Nyam-Osor Chimge, Min-Hsuan Chen, Cu Nguyen, Yuqi Zhao, Xiwei Wu, Paulina Garcia Gonzalez, Heather Ogana, Samantha Hurwitz, Jia-Ling Teo, Xiaolong Chen, Juan Du, Victor Jin, Yong-Mi Kim, Masaya Ono, Rafael J Argüello, Michael Kahn
BACKGROUND AND OBJECTIVE: Disease relapse and therapy resistance remain serious impediments to treating cancer. Leukemia stem cells (LSC) are therapy resistant and the cause of relapse. A state of deep quiescence appears to enable cancer stem cells (CSC) to acquire new somatic mutations essential for disease progression and therapy resistance. Both normal hematopoietic stem cells (HSC) and LSC share many common features, thereby complicating the safe elimination of LSC. A recent study demonstrated that long lived normal oocytes exist without mitochondrial complex I (MC-1), expressing it in a developmentally regulated fashion, thereby mitigating their vulnerability to ROS...
September 6, 2023: Current Molecular Pharmacology