Hongjuan Cao, Lina Zhao, Yao Yuan, Chunyan Liao, Weidan Zeng, Aiyue Li, Quanfeng Huang, Yueyao Zhao, Yubing Fan, Liu Jiang, Dandan Song, Sha Li, Bei Zhang
The process of myocardial hypertrophy in hypertension can lead to excessive activation of oxidative stress. Lipoamide (ALM) has significant antioxidant and anti-inflammatory effects. This study aimed to investigate the effects of ALM on hypertension-induced cardiac hypertrophy, as well as explore its underlying mechanisms. We evaluated the effects of ALM on spontaneously hypertensive rats and rat cardiomyocytes treated with Ang II. We found that ALM was not effective in lowering blood pressure in SHR, but it attenuated hypertension-mediated cardiac fibrosis, oxidative stress, inflammation, and hypertrophy in rats...
February 9, 2024: Journal of Cardiovascular Translational Research