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Hematology/oncology and Stem Cell Therapy

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https://www.readbyqxmd.com/read/28183684/prognosis-biomarkers-evaluation-in-chronic-lymphocytic-leukemia
#1
Lorena Caixeta Gomes, Fernanda Cristina Gontijo Evangelista, Lirlândia Pires de Sousa, Sergio Schusterschitz da Silva Araujo, Maria das Graças Carvalho, Adriano de Paula Sabino
OBJECTIVE/BACKGROUND: From clinical and biological points of view, chronic lymphocytic leukemia (CLL) is a heterogeneous disease characterized by a progressive accumulation of lymphocytes in the peripheral blood, bone marrow, and lymphoid organs. New prognostic markers in CLL may be useful to clinicians for predicting outcome and in clinical decision-making. The aim of this study was to evaluate the potential prognostic value of the apoptotic/survival-controlling proteins and protein tyrosine kinase ZAP-70 gene expression in CLL patients and control individuals, correlating such findings with patients' clinical data...
February 1, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28183683/study-of-cd4-cd8-and-natural-killer-cells-cd16-cd56-in-children-with-immune-thrombocytopenic-purpura
#2
Farida Hussein El-Rashedi, Mahmoud Ahmed El-Hawy, Mohamed Ahmed Helwa, Sameh Said Abd-Allah
OBJECTIVE/BACKGROUND: To assess the percentage of CD4(+), CD8(+), and natural killer cells (CD16(+), CD56(+)) in children with immune thrombocytopenic purpura (ITP) at presentation and study their impact on disease chronicity. METHODS: This case-control study was conducted at the Pediatric Hematology and Oncology Unit, Menoufia University Hospital (tertiary care center in Egypt). The study was held on 30 children presenting with ITP; they were followed-up and classified into two groups: 15 children with acute ITP; and 15 children with chronic ITP...
February 1, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28183682/synovial-sarcoma-of-the-hard-palate-the-third-case-in-the-medical-literature
#3
Aseel Doubi, Motaz Doubi, Nabil Al Zaher, Asma Tulbah
No abstract text is available yet for this article.
February 1, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28183681/relapse-of-hodgkin-lymphoma-after-autologous-transplantation-time-to-rethink-treatment
#4
REVIEW
Yogesh Jethava, Guru Subramanian Guru Murthy, Mehdi Hamadani
Relapse of Hodgkin lymphoma after autologous hematopoietic cell transplantation (autologous HCT) is a major therapeutic challenge. Its management, at least in younger patients, traditionally involves salvage chemotherapy aiming to achieve disease remission followed by consolidation with allogeneic hematopoietic cell transplantation (allogeneic HCT) in eligible patients. The efficacy of salvage therapy is variable and newer combination chemotherapy regimens have improved the outcomes. Factors such as shorter time to relapse after autologous HCT and poor performance status have been identified as predictors of poor outcome...
February 1, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28183680/diagnosis-of-variant-rara-translocation-using-standard-dual-color-dual-fusion-pml-rara-fish-probes-an-illustrative-report
#5
Manish Kumar Singh, Mayur Parihar, Neeraj Arora, Deepak Kumar Mishra, Saurabh Jayant Bhave, Mammen Chandy
Acute promyelocytic leukemia (APML) with variant RARa translocations comprises 1-2% of APML cases. However, the diagnosis of these cases is challenging as the routine practice includes fluorescence in situ hybridization (FISH) reverse transcription polymerase chain reaction targeting the PML and RARA genes to detect PML/RARA fusions. Here, we report a case highlighting the importance of atypical FISH signal patterns in standard dual-color dual-fusion PML/RARa FISH analysis complimented by karyotyping to detect these variant RARA translocations...
February 1, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28183679/glomangiopericytoma-hemangiopericytoma-of-the-maxillary-sinus-and-sinonasal-tract
#6
Samaher Al Saad, Razan Al Hadlaq, Nabil Al-Zaher
No abstract text is available yet for this article.
February 1, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28174010/a-case-of-t-cell-lymphoproliferative-disorder-associated-with-hypereosinophilia-with-excellent-response-to-mycophenolate-mofetil
#7
Amr Hanbali, Marwan Shaheen, Feras Alfraih, Wafa Al-Otaibi, Riad El Fakih, Tarek Owaidah, Syed Ahmed
Hypereosinophilic syndrome (HES) is a group of rare blood disorders characterized by a persistent elevation of blood eosinophil count ⩾1.5×10(9)/L and clinical manifestations attributable to eosinophilia or tissue hypereosinophilia. Lymphocytic variant of HES (HES-L) is a known subtype according to World Health Organization classification. It is well documented in the literature that patients with HES-L are predisposed to develop T-cell lymphoma. We report a case of T-cell lymphoproliferation associated with hypereosinophilia, which has been successfully treated with mycophenolate mofetil, with resolution of skin lesions and normalization of eosinophil count and immunoglobulin E level...
February 1, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/27614231/yield-of-computed-tomography-pulmonary-angiogram-in-the-emergency-department-in-cancer-patients-suspected-to-have-pulmonary-embolism
#8
Pierre Tannous, Zubin Mukadam, Chetan Kammari, Harsha Banavasi, Ayman O Soubani
OBJECTIVE/BACKGROUND: The use of computed tomography pulmonary angiography (CTPA) in the emergency department (ED) for patients suspected to have pulmonary embolism (PE) has been steadily rising in the last 2decades. However, there are limited studies that specifically address the use of CTPA in the ED for cancer patients suspected to have PE. The objective of this study is to assess the rate of positive PE by CTPA in the ED in cancer patients and the variables that are associated with positive results...
December 2016: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/27614228/myh9-related-disorder-a-probable-may-hegglin-anomaly-case-series-a-tertiary-care-experience
#9
Vandana Kamath, Kiruthiga Kala Gnanasekaran, Joy Mammen
OBJECTIVE/BACKGROUND: May-Hegglin anomaly (MHA) is a rare familial bleeding disorder characterized by a triad of thrombocytopenia, giant platelets, and Döhle-like inclusion bodies within the leukocytes. The clinical spectrum as well as the pathophysiology of this entity is not well defined. The objective of this work is to present a series of three cases of MHA diagnosed in our hospital, where the patients presented with variable bleeding manifestations, thrombocytopenia, and giant platelets...
December 2016: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/27613373/pre-operative-chemoradiotherapy-using-capecitabine-and-cetuximab-followed-by-definitive-surgery-in-patients-with-operable-rectal-cancer
#10
Shouki Bazarbashi, Ayman Omar, Ali Aljubran, Ahmad Alzahrani, Nasser Alsanea, Alaa Abduljabbar, Samar Alhomoud, Luai Ashari, Khalid Balaraj, Hussein Soudy, Mohammad Neimatallah, Musa Fagih
BACKGROUND: Achieving a high rate of complete pathological response with pre-operative chemoradiotherapy in rectal cancer is an unmet need. We evaluated the efficacy and toxicity of the combination of cetuximab, capecitabine and radiation therapy in the pre-operative setting of localized rectal cancer. PATIENTS AND METHODS: Patients with clinically staged T3, T4 or nodepositive rectal cancer were treated with concurrent capecitabine and radiotherapy with weekly cetuximab starting one week before the start of radiation...
December 2016: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/27521150/impact-of-conditioning-and-engraftment-on-iron-status-in-hematopoietic-stem-cell-transplantation-contribution-of-labile-plasma-iron
#11
Flávio Augusto Naoum, Breno Pannia Espósito, Rodolfo Delfini Cançado
No abstract text is available yet for this article.
December 2016: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/27352262/sustained-molecular-response-with-nilotinib-in-imatinib-intolerant-chronic-myeloid-leukaemia-with-an-e19a2-bcr-abl1-fusion
#12
Mireille Crampe, Jennifer Garry, Stephen E Langabeer, Philip T Murphy
No abstract text is available yet for this article.
December 2016: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/27352258/detection-of-t-8-14-c-myc-igh-gene-rearrangement-by-long-distance-polymerase-chain-reaction-in-patients-with-diffuse-large-b-cell-lymphoma
#13
Arezoo Kiaei, Habib Onsori, Aylar Alijani, Sasan Andalib, Saeid Ghorbian, Ebrahim Sakhinia
OBJECTIVE/BACKGROUND: Specific chromosomal translocations are found in human leukemias and lymphomas. These translocations are closely related to particular histological and immunological phenotypes. In Burkitt's lymphoma, translocation t(8;14)(q24;q32), which involves the c-myc gene (8q24) and the immunoglobulin heavy-chain (IgH) locus (14q32), accounts for 90-95% of all chromosomal translocations. This translocation can be found in 2-5% of diffuse large B-cell lymphoma (DLBCL). Long-distance polymerase chain reaction (LD-PCR) assays, which can identify oncogene/Ig gene rearrangement, can detect these fusion genes...
December 2016: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/27000549/dual-light-chain-extramedullary-myeloma-presenting-with-mediastinal-lymphadenopathy-and-lytic-bone-lesions
#14
Panagiotis J Vlachostergios, Katerina G Oikonomou, Adnan Hussain, Rakesh Abbi, Rajeev L Balmiki
No abstract text is available yet for this article.
December 2016: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/26845227/a-rare-case-of-familial-multiple-subcutaneous-lipomatosis-with-novel-palb2-mutation-and-increased-predilection-to-cancers
#15
Neelesh Reddy, Baswantrao Malipatil, Satish Kumar
We describe the association of familial multiple subcutaneous lipomatosis with a PALB2 gene mutation (c.2716delT) and its increased predilection to cancers.
December 2016: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/26684920/clotrimazole-troches-induce-supratherapeutic-blood-levels-of-sirolimus-and-tacrolimus-in-an-allogeneic-hematopoietic-cell-transplant-recipient-resulting-in-acute-kidney-injury
#16
Jessica El-Asmar, Rebecca Gonzalez, Ryan Bookout, Asmita Mishra, Mohamed A Kharfan-Dabaja
Allogeneic hematopoietic cell transplantation is a potential curative treatment option for various malignant and nonmalignant hematologic disorders. Patients undergoing an allogeneic hematopoietic cell transplant are prescribed immune-suppressant therapies to facilitate hematopoietic donor-cell engraftment and prevent graft-versus-host disease. Drug-drug interactions may occur, owing to exposure to complex multidrug regimens with narrow therapeutic windows and high toxicity profiles. Here, we describe a unique case of a 65-year-old man with poor-risk acute myeloid leukemia who underwent a matched-sibling hematopoietic cell allograft...
December 2016: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/27842210/prevalence-and-relative-proportions-of-cll-and-non-cll-monoclonal-b-cell-lymphocytosis-phenotypes-in-the-middle-eastern-population
#17
Mahmoud Aljurf, Faisal Rawas, Randa Alnounou, Nasir Bakshi, Naeem Chaudhri, Salem Khalil, Fahad Almohareb, Maher Albitar
No abstract text is available yet for this article.
November 9, 2016: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/27842209/vesicoileal-fistula-and-clostridium-difficile-colitis-in-a-child-with-acute-lymphoblastic-leukemia
#18
Maher Alainawi, Rouba Shaker, Aya Eltraboulsi, Samir Akel, Nadine Yazbeck, Hassan El Solh, Samar Muwakkit
No abstract text is available yet for this article.
November 9, 2016: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/27793578/diagnostic-value-of-sepsis-biomarkers-in-hematopoietic-stem-cell-transplant-recipients-in-a-condition-of-high-prevalence-of-gram-negative-pathogens
#19
Igor Stoma, Igor Karpov, Anatoly Uss, Oleg Rummo, Natalia Milanovich, Igor Iskrov
OBJECTIVE/BACKGROUND: A decision about the need for antimicrobial therapy in a patient with febrile neutropenia after hematopoietic stem cell transplantation (HSCT) is often complicated because of the low frequency of culture isolation and reduced clinical manifestation of infection. Usefulness and choice of sepsis biomarkers to distinguish bloodstream infection (BSI) from other causes of febrile episode is still argued in HSCT recipients in modern epidemiological situations characterized by the emergence of highly resistant gram-negative microorganisms...
October 20, 2016: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/27793577/a-novel-tnfrsf1a-gene-mutation-in-a-patient-with-tumor-necrosis-factor-receptor-associated-periodic-syndrome
#20
Alireza Khabazi, Mahafarin Maralani, Sasan Andalib, Ebrahim Sakhinia
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is a periodic fever syndrome inherited in an autosomal dominant fashion. It stems from mutations in the TNFRSF1A gene that expresses the receptor for tumor necrosis factor α. A patient with TRAPS may present with prolonged episodes of fever attacks, abdominal pain, severe myalgia, and painful erythema on the trunk or extremities. Here, we report the case of an 8-year-old boy with febrile attacks occurring every 1-2months and continuing for 3-4days...
October 19, 2016: Hematology/oncology and Stem Cell Therapy
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