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Journal of Cardiovascular Translational Research

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https://www.readbyqxmd.com/read/30324254/stem-cell-homing-a-potential-therapeutic-strategy-unproven-for-treatment-of-myocardial-injury
#1
Zhonghao Tao, Shihua Tan, Wen Chen, Xin Chen
Despite advances in the prevention and therapeutic modalities of ischemic heart disease, morbidity and mortality post-infarction heart failure remain big challenges in modern society. Stem cell therapy is emerging as a promising therapeutic strategy. Stem cell homing, the ability of stem cells to find their destination, is receiving more attention. Identification of specific cues and understanding the signaling pathways that direct stem cells to targeted destination will improve stem cell homing efficiency...
October 15, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/30315504/does-no-touch-technique-better-than-conventional-or-intermediate-saphenous-vein-harvest-techniques-for-coronary-artery-bypass-graft-surgery-a-systematic-review-and-meta-analysis
#2
Abdelrahman Elshafay, Ahmed Hesham Bendary, Huan Thanh Vuong, Ahmed Reda Ahmed, Mohamed Ashraf Mokhtar, Ali Lotfy Soliman, Nguyen Lam Vuong, Israa Atia El Bestawi, Nirmeen Atef Abdallah, Vi Tuong Vu, Kenji Hirayama, Nguyen Tien Huy
Saphenous vein (SV) is a common graft being used in coronary artery bypass grafting (CABG). Conventional (CON), intermediate (I), and no-touch (NT) are the most common harvesting techniques of SV for CABG. The aim of this study is to systematically review the NT versus CON and I techniques in harvesting SV for CABG. Twelve databases were searched for randomized controlled trials comparing the CON, I, and NT techniques in harvesting SV for CABG. Twelve reports of six RCTs were included. Our meta-analysis showed that with NT technique, patency rate was significantly higher when compared to I technique up to 18-month follow-up duration...
October 12, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/30315503/a-simple-modified-framingham-scoring-system-to-predict-obstructive-coronary-artery-disease
#3
Yong Liu, Qiang Li, Shiqun Chen, Xia Wang, Yingling Zhou, Ning Tan, Jiyan Chen
Development of simple non-invasive risk prediction model would help in early prediction of coronary artery disease (CAD) reducing the burden on public health. This paper demonstrates a risk prediction scoring system to predict obstructive coronary artery disease (OCAD) in CAD patients. A total of 13,082 patients, referred for coronary angiography (CAG) in TRUST trial, were included in the development of a multivariable diagnostic prediction model. External validation of the model used 1009 patients from PRECOMIN study...
October 12, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/30302743/interleukin-1-receptor-like-1-il1r1-levels-are-not-increased-in-healthy-centenarians
#4
LETTER
Lourdes Vicent, Helena Martínez-Sellés, Alejandro Lucia, Enzo Emanuele, Francisco Fernández-Avilés, Manuel Martínez-Sellés
No abstract text is available yet for this article.
October 9, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/30302742/effect-of-long-term-exercise-training-on-lncrnas-expression-in-the-vascular-injury-of-insulin-resistance
#5
Suixin Liu, Fan Zheng, Ying Cai, Wenliang Zhang, Yaoshan Dun
LncRNA microarray analysis was applied to investigate the exercise effect on the global differential expressions of lncRNA and mRNA in aorta endothelium in insulin resistance. Twenty-four male C57BL/6 J mice were randomly divided into three groups: control group (n = 8), high-fat diet group (n = 8), and high-fat diet plus exercise training group (n = 8). An lncRNA microarray analysis was applied to investigate the global differential expressions of lncRNA and mRNA in aorta endothelium among three groups and the results were further verified by qPCR...
October 9, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/30276618/impact-of-neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio-on-5-year-clinical-outcomes-of-patients-with-stable-coronary-artery-disease-undergoing-elective-percutaneous-coronary-intervention
#6
Edoardo Bressi, Fabio Mangiacapra, Elisabetta Ricottini, Ilaria Cavallari, Iginio Colaiori, Giuseppe Di Gioia, Antonio Creta, Marialessia Capuano, Michele Mattia Viscusi, Germano Di Sciascio
The prognostic role of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with stable coronary artery disease (CAD) is still unclear. We enrolled 500 patients undergoing elective percutaneous coronary intervention (PCI). Blood samples were drawn prior to PCI for NLR and PLR calculation. Major adverse clinical events (MACE), which included death, myocardial infarction (MI), and target vessel revascularization (TVR), were recorded up to 5 years. Patients in the higher tertile of NLR presented higher Kaplan-Meier estimates of MACE (26...
October 1, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/30276617/transplantation-of-cardiac-mesenchymal-stem-cell-derived-exosomes-for-angiogenesis
#7
Chengwei Ju, Youngjun Li, Yan Shen, Yutao Liu, Jingwen Cai, Naifeng Liu, Gengshan Ma, Yaoliang Tang
We demonstrated the effects of exosomes secreted by cardiac mesenchymal stem cells (C-MSC-Exo) in protecting acute ischemic myocardium from reperfusion injury. To investigate the effect of exosomes from C-MSC on angiogenesis, we injected C-MSC-Exo or PBS intramuscularly into ischemic hind limb. Blood perfusion of limb was evaluated by laser Doppler Imaging. We observed that ischemic limb treated with C-MSC-Exo exhibits improved blood perfusion compared to ischemic limb treated with PBS at 2 weeks and 1 month after induction of limb ischemia...
October 1, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/30267328/concept-evaluation-and-future-perspectives-of-perkat%C3%A2-rv-a-novel-right-ventricular-assist-device
#8
REVIEW
Daniel Kretzschmar, P Christian Schulze, Markus W Ferrari
Right heart failure (RHF) is a life-threatening condition. Mechanical right heart support offers an option for critically ill patients. The PERKAT® RV device is designed for percutaneous implantation in acute RHF. It consists of a nitinol chamber covered by foils containing inflow valves. An outlet tube is attached to its distal tip. Using an 18F sheath, it is implanted in the inferior vena cava while the tube bypasses the right heart with its tip in the pulmonary trunk. Then, an IABP balloon is inserted in the pump chamber...
September 28, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/30251220/the-use-of-serum-mmp-9-and-timp-1-in-acute-coronary-syndrome
#9
LETTER
Laura Lahdentausta, Timo Sorsa, Erkki Pesonen, Pirkko Pussinen
No abstract text is available yet for this article.
September 24, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/30251219/the-exosome-a-new-player-in-diabetic-cardiomyopathy
#10
Lichan Tao, Jia Shi, Xiaoyu Yang, Ling Yang, Fei Hua
Diabetic cardiomyopathy (DCM) or diabetes-induced cardiac dysfunction is a direct consequence of uncontrolled metabolic syndrome and occurs worldwide. However, the underlying cellular and molecular mechanisms remain poorly understood. Recently, exosomes have attracted considerable interest for their use as efficient, targeted, and non-immunogenic delivery systems for biological molecules or pharmacotherapies. This review will summarize the fast-developing field of the regulation and function of exosomes in DCM, affording valuable insights and therapeutic opportunities in combatting diabetes-related cardiac disorder for modern human health...
September 24, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/30232730/aerobic-exercise-prevents-insulin-resistance-through-the-regulation-of-mir-492-resistin-axis-in-aortic-endothelium
#11
Ying Cai, Kang-Ling Xie, Fan Zheng, Sui-Xin Liu
Previously, we found that miR-492 delayed the progression of atherosclerosis (AS) by acting as an up-stream regulator of resistin. Therefore, we hypothesized that the anti-atherogenic effects of exercise are related to miR-492-mediated downregulation of resistin and repair of endothelial injury. In this study, we investigated the effects of the miR-492/resistin axis on improving endothelial injury in ApoE-/- mice (ApoE-deficient/knockout in C57BL/6 mice) through swimming exercises. Our results showed that the severity of AS and insulin resistance (IR) in these mice were significantly reduced by swimming exercises...
September 19, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/30232729/transplantation-of-cardiac-mesenchymal-stem-cell-derived-exosomes-promotes-repair-in-ischemic-myocardium
#12
Chengwei Ju, Yan Shen, Gengshan Ma, Yutao Liu, Jingwen Cai, Il-Man Kim, Neal L Weintraub, Naifeng Liu, Yaoliang Tang
Our previous study demonstrated the beneficial effects of exosomes secreted by cardiac mesenchymal stem cells (C-MSC-Exo) in protecting acute ischemic myocardium from reperfusion injury. Here, we investigated the effect of exosomes from C-MSC on angiogenesis in ischemic myocardium. We intramyocardially injected C-MSC-Exo or PBS into the infarct border zone after induction of acute mouse myocardial infarction (MI). We observed that hearts treated with C-MSC-Exo exhibit improved cardiac function compared to control hearts treated with PBS at one month after MI...
September 19, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/30173401/new-insights-into-the-role-of-exosomes-in-the-heart-after-myocardial-infarction
#13
Na Li, Luc Rochette, Yongxin Wu, Nathalie Rosenblatt-Velin
Intercellular communications play a pivotal role in several cardiac pathophysiological processes. One subtype of extracellular vesicles, so-called exosomes, became known as important intercellular communication mediators in the heart. Exosomes are lipid bilayer biological nanovesicles loaded with diverse proteins, lipids, and mRNAs/microRNAs. All major cardiac cell types can modulate recipient cellular function via the release of exosomes. After myocardial infarction (MI), exosomes, especially those secreted by different cardiac stem cells, have been shown to confer cardioprotective effects, activate regenerative signals, and participate into cardiac repair...
September 2, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/30171598/noncoding-rnas-in-cardiac-hypertrophy
#14
REVIEW
Yongqin Li, Yajun Liang, Yujiao Zhu, Yuhui Zhang, Yihua Bei
Cardiac hypertrophy is classified as pathological and physiological hypertrophy. Pathological hypertrophy typically precedes the onset of heart failure, one of the largest contributors to disease burden and deaths worldwide. In contrast, physiological hypertrophy is an adaptive response and protects against adverse cardiac remodeling. Noncoding RNAs (ncRNAs) have drawn significant attention over the last couple of decades, and their dysregulation is increasingly being linked to cardiac hypertrophy and cardiovascular diseases...
August 31, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/30155598/exosome-derived-dystrophin-from-allograft-myogenic-progenitors-improves-cardiac-function-in-duchenne-muscular-dystrophic-mice
#15
Xuan Su, Yue Jin, Yan Shen, Chengwei Ju, Jingwen Cai, Yutao Liu, Il-Man Kim, Yu Wang, Hong Yu, Neal L Weintraub, Meng Jiang, Yaoliang Tang
Progressive cardiomyocyte loss in Duchenne muscular dystrophy (DMD) leads to cardiac fibrosis, cardiomyopathy, and eventually heart failure. In the present study, we observed that myogenic progenitor cells (MPC) carry mRNA for the dystrophin gene. We tested whether cardiac function can be improved in DMD by allograft transplantation of MPC-derived exosomes (MPC-Exo) into the heart to restore dystrophin protein expression. Exo from C2C12 cells (an MPC cell line) or vehicle were delivered locally into the hearts of MDX mice...
August 28, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/30132237/serum-or-plasma-matrix-metalloproteinase-mmp-9-levels-and-cardiovascular-diseases
#16
LETTER
Indiara V Santana, Jose E Tanus-Santos
No abstract text is available yet for this article.
August 21, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/30105605/development-of-a-novel-human-cell-derived-tissue-engineered-heart-valve-for-transcatheter-aortic-valve-replacement-an-in-vitro-and-in-vivo-feasibility-study
#17
V Lintas, E S Fioretta, S E Motta, P E Dijkman, M Pensalfini, E Mazza, E Caliskan, H Rodriguez, M Lipiski, M Sauer, N Cesarovic, S P Hoerstrup, M Y Emmert
Transcatheter aortic valve replacement (TAVR) is being extended to younger patients. However, TAVR-compatible bioprostheses are based on xenogeneic materials with limited durability. Off-the-shelf tissue-engineered heart valves (TEHVs) with remodeling capacity may overcome the shortcomings of current TAVR devices. Here, we develop for the first time a TEHV for TAVR, based on human cell-derived extracellular matrix and integrated into a state-of-the-art stent for TAVR. The TEHVs, characterized by a dense acellular collagenous matrix, demonstrated in vitro functionality under aortic pressure conditions (n = 4)...
August 13, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/30084076/mechanical-unloading-by-fulminant-myocarditis-lv-impella-ecmella-bi-pella-and-propella-concepts
#18
Carsten Tschöpe, Sophie Van Linthout, Oliver Klein, Thomas Mairinger, Florian Krackhardt, Evgenij V Potapov, Gunther Schmidt, Daniel Burkhoff, Burkert Pieske, Frank Spillmann
Mechanical circulatory support (MCS) is often required to stabilize patients with acute fulminant myocarditis with cardiogenic shock. This review gives an overview of the successful use of left-sided Impella in the setting of fulminant myocarditis and cardiogenic shock as the sole means of MCS as well as in combination with right ventricular (RV) support devices including extracorporeal life support (ECLS) (ECMELLA) or an Impella RP (BI-PELLA). It further provides evidence from endomyocardial biopsies that in addition to giving adequate support, LV unloading by Impella exhibits disease-modifying effects important for myocardial recovery (i...
August 6, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/30073540/mirabegron-a-clinically-approved-%C3%AE-3-adrenergic-receptor-agonist-does-not-reduce-infarct-size-in-a-swine-model-of-reperfused-myocardial-infarction
#19
Xavier Rossello, Antonio Piñero, Rodrigo Fernández-Jiménez, Javier Sánchez-González, Gonzalo Pizarro, Carlos Galán-Arriola, Manuel Lobo-Gonzalez, Jean Paul Vilchez, Jaime García-Prieto, Jose Manuel García-Ruiz, Ana García-Álvarez, David Sanz-Rosa, Borja Ibanez
The administration of the selective β3 adrenergic receptor (β3AR) agonist BRL-37344 protects from myocardial ischemia/reperfusion injury (IRI), although the lack of clinical approval limits its translatability. We tested the cardioprotective effect of mirabegron, the first-in-class β3AR agonist approved for human use. A dose-response study was conducted in 6 pigs to select the highest intravenous dose of mirabegron without significant detrimental hemodynamic effect. Subsequently, closed chest anterior myocardial infarction (45 min ischemia followed by reperfusion) was performed in 26 pigs which randomly received either mirabegron (10 μg/kg) or placebo 5 min before reperfusion...
August 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/30039437/study-of-serum-cd147-level-in-patients-with-transient-ischemic-attack-and-cd147-expression-in-atherosclerotic-plaque
#20
Bin Xu, Chan Wu, Wenqing Wu, Yanguo Tan, Nannan Sun, Jian Cui, Siyu Lu, Jing Wang, Shan Cen
There is growing evidence that highlighted the potential effects of CD147 in atherosclerosis, but the potential implication of CD147 in diagnosis and treatment of transient ischemic attack (TIA) and acute cerebral infarction (ACI) is still unclear. In this work, we investigated the serum level of CD147 in patients with TIA and ACI, and CD147 expression in atherosclerotic plaque. The result showed significantly increasing serum level of CD147 in patients with TIA and ACI, and increasing amount of CD147 in vulnerable plaque compared with that in migrating plaque...
August 2018: Journal of Cardiovascular Translational Research
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