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Journal of Cardiovascular Translational Research

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https://www.readbyqxmd.com/read/28718055/early-anti-inflammatory-and-pro-angiogenic-myocardial-effects-of-intravenous-serelaxin-infusion-for-72%C3%A2-h-in-an-experimental-rat-model-of-acute-myocardial-infarction
#1
Jesus Sanchez-Mas, Antonio Lax, Mari C Asensio-Lopez, Miriam Lencina, Maria J Fernandez-Del Palacio, Angela Soriano-Filiu, Rudolf A de Boer, Domingo A Pascual-Figal
Sprague Dawley rats were subjected to acute myocardial infarction (AMI) by permanent ligation of the left anterior descending coronary artery. At the time of AMI, a subcutaneous mini-osmotic pump was implanted and animals were randomized into three groups, according to the intravenous therapy received during the first 72 h: placebo-treated (saline), serelaxin10-treated (SRLX10 = 10 μg/kg/day), or serelaxin30-treated (SRLX30 = 30 μg/kg/day). Treatment with SRLX30 reduced the expression of inflammatory cytokines and chemokines, as well as the infiltration of macrophages, and increased the expression of pro-angiogenic markers and vessel density in the infarcted myocardium after 7 days...
July 17, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28702920/erratum-to-association-study-between-coronary-artery-disease-and-rs1333049-polymorphism-at-9p21-3-locus-in-italian-population
#2
Piero Pignataro, Lucia Pezone, Giuseppe Di Gioia, Danilo Franco, Guido Iaccarino, Achille Iolascon, Michele Ciccarelli, Mario Capasso
No abstract text is available yet for this article.
July 12, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28643179/erratum-to-various-regulatory-modes-for-circadian-rhythmicity-and-sexual-dimorphism-in-the-non-neuronal-cardiac-cholinergic-system
#3
Shino Oikawa, Yuko Kai, Asuka Mano, Hisayuki Ohata, Takahiro Nemoto, Yoshihiko Kakinuma
No abstract text is available yet for this article.
June 22, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28639227/association-study-between-coronary-artery-disease-and-rs1333049-polymorphism-at-9p21-3-locus-in-italian-population
#4
Piero Pignataro, Lucia Pezone, Giuseppe Di Gioia, Danilo Franco, Guido Iaccarino, Achille Iolascon, Michele Ciccarelli, Mario Capasso
In this study, we verify the association between the rs1333049 single nucleotide polymorphism (9p21.3) within CDKN2A-CDKN2B and coronary artery disease (CAD) in an Italian population. We replicated rs1333049_G allele association with a significantly reduced risk of CAD (OR = 0.816; 95% confidence interval [0.705-0.945]; p = 0.0065) in 711 CAD patients and 755 normal healthy individuals. This effect is maintained even stratifying patients by gender and by risk factors. A significant association was found with age of CAD onset...
June 21, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28631165/thoracic-aneurysms-and-dissections-towards-a-further-and-better-knowledge
#5
LETTER
María Martín, Laura Díaz-Chirón, José Rozado, Luis Gutiérrez de la Varga, José Julián Rodríguez Reguero, Rubén Alvarez Cabo, César Morís
No abstract text is available yet for this article.
June 19, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28577038/a-swine-model-of-percutaneous-intracoronary-ethanol-induced-acute-myocardial-infarction-and-ischemic-mitral-regurgitation
#6
Weiwei Shi, Bryant V McIver, Kanika Kalra, Eric L Sarin, Susan Schmarkey, Michael Duggan, Vinod H Thourani, Robert A Guyton, Muralidhar Padala
Ischemic mitral regurgitation (IMR) is a frequent complication after a myocardial infarction (MI), which doubles mortality. Transcatheter mitral repairs are emerging as alternative treatment options to open heart surgery for IMR, but animal models to test them are lacking. We report a percutaneous swine model of IMR. Seventeen swine were randomized to (group 1, n = 12) MI causing IMR, and (group 2, n = 5) controls. In group 1, MI was induced via percutaneous ethanol injection into the obtuse marginal branches of the left circumflex artery, resulting in ST elevating myocardial infarction...
June 2, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28567671/downregulation-of-the-complement-cascade-in-vitro-in-mice-and-in-patients-with-cardiovascular-disease-by-the-bet-protein-inhibitor-apabetalone-rvx-208
#7
Sylwia Wasiak, Dean Gilham, Laura M Tsujikawa, Christopher Halliday, Cyrus Calosing, Ravi Jahagirdar, Jan Johansson, Michael Sweeney, Norman C Wong, Ewelina Kulikowski
Apabetalone (RVX-208) is an epigenetic regulator developed to treat cardiovascular disease (CVD) that targets BET proteins. Through transcriptional regulation RVX-208 modulates pathways that underlie CVD including reverse cholesterol transport, vascular inflammation, coagulation, and complement. Using transcriptomics and proteomics we show that complement is one of the top pathways downregulated by RVX-208 in primary human hepatocytes (PHH) and in plasma from CVD patients. RVX-208 reduces basal and cytokine-driven expression of complement factors in PHH and in chimeric mice with humanized livers...
May 31, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28567670/severity-of-hypertension-correlates-with-risk-of-thromboembolic-stroke
#8
Hui Pang, Bing Han, Qiang Fu, Qiumei Cao
Hypertension plays a significant role in the development of atrial fibrillation (AF) and its complications. The coexistence of the two diseases increases the risk of thromboembolism events. Although CHADS2 and CHA2DS2-VASc scores have been used in the evaluation of the thromboembolism events in AF patients, the different levels of the blood pressure are not appropriately recognized. In this study, the 970 AF patients were divided into three groups according to the severity of hypertension. The CHADS2 and CHA2DS2-VASc scores in the patients of grade 3 hypertension were significantly higher than those of the patients with grade 1 and 2 hypertension, respectively (P < 0...
May 31, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28550590/exome-sequencing-identifies-candidate-genetic-modifiers-of-syndromic-and-familial-thoracic-aortic-aneurysm-severity
#9
Benjamin J Landis, Jeffrey A Schubert, Dongbing Lai, Anil G Jegga, Amy R Shikany, Tatiana Foroud, Stephanie M Ware, Robert B Hinton
Thoracic aortic aneurysm (TAA) is a genetic disease predisposing to aortic dissection. It is important to identify the genetic modifiers controlling penetrance and expressivity to improve clinical prognostication. Exome sequencing was performed in 27 subjects with syndromic or familial TAA presenting with extreme phenotypes (15 with severe TAA; 12 with mild or absent TAA). Family-based analysis of a subset of the cohort identified variants, genes, and pathways segregating with TAA severity among three families...
May 26, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28500574/tissue-engineering-bridging-the-gap
#10
EDITORIAL
Adrian H Chester
No abstract text is available yet for this article.
May 12, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28497301/various-regulatory-modes-for-circadian-rhythmicity-and-sexual-dimorphism-in-the-non-neuronal-cardiac-cholinergic-system
#11
Shino Oikawa, Yuko Kai, Asuka Mano, Hisayuki Ohata, Takahiro Nemoto, Yoshihiko Kakinuma
Cardiomyocytes possess a non-neuronal cardiac cholinergic system (NNCCS) regulated by a positive feedback system; however, its other regulatory mechanisms remain to be elucidated, which include the epigenetic control or regulation by the female sex steroid, estrogen. Here, the NNCCS was shown to possess a circadian rhythm; its activity was upregulated in the light-off phase via histone acetyltransferase (HAT) activity and downregulated in the light-on phase. Disrupting the circadian rhythm altered the physiological choline acetyltransferase (ChAT) expression pattern...
May 11, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28474304/the-notch-ligands-dll1-and-periostin-are-associated-with-symptom-severity-and-diastolic-function-in-dilated-cardiomyopathy
#12
Hilde M Norum, Kaspar Broch, Annika E Michelsen, Ida G Lunde, Tove Lekva, Aurelija Abraityte, Christen P Dahl, Arnt E Fiane, Arne K Andreassen, Geir Christensen, Svend Aakhus, Pål Aukrust, Lars Gullestad, Thor Ueland
In dilated cardiomyopathy (DCM), adverse myocardial remodeling is essential, potentially involving Notch signaling. We hypothesized that secreted Notch ligands would be dysregulated in DCM. We measured plasma levels of the canonical Delta-like Notch ligand 1 (DLL1) and non-canonical Notch ligands Delta-like 1 homologue (DLK1) and periostin (POSN) in 102 DCM patients and 32 matched controls. Myocardial mRNA and protein levels of DLL1, DLK1, and POSN were measured in 25 explanted hearts. Our main findings were: (i) Circulating levels of DLL1 and POSN were higher in patients with severe DCM and correlated with the degree of diastolic dysfunction and (ii) right ventricular tissue expressions of DLL1, DLK1, and POSN were oppositely associated with cardiac function indices, as high DLL1 and DLK1 expression corresponded to more preserved and high POSN expression to more deteriorated cardiac function...
May 4, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28462436/development-and-characterization-of-a-porcine-mitral-valve-scaffold-for-tissue-engineering
#13
M Granados, L Morticelli, S Andriopoulou, P Kalozoumis, M Pflaum, P Iablonskii, B Glasmacher, M Harder, J Hegermann, C Wrede, I Tudorache, S Cebotari, A Hilfiker, A Haverich, Sotirios Korossis
Decellularized scaffolds represent a promising alternative for mitral valve (MV) replacement. This work developed and characterized a protocol for the decellularization of whole MVs. Porcine MVs were decellularized with 0.5% (w/v) SDS and 0.5% (w/v) SD and sterilized with 0.1% (v/v) PAA. Decellularized samples were seeded with human foreskin fibroblasts and human adipose-derived stem cells to investigate cellular repopulation and infiltration, and with human colony-forming endothelial cells to investigate collagen IV formation...
May 1, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28681133/innovative-clinical-trial-designs-for-precision-medicine-in-heart-failure-with-preserved-ejection-fraction
#14
Sanjiv J Shah
A major challenge in the care of patients with heart failure and preserved ejection fraction (HFpEF) is the lack of proven therapies due to disappointing results from randomized controlled trials (RCTs). The heterogeneity of the HFpEF syndrome and the use of conventional RCT designs are possible reasons underlying the failure of these trials. There are several factors-including the widespread adoption of electronic health records, decreasing costs of obtaining high-dimensional data, and the availability of a wide variety of potential therapeutics-that have evolved to enable more innovative clinical trial designs in HFpEF...
June 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28585184/text-mining-of-the-electronic-health-record-an-information-extraction-approach-for-automated-identification-and-subphenotyping-of-hfpef-patients-for-clinical-trials
#15
Siddhartha R Jonnalagadda, Abhishek K Adupa, Ravi P Garg, Jessica Corona-Cox, Sanjiv J Shah
Precision medicine requires clinical trials that are able to efficiently enroll subtypes of patients in whom targeted therapies can be tested. To reduce the large amount of time spent screening, identifying, and recruiting patients with specific subtypes of heterogeneous clinical syndromes (such as heart failure with preserved ejection fraction [HFpEF]), we need prescreening systems that are able to automate data extraction and decision-making tasks. However, a major obstacle is the vast amount of unstructured free-form text in medical records...
June 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28585183/precision-medicine-for-heart-failure-with-preserved-ejection-fraction-an-overview
#16
Sanjiv J Shah
There are few proven therapies for heart failure with preserved ejection fraction (HFpEF). The lack of therapies, along with increased recognition of the disorder and its underlying pathophysiology, has led to the acknowledgement that HFpEF is heterogeneous and is not likely to respond to a one-size-fits-all approach. Thus, HFpEF is a prime candidate to benefit from a precision medicine approach. For this reason, we have assembled a compendium of papers on the topic of precision medicine in HFpEF in the Journal of Cardiovascular Translational Research...
June 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28432533/erratum-to-deep-phenotyping-of-systemic-arterial-hemodynamics-in-hfpef-part-1-physiologic-and-technical-considerations
#17
Julio A Chirinos
No abstract text is available yet for this article.
June 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28401511/deep-phenotyping-of-systemic-arterial-hemodynamics-in-hfpef-part-2-clinical-and-therapeutic-considerations
#18
Julio A Chirinos
Multiple phase III trials over the last few decades have failed to demonstrate a clear benefit of various pharmacologic interventions in heart failure with a preserved left ventricular (LV) ejection fraction (HFpEF). Therefore, a better understanding of its pathophysiology is important. An accompanying review describes key technical and physiologic aspects regarding the deep phenotyping of arterial hemodynamics in HFpEF. This review deals with the potential of this approach to enhance our clinical, translational, and therapeutic approach to HFpEF...
June 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28258421/phenomapping-for-the-identification-of-hypertensive-patients-with-the-myocardial-substrate-for-heart-failure-with-preserved-ejection-fraction
#19
Daniel H Katz, Rahul C Deo, Frank G Aguilar, Senthil Selvaraj, Eva E Martinez, Lauren Beussink-Nelson, Kwang-Youn A Kim, Jie Peng, Marguerite R Irvin, Hemant Tiwari, D C Rao, Donna K Arnett, Sanjiv J Shah
We sought to evaluate whether unbiased machine learning of dense phenotypic data ("phenomapping") could identify distinct hypertension subgroups that are associated with the myocardial substrate (i.e., abnormal cardiac mechanics) for heart failure with preserved ejection fraction (HFpEF). In the HyperGEN study, a population- and family-based study of hypertension, we studied 1273 hypertensive patients utilizing clinical, laboratory, and conventional echocardiographic phenotyping of the study participants. We used machine learning analysis of 47 continuous phenotypic variables to identify mutually exclusive groups constituting a novel classification of hypertension...
June 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28210939/deep-phenotyping-of-systemic-arterial-hemodynamics-in-hfpef-part-1-physiologic-and-technical-considerations
#20
REVIEW
Julio A Chirinos
A better understanding of the pathophysiology of heart failure with a preserved left ventricular ejection fraction (HFpEF) is important. Detailed phenotyping of pulsatile hemodynamics has provided important insights into the pathophysiology of left ventricular remodeling and fibrosis, diastolic dysfunction, microvascular disease, and impaired oxygen delivery to peripheral skeletal muscle, all of which contribute to exercise intolerance, the cardinal feature of HFpEF. Furthermore, arterial pulsatile hemodynamic mechanisms likely contribute to the frequent presence of comorbidities, such as renal failure and dementia, in this population...
June 2017: Journal of Cardiovascular Translational Research
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