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Acta Ophthalmologica

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https://www.readbyqxmd.com/read/29350795/phacoemulsification-and-primary-implantation-with-bag-in-the-lens-intraocular-lens-in-children-with-unilateral-and-bilateral-cataract
#1
Alf Nyström, Nawaf Almarzouki, Gunilla Magnusson, Madeleine Zetterberg
PURPOSE: To report outcome in a paediatric cohort with cataract extraction and implantation of bag-in-the-lens intraocular lens (BIL-IOL). METHODS: Children younger than 16 years of age subjected to phacoemulsification with primary implantation of BIL-IOL during 2009 through 2013 were analysed retrospectively. Exclusion criteria were uveitis or ≤6 months of follow-up. RESULTS: In total, 109 eyes of 84 children were included; 40 unilateral and 44 bilateral cataracts...
January 19, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29350790/outcomes-and-complications-of-baerveldt-glaucoma-drainage-implants-for-the-treatment-of-uveitis-related-glaucoma
#2
LETTER
Roselie M Diederen, Caroline A Hulsman, Richard Hc Zegers, Frank D Verbraak
No abstract text is available yet for this article.
January 19, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29338134/retinal-oximetry-is-affected-in-multiple-sclerosis
#3
Anna Bryndis Einarsdottir, Olof Birna Olafsdottir, Haukur Hjaltason, Sveinn Hakon Hardarson
PURPOSE: Structural and physiological abnormalities have been reported in the retina in patients with multiple sclerosis (MS). Retinal oximetry has recently detected changes in retinal oxygen metabolism in Alzheimer's disease and mild cognitive impairment. Our goal was to determine whether oxygen saturation in retinal blood vessels of patients with patients is different from that of a healthy population. METHODS: Oxygen saturation of haemoglobin was measured in retinal blood vessels, using imaging with spectrophotometric noninvasive retinal oximeter...
January 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29338133/pimasertib-associated-ophthalmological-adverse-events
#4
Elon H C van Dijk, Wim H J Kruit, Martine J Jager, Gregorius P M Luyten, Johannes R Vingerling, Camiel J F Boon
PURPOSE: To analyse ophthalmological adverse events associated with mitogen-activated protein kinase kinase (MEK) inhibition with pimasertib treatment for metastatic cutaneous melanoma (CM). METHODS: In this prospective observational, cohort-based, cross-sectional study, eight patients treated with the MEK inhibitor pimasertib received a complete ophthalmic examination. This included Early Treatment of Diabetic Retinopathy Study best-corrected visual acuity, visual field testing, colour vision testing, slit-lamp examination, applanation tonometry, indirect ophthalmoscopy, digital colour fundus photography and optical coherence tomography (OCT)...
January 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29338132/tumour-thickness-diameter-area-or-volume-the-prognostic-significance-of-conventional-versus-digital-image-analysis-based-size-estimation-methods-in-uveal-melanoma
#5
Thorsteinn Snaebjörnsson Arnljots, Zaid Al-Sharbaty, Emma Lardner, Charlotta All-Eriksson, Stefan Seregard, Gustav Stålhammar
PURPOSE: The aim of this study was to compare conventional and novel size estimation methods' ability to predict survival in uveal melanoma (UM). METHODS: The study was designed as a retrospective consecutive chart review of patients with UM, enucleated between the years 1984 and 1993. Area and volume were estimated based on the largest histopathological cross-section, the second centroid theorem of Pappus and digital image analysis, correlated to overall and relative survival...
January 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29338130/correlation-between-morphological-characteristics-in-spectral-domain-optical-coherence-tomography-different-functional-tests-and-a-patient-s-subjective-handicap-in-acute-central-serous-chorioretinopathy
#6
Bianca S Gerendas, Julia-Sophie Kroisamer, Wolf Buehl, Sandra M Rezar-Dreindl, Katharina M Eibenberger, Eleonore Pablik, Ursula Schmidt-Erfurth, Stefan Sacu
PURPOSE: The purpose of this study was to identify quantitatively measurable morphologic optical coherence tomography (OCT) characteristics in patients with an acute episode of central serous chorioretinopathy (CSC) and evaluate their correlation to functional and psychological variables for their use in daily clinical practice. METHODS: Retinal thickness (RT), the height, area and volume of subretinal fluid (SRF)/pigment epithelium detachments were evaluated using the standardized procedures of the Vienna Reading Center...
January 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29338129/three-dimensional-visualization-and-volume-quantification-of-pigment-epithelium-detachments
#7
Yousif Subhi, Torben Lykke Sørensen
No abstract text is available yet for this article.
January 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29338126/physical-exercise-and-glaucoma-a-review-on-the-roles-of-physical-exercise-on-intraocular-pressure-control-ocular-blood-flow-regulation-neuroprotection-and-glaucoma-related-mental-health
#8
REVIEW
Ming Ming Zhu, Jimmy Shiu Ming Lai, Bonnie Nga Kwan Choy, Jennifer Wei Huen Shum, Amy Cheuk Yin Lo, Alex Lap Ki Ng, Jonathan Cheuk Hung Chan, Kwok Fai So
The benefits of physical exercise on health and well-being have been studied in a wide range of systemic and ocular diseases, including glaucoma, a progressive optic neuropathy characterized by accelerated apoptosis of retinal ganglion cells (RGCs). Elevated intraocular pressure (IOP) and insufficient ocular perfusion have been postulated to be the two main theories in glaucoma development and progression. The effects of exercise in these two aspects have been demonstrated by numerous researches. A review in 2009 focusing on these two theories concluded that exercise results in transient IOP reduction but an inconsistent elevation in ocular perfusion...
January 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29338124/conservative-therapy-for-chalazia-is-it-really-effective
#9
Albert Y Wu, Kalla A Gervasio, Kellie N Gergoudis, Chen Wei, James H Oestreicher, John T Harvey
PURPOSE: To assess the within-treatment efficacy of hot compresses (HC), HC plus tobramycin (Tobrex) and HC plus tobramycin/dexamethasone (Tobradex) for chalazia treatment. METHODS: Design: Multicentre, randomized clinical trial (ClinicalTrials.gov identifier, NCT01230593). SETTING: Two clinical sites in New York and two clinical sites in Ontario. STUDY POPULATION: A total of 149 patients with one or more chalazia on separate eyelids randomly assigned to receive HC (n = 50), HC plus tobramycin (n = 50) or HC plus tobramycin/dexamethasone (n = 49)...
January 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29338123/choroidal-thickness-and-myopia-in-relation-to-physical-activity-the-champs-eye-study
#10
Kristian Lundberg, Anders Højslet Vestergaard, Nina Jacobsen, Anne Suhr Thykjaer, Rasmus Søgaard Hansen, Ernst Goldschmidt, Tunde Peto, Ulrich Halekoh, Niels Wedderkopp, Jakob Grauslund
PURPOSE: To describe the relationship between choroidal thickness (CT) and myopia in relation to physical activity (PA) in a population-based child cohort. METHODS: In a prospective study of 307 children from the CHAMPS Study Denmark, we used objective data from GT3X accelerometer worn at four periods between 2009 and 2015 to determine the amount and intensity of PA. Intensity was estimated as counts/minutes, and cut-off points were defined at four intensity levels...
January 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29338117/nestin-expression-in-primary-and-metastatic-uveal-melanoma-possible-biomarker-for-high-risk-uveal-melanoma
#11
Luna Djirackor, Dilem Shakir, Helen Kalirai, Goran Petrovski, Sarah E Coupland
PURPOSE: Nestin, a member of the intermediate filament protein family, has been described as a putative cancer stem cell marker (CSC) in uveal melanoma and poor prognostic factor in a variety of tumours, including cutaneous melanoma. In this study, we examined the expression of nestin in primary (PUM) and metastatic uveal melanoma (MUM) samples, and correlated the findings with histological, clinical and survival data. METHODS: Nestin expression was assessed by immunohistochemistry in 141 PUM and 26 MUM samples; 11 PUM cases were matched with their corresponding metastases...
January 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29338115/statin-use-and-vitreoretinal-surgery-findings-from-a-finnish-population-based-cohort-study
#12
Sirpa Loukovaara, Sari Sahanne, Annika Takala, Jari Haukka
PURPOSE: Vitreoretinal (VR) surgery is the third most common intraocular surgery after refractive and cataract surgery. The impact of statin therapy on VR surgery outcomes remains unclear, despite a potentially beneficial effect. We explored the association of preoperative statin therapy and the need for revitrectomy after primary vitrectomy. METHODS: Our historical, population-based, register-based, VR surgery cohort consisted of 5709 patients operated in a tertiary, academic referral hospital in Finland, during 2008-2014, covering 6...
January 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29265742/axial-length-growth-and-the-risk-of-developing-myopia-in-european-children
#13
Jan Willem Lodewijk Tideman, Jan Roelof Polling, Johannes R Vingerling, Vincent W V Jaddoe, Cathy Williams, Jeremy A Guggenheim, Caroline C W Klaver
PURPOSE: To generate percentile curves of axial length (AL) for European children, which can be used to estimate the risk of myopia in adulthood. METHODS: A total of 12 386 participants from the population-based studies Generation R (Dutch children measured at both 6 and 9 years of age; N = 6934), the Avon Longitudinal Study of Parents and Children (ALSPAC) (British children 15 years of age; N = 2495) and the Rotterdam Study III (RS-III) (Dutch adults 57 years of age; N = 2957) contributed to this study...
December 19, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29251814/early-visual-outcomes-and-optical-quality-after-femtosecond-laser-small-incision-lenticule-extraction-for-myopia-and-myopic-astigmatism-correction-of-over-10-dioptres
#14
Bing Qin, Meiyan Li, Xun Chen, Walter Sekundo, Xingtao Zhou
PURPOSE: To investigate early visual and refractive outcomes, corneal stability and optical quality after femtosecond laser small-incision lenticule extraction (SMILE) for treating myopia and myopic astigmatism over -10 D. METHODS: Thirty eyes (30 patients) with myopia and myopic astigmatism of over -10 D were treated with VisuMax® femtosecond laser (version 3.0; Carl Zeiss Meditec AG, Jena, Germany). Six months postoperative safety, efficacy and predictability were evaluated...
December 18, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29240306/diabetic-macular-oedema-treated-with-intravitreal-anti-vascular-endothelial-growth-factor-2-4%C3%A2-years-follow-up-of-visual-acuity-and-retinal-thickness-in-566-patients-following-danish-national-guidelines
#15
Delila Hodzic-Hadzibegovic, Birgit Agnes Sander, Tine Juul Monberg, Michael Larsen, Henrik Lund-Andersen
PURPOSE: To investigate long-term functional and anatomical outcomes, discontinuation patterns, drug switching and rates of nonimprovement in patients treated with ranibizumab pro re nata (PRN) regimen for diabetic macular oedema (DME) according to the Danish national guidelines. METHODS: Retrospective cohort study of 566 eyes in 566 patients with centre-involved DME who started intravitreal treatment with ranibizumab between January 2011 and December 2013 in the Greater Copenhagen region...
December 14, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29240299/the-effect-of-haemopoietic-stem-cell-transplantation-on-the-ocular-phenotype-in-mucopolysaccharidosis-type-i-hurler
#16
Ahmed Javed, Tariq Aslam, Simon A Jones, Jean Mercer, Karen Tyler, Heather Church, Arunabha Ghosh, Robert Wynn, Krishanthy Sornalingam, Jane Ashworth
PURPOSE: To determine whether the ocular phenotype in patients with mucopolysaccharidosis type I (MPSI) Hurler is affected by the efficacy of previous haemopoietic stem cell transplantation (HSCT). DESIGN: A retrospective cohort study of patients with MPSI who had undergone treatment with HSCT. METHODS: Ocular phenotype was documented for each patient and compared to levels of biomarkers representing efficacy of previous transplantation. MAIN OUTCOME MEASURES: Assessment of visual acuity (VA), severity of corneal clouding and the presence of optic neuropathy or retinopathy...
December 14, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29240298/diabetic-macular-edema-innovative-technologies-and-economic-impact-new-opportunities-for-the-lombardy-region-healthcare-system
#17
Emanuela Foglia, Lucrezia Ferrario, Francesco Bandello, Camilla Ferri, Innocente Figini, Michela Franzin, Gianpiera Gambaro, Ugo Introini, Massimo Medaglia, Giovanni Staurenghi, Patrizia Tadini, Andrea Fomiatti, Davide Croce
PURPOSE: Diabetic macular edema (DME) is a leading cause of vision loss and blindness. The aim of this study was to evaluate the economic benefits of introducing additional alternative technologies (Dexamethasone intravitreal implant - DEX - and Aflibercept injections), compared with the historical scenario of Ranibizumab intravitreal injections. METHODS: A 3-year budget impact model was developed, taking into consideration the perspective of the Lombardy Region Healthcare Service (LRHS)...
December 14, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29240288/3d-printing-of-the-choroidal-vessels-and-tumours-based-on-optical-coherence-tomography
#18
Peter M Maloca, Adnan Tufail, Pascal W Hasler, Simon Rothenbuehler, Catherine Egan, J Emanuel Ramos de Carvalho, Richard F Spaide
No abstract text is available yet for this article.
December 14, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29235262/corrugated-bruch-s-membrane-in-high-myopia
#19
Jost B Jonas, Rahul A Jonas, Kyoko Ohno-Matsui, Leonard Holbach, Songhomitra Panda-Jonas
PURPOSE: To assess the appearance of Bruch's membrane (BM) in axially elongated eyes. METHODS: The light-microscopical investigation included histological anterior-posterior sections of human eyes. Using a light microscope, we assessed whether BM in the posterior segment was straight or locally corrugated. Corrugation of BM was defined as an elevation of BM with a height >20 μm over a basis of 50 μm without collateral proliferations of retinal pigment epithelium or choroidal swelling...
December 13, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29235256/automated-refraction-is-stable-1%C3%A2-week-after-uncomplicated-cataract-surgery
#20
Christoffer Ostri, Stig K Holfort, Marianne S Fich, Per Riise
PURPOSE: To compare automated refraction 1 week and 1 month after uncomplicated cataract surgery. METHODS: In this prospective cohort study, we recruited patients in a 2-month period and included consecutive patients scheduled for bilateral small-incision phacoemulsification cataract surgery. The exclusion criteria were (i) corneal and/or retinal pathology that could lead to automated refraction miscalculation and (ii) surgery complications. Automated refraction was measured 1 week and 1 month after surgery...
December 13, 2017: Acta Ophthalmologica
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