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Journal of Cardiovascular Translational Research

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https://www.readbyqxmd.com/read/28550590/exome-sequencing-identifies-candidate-genetic-modifiers-of-syndromic-and-familial-thoracic-aortic-aneurysm-severity
#1
Benjamin J Landis, Jeffrey A Schubert, Dongbing Lai, Anil G Jegga, Amy R Shikany, Tatiana Foroud, Stephanie M Ware, Robert B Hinton
Thoracic aortic aneurysm (TAA) is a genetic disease predisposing to aortic dissection. It is important to identify the genetic modifiers controlling penetrance and expressivity to improve clinical prognostication. Exome sequencing was performed in 27 subjects with syndromic or familial TAA presenting with extreme phenotypes (15 with severe TAA; 12 with mild or absent TAA). Family-based analysis of a subset of the cohort identified variants, genes, and pathways segregating with TAA severity among three families...
May 26, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28500574/tissue-engineering-bridging-the-gap
#2
EDITORIAL
Adrian H Chester
No abstract text is available yet for this article.
May 12, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28497301/various-regulatory-modes-for-circadian-rhythmicity-and-sexual-dimorphism-in-the-non-neuronal-cardiac-cholinergic-system
#3
Shino Oikawa, Yuko Kai, Asuka Mano, Hisayuki Ohata, Takahiro Nemoto, Yoshihiko Kakinuma
Cardiomyocytes possess a non-neuronal cardiac cholinergic system (NNCCS) regulated by a positive feedback system; however, its other regulatory mechanisms remain to be elucidated, which include the epigenetic control or regulation by the female sex steroid, estrogen. Here, the NNCCS was shown to possess a circadian rhythm; its activity was upregulated in the light-off phase via histone acetyltransferase (HAT) activity and downregulated in the light-on phase. Disrupting the circadian rhythm altered the physiological choline acetyltransferase (ChAT) expression pattern...
May 11, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28474304/the-notch-ligands-dll1-and-periostin-are-associated-with-symptom-severity-and-diastolic-function-in-dilated-cardiomyopathy
#4
Hilde M Norum, Kaspar Broch, Annika E Michelsen, Ida G Lunde, Tove Lekva, Aurelija Abraityte, Christen P Dahl, Arnt E Fiane, Arne K Andreassen, Geir Christensen, Svend Aakhus, Pål Aukrust, Lars Gullestad, Thor Ueland
In dilated cardiomyopathy (DCM), adverse myocardial remodeling is essential, potentially involving Notch signaling. We hypothesized that secreted Notch ligands would be dysregulated in DCM. We measured plasma levels of the canonical Delta-like Notch ligand 1 (DLL1) and non-canonical Notch ligands Delta-like 1 homologue (DLK1) and periostin (POSN) in 102 DCM patients and 32 matched controls. Myocardial mRNA and protein levels of DLL1, DLK1, and POSN were measured in 25 explanted hearts. Our main findings were: (i) Circulating levels of DLL1 and POSN were higher in patients with severe DCM and correlated with the degree of diastolic dysfunction and (ii) right ventricular tissue expressions of DLL1, DLK1, and POSN were oppositely associated with cardiac function indices, as high DLL1 and DLK1 expression corresponded to more preserved and high POSN expression to more deteriorated cardiac function...
May 4, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28462436/development-and-characterization-of-a-porcine-mitral-valve-scaffold-for-tissue-engineering
#5
M Granados, L Morticelli, S Andriopoulou, P Kalozoumis, M Pflaum, P Iablonskii, B Glasmacher, M Harder, J Hegermann, C Wrede, I Tudorache, S Cebotari, A Hilfiker, A Haverich, Sotirios Korossis
Decellularized scaffolds represent a promising alternative for mitral valve (MV) replacement. This work developed and characterized a protocol for the decellularization of whole MVs. Porcine MVs were decellularized with 0.5% (w/v) SDS and 0.5% (w/v) SD and sterilized with 0.1% (v/v) PAA. Decellularized samples were seeded with human foreskin fibroblasts and human adipose-derived stem cells to investigate cellular repopulation and infiltration, and with human colony-forming endothelial cells to investigate collagen IV formation...
May 1, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28432533/erratum-to-deep-phenotyping-of-systemic-arterial-hemodynamics-in-hfpef-part-1-physiologic-and-technical-considerations
#6
Julio A Chirinos
No abstract text is available yet for this article.
April 21, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28425039/disaggregation-following-agonist-induced-platelet-activation-in-patients-on-dual-antiplatelet-therapy
#7
Patricia P Wadowski, Beate Eichelberger, Christoph W Kopp, Joseph Pultar, Daniela Seidinger, Renate Koppensteiner, Irene M Lang, Simon Panzer, Thomas Gremmel
Disaggregation as the difference between maximal and final platelet aggregation by light transmission aggregometry indicates the stability of platelet aggregates. We evaluated the extent of disaggregation after platelet stimulation with adenosine diphosphate (ADP), arachidonic acid (AA), collagen, epinephrine, and thrombin receptor-activating peptide (TRAP)-6 in 323 patients on dual antiplatelet therapy with daily aspirin and clopidogrel (group 1), prasugrel (group 2), or ticagrelor (group 3) therapy. All patients in group 1 underwent elective angioplasty and stenting, whereas all patients included in groups 2 and 3 suffered from acute coronary syndromes (STEMI or NSTEMI) and underwent urgent PCI...
April 19, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28401511/deep-phenotyping-of-systemic-arterial-hemodynamics-in-hfpef-part-2-clinical-and-therapeutic-considerations
#8
Julio A Chirinos
Multiple phase III trials over the last few decades have failed to demonstrate a clear benefit of various pharmacologic interventions in heart failure with a preserved left ventricular (LV) ejection fraction (HFpEF). Therefore, a better understanding of its pathophysiology is important. An accompanying review describes key technical and physiologic aspects regarding the deep phenotyping of arterial hemodynamics in HFpEF. This review deals with the potential of this approach to enhance our clinical, translational, and therapeutic approach to HFpEF...
April 11, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28397162/sustained-placental-growth-factor-2-treatment-does-not-aggravate-advanced-atherosclerosis-in-ischemic-cardiomyopathy
#9
Ming Wu, Peter Pokreisz, Melissa Swinnen, Ellen Caluwe, Hilde Gillijns, Nina Vanden Driessche, Andrea Casazza, Erik Verbeken, Desire Collen, Stefan Janssens
Angiogenic growth factor therapy for ischemic cardiovascular disease carries a risk of stimulating atherosclerotic plaque growth. We evaluated risk benefit ratio of sustained administration of recombinant human placental growth factor (rhPlGF)-2 in mice with advanced atherosclerosis and chronic ischemic cardiomyopathy. We maintained apolipoprotein E-deficient mice on a high cholesterol diet and induced myocardial infarction by transient ligation at 4 weeks. At 8 weeks, we assessed left ventricular (LV) function and randomized mice to receive rhPlGF-2 or vehicle (VEH) subcutaneously for 28 days...
April 10, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28382580/the-dynamics-of-cardiovascular-biomarkers-in-non-elite-marathon-runners
#10
Emma Roca, Lexa Nescolarde, Josep Lupón, Jaume Barallat, James L Januzzi, Peter Liu, M Cruz Pastor, Antoni Bayes-Genis
The number of recreational/non-elite athletes participating in marathons is increasing, but data regarding impact of endurance exercise on cardiovascular health are conflicting. This study evaluated 79 recreational athletes of the 2016 Barcelona Marathon (72% men; mean age 39 ± 6 years; 71% ≥35 years). Blood samples were collected at baseline (24-48 h before the race), immediately after the race (1-2 h after the race), and 48-h post-race. Amino-terminal pro-B type natriuretic peptide (NT-proBNP, a marker of myocardial strain), ST2 (a marker of extracellular matrix remodeling and fibrosis, inflammation, and myocardial strain), and high-sensitivity troponin T (hs-TnT, a marker of myocyte stress/injury) were assayed...
April 5, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28364193/radiofrequency-ablation-of-the-atherosclerotic-plaque-a-proof-of-concept-study-in-an-atherosclerotic-model
#11
Guilielmus H J M Ellenbroek, Gerardus P J van Hout, Saskia C A de Jager, Leo Timmers, Aryan Vink, Roel Goldschmeding, Petra van der Kraak, Gerard Pasterkamp, Imo E Hoefer, Petrus A Doevendans, Yolande Appelman
Increased plaque vascularization is causatively associated with the progression of unstable atherosclerotic vessel disease. We investigated the safety and efficacy of heat-generating radiofrequency ablation (RFA) in reducing the number of vessels in the plaque and adventitia and its effect on plaque size and composition. To this end, New Zealand White rabbits were fed a cholesterol-enriched diet and subjected to balloon denudation of the infrarenal aorta to induce atherosclerotic plaque formation. After 13 weeks, the proximal or distal half of the infrarenal aorta was exposed to transluminal RFA...
March 31, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28289983/stem-cell-spheroids-and-ex-vivo-niche-modeling-rationalization-and-scaling-up
#12
REVIEW
Isotta Chimenti, Diana Massai, Umberto Morbiducci, Antonio Paolo Beltrami, Maurizio Pesce, Elisa Messina
Improved protocols/devices for in vitro culture of 3D cell spheroids may provide essential cues for proper growth and differentiation of stem/progenitor cells (S/PCs) in their niche, allowing preservation of specific features, such as multi-lineage potential and paracrine activity. Several platforms have been employed to replicate these conditions and to generate S/PC spheroids for therapeutic applications. However, they incompletely reproduce the niche environment, with partial loss of its highly regulated network, with additional hurdles in the field of cardiac biology, due to debated resident S/PCs therapeutic potential and clinical translation...
March 13, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28281243/mimicking-cardiac-fibrosis-in-a-dish-fibroblast-density-rather-than-collagen-density-weakens-cardiomyocyte-function
#13
Ariane C C van Spreeuwel, Noortje A M Bax, Bastiaan J van Nierop, Annemieke Aartsma-Rus, Marie-José T H Goumans, Carlijn V C Bouten
Cardiac fibrosis is one of the most devastating effects of cardiac disease. Current in vitro models of cardiac fibrosis do not sufficiently mimic the complex in vivo environment of the cardiomyocyte. We determined the local composition and mechanical properties of the myocardium in established mouse models of genetic and acquired fibrosis and tested the effect of myocardial composition on cardiomyocyte contractility in vitro by systematically manipulating the number of fibroblasts and collagen concentration in a platform of engineered cardiac microtissues...
March 9, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28281242/regulation-of-a-kinase-anchoring-protein-12-by-heat-shock-protein-a12b-to-prevent-ventricular-dysfunction-following-acute-myocardial-infarction-in-diabetic-rats
#14
Vaithinathan Selvaraju, Sumanth C Suresh, Mahesh Thirunavukkarasu, Jayakanthan Mannu, Jocelyn L C Foye, Premendu P Mathur, J Alexander Palesty, Juan A Sanchez, David W McFadden, Nilanjana Maulik
We examined the effects of overexpressing HSPA12B on angiogenesis and myocardial function by intramyocardial administration of adenovirus encoding HSPA12B (Ad. HSPA12B) in a streptozotocin-induced diabetic rat subjected to myocardial infarction. Rats were divided randomly into six groups: control sham (CS) + Ad.LacZ, control myocardial infarction (CMI) + Ad.LacZ, control MI + Ad.HSPA12B, diabetic sham (DS) + Ad.LacZ, diabetic MI + Ad.LacZ and diabetic MI + Ad.HSPA12B. Following MI or sham surgery, the respective groups received either Ad...
March 9, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28281241/decellularized-cryopreserved-allografts-as-off-the-shelf-allogeneic-alternative-for-heart-valve-replacement-in-vitro-assessment-before-clinical-translation
#15
Laura Iop, Adolfo Paolin, Paola Aguiari, Diletta Trojan, Elisa Cogliati, Gino Gerosa
Cryopreserved allogeneic conduits are the elective biocompatible choice among currently available substitutes for surgical replacement in end-stage valvulopathy. However, degeneration occurs in 15 years in adults or faster in children, due to recipient's immunological reactions to donor's antigens. Here, human aortic valves were decellularized by TRICOL, based on Triton X-100 and sodium cholate, and submitted to standard cryopreservation (TRICOL-human aortic valves (hAVs)). Tissue samples were analyzed to study the effects of the combined procedure on original valve architecture and donor's cell removal...
March 9, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28281240/translational-challenges-in-cardiovascular-tissue-engineering
#16
Maximilian Y Emmert, Emanuela S Fioretta, Simon P Hoerstrup
Valvular heart disease and congenital heart defects represent a major cause of death around the globe. Although current therapy strategies have rapidly evolved over the decades and are nowadays safe, effective, and applicable to many affected patients, the currently used artificial prostheses are still suboptimal. They do not promote regeneration, physiological remodeling, or growth (particularly important aspects for children) as their native counterparts. This results in the continuous degeneration and subsequent failure of these prostheses which is often associated with an increased morbidity and mortality as well as the need for multiple re-interventions...
March 9, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28265882/cardiovascular-bio-engineering-current-state-of-the-art
#17
REVIEW
Teresa Simon-Yarza, Isabelle Bataille, Didier Letourneur
Despite the introduction of new drugs and innovative devices contributing in the last years to improve patients' quality of life, morbidity and mortality from cardiovascular diseases remain high. There is an urgent need for addressing the underlying problem of the loss of cardiac or vascular tissues and therefore developing new therapies. Autologous vascular transplants are often limited by poor quality of donor sites and heart organ transplantation by donor shortage. Vascular and cardiac tissue engineering, whose aim is to repair or replace cardiovascular tissues by the use of cells, engineering and materials, as well as biochemical and physicochemical factors, appears in this scenario as a promising tool to repair the damaged hearts and vessels...
March 6, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28258421/phenomapping-for-the-identification-of-hypertensive-patients-with-the-myocardial-substrate-for-heart-failure-with-preserved-ejection-fraction
#18
Daniel H Katz, Rahul C Deo, Frank G Aguilar, Senthil Selvaraj, Eva E Martinez, Lauren Beussink-Nelson, Kwang-Youn A Kim, Jie Peng, Marguerite R Irvin, Hemant Tiwari, D C Rao, Donna K Arnett, Sanjiv J Shah
We sought to evaluate whether unbiased machine learning of dense phenotypic data ("phenomapping") could identify distinct hypertension subgroups that are associated with the myocardial substrate (i.e., abnormal cardiac mechanics) for heart failure with preserved ejection fraction (HFpEF). In the HyperGEN study, a population- and family-based study of hypertension, we studied 1273 hypertensive patients utilizing clinical, laboratory, and conventional echocardiographic phenotyping of the study participants. We used machine learning analysis of 47 continuous phenotypic variables to identify mutually exclusive groups constituting a novel classification of hypertension...
March 3, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28097523/intravascular-ultrasound-characterization-of-a-tissue-engineered-vascular-graft-in-an-ovine-model
#19
Victoria K Pepper, Elizabeth S Clark, Cameron A Best, Ekene A Onwuka, Tadahisa Sugiura, Eric D Heuer, Lilamarie E Moko, Shinka Miyamoto, Hideki Miyachi, Darren P Berman, Sharon L Cheatham, Joanne L Chisolm, Toshiharu Shinoka, Christopher K Breuer, John P Cheatham
Patients who undergo implantation of a tissue-engineered vascular graft (TEVG) for congenital cardiac anomalies are monitored with echocardiography, followed by magnetic resonance imaging or angiography when indicated. While these methods provide data regarding the lumen, minimal information regarding neotissue formation is obtained. Intravascular ultrasound (IVUS) has previously been used in a variety of conditions to evaluate the vessel wall. The purpose of this study was to evaluate the utility of IVUS for evaluation of TEVGs in our ovine model...
April 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28213846/fixation-of-bovine-pericardium-based-tissue-biomaterial-with-irreversible-chemistry-improves-biochemical-and-biomechanical-properties
#20
H Tam, W Zhang, D Infante, N Parchment, M Sacks, N Vyavahare
Bioprosthetic heart valves (BHVs), derived from glutaraldehyde crosslinked (GLUT) porcine aortic valve leaflets or bovine pericardium (BP), are used to replace defective heart valves. However, valve failure can occur within 12-15 years due to calcification and/or progressive structural degeneration. We present a novel fabrication method that utilizes carbodiimide, neomycin trisulfate, and pentagalloyl glucose crosslinking chemistry (TRI) to better stabilize the extracellular matrix of BP. We demonstrate that TRI-treated BP is more compliant than GLUT-treated BP...
February 17, 2017: Journal of Cardiovascular Translational Research
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