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Journal of Cardiovascular Translational Research

Bryana M Levitan, Janet R Manning, Catherine N Withers, Jeffrey D Smith, Robin M Shaw, Douglas A Andres, Vincent L Sorrell, Jonathan Satin
Sympathetic stimulation modulates L-type calcium channel (LTCC) gating to contribute to increased systolic heart function. Rad is a monomeric G-protein that interacts with LTCC. Genetic deletion of Rad (Rad(-/-)) renders LTCC in a sympathomimetic state. The study goal was to use a clinically inspired pharmacological stress echocardiography test, including analysis of global strain, to determine whether Rad(-/-) confers tonic positive inotropic heart function. Sarcomere dynamics and strain showed partial parallel isoproterenol (ISO) responsiveness for wild-type (WT) and for Rad(-/-)...
October 31, 2016: Journal of Cardiovascular Translational Research
Hicham Skali, Robert Gerwien, Timothy E Meyer, James V Snider, Scott D Solomon, Craig M Stolen
Soluble ST2 is an established biomarker of heart failure (HF) progression. Data about its prognostic implications in patients with mildly symptomatic HF eligible to receive cardiac resynchronization therapy defibrillators (CRT-D) are limited. In a cohort of 684 patients enrolled in Multicenter Automated Defibrillator Implantation Trial (MADIT)-CRT, levels of soluble ST2 (sST2) were serially assessed at baseline and 1 year (n = 410). In multivariable-adjusted models, elevated baseline sST2 was associated with an increased risk of death, death or HF, and death or ventricular arrhythmia (VA) even when adjusting for baseline brain natriuretic protein (BNP) levels...
October 31, 2016: Journal of Cardiovascular Translational Research
Antoni Bayes-Genis
No abstract text is available yet for this article.
October 24, 2016: Journal of Cardiovascular Translational Research
Luís Leite, João Silva Marques, Vítor Matos, Lino Gonçalves, Manuel Antunes, Mariano Pego
No abstract text is available yet for this article.
October 12, 2016: Journal of Cardiovascular Translational Research
Michele Pighi, Fabrizio Tomai, Flavio Ribichini
No abstract text is available yet for this article.
October 11, 2016: Journal of Cardiovascular Translational Research
Zunzhe Wang, Xing Rong, Bihui Luo, Shanshan Qin, Lili Lu, Xiuli Zhang, Yeying Sun, Qin Hu, Chunxiang Zhang
Many cardiac aging studies are performed on mice first and then, due to difficulty in mouse cardiomyocyte culture, applied the rat neonatal cardiomyocytes to further determine the mechanisms in vitro. Now, the technological challenge of mouse cardiomyocyte culture has been overcome and there is an increasing need for the senescence models of mouse cardiomyocytes. In this study, we have demonstrated that the senescence of mouse cardiomyocytes occurred with the extended culture time as shown by the increased β-galactosidase staining, increased p53 expression, decreased telomere activity, shorted telomere length, increased production of ROS, increased cell apoptosis, and impaired mitochondrial ΔΨm...
September 15, 2016: Journal of Cardiovascular Translational Research
Hanna K Gaggin, Arianna M Belcher, Parul U Gandhi, Nasrien E Ibrahim, James L Januzzi
Little is known regarding objective predictors of cachexia affecting patients with heart failure (HF). We studied 108 stable chronic systolic HF patients with serial echocardiography and biomarker measurements over 10 months. Cachexia was defined as weight loss ≥5 % from baseline or final BMI <20 kg/m(2); 18.5 % developed cachexia. While there were no significant differences in baseline or serial echocardiographic measures in those developing cachexia, we found significant differences in baseline amino-terminal pro-B type natriuretic peptide (NT-proBNP), highly sensitive troponin I, sST2, and endothelin-1...
September 8, 2016: Journal of Cardiovascular Translational Research
Arne A N Bruyneel, Apurv Sehgal, Sophia Malandraki-Miller, Carolyn Carr
When stressed by ageing or disease, the adult human heart is unable to regenerate, leading to scarring and hypertrophy and eventually heart failure. As a result, stem cell therapy has been proposed as an ultimate therapeutic strategy, as stem cells could limit adverse remodelling and give rise to new cardiomyocytes and vasculature. Unfortunately, the results from clinical trials to date have been largely disappointing. In this review, we discuss the current status of the field and describe various limitations and how future work may attempt to resolve these to make way to successful clinical translation...
August 19, 2016: Journal of Cardiovascular Translational Research
Nasim Nosoudi, Aniqa Chowdhury, Steven Siclari, Vaideesh Parasaram, Saketh Karamched, Naren Vyavahare
Degeneration of elastin plays a vital role in the pathology and progression of abdominal aortic aneurysm (AAA). Our previous study showed that pentagalloyl glucose (PGG), a core derivative of tannic acid, hinders the development of AAAs in a clinically relevant animal model when applied locally. In this study, we tested whether targeted nanoparticles (NPs) can deliver PGG to the site of an aneurysm and prevent aneurysmal growth by protecting elastin. PGG-loaded albumin NPs with a surface-conjugated elastin-specific antibody were prepared...
August 19, 2016: Journal of Cardiovascular Translational Research
Evelien Nollet, Vicky Y Hoymans, Inez R Rodrigus, Dina De Bock, Marc Dom, Bruno Vanassche, Viviane O M Van Hoof, Nathalie Cools, Katrijn Van Ackeren, Kristien Wouters, Katrien Vermeulen, Christiaan J Vrints, Emeline M Van Craenenbroeck
To determine whether the presence of ischemic heart disease (IHD) per se, or rather the co-presence of heart failure (HF), is the primum movens for less effective stem cell products in autologous stem cell therapy, we assessed numbers and function of bone marrow (BM)-derived progenitor cells in patients with coronary artery disease (n = 17), HF due to ischemic cardiomyopathy (n = 8), non-ischemic HF (n = 7), and control subjects (n = 11). Myeloid and erythroid differentiation capacity of BM-derived mononuclear cells was impaired in patients with underlying IHD but not with non-ischemic HF...
August 2016: Journal of Cardiovascular Translational Research
Abhay B Ramachandra, Andrew M Kahn, Alison L Marsden
Mechanical stimuli are key to understanding disease progression and clinically observed differences in failure rates between arterial and venous grafts following coronary artery bypass graft surgery. We quantify biologically relevant mechanical stimuli, not available from standard imaging, in patient-specific simulations incorporating non-invasive clinical data. We couple CFD with closed-loop circulatory physiology models to quantify biologically relevant indices, including wall shear, oscillatory shear, and wall strain...
August 2016: Journal of Cardiovascular Translational Research
Janine C Deddens, Krijn R Vrijsen, Johanna M Colijn, Martinus I Oerlemans, Corina H G Metz, Els J van der Vlist, Esther N M Nolte-'t Hoen, Krista den Ouden, Sanne J Jansen Of Lorkeers, Tycho I G van der Spoel, Stefan Koudstaal, Ger J Arkesteijn, Marca H M Wauben, Linda W van Laake, Pieter A Doevendans, Steven A J Chamuleau, Joost P G Sluijter
Plasma-circulating microRNAs have been implicated as novel early biomarkers for myocardial infarction (MI) due to their high specificity for cardiac injury. For swift clinical translation of this potential biomarker, it is important to understand their temporal and spatial characteristics upon MI. Therefore, we studied the temporal release, potential source, and transportation of circulating miRNAs in different models of ischemia reperfusion (I/R) injury. We demonstrated that extracellular vesicles are released from the ischemic myocardium upon I/R injury...
August 2016: Journal of Cardiovascular Translational Research
Yukitaka Shizukuda, Dorothy J Tripodi, Douglas R Rosing
Hereditary hemochromatosis (HH) is a genetic disorder which affects the heart due to systemic iron overload and concomitant elevated oxidative stress. Increasing numbers of patients are diagnosed at an asymptomatic stage due to genetic testing. Subclinical abnormal left ventricular diastolic function (LVDF) and increased arrhythmias are noted in this population; however, the mechanism leading to these observances has not been well understood. In this study, we assessed the relationship between arrhythmia activity and biomarkers of oxidative stress and iron overload in order to elucidate the role of oxidative stress in this population since we observed a significant association with LVDF previously...
August 2016: Journal of Cardiovascular Translational Research
Raffaele Altara, Marco Manca, Marleen H Hessel, Yumei Gu, Laura C van Vark, K Martijn Akkerhuis, Jan A Staessen, Harry A J Struijker-Boudier, George W Booz, W Matthijs Blankesteijn
Chemokines are involved in the remodeling of the heart; however, their significance as biomarkers in heart failure is unknown. We observed that circulating CXCR3 receptor chemokines CXCL9 and CXCL10 in a rat model of heart failure were increased 1 week after myocardial infarction. CXCL10 was also increased in both remote and infarcted regions of the heart and remained elevated at 16 weeks; CXCL9 was elevated in the remote area at 1 week. In humans, hierarchical clustering and principal component analysis revealed that circulating CXCL10, MIP-1α, and CD40 ligand were the best indicators for differentiating healthy and heart failure subjects...
August 2016: Journal of Cardiovascular Translational Research
Udi Nussinovitch, Giorgi Shtenberg, Ariel Roguin, Yair Feld
Patients with unrevascularizable coronary artery disease represent a substantial number of all patients with coronary disease. However, their therapeutic options are limited; they endure recurrent hospitalizations, a poor quality of life and prognosis. We aim to investigate a novel alternative approach to the treatment of this common medical condition by using a specialized intra-aortic device with coiling properties capable of enhancing diastolic coronary flow. Both a mathematical analysis and in vitro study presented in the current study have yielded enhanced coronary diastolic blood flow and energetic advantages...
August 2016: Journal of Cardiovascular Translational Research
Arantxa Hervas, Amparo Ruiz-Sauri, Jose Gavara, Jose V Monmeneu, Elena de Dios, Cesar Rios-Navarro, Nerea Perez-Sole, Itziar Perez, Daniel Monleon, Jose M Morales, Gema Minana, Julio Nunez, Clara Bonanad, Ana Diaz, Jose M Vila, Francisco J Chorro, Vicente Bodi
In extensive nonreperfused myocardial infarction (MI), remote fibrosis has been documented. Early reperfusion by primary angioplasty represents the gold standard method to minimize the extension of the infarction. We aimed to ascertain whether fibrosis also affects remote regions in reperfused MI in swine and patients. Swine were subjected to a transient occlusion of the left anterior descending artery followed by 1-week or 1-month reperfusion. Collagen content in the remote area macroscopically, microscopically, by magnetic resonance microimaging, and at the molecular level was similar to controls...
August 2016: Journal of Cardiovascular Translational Research
Brian J Hanson, Ryan J Koene, Samit S Roy, Peter M Eckman, Ranjit John, Nadeem A Chaudhary, Jose Vega-Peralta
Obscure gastrointestinal bleeding (GIB) in patients with continuous-flow left ventricular assist devices (CF-LVAD) is common. Capsule endoscopy (CE) can be used in the diagnosis of obscure GIB. Safety and outcomes of CE in patients with CF-LVAD are unknown. The aim is to define the safety and outcomes of CE in this population. Paitents with CF-LVAD undergoing CE at a single center between 2007 and 2014 were retrospectively reviewed. Thirty-four CE studies were performed. Positive CE occurred in 19 studies. No clinically significant cardiac events occurred...
August 2016: Journal of Cardiovascular Translational Research
Cristiano Spadaccio, Francesco Nappi, Nawwar Al-Attar, Fraser W Sutherland, Christophe Acar, Antonio Nenna, Marcella Trombetta, Massimo Chello, Alberto Rainer
Synthetic grafts are widely used in cardiac and vascular surgery since the mid-1970s. Despite their general good performance, inability of mimicking the elastomechanical characteristics of the native arterial tissue, and the consequent lack of adequate compliance, leads to a cascade of hemodynamic and biological alterations deeply affecting cardiovascular homeostasis. Those concerns have been reconsidered in more contemporaneous surgical and experimental reports which also triggered some research efforts in the tissue engineering field towards the realization of biomimetic arterial surrogates...
August 2016: Journal of Cardiovascular Translational Research
Elien B Engels, Masih Mafi-Rad, Antonius M W van Stipdonk, Kevin Vernooy, Frits W Prinzen
Cardiac resynchronization therapy (CRT) is a well-known treatment modality for patients with a reduced left ventricular ejection fraction accompanied by a ventricular conduction delay. However, a large proportion of patients does not benefit from this therapy. Better patient selection may importantly reduce the number of non-responders. Here, we review the strengths and weaknesses of the electrocardiogram (ECG) markers currently being used in guidelines for patient selection, e.g., QRS duration and morphology...
August 2016: Journal of Cardiovascular Translational Research
Xin Wang, Ya-Feng Li, Gayani Nanayakkara, Ying Shao, Bin Liang, Lauren Cole, William Y Yang, Xinyuan Li, Ramon Cueto, Jun Yu, Hong Wang, Xiao-Feng Yang
There are limitations in the current classification of danger-associated molecular patterns (DAMP) receptors. To overcome these limitations, we propose a new paradigm by using endogenous metabolites lysophospholipids (LPLs) as a prototype. By utilizing a data mining method we pioneered, we made the following findings: (1) endogenous metabolites such as LPLs at basal level have physiological functions; (2) under sterile inflammation, expression of some LPLs is elevated. These LPLs act as conditional DAMPs or anti-inflammatory homeostasis-associated molecular pattern molecules (HAMPs) for regulating the progression of inflammation or inhibition of inflammation, respectively; (3) receptors for conditional DAMPs and HAMPs are differentially expressed in human and mouse tissues; and (4) complex signaling mechanism exists between pro-inflammatory mediators and classical DAMPs that regulate the expression of conditional DAMPs and HAMPs...
August 2016: Journal of Cardiovascular Translational Research
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