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Journal of Cardiovascular Translational Research

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https://www.readbyqxmd.com/read/29453747/clinical-applications-of-patient-specific-models-the-case-for-a-simple-approach
#1
Jeffrey W Holmes, Joost Lumens
Over the past several decades, increasingly sophisticated models of the heart have provided important insights into cardiac physiology and are increasingly used to predict the impact of diseases and therapies on the heart. In an era of personalized medicine, many envision patient-specific computational models as a powerful tool for personalizing therapy. Yet the complexity of current models poses important challenges, including identifying model parameters and completing calculations quickly enough for routine clinical use...
February 16, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29453746/effect-of-aerobic-exercise-on-treg-and-th17-of-rats-with-ischemic-cardiomyopathy
#2
Zhisong Chen, Wenwen Yan, Yu Mao, Yi Ni, Lin Zhou, Haoming Song, Wenjun Xu, Leming Wang, Yuqin Shen
Immune activation and inflammation participate in the progression of chronic heart failure (CHF). Th17 cells and CD4+CD25+ regulatory T (Treg) cells both come from naive Th cells and share reciprocal development pathways but exhibit opposite effects. We hypothesized that the Th17/Treg balance was impaired in patients with CHF, and exercise can improve it. Rats with ischemic cardiomyopathy were prepared by ligaturing the left anterior descending branch of the left coronary artery. Rats in training group were trained with treadmill; Th17 cells increased significantly while Treg cells significantly decreased in s by flow cytometry, and the peripheral blood level of IL-6, IL-17, and TNF-α was obviously elevated by ELISA assay...
February 16, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29404859/serum-exosomes-attenuate-h2o2-induced-apoptosis-in-rat-h9c2-cardiomyocytes-via-erk1-2
#3
Pengfei Li, Zhuyuan Liu, Yuan Xie, Huanyu Gu, Qiying Dai, Jianhua Yao, Lei Zhou
Exosomes are small-sized vesicles that can be released from cells into the serum. Exosomes play important roles in regulating many biological processes including cell proliferation, apoptosis, cell cycle, and metabolism. However, the roles and mechanisms of plasma exosomes in the apoptosis of rat H9C2 cardiomyocytes are largely unknown. In this study, we isolated plasma exosomes as confirmed by the marker protein CD63. Using flow cytometry and western blot analysis, we found that exosomes attenuated hydrogen peroxide (H2O2)-induced apoptosis and improved survival of rat H9C2 cardiomyocytes...
February 5, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29392537/enhanced-cardiac-s100a1-expression-improves-recovery-from-global-ischemia-reperfusion-injury
#4
S Jungi, X Fu, A Segiser, M Busch, P Most, M Fiedler, T Carrel, H Tevaearai Stahel, S L Longnus, Henriette Most
Gene-targeted therapy with the inotropic Ca2 + -sensor protein S100A1 rescues contractile function in post-ischemic heart failure and is being developed towards clinical trials. Its proven beneficial effect on cardiac metabolism and mitochondrial function suggests a cardioprotective effect of S100A1 in myocardial ischemia-reperfusion injury (IRI). Fivefold cardiomyocyte-specific S100A1 overexpressing, isolated rat hearts perfused in working mode were subjected to 28 min ischemia (37 °C) followed by 60 min reperfusion...
February 1, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29392536/retrograde-coronary-venous-infusion-as-a-delivery-strategy-in-regenerative-cardiac-therapy-an-overview-of-preclinical-and-clinical-data
#5
REVIEW
Wouter A Gathier, Dirk Jan van Ginkel, Mira van der Naald, Frebus J van Slochteren, Pieter A Doevendans, Steven A J Chamuleau
An important aspect of cell therapy in the field of cardiac disease is safe and effective delivery of cells. Commonly used delivery strategies such as intramyocardial injection and intracoronary infusion both present with advantages and disadvantages. Therefore, alternative delivery routes are explored, such as retrograde coronary venous infusion (RCVI). Our aim is to evaluate safety and efficiency of RCVI by providing a complete overview of preclinical and clinical studies applying RCVI in a broad range of disease types and experimental models...
February 1, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29349668/serum-mmp-9-diagnostics-prognostics-and-activation-in-acute-coronary-syndrome-and-its-recurrence
#6
Laura Lahdentausta, Jaakko Leskelä, Alina Winkelmann, Taina Tervahartiala, Timo Sorsa, Erkki Pesonen, Pirkko J Pussinen
Matrix metalloproteinase (MMP)-9 is crucial in atherosclerotic plaque rupture and tissue remodeling after a cardiac event. The balance between MMP-9 and endogenous inhibitor, tissue inhibitors of matrix metalloproteinase 1 (TIMP-1), is important in acute coronary syndrome (ACS). This is an age- and gender-matched case-control study of ACS (N = 669). Patients (45.7%) were resampled after recovery, and all were followed up for 6 years. The molecular forms of MMP-9 were investigated by gelatin zymography...
January 18, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29344841/association-of-d-dimer-with-plaque-characteristics-and-plasma-biomarkers-of-oxidation-specific-epitopes-in-stable-subjects-with-coronary-artery-disease
#7
Hema Kothari, Anh T Nguyen, Xiaohong Yang, Yohei Hisada, Sotirios Tsimikas, Nigel Mackman, Angela Taylor, Coleen A McNamara
D-dimer has emerged as a biomarker of cardiovascular event risk, yet pathophysiological factors associated with plasma D-dimer levels in stable coronary artery disease (CAD) subjects are poorly understood. In 106 stable CAD subjects undergoing intravascular ultrasound with virtual histology (IVUS-VH), we measured D-dimer, lipoprotein(a) (Lp(a)), plasminogen, biomarkers reflecting oxidation-specific epitopes (OSE) such as oxidized phospholipids on apolipoprotein B-100 (OxPL-apoB), OxPL on plasminogen (OxPL-PLG), and autoantibodies to phosphorylcholine-BSA [PC-BSA] and a malondialdehyde [MDA] mimotope...
January 17, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29344840/design-and-rationale-for-comparison-between-ticagrelor-and-clopidogrel-on-microcirculation-in-patients-with-acute-coronary-syndrome-undergoing-percutaneous-coronary-intervention-pleio-trial
#8
Kyungil Park, Young-Rak Cho, Jong-Sung Park, Tae-Ho Park, Moo-Hyun Kim, Young-Dae Kim
It has been previously demonstrated that ticagrelor can reduce mortality compared to clopidogrel in acute coronary syndrome (ACS) patients. However, the mechanism for this mortality reduction remains uncertain. The objective of the present study is to assess the impact of chronic ticagrelor treatment on microvascular circulation. A total of 120 participants aged 20-85 years with clinical diagnosis of ACS will be randomized in a 1:1 fashion to the following two groups: ticagrelor 90 mg twice daily; clopidogrel 75 mg once daily...
January 17, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29340873/fontan-surgical-planning-previous-accomplishments-current-challenges-and-future-directions
#9
Phillip M Trusty, Timothy C Slesnick, Zhenglun Alan Wei, Jarek Rossignac, Kirk R Kanter, Mark A Fogel, Ajit P Yoganathan
The ultimate goal of Fontan surgical planning is to provide additional insights into the clinical decision-making process. In its current state, surgical planning offers an accurate hemodynamic assessment of the pre-operative condition, provides anatomical constraints for potential surgical options, and produces decent post-operative predictions if boundary conditions are similar enough between the pre-operative and post-operative states. Moving forward, validation with post-operative data is a necessary step in order to assess the accuracy of surgical planning and determine which methodological improvements are needed...
January 16, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29340872/abstracts-of-the-2017-a-cure-symposium
#10
(no author information available yet)
No abstract text is available yet for this article.
January 16, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29327314/computational-modeling-for-cardiac-resynchronization-therapy
#11
Angela W C Lee, Caroline Mendonca Costa, Marina Strocchi, Christopher A Rinaldi, Steven A Niederer
Cardiac resynchronization therapy (CRT) is an effective treatment for heart failure (HF) patients with an electrical substrate pathology causing ventricular dyssynchrony. However 40-50% of patients do not respond to treatment. Cardiac modeling of the electrophysiology, electromechanics, and hemodynamics of the heart has been used to study mechanisms behind HF pathology and CRT response. Recently, multi-scale dyssynchronous HF models have been used to study optimal device settings and optimal lead locations, investigate the underlying cardiac pathophysiology, as well as investigate emerging technologies proposed to treat cardiac dyssynchrony...
January 11, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29313269/patient-specific-modeling-of-hemodynamics-supporting-surgical-planning-in-a-fontan-circulation-correction
#12
Theodorus M J van Bakel, Kevin D Lau, Jennifer Hirsch-Romano, Santi Trimarchi, Adam L Dorfman, C Alberto Figueroa
Computational fluid dynamics (CFD) is a modeling technique that enables calculation of the behavior of fluid flows in complex geometries. In cardiovascular medicine, CFD methods are being used to calculate patient-specific hemodynamics for a variety of applications, such as disease research, noninvasive diagnostics, medical device evaluation, and surgical planning. This paper provides a concise overview of the methods to perform patient-specific computational analyses using clinical data, followed by a case study where CFD-supported surgical planning is presented in a patient with Fontan circulation complicated by unilateral pulmonary arteriovenous malformations...
January 8, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29313268/trajectories-of-circulating-monocyte-subsets-after-st-elevation-myocardial-infarction-during-hospitalization-latent-class-growth-modeling-for-high-risk-patient-identification
#13
Shan Zeng, Li-Fang Yan, Yan-Wei Luo, Xin-Lin Liu, Jun-Xiang Liu, Zhao-Zeng Guo, Zhong-Wei Xu, Yu-Ming Li, Wen-Jie Ji, Xin Zhou
It remains unclear if the developmental trajectories of a specific inflammatory biomarker during the acute phase of ST-elevation myocardial infarction (STEMI) provide outcome prediction. By applying latent class growth modeling (LCGM), we identified three distinctive trajectories of CD14++CD16+ monocytes using serial flow cytometry assays from day 1 to day 7 of symptom onset in 96 de novo STEMI patients underwent primary percutaneous coronary intervention. Membership in the high-hump-shaped trajectory (16.8%) independently predicted adverse cardiovascular outcomes during a median follow-up of 2...
January 8, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29305798/the-use-of-computational-modeling-and-simulation-to-create-virtual-patients-application-to-cardiac-pacing-and-defibrillation-systems
#14
EDITORIAL
Adam Himes
No abstract text is available yet for this article.
January 5, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29294215/atlas-based-computational-analysis-of-heart-shape-and-function-in-congenital-heart-disease
#15
Kathleen Gilbert, Nickolas Forsch, Sanjeet Hegde, Charlene Mauger, Jeffrey H Omens, James C Perry, Beau Pontré, Avan Suinesiaputra, Alistair A Young, Andrew D McCulloch
Approximately 1% of all babies are born with some form of congenital heart defect. Many serious forms of CHD can now be surgically corrected after birth, which has led to improved survival into adulthood. However, many patients require serial monitoring to evaluate progression of heart failure and determine timing of interventions. Accurate multidimensional quantification of regional heart shape and function is required for characterizing these patients. A computational atlas of single ventricle and biventricular heart shape and function enables quantification of remodeling in terms of z scores in relation to specific reference populations...
January 2, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29285671/the-interleukin-33-st2-pathway-is-expressed-in-the-failing-human-heart-and-associated-with-pro-fibrotic-remodeling-of-the-myocardium
#16
Cheyenne C S Tseng, Manon M H Huibers, Joyce van Kuik, Roel A de Weger, Aryan Vink, Nicolaas de Jonge
The interleukin-33 (IL-33)/suppression of tumorigenicity 2 (ST2) pathway is a potential pathophysiological mediator of cardiac fibrosis. Soluble ST2 (sST2) is one of the main isoforms of ST2 with strong prognostic value in cardiac disease. The exact role of sST2 in cardiac fibrosis is unknown. The aim of this study was (1) to investigate myocardial expression of the IL-33/ST2 pathway in relation to myocardial fibrosis in end-stage heart failure patients and (2) to study whether plasma sST2 is associated with histologically determined cardiac fibrosis...
December 28, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29282628/patient-specific-modeling-of-stented-coronary-arteries-reconstructed-from-optical-coherence-tomography-towards-a-widespread-clinical-use-of-fluid-dynamics-analyses
#17
Claudio Chiastra, Susanna Migliori, Francesco Burzotta, Gabriele Dubini, Francesco Migliavacca
The recent widespread application of optical coherence tomography (OCT) in interventional cardiology has improved patient-specific modeling of stented coronary arteries for the investigation of local hemodynamics. In this review, the workflow for the creation of fluid dynamics models of stented coronary arteries from OCT images is presented. The algorithms for lumen contours and stent strut detection from OCT as well as the reconstruction methods of stented geometries are discussed. Furthermore, the state of the art of studies that investigate the hemodynamics of OCT-based stented coronary artery geometries is reported...
December 27, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29243014/prognostic-value-of-lvedp-in-acute-myocardial-infarction-a-systematic-review-and-meta-analysis
#18
Stephen C Brienesse, Allan J Davies, Arshad Khan, Andrew J Boyle
Left ventricular end-diastolic pressure (LVEDP) is an easily obtained, physiologically integrative measure of total LV function. LVEDP may be a useful prognostic measure in patients with acute myocardial infarction and utilised to guide medical therapy and assess risk for post myocardial infarction heart failure. To assess the utility of LVEDP as a prognostic measure in patients presenting with acute myocardial infarction. We performed an unrestricted search of electronic databases (1946 to March 2017) using a predefined search strategy...
December 14, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29209941/t2238c-atrial-natriuretic-peptide-gene-variant-and-the-response-to-antiplatelet-therapy-in-stable-ischemic-heart-disease-patients
#19
Teresa Strisciuglio, Emanuele Barbato, Chiara De Biase, Giuseppe Di Gioia, Maria Cotugno, Rosita Stanzione, Bruno Trimarco, Sebastiano Sciarretta, Massimo Volpe, Wiliam Wijns, Leen Delrue, Speranza Rubattu
The T2238C variant of the ANP gene is associated with higher risk of major cardiovascular events. The purpose of this study is to investigate if this polymorphism influences the response to antiplatelet agents and it is responsible of increased platelet reactivity, thus contributing to the adverse outcome. In patients undergoing elective percutaneous coronary intervention (PCI), loaded with antiplatelets, blood samples were withdrawn for genotyping, platelet reactivity assessment and for troponin T measurement to investigate the association between the polymorphism with residual platelet reactivity and with the incidence of PPMI...
December 5, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29204786/the-influence-of-comprehensive-cardiac-rehabilitation-on-heart-rate-variability-indices-after-cabg-is-more-effective-than-after-pci
#20
Katarzyna Szmigielska, Anna Szmigielska-Kapłon, Anna Jegier
The aim of this study was to evaluate the influence of cardiac rehabilitation (CR) on heart rate variability (HRV) indices in men with coronary artery disease (CAD) treated with percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery (CABG). The study population consisted of 131 male patients with CAD prospectively and consecutively admitted to CR after PCI n = 72, or CABG n = 59. Participants performed cycle ergometer interval training for 45 min three times a week for 8 weeks...
December 4, 2017: Journal of Cardiovascular Translational Research
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