journal
Journals Journal of Cardiovascular Tran...

Journal of Cardiovascular Translational Research

https://read.qxmd.com/read/38472722/efficient-edge-ai-models-for-robust-ecg-abnormality-detection-on-resource-constrained-hardware
#1
JOURNAL ARTICLE
Zhaojing Huang, Luis Fernando Herbozo Contreras, Wing Hang Leung, Leping Yu, Nhan Duy Truong, Armin Nikpour, Omid Kavehei
This study introduces two models, ConvLSTM2D-liquid time-constant network (CLTC) and ConvLSTM2D-closed-form continuous-time neural network (CCfC), designed for abnormality identification using electrocardiogram (ECG) data. Trained on the Telehealth Network of Minas Gerais (TNMG) subset dataset, both models were evaluated for their performance, generalizability capacity, and resilience. They demonstrated comparable results in terms of F1 scores and AUROC values. The CCfC model achieved slightly higher accuracy, while the CLTC model showed better handling of empty channels...
March 12, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38427153/association-between-automated-3d-measurement-of-coronary-luminal-narrowing-and-risk-of-future-myocardial-infarction
#2
JOURNAL ARTICLE
Alessandro Candreva, Maurizio Lodi Rizzini, Karol Calò, Mattia Pagnoni, Daniel Munhoz, Claudio Chiastra, Jean-Paul Aben, Stephane Fournier, Olivier Muller, Bernard De Bruyne, Carlos Collet, Diego Gallo, Umberto Morbiducci
This study focuses on identifying anatomical markers with predictive capacity for long-term myocardial infarction (MI) in focal coronary artery disease (CAD). Eighty future culprit lesions (FCL) and 108 non-culprit lesions (NCL) from 80 patients underwent 3D quantitative coronary angiography. The minimum lumen area (MLA), minimum lumen ratio (MLR), and vessel fractional flow reserve (vFFR) were evaluated. MLR was defined as the ratio between MLA and the cross-sectional area at the proximal lesion edge, with lower values indicating more abrupt luminal narrowing...
March 1, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38411834/ppar%C3%AE-agonist-rosiglitazone-and-antagonist-gw9662-antihypertensive-effects-on-chronic-intermittent-hypoxia-induced-hypertension-in-rats
#3
JOURNAL ARTICLE
Ningzhi Zhang, Feng Wei, Sisi Ning, Jialu Hu, Hongtao Shi, Zhifeng Yao, Minna Tang, Yongqiao Zhang, Jiaxin Gong, Junbo Ge, Zhaoqiang Cui
The increased incidence of hypertension associated with obstructive sleep apnea (OSA) presents significant physical, psychological, and economic challenges. Peroxisome proliferator-activated receptor gamma (PPARγ) plays a role in both OSA and hypertension, yet the therapeutic potential of PPARγ agonists and antagonists for OSA-related hypertension remains unexplored. Therefore, we constructed a chronic intermittent hypoxia (CIH)-induced hypertension rat model that mimics the pathogenesis of OSA-related hypertension in humans...
February 27, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38409476/circulating-proteome-analysis-identifies-reduced-inflammation-after-initiation-of-hemodynamic-support-with-either-veno-arterial-extracorporeal-membrane-oxygenation-or-impella-in-patients-with-cardiogenic-shock
#4
JOURNAL ARTICLE
Nikolaos A Diakos, Lija Swain, Shreyas Bhave, Xiaoying Qiao, Towia Libermann, Jillian Haywood, Siya Goel, Shiva Annamalai, Michele Esposito, Haval Chweich, Anthony Faugno, Navin K Kapur
In-hospital mortality associated with cardiogenic shock (CS) remains high despite the use of percutaneous assist devices. We sought to determine whether support with VA-ECMO or Impella in patients with CS alters specific components of the plasma proteome. Plasma samples were collected before device implantation and 72 h after initiation of support in 11 CS patients receiving ECMO or Impella. SOMAscan was used to detect 1305 circulating proteins. Sixty-seven proteins were changed after ECMO (18 upregulated and 49 downregulated, p < 0...
February 26, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38409475/allograft-model-of-aortic-arch-segment-grafting-to-abdominal-aorta-through-end-to-side-anastomosis-in-mice
#5
JOURNAL ARTICLE
Chiyu Liu, Qi Chen, Mingyuan He, Yulin Liao
The mouse aortic transplantation model is a valuable tool for investigating the mechanisms of atherosclerosis regression, but few laboratories can generate it due to the operation difficulty, especially for the style of end-to-side anastomosis, which facilitates syngeneic heterotopic transplanting a plaque-rich aortic arch into the abdominal aorta. Here we provide a modified protocol for generating this allograft model, which is capable of overcoming several critical surgical challenges such as separating a longer abdominal aorta segment, reducing bleeding and thrombosis, optimizing aortotomy, and improving end-to-side anastomosis to guarantee a potent graft...
February 26, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38409474/impact-of-perivascular-adipose-tissue-on-neointimal-formation-following-endovascular-placement
#6
REVIEW
Belay Tesfamariam
Following the placement of endovascular implants, perivascular adipose tissue (PVAT) becomes an early sensor of vascular injury to which it responds by undergoing phenotypic changes characterized by reduction in the secretion of adipocyte-derived relaxing factors and a shift to a proinflammatory and pro-contractile state. Thus, activated PVAT loses its anti-inflammatory function, secretes proinflammatory cytokines and chemokines, and generates reactive oxygen species, which are accompanied by differentiation of fibroblasts into myofibroblasts and proliferation of smooth muscle cells...
February 26, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38376702/percutaneous-alginate-hydrogel-endomyocardial-injection-with-a-novel-dedicated-catheter-delivery-system-an-animal-feasibility-study
#7
JOURNAL ARTICLE
Bo Wang, Chao Gao, Scott Lim, Rutao Wang, Cun-Jun Zhu, Yoshinobu Onuma, Yunbing Wang, Runlin Gao, Patrick W J C Serruys, Randall J Lee, Ling Tao
The objective of this preclinical study was to evaluate the feasibility and safety of transcatheter endocardial alginate hydrogel injection (TEAi) in a large animal model, utilizing the high-stiffness XDROP® alginate hydrogel in combination with the dedicated EndoWings® catheter-based system. All swine (n = 9) successfully underwent TEAi without complications. Acute results from a subset of animals (n = 5) demonstrated the ability of the catheter to access a wide range of endomyocardial areas and achieve consecutive circumferential hydrogel distribution patterns within the mid-left ventricular wall...
February 20, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38376701/transplantation-of-human-embryonic-stem-cell-derived-pericyte-like-cells-transduced-with-basic-fibroblast-growth-factor-promotes-angiogenic-recovery-in-mice-with-severe-chronic-hindlimb-ischemia
#8
JOURNAL ARTICLE
Kenichiro Shimatani, Hiromu Sato, Kazuhiko Mizukami, Atsuhiro Saito, Masao Sasai, Jun-Ichiro Enmi, Kenichi Watanabe, Masazumi Kamohara, Yoshichika Yoshioka, Shigeru Miyagawa, Yoshiki Sawa
Critical limb ischemia (CLI) is a state of severe peripheral artery disease, with no effective treatment. Cell therapy has been investigated as a therapeutic tool for CLI, and pericytes are promising therapeutic candidates based on their angiogenic properties. We firstly generated highly proliferative and immunosuppressive pericyte-like cells from embryonic stem (ES) cells. In order to enhance the angiogenic potential, we transduced the basic fibroblast growth factor (bFGF) gene into the pericyte-like cells and found a significant enhancement of angiogenesis in a Matrigel plug assay...
February 20, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38376700/exploration-of-the-potential-biomarker-fndc5-for-discriminating-heart-failure-in-patients-with-coronary-atherosclerosis
#9
JOURNAL ARTICLE
Hongchao Zheng, Yuntao Zheng, Wei Huang, Lingling Jiang, Siyu Liu, Peizhi Miao, Ning Zhu, Richard Y Cao
Coronary atherosclerosis leading to ischemic artery disease is one of the etiological factors to develop heart failure (HF). This study aimed to investigate potential biomarkers for discriminating HF in atherosclerotic patients. This study included 40 consecutive atherosclerotic patients who underwent angiography. Concentrations of B-type natriuretic peptide (BNP), fibronectin type III domain containing 5 (FNDC5), and Phosphodiesterase 9A (PDE9A) were measured in 20 atherosclerotic patients with HF symptoms/signs and 20 without HF symptoms/signs...
February 20, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38356018/metabolic-reprogramming-in-cardiovascular-diseases
#10
EDITORIAL
Juan Gao, Yujiao Zhu, Yihua Bei
No abstract text is available yet for this article.
February 14, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38351282/reply-to-correspondence-on-absence-of-myocardial-involvement-after-sars-cov-2-vaccination-in-asymptomatic-adolescents
#11
EDITORIAL
Rocío Párraga, Carlos Real, Rodrigo Fernández-Jiménez
No abstract text is available yet for this article.
February 13, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38349586/changes-in-cardiac-electrical-biomarker-in-response-to-coronary-arterial-occlusion-an-experimental-observation
#12
JOURNAL ARTICLE
Sudipta Chattopadhyay, Felicia Adjei, Attila Kardos
Cardiac electrical biomarker (CEB), an indicator of ischaemia-induced change in myocyte polarity, has been proposed for diagnosis of acute coronary syndrome. However, effect of coronary occlusion on CEB has not been demonstrated. CEB was acquired before (CEB0), during maximal adenosine hyperaemia (CEBhyp), balloon inflations (CEBmax) and 1 (CEB1h), 2 (CEB2h) and 3 (CEB3h) h after percutaneous coronary intervention along with pre- and post-procedural troponin-I. CEB of subjects with non-cardiac chest pain without risk factors was used as controls (CEBc)...
February 13, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38349585/myocardial-involvement-after-sars-cov-2-vaccination-in-asymptomatic-adolescents-correspondence
#13
EDITORIAL
Hinpetch Daungsupawong, Viroj Wiwanitkit
No abstract text is available yet for this article.
February 13, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38347336/cd137-signaling-mediates-pulmonary-artery-endothelial-cell-proliferation-under-hypoxia-by-regulating-mitochondrial-dynamics
#14
JOURNAL ARTICLE
Hao Xia, Junying Duan, Mei Li, Nan Chen, Wei Zhong, Ye Zhou, Rui Chen, Wei Yuan
Altered mitochondrial dynamics affect pulmonary artery endothelial cells (PAECs) proliferation, contributing to the development of pulmonary hypertension. CD137 signaling promotes mitochondrial fission. We hypothesize CD137 signaling is involved in the excessive proliferation of PAECs. The levels of CD137 protein were increased in the lung tissue of hypoxic mice and hypoxic-stimulated PAECs. Activation of CD137 signal in hypoxic-PAECs upregulated the levels of hypoxia-inducible factor-2α (HIF-2α), glucose transporters type 4, the lactate transporter monocarboxylate transporter 4, key glycolysis rate-limiting enzymes and promoted mitochondrial division; moreover, increased glucose uptake, lactic acid and ATP production and proliferative cells were observed in these PAECs...
February 12, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38334842/best-paper-of-the-year-2023
#15
EDITORIAL
Craig Stolen, Enrique Lara-Pezzi
No abstract text is available yet for this article.
February 9, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38334841/lipoamide-attenuates-hypertensive-myocardial-hypertrophy-through-pi3k-akt-mediated-nrf2-signaling-pathway
#16
JOURNAL ARTICLE
Hongjuan Cao, Lina Zhao, Yao Yuan, Chunyan Liao, Weidan Zeng, Aiyue Li, Quanfeng Huang, Yueyao Zhao, Yubing Fan, Liu Jiang, Dandan Song, Sha Li, Bei Zhang
The process of myocardial hypertrophy in hypertension can lead to excessive activation of oxidative stress. Lipoamide (ALM) has significant antioxidant and anti-inflammatory effects. This study aimed to investigate the effects of ALM on hypertension-induced cardiac hypertrophy, as well as explore its underlying mechanisms. We evaluated the effects of ALM on spontaneously hypertensive rats and rat cardiomyocytes treated with Ang II. We found that ALM was not effective in lowering blood pressure in SHR, but it attenuated hypertension-mediated cardiac fibrosis, oxidative stress, inflammation, and hypertrophy in rats...
February 9, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38326541/correction-microrna-208a-a-good-diagnostic-marker-and-a-predictor-of-no-reflow-in-stemi-patients-undergoing-primary-percutaneuos-coronary-intervention
#17
Aboubakr Mohamed Salama, Wael Ali Khalil, Manar Al-Zaky, Somia Hassan Abdallah, Nader Talaat Kandil, Ahmed Abdelsabour, Ahmed Mohammed Shaker, Mesbah Taha Hasanein, Giovanni Battista Luciani, Hassan M E Azzazy
No abstract text is available yet for this article.
February 7, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38300356/flavour-study-flow-profiles-and-postoperative-vasoplegia-after-continuous-flow-left-ventricular-assist-device-implantation
#18
JOURNAL ARTICLE
Bas J Kersten, Lieke Numan, Marnix M van der Schoot, Michel de Jong, Faiz Ramjankhan, Emmeke Aarts, Marish I F J Oerlemans, Linda W van Laake, Eric E C de Waal
This study aims to associate the incidence of postoperative vasoplegia and short-term survival to the implantation of various left ventricular assist devices differing in hemocompatibility and flow profiles. The overall incidence of vasoplegia was 25.3% (73/289 patients) and 30.3% (37/122), 25.0% (18/72), and 18.9% (18/95) in the axial flow (AXF), centrifugal flow (CF), and centrifugal flow with artificial pulse (CFAP) group, respectively. Vasoplegia was associated with longer intensive care (ICU) and hospital length of stay (LOS) and mortality...
February 1, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38294628/therapeutic-strategies-for-angiogenesis-based-on-endothelial-cell-epigenetics
#19
REVIEW
Yue Cai, Lihua Li, Chen Shao, Yiliu Chen, Zhongqun Wang
With the in-depth investigation of various diseases, angiogenesis has gained increasing attention. Among the contributing factors to angiogenesis research, endothelial epigenetics has emerged as an influential player. Endothelial epigenetic therapy exerts its regulatory effects on endothelial cells by controlling gene expression, RNA, and histone modification within these cells, which subsequently promotes or inhibits angiogenesis. As a result, this therapeutic approach offers potential strategies for disease treatment...
January 31, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38294627/mzb1-attenuates-atherosclerotic-plaque-vulnerability-in-apoe-mice-by-alleviating-apoptosis-and-modulating-mitochondrial-function
#20
JOURNAL ARTICLE
Guanglang Zhu, Yang Li, Hongxia Gao, Xu Li, Heyu Fan, Longhua Fan
In this study, we investigated the protective role of Mzb1 in atherosclerotic plaque vulnerability. To explore the impact of Mzb1, we analyzed Mzb1 expression, assessed apoptosis, and evaluated mitochondrial function in atherosclerosis (AS) mouse models and human vascular smooth muscle cells (HVSMCs). We observed a significant decrease in Mzb1 expression in AS mouse models and ox-LDL-treated HVSMCs. Downregulation of Mzb1 increased ox-LDL-induced apoptosis and cholesterol levels of HVSMCs, while Mzb1 overexpression alleviated these effect...
January 31, 2024: Journal of Cardiovascular Translational Research
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