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Hematology/oncology and Stem Cell Therapy

Ryo Hanajiri, Takeshi Kobayashi, Kosuke Yoshioka, Daisuke Watanabe, Kyoko Watakabe, Yutaka Murata, Takeshi Hagino, Yasushi Seno, Yuho Najima, Aiko Igarashi, Noriko Doki, Kazuhiko Kakihana, Hisashi Sakamaki, Kazuteru Ohashi
OBJECTIVE/BACKGROUND: Here, we described the clinical characteristics and outcomes of central nervous system (CNS) infections occurring after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in a single institution over the previous 6 years. METHODS: Charts of 353 consecutive allogeneic transplant recipients were retrospectively reviewed for CNS infection. RESULTS: A total of 17 cases of CNS infection were identified at a median of 38 days (range, 10-1028 days) after allo-HSCT...
September 17, 2016: Hematology/oncology and Stem Cell Therapy
Hossein Ayatollahi, Arezoo Shajiee, Mohammad Hadi Sadeghian, Maryam Sheikhi, Ehsan Yazdandoust, Masumeh Ghazanfarpour
OBJECTIVE/BACKGROUND: Acute myeloid leukemia (AML) is defined as leukemic blast reproduction in bone marrow. Chromosomal abnormalities form different subgroups with joint clinical specifications and results. t(8;21)(q22;q22) and inv(16)(p13;q22) form core binding factor-AML (CBF-AML). c-kit mutation activation occurs in 12.8-46.1% of adults with CBF leukemia. These mutations occur in 20-25% of t(8;21) and 30% of inv(16) cases. METHODS: In this systematic review, we searched different databases, including PubMed, Scopus, and Embase...
September 3, 2016: Hematology/oncology and Stem Cell Therapy
Iman Abou Dalle, Samer Nassif, Ali Bazarbachi
Pathologic increase in bone marrow reticulin fibrosis can be present in many malignant hematopoietic diseases. In acute leukemia, one-third of patients have some degree of marrow reticulin fibrosis at presentation, which is thought to be related to cytokine release from blasts. Marrow fibrosis is particularly common in acute megakaryoblastic leukemia, while this change is rarely seen in acute promyelocytic leukemia. Six case reports of acute promyelocytic leukemia with marrow reticulin fibrosis have been described so far in the literature...
September 2, 2016: Hematology/oncology and Stem Cell Therapy
Pierre Tannous, Zubin Mukadam, Chetan Kammari, Harsha Banavasi, Ayman O Soubani
OBJECTIVE/BACKGROUND: The use of computed tomography pulmonary angiography (CTPA) in the emergency department (ED) for patients suspected to have pulmonary embolism (PE) has been steadily rising in the last 2decades. However, there are limited studies that specifically address the use of CTPA in the ED for cancer patients suspected to have PE. The objective of this study is to assess the rate of positive PE by CTPA in the ED in cancer patients and the variables that are associated with positive results...
September 2, 2016: Hematology/oncology and Stem Cell Therapy
Shweta Kambali, Asma Taj
Polycythemia vera is one of the chronic myeloproliferative diseases and very few patients present with its actual clinical manifestations. The most common findings are increased red cell mass and an increased leukocyte count with decreased erythropoietin. We present a case where there was a delay in the diagnosis of polycythemia because of menorrhagia in the past. On admission, the patient presented with elevated red and white blood cell counts, erythropoietin was low, and polycythemia was then suspected. A bcr-abl test was performed to rule out chronic myelogenous leukemia...
September 2, 2016: Hematology/oncology and Stem Cell Therapy
Stephen E Langabeer, Karl Haslam
No abstract text is available yet for this article.
September 2, 2016: Hematology/oncology and Stem Cell Therapy
Vandana Kamath, Kiruthiga Kala Gnanasekaran, Joy Mammen
OBJECTIVE/BACKGROUND: May-Hegglin anomaly (MHA) is a rare familial bleeding disorder characterized by a triad of thrombocytopenia, giant platelets, and Döhle-like inclusion bodies within the leukocytes. The clinical spectrum as well as the pathophysiology of this entity is not well defined. The objective of this work is to present a series of three cases of MHA diagnosed in our hospital, where the patients presented with variable bleeding manifestations, thrombocytopenia, and giant platelets...
September 2, 2016: Hematology/oncology and Stem Cell Therapy
Shouki Bazarbashi, Ayman Omar, Ali Aljubran, Ahmad Alzahrani, Nasser Alsanea, Alaa Abduljabbar, Samar Alhomoud, Luai Ashari, Khalid Balaraj, Hussein Soudy, Mohammad Nematallah, Musa Fagih
BACKGROUND: Achieving a high rate of complete pathological response with pre-operative chemoradiotherapy in rectal cancer is an unmet need. We evaluated the efficacy and toxicity of the combination of cetuximab, capecitabine and radiation therapy in the pre-operative setting of localized rectal cancer. PATIENTS AND METHODS: Patients with clinically staged T3, T4 or nodepositive rectal cancer were treated with concurrent capecitabine and radiotherapy with weekly cetuximab starting one week before the start of radiation...
September 2, 2016: Hematology/oncology and Stem Cell Therapy
Flávio Augusto Naoum, Breno Pannia Espósito, Rodolfo Delfini Cançado
No abstract text is available yet for this article.
August 6, 2016: Hematology/oncology and Stem Cell Therapy
Sawsan Amireh, Hamid Shaaban, Gunwant Guron
Malaria-related hemophagocytic lymphohistiocytosis is a rare, potentially fatal, hyperinflammatory disease entity which can be challenging to diagnose and treat. It is usually associated with Plasmodium falciparum infection. It is less frequently associated with Plasmodium vivax. Here we report an unusual case of a 23-year-old healthy Nigerian man who presented with fever, microangiopathic hemolytic anemia, acute renal failure, and confusion, and was diagnosed as having cerebral malaria-related hemophagocytic lymphohistiocytosis caused by P...
August 6, 2016: Hematology/oncology and Stem Cell Therapy
Marco Pizzi, Usama Gergis, Felicia Chaviano, Attilio Orazi
BACKGROUND/OBJECTIVE: Hematopoietic stem cell transplant (HSCT) is the only curative treatment for myeloproliferative neoplasm-associated myelofibrosis (MPN-MF). The main clinical manifestation of MPN-MF is splenomegaly secondary to extramedullary hematopoiesis (EMH). The effects of HSCT on splenic EMH and associated vascular and stromal changes are unknown. This study compares the findings seen in spleens following HSCT with those of nontransplanted patients, normal controls, and matched bone marrow (BM) samples...
September 2016: Hematology/oncology and Stem Cell Therapy
Karl Haslam, Eibhlin Conneally, Catherine M Flynn, Mary R Cahill, Oonagh Gilligan, Derville O'Shea, Stephen E Langabeer
Insertion and/or deletion mutations of the CALR gene have recently been demonstrated to be the second most common driver mutations in the myeloproliferative neoplasms (MPNs) of essential thrombocythemia (ET) and primary myelofibrosis (PMF). Given the diagnostic and emerging prognostic significance of these mutations, in addition to the geographical heterogeneity reported, the incidence of CALR mutations was determined in an Irish cohort of patients with MPNs with a view to incorporate this analysis into a prospective screening program...
September 2016: Hematology/oncology and Stem Cell Therapy
David A Sallman, Eric Padron
Hematologic myeloid neoplasms represent a heterogeneous group of disorders with defined clinical and pathologic characteristics. However, intensive investigation into the genetic abnormalities of these diseases has not only significantly advanced our understanding, but also revolutionized our diagnostic and prognostic capabilities. Moreover, more recent discovery on the impact of clonal burden has highlighted the critical and dynamic role of clonal evolution over time, which is integrally linked to a patient's clinical trajectory...
September 2016: Hematology/oncology and Stem Cell Therapy
Matthew Rinehart, Erica Hochard, Michelle Rockey, Sunil Abhyankar, Siddhartha Ganguly, Tara Lin, Joseph McGuirk, Leyla Shune, Anurag Singh, Omar Aljitawi
OBJECTIVE/BACKGROUND: Cytomegalovirus (CMV) causes significant morbidity and mortality in CMV seropositive patients undergoing umbilical cord blood transplants (UCBT). Our study aimed to describe the incidence of CMV reactivation and burden of disease, as well as the tolerability of an intensive prevention strategy as compared to historical prevention. METHODS: This was a retrospective chart review of 33 CMV seropositive patients that underwent UCBT. The intensive prevention strategy in UCBT consisted of ganciclovir 5mg/kg/d intravenously or valganciclovir 900mg by mouth daily initiated at the beginning of the conditioning regimen until Day -2...
September 2016: Hematology/oncology and Stem Cell Therapy
Ohoud Alotaibi, Nabil Al-Zaher, Faiza Alotaibi, Hatim Khoja, Ahmed Qannam
Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare malignant neoplasm that has an exquisitely exclusive affection to the jawbone. It is defined as squamous cell carcinoma arising within the jaw and developing from residual odontogenic epithelium or from a preexisting odontogenic cyst or tumor. The solid-type of this tumor is a central jaw carcinoma arising de novo and has no initial connection with the oral mucosa. Herein, we report a case of solid-type PIOSCC involving the mandible in a 37-year-old male patient elucidating its histopathological and imaging findings...
September 2016: Hematology/oncology and Stem Cell Therapy
Assem A Elghazaly, Mamoun H Ibrahim, Layla A AlGwaiz
We are presenting a case of an adult male patient with monocytic acute myeloid leukemia (AML) who had on presentation brain infarction and bilobed nuclei had been demonstrated in many of the leukemic blasts. There was no laboratory evidence of acute disseminated intravascular coagulopathy, on presentation or later on. Initially the diagnosis of acute promyelocytic leukemia (APL) was considered, so all trans-retinoic acid (ATRA) was added to induction chemo therapy. As the diagnosis of APL was ruled out, based on the flow cytometry, fluorescent in situ hybridization and polymerase chain reaction findings, the ATRA was discontinued and the patient continued on the standard AML chemo therapy induction regimen...
September 2016: Hematology/oncology and Stem Cell Therapy
Syed Z A Zaidi, Ibraheem H Motabi, Ali Al-Shanqeeti
Neural cell adhesion molecule (NCAM/CD56) expression in acute myeloid leukemia (AML) has been associated with extramedullary leukemia, multidrug resistance, shorter remission and survival. Recently, Bloomfield et al. published a succinct review of issues surrounding the AML prognostication and current therapeutics. However, we want to reiterate the prognostic value and therapeutic potential of CD56 that is frequently expressed in AML as was also reported by their own group earlier. In addition, novel RUNX1 isoforms contribute in controlling CD56 expression in AML cells...
September 2016: Hematology/oncology and Stem Cell Therapy
Faris Madanat, Hiba Jaber, Ismaeel Azayyat, Nazmi Kamal, Fareed Barakat, Khaldoun Al-Kayed, Rawad Rihani
No abstract text is available yet for this article.
September 2016: Hematology/oncology and Stem Cell Therapy
Housam Haddad, Manida Wungjiranirun, Usama Gergis
We describe the first case of a FLT-3 mutated AML in a healthy donor, 3years after recombinant human granulocyte colony stimulating factor (rhG-CSF)-mobilized peripheral blood stem cell (PBSC) harvest. The patient had a myeloablative (MA) matched unrelated donor (MUD) stem cell transplant (SCT) for refractory AML. However, he experienced a secondary graft failure. He had a second non myeloablative (NMA) on day +75 from a second MUD. He achieved a complete neutrophil and platelet engraftment. After 4years of follow up, he is alive in complete remission with full second donor chimerism...
September 2016: Hematology/oncology and Stem Cell Therapy
Ahmad Alhuraiji, Nitin Jain
No abstract text is available yet for this article.
June 23, 2016: Hematology/oncology and Stem Cell Therapy
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