Subodh Kumar, Harvinder Singh, Manisha Prajapat, Phulen Sarma, Anusuya Bhattacharyya, Hardeep Kaur, Gurjeet Kaur, Nishant Shekhar, Karanveer Kaushal, Kalpna Kumari, Seema Bansal, Saniya Mahendiratta, Arushi Chauhan, Ashutosh Singh, Rahul Soloman Singh, Saurabh Sharma, Prasad Thota, Pramod Avti, Ajay Prakash, Anurag Kuhad, Bikash Medhi
NSP16 is one of the structural proteins of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) necessary for its entrance to the host cells. It exhibits 2'O-methyl-transferase (2'O-MTase) activity of NSP16 using methyl group from S-adenosyl methionine (SAM) by methylating the 5-end of virally encoded mRNAs and shields viral RNA, and also controls its replication as well as infection. In the present study, we used in silico approaches of drug repurposing to target and inhibit the SAM binding site in NSP16 using Food and Drug Administration (FDA)-approved small molecules set from Drug Bank database...
2023: Bioinformatics and Biology Insights