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Acta Ophthalmologica

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https://www.readbyqxmd.com/read/30232841/effect-of-funding-source-on-reporting-bias-in-studies-of-intravitreal-anti-vascular-endothelial-growth-factor-therapy-for-retinal-vein-occlusion
#1
Michael J Venincasa, Ajay E Kuriyan, Jayanth Sridhar
PURPOSE: To examine the relationship between industry funding and outcome reporting bias in high-quality studies investigating the use of intravitreal anti-vascular endothelial growth factor (VEGF) agents for patients with macular oedema secondary to branch or central retinal vein occlusion (RVO). METHODS: This systematic review in PubMed and Ovid MEDLINE examined all randomized clinical trials and meta-analyses published in journals with impact factor of ≥2 that investigated effectiveness of intravitreal anti-VEGF therapy in patients with RVO...
September 19, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/30225941/role-of-corneal-nerves-in-ocular-surface-homeostasis-and-disease
#2
REVIEW
Marc Labetoulle, Christophe Baudouin, Margarita Calonge, Jesús Merayo-Lloves, Kostas G Boboridis, Yonca A Akova, Pasquale Aragona, Gerd Geerling, Elisabeth M Messmer, José Benítez-Del-Castillo
Corneal nerves are key components of the physiological system that controls ocular surface homeostasis. The cornea is primarily innervated by the ophthalmic branch of the trigeminal nerves (cranial nerve V), which distend bilaterally from the pons. The nasociliary branch (afferent) of the ophthalmic nerve is sensory for cornea, eyelid and conjunctiva. These nerve fibres play a role in sensing temperature, chemical and mechanical stimuli, and pain, whereas, branches of the facial nerve (cranial nerve VII) contain motor nerves that control blinking and autonomic (sympathetic and a paucity of parasympathetic) fibres that stimulate tear production and secretion via feedback loops between the ocular surface, lacrimal glands and brain...
September 17, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/30225863/improved-discrimination-between-normal-tension-and-primary-open-angle-glaucoma-with-advanced-vascular-examinations-the-leuven-eye-study
#3
João Barbosa-Breda, Karel Van Keer, Luis Abegão-Pinto, Vahid Nassiri, Geert Molenberghs, Koen Willekens, Evelien Vandewalle, Amândio Rocha-Sousa, Ingeborg Stalmans
PURPOSE: Vascular factors have been suggested to influence the development and progression of glaucoma. They are thought to be especially relevant for normal-tension glaucoma (NTG) patients. We aim to investigate which vascular factors, including advanced vascular examinations, better describe patients with NTG comparing to those with primary open-angle glaucoma (POAG). METHODS: The Leuven Eye Study database (182 NTG and 202 POAG patients; similar structural and functional damage) was used to compute three multivariate logistic regression models: a conventional model (conventional parameters only, including vascular-related self-reported phenomena, such as migraine or peripheral vasospasm); an advanced vascular model (advanced vascular parameters only: colour Doppler imaging (CDI), retinal oximetry, ocular pulse amplitude and choroidal thickness); and a global model, in which both types of parameters were allowed...
September 17, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/30218499/optic-nerve-head-blood-flow-regulation-during-changes-in-arterial-blood-pressure-in-patients-with-primary-open-angle-glaucoma
#4
Ahmed M Bata, Klemens Fondi, Katarzyna J Witkowska, René M Werkmeister, Anton Hommer, Clemens Vass, Hemma Resch, Doreen Schmidl, Alina Popa-Cherecheanu, Jacqueline Chua, Gerhard Garhöfer, Leopold Schmetterer
PURPOSE: Abnormal autoregulation of optic nerve head blood flow (ONHBF) has been postulated to play an important role in primary open-angle glaucoma (POAG). We used laser Doppler flowmetry (LDF) to estimate quantitatively the ONHBF and compared ONHBF autoregulation between glaucoma patients and healthy controls during isometric exercise. METHODS: Forty patients with POAG and 40 healthy age- and sex-matched subjects underwent three periods of isometric exercise, each consisting of 2 min of handgripping...
September 14, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/30218494/the-rim-area-of-the-optic-nerve-head-assessed-with-heidelberg-retina-tomography-is-smaller-in-prematurely-born-children-than-in-children-born-at-term
#5
Hanna Åkerblom, Gerd Holmström, Eva Larsson
PURPOSE: To examine the optic nerve head with Heidelberg tomography (HRT) in prematurely born school-age children and compare them to children born at term. METHODS: Sixty-three 5-16-year-old children born with a gestational age (GA) of ≤32 weeks were included in the study and compared to 54 children of the same age, born at term. In the preterm group, 29 children had had retinopathy of prematurity (ROP) and nine children had neurological complications. The optic nerve head was assessed with HRT...
September 14, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/30218493/increased-risk-of-neovascular-age-related-macular-degeneration-in-patients-with-herpes-zoster-ophthalmicus-a-retrospective-cohort-study
#6
LETTER
Jau-Der Ho, Herng-Ching Lin, Li-Ting Kao
No abstract text is available yet for this article.
September 14, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/30218490/binocular-vision-alterations-after-refractive-and-cataract-surgery-a-review
#7
REVIEW
María García-Montero, César Albarrán Diego, Nuria Garzón-Jiménez, Rafael J Pérez-Cambrodí, Esther López-Artero, Juan Carlos Ondategui-Parra
To review binocular and accommodative disorders documented after corneal or intraocular refractive surgery, in normal healthy prepresbyopic patients. A bibliographic revision was performed; it included works published before 1st July 2017 where accommodation and/or binocularity was assessed following any type of refractive surgical procedure. The search in Pubmed yielded 1273 papers, 95 of which fulfilled the inclusion criteria. Few publications reporting binocular vision and/or accommodative changes after refractive surgery in normal subjects were found...
September 14, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/30218489/analysis-of-the-current-preschool-vision-screening-in-denmark
#8
Lisbeth Sandfeld, Hanne Weihrauch, Gitte Tubaek
PURPOSE: To analyse the current vision screening programme for children attending school with respect to identifying children with significant refractive errors. METHODS: A total of 950 children from the municipality of Roskilde, Denmark, were invited to participate in a cross-sectional study of vision screening. 447 children aged 4.5-7 years participated in the study. The children completed a vision screening and a full eye examination. The vision screening consisted of visual acuity at distance (VA), visual acuity at distance with +2...
September 14, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/30218484/electroretinogram-abnormalities-in-nonanterior-childhood-uveitis
#9
Anna H Brouwer, Maria M van Genderen, Gerard C de Wit, Joke H de Boer
PURPOSE: A major point of concern in uveitis is the development of irreversible retinal changes after inflammation. In this study, we assess how nonanterior childhood uveitis affects retinal function using full-field electroretinography (ERG). METHODS: Cross-sectional study. ERGs of 63 uveitis eyes (33 children) were measured according to extended International Society for Clinical Electrophysiology of Vision (ISCEV) protocols. ERG abnormalities were investigated in relation to the following clinical parameters: demographics, uveitis characteristics, including severity of inflammation, treatment, best corrected visual acuity (BCVA), cystoid macular oedema (CME) on optical coherence tomography and fluorescein angiography score...
September 14, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/30218483/neuropeptide-y-treatment-induces-retinal-vasoconstriction-and-causes-functional-and-histological-retinal-damage-in-a-porcine-ischaemia-model
#10
Anders T Christiansen, Nina B Sørensen, Kristian A Haanes, Frank W Blixt, Morten la Cour, Karin Warfvinge, Kristian Klemp, David P D Woldbye, Jens F Kiilgaard
PURPOSE: To investigate the effects of intravitreal neuropeptide Y (NPY) treatment following acute retinal ischaemia in an in vivo porcine model. In addition, we evaluated the vasoconstrictive potential of NPY on porcine retinal arteries ex vivo. METHODS: Twelve pigs underwent induced retinal ischaemia by elevated intraocular pressure clamping the ocular perfusion pressure at 5 mmHg for 2 hr followed by intravitreal injection of NPY or vehicle. After 4 weeks, retinas were evaluated functionally by standard and global-flash multifocal electroretinogram (mfERG) and histologically by thickness of retinal layers and number of ganglion cells...
September 14, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/30218481/adherence-to-a-mediterranean-diet-lifestyle-and-age-related-macular-degeneration-the-coimbra-eye-study-report-3
#11
Miguel Raimundo, Filipe Mira, Maria da Luz Cachulo, Patrícia Barreto, Luísa Ribeiro, Cláudia Farinha, Inês Laíns, Sandrina Nunes, Dalila Alves, João Figueira, Bénédicte Mj Merle, Cécile Delcourt, Lèlita Santos, Rufino Silva
PURPOSE: To characterize the lifestyle and nutritional risk profile associated with the Mediterranean diet in a Portuguese population with and without age-related macular degeneration (AMD). METHODS: Nested case-control study (n = 883) within the Coimbra Eye Study, including 434 subjects with AMD and 449 age- and sex-matched subjects without AMD. All enrolled subjects underwent a full risk assessment, including lifestyle-related risk factors and a thorough food frequency questionnaire...
September 14, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/30207075/estimating-heritability-of-refractive-error-in-koreans-the-korea-national-health-and-nutrition-examination-survey
#12
Ho Sik Hwang, Gyeong-Hun Park, Jang Won Heo, Mee Kum Kim, Seung-Hee Baek, Bum-Joo Cho
PURPOSE: To estimate the familial correlation and heritability of refractive error in general Korean population. METHODS: From the Korea National Health and Nutrition Examination Survey, 13 258 subjects of 7920 families, who were aged ≥19 years, were included in the study. Using variance components analysis, the additive genetic effect, or heritability, and the common and unique environmental effects on refractive error were examined, adopting common environments shared by cohabiting family or by siblings...
September 12, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/30207073/quality-of-life-and-participation-of-young-adults-with-a-visual-impairment-aged-18-25-years-comparison-with-population-norms
#13
Ellen Bernadette Maria Elsman, Gerardus Hermanus Maria Bartholomeus van Rens, Ruth Marie Antoinette van Nispen
PURPOSE: To compare health-related quality of life and participation of visually impaired young adults with normative groups, and to explore severity of vision loss and its association with participation and quality of life. METHODS: Young adults aged 18-25 years (n = 172) registered at two Dutch low vision rehabilitation organizations completed the Short Form Health Survey (SF-36), EuroQol-5 Dimensions (EQ-5D), Impact on Participation and Autonomy (IPA) and Low Vision Quality of Life questionnaire (LVQOL)...
September 11, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/30207069/impact-of-corneal-disease-from-patients-and-ophthalmologists-perspectives
#14
LETTER
Eline Vreijsen, Ellen Bernadette Maria Elsman, Ruth van Nispen, Rudy Nuijts, Ger van Rens
No abstract text is available yet for this article.
September 11, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/30203609/choroidal-blood-flow-after-the-first-intravitreal-ranibizumab-injection-in-neovascular-age-related-macular-degeneration-patients
#15
Benjamin Mottet, Florent Aptel, Martial Henri Geiser, Ruxandra Hera, Thierry Zhou, Ahmed Almanjoumi, Viviane Vinh, Christophe Chiquet
PURPOSE: To analyse choroidal blood flow (ChBF) changes after the first intravitreal ranibizumab injection in naïve, age-related macular degeneration (ARMD) patients. METHODS: Subfoveal ChBF was assessed by laser Doppler flowmetry (LDF) in newly diagnosed ARMD patients. Both treated and untreated eyes were assessed in each subject at each visit before the first intravitreal ranibizumab injection as well as 24 hr (day 1) and 7 days after (day 7). Central macular thickness (CMT), best-corrected visual acuity (BVCA), systemic haemodynamic parameters and LDF parameters were evaluated at each visit...
September 10, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/30203530/comparison-of-corneal-biomechanical-changes-after-refractive-surgery-by-noncontact-tonometry-small-incision-lenticule-extraction-versus-flap-based-refractive-surgery-a-systematic-review
#16
REVIEW
Pernille Raevdal, Jakob Grauslund, Anders Højslet Vestergaard
Corneal refractive surgery disrupts corneal integrity and reduces biomechanical stability in consequence of the beneficial refractive alteration. The minimal invasive cap-based refractive procedure, small-incision lenticule extraction (SMILE), has been proposed to affect corneal integrity less than flap-based procedures, due to the fibre-sparing incision of the strong anterior corneal lamellae. Flap-based procedures include laser-assisted in situ keratomileusis (LASIK), femtosecond laser-assisted in situ keratomileusis (FS-LASIK) and femtosecond lenticule extraction (FLEx)...
September 10, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/30203451/effect-of-mitochondrial-haplogroups-on-ranibizumab-response-in-neovascular-age-related-macular-degeneration-patients-a-pilot-study
#17
LETTER
Olivia Esteban, Francisco J Ascaso, Javier Mateo, Tania Calvo, Julio Montoya, Eduardo Ruiz-Pesini
No abstract text is available yet for this article.
September 10, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/30198106/a-strategy-for-oct-estimation-of-the-optic-nerve-head-pigment-epithelium-central-limit-inner-limit-of-the-retina-minimal-distance-pimd-2%C3%AF
#18
Camilla Sandberg Melin, Filip Malmberg, Per G Söderberg
PURPOSE: To develop a semi-automatic algorithm for estimation of pigment epithelium central limit-inner limit of the retina minimal distance averaged over 2π radians (PIMD-2π) and to estimate the precision of the algorithm. Further, the variances in estimates of PIMD-2π were to be estimated in a pilot sample of glaucomatous eyes. METHODS: Three-dimensional cubes of the optic nerve head (ONH) were captured with a commercial SD-OCT device. Raw cube data were exported for semi-automatic segmentation...
September 10, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/30198216/retinal-vascular-function-in-asymptomatic-individuals-with-a-positive-family-history-of-cardiovascular-disease
#19
Swathi Seshadri, Said E Karimzad, Hala Shokr, Doina Gherghel
PURPOSE: To compare retinal microvascular function in healthy individuals with and without a positive family history (FH) of cardiovascular disease (CVD). METHODS: Retinal vessel reactivity was assessed by means of dynamic retinal vessel analysis in 38 healthy subjects aged between 30 and 66 years with a positive FH of CVD and 37 age- and gender-matched control subjects. Other assessments included blood pressure (BP) profiles, blood glucose and lipid metabolism markers, Framingham risk scores (FRS), carotid intima-media thickness (c-IMT) and brachial flow-mediated dilation (FMD)...
September 9, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/30198182/development-and-testing-of-a-patient-derived-questionnaire-for-treatment-of-neovascular-age-related-macular-degeneration-dimensions-of-importance-in-treatment-of-neovascular-age-related-macular-degeneration
#20
Elma Jelin, Torbjørn Wisløff, Morten C Moe, Turid Heiberg
PURPOSE: Studies reporting on patient perspectives during treatment of neovascular age-related macular degeneration (nAMD) are limited. Thus, the aim of this study was to develop and test psychometric performance of a patient-derived questionnaire to capture important experiences during intravitreal treatment. METHODS: Patients (n = 44) with at least 3-month experience of intravitreal injection treatment for nAMD identified the dimensions of priority and also performed a weighting procedure to develop a score for comparison...
September 9, 2018: Acta Ophthalmologica
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