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Tissue Engineering. Part B, Reviews

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https://www.readbyqxmd.com/read/29737237/blood-plasma-derivatives-for-tissue-engineering-and-regenerative-medicine-therapies
#1
Sara Santos, Olafur E Sigurjonsson, Catarina Custodio, João Filipe Colardelle da Luz Mano
Platelet-rich plasma (PRP) and its derivatives have been investigated and applied in regenerative medicine. The use of PRP as a supplement of cell culture media has consistently shown to potentiate stem cell proliferation, migration, and differentiation. In addition, the clinical utility of PRP is supported by evidence that PRP contains high concentrations of growth factors and proteins which contribute to the regenerative process. PRP based therapies are cost effective and also benefit from the accessibility and safety of using the patient's own growth factors...
May 8, 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29724156/pulp-regeneration-concepts-for-non-vital-teeth-from-tissue-engineering-to-clinical-approaches
#2
Valérie Orti, Pierre-Yves Collart-Dutilleul, Sofía Silvia Piglionico, Orsolya Pall, Frédéric Cuisinier, Ivan Vladislavov Panayotov
Following the basis of tissue engineering (Cells - Scaffold - Bioactive molecules), regenerative endodontic has emerged as a new concept of dental treatment. Clinical procedures have been proposed by endodontic practitioners willing to promote regenerative therapy. Preserving pulp vitality was a first approach. Later procedures aimed to regenerate a vascularized pulp in necrotic root canals. However, there is still no protocol allowing an effective regeneration of necrotic pulp tissue either in immature or mature teeth...
May 4, 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29724151/physical-microenvironment-based-inducible-scaffold-for-stem-cell-tenogenesis-and-tendon-regeneration
#3
Hong Zhang, Meng-Fei Liu, Ri-Chun Liu, Wei-Liang Shen, Zi Yin, Xiao Chen
Tendon injuries are common musculoskeletal system disorders, but the tendons have poor regeneration ability. To address this issue, tendon tissue engineering provides potential strategies for future therapeutic treatment. Elements of the physical microenvironment, such as the mechanical force and surface topography, play a vital role in regulating stem cell fate, enhancing the differentiation efficiency of seed cells in tendon tissue engineering. Various inducible scaffolds have been widely explored for tendon regeneration, and scaffold-enhancing modifications have been extensively studied...
May 4, 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29471732/large-animal-models-of-an-in-vivo-bioreactor-for-engineering-vascularized-bone
#4
Banu Akar, Alexander M Tatara, Alok Sutradhar, Hui-Yi Hsiao, Michael Miller, Ming-Huei Cheng, Antonios G Mikos, Eric M Brey
Reconstruction of large skeletal defects is challenging due to the requirement for large volumes of donor tissue and the often complex surgical procedures. Tissue engineering has the potential to serve as a new source of tissue for bone reconstruction, but current techniques are often limited in regards to the size and complexity of tissue that can be formed. Building tissue using an in vivo bioreactor approach may enable the production of appropriate amounts of specialized tissue, while reducing issues of donor site morbidity and infection...
April 12, 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29631491/the-evolution-of-polystyrene-as-a-cell-culture-material
#5
Max J Lerman, Josephine Lembong, Shin Muramoto, Greg Gillen, John P Fisher
Polystyrene (PS) has brought <i>in vitro</i> cell culture from its humble beginnings to the modern era, propelling dozens of research fields along the way. This review discusses the development of the material, fabrication, and treatment approaches to create the culture material. However, native PS surfaces poorly facilitate cell adhesion and growth<i>in vitro</i>. To overcome this, liquid surface deposition, energetic plasma activation, and emerging functionalization methods transform the surface chemistry...
April 10, 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29631489/intraoperative-construct-preparation-a-practical-route-for-cell-based-bone-tissue-engineering
#6
Yang Zhang, Johanna Fa Husch, Jeroen van den Beucken
Stem cell-based bone tissue engineering based on the combination of a scaffold and expanded autologous mesenchymal stem cells (MSCs) represents the conventional, mostly experimental cell-based treatment option for bone defects and fractures. However, the procedure of preparing such constructs, which requires extensive ex vivo manipulation of patient's cells to achieve sufficient stem cells is impractical and not cost-effective compared to standard therapeutic interventions involving autologous bone transplantation...
April 10, 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29455619/shaping-cell-fate-influence-of-topographical-substratum-properties-on-embryonic-stem-cells
#7
Sarita Kumari, Steven Vermeulen, Ben van der Veer, Aurélie Carlier, Jan de Boer, Deepa Subramanyam
Development of multicellular organisms is a highly orchestrated process, with cells responding to factors and features present in the extracellular milieu. Changes in the surrounding environment help decide the fate of cells at various stages of development. This review highlights recent research that details the effects of mechanical properties of the surrounding environment and extracellular matrix and the underlying molecular mechanisms that regulate the behavior of embryonic stem cells (ESCs). In this study, we review the role of mechanical properties during embryogenesis and discuss the effect of engineered microtopographies on ESC pluripotency...
March 27, 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29562835/a-guide-for-using-mechanical-stimulation-to-enhance-tissue-engineered-articular-cartilage-properties
#8
Evelia Y Salinas, Jerry C Hu, Kyriacos A Athanasiou
The use of tissue-engineered articular cartilage (AC) constructs has the potential to become a powerful treatment option for cartilage lesions resulting from trauma or early stages of pathology. Although fundamental tissue-engineering strategies based on the use of scaffolds, cells, and signals have been developed, techniques that lead to biomimetic AC constructs that can be translated to in-vivo use have yet to be fully confirmed. Mechanical stimulation during tissue culture can be an effective strategy to enhance the mechanical, structural, and cellular properties of tissue-engineered constructs toward mimicking those of native AC...
March 21, 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29652595/stem-cells-for-skeletal-muscle-tissue-engineering
#9
Molly N Pantellic, Lisa Marie Larkin
Volumetric muscle loss (VML) is a debilitating condition wherein muscle loss overwhelms the body's normal physiological repair mechanism. VML is particularly common among military service members who have sustained war injuries. Because of the high social and medical cost associated with VML and suboptimal current surgical treatments, there is great interest in developing better VML therapies. Skeletal muscle tissue engineering (SMTE) is a promising alternative to traditional VML surgical treatments that use autogenic tissue grafts, and rather uses isolated stem cells with myogenic potential to generate de novo skeletal muscle tissues to treat VML...
March 14, 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29652594/tissue-engineering-and-regenerative-medicine-2017-a-year-in-review
#10
Kyung Min Park, Young Min Shin, Kyobum Kim, Heungsoo Shin
In 2017, a new paradigm change caused by artificial intelligence and big data analysis resulted in innovation in each field of science and technology, and also significantly influenced progress in tissue engineering and regenerative medicine (TERM). TERM has continued to make technological advances based on interdisciplinary approaches and has contributed to the overall field of biomedical technology including cancer biology, personalized medicine, development biology, and cell-based therapeutics. While researchers are aware that there is still a long way to go until TERM reaches the ultimate goal of patient treatment through clinical translation, the rapid progress in convergence studies led by technological improvements in TERM has been encouraging...
March 13, 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29400140/scaffold-based-temporomandibular-joint-tissue-regeneration-in-experimental-animal-models-a-systematic-review
#11
Espen Helgeland, Siddharth Shanbhag, Torbjørn Ostvik Pedersen, Kamal Mustafa, Annika Rosén
Reconstruction of degenerated temporomandibular joint (TMJ) structures remains a clinical challenge. Tissue engineering (TE) is a promising alternative to current treatment options, where the TMJ is either left without functional components, or replaced with autogenous, allogeneic, or synthetic grafts. The objective of this systematic review was to answer the focused question: in experimental animal models, does the implantation of biomaterial scaffolds loaded with cells and/or growth factors (GFs) enhance regeneration of the discal or osteochondral TMJ tissues, compared with scaffolds alone, without cells, or GFs? Following PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analysis) guidelines, electronic databases were searched for relevant controlled preclinical in vivo studies...
March 8, 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29020880/pulsed-electromagnetic-fields-and-tissue-engineering-of-the-joints
#12
Kenjiro Iwasa, A Hari Reddi
BACKGROUND: Bone and joint formation, maintenance, and regeneration are regulated by both chemical and physical signals. Among the physical signals there is an increasing realization of the role of pulsed electromagnetic fields (PEMF) in the treatment of nonunions of bone fractures. The discovery of the piezoelectric properties of bone by Fukada and Yasuda in 1953 in Japan established the foundation of this field. Pioneering research by Bassett and Brighton and their teams resulted in the approval by the Food and Drug Administration (FDA) of the use of PEMF in the treatment of fracture healing...
April 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28830302/regenerative-medicine-approaches-for-the-treatment-of-pediatric-physeal-injuries
#13
Nichole Shaw, Christopher Erickson, Stephanie J Bryant, Virginia L Ferguson, Melissa D Krebs, Nancy Hadley-Miller, Karin A Payne
The physis, or growth plate, is a cartilaginous region at the end of children's long bones that serves as the primary center for longitudinal growth and characterizes the immature skeleton. Musculoskeletal injury, including fracture, infection, malignancy, or iatrogenic damage, has risk of physeal damage. Physeal injuries account for 30% of pediatric fractures and may result in impaired bone growth. Once damaged, cartilage tissue within the physis is often replaced by unwanted bony tissue, forming a "bony bar" that can lead to complications such as complete growth arrest, angular or rotational deformities, and altered joint mechanics...
April 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29327671/tissue-engineered-heart-valves-a-call-for-mechanistic-studies
#14
Kevin M Blum, Joseph D Drews, Christopher K Breuer
Heart valve disease carries a substantial risk of morbidity and mortality. Outcomes are significantly improved by valve replacement, but currently available mechanical and biological replacement valves are associated with complications of their own. Mechanical valves have a high rate of thromboembolism and require lifelong anticoagulation. Biological prosthetic valves have a much shorter lifespan, and they are prone to tearing and degradation. Both types of valves lack the capacity for growth, making them particularly problematic in pediatric patients...
February 13, 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29336231/a-new-and-universal-classification-system-of-skin-substitutes-inspired-by-factorial-design
#15
Evan Davison-Kotler, Vaibhav Sharma, Norbert Venantius Kang, Elena García-Gareta
The complexity of the dermal layer of skin means that damage to this section can result in permanent impairment of function. Partial or total dermal loss is a feature of deep burns and chronic wounds such as pressure sores or diabetic ulcers. The issues posed by traditional skin grafts have led to substantial research being carried out in the fields of tissue engineering and biomaterials science to develop a vast array of alternative skin substitutes. Given the large number of different materials, manufacturing methods, and techniques for implementation described for artificial skin substitutes, many classification systems have been created to simplify their categorization...
February 12, 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29264951/pushing-the-right-buttons-improving-efficacy-of-therapeutic-dna-vectors
#16
Ara Hacobian, David Hercher
Gene therapy represents a potent therapeutical application for regenerative medicine. So far, viral and nonviral approaches suffer from major drawbacks hindering efficient gene therapeutic applicability: the immunogenicity of viral systems on the one hand, and the low gene transfer efficiency of nonviral systems on the other hand. Therefore, there is a high demand for improvements of therapeutical systems at several levels. This review summarizes different DNA vector modifications to enhance biological efficacy and efficiency of therapeutical vectors, aiming for low toxicity, high specificity, and biological efficacy-the cornerstones for successful translation of gene therapy into the clinic...
February 2, 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29394154/correction-to-increased-paracrine-immunomodulatory-potential-of-mesenchymal-stromal-cells-in-three-dimensional-culture-by-follin-b-juhl-m-cohen-s-pedersen-ae-kastrup-j-and-ekblond-a-tissue-eng-part-b-reviews-2016-22-4-322-329-doi-10-1089-ten-teb-2015-0532
#17
https://www.readbyqxmd.com/read/28825357/multinucleated-giant-cells-good-guys-or-bad-guys
#18
Richard J Miron, Dieter D Bosshardt
Multinucleated giant cells (MNGCs) are a special class of giant cell formed by the fusion of monocytes/macrophages abundantly found in human tissues. While historically their role around certain classes of biomaterials have been directly linked to a foreign body reaction leading to material rejection, recent accumulating evidence has put into question their role around certain classes of bone biomaterials. It was once thought that specifically in bone tissues, all giant cells were considered osteoclasts characterized by their ability to resorb and replace bone grafts with newly formed native bone...
February 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28816104/the-immune-response-to-allogeneic-differentiated-mesenchymal-stem-cells-in-the-context-of-bone-tissue-engineering
#19
Caoimhe H Kiernan, Eppo B Wolvius, Pieter A J Brama, Eric Farrell
The use of allogeneic differentiated mesenchymal stem cells (MSCs) to mediate bone formation may be a potential alternative to the current gold standards of bone repair. Although it is known that undifferentiated MSCs are immunomodulatory and weakly immunogenic, the host immune reaction to differentiated MSCs is less known. Implantation of allogeneic osteogenic or chondrogenically differentiated MSC pellets may be a promising route to induce bone repair via the processes of intramembranous and endochondral ossification...
February 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28726576/recent-developments-in-thiolated-polymeric-hydrogels-for-tissue-engineering-applications
#20
Mani Gajendiran, Jae-Sung Rhee, Kyobum Kim
This review focuses on the recent strategy in the preparation of thiolated polymers and fabrication of their hydrogel matrices. The mechanism involved in the synthesis of thiolated polymers and fabrication of thiolated polymer hydrogels is exemplified with suitable schematic representations reported in the recent literature. The 2-iminothiolane namely "Traut's reagent" has been widely used for effectively thiolating the natural polymers such as collagen and gelatin, which contain free amino group in their backbone...
February 2018: Tissue Engineering. Part B, Reviews
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