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Tissue Engineering. Part B, Reviews

Amani Basudan, Marwa Shaheen, Rob de Vries, Jeroen van den Beucken, John A Jansen, Hamdan Alghamdi
This meta-analysis was to systematically investigate all preclinical researches on the possible benefits of anti-osteoporotic drugs on titanium implants. Also, we performed a subgroup analysis to examine if the methods of drug delivery (systemic vs. local vs. surface coatings) or the types of anti-osteoporotic drug (anti-catabolic vs. anabolic) have more effect on bone-to-implant regeneration. A total of 116 articles (animal studies) were included. Poor reporting was assessed in the majority of the included studies...
September 7, 2018: Tissue Engineering. Part B, Reviews
Salma Mahzoon, Michael S Detamore
In the field of regenerative medicine, creating a biomaterial device with the potential alone to affect cellular fate is a desirable translational strategy. Native tissues and growth factors are attractive candidates to provide desired signals in a biomaterial environment. However, these molecules can have translational challenges such as high cost, complicated regulatory pathways, and/or limitations with reproducibility. In regenerative medicine, there is a burgeoning community of investigators who seek to overcome these challenges by introducing synthetic peptides to mimic the desirable signals provided by growth factors and tissue matrices...
September 6, 2018: Tissue Engineering. Part B, Reviews
Dimitrios Kouroupis, Clara Sanjurjo-Rodriguez, Elena Jones, Diego Correa
To date, the therapeutic efficacy of human mesenchymal stem cells (hMSCs) has been investigated in various clinical trials with moderate or in some cases inconsistent results. The still elusive reproducibility relates in part with constitutive differences in the cell preparation, translated into variable "cell potencies". Other factors include poor cell homing and survival, and age/disease-associated host tissue impairment. It is well accepted that within in vivo niches MSCs exist as heterogeneous cell populations with different stemness propensities and supportive functions...
August 31, 2018: Tissue Engineering. Part B, Reviews
Charlène Kichenbrand, Émilie Velot, Patrick Menu, Vanessa Moby
Mesenchymal stem cells have a lot of potential in regenerative medicine and mesenchymal stem cell-based therapies are currently explored in numerous research fields. Among these cells, deciduous or permanent dental pulp-mesenchymal stem cells represent a promising option in tissue engineering. This expectation is based on their capacity to self-renew, to repair various damaged tissues and organs due to their multipotency, as well as their ability to modulate immune system. They present other advantages such as the harvesting by a simple, painless and non-invasive procedure and the absence of ethical considerations...
August 29, 2018: Tissue Engineering. Part B, Reviews
Dongxu Ke, Sean Murphy
Bioprinting is a recently developed technology that has great potential to manufacture artificial tissues and organs for transplantation. Recent studies have demonstrated promising results of small-scale bioprinted tissues with vascular structure and signs of their particular tissue functions. However, the recreation of a complex and multifunctional vascular network, as well as the limitation of oxygen and nutrient diffusion, in a human-scale tissue are still challenges in the current stage of this technology...
August 21, 2018: Tissue Engineering. Part B, Reviews
Yaping Ma, Yinghong Zhou, Fujun Wu, Wenjun Ji, Xin Wang, Jun Zhang
Research regarding the intimate relationship between inflammation and coagulation in fracture hematoma has attracted increasing attention recently. However, the interaction of the two in the early fracture hematoma is not yet fully understood, especially the interplay between inflammatory and coagulation factor for hematoma structure. This review summarizes the interrelation between inflammation mediators and coagulation factors in the early fracture hematoma, and further delineates their influences on hematoma formation during fracture healing, thereby facilitating the advancement of knowledge of fracture hematoma and the development of new approaches to treat and manage bone fracture...
August 21, 2018: Tissue Engineering. Part B, Reviews
Caden Duffy, Cesar Prugue, Rachel Glew, Taryn Smith, Calvin Howell, Gina Choi, Alonzo D Cook
Despite their potential for treating type 1 diabetes (T1D), induced pluripotent stem cells (iPSCs) have not yet been used successfully in the clinic. In this article, advances in iPSC therapies are reviewed and compared with current methods of treating T1D. Encapsulation of iPSCs is being pursued to address such safety concerns as the possibility of immune rejection or teratoma formation, and provide for retrievability. Issues of material selection, cell differentiation, size of islet aggregates, sites of implantation, animal models, and vascularization are also being addressed...
August 20, 2018: Tissue Engineering. Part B, Reviews
Alexandra J Greenberg, Bethany Kinseth Runge, Sarah A Solyntjes, Juliana St Helene-Kraft, Suzanne L Glass, Brian Waletzki, James Herrick, Alan Miller, Michael J Yaszemski, Anthony J Windebank, Huan Wang
A major hurdle in translating biomaterial-based products is moving from the laboratory into first-in-human trials. For many investigators, this is difficult to achieve without industry assistance. A biomaterials facility that follows current Good Manufacturing Practices (cGMP) in an academic medical center would potentially accelerate the process of translating biomedical products to first-in-human trials. This manuscript details the establishment of Mayo Clinic's Biomaterials and Biomolecules cGMP Facility and the challenges encountered in creating a manufacturing facility in an academic medical setting...
August 7, 2018: Tissue Engineering. Part B, Reviews
Alice Cheng, Zvi Schwartz, Adrian Kahn, Xiyu Li, Zhengxing Shao, Muyang Sun, Yingfang Ao, Barbara Boyan, Haifeng Chen
Tissue engineering of bone and cartilage has progressed from simple to sophisticated materials with defined porosity, surface features and the ability to deliver biological factors. To avoid eliciting a foreign body response due to inclusion of allogenic cells, advances in functional scaffold design harness the endogenous ability of the body to regenerate. We review advancements in the surface and structural properties of typical polymeric, ceramic and metallic scaffolds for orthopaedic use. First, we provide an overview of methods and materials, with a focus on additive manufacturing and electrospinning...
August 4, 2018: Tissue Engineering. Part B, Reviews
Ziba Roveimiab, Francis Lin, Judy Anderson
Cell migration is an essential process in which cells move from one location to another with different modes, including mesenchymal, amoeboid or collective movements. Migration occurs during development and in the maintenance of multicellular organisms for purposes of wound healing, tissue regeneration, and immune and pathophysiological responses. Cells in all three types of muscle: cardiac, smooth, and skeletal, are subject to and undergo migration, both general and adapted for tissue-specific needs. Cardiac cell migration is mediated by vascular endothelial growth factor (VEGF) through expression of VEGF receptors; it is not clear how cardiac cells migrate into a region of damage after infarction...
August 3, 2018: Tissue Engineering. Part B, Reviews
Xiaojing Wang, Guowei Wang, Sarah Zingales, Baodong Zhao
Repairing bone defects poses a major orthopedic challenge because current treatments are constrained by the limited regenerative capacity of human bone tissue. Novel therapeutic strategies, such as stem cell therapy and tissue engineering, have the potential to enhance bone healing and regeneration, and hence may improve quality of life for millions of people. However, the ex vivo expansion of stem cells and their in vivo delivery pose technical difficulties that hamper clinical translation and commercial development...
August 3, 2018: Tissue Engineering. Part B, Reviews
Banu Akar, Alexander M Tatara, Alok Sutradhar, Hui-Yi Hsiao, Michael Miller, Ming-Huei Cheng, Antonios G Mikos, Eric M Brey
Reconstruction of large skeletal defects is challenging due to the requirement for large volumes of donor tissue and the often complex surgical procedures. Tissue engineering has the potential to serve as a new source of tissue for bone reconstruction, but current techniques are often limited in regards to the size and complexity of tissue that can be formed. Building tissue using an in vivo bioreactor approach may enable the production of appropriate amounts of specialized tissue, while reducing issues of donor site morbidity and infection...
August 2018: Tissue Engineering. Part B, Reviews
Sarita Kumari, Steven Vermeulen, Ben van der Veer, Aurélie Carlier, Jan de Boer, Deepa Subramanyam
Development of multicellular organisms is a highly orchestrated process, with cells responding to factors and features present in the extracellular milieu. Changes in the surrounding environment help decide the fate of cells at various stages of development. This review highlights recent research that details the effects of mechanical properties of the surrounding environment and extracellular matrix and the underlying molecular mechanisms that regulate the behavior of embryonic stem cells (ESCs). In this study, we review the role of mechanical properties during embryogenesis and discuss the effect of engineered microtopographies on ESC pluripotency...
August 2018: Tissue Engineering. Part B, Reviews
Espen Helgeland, Siddharth Shanbhag, Torbjørn Ostvik Pedersen, Kamal Mustafa, Annika Rosén
Reconstruction of degenerated temporomandibular joint (TMJ) structures remains a clinical challenge. Tissue engineering (TE) is a promising alternative to current treatment options, where the TMJ is either left without functional components, or replaced with autogenous, allogeneic, or synthetic grafts. The objective of this systematic review was to answer the focused question: in experimental animal models, does the implantation of biomaterial scaffolds loaded with cells and/or growth factors (GFs) enhance regeneration of the discal or osteochondral TMJ tissues, compared with scaffolds alone, without cells, or GFs? Following PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analysis) guidelines, electronic databases were searched for relevant controlled preclinical in vivo studies...
August 2018: Tissue Engineering. Part B, Reviews
Evan Davison-Kotler, Vaibhav Sharma, Norbert Venantius Kang, Elena García-Gareta
The complexity of the dermal layer of skin means that damage to this section can result in permanent impairment of function. Partial or total dermal loss is a feature of deep burns and chronic wounds such as pressure sores or diabetic ulcers. The issues posed by traditional skin grafts have led to substantial research being carried out in the fields of tissue engineering and biomaterials science to develop a vast array of alternative skin substitutes. Given the large number of different materials, manufacturing methods, and techniques for implementation described for artificial skin substitutes, many classification systems have been created to simplify their categorization...
August 2018: Tissue Engineering. Part B, Reviews
Xiaofang Chen, Jiaqi Li, Yan Huang, Peng Liu, Yubo Fan
Induced pluripotent stem cells (iPSCs) hold enormous potential as a tool to generate cells for tissue engineering and regenerative medicine. Since the initial report of iPSCs in 2006, many different methods have been developed to enhance the safety and efficiency of this technology. Recent studies indicate that the extracellular signals can promote the production of iPSCs, and even replace the Yamanaka factors. Noticeably, abundant evidences suggest that the insoluble microenvironment, including the culture substrate and neighboring cells, directly regulates the expression of core pluripotency genes and the epigenetic modification of the chromatins, hence, impacts the reprogramming dynamics...
August 2018: Tissue Engineering. Part B, Reviews
Venkat M Ramakrishnan, Nolan L Boyd
A major challenge in tissue engineering is the generation of sufficient volumes of viable tissue for organ transplant. The development of a stable, mature vasculature is required to sustain the metabolic and functional activities of engineered tissues. Adipose stromal vascular fraction (SVF) cells are an easily accessible, heterogeneous cell system comprised of endothelial cells, macrophages, pericytes, and various stem cell populations. Collectively, SVF has been shown to spontaneously form vessel-like networks in vitro and robust, patent, and functional vasculatures in vivo...
August 2018: Tissue Engineering. Part B, Reviews
Valérie Orti, Pierre-Yves Collart-Dutilleul, Sofía Piglionico, Orsolya Pall, Frédéric Cuisinier, Ivan Panayotov
Following the basis of tissue engineering (Cells-Scaffold-Bioactive molecules), regenerative endodontic has emerged as a new concept of dental treatment. Clinical procedures have been proposed by endodontic practitioners willing to promote regenerative therapy. Preserving pulp vitality was a first approach. Later procedures aimed to regenerate a vascularized pulp in necrotic root canals. However, there is still no protocol allowing an effective regeneration of necrotic pulp tissue either in immature or mature teeth...
June 25, 2018: Tissue Engineering. Part B, Reviews
Sara Catarina Nunes da Silva Santos, Ólafur Eysteinn Sigurjonsson, Catarina de Almeida Custódio, João Filipe Colardelle da Luz Mano
Platelet-rich plasma (PRP) and its derivatives have been investigated and applied in regenerative medicine. The use of PRP as a supplement of cell culture media has consistently shown to potentiate stem cell proliferation, migration, and differentiation. In addition, the clinical utility of PRP is supported by evidence that PRP contains high concentrations of growth factors (GFs) and proteins which contribute to the regenerative process. PRP based therapies are cost effective and also benefit from the accessibility and safety of using the patient's own GFs...
June 20, 2018: Tissue Engineering. Part B, Reviews
Mingxue Chen, Weimin Guo, Shuang Gao, Chunxiang Hao, Shi Shen, ZengZeng Zhang, Zehao Wang, Xu Li, Xiaoguang Jing, Xueliang Zhang, Zhiguo Yuan, Mingjie Wang, Yu Zhang, Jiang Peng, Aiyuan Wang, Yu Wang, Sui Xiang, Shuyun Liu, Quanyi Guo
Meniscus injuries are very common in the knee joint. Treating a damaged meniscus continues to be a scientific challenge in sport medicine because of its poor self-healing potential and few clinical therapeutic options. Tissue engineering strategies are very promising solutions for repairing and regenerating a damaged meniscus. Meniscus is exposed to a complex biomechanical microenvironment, and it plays a crucial role in meniscal development, growth, and repairing. Over the past decades, increasing attention has been focused on the use of biomechanical stimulus to enhance biomechanical properties of the engineered meniscus...
June 13, 2018: Tissue Engineering. Part B, Reviews
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