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Acta Ophthalmologica

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https://www.readbyqxmd.com/read/29144028/efficacy-and-safety-of-different-regimens-for-primary-open-angle-glaucoma-or-ocular-hypertension-a-systematic-review-and-network-meta-analysis
#1
Fei Li, Wenbin Huang, Xiulan Zhang
PURPOSE: To assess the efficacy and safety of different regimens, including monotherapy and double therapy, for primary open-angle glaucoma (POAG) or ocular hypertension. METHODS: We searched PubMed, EMBASE and clinicaltrials.gov for studies that fit our inclusion criteria in this network meta-analysis. Randomized controlled trials that report data on efficacy and safety of medications for POAG or ocular hypertension are included. Data on intra-ocular pressure (IOP) lowering effect and incidence of adverse events including hyperaemia and ocular discomfort were extracted and used in mixed-comparison analysis...
November 16, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29131557/comparison-of-self-made-cryopreservative-fibrin-glue-and-commercial-fibrin-glue-kit-in-pterygium-surgery-1-year-follow-up
#2
Jingwen Gong, Jiaqi Fan, Ting Shen, Jin Jiang
PURPOSE: To assess long-term efficacy and safety of self-made cryopreservative fibrin glue (SMC) applied in pterygium surgery. METHODS: Prospective, comparative, interventional case series. Forty eyes of 40 patients with nasal primary pterygium, 24 male and 16 female, were enrolled. The patients were assigned to two groups and each contained 12 male and eight female based on the pterygium area encroaching onto the cornea. In one group, the conjunctival autograft was attached to the sclera with SMC stored for 2 months, and in the other group, commercial fibrin glue kit (CK) was applied after the pterygium was removed...
November 13, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29131515/enhanced-resolution-and-speckle-free-three-dimensional-printing-of-macular-optical-coherence-tomography-angiography
#3
Peter M Maloca, Richard F Spaide, Simon Rothenbuehler, Hendrik P N Scholl, Tjebo Heeren, João E Ramos de Carvalho, Mali Okada, Pascal W Hasler, Catherine Egan, Adnan Tufail
No abstract text is available yet for this article.
November 13, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29130647/randomized-controlled-trial-of-electro-stimulation-therapies-to-modulate-retinal-blood-flow-and-visual-function-in-retinitis-pigmentosa
#4
Ava K Bittner, Kenneth Seger, Rachel Salveson, Samantha Kayser, Natalia Morrison, Patricia Vargas, Deborah Mendelsohn, Jorge Han, Hua Bi, Gislin Dagnelie, Alexandra Benavente, Jessica Ramella-Roman
PURPOSE: We examined changes in visual function and ocular and retinal blood flow (RBF) among retinitis pigmentosa (RP) participants in a randomized controlled trial of electro-stimulation therapies. METHODS: Twenty-one RP participants were randomized (1:1:1) to transcorneal electrical stimulation (TES) at 6 weekly half-hour sessions, electro-acupuncture or inactive laser acupuncture (sham control) at 10 half-hour sessions over 2 weeks. Early Treatment of Diabetic Retinopathy Study (ETDRS) visual acuity (VA), quick contrast sensitivity function, Goldmann visual fields, AdaptDx scotopic sensitivity, spectral flow and colour Doppler imaging of the central retinal artery (CRA), and RBF in macular capillaries were measured twice pre-treatment, after 2 TES sessions, within a week and a month after intervention completion...
November 11, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29130626/age-related-macular-degeneration-using-morphological-predictors-to-modify-current-treatment-protocols
#5
REVIEW
Mohammed Ashraf, Ahmed Souka, Ron A Adelman
To assess predictors of treatment response in neovascular age-related macular degeneration (AMD) in an attempt to develop a patient-centric treatment algorithm. We conducted a systematic search using PubMed, EMBASE and Web of Science for prognostic indicators/predictive factors with the key words: 'age related macular degeneration', 'neovascular AMD', 'choroidal neovascular membrane (CNV)', 'anti-vascular endothelial growth factor (anti-VEGF)', 'aflibercept', 'ranibizumab', 'bevacizumab', 'randomized clinical trials', 'post-hoc', 'prognostic', 'predictive', 'response' 'injection frequency, 'treat and extend (TAE), 'pro re nata (PRN)', 'bi-monthly' and 'quarterly'...
November 11, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29115726/efficacy-of-predetermined-therapeutic-measures-against-bleb-related-infection-in-the-collaborative-bleb-related-infection-incidence-and-treatment-study
#6
Nobuyuki Shoji, Yoshikuni Arakaki, Kenji Nakamoto, Tetsuya Yamamoto, Yasuaki Kuwayama
PURPOSE: To report the efficacy of the predetermined treatment protocol of the Collaborative Bleb-related Infection Incidence and Treatment Study (CBIITS) for bleb-related infection (BRI) patients. METHODS: A prospective, observational cohort study was conducted at 34 clinical centres in Japan. Nineteen eyes from 19 patients that developed BRI were treated using the CBIITS protocol at 34 clinical centres. The visual acuity (VA) and intraocular pressure (IOP) were monitored for 6 and 12 months after treatment with the predetermined protocol...
November 8, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29105362/monitoring-foveal-sparing-in-geographic-atrophy-with-fluorescence-lifetime-imaging-ophthalmoscopy-a-novel-approach
#7
Lydia Sauer, Matthias Klemm, Sven Peters, Dietrich Schweitzer, Johanna Schmidt, Lukas Kreilkamp, Lisa Ramm, Daniel Meller, Martin Hammer
PURPOSE: To investigate fundus autofluorescence (FAF) lifetimes in geographic atrophy (GA) with a focus on macular pigment (MP) and foveal sparing. METHODS: The study included 35 eyes from 28 patients (mean age 79.2 ± 8.0 years) with GA. A 30° retinal field, centred at the macula, was investigated using fluorescence lifetime imaging ophthalmoscopy (FLIO). The FLIO technology is based on a Heidelberg Engineering Spectralis system. Decays of FAF were detected in a short (498-560 nm, SSC) and long (560-720 nm, LSC) spectral channel...
November 4, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29105334/genetic-prognostication-in-uveal-melanoma
#8
REVIEW
Mehmet Dogrusöz, Martine J Jager
Uveal melanoma (UM) is a rare tumour with a high propensity to metastasize. Although no effective treatment for metastases yet exists, prognostication in UM is relevant for patient counselling, planning of follow-up and stratification in clinical trials. Besides conventional clinicopathologic characteristics, genetic tumour features with prognostic significance have been identified. Non-random chromosome aberrations such as monosomy 3 and gain of chromosome 8q are strongly correlated with metastatic risk, while gain of chromosome 6p indicates a low risk...
November 4, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29098810/regulation-of-oxygen-saturation-in-retinal-blood-vessels-in-response-to-dynamic-exercise
#9
Rebekka Heitmar, Pravin Vekria, Robert P Cubbidge
PURPOSE: To evaluate the impact of dynamic exercise on retinal vessel oxygen saturation in healthy individuals. METHODS: Twenty-six healthy participants underwent moderate dynamic exercise (modified Master's two-step exercise). In all subjects, intraocular pressures (IOP), systolic and diastolic blood pressures (SBP and DBP), retinal vessel calibres and retinal arterial and venous oxygen saturation were measured at baseline, immediately following exercise and 15 min postexercise...
November 2, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29098804/fundus-autofluorescence-imaging-in-hereditary-retinal-diseases
#10
REVIEW
Francesco Pichi, Emad B Abboud, Nicola G Ghazi, Arif O Khan
Fundus autofluorescence (FAF) is a non-invasive retinal imaging modality used in clinical practice to non-invasively map changes at the level of the retinal pigment epithelium (RPE)/photoreceptor complex and alterations of macular pigment distribution. This imaging method is based on the visualization of intrinsic fluorophores and may be easily and rapidly used in routine patient care. Excessive accumulation of lipofuscin granules in the lysosomal compartment of RPE cells represents a common downstream pathogenic pathway in various hereditary and complex retinal diseases...
November 2, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29098802/more-breakdown-of-blood-ocular-barriers-after-vitrectomy-than-scleral-buckling
#11
LETTER
Verena C Mulder, Ellen C La Heij, Jan C van Meurs
No abstract text is available yet for this article.
November 2, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29098796/ganglion-cell-inner-plexiform-layer-and-retinal-nerve-fibre-layer-changes-within-the-macula-in-retinitis-pigmentosa-a-spectral-domain-optical-coherence-tomography-study
#12
Chang Ki Yoon, Hyeong Gon Yu
PURPOSE: To investigate how macular ganglion cell-inner plexiform layer (GCIPL) and retinal nerve fibre layer (RNFL) thicknesses within the macula change with retinitis pigmentosa (RP) severity. METHODS: Spectral domain optical coherence tomography (SD-OCT) was used to examine 177 patients with RP and 177 normal controls. An optical coherence tomography (OCT) line scan was used to grade RP severity. Retinitis pigmentosa (RP) was categorized as more advanced if there was no identifiable inner segment ellipsoid (ISe) band (NISE) and as less advanced if an ISe band could be identified and peripheral loss of ISe was apparent (IISE)...
November 2, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29098795/is-lack-of-autonomic-nerves-in-retinal-vessels-a-protection-from-electrical-stimulation-generated-by-activity-in-visual-neurons
#13
LETTER
Toke Bek
No abstract text is available yet for this article.
November 2, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29098793/association-of-150-kda-oxygen-regulated-protein-with-vascular-endothelial-growth-factor-in-proliferative-diabetic-retinopathy
#14
Ahmed M Abu El-Asrar, Ajmal Ahmad, Kaiser Alam, Emilie Bittoun, Mohammad Mairaj Siddiquei, Ghulam Mohammad, Ahmed Mousa, Gert De Hertogh, Ghislain Opdenakker
PURPOSE: 150-kDa oxygen-regulated protein (ORP150), a member of heat-shock protein family located in endoplasmic reticulum (ER), has a critical role in secretion of vascular endothelial growth factor (VEGF). We investigated expression levels of ORP150 and correlated these levels with VEGF and total vitreous antioxidant capacity (TAC) in proliferative diabetic retinopathy (PDR). We also examined expression of ORP150 in retinas of diabetic rats and in human retinal microvascular endothelial cells (HRMEC)...
November 2, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29098792/causes-of-intracapsular-cataract-extraction-explantation-of-intraocular-lenses-and-suture-scleral-fixation-of-intraocular-lenses-in-the-modern-era
#15
LETTER
Kazunobu Sugihara, Masaki Tanito, Yasuyuki Takai, Akihiro Ohira
No abstract text is available yet for this article.
November 2, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29098790/agreement-of-phakic-and-pseudophakic-anterior-chamber-depth-measurements-in-iolmaster-and-pentacam
#16
LETTER
Hassan Hamoudi, Ulrik Correll Christensen, Morten la Cour
No abstract text is available yet for this article.
November 2, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29091347/thickness-mapping-of-individual-retinal-layers-and-sectors-by-spectralis-sd-oct-in-autosomal-dominant-optic-atrophy
#17
Nihada Corajevic, Michael Larsen, Cecilia Rönnbäck
PURPOSE: To assess layer- and location-specific retinal thickness deficits in autosomal dominant optic atrophy (ADOA) using Spectralis SD-OCT. METHODS: This cross-sectional study included 41 ADOA patients with OPA1 exon 28 (2826delT) mutation [age, 8.6-83.5 years; best-corrected visual acuity (BCVA), 8-89 Early Treatment Diabetic Retinopathy Study (ETDRS) letters] and 55 mutation-free first-degree relatives as healthy controls (age, 8.9-68.7; BCVA, 80-99). Participants underwent routine examination and optical coherence tomography (OCT) with segmentation of the whole retina, inner retinal layers (IRL) and outer retinal layers (ORL)...
November 1, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29090852/macular-thinning-in-prediabetes-or-type-2-diabetes-without-diabetic-retinopathy-the-maastricht-study
#18
Eline E B De Clerck, Jan S A G Schouten, Tos T J M Berendschot, Fleur Goezinne, Pieter C Dagnelie, Nicolaas C Schaper, Miranda T Schram, Coen D A Stehouwer, Carroll A B Webers
PURPOSE: To assess macular thinning in individuals with prediabetes or type 2 diabetes without diabetic retinopathy (DM2 w/o DR) compared with individuals with normal glucose metabolism (NGM). METHODS: Using spectral domain optical coherence tomography (SD-OCT), we measured macular thickness in six subfields as defined by the Early Treatment Diabetic Retinopathy Study (ETDRS) in 1838 participants from The Maastricht Study, a population-based cohort study (mean age 59 ± 8 years, 49% men, 1087 NGM, 279 prediabetes, 472 DM2 w/o DR)...
November 1, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29090846/the-relation-study-efficacy-and-safety-of-ranibizumab-combined-with-laser-photocoagulation-treatment-versus-laser-monotherapy-in-npdr-and-pdr-patients-with-diabetic-macular-oedema
#19
Gabriele E Lang, Sandra Liakopoulos, Jessica Vögeler, Claudia Weiß, Georg Spital, Maria-Andreea Gamulescu, Chris Lohmann, Peter Wiedemann
PURPOSE: To assess efficacy and safety of intravitreal ranibizumab 0.5 mg plus laser (COMBI) versus laser monotherapy (LASER) in patients with visual impairment due to diabetic macular oedema (DME) in either nonproliferative diabetic retinopathy (NPDR) or proliferative diabetic retinopathy (PDR) and to analyse the relevance of inner versus outer retinal thickness. METHODS: In this double-masked, multicentre phase IIIb study, patients (N = 128) were randomized (2:1) to receive COMBI (n = 85) versus LASER (n = 43)...
November 1, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29090844/computer-aided-diagnosis-based-on-enhancement-of-degraded-fundus-photographs
#20
Kai Jin, Mei Zhou, Shaoze Wang, Lixia Lou, Yufeng Xu, Juan Ye, Dahong Qian
PURPOSE: Retinal imaging is an important and effective tool for detecting retinal diseases. However, degraded images caused by the aberrations of the eye can disguise lesions, so that a diseased eye can be mistakenly diagnosed as normal. In this work, we propose a new image enhancement method to improve the quality of degraded images. METHODS: A new method is used to enhance degraded-quality fundus images. In this method, the image is converted from the input RGB colour space to LAB colour space and then each normalized component is enhanced using contrast-limited adaptive histogram equalization...
November 1, 2017: Acta Ophthalmologica
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