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Hematology/oncology and Stem Cell Therapy

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https://www.readbyqxmd.com/read/30336122/impact-of-cd39-expression-on-cd4-t-lymphocytes-and-6q-deletion-on-outcome-of-patients-with-chronic-lymphocytic-leukemia
#1
Eman Mosaad Zaki, Asmaa Mohamed Zahran, Alshimaa Abdelazeem Metwaly, Rania Hafez, Safinaz Hussein, Abdallah Elaiw Mohammed
OBJECTIVE/BACKGROUND: Chronic lymphocytic leukemia is one of the commonest leukemias affecting adults. CD39 inhibits T-cell and Natural killer (NK) cell responses by hydrolyzing adenosine triphosphate and adenosine diphosphate, suppressing the immune system. We investigated expression of CD39 on CD4+ T Lymphocytes in chronic lymphocytic leukemia (CLL) patients and its relationship with deletion 6q, its association with disease stage and survival. METHODS: Thirty CLL patients and 20 matched controls were included in the study...
October 11, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/30291826/durable-remission-of-a-patient-with-primary-cutaneous-cd8-aggressive-epidermotropic-cytotoxic-t-cell-lymphoma
#2
Shaima M Al Aoun, Shahid Iqbal, Tahani M AlHalouli, Syed Z Zaidi, Ibraheem H Motabi
Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma (CD8+ PCAETL) is a rare disease characterized by aggressive clinical course and short survival. All available data are extracted from case reports and case series. The outcome is dismal and only two reported cases were cured after several lines of therapies including stem cell transplant. We herein present the case of a patient with CD8+ PCAETL who presented with rapidly progressive skin lesions and systemic symptoms. He was treated with aggressive multiagent chemotherapy comprising cyclophosphamide, vincristine, doxorubicin, and dexamethasone alternating with high-dose methotrexate and cytarabine (hyper-CVAD)...
September 28, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/30291825/early-posttraumatic-changes-in-coagulation-and-fibrinolysis-systems-in-isolated-severe-traumatic-brain-injury-patients-and-its-influence-on-immediate-outcome
#3
Venencia Albert, Subramanian Arulselvi, Deepak Agrawal, Hara Prasad Pati, Ravindra Mohan Pandey
OBJECTIVE/BACKGROUND: Early coagulopathy in isolated severe traumatic brain injury occurs despite the lack of severe bleeding, shock, and fluid administration. We aimed to correlate coagulation activation/inhibition, thrombin generation and fibrinolysis with the development of acute trauma induced coagulopathy (TIC) and its effects on early mortality in isolated severe traumatic brain injury (iSTBI) patients. METHODS: A prospective screening of iSTBI patients was done for two years...
September 27, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/30261180/cutaneous-light-chain-amyloidosis-with-multiple-myeloma-a-concise-review
#4
REVIEW
Mirela Andrei, Jen Chin Wang
OBJECTIVE/BACKGROUND: Cutaneous immunoglobulin (Ig) amyloid light-chain (AL) amyloidosis associated with overt multiple myeloma (MM) is rare and optimal treatment is not well defined. The recently developed highly efficacious MM therapy has brought on a new set of challenges to this field for consideration. The goal of this paper is to describe the characteristics of cutaneous manifestations of systemic AL amyloidosis associated with MM according to age, sex, race, Ig type, plasma cell percentage, and cytogenetic and fluorescent in situ hybridization studies along with their outcomes...
September 21, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/30248313/clinical-and-histopathological-spectrum-of-toxic-erythema-of-chemotherapy-in-patients-who-have-undergone-allogenic-hematopoietic-cell-transplantation
#5
Manrup K Hunjan, Somaira Nowsheen, Alvaro J Rodriguez, Shahrukh K Hashmi, Alina G Bridges, Julia S Lehman, Rokea El-Azhary
OBJECTIVE/BACKGROUND: Toxic erythema of chemotherapy (TEC) is a well-recognized adverse cutaneous reaction to chemotherapy. Similar to many skin diseases, the clinical presentations may vary. Our objective is to expand on the typical and atypical clinical and histopathological presentations of TEC. METHODS: Forty-two patients with a diagnosis of TEC were included from 500 patients who had undergone an allogenic hematopoietic stem cell transplant. Relevant information and demonstrative photos and pathology were selected...
September 20, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/30213610/vitamin-d-deficiency-and-graft-versus-host-disease-in-hematopoietic-stem-cell-transplant-population
#6
REVIEW
Abeer Arain, Chance Matthiesen
Vitamins are the organic compounds that have long been known to play a significant role in our body by functioning as hormones and antioxidants. Vitamin D, a fat-soluble vitamin, is the main regulator of calcium hemostasis in our body. At the same time, it is also known to show its potential effects on the immune system by modulating the differentiation, activation, and proliferation of T and B lymphocytes. The immunomodulatory properties of vitamin D are also known to have a crucial role in the prevention and treatment of graft-versus-host disease...
September 8, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/30176244/combined-haploidentical-and-umbilical-cord-blood-transplantation-for-severe-aplastic-anemia-unique-hematopoietic-reconstitution
#7
Anant Vatsayan, Hasan Hashem, Kristen Nagle, Linda Cabral, Hillard Lazarus, Jignesh Dalal
No abstract text is available yet for this article.
August 29, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29729225/diagnostic-utility-of-glycosyltransferase-mrna-expression-in-gastric-cancer
#8
Showkat Ahmad Bhat, Manzoor Ur Rahman Mir, Sabhiya Majid, Tehseen Hassan, Muneeb U Rehman, Sonallah Kuchy
OBJECTIVE/BACKGROUND: Posttranslational modification of proteins, including glycosylation, is known to differ between normal and tumor cells. Altered glycosyltransferase levels have been observed in tumor tissues and their role in tumor metastasis and invasion has been implicated. In this study the role of altered glycosyltransferase messenger RNA (mRNA) levels in serum of gastric cancer patients as early markers of gastric cancer was evaluated. METHODS: In this case control study the expression profile of ppGalNAc-T6, GlcNAcT-V, ST3Gal I, ST3 Gal IV, and ST6GalNAc-I in normal healthy control and gastric cancer patients was compared...
September 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29684340/myeloid-sarcoma-with-megakaryoblastic-differentiation-presenting-as-a-breast-mass
#9
Ifeyinwa E Obiorah, Metin Ozdemirli
Myeloid sarcoma is an extramedullary tumor that consists of myeloblasts or immature myeloid cells. The neoplasm can occur in any part of the body, including the bone, periosteum, lymph nodes, skin, and soft tissue and they may occur de novo or in association with acute myeloid leukemia, myeloproliferative neoplasms and myelodysplastic syndromes. Most cases display a myelomonocytic or pure monoblastic morphology. Tumors with megakaryoblastic differentiation are extremely uncommon and may occur in association with transformation of a myeloproliferative disorder...
September 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29476707/damocles-syndrome-revisited-update-on-the-fear-of-cancer-recurrence-in-the-complex-world-of-today-s-treatments-and-survivorship
#10
REVIEW
Margaret Cupit-Link, Karen L Syrjala, Shahrukh K Hashmi
OBJECTIVE/BACKGROUND: Improvements in curative treatments for many types of cancer have emerged over the past several decades, resulting in a growing population of long-term cancer survivors - of both adult and childhood cancers. Despite this incredible medical achievement, long-term survivors of cancer face a unique fear: the fear of relapse. METHODS: We conducted a review of the literature for data on fear of relapse among cancer survivors. RESULTS: The fear of cancer recurrence is present in survivors of childhood and adult cancers as well as family members and often leads to psychological sequelae...
September 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29474820/effects-of-two-doses-of-anti-t-lymphocyte-globulin-fresenius-given-after-full-match-sibling-stem-cell-transplantation-in-acute-myeloblastic-leukemia-patients-who-underwent-myeloablative-fludarabine-busulfan-conditioning
#11
Can Boga, Mahmut Yeral, Ciğdem Gereklioglu, Suheyl Asma, Erkan Maytalman, Pelin Aytan, Ilknur Kozanoglu, Cagla Sariturk, Hakan Ozdogu
OBJECTIVE/BACKGROUND: Anti-T lymphocyte globulin Fresenius (rATG-F; ATG-Fresenius) and antithymocyte globulin (thymoglobulin), which are included in transplant protocols, are used to reduce the risk of chronic graft-versus-host disease (cGVHD) or suppress allograft rejection. Available clinical studies have been conducted in heterogenous patient populations and with different administration protocols including stem cell sources. Additionally, the pharmacokinetics of ATG is variable, and the clinically effective dose of rATG-F, in particular, is not exactly known...
September 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29406240/ibritumomab-tiuxetan-zevalin-and-elevated-serum-human-anti-murine-antibody-hama
#12
REVIEW
Sarbajit Mukherjee, Adanma Ayanambakkam, Sami Ibrahimi, Sarah Schmidt, Jennifer Holter Charkrabarty, Mohamad Khawandanah
Ibritumomab Tiuxetan (Zevalin) is an anti CD-20 murine monoclonal antibody linked to the radio-isotope 90-yttrium (90Y) by the chelator Tiuxetan. It is FDA approved for treatment of relapsed low grade or follicular B-cell Non-Hodgkin's Lymphoma (NHL) or newly diagnosed follicular NHL following an initial response to first-line chemotherapy. Patients may develop Human Anti-Murine Antibodies (HAMA), following exposure to murine antibodies. There is a concern for development of hypersensitivity reactions with Ibritumomab, especially in patients with an elevated HAMA titer...
September 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29397333/beliefs-about-hydroxyurea-in-youth-with-sickle-cell-disease
#13
Sherif M Badawy, Alexis A Thompson, Robert I Liem
BACKGROUND: Hydroxyurea reduces complications and improves health-related quality of life (HRQOL) in sickle cell disease (SCD) patients, however adherence remains suboptimal. Understanding patients' views of hydroxyurea is critical to optimize adherence, particularly in adolescents and young adults (AYA). Study objectives were to assess beliefs about hydroxyurea using the Beliefs about Medicines Questionnaire (BMQ), and to examine the relationship of patients' beliefs to their hydroxyurea adherence and HRQOL...
September 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29397331/fecal-calprotectin-and-serum-albumin-as-markers-of-gastrointestinal-graft-versus-host-disease
#14
Larisa Broglie, Alfred Rademaker, John Galvin, Ayita Ray, William T Tse, Reggie Duerst, Jennifer Schneiderman, Morris Kletzel, Sonali Chaudhury
BACKGROUND: Acute graft versus host disease (aGVHD) affects approximately 30-60% of patients after allogeneic hematopoietic stem cell transplantation (HCT) and our ability to predict who develops this complication and their response to treatment is limited. Fecal calprotectin has recently gained popularity as an effective marker of GI inflammation in patients with Inflammatory Bowel Disease (IBD). METHODS: Fecal calprotectin and albumin were evaluated as prognostic and predictive markers of aGVHD in 60 adult and pediatric HCT patients...
September 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29278676/utility-of-routine-surveillance-imaging-for-diffuse-large-b-cell-lymphoma-post-autologous-transplant-a-single-center-experience
#15
Ghulam Rehman Mohyuddin, Ashley Elizabeth Clark, John Roller, Leyla Shune, Tara Lin, Neil Dunavin, Ajoy Dias, Siddhartha Ganguly, Sunil Abhyankar, Joseph McGuirk, Anurag Singh
Surveillance scans after autologous stem cell transplant (auto-HCT) for patients with relapsed/refractory (RR) diffuse large B Cell lymphoma (DLBCL) have no proven survival benefit. We studied survival differences among patients with RR DLBCL post auto-HCT whose recurrences were detected clinically versus with routine surveillance imaging. Among the 139 patients with RR DLBCL that underwent auto-HCT from 2000 to 2014 at our institution, 37 relapsed: 21 clinical and 16 radiological. The median time to progression was 167 days for the clinical cohort and 565 days for the radiological cohort (p = 0...
September 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29222965/co-existence-of-myeloid-neoplasm-and-monoclonal-gammopathy-case-series-and-review-of-literature
#16
Navkirti Mittal, Ruchi Gupta, Khaliqur Rahman, Tanvi Gupta, Soniya Nityanand
No abstract text is available yet for this article.
September 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28867175/thrombo-hemorrhagic-liability-in-children-with-congenital-heart-diseases
#17
Shebl Said Shebl, Walid Ahmed Naguib El-Shehaby, Yasmin Shebl Said, Amira Hamed Darwish, Nabeh Helal Elfadaly, Eman Amer
BACKGROUND: The precise mechanisms of the increased incidence of hemostatic abnormalities in congenital heart disease (CHD) have not been determined. The aim of the study was to evaluate some indicators of activation of platelets and vascular endothelial cells in patients with CHD, evaluation of bleeding liability of these patients, and correlation with the clinical presentation of these patients. METHODS: This work was carried out on 20 patients with cyanotic congenital heart diseases (CCHD), 20 patients with acyanotic congenital heart diseases (ACHD), and 20 healthy children who served as the control group, aged between 1 and 10years...
September 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/27793577/a-novel-tnfrsf1a-gene-mutation-in-a-patient-with-tumor-necrosis-factor-receptor-associated-periodic-syndrome
#18
Alireza Khabazi, Mahafarin Maralani, Sasan Andalib, Ebrahim Sakhinia
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is a periodic fever syndrome inherited in an autosomal dominant fashion. It stems from mutations in the TNFRSF1A (accession number: NM_001065) gene expressing the receptor for tumor necrosis factor α. A patient with TRAPS may present with prolonged episodes of fever attacks, abdominal pain, severe myalgia, and painful erythema on the trunk or extremities. Here, we report an 8-year-old boy with febrile attacks occurring every 1-2months and continuing for 3-4days...
September 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/30076790/kidney-dysfunction-after-hematopoietic-cell-transplantation-etiology-management-and-perspectives
#19
REVIEW
Dorota Jaguś, Karol Lis, Longin Niemczyk, Grzegorz W Basak
Kidney dysfunction is a common complication of hematopoietic cell transplantation (HCT) with proven negative impact on early and long-term mortality. Causes of this complication are diverse, usually overlapping, and poorly understood. Therefore, management implicates multidirectional investigations and simultaneous treatment of suspected causes. The etiology is frequently unconfirmed due to a lack of specific markers and prevalence of contraindications to renal biopsy among HCT recipients. Herein, we provide a summary of etiology and propose an algorithm for evaluation of kidney injury after HCT...
July 29, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/30075096/autologous-hematopoietic-stem-cell-transplant-is-safe-for-elderly-lymphoma-patients
#20
Ghulam Rehman Mohyuddin, Nicole Romanelli, Leyla Shune, Sunil Abhyankar, Siddhartha Ganguly, Joseph McGuirk, Anurag Singh
No abstract text is available yet for this article.
July 29, 2018: Hematology/oncology and Stem Cell Therapy
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