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Hematology/oncology and Stem Cell Therapy

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https://www.readbyqxmd.com/read/28867175/thrombo-hemorrhagic-liability-in-children-with-congenital-heart-diseases
#1
REVIEW
Shebl Said Shebl, Walid Ahmed Naguib El-Shehaby, Amira Hamed Darwish, Yasmin Shebl Said, Nabeh Helal Elfadaly, Eman Amer
BACKGROUND: The precise mechanisms of the increased incidence of hemostatic abnormalities in congenital heart disease (CHD) have not been determined. The aim of the study was to evaluate some indicators of activation of platelets and vascular endothelial cells in patients with CHD, evaluation of bleeding liability of these patients, and correlation with the clinical presentation of these patients. METHODS: This work was carried out on 20 patients with cyanotic congenital heart disease (CCHD), 20 patients with cyanotic congenital heart disease (ACHD), and 20 healthy children who served as the control group, aged between 1 and 10years...
August 26, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28837784/relevance-of-bone-marrow-transplantation-nursing-training-program-at-king-faisal-specialist-hospital-and-research-centre-for-national-and-regional-nurses
#2
REVIEW
Reguia Belkhedim
No abstract text is available yet for this article.
August 18, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28834695/multimodality-therapy-improves-survival-in-intramedullary-spinal-cord-metastasis-of-lung-primary
#3
Hayder Saeed, Reema Patel, Jigisha Thakkar, Lames Hamoodi, Li Chen, John Villano
BACKGROUND: Most metastatic spinal cord lesions are located either in the intradural, extramedullary, or in the epidural compartments. Intramedullary spinal cord metastasis (ISCM) is a rare central nervous system spread of cancer. The aim of this report was to evaluate ISCM in the published literature. METHODS: A literature review of PubMed from 1960 to 2016 was undertaken for the publications having demographic, clinical, histological, and outcome data. RESULTS: A total of 59 relevant papers were identified, showing 128 cases of intramedullary metastasis from lung cancer...
August 16, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28834694/ruxolitinib-for-secondary-hemophagocytic-lymphohistiocytosis-first-case-report
#4
Jonathan H Sin, Mark L Zangardi
Hemophagocytic lymphohistiocytosis (HLH) is an immune-mediated disorder resulting in hyper-activation of inflammatory cytokines. If left untreated, the uncontrolled inflammatory response can lead to significant tissue injury and potentially life-threatening multi-organ dysfunction. Conventional immunosuppressive agents are available for the management of HLH, including dexamethasone, cyclosporine, and etoposide; however, patients may not respond to these therapies. Clinicians may turn toward alternative pharmacologic agents that likely have less clinical evidence...
August 16, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28830803/acute-promyelocytic-leukemia-in-a-patient-with-chronic-lymphocytic-leukemia-a-case-report
#5
Prajwal Boddu, Ellen Schlette, Beenu Thakral, Guillin Tang, Naveen Pemmaraju, Tapan Kadia, Alessandra Ferrajoli, Farhad Ravandi, William Wierda, Nitin Jain
Chronic lymphocytic leukemia (CLL) is known to be associated rarely with myeloid malignancies such as acute myelogenous leukemia. In this article, we report an extremely rare occurrence of acute promyelocytic leukemia in a patient with CLL. A 71-year-old man first presented to our clinic with a diagnosis of CLL and worsening motor neuropathy symptoms. It was suspected that his CLL might be contributing to the neuropathy as a paraneoplastic syndrome, and he was treated with rituximab monotherapy in weekly doses for the 1st month and monthly treatments thereafter...
August 16, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28830802/impact-of-vitamin-d-deficiency-on-increased-blood-eosinophil-counts
#6
João Tadeu Damian Souto Filho, Alícia Souza de Andrade, Felipe Mesquita Ribeiro, Paola de Araujo Sardenberg Alves, Virgínia Ribeiro Fernandes Simonini
OBJECTIVE/BACKGROUND: Vitamin D has been increasingly recognized as an immunomodulatory agent. Its deficiency has been associated with immune-mediated diseases such as asthma, rhinitis, and atopic dermatitis. These allergic conditions are dependent on T-helper type 2 (Th2) cells secreting interleukins, overproduction of immunoglobulin E (IgE), and eosinophil activation. We investigated the association between serum vitamin D levels and blood absolute eosinophil count. METHODS: We carried out a cross-sectional study of 669 men and women referred to a clinical pathology laboratory who underwent 25-hydroxyvitamin D testing and complete blood count analysis on the same day...
August 16, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28830801/presence-of-fluorescent-in-situ-hybridization-abnormalities-is-associated-with-plasma-cell-burden-in-light-chain-amyloidosis
#7
Lindsay Hammons, Ruta Brazauskas, Marcelo Pasquini, Mehdi Hamadani, Parameswaran Hari, Anita D'Souza
OBJECTIVE/BACKGROUND: To assess abnormalities found on CD138-enriched fluorescent in situ hybridization (FISH) studies on pretreated bone marrow in systemic amyloid light-chain (AL) amyloidosis and correlate findings between these abnormalities with organ involvement and 1-year survival. METHODS: We reviewed 107 patients with systemic AL to identify the impact of a diagnostic FISH study done on plasma cell clones in our institution between January 2010 and January 2015; 77 had pretreatment testing performed...
August 16, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28755838/hematopoietic-stem-cell-transplantation-in-pakistan-country-report
#8
REVIEW
Parvez Ahmed, Tahir Sultan Shamsi, Salman Naseem Adil, Tariq Mahmood Satti, Qamar Un Nisa Chaudhry, Syed Kamran Mahmood, Kamran Rashid, Saqib Ansari, Natasha Ali, Tariq Ghafoor
No abstract text is available yet for this article.
July 22, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28751034/current-concepts-on-hematopoietic-stem-cell-transplantation-outcome-registries-emphases-on-resource-requirements-for-new-registries
#9
REVIEW
Fazal Hussain, Naeem Chaudhri, Feras Alfraih, Mahmoud Aljurf
There is tremendous variability in size, scope, and resource requirements for registries depending on the number of patients and participating sites. The outcome registries are organized systems to collect uniform data using an observational study methodology. Patient registries are used to determine specified outcomes for a population for predetermined scientific, clinical, or policy purposes. Historically, outcome registries established in the development of hematopoietic stem cell transplantation (HSCT) have now evolved into myriads of locoregional and international transplant activity and outcome resources...
July 19, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28732192/cost-and-quality-issues-in-establishing-hematopoietic-cell-transplant-program-in-developing-countries
#10
REVIEW
Shahrukh K Hashmi, Alok Srivastava, Walid Rasheed, Salman Adil, Tong Wu, Madan Jagasia, Amr Nassar, William Y K Hwang, Amir Ali Hamidieh, Hildegard T Greinix, Marcelo C Pasquini, Jane F Apperley, Mahmoud Aljurf
The hematopoietic cell transplant (HCT) activity has grown significantly over the past two decades in both developing and developed countries. Many challenges arise in establishing new HCT programs in developing countries, due to scarcity of resources and manpower in expertise in HCT. While cost issues can potentially hinder establishment of new HCT programs in certain regions, the focus on quality and value should be included in the general vision of leadership before establishing an HCT program. The main challenge in most developing countries is the lack of trained/qualified personnel, enormous start-up costs for a tertiary care center, and quality maintenance...
July 14, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28711452/hematopoietic-stem-cell-transplantation-in-algeria
#11
REVIEW
Mohamed Amine Bekadja, Mohamed Brahimi, Soufi Osmani, Nabil Yafour, Amina Krim, Faiza Serradj, Souad Talhi, Kamila Amani, Rachid Amar Bouhass
INTRODUCTION: Algeria is a country of 40,.4 million inhabitants and half of which is under 30years. In Algeria, Health-care insurance covered, 90% of the population. Health care is free and it is supported by the Ministry of Health. 16 university hospitals exist in Algeria and only two (Algiers and Oran) practicing bone marrow transplant. Adult hematologic malignancies account for 10% (about 4000 new cases/year) of the malignancy affecting in most cases young patients under 65years of age...
July 11, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28700895/plasmablastic-lymphoma-presenting-as-exophytic-skin-lesions
#12
Riad El Fakih, Muhamad Almahayni, Maamoun Alsermani
No abstract text is available yet for this article.
July 5, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28692818/establishing-an-autologous-versus-allogeneic-hematopoietic-cell-transplant-program-in-nations-with-emerging-economies
#13
REVIEW
Naeem A Chaudhri, Mahmoud Aljurf, Fahad I Almohareb, Hazzaa A Alzahrani, Qaiser Bashir, Bipin Savani, Vikas Gupta, Shahrukh K Hashmi
More than 70,000 hematopoietic cell transplants are currently performed each year, and these continue to increase every year. However, there is a significant variation in the number of absolute transplants and transplant rates between centers, countries, and global regions. The prospect for emerging countries to develop a hematopoietic cell transplantation (HCT) program, as well as to decide on whether autologous HCT (auto-HCT) or allogeneic HCT (allo-HCT) should be established to start with, relies heavily on factors that can explain differences between these two procedures...
July 3, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28692817/complications-of-hematopoietic-stem-transplantation-bacterial-infections
#14
REVIEW
Ali S Omrani, Reem S Almaghrabi
Bacterial infections remain a common complication of hematopoietic stem cell transplantation (HSCT), especially in the pre-engraftment phase. The risk of bacterial infections is mainly related to neutropenia, mucositis, and the presence of vascular lines. Most parts of the world have witnessed a shift in epidemiology toward Gram-negative bacteria; a large proportion of which are resistant to fluoroquinolones, extended-spectrum beta-lactams, carbapenems, and in some units even colistin. Meticulous infection control practices are essential for prevention of bacterial infections in HSCT...
July 3, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28686878/current-indication-for-hematopoietic-cell-transplantation-in-adults
#15
REVIEW
Shinichiro Okamoto
With advances in transplantation technology and supportive care practices, hematopoietic cell transplantation (HCT) has become relatively safer and the applicability of HCT continues to expand. However, appropriate selection of transplant candidates remains challenging. Identifying adult patients who may benefit from HCT involves consideration of patient and disease factors, including overall health, prior therapies, age, comorbidity, and disease/disease risk. The eligibility of transplants should be decided on a case by case basis, based upon a risk-benefit assessment...
June 30, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28686879/hematopoietic-stem-cell-transplantation-in-qatar-one-year-anniversary
#16
REVIEW
Mohammad Bakr, Ibrahim Al-Hijji, Naziha Menasria, Zeyd Merenkov, Safaa Al-Azzawi, Ruba Taha, Amaal Gulied, Catherine Anne Gillespie, Said Dermime, Effie Liakopoulou, Alexander Knuth
Hematopoietic stem cell transplantation (HSCT) offers potentially curative therapy for many hematologic and nonhematologic conditions. As a successful outcome of Qatar's National Cancer Strategy, the HSCT program was started in the National Center for Cancer Care and Research (NCCCR) in October 2015. The HSCT program in NCCCR is the only transplant program in Qatar and self-sufficient with all three core components: the stem cell collection facility, the stem cell processing facility, and the clinical program, which are locally available at Hamad Medical Corporation...
June 29, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28683254/practical-implementation-essential-elements-resource-tool
#17
REVIEW
Nina Worel
Hematopoietic stem cell transplantation (HSCT) is an established treatment for patients with severe congenital or acquired hemato-/oncological disorders. Despite major improvements, HSCT remains associated with substantial morbidity and mortality. Implementation of a quality management system has become standard practice not only for industries when their products or services are associated with significant risks to human safety but also in the healthcare sector. The use of a quality management system contributes to better products and services and improved patient's outcome after medical interventions...
June 29, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28683255/nursing-challenges-caring-for-bone-marrow-transplantation-patients-with-graft-versus-host-disease
#18
REVIEW
Joyce Neumann
No abstract text is available yet for this article.
June 28, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28666103/kuwait-bone-marrow-transplantation-activities
#19
REVIEW
Salem H Alshemmar, Reem Ameen
Kuwait is located in the Arabian Gulf and has a population of 3.5million. The stem cell transplantation program started in 2000. Autologous peripheral blood stem cell transplantation started first, as it was easier technically to establish. In 2011, the allogeneic program started with focus on acute leukemia and hemoglobinopathies. The success of both programs required teamwork and support of health planners. We are in the process of establishing a bone marrow donor registry. The issue of donor availability and drug shortage remain the two main obstacles for expanding the bone marrow transplantation program...
June 22, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28666104/hematopoietic-cell-transplantation-in-hematological-malignancies-hematopoietic-cell-transplantation-in-acute-myeloid-leukemia
#20
REVIEW
Adetola Kassim, Bipin N Savani
Increasing numbers of patients are receiving allogeneic hematopoietic cell transplantation (HCT) for acute myeloid leukemia (AML). Scientific and clinical advances in supportive care, donor selection, and conditioning regimens have resulted in lower transplant-related mortality, extension of care to a wider population of patients, and improvements in survival. Recent era has witnessed an explosive information about the molecular pathophysiology of AML. By early identification of patients at a high risk of relapse, it is expected that a majority of eligible patients will receive HCT in first complete remission...
June 20, 2017: Hematology/oncology and Stem Cell Therapy
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