journal
https://read.qxmd.com/read/38536709/peripheral-hypertrophic-subepithelial-corneal-opacification-role-of-tear-secretion-medication-and-systemic-diseases
#1
JOURNAL ARTICLE
Jana C Riedl, Aminat Misirkhanova, Joanna Wasielica-Poslednik, Alexander K Schuster, Irene Schmidtmann, Manfred E Beutel, Norbert Pfeiffer, Adrian Gericke
BACKGROUND: Peripheral hypertrophic subepithelial corneal opacification (PHSCO) is a corneal disease that may severely affect vision. The major goal of this study was to test the hypothesis that tear secretion, medication and systemic diseases are associated with PHSCO. METHODS: This is a retrospective, case-control study conducted at the Department of Ophthalmology, University Medical Center of the Johannes Gutenberg University Mainz. We analysed medical records of patients diagnosed with PHSCO...
March 27, 2024: Acta Ophthalmologica
https://read.qxmd.com/read/38533620/novel-features-of-degenerative-retinoschisis-identified-using-ultra-widefield-multicolor-channels-a-review-of-139-eyes
#2
JOURNAL ARTICLE
Samantha Orr, Amin Hatamnejad, Simrat Sodhi, John Golding, Niveditha Pattathil, Netan Choudhry
BACKGROUND/OBJECTIVE: To utilize ultra-widefield multimodal imaging (Optos PLC) to describe novel findings in degenerative retinoschisis. METHODS: This retrospective, non-comparative case series of degenerative retinoschisis received a waiver of consent from Advarra IRB, Protocol 00066379. Initial ultra-widefield pseudocolour, colour-separated, autofluorescence, and peripheral OCT imaging were analysed for characterizing features. RESULTS: In total, 139 eyes were included...
March 27, 2024: Acta Ophthalmologica
https://read.qxmd.com/read/38528623/age-related-macular-degeneration-discordance-in-monozygotic-twin-pairs
#3
JOURNAL ARTICLE
Fabian Kananen, Jaakko Kaprio, Ilkka Immonen
PURPOSE: To examine age-related macular degeneration (AMD) and retinal pigment epithelium (RPE)-Bruch's membrane (BrM) complex volume associations in monozygotic twin pairs. METHODS: In this study, 106 elderly twins (53 twin pairs) from the Finnish Twin Cohort study were recruited. Each participant underwent dilated 35-degree digital colour fundus photography (CFP), and spectral domain optical coherence tomography (OCT) and replied to a structured study questionnaire...
March 25, 2024: Acta Ophthalmologica
https://read.qxmd.com/read/38525896/real-world-experiences-with-intravitreal-treatment-with-ranibizumab-and-aflibercept-for-diabetic-macular-oedema-2008-2021
#4
LETTER
Johanne Bjerre Lindboe, Troels Brynskov, Torben Lykke Sørensen, Caroline Schmidt Laugesen
No abstract text is available yet for this article.
March 25, 2024: Acta Ophthalmologica
https://read.qxmd.com/read/38525840/age-related-nonparalytic-hypertropia-clinical-features
#5
JOURNAL ARTICLE
Akihiko Oohira
PURPOSE: Age-related nonparalytic hypertropia (ARNH) is reported to be involved in sagging eye syndrome, where excyclotorsion is large and the lower eye is more extorted. The primary aim of this study was to describe the clinical profiles of patients with ARNH. The secondary aim was to compare cyclotorsion in patients with ARNH with that in normal individuals. METHODS: Inclusion criteria for ARNH were insidious onset of diplopia at distance after 50 years of age, nonparalytic hyperdeviation and follow-up >6 months...
March 25, 2024: Acta Ophthalmologica
https://read.qxmd.com/read/38523129/the-incidence-and-prevalence-of-diabetic-macular-edema-and-proliferative-diabetic-retinopathy-their-progression-to-visual-impairment-and-patterns-in-their-intravitreal-treatment-in-the-finnish-population
#6
JOURNAL ARTICLE
Hanna Heloterä, Martti Arffman, Reijo Sund, Ilmo Keskimäki, Kai Kaarniranta
PURPOSE: The worldwide prevalence of diabetes mellitus (DM) continues to increase. As DM is linked to various ophthalmological comorbidities, it is crucial to understand the incidence and the treatment patterns of these complications to minimise the treatment burden for the patient and the healthcare system. This study aims to evaluate the incidence and prevalence of diabetic macular oedema (DME) and proliferative diabetic retinopathy (PDR) and to analyse intravitreal (IVT) treatment patterns and responses in the Finnish population with diabetes...
March 24, 2024: Acta Ophthalmologica
https://read.qxmd.com/read/38516719/machine-learning-based-nomogram-to-predict-poor-response-to-overnight-orthokeratology-in-chinese-myopic-children-a-multicentre-retrospective-study
#7
JOURNAL ARTICLE
Wenting Tang, Jiaqian Li, Xuelin Fu, Quan Lin, Li Zhang, Xiangning Luo, Wenjing Zhao, Jia Liao, Xinyue Xu, Xiaoqin Wang, Huidan Zhang, Jing Li
PURPOSE: To develop and validate an effective nomogram for predicting poor response to orthokeratology. METHODS: Myopic children (aged 8-15 years) treated with orthokeratology between February 2018 and January 2022 were screened in four hospitals of different tiers (i.e. municipal and provincial) in China. Potential predictors included 32 baseline clinical variables. Nomogram for the outcome (1-year axial elongation ≥0.20 mm: poor response; <0...
March 22, 2024: Acta Ophthalmologica
https://read.qxmd.com/read/38506096/surrogate-optimisation-strategies-for-intraocular-lens-formula-constant-optimisation
#8
JOURNAL ARTICLE
Achim Langenbucher, Jascha Wendelstein, Alan Cayless, Peter Hoffmann, Nóra Szentmáry
PURPOSE: To investigate surrogate optimisation (SO) as a modern, purely data-driven, nonlinear adaptive iterative strategy for lens formula constant optimisation in intraocular lens power calculation. METHODS: A SO algorithm was implemented for optimising the root mean squared formula prediction error (rmsPE, defined as predicted refraction minus achieved refraction) for the SRKT, Hoffer Q, Holladay, Haigis and Castrop formulae in a dataset of N = 888 cataractous eyes with implantation of the Hoya Vivinex hydrophobic acrylic aspheric lens...
March 20, 2024: Acta Ophthalmologica
https://read.qxmd.com/read/38501705/paediatric-optic-pit-associated-macular-detachment-a-treatment-strategy
#9
LETTER
Sonja Kiehelä, Sirpa Loukovaara
No abstract text is available yet for this article.
March 19, 2024: Acta Ophthalmologica
https://read.qxmd.com/read/38477813/mid-term-surgical-success-after-transscleral-ab-interno-glaucoma-gel-stent-implantation
#10
JOURNAL ARTICLE
Markus Lenzhofer, Melchior Hohensinn, Veit Steiner, Wolfgang Hitzl, Christian Runge, Andrea Trost, Hans Peter Colvin, Susanne Brunner, Julia Preishuber-Pflügl, Herbert A Reitsamer
PURPOSE: To investigate the surgical success and efficacy of XEN45 implantation (XEN45 μm, AbbVie Inc., USA) with and without combined cataract surgery up to the first 5 years. METHODS: In a prospective observational monocentric trial, 192 eyes of 157 patients with open-angle glaucoma received either XEN45 implants only (solo surgery group) or combined surgery/cataract surgeries (combined surgery group). Surgical success (qualified and full success; IOP-limit: ≤12, 15, 18, 21 mmHg), time to secondary IOP-lowering procedure, IOP and number of IOP-lowering medications were analysed for 1, 2, 3, 4 and 5 years...
March 13, 2024: Acta Ophthalmologica
https://read.qxmd.com/read/38470990/pretreatment-ocular-blood-flow-and-retinal-oxygen-metabolism-in%C3%A2-the-acute-uveitic-phase-is-associated-with-final-outcome-in-vogt-koyanagi-harada-disease
#11
JOURNAL ARTICLE
Ahmed M Abu El-Asrar, Abdulrahman F AlBloushi, Abdullah Alzubaidi, Priscilla W Gikandi, Einar Stefánsson
PURPOSE: To investigate the association between pretreatment blood flow velocity in the choroid and optic nerve head (ONH) and retinal oxygen metabolism in the acute uveitic phase and the development of 'sunset glow fundus' in Vogt-Koyanagi-Harada (VKH) disease. METHODS: Retrospective analysis of 41 patients (82 eyes). Laser speckle flowgraphy and retinal oximetry measurements were performed at the presentation. The main outcome measure was the development of 'sunset glow fundus'...
March 12, 2024: Acta Ophthalmologica
https://read.qxmd.com/read/38450902/macular-morphology-is-not-affected-by-low-or-high-birthweight-in-individuals-born-at-term-results-from-the-gutenberg-prematurity-eye-study
#12
LETTER
Achim Fieß, Sandra Gißler, Eva Mildenberger, Michael S Urschitz, Panagotios Laspas, Bernhard Stoffelns, Norbert Pfeiffer, Alica Hartmann, Alexander K Schuster
No abstract text is available yet for this article.
March 7, 2024: Acta Ophthalmologica
https://read.qxmd.com/read/38440865/long-term-impact-of-low-energy-femtosecond-laser-and-manual-cataract-surgery-on-macular-layer-thickness-a-prospective-randomized-study
#13
JOURNAL ARTICLE
Luca Schwarzenbacher, Ursula Schmidt-Erfurth, Daniel Schartmüller, Veronika Röggla, Christina Leydolt, Rupert Menapace, Gregor S Reiter
PURPOSE: To evaluate change in retinal layers 18 months after femtosecond laser-assisted cataract surgery (LCS) and manual cataract surgery (MCS) in a representative age-related cataract population using artificial intelligence (AI)-based automated retinal layer segmentation. METHODS: This was a prospective, randomized and intraindividual-controlled study including 60 patients at the Medical University of Vienna, Austria. Bilateral same-day LCS and MCS were performed in a randomized sequence...
March 5, 2024: Acta Ophthalmologica
https://read.qxmd.com/read/38420891/high-risk-histopathologic-features-in-local-advanced-conjunctival-melanoma
#14
JOURNAL ARTICLE
Tianyu Zhu, Chunyan Zong, Yongyun Li, Shichong Jia, Hanhan Shi, Hao Tian, Yamin Rao, Xiao Zhang, Shengfang Ge, Xianqun Fan, Yimin Li, Renbing Jia, Shiqiong Xu
PURPOSE: To identify high-risk histopathologic and molecular features of local recurrence, nodal metastasis, distant metastasis (DM) and disease-specific death (DSD) in conjunctival melanoma (CoM). METHODS: Ninety patients with pathologically diagnosed CoM between 2008 and 2023 were enrolled. Immunohistochemistry staining of BRAFV600E , NRASQ61R , CD117, PD-1 and PD-L1 was performed in 65 and 45 patients, respectively. Cox regression and Kaplan-Meier survival analysis were conducted to identify risk factors for local recurrence, nodal metastasis, DM and DSD...
February 29, 2024: Acta Ophthalmologica
https://read.qxmd.com/read/38415914/mitochondrial-damage-and-clearance-in-retinal-pigment-epithelial-cells
#15
JOURNAL ARTICLE
Iswariyaraja Sridevi Gurubaran
No abstract text is available yet for this article.
February 28, 2024: Acta Ophthalmologica
https://read.qxmd.com/read/38396344/systemic-risk-factors-of-retinopathy-in-patients-with-systemic-lupus-erythematosus
#16
JOURNAL ARTICLE
Lihui Meng, Qianyi Yu, Xinyu Zhao, Lulu Chen, Jingyuan Yang, Yuelin Wang, Huan Chen, Youxin Chen
OBJECTIVE: To investigate the risk factors of lupus retinopathy (LR) in patients with systemic lupus erythematosus (SLE). METHODS: This is a retrospective, cross-sectional study. LR patients admitted at Peking Union Medical College Hospital from June 2013 to April 2023 were reviewed. Age- and gender-matched SLE patients without retinopathy were selected as controls. Medical records including clinical manifestations, laboratory data and ophthalmic examination were collected...
February 23, 2024: Acta Ophthalmologica
https://read.qxmd.com/read/38376121/comparing-the-safety-and-efficacy-of-preserflo-microshunt-implantation-and-trabeculectomy-for-glaucoma-a-systematic-review-and-meta-analysis
#17
REVIEW
Adan Khan, Attam Ullah Khan
To compare the safety and efficacy of the Preserflo Microshunt with trabeculectomy in the treatment of patients with glaucoma. A systematic review and meta-analysis was conducted. The primary outcome measures recorded as a measure of efficacy of the interventions were intra-ocular pressure (IOP) at final follow-up and IOP reduction (IOPR). Secondary outcomes recorded to measure efficacy were reduction in the number of glaucoma medications and reinterventions. To assess safety profile, the proportions of patients with post-operative complications were recorded...
February 20, 2024: Acta Ophthalmologica
https://read.qxmd.com/read/38348755/phenotypic-characteristics-of-danish-patients-with-achromatopsia
#18
JOURNAL ARTICLE
Mette K G Andersen, Mette Bertelsen, Svend Gundestrup, Karen Grønskov, Line Kessel
PURPOSE: To describe the phenotype of Danish patients with genetically verified achromatopsia (ACHM) with special focus on signs of progression on structural or functional parameters, and possible genotype-phenotype correlations. METHODS: Forty-eight patients were identified, with disease-causing variants in five different genes: CNGA3, CNGB3, GNAT2, PDE6C and PDE6H. Longitudinal evaluation was possible for 11 patients and 27 patients participated in a renewed in-depth phenotyping consisting of visual acuity assessment, optical coherence tomography (OCT), fundus autofluorescence, colour vision evaluation, contrast sensitivity, mesopic microperimetry and full-field electroretinography...
February 13, 2024: Acta Ophthalmologica
https://read.qxmd.com/read/38345204/diabetic-retinopathy-as-an-independent-marker-of-cardiovascular-disease-in-type-1-diabetes-results-from-a-nationwide-longitudinal-matched-case-cohort-study
#19
JOURNAL ARTICLE
Ditte Simmelkaer Mabala, Lonny Stokholm, Nis Andersen, Jens Andresen, Toke Bek, Steffen Heegaard, Javad Hajari, Kurt Højlund, Ryo Kawasaki, Caroline Schmidt Laugesen, Sören Möller, Frederik Nørregaard Pedersen, Katja Christina Schielke, Anne Suhr Thykjaer, Jakob Grauslund
PURPOSE: To investigate diabetic retinopathy (DR) as a potential marker of cardiovascular disease (CVD) in adults with type 1 diabetes attending the Danish DR-screening programme and non-diabetes adults. METHODS: In this registry-based matched case-cohort study, we identified 16 547 adults with type 1 diabetes, who were registered in the Danish Registry of Diabetic Retinopathy (DiaBase). Each case was age- and sex-matched by five non-diabetes individuals (n = 82 399), and odds ratios (ORs) and hazard ratios (HRs) were estimated for incident and upcoming CVD in multivariable models...
February 12, 2024: Acta Ophthalmologica
https://read.qxmd.com/read/38345159/deepalienornet-a-deep-learning-model-to-extract-clinical-features-from-colour-fundus-photography-in-age-related-macular-degeneration
#20
JOURNAL ARTICLE
Alexis Mathieu, Soufiane Ajana, Jean-François Korobelnik, Mélanie Le Goff, Brigitte Gontier, Marie-Bénédicte Rougier, Cécile Delcourt, Marie-Noëlle Delyfer
OBJECTIVE: This study aimed to develop a deep learning (DL) model, named 'DeepAlienorNet', to automatically extract clinical signs of age-related macular degeneration (AMD) from colour fundus photography (CFP). METHODS AND ANALYSIS: The ALIENOR Study is a cohort of French individuals 77 years of age or older. A multi-label DL model was developed to grade the presence of 7 clinical signs: large soft drusen (>125 μm), intermediate soft (63-125 μm), large area of soft drusen (total area >500 μm), presence of central soft drusen (large or intermediate), hyperpigmentation, hypopigmentation, and advanced AMD (defined as neovascular or atrophic AMD)...
February 12, 2024: Acta Ophthalmologica
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