: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/37477868/age-and-sex-differences-in-the-genetics-of-cardiomyopathy
#38
JOURNAL ARTICLE
Oyediran Akinrinade, Robert Lesurf, Jane Lougheed, Tapas Mondal, John Smythe, Luis Altamirano-Diaz, Erwin Oechslin, Seema Mital
Cardiomyopathy has variable penetrance. We analyzed age and sex-related genetic differences in 1,397 cardiomyopathy patients (Ontario, UK) with whole genome sequencing. Pediatric cases (n = 471) harbored more deleterious protein-coding variants in Tier 1 cardiomyopathy genes compared to adults (n = 926) (34.6% vs 25.9% respectively, p = 0.0015), with variant enrichment in constrained coding regions. Pediatric patients had a higher burden of sarcomere and lower burden of channelopathy gene variants compared to adults...
December 2023: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38019448/the-trouble-with-trabeculation-how-genetics-can-help-to-unravel-a-complex-and-controversial-phenotype
#39
REVIEW
Roddy Walsh
Excessive trabeculation of the cardiac left ventricular wall is a complex phenotypic substrate associated with various physiological and pathological processes. There has been considerable conjecture as to whether hypertrabeculation contributes to disease and whether left ventricular non-compaction (LVNC) cardiomyopathy is a distinct pathology. Building on recent insights into the genetic basis of LVNC cardiomyopathy, in particular three meta-analysis studies exploring genotype-phenotype associations using different methodologies, this review examines how genetic research can advance our understanding of trabeculation...
November 29, 2023: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38015357/new-insights-into-the-genetics-of-cardiomyopathies
#40
EDITORIAL
Roddy Walsh
No abstract text is available yet for this article.
November 28, 2023: Journal of Cardiovascular Translational Research
journal
journal
41906
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.