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Journal of Cardiovascular Translational Research

Ying-Jia Xu, Zhang-Sheng Wang, Chen-Xi Yang, Ruo-Min Di, Qi Qiao, Xiu-Mei Li, Jia-Ning Gu, Xiao-Juan Guo, Yi-Qing Yang
Dilated cardiomyopathy (DCM) is the most prevalent cause of non-ischemic cardiac failure and the commonest indication for cardiac transplantation. Compelling evidence highlights the pivotal roles of genetic defects in the occurrence of DCM. Nevertheless, the genetic determinants underpinning DCM remain largely obscure. In this study, the coding regions of ISL1, which encodes a transcription factor critical for embryonic cardiogenesis and postnatal cardiac remodeling, were sequenced in 216 unrelated patients with DCM, and a novel heterozygous ISL1 mutation, NM_002202...
December 10, 2018: Journal of Cardiovascular Translational Research
Yihua Bei, Chao Shi, Zhongrong Zhang, Junjie Xiao
As the most populous country worldwide, China has ≈ 290 million patients with cardiovascular diseases (CVDs), representing the leading cause of death in Chinese population. The morbidity and mortality of CVDs are continuously rising. Here, we will first summarize the recent advance in the management of CVDs such as coronary arterial disease, arrhythmia, and heart failure in China. In particular, we will introduce the development of chest pain centers and indicate the novel techniques and methods applied for the management of CVDs...
December 7, 2018: Journal of Cardiovascular Translational Research
Valeria Raparelli, Marco Proietti, Andrea Lenzi, Stefania Basili
Improvements in ischemic heart disease (IHD) management have been unbalanced between sexes, with coronary microvascular dysfunction considered the likely underlying reason. The Endocrine Vascular disease Approach (EVA) is an observational study ( NCT02737982) aiming to assess sex and gender interactions between coronary circulation, sexual hormones, and platelet function. Consecutive patients with IHD undergoing coronary angiography will be recruited: (1) to assess sex and gender differences in angiographic reperfusion indexes; (2) to evaluate the effects of estrogen/androgen on sex-related differences in myocardial ischemia; (3) to investigate the platelet biology differences between men and women with IHD; (4) to verify sex- and gender-driven interplay between response to percutaneous coronary intervention, platelets, sex hormones, and myocardial damage at baseline and its impact on 12-month outcomes...
December 3, 2018: Journal of Cardiovascular Translational Research
Yang Liu, Zhuyuan Liu, Yuan Xie, Cuimei Zhao, Jiahong Xu
Extracellular vesicles (EVs) are small-sized membrane-surrounded structures released from cells into the blood, which play important roles in regulating various biological processes. However, the role of EVs in Doxorubicin (DOX)-induced cardiomyocytes senescence remains elusive. In this study, we found that human serum EVs inhibited DOX-induced senescence in H9C2 cells, which was abolished by miR-34a mimic. Our study also proved that miR-34a mediated DOX-induced H9C2 cell senescence by targeting phosphatase 1 nuclear targeting subunit (PNUTS)...
November 29, 2018: Journal of Cardiovascular Translational Research
Ayeeshik Kole, Yingchun Cao, Jie Hui, Islam A Bolad, Mouhamad Alloosh, Ji-Xin Cheng, Michael Sturek
Intravascular photoacoustic-ultrasound (IVPA-US) imaging and near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) are two hybrid modalities that detect arterial lipid, with comparison necessary to understand the relative advantages of each. We performed in vivo and ex vivo IVPA-US imaging of the iliac arteries of Ossabaw swine with metabolic syndrome (MetS) and lean swine to investigate sensitivity for early-stage atherosclerosis. We repeated imaging ex vivo with NIRS-IVUS for comparison to IVPA-US and histology...
November 28, 2018: Journal of Cardiovascular Translational Research
Jenny Seilitz, Tal M Hörer, Per Skoog, Mitra Sadeghi, Kjell Jansson, Birger Axelsson, Kristofer F Nilsson
The impact of acute cardiac dysfunction on the gastrointestinal tract was investigated in anesthetized and instrumented pigs by sequential reductions of cardiac output (CO). Using a cardiac tamponade (n = 6) or partial inferior caval vein balloon inflation (n = 6), CO was controllably reduced for 1 h each to 75% (CO75% ), 50% (CO50% ), and 35% (CO35% ) of the baseline value. Cardiac output in controls (n = 6) was not manipulated and maintained. Mean arterial pressure, superior mesenteric arterial blood flow, and intestinal mucosal perfusion started to decrease at CO50% in the intervention groups...
November 19, 2018: Journal of Cardiovascular Translational Research
Janita A Maring, Kirsten Lodder, Emma Mol, Vera Verhage, Karien C Wiesmeijer, Calinda K E Dingenouts, Asja T Moerkamp, Janine C Deddens, Pieter Vader, Anke M Smits, Joost P G Sluijter, Marie-José Goumans
Cell transplantation studies have shown that injection of progenitor cells can improve cardiac function after myocardial infarction (MI). Transplantation of human cardiac progenitor cells (hCPCs) results in an increased ejection fraction, but survival and integration are low. Therefore, paracrine factors including extracellular vesicles (EVs) are likely to contribute to the beneficial effects. We investigated the contribution of EVs by transplanting hCPCs with reduced EV secretion. Interestingly, these hCPCs were unable to reduce infarct size post-MI...
November 19, 2018: Journal of Cardiovascular Translational Research
Tinen L Iles, Stephen G Quallich, Paul A Iaizzo
Radiofrequency, a common ablation modality, is used clinically to terminate cardiac arrhythmias. With excessive heating, complications sometimes occur when the applied energy generates steam pops, which cause release of energy in the form of tissue and/or air emboli. In this study, we investigated numerous parameters potentially associated with intracardiac steam pops including (1) wattage, (2) catheter tip temperature, (3) catheter irrigation, (4) anatomic site, and (5) repeat ablations at a given site. Using unique Visible Heart® methodologies in reanimated swine hearts, we visualized 539 ablations; steam pops developed in 140 of these ablations...
November 14, 2018: Journal of Cardiovascular Translational Research
Loretta Zsuzsa Kiss, Zsolt Bagyura, Csaba Csobay-Novák, Árpád Lux, Lívia Polgár, Ádám Jermendy, Pál Soós, Zsolt Szelid, Pál Maurovich-Horvat, Dávid Becker, Béla Merkely
Detecting early-stage atherosclerosis is an important step towards cardiovascular disease prevention. Coronary artery calcium (CAC) score is a sensitive and non-invasive tool for detecting coronary atherosclerosis. Higher serum uric acid (SUA) levels are known to be associated with cardiovascular diseases. However, there is inconsistency regarding the independence of the association. The aim of our study was to assess the association of CAC and SUA in an asymptomatic population. CAC scans of 281 participants were analyzed in a voluntary screening program...
November 9, 2018: Journal of Cardiovascular Translational Research
Wen Pan, Yujiao Zhu, Xiangmin Meng, Chenlin Zhang, Yan Yang, Yihua Bei
Exosomes are important carriers of biological information that facilitate intercellular communication and participate in the pathophysiology of different cardiovascular diseases. Myocardial infarction is among the leading causes of death worldwide. Upon myocardial infarction, massive cardiomyocyte death triggers a strong inflammatory response which is a vital process of cardiac injury, repair, and remodeling. Increasing evidence has unveiled that exosomes are involved in the inflammatory response and immune regulation after myocardial infarction...
October 29, 2018: Journal of Cardiovascular Translational Research
Belay Tesfamariam
Bioresorbable scaffolds have emerged as a potential alternative to non-erodible metal implants to alleviate the long-term risk of permanent device vascular implant-related adverse events. Bioresorbable scaffolds provide a temporary mechanical support function until the vessel reaches complete healing, and the implant progressively disappears and vasomotion resumes. A polymer matrix with embedded drugs coated onto the scaffold surface degrades slowly, reducing the size from the exterior toward the interior, and this allows controlled drug release to a local vascular segment...
October 26, 2018: Journal of Cardiovascular Translational Research
Rickard P F Lindblom, Qiujin Shen, Sofie Axén, Ulf Landegren, Masood Kamali-Moghaddam, Stefan Thelin
Surgery on the arch or descending aorta is associated with significant risk of neurological complications. As a consequence of intubation and sedation, early neurologic injury may remain unnoticed. Biomarkers to aid in the initial diagnostics could prove of great value as immediate intervention is critical. Twenty-three patients operated in the thoracic aorta with significant risk of perioperative neurological injury were included. Cerebrospinal fluid (CSF) and serum were obtained preoperatively and in the first and second postoperative days and assessed with a panel of 92 neurological-related proteins...
October 26, 2018: Journal of Cardiovascular Translational Research
Rosa M Agra-Bermejo, Rocio Gonzalez-Ferreiro, J Nicolos Lopez-Canoa, Alfonso Varela-Roman, Ines Gomez-Otero, Sonia Eiras, José R González-Juanatey
A obesity paradox has been described following heart failure (HF). The aim of this study was to analyze the association between food intake-involved adipokines and long-term weight changes. Leptin, adiponectin, and omentin were analyzed in 92 acute HF (AHF) patients at discharge, classified on the basis of weight gains or losses > 6%. The mean follow-up was 256 ± 143 days. Leptin and adiponectin levels were similar among weight groups. However, omentin levels were higher in those patients who had gained weight (16 ± 5 ng/mL) than in those who had lost weight (12 ± 4 ng/mL) or showed no weight change (11 ± 5 ng/mL; p < 0...
October 23, 2018: Journal of Cardiovascular Translational Research
Abdelrahman Elshafay, Ahmed Hesham Bendary, Huan Thanh Vuong, Ahmed Reda Ahmed, Mohamed Ashraf Mokhtar, Ali Lotfy Soliman, Nguyen Lam Vuong, Israa Atia El Bestawi, Nirmeen Atef Abdallah, Vi Tuong Vu, Kenji Hirayama, Nguyen Tien Huy
Saphenous vein (SV) is a common graft being used in coronary artery bypass grafting (CABG). Conventional (CON), intermediate (I), and no-touch (NT) are the most common harvesting techniques of SV for CABG. The aim of this study is to systematically review the NT versus CON and I techniques in harvesting SV for CABG. Twelve databases were searched for randomized controlled trials comparing the CON, I, and NT techniques in harvesting SV for CABG. Twelve reports of six RCTs were included. Our meta-analysis showed that with NT technique, patency rate was significantly higher when compared to I technique up to 18-month follow-up duration...
October 12, 2018: Journal of Cardiovascular Translational Research
Yong Liu, Qiang Li, Shiqun Chen, Xia Wang, Yingling Zhou, Ning Tan, Jiyan Chen
Development of simple non-invasive risk prediction model would help in early prediction of coronary artery disease (CAD) reducing the burden on public health. This paper demonstrates a risk prediction scoring system to predict obstructive coronary artery disease (OCAD) in CAD patients. A total of 13,082 patients, referred for coronary angiography (CAG) in TRUST trial, were included in the development of a multivariable diagnostic prediction model. External validation of the model used 1009 patients from PRECOMIN study...
October 12, 2018: Journal of Cardiovascular Translational Research
Lourdes Vicent, Helena Martínez-Sellés, Alejandro Lucia, Enzo Emanuele, Francisco Fernández-Avilés, Manuel Martínez-Sellés
No abstract text is available yet for this article.
October 9, 2018: Journal of Cardiovascular Translational Research
Suixin Liu, Fan Zheng, Ying Cai, Wenliang Zhang, Yaoshan Dun
LncRNA microarray analysis was applied to investigate the exercise effect on the global differential expressions of lncRNA and mRNA in aorta endothelium in insulin resistance. Twenty-four male C57BL/6 J mice were randomly divided into three groups: control group (n = 8), high-fat diet group (n = 8), and high-fat diet plus exercise training group (n = 8). An lncRNA microarray analysis was applied to investigate the global differential expressions of lncRNA and mRNA in aorta endothelium among three groups and the results were further verified by qPCR...
October 9, 2018: Journal of Cardiovascular Translational Research
Edoardo Bressi, Fabio Mangiacapra, Elisabetta Ricottini, Ilaria Cavallari, Iginio Colaiori, Giuseppe Di Gioia, Antonio Creta, Marialessia Capuano, Michele Mattia Viscusi, Germano Di Sciascio
The prognostic role of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with stable coronary artery disease (CAD) is still unclear. We enrolled 500 patients undergoing elective percutaneous coronary intervention (PCI). Blood samples were drawn prior to PCI for NLR and PLR calculation. Major adverse clinical events (MACE), which included death, myocardial infarction (MI), and target vessel revascularization (TVR), were recorded up to 5 years. Patients in the higher tertile of NLR presented higher Kaplan-Meier estimates of MACE (26...
October 1, 2018: Journal of Cardiovascular Translational Research
Daniel Kretzschmar, P Christian Schulze, Markus W Ferrari
Right heart failure (RHF) is a life-threatening condition. Mechanical right heart support offers an option for critically ill patients. The PERKAT® RV device is designed for percutaneous implantation in acute RHF. It consists of a nitinol chamber covered by foils containing inflow valves. An outlet tube is attached to its distal tip. Using an 18F sheath, it is implanted in the inferior vena cava while the tube bypasses the right heart with its tip in the pulmonary trunk. Then, an IABP balloon is inserted in the pump chamber...
September 28, 2018: Journal of Cardiovascular Translational Research
Laura Lahdentausta, Timo Sorsa, Erkki Pesonen, Pirkko Pussinen
No abstract text is available yet for this article.
September 24, 2018: Journal of Cardiovascular Translational Research
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