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Acta Ophthalmologica

Anouk W Vaes, Martijn A Spruit, Jan Theunis, Nandu Goswami, Lowie E Vanfleteren, Frits M E Franssen, Emiel F M Wouters, Patrick De Boever
Chronic obstructive pulmonary disease (COPD) is a complex disease with many patients suffering from cardiovascular comorbidity. However, cardiovascular diseases remain often undiagnosed in COPD. Assessment of the retinal microvasculature can provide value in cardiovascular profiling of these patients. Retinal microvascular assessment carried out via a noninvasive eye exam represents an easy to use tool when examining patients with COPD. The purpose of this review was to provide an overview of studies assessing structural and functional changes in the retinal microvasculature of patients with COPD...
May 16, 2018: Acta Ophthalmologica
Jana Stefanickova, Jose Cunha-Vaz, Michael Ulbig, Ian Pearce, Alvaro Fernández-Vega Sanz, Panagiotis Theodossiadis, Laurent Kodjikian, Alexander Izmailov, Dominic Muston, Zdravko Vassilev, Benedicte Lamotte, Claudia Tückmantel, Sabine Friedl, Andreas Altemark, Hans-Jörg Schwarz, Todd Katz
PURPOSE: Antivascular endothelial growth factor agents are increasingly used in diabetic macular oedema (DME); however, there are few studies exploring their use in DME in real-world settings. METHODS: POLARIS was a noninterventional, multicentre study to monitor 12-month outcomes in patients starting ranibizumab treatment in routine practices. The primary outcome was mean change in visual acuity (VA) from baseline to month 12 (last observation carried forward approach)...
April 25, 2018: Acta Ophthalmologica
Zhongyun Yuan, Kai Zhuo, Qiang Zhang, Chun Zhao, Shengbo Sang
PURPOSE: In this article, we develop a dynamic Bayesian network (DBN) model to measure 3D visual fatigue. As far as our information goes, this is the first adaptation of a DBN structure-based probabilistic framework for inferring the 3D viewer's state of visual fatigue. METHODS: Our measurement focuses on the interdependencies between each factor and the phenomena of visual fatigue in stereoscopy. Specifically, the implementation of DBN with using multiple features (e...
April 25, 2018: Acta Ophthalmologica
Gerardo Pedro García-García, Magdalena Martínez-Rubio, Medina-Azahara Moya-Moya, Juan José Pérez-Santonja, Julio Escribano
PURPOSE: To identify the spectrum of disease-causing CYP4V2 variants in Spanish patients with clinically diagnosed Bietti crystalline dystrophy (BCD) over an 8-year period and to analyse the phenotype-genotype correlation of the identified variants. METHODS: Four unrelated Spanish probands with a clinical diagnosis of BCD were recruited. Ophthalmological examination included visual acuity (VA), slit lamp examination, in vivo corneal confocal microscopy, funduscopy and fluoresceinic angiography...
April 25, 2018: Acta Ophthalmologica
Nanna Staehr Jakobsen, Dorte Ancher Larsen, Toke Bek
PURPOSE: Diabetic maculopathy can be treated with intravitreal injection of vascular endothelial growth factor (VEGF) inhibitors. However, the therapy is not effective in all patients, and it would be desirable to have parameters for differentiating patients who will benefit from treatment from those who will not. Retinal fixation has been shown to be impaired in patients with low visual acuity (VA) secondary to macular disease, but the changes in fixational eye movements after anti-VEGF treatment for diabetic maculopathy have not been investigated...
April 24, 2018: Acta Ophthalmologica
Jari Radros, Charlotta All-Eriksson, Niklas Pal, Stefan Holm, Stefan Seregard, Michael Söderman, Fabian Arnberg, Staffan Holmin
No abstract text is available yet for this article.
April 24, 2018: Acta Ophthalmologica
Jasmine Andersson, Mikael Hofsli, Nina Jacobsen
No abstract text is available yet for this article.
April 22, 2018: Acta Ophthalmologica
Claudia Taipale, Emil J Holmström, Raimo Tuuminen
No abstract text is available yet for this article.
April 20, 2018: Acta Ophthalmologica
Shengjie Li, Mingxi Shao, Danhui Li, Binghua Tang, Wenjun Cao, Xinghuai Sun
PURPOSE: It has been hypothesised that uric acid (UA) has a protective effect against oxidative damage in the central nervous system. Therefore, we investigated serum UA concentrations in patients with primary open-angle glaucoma (POAG) and explored the relationship between serum UA concentration and glaucoma severity. METHODS: This prospective, cross-sectional, case-control study was conducted in 163 POAG patients and 103 normal controls. Clinical and demographic information was obtained from the medical data platform of the Eye & ENT Hospital of Fudan University, Shanghai, China...
April 19, 2018: Acta Ophthalmologica
Azu Suzuki, Yoji Takano, Yasutaka Ando, Junko Ogawa, Masahiro Ishida, Akiyasu Baba, Yutaka Imamura
No abstract text is available yet for this article.
April 19, 2018: Acta Ophthalmologica
Toshifumi Yamashita, Taiji Sakamoto, Hiroto Terasaki, Masanori Iwasaki, Yoko Ogushi, Fumiki Okamoto, Masaru Takeuchi, Tsutomu Yasukawa, Yoshihiro Takamura, Nahoko Ogata, Yumiko Nakamura
The purpose of this study was to compare the surgical outcomes of vitrectomy with conventional internal limiting membrane (C-ILM) peeling to that with the inverted ILM (I-ILM) flap technique for large macular holes (MHs). This was a retrospective chart review of consecutive cases with a large MH at nine hospitals in Japan. Among the 1342 eyes, 165 eyes of 165 cases met the inclusion criteria. The results for medium-large MHs with a diameter 400-550 μm were compared to that of eyes with an extra-large MH with a diameter >550 μm...
April 19, 2018: Acta Ophthalmologica
Jana C Riedl, Joanna Wasielica-Poslednik, Veronika Weyer-Elberich, Urs Vossmerbaeumer, Norbert Pfeiffer, Walter Lisch, Adrian Gericke
PURPOSE: The major goal of this study was to test the hypothesis that in patients with peripheral hypertrophic subepithelial corneal opacification (PHSCO), visualization of corneal vessels is better with optical coherence tomography angiography (OCTA) than with conventional slit lamp microphotography. METHODS: Patients with PHSCO were included in this prospective study. The corneal findings were photographed using a slit lamp camera (Haag Streit BM 900® ) and visualized with anterior-segment OCT (Optovue XR Avanti, Fremont, California, USA)...
April 19, 2018: Acta Ophthalmologica
Alberto Modenese, Fabriziomaria Gobba
Cataract is currently the primary cause of blindness worldwide, and one of its main risk factors is solar ultraviolet radiation exposure. According to the localization of lens opacities, three main subtypes of cataract are recognized: nuclear, cortical and posterior subcapsular cataract. One of the main determinants of individual long-term solar radiation exposure is outdoor work. We systematically reviewed scientific literature from the last 20 years to update the recent development of research on the risk of cataract in outdoor workers and on the specific subtypes involved, also investigating the methods applied to evaluate the occupational risk...
April 16, 2018: Acta Ophthalmologica
Joel Hanhart, Doron S Comaneshter, Shlomo Vinker
PURPOSE: To analyse the mortality associated with intravitreal injections of bevacizumab for age-related macular degeneration (AMD) in patients previously diagnosed with stroke or transient ischaemic attack (TIA). METHODS: We reviewed bevacizumab-treated AMD patients with a diagnosis of stroke or TIA prior to their first bevacizumab injection (n = 948). Those patients, naïve to any anti-vascular endothelial growth factor (anti-VEGF) at the time of stroke/TIA, were then compared to age- and gender-matched patients who had a stroke/TIA at the same time and had never been exposed to anti-VEGF...
April 16, 2018: Acta Ophthalmologica
Paolo Lanzetta, Alan F Cruess, Salomon Y Cohen, Jason S Slakter, Todd Katz, Olaf Sowade, Oliver Zeitz, Christiane Ahlers, Paul Mitchell
PURPOSE: Identify predictors for response to anti-vascular endothelial growth factor (VEGF) therapy in patients with neovascular (wet) age-related macular degeneration (nAMD). METHODS: Retrospective, post hoc analysis of VIEW 1/2. Patients were randomized 1:1:1:1 to 0.5 mg intravitreal aflibercept (IVT-AFL) injection every 4 weeks (0.5q4); 2 mg IVT-AFL every 4 weeks (2q4); 2 mg IVT-AFL every 8 weeks (2q8) after an initial three injections at weeks 0, 4 and 8 or 0...
April 16, 2018: Acta Ophthalmologica
Steffen Hamann, Lasse Malmqvist, Fiona Costello
Optic disc drusen (ODD) are acellular deposits located in the optic nerve head of up to 2.4% of the population. They may develop as by-products of impaired axonal metabolism in genetically predisposed individuals, in whom a narrow scleral canal is hypothesized to play a role. Although ODD are often considered as benign innocent bystanders, recognized as part of a routine ophthalmological examination, the vast majority of patients with ODD have visual field defects. Optic disc drusen (ODD)-associated complications with severe visual loss, most often due to anterior ischaemic optic neuropathy, are also known to occur...
April 16, 2018: Acta Ophthalmologica
Ahmad Sahraravand, Anna-Kaisa Haavisto, Juha M Holopainen, Tiina Leivo
PURPOSE: To describe epidemiology, causes, treatments and outcomes of all ocular injuries in southern Finland among people aged 61 and older. METHODS: All new ocular trauma patients, admitted to the Helsinki University Eye Hospital, during 1 year in 2011-2012. The data were from hospital records and prospectively from patient questionnaires. The follow-up time was 3 months. RESULTS: The incidence for ocular injuries among the elderly was 38/100 000/year...
April 16, 2018: Acta Ophthalmologica
Marta Zola, Irini Chatziralli, Deepthy Menon, Roy Schwartz, Phil Hykin, Sobha Sivaprasad
PURPOSE: To determine the evolution of fundus autofluorescence (FAF) patterns in chronic central serous chorioretinopathy (CSCR) over time. METHODS: We retrospectively studied the changes in FAF patterns over time in 157 eyes of 112 patients with chronic CSCR using the Heidelberg Retina Angiography with a 488-nm excitation light and a 500-nm cutoff barrier filter. RESULTS: The mean duration of follow-up was 37.2 months. The most common baseline pattern was that of granular hypoautofluorescence (51...
April 15, 2018: Acta Ophthalmologica
Dieter Franz Rabensteiner, Haleh Aminfar, Ingrid Boldin, Gerold Schwantzer, Jutta Horwath-Winter
PURPOSE: The purpose of this study was to assess the prevalence of meibomian gland dysfunction (MGD) and its association with tear film and ocular surface parameters in an Austrian clinical population of dry eye patients. METHODS: The records of 1372 consecutive patients from a dry eye unit were analysed retrospectively. Symptoms and objective tear film and ocular surface parameters were evaluated. Patients were classified into pure MGD, pure aqueous tear deficiency (ATD), MGD combined with ATD, pure anterior blepharitis (AB), Sjogren's syndrome (SS) without MGD and SS together with MGD...
April 15, 2018: Acta Ophthalmologica
José M Pérez-Trullén, Francisco J Ascaso, María J Auría
PURPOSE: The aim of this article is to 'determine' the scope of Goya's eyesight difficulties and assess the extent to which those difficulties might explain his style of painting in the last years of his life. METHODS: We analyse the correspondence and late works of the Aragonese painter Francisco de Goya y Lucientes (1746-1828), who has been admired for his use of colour, his energetic loose brushstrokes, his disregard for details and his bold compositions, as well as for his different artistic styles throughout his life...
April 15, 2018: Acta Ophthalmologica
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