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Acta Ophthalmologica

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https://www.readbyqxmd.com/read/28342227/treatment-of-adenoviral-keratoconjunctivitis-with-a-combination-of-povidone-iodine-1-0-and-dexamethasone-0-1-drops-a-clinical-prospective-controlled-randomized-study
#1
Natalya Kovalyuk, Igor Kaiserman, Michael Mimouni, Ornit Cohen, Shmuel Levartovsky, Hilda Sherbany, Michal Mandelboim
PURPOSE: To determine the efficacy of combination povidone-iodine (PVP-I) 1.0% eyedrops and dexamethasone 0.1% eyedrops in the treatment of adenoviral keratoconjunctivitis. MATERIALS AND METHODS: In a prospective, randomized, controlled, double-blinded clinical trial patients with recent adenoviral keratoconjunctivitis (diagnosed clinically and confirmed by PCR), we randomly divided into three treatment groups: study group - received PVP-I 1.0% and dexamethasone 0...
March 25, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28321999/factors-influencing-the-contamination-rate-of-human-organ-cultured-corneas
#2
Daniel Röck, Johanna Wude, Karl U Bartz-Schmidt, Efdal Yoeruek, Sebastian Thaler, Tobias Röck
PURPOSE: To assess the influence of donor, environment and storage factors on the contamination rate of organ-cultured corneas, to consider the microbiological species causing corneal contamination and to investigate the corresponding sensitivities. METHODS: Data from 1340 consecutive donor corneas were analysed retrospectively. Logistic regression analysis was used to assess the influence of different factors on the contamination rate of organ-cultured corneas for transplantation...
March 21, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28321986/monitoring-retinoschisis-and-non-acute-retinal-detachment-by-optical-coherence-tomography-morphologic-aspects-and-clinical-impact
#3
Katharina Eibenberger, Stefan Sacu, Sandra Rezar-Dreindl, Julia Pöcksteiner, Michael Georgopoulos, Ursula Schmidt-Erfurth
PURPOSE: To differentiate retinoschisis (RS) from non-acute retinal detachment (naRD) in clinical routine using optical coherence tomography (OCT), describe unique morphological OCT characteristics and monitor disease progression. METHODS: This prospective, observational study included 64 eyes of 44 patients with either RS or naRD. Patients were examined clinically and using Heidelberg Spectralis OCT(®) , Topcon DRI OCT(®) and Cirrus HRA-OCT(®) over 2 years with follow-up at 1, 3, 6, 12 and 24 months...
March 21, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28296082/monitoring-daily-intraocular-pressure-fluctuations-with-self-tonometry-in-healthy-subjects
#4
Laurence Quérat, Enping Chen
PURPOSE: To evaluate the accuracy of the intraocular pressure (IOP) measured by healthy subjects with icare(®) Home and to observe the IOP fluctuation and pattern of IOP fluctuation in healthy subjects over three consecutive days. METHODS: Sixty healthy subjects were recruited to the study. IOP was measured by the subjects themselves and by study staff using icare(®) Home tonometers on visits 1 and 2, as well as by study staff using Goldmann applanation tonometry (GAT)...
March 14, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28271634/choroideremia-melanopsin-mediated-postillumination-pupil-relaxation-is-abnormally-slow
#5
Shakoor Ba-Ali, Søren Kirchhoff Christensen, Birgit Sander, Thomas Rosenberg, Michael Larsen, Henrik Lund-Andersen
PURPOSE: To investigate the rod-cone and melanopsin pupillary light response (PLR) pathways in choroideremia. METHODS: Eight patients with choroideremia and 18 healthy age-matched controls underwent chromatic pupillometry by applying blue (463 nm) and red light (643 nm) at 100 lux intensity to the right eye while recording pupil diameters. Absolute baseline pupil size (mm), normalized maximal pupil constriction and the early and late postillumination pupillary dilation, from 0 to 10 seconds and 10 to 30 seconds after the end of illumination, respectively, were determined...
March 8, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28271619/reduced-anterior-chamber-contamination-by-frequent-surface-irrigation-with-diluted-iodine-solutions-during-cataract-surgery
#6
Hiroyuki Shimada, Shinji Arai, Hiroyuki Nakashizuka, Takayuki Hattori, Mitsuko Yuzawa
PURPOSE: To verify that ocular surface irrigation with 0.025% povidone-iodine (PI) or 0.0025% polyvinyl alcohol-iodine (PAI) during cataract surgery minimizes bacterial contamination of the anterior chamber. METHODS: The study was a prospective, interventional case series. First, the bactericidal effect of PI or PAI against Staphylococcus aureus was evaluated in vitro. Next, in 400 eyes undergoing cataract surgery, the ocular surface was irrigated every 20 seconds during surgery with balanced salt solution (BSS; 200 eyes) or BSS containing 0...
March 8, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28271618/plasma-long-chain-omega-3-polyunsaturated-fatty-acids-and-macular-pigment-in-subjects-with-family-history-of-age-related-macular-degeneration-the-limpia-study
#7
Bénédicte M J Merle, Benjamin Buaud, Jean-François Korobelnik, Alain Bron, Marie-Noëlle Delyfer, Marie-Bénédicte Rougier, Hélène Savel, Carole Vaysse, Catherine Creuzot-Garcher, Cécile Delcourt
PURPOSE: In numerous epidemiological studies, omega-3 polyunsaturated fatty acids (PUFAs) have been associated with a decreased risk of age-related macular degeneration (AMD). Beyond their structural, functional and neuroprotective roles, omega-3 PUFAs may favour the retinal accumulation of lutein and zeaxanthin and thus increase macular pigment optical density (MPOD). We examined the associations of MPOD with plasma omega-3 PUFAs in subjects with family history of AMD. METHODS: The Limpia study is a double-blind, placebo-controlled, prospective randomized clinical trial performed in 120 subjects...
March 8, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28271612/association-between-pseudodrusen-and-delayed-patchy-choroidal-filling-in%C3%A2-the-comparison-of-age-related-macular-degeneration-treatments-trials
#8
LETTER
Qiang Zhou, Ebenezer Daniel, Juan E Grunwald, Maureen G Maguire, Dina Y Gewaily, Daniel F Martin, Gui-Shuang Ying
No abstract text is available yet for this article.
March 8, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28271611/nlrp3-inflammasome-activation-is-associated-with-proliferative-diabetic-retinopathy
#9
Sirpa Loukovaara, Niina Piippo, Kati Kinnunen, Maria Hytti, Kai Kaarniranta, Anu Kauppinen
PURPOSE: Innate immunity and dysregulation of inflammatory processes play a role in vascular diseases like atherosclerosis or diabetes. Nucleotide-binding domain and Leucine-rich repeat Receptor containing a Pyrin domain 3 (NLRP3) inflammasomes are pro-inflammatory signalling complexes that were found in 2002. In addition to pathogens and other extracellular threats, they can be activated by various endogenous danger signals. The purpose of this study was to find out whether NLRP3 activation occurs in patients with sight-threatening forms of diabetic retinopathy (DR)...
March 8, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28271607/dissecting-microrna-dysregulation-in-age-related-macular-degeneration-new-targets-for-eye-gene-therapy
#10
REVIEW
Anne Louise Askou, Sidsel Alsing, Andreas Holmgaard, Toke Bek, Thomas J Corydon
MicroRNAs (miRNAs) are key regulators of gene expression in humans. Overexpression or depletion of individual miRNAs is associated with human disease. Current knowledge suggests that the retina is influenced by miRNAs and that dysregulation of miRNAs as well as alterations in components of the miRNA biogenesis machinery are involved in retinal diseases, including age-related macular degeneration (AMD). Furthermore, recent studies have indicated that the vitreous has a specific panel of circulating miRNAs and that this panel varies according to the specific pathological stress experienced by the retinal cells...
March 7, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28266797/reduced-number-of-relapses-of-human-leucocyte-antigen-b27-associated-uveitis-during-pregnancy
#11
LETTER
Fleurieke H Verhagen, Arthur M Braakenburg, Tessa Kremer, Julia Drylewicz, Aniki Rothova, Joke H de Boer
No abstract text is available yet for this article.
March 7, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28266180/serum-from-plasma-rich-in-growth-factors-regenerates-rabbit-corneas-by-promoting-cell-proliferation-migration-differentiation-adhesion-and-limbal-stemness
#12
Jaime Etxebarria, Sara Sanz-Lázaro, Raquel Hernáez-Moya, Vanesa Freire, Juan A Durán, María-Celia Morales, Noelia Andollo
PURPOSE: To evaluate the regenerating potential and the mechanisms through which the autologous serum derived from plasma rich in growth factors (s-PRGF) favours corneal wound healing in vitro and in vivo. METHODS: We compared the effect of various concentrations of s-PRGF versus fetal bovine serum (FBS) and control treatment in rabbit primary corneal epithelial and stromal cells and wounded rabbit corneas. Cell proliferation was measured using an enzymatic colorimetric assay...
March 7, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28266178/surgical-management-of-limbal-dermoids-10-year-review
#13
LETTER
Yong Yao, Ming Zhi Zhang, Vishal Jhanji
No abstract text is available yet for this article.
March 7, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28266152/macular-cystic-changes-as-predictive-factor-for-the-recurrence-of-macular-oedema-in-branch-retinal-vein-occlusion
#14
Eric Tilgner, Maiara Dalcegio Favretto, Maria Tuisl, Peter Wiedemann, Matus Rehak
AIM: To evaluate the role of small cystic macular changes as a prognostic factor for the recurrence of macular oedema (ME) in patients with branch retinal vein occlusion (BRVO) treated with anti-VEGF drugs. METHODS: We performed retrospective chart analysis of 116 patients treated with intravitreal injection of ranibizumab (IVR) or bevacizumab (IVB) for ME secondary to BRVO. At the baseline and monthly follow-up visits over a period of 12 months, a comprehensive ophthalmologic examination including best-corrected visual acuity (BCVA) and volume scan of macula using Spectral domain optical coherence tomography (SD-OCT) were performed...
March 7, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28266151/familial-vitreous-amyloidosis-resulting-from-transthyretin-variant-gly83arg
#15
LETTER
Bing Xie, Shan-Jun Cai, Mo Jiang, Hong Li, Gang Su
No abstract text is available yet for this article.
March 7, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28266150/two-year-results-of-microcatheter-assisted-trabeculotomy-in-paediatric-glaucoma-a-randomized-controlled-study
#16
Yasmine El Sayed, Ghada Gawdat
PURPOSE: To compare the outcomes of microcatheter-assisted circumferential trabeculotomy to standard rigid probe trabeculotomy in childhood glaucomas. METHODS: Eyes of children requiring trabeculotomy for primary congenital or secondary paediatric glaucoma were randomized to undergo either trabeculotomy using the Glaucolight illuminated microcatheter, or a rigid probe trabeculotomy. Complete success was defined as an intraocular pressure (IOP) of <18 mmHg without medications...
March 7, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28266143/the-influence-of-donor-factors-on-corneal-organ-culture-contamination
#17
Anja K Gruenert, Katja Rosenbaum, Gerd Geerling, Thomas A Fuchsluger
PURPOSE: To evaluate the contamination rate and the corresponding spectrum of microbes and to identify donor risk factors for corneal organ culture contaminations. METHODS: A total of 3306 organ-cultured donor corneas were included in the study. We performed a retrospective database analysis to evaluate donor factors such as gender, age, death-to-explantation interval (DEI), procurement site and cause of death and to determine their influence on donor cornea contaminations...
March 7, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28261932/aqueous-chlorhexidine-is-an-effective-alternative-to-povidone-iodine-for-intravitreal-injection-prophylaxis
#18
LETTER
Carmen L Oakley, Brendan J Vote
No abstract text is available yet for this article.
March 6, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28258620/changes-in-lipidomic-profile-of-aqueous-humour-in-fuchs-endothelial-dystrophy
#19
Javier Cabrerizo, Javier Aritz Urcola, Elena Vecino, Gerrit Melles
PURPOSE: To identify and determine differences in lipid profile of aqueous humour (AH) in patients with Fuchs endothelial corneal dystrophy (FECD). METHODS: Lipidomic profile of eight AH samples of FECD patients and 10 control samples was analysed. Patients with previous history of anterior segment surgery, anterior segment pathology or intraocular injections were excluded. Topical ocular medications within the last 6 months were reported. Aqueous humour (AH) was obtained during the first step of Descemet membrane endothelial keratoplasty in FECD patients and during refractive lensectomy in the control group...
March 4, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28251836/time-spent-in-outdoor-activities-in-relation-to-myopia-prevention-and-control-a-meta-analysis-and-systematic-review
#20
REVIEW
Shuyu Xiong, Padmaja Sankaridurg, Thomas Naduvilath, Jiajie Zang, Haidong Zou, Jianfeng Zhu, Minzhi Lv, Xiangui He, Xun Xu
Outdoor time is considered to reduce the risk of developing myopia. The purpose is to evaluate the evidence for association between time outdoors and (1) risk of onset of myopia (incident/prevalent myopia); (2) risk of a myopic shift in refractive error and c) risk of progression in myopes only. A systematic review followed by a meta-analysis and a dose-response analysis of relevant evidence from literature was conducted. PubMed, EMBASE and the Cochrane Library were searched for relevant papers. Of the 51 articles with relevant data, 25 were included in the meta-analysis and dose-response analysis...
March 2, 2017: Acta Ophthalmologica
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