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Acta Ophthalmologica

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https://www.readbyqxmd.com/read/28493461/ophthalmic-nepafenac-use-in-the-netherlands-and-denmark
#1
Andrea V Margulis, Eline Houben, Jesper Hallas, Jetty A Overbeek, Anton Pottegård, Tobias Torp-Pedersen, Susana Perez-Gutthann, Alejandro Arana
PURPOSE: To describe nepafenac use in the Netherlands and Denmark with reference to its approved indications. For context, we also describe the use of ketorolac and diclofenac. METHODS: We identified users in the PHARMO Database Network (the Netherlands, 2008-2013) and the Danish national health registers (Denmark, 1994-2014). We described prevalence of cataract surgery and duration of use in patients with cataract surgery with and without diabetes. RESULTS: In the Netherlands, 9530 nepafenac users (mean age, 71 years; 60% women) contributed 12 691 therapy episodes, of which 21% had a recently recorded cataract surgery...
May 10, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28481050/anisometropia-of-spherical-equivalent-and-astigmatism-among-myopes-a-23-year-follow-up-study-of-prevalence-and-changes-from-childhood-to-adulthood
#2
Olavi Pärssinen, Markku Kauppinen
PURPOSE: To study anisometropia of spherical equivalent and astigmatism from the onset of myopia at school age to adulthood. METHODS: A total of 240 myopic schoolchildren (mean age 10.9 years), with no previous spectacles, were recruited during 1983-1984 to a randomized 3-year clinical trial of bifocal treatment of myopia. Examinations with subjective cyclopedic refraction were repeated 3 years later (follow-up 1) for 238 subjects and thereafter at the mean ages of 23...
May 8, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28481040/optical-coherence-tomography-morphology-and-evolution-in-cblc-disease-related-maculopathy-in-a-case-series-of-very-young-patients
#3
Giacomo M Bacci, Maria A Donati, Elisabetta Pasquini, Francis Munier, Catia Cavicchi, Amelia Morrone, Andrea Sodi, Vittoria Murro, Nuria Garcia Segarra, Claudio Defilippi, Leonardo Bussolin, Roberto Caputo
PURPOSE: To describe the retinal structure of a group of patients affected by methylmalonic aciduria with homocystinuria cblC type, caused by mutations in the MMACHC gene, using spectral domain optical coherence tomography (SD-OCT). METHODS: Young patients (n = 11, age 0-74 months) with cblC disease, detected by newborn screening or clinically diagnosed within 40 days of life, underwent molecular analysis and complete ophthalmic examination, including fundus photography and SD-OCT...
May 8, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28481010/dynamics-of-big-bubble-formation-in-deep-anterior-lamellar-keratoplasty-by-the-big-bubble-technique-in%C3%A2-vitro-studies
#4
Harminder S Dua, Lana A Faraj, Mohamed B Kenawy, Saief AlTaan, Mohamed S Elalfy, Tarek Katamish, Dalia G Said
PURPOSE: To examine the movement of air injected in the cornea in simulated deep anterior lamellar keratoplasty (DALK), from the needle tip to the formation of different types of big bubbles (BB) and to ascertain how air travels through the stroma and pre-Descemet's layer [Dua's layer (PDL)] to create a type-1 (air between PDL and deep stroma) and type-2BB (air between PDL and Descemet's membrane). METHODS: Air was injected in 57 sclerocorneal discs and the passage recorded...
May 8, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28470954/systemic-intravenous-abciximab-a-novel-treatment-for-acute-central-retinal-artery-occlusion
#5
LETTER
José Ferreira Mendes, José Amorim, Gil Calvão-Santos
No abstract text is available yet for this article.
May 4, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28470942/influence-of-scanning-area-on-choroidal-vascularity-index-measurement-using-optical-coherence-tomography
#6
Rupesh Agrawal, Xin Wei, Abhilash Goud, Kiran Kumar Vupparaboina, Soumya Jana, Jay Chhablani
PURPOSE: Recently, choroidal vascularity index (CVI) is proposed as a novel tool to evaluate the choroidal vasculature. In this study, we investigate the impact of scanning area on CVI measurement using spectral-domain optical coherence tomography (SD-OCT). METHODS: Spectral-domain optical coherence tomography (SD-OCT) using enhanced depth imaging mode was performed in 30 eyes from 15 normal subjects. Three scanning areas were compared: dingle foveal scan; central macular scans [scan passing through central 1000 microns circle on Early Treatment Diabetic Retinopathy Study (ETDRS) grid, inner circle]; and total macular cube scans...
May 4, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28456139/visual-outcomes-of-polypoidal-choroidal-vasculopathy-treated-with-intravitreal-ranibizumab-with-or-without-photodynamic-therapy
#7
LETTER
Colin S Tan, Wei Kiong Ngo, Louis W Lim
No abstract text is available yet for this article.
April 29, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28449300/the-effect-of-canaloplasty-with-suprachoroidal-drainage-combined-with-cataract-surgery-1-year-results
#8
Anna-Maria Seuthe, Kai Januschowski, Siegfried Mariacher, Martina Ebner, Natalia Opitz, Peter Szurman, Karl Boden
PURPOSE: The purpose of this study was to investigate the safety and efficacy of phacocanaloplasty with suprachoroidal drainage (PCscD) and to compare its intraocular pressure (IOP)-lowering and drug-sparing effect to canaloplasty with suprachoroidal drainage (CscD). METHODS: The study retrospective interventional study included patients with open-angle glaucoma or secondary forms of glaucoma who underwent either CscD or PCscD between the year 2011 and 2014 in Knappschaft Eye Clinic Sulzbach...
April 27, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28444950/optical-coherence-tomography-evaluation-of-patients-with-macula-off-retinal-detachment-after-different-postoperative-posturing-a-randomized-pilot-study
#9
Enrico Peiretti, Francesco Nasini, Elisa Buschini, Giulia Caminiti, Sarit Y Lesnik Oberstein, Alissa Willig, Heico M Bijl, Marco Mura
PURPOSE: To assess the presence of outer and inner retinal folds (RFs) and drop-out of the ellipsoid zone (EZ) occurring after surgical repair of macula-off rhegmatogenous retinal detachment (RRD) with different postoperative posture and preoperative use of adjuvant perfluorocarbon liquid (PFCO). METHODS: In this prospective study, 56 eyes of 56 consecutive patients affected by RRD were subjected to 23- or 25-gauge pars plana vitrectomy (PPV). The patients were randomized in four groups (14 prone 5 hr without PFCO, 14 supine 5 hr without PFCO, 14 prone 5 hr with PFCO and 14 supine 5 hr with PFCO) and followed up with spectral domain optical coherence tomography (SD-OCT)...
April 26, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28444929/antiretinal-antibodies-in-central-serous-chorioretinopathy-prevalence-and-clinical-implications
#10
Josianne C E M Ten Berge, Elon H C van Dijk, Marco W J Schreurs, Jacolien Vermeer, Camiel J F Boon, Aniki Rothova
PURPOSE: To investigate the possible role of autoimmune reactions directed against retinal tissue in central serous chorioretinopathy (CSC), by analysing the presence of serum antiretinal antibodies (ARAs) and establishing their clinical relevance. METHODS: Sixty-three patients with CSC were included, and clinical characteristics were collected. Serum samples of all patients with CSC, 101 uveitis patients and 60 healthy donors were analysed for the presence of ARAs by indirect immunofluorescence...
April 26, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28444895/intraocular-pressure-following-intrastromal-corneal-ring-segments
#11
LETTER
Paula Arribas-Pardo, Carmen Mendez-Hernandez, Ricardo Cuiña-Sardiña, Jose Manuel Benitez-Del-Castillo, Julian Garcia-Feijoo
No abstract text is available yet for this article.
April 26, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28444874/prognostic-impact-of-chromosomal-aberrations-and-gnaq-gna11-and-bap1-mutations-in-uveal-melanoma
#12
Kjersti M Staby, Karsten Gravdal, Sverre J Mørk, Steffen Heegaard, Olav K Vintermyr, Jørgen Krohn
PURPOSE: To evaluate clinico-pathological and molecular prognostic factors in a well-defined series of posterior uveal melanoma (UM) with focus on chromosomal aberrations and mutations in the GNAQ, GNA11 and BRCA1-associated protein 1 (BAP1) genes. METHODS: Formalin-fixed paraffin-embedded (FFPE) tissue samples were obtained from 50 consecutive eyes enucleated for UM between 1993 and 2005. The material was tested for loss of chromosome 3 and gain of chromosome 8q gene signatures by selective molecular gene markers using multiplex ligation-dependent probe amplification (MLPA), and for DNA mutations in the GNAQ, GNA11 and BAP1 genes...
April 26, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28444837/prevalence-and-risk-factors-for-diabetic-retinopathy-in-17%C3%A2-152-patients-from-the-island-of-funen-denmark
#13
Morten B Larsen, Jan Erik Henriksen, Jakob Grauslund, Tunde Peto
PURPOSE: This study aims to estimate the prevalence and risk factors of diabetic retinopathy (DR) in patients enrolled in a large Danish quality-assuring database for diabetes: the Funen Diabetes Database (FDDB). METHODS: All patients with type 1 (T1DM) and type 2 DM (T2DM) diabetes mellitus (DM) were included in a cross-sectional study. The level of DR per patient was determined based on the eye with highest level of DR. All ocular and non-ocular data were extracted at the latest examination that corresponded to the most recent DR-grading data...
April 26, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28444824/a-comparison-between-patients-with-epiphora-and-cataract-of-the-activity-limitations-they-experience-in-daily-life-due-to-their-visual-disability
#14
Elin Bohman, Maria Wyon, Mats Lundström, Eva Dafgård Kopp
PURPOSE: The objective of this study was to compare patients with epiphora and cataract in terms of the activity limitations they experience in daily life due to their visual disability and to validate the use of the Catquest-9SF questionnaire for epiphora patients. METHODS: Seventy-two consecutively encountered adult patients with confirmed lacrimal obstruction and listed for dacryocystorhinostomy (DCR) or lacrimal intubation at the St. Erik Eye Hospital, Stockholm, Sweden, completed the Catquest-9SF questionnaire, which measures activity limitations in daily life due to visual disability...
April 26, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28440591/imaging-collector-channel-entrance-with-a-new-intraocular-micro-probe-swept-source-optical-coherence-tomography
#15
Chen Xin, Xiaoya Chen, Meng Li, Yan Shi, Huaizhou Wang, Ruikang Wang, Ningli Wang
PURPOSE: To describe the use of a newly developed side-viewing catheter probe to provide the cross-sectional images of collector channel entrance (CCE), achieved by swept-source optical coherence tomography (SS-OCT). METHODS: A side-viewing SS-OCT catheter probe was developed that has a core probe diameter of 0.15 mm and an outer diameter of 0.25 mm, for the purpose of imaging CCEs within eye globe. Cadaver eyes harvested from swine and human were used to demonstrate its feasibility...
April 25, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28440583/topical-antibiotics-and-intravitreal-injections
#16
REVIEW
Alex P Hunyor, Rohan Merani, Archie Darbar, Jean-François Korobelnik, Paolo Lanzetta, Annabelle A Okada
There is increasing evidence that topical antibiotics, given before and/or after intravitreal injections, are ineffective in preventing endophthalmitis and are possibly harmful. In addition to the lack of efficacy and increased development of resistant organisms, the use of topical antibiotics adds significantly to the cost of delivering intravitreal therapy. Despite this, in many countries, it is still common practice to use pre- and/or postinjection topical antibiotics. This review outlines the general principles of effective antibiotic prophylaxis, and the evidence regarding topical antibiotic use as a prophylactic measure for endophthalmitis following intravitreal injections...
April 25, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28391660/differential-expression-and-localization-of-human-tissue-inhibitors-of-metalloproteinases-in-proliferative-diabetic-retinopathy
#17
Ahmed M Abu El-Asrar, Ajmal Ahmad, Emilie Bittoun, Mohammad Mairaj Siddiquei, Ghulam Mohammad, Ahmed Mousa, Gert De Hertogh, Ghislain Opdenakker
PURPOSE: Tissue inhibitors of metalloproteinases (TIMPs) block the catalysis by matrix metalloproteinases (MMPs) and have additional biologic activities, including regulation of cell growth and differentiation, apoptosis, angiogenesis and oncogenesis. We investigated the expression levels of all the four human TIMPs and correlated these levels with those of MMP-9 and vascular endothelial growth factor (VEGF) in proliferative diabetic retinopathy (PDR). METHODS: Vitreous samples from 38 PDR and 21 nondiabetic control patients and epiretinal membranes from 14 patients with PDR and 10 patients with proliferative vitreoretinopathy (PVR) were studied by enzyme-linked immunosorbent assay, Western blot analysis and immunohistochemistry...
April 9, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28391655/topographic-analysis-of-eyelid-position-using-digital-image-processing-software
#18
Yeoun Sook Chun, Hong Hyun Park, In Ki Park, Nam Ju Moon, Sang Joon Park, Jeong Kyu Lee
PURPOSE: To propose a novel analysis technique for objective quantification of topographic eyelid position with an algorithmatically calculated scheme and to determine its feasibility. METHODS: One hundred normal eyelids from 100 patients were segmented using a graph cut algorithm, and 11 shape features of eyelids were semi-automatically quantified using in-house software. To evaluate the intra- and inter-examiner reliability of this software, intra-class correlation coefficients (ICCs) were used...
April 9, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28391654/preliminary-study-of-a-controllable-device-for-subtenon-drug-infusion-in-a-rabbit-model
#19
Yiqin Duan, Yezhen Yang, Xuetao Huang, Ding Lin
BACKGROUND AND OBJECTIVE: Conventional methods to treat intraocular diseases are invasive or associated with adverse effects. A minimally invasive means of sustained-release drug delivery to the vitreous is required. This study evaluated a novel device for subtenon drug delivery to the vitreous, relative to a single subconjunctival injection. METHODS: Sixty adult New Zealand White rabbits were randomly assigned to receive demethylvancomycin (DMV) by continuous subtenon delivery with the flow rate of 0...
April 9, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28391646/factors-affecting-signal-strength-in-spectral-domain-optical-coherence-tomography
#20
Ryan Lee, Yih-Chung Tham, Carol Y Cheung, Elizabeth Sidhartha, Rosalynn Grace Siantar, Sing-Hui Lim, Tien Yin Wong, Ching-Yu Cheng
PURPOSE: To identify ocular factors that affect signal strength in spectral-domain optical coherence tomography (SD-OCT). METHODS: Data from 1312 participants of the population-based Singapore Malay Eye Study-2 (SiMES-2) were included in the analysis. All participants underwent standardized ophthalmic examination, including measurements of best-corrected visual acuity (BCVA), refractive error, axial length, corneal curvature and presence of cataracts. Optic disc and macular cube scans were acquired using the Cirrus HD-OCT (software version 6...
April 9, 2017: Acta Ophthalmologica
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