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Acta Ophthalmologica

Esma Islamaj, René J Wubbels, Peter W T de Waard
PURPOSE: To compare a Baerveldt implant and trabeculectomy with respect to intraocular pressure (IOP) and failure rate at 1 year of follow-up. Secondary outcomes are pharmacological therapy and complications at 1 year of follow-up. METHODS: This was a randomized, comparative study. A total of 119 glaucoma patients without previous ocular surgery were included at the Rotterdam Eye Hospital, the Netherlands. One eye of each subject was randomized to either a Baerveldt glaucoma drainage device (BGI) or trabeculectomy (TE)...
July 19, 2018: Acta Ophthalmologica
Masaki Tanito, Koji Nitta, Maki Katai, Yasushi Kitaoka, Yu Yokoyama, Kazuko Omodaka, Tomoko Naito, Takehiro Yamashita, Shiro Mizoue, Aiko Iwase, Toru Nakazawa
AIMS: The Glaucoma Stereo Analysis Study (GSAS) is a multicentre collaborative study of the characteristics of glaucomatous optic disc morphology using a stereo fundus camera. Using the GSAS dataset, we previously established a formula for predicting different appearances of glaucomatous optic discs, although the formula lacked validation in an independent dataset. In this study, the formula was validated in another testing dataset. SUBJECTS AND METHODS: Testing dataset contained three-dimensionally analysed optic disc topographic parameters from 93 eyes with primary open-angle glaucoma; six topographic parameters (temporal and nasal rim-disc ratios, mean cup depth, height variation contour, disc tilt angle and rim decentring absolute value) were used for predicting different appearances of glaucomatous optic discs...
July 18, 2018: Acta Ophthalmologica
Kalpana Rose, Hatem Krema, Priya Durairaj, Wantanee Dangboon, Yael Chavez, Susith I Kulasekara, Christopher Hudson
PURPOSE: To investigate retinal blood flow and oxygen saturation changes in patients diagnosed with retinopathy following plaque radiation treatment to treat choroidal melanoma. METHODS: Eight patients (mean age 55.75 years, SD 12.58 years) who have developed unilateral ischaemic radiation-related retinopathy as confirmed by wide-field fluorescein angiography were recruited for the study. The fellow eye with no other ocular or retinal pathology was used as control...
July 11, 2018: Acta Ophthalmologica
Milo van Hoefen Wijsard, Michiel Haan, Eelco Rietveld, Laurentius J van Rijn
PURPOSE: To compare the use of human donor sclera with bovine pericardium as patch graft material for a glaucoma drainage device (GDD), with respect to the incidence of tube exposure, and to study the role of a drainage suture. METHODS: All GDD surgeries between 2010 and 2014 performed at the VU Medical Center were examined in this comparative, retrospective cohort study. A total of 244 cases were included; 163 in the human donor sclera cohort and 81 in the bovine pericardium cohort with a median follow-up of 31 and 36 months, respectively...
July 10, 2018: Acta Ophthalmologica
M Reza Razeghinejad
No abstract text is available yet for this article.
June 28, 2018: Acta Ophthalmologica
Jasmine Andersson, Mikael Hofsli, Uffe Lomholt Gade, Steffen Heegaard, Anton Pottegård
PURPOSE: Acute infectious conjunctivitis is a common disease. While usually self-limiting, children often receive treatment to be accepted back into nursery, day care or school. We aimed to describe trends in the utilization of topical ocular antibiotics in young children aged 0-4 years in Denmark, Norway and Sweden. METHODS: Using individual-level data from the Danish National Prescription Registry (2000-2015), we provided detailed descriptions of treatment patterns at the individual level, stratified by age (0-1 years, 2-4 years) and antibiotic substance...
June 9, 2018: Acta Ophthalmologica
Shiqiong Xu, Hong Yu, Guohui Fu, Xianqun Fan, Renbing Jia
PURPOSE: A limited number of therapies are available for patients with metastatic eyelid sebaceous carcinoma (SC). Programmed death receptor Ligand 1 (PD-L1) expression and its clinical significance in sebaceous cell carcinoma are presently unknown. This study aimed to evaluate the expression level of PD-L1 in SC. METHODS: This single centre, retrospective, and comparative study was conducted at the Ninth People's Hospital between August 1, 2013 and September 1, 2016...
June 4, 2018: Acta Ophthalmologica
Francesco Semeraro, Andrea Russo, Francesco Morescalchi, Elena Gambicorti, Sara Vezzoli, Francesco Parmeggiani, Mario R Romano, Ciro Costagliola
PURPOSE: To evaluate the inflammation associated with the use of standard silicone oil (polydimethylsiloxane; PDMS) and heavy silicone oil (HSO) Densiron-68™ in patients undergoing vitrectomy for retinal detachment. MATERIALS AND METHODS: A prospective study was performed involving 35 patients scheduled to undergo vitrectomy for retinal detachment. Patients received PDMS or Densiron-68™ HSO according to superior or inferior retinal localization of the tears, respectively...
June 4, 2018: Acta Ophthalmologica
Hüseyin Baran Özdemir, Ayşe Kalkancı, Kamil Bilgihan, Pınar Uyar Göçün, Betül Öğüt, Funda Karakurt, Merve Erdoğan
PURPOSE: To compare the antifungal efficacy of corneal collagen cross-linking with photoactivated riboflavin (PACK-CXL) and voriconazole in experimental Fusarium solani and Candida albicans keratitis models. METHODS: Sixty-four corneas of 32 New Zealand rabbits were included and divided into two main groups. Intrastromal injection of Fusarium and Candida suspensions was performed, and it was observed that keratitis was formed on the third day. Both groups were randomly separated into the following four groups: control, PACK-CXL, voriconazole and PACK-CXL combined with voriconazole...
June 4, 2018: Acta Ophthalmologica
Jan C van Meurs, Jaap T J van Dissel
No abstract text is available yet for this article.
June 4, 2018: Acta Ophthalmologica
Mari Elshout, Carroll A B Webers, Margriet I van der Reis, Jan S A G Schouten
PURPOSE: Ophthalmologists increasingly depend on new drugs to advance their treatment options. These options are limited by restraints on reimbursements for new and expensive drugs. These restraints are put in place through health policy decisions based on cost-effectiveness analyses (CEA). Cost-effectiveness analyses need to be valid and of good quality to support correct decisions to create new treatment opportunities. In this study, we report the quality, validity and usefulness of CEAs for therapies for nAMD...
June 4, 2018: Acta Ophthalmologica
Afrouz Ahmadzadeh, Michael Larsen, Nina Jacobsen, Wael Soliman
No abstract text is available yet for this article.
June 4, 2018: Acta Ophthalmologica
Tyler Hyungtaek Rim, Sang Yeop Lee, Hyoung Won Bae, Gong Je Seong, Sung Soo Kim, Chan Yun Kim
PURPOSE: To evaluate the risk of open-angle glaucoma among patients with diabetes. METHODS: This retrospective propensity score-matched cohort study included patients with diabetes and a matched comparison group from the Korean National Health Insurance Service National Health Screening Cohort, which includes approximately 500 000 adults aged ≥40 years. Nondiabetes group was matched to diabetes group in a 1:1 ratio using a propensity score based on age, sex, comorbidities, antihypertensive medication use and medical care visits...
June 4, 2018: Acta Ophthalmologica
Kaustubh Mulay, Peter K Rasmussen, Ekta Aggarwal, Santosh G Honavar, Steffen Heegaard
PURPOSE: Tumours of the accessory lacrimal glands (ALGs) are rare and need to be differentiated from other tumours involving the eyelids and caruncle. We report on a consecutive series of patients with ALG tumours and describe the clinical characteristics. METHODS: A retrospective case series including all patients who were operated for ALG tumours at two different centres. RESULTS: The study included 27 patients diagnosed with ALG tumours...
May 31, 2018: Acta Ophthalmologica
Kathleen A Regan, Teddy S Youn, Siva S R Iyer
No abstract text is available yet for this article.
May 31, 2018: Acta Ophthalmologica
Vasiliki Zygoura, Rénuka S Birbal, Korine van Dijk, Jack S Parker, Lamis Baydoun, Isabel Dapena, Gerrit R J Melles
No abstract text is available yet for this article.
May 31, 2018: Acta Ophthalmologica
Jose I Belda, Jordi Loscos-Arenas, Andre Mermoud, Esther Lozano, Elisa D'Alessandro, Gema Rebolleda, Iñaki Rodriguez-Agirretxe, Maribel Canut, Pedro P Rodriguez-Calvo
PURPOSE: To compare the supraciliary versus intrascleral implantation of the hema implant (Esnoper V-2000) in terms of the efficacy and safety in nonpenetrating deep sclerectomy (NPDS). PATIENTS AND METHODS: Prospective, randomized, unmasked, competitive and multicenter clinical trial. Eighty-three eyes from 83 patients suffering from open-angle glaucoma (40 males, 43 females) were enrolled and followed up for 12 months. Main outcome measures were best-corrected visual acuity (BCVA), intraocular pressure (IOP), perimetry (mean defect, MD and Visual Field Index, VFI), pachymetry, number of antiglaucoma medications and analysis of blebs according Moorfields Bleb Grading...
May 31, 2018: Acta Ophthalmologica
Stanislao Rizzo, Alfonso Savastano, Lucia Finocchio, Maria Cristina Savastano, Neha Khandelwal, Rupesh Agrawal
PURPOSE: To study the structural changes in the choroid using swept-source (SS) optical coherence tomography (OCT), a tool for the choroidal vascularity index (CVI) following epiretinal membrane removal. METHODS: Fifty-two eyes of 26 patients were evaluated in this prospective, single-centre, observational study. Twenty-six eyes underwent vitrectomy for epiretinal membrane removal (VT-group), and the control group consisted of 26 corresponding fellow eyes (F-group)...
May 31, 2018: Acta Ophthalmologica
Christian Wertheimer, Alexander Kueres, Jakob Siedlecki, Christian Braun, Stefan Kassumeh, Armin Wolf, Wolfgang Mayer, Claudia Priglinger, Siegfried Priglinger, Kirsten Eibl-Lindner
PURPOSE: Posterior capsule opacification (PCO) occurs as a common complication after cataract surgery. Erlotinib is an inhibitor of the epidermal growth factor-Receptor and reduces critical cellular events leading to PCO. In this in vitro study, Erlotinib-modified intraocular lenses (IOLs) employed as a drug delivery device have been evaluated for PCO prevention. METHODS: The IC50 concentration of Erlotinib was determined by using FHL-124 cells. For the human capsular bag model, 40 cadaver eyes underwent sham cataract surgery...
May 31, 2018: Acta Ophthalmologica
Katherine Hutchins, Alon Harris, Joseph Thomas, Sameerah Alkhairy, Alice Chandra Verticchio Vercellin, Aaditya Shah, Brent Siesky
No abstract text is available yet for this article.
May 31, 2018: Acta Ophthalmologica
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