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Tissue Engineering. Part B, Reviews

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https://www.readbyqxmd.com/read/28316259/the-adipose-stromal-vascular-fraction-as-a-complex-cellular-source-for-tissue-engineering-applications
#1
Venkat M Ramakrishnan, Nolan L Boyd
A major challenge in tissue engineering is the generation of sufficient volumes of viable tissue for organ transplant. The development of a stable, mature vasculature is required to sustain the metabolic and functional activities of engineered tissues. Adipose stromal vascular fraction (SVF) cells are an easily accessible, heterogeneous cell system comprised of endothelial cells, macrophages, pericytes, and various stem cell populations. Collectively, SVF has been shown to spontaneously form vessel-like networks in vitro and robust, patent, and functional vasculatures in vivo...
April 13, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28401807/biophysical-stimulation-for-engineering-functional-skeletal-muscle
#2
Sarah Somers, Alexander Spector, Douglas DiGirolamo, Warren L Grayson
Tissue engineering is a promising therapeutic strategy to regenerate skeletal muscle. However, ex vivo cultivation methods typically result in a low differentiation efficiency of stem cells as well as grafts that resemble the native tissues morphologically, but lack contractile function. The application of biomimetic tensile strain provides a potent stimulus for enhancing myogenic differentiation and engineering functional skeletal muscle grafts. We reviewed integrin-dependent mechanisms that potentially link mechanotransduction pathways to the upregulation of myogenic genes...
April 12, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28376649/tuning-cell-and-tissue-development-by-combining-multiple-mechanical-signals
#3
Ravi Sinha, Nico Verdonschot, Bart Koopman, Jeroen Rouwkema
Mechanical signals offer a promising way to control cell and tissue development. It has been established that cells constantly probe their mechanical microenvironment and employ force feedback mechanisms to modify themselves and when possible, their environment, to reach a homeostatic state. Thus a correct mechanical microenvironment (external forces and mechanical properties and shapes of cellular surroundings) is necessary for the proper functioning of cells. In vitro or in the case of non-biological implants in vivo, where cells are in an artificial environment, adding the adequate mechanical signals can therefore enable the cells to function normally as in vivo...
April 4, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28372518/collagen-membrane-and-immune-response-in-guided-bone-regeneration-recent-progress-and-perspectives
#4
Chenyu Chu, Jia Deng, Xianchang Sun, Yili Qu, Yi Man
Collagen is one of the important components of collagen membranes as well as the extracellular matrix (ECM). Most previous studies have focused on combining collagen membranes with various cross-linking agents, grafting materials, and cytokines to enhance their mechanical properties and bioactivities. Moreover, collagen membranes are often designed to minimize foreign body reactions involving macrophages. However, macrophages were recently found to play a pivotal role during bone regeneration based on their polarization into both pro-inflammatory and anti-inflammatory phenotypes...
April 3, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28372485/a-review-of-cell-based-strategies-for-soft-tissue-reconstruction
#5
Elizabeth A Brett, Natalie Chung, Tripp Leavitt, Arash Momeni, Michael T Longaker, Derrick C Wan
Soft tissue reconstruction to restore volume to damaged or deficient tissue beneath the skin remains a challenging endeavor. Current techniques are centered around autologous fat transfer, or the use of synthetic substitutes, however a great deal of scientific inquiry has been made into both the molecular mechanisms involved in, as well as limitations of, de novo adipogenesis, i.e. the formation of new adipose tissue from precursor cells. To best comprehend these mechanisms, an understanding of defined markers for adipogenic differentiation, as well as knowledge of both commercially available and primary cell lines that enable in vitro and in vivo studies is necessary...
April 3, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28103751/three-dimensional-bioprinting-toward-the-era-of-manufacturing-human-organs-as-spare-parts-for-healthcare-and-medicine
#6
Tanveer Ahmad Mir, Makoto Nakamura
Three-dimensional (3D) printing technology has been used in industrial worlds for decades. Three-dimensional bioprinting has recently received an increasing attention across the globe among researchers, academicians, students, and even the ordinary people. This emerging technique has a great potential to engineer highly organized functional bioconstructs with complex geometries and tailored components for engineering bioartificial tissues/organs for widespread applications, including transplantation, therapeutic investigation, drug development, bioassay, and disease modeling...
March 21, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28166711/biomaterial-guided-gene-delivery-for-musculoskeletal-tissue-repair
#7
Justin L Madrigal, Roberta Stilhano, Eduardo A Silva
Gene therapy is a promising strategy for musculoskeletal tissue repair and regeneration where local and sustained expression of proteins and/or therapeutic nucleic acids can be achieved. However, the musculoskeletal tissues present unique engineering and biological challenges as recipients of genetic vectors. Targeting specific cell populations, regulating expression in vivo, and overcoming the harsh environment of damaged tissue accompany the general concerns of safety and efficacy common to all applications of gene therapy...
March 10, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28169595/tissue-derived-extracellular-matrix-bioscaffolds-emerging-applications-in-cartilage-and-meniscus-repair
#8
Farrah A Monibi, James L Cook
Musculoskeletal injuries are a common problem in orthopedic practice. Given the long-term consequences of unaddressed cartilage and meniscal pathology, a number of treatments have been attempted to stimulate repair or to replace the injured tissue. Despite advances in orthopedic surgery, effective treatments for cartilage and meniscus injuries remain a significant clinical challenge. Tissue engineering is a developing field that aims to regenerate injured tissues with a combination of cells, scaffolds, and signals...
March 7, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28067115/macroporous-hydrogel-scaffolds-for-three-dimensional-cell-culture-and-tissue-engineering
#9
Changjiang Fan, Dong-An Wang
Hydrogels have been promising candidate scaffolds for cell delivery and tissue engineering due to their tissue-like physical properties and capability for homogeneous cell loading. However, the encapsulated cells are generally entrapped and constrained in the submicron- or nanosized gel networks, seriously limiting cell growth and tissue formation. Meanwhile, the spatially confined settlement inhibits attachment and spreading of anchorage-dependent cells, leading to their apoptosis. In recent years, macroporous hydrogels have attracted increasing attention in use as cell delivery vehicles and tissue engineering scaffolds...
February 3, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28034338/bioengineering-strategies-to-treat-female-infertility
#10
Che-Ying Kuo, Hannah Baker, Melissa H Fries, James J Yoo, Peter C W Kim, John P Fisher
Bioengineering strategies have demonstrated enormous potential to treat female infertility as a result of chemotherapy, uterine injuries, fallopian tube occlusion, massive intrauterine adhesions, congenital uterine malformations, and hysterectomy. These strategies can be classified into two broad categories as follows: (i) Transplantation of fresh or cryopreserved organs into the host and (ii) tissue engineering approaches that utilize a combination of cells, growth factors, and biomaterials that leverages the body's inherent ability to regenerate/repair reproductive organs...
February 3, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28142381/questions-and-challenges-in-the-development-of-mesenchymal-stromal-stem-cell-based-therapies-in-veterinary-medicine
#11
Lax Devireddy, Lynne Boxer, Michael Myers, Mark Skasko, Rudell Screven
he therapeutic potential of stem cells has fascinated those interested in treating diseases in both human and animal subjects. Although the exact mechanism of action and the definitive effectiveness of stem cell therapies remain unclear, animal owner perceptions and a desire for improved treatment options have fueled the interest of clinicians and stakeholders. Standards do not yet exist to define the critical attributes of mesenchymal stem cell (MSC)-based products derived from veterinary species such as the dog, cat, and horse...
January 31, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27824295/injectable-pore-forming-hydrogel-scaffolds-for-complex-wound-tissue-engineering-designing-and-controlling-their-porosity-and-mechanical-properties
#12
Robert M T Staruch, Graeme E Glass, Rory Rickard, Shehan P Hettiaratchy, Peter E M Butler
Traumatic soft tissue wounds present a significant reconstructive challenge. The adoption of closed-circuit negative pressure wound therapy (NPWT) has enabled surgeons to temporize these wounds before reconstruction. Such systems use porous synthetic foam scaffolds as wound fillers at the interface between the negative pressure system and the wound bed. The idea of using a bespoke porous biomaterial that enhances wound healing, as filler for an NPWT system, is attractive as it circumvents concerns regarding reconstructive delay and the need for dressing changes that are features of the current systems...
April 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27824290/design-and-use-of-chimeric-proteins-containing-a-collagen-binding-domain-for-wound-healing-and-bone-regeneration
#13
Cyril Addi, Frederic Murschel, Gregory De Crescenzo
Collagen-based biomaterials are widely used in the field of tissue engineering; they can be loaded with biomolecules such as growth factors (GFs) to modulate the biological response of the host and thus improve its potential for regeneration. Recombinant chimeric GFs fused to a collagen-binding domain (CBD) have been reported to improve their bioavailability and the host response, especially when combined with an appropriate collagen-based biomaterial. This review first provides an extensive description of the various CBDs that have been fused to proteins, with a focus on the need for accurate characterization of their interaction with collagen...
April 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27771996/how-regenerative-medicine-stakeholders-adapt-to-ever-changing-technology-and-regulatory-challenges-snapshots-from-the-world-termis-industry-symposium-september-10-2015-boston
#14
Yves Bayon, Mark Van Dyke, Robert Buelher, Ross Tubo, Tim Bertram, Bernard Malfroy-Camine, Michelle Rathman, Vincent Ronfard
Regenerative medicine (RM) is a fascinating area of research and innovation. The huge potential of the field has been fairly underexploited so far. Both TERMIS-AM and TERMIS-EU Industry Committees are committed to mentoring and training young entrepreneurs for more successful commercial translation of upstream research. With this objective in mind, the two entities jointly organized an industry symposium during the past TERMIS World Congress (Boston, September 8-11, 2015) and invited senior managers of the RM industry for lectures and panel discussions...
April 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27763207/potential-use-of-antiapoptotic-proteins-and-noncoding-rnas-for-efficient-in-vitro-follicular-maturation-and-ovarian-bioengineering
#15
Yoon Young Kim, Amin Tamadon, Seung-Yup Ku
In vitro culture of ovarian follicles is a promising bioengineering technique for preserving fecundity in reproductive-aged female by providing fertilizable oocytes. Successful clinical application should be preceded by developing the protocols that can efficiently overcome follicular cell apoptosis since the apoptosis is a critical phenomenon in in vivo folliculogenesis and in in vitro follicular maturation. Numerous prosurvival and antiapoptotic molecules, including follicular developmental regulators, have been reported to be involved in the intraovarian apoptosis...
April 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27762892/evaluating-the-past-present-and-future-of-regenerative-medicine-a-global-view
#16
Vincent Ronfard, Alain A Vertès, Michael H May, Anne Dupraz, Mark E van Dyke, Yves Bayon
"Evaluating the Past and Present of Regenerative Medicine (RM)" was the first part of an Industry Symposium dedicated to the subject during the 2015 TERMIS World Congress in Boston. This working session presented a critical review of the current RM landscape in Europe and North America with possible projections for the future. Interestingly, the RM development cycle seems to obey the Gartner hype cycle, now at the enlightenment phase, after past exaggerated expectations and discouragements, as suggested by increasing numbers of clinical trials and recent market approvals of RM solutions in both Europe (Glybera and Holoclar(®) from Chiesi Pharma and Strimvelis(®) from GSK) and Japan (Remestemcel-L from Mesoblast(®))...
April 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27758156/endochondral-priming-a-developmental-engineering-strategy-for-bone-tissue-regeneration
#17
Fiona E Freeman, Laoise M McNamara
Tissue engineering and regenerative medicine have significant potential to treat bone pathologies by exploiting the capacity for bone progenitors to grow and produce tissue constituents under specific biochemical and physical conditions. However, conventional tissue engineering approaches, which combine stem cells with biomaterial scaffolds, are limited as the constructs often degrade, due to a lack of vascularization, and lack the mechanical integrity to fulfill load bearing functions, and as such are not yet widely used for clinical treatment of large bone defects...
April 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27758155/an-investigation-of-topics-and-trends-of-tracheal-replacement-studies-using-co-occurrence-analysis
#18
Fariba Ghorbani, Mansoureh Feizabadi, Roya Farzanegan, Esmaeil Vaziri, Saeed Samani, Seyedamirmohammad Lajevardi, Lida Moradi, Mohammad Behgam Shadmehr
This study evaluated tracheal regeneration studies using scientometric and co-occurrence analysis to identify the most important topics and assess their trends over time. To provide the adequate search options, PubMed, Scopus, and Web of Science (WOS) were used to cover various categories such as keywords, countries, organizations, and authors. Search results were obtained by employing Bibexcel. Co-occurrence analysis was applied to evaluate the publications. Finally, scientific maps, author's network, and country contributions were depicted using VOSviewer and NetDraw...
April 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27733094/cell-cotransplantation-strategies-for-vascularized-craniofacial-bone-tissue-engineering-a-systematic-review-and-meta-analysis-of-preclinical-in-vivo-studies
#19
Siddharth Shanbhag, Nikolaos Pandis, Kamal Mustafa, Jens R Nyengaard, Andreas Stavropoulos
The regenerative potential of tissue-engineered bone constructs may be enhanced by in vitro coculture and in vivo cotransplantation of vasculogenic and osteogenic (progenitor) cells. The objective of this study was to systematically review the literature to answer the focused question: In animal models, does cotransplantation of osteogenic and vasculogenic cells enhance bone regeneration in craniofacial defects, compared with solely osteogenic cell-seeded constructs? Following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, electronic databases were searched for controlled animal studies reporting cotransplantation of endothelial cells (ECs) with mesenchymal stem cells (MSCs) or osteoblasts in craniofacial critical size defect (CSD) models...
April 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28140828/correction-re-tissue-engineering-part-b-2016-22-5-341-357
#20
(no author information available yet)
No abstract text is available yet for this article.
February 2017: Tissue Engineering. Part B, Reviews
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