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Tissue Engineering. Part B, Reviews

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https://www.readbyqxmd.com/read/28092213/cellular-and-molecular-factors-influencing-tendon-repair
#1
Sushmitha Durgam, Matthew Stewart
Tendons are complex, hierarchically organized connective tissues that transmit tensile forces between muscles and tendons. Tendon injuries are among the most common orthopedic problems with long-term disability as a frequent consequence due to prolonged healing time. Further, the repair tissue is of inferior quality, predisposing patients to high rates of recurrence following initial injury. Co-ordinated cellular processes and biological factors under the influence of mechanical loading are involved in tendon healing and our understanding of these events lags behind other musculoskeletal tissues...
January 16, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28084902/the-rotator-cuff-organ-integrating-developmental-biology-tissue-engineering-and-surgical-considerations-to-treat-chronic-massive-rotator-cuff-tears
#2
Benjamin B Rothrauff, Thierry Pauyo, Richard E Debski, Mark W Rodosky, Rocky Tuan, Volker Musahl
The torn rotator cuff remains a persistent orthopaedic challenge, with poor outcomes disproportionately associated with chronic, massive tears. Degenerative changes in the tissues that comprise the rotator cuff organ, including muscle, tendon, and bone, contribute to the poor healing capacity of chronic tears, resulting in poor function and an increased risk for repair failure. Tissue engineering strategies to augment rotator cuff repair have been developed in an effort to improve rotator cuff healing and have focused on three principal aims: (1) immediate mechanical augmentation of the surgical repair, (2) regeneration of native enthesis structure, and (3) restoration of muscle quality and contractility...
January 13, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27998240/superparamagnetic-iron-oxide-nanoparticles-in-musculoskeletal-biology
#3
Shama R Iyer, Su Xu, Joseph P Stains, Craig H Bennett, Richard M Lovering
The use of platelet-rich plasma and mesenchymal stem cells has garnered much attention in orthopedic medicine, focusing on the biological aspects of cell function. However, shortly after systemic delivery, or even a local injection, few of the transplanted stem cells or platelets remain at the target site. Improvement in delivery, and the ability to track and monitor injected cells, would greatly improve clinical translation. Nanoparticles can effectively and quickly label most cells in vitro, and evidence to date suggests such labeling does not compromise the proliferation or differentiation of cells...
January 11, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27981886/additive-manufacturing-of-vascular-grafts-and-vascularized-tissue-constructs
#4
Laura Elomaa, Yunzhi Peter Yang
There is a great need for engineered vascular grafts among patients with cardiovascular diseases who are in need of bypass therapy and lack autologous healthy blood vessels. In addition, because of the severe worldwide shortage of organ donors, there is an increasing need for engineered vascularized tissue constructs as an alternative to organ transplants. Additive manufacturing (AM) offers great advantages and flexibility of fabrication of cell-laden, multimaterial, and anatomically shaped vascular grafts and vascularized tissue constructs...
January 10, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28068870/induced-remodeling-of-porcine-tendons-to-human-anterior-cruciate-ligaments-by-%C3%AE-gal-epitope-removal-and-partial-crosslinking
#5
Kevin Robert Stone, Ann Walgenbach, Uri Galili
This review describes a novel method developed for processing porcine tendon and other ligament implants which enables in situ remodeling into autologous ligaments in humans. The method differs from methods using extracellular matrices (ECM) which provide post-operative ortho-biologic support (i.e. augmentation grafts) for healing of injured ligaments, in that the porcine bone-patellar-tendon-bone itself serves as the graft replacing ruptured anterior cruciate ligament (ACL). The method allows for gradual remodeling of porcine tendon into autologous human ACL while maintaining the biomechanical integrity...
January 9, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28067115/macro-porous-hydrogel-scaffolds-for-3-d-cell-culture-and-tissue-engineering
#6
Changjiang Fan, Dong-An Wang
Hydrogels have been promising candidate scaffolds for cell delivery and tissue engineering due to their tissue-like physical properties and capability for homogeneous cell loading. However, the encapsulated cells are generally entrapped and constrained in the submicron- or nano-sized gel networks, seriously limiting cell growth and tissue formation. Meanwhile, the spatially-confined settlement inhibits attachment and spreading of anchorage dependent cells, leading to their apoptosis. In recent years, macro-porous hydrogels have attracted increasing attention in use as cell delivery vehicles and tissue engineering scaffolds...
January 8, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28034338/bioengineering-strategies-to-treat-female-infertility
#7
Che-Ying Kuo, Hannah B Baker, Melissa H Fries, James J Yoo, Peter Cw Kim, John P Fisher
Bioengineering strategies have demonstrated enormous potential to treat female infertility as a result of chemotherapy, uterine injuries, fallopian tube occlusion, massive intrauterine adhesions, congenital uterine malformations and hysterectomy. These strategies can be classified into two broad categories: 1) Transplantation of fresh or cryopreserved organs into the host; and 2) tissue engineering approaches that utilize a combination of cells, growth factors and biomaterials that leverages the body's inherent ability to regenerate/repair reproductive organs...
December 30, 2016: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27875945/three-dimensional-printing-articular-cartilage-recapitulating-the-complexity-of-native-tissue
#8
Ting Guo, Josephine Lembong, Lijie Grace Zhang, John P Fisher
In the past few decades, the field of tissue engineering combined with rapid prototyping (RP) techniques has been successful in creating biological substitutes that mimic tissues. Its applications in regenerative medicine have drawn efforts in research from various scientific fields, diagnostics, and clinical translation to therapies. While some areas of therapeutics are well developed, such as skin replacement, many others such as cartilage repair can still greatly benefit from tissue engineering and RP due to the low success and/or inefficiency of current existing, often surgical treatments...
December 27, 2016: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27846781/osteoblast-differentiation-and-bone-matrix-formation-in-vivo-and-in-vitro
#9
Harry C Blair, Quitterie C Larrouture, Yanan Li, Hang Lin, Donna Beer-Stoltz, Li Liu, Rocky S Tuan, Lisa J Robinson, Paul H Schlesinger, Deborah J Nelson
We review the characteristics of osteoblast differentiation and bone matrix synthesis. Bone in air breathing vertebrates is a specialized tissue that developmentally replaces simpler solid tissues, usually cartilage. Bone is a living organ bounded by a layer of osteoblasts that, because of transport and compartmentalization requirements, produce bone matrix exclusively as an organized tight epithelium. With matrix growth, osteoblasts are reorganized and incorporated into the matrix as living cells, osteocytes, which communicate with each other and surface epithelium by cell processes within canaliculi in the matrix...
December 27, 2016: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27824295/injectable-pore-forming-hydrogel-scaffolds-for-complex-wound-tissue-engineering-designing-and-controlling-their-porosity-and-mechanical-properties
#10
Robert M T Staruch, Graeme E Glass, Rory Rickard, Shehan P Hettiaratchy, Peter E M Butler
Traumatic soft tissue wounds present a significant reconstructive challenge. The adoption of closed-circuit negative pressure wound therapy (NPWT) has enabled surgeons to temporize these wounds before reconstruction. Such systems use porous synthetic foam scaffolds as wound fillers at the interface between the negative pressure system and the wound bed. The idea of using a bespoke porous biomaterial that enhances wound healing, as filler for an NPWT system, is attractive as it circumvents concerns regarding reconstructive delay and the need for dressing changes that are features of the current systems...
December 26, 2016: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27981888/diabetes-mellitus-and-bone-regeneration-a-systematic-review-and-meta-analysis-of-animal-studies
#11
Winston Adam Camargo, Rob de Vries, Judith van Luijk, Ewald M Bronkhorst, Jan Willem M Hoekstra, Jeroen van den Beucken, John A Jansen
Background The regeneration of bone defects resulting from trauma, resection of tumours, infection or congenital disease is a challenge, and bone grafts are utilized in a wide array of clinical settings to augment bone repair and regeneration. Diabetes Mellitus is a chronic metabolic disease, which affects 8.3% of the world population, summing approximately 387 million individuals. The consequences of the disease, e.g. hyperglycaemia, have been linked to poor bone quality and reduced capacity to form bone, influencing bone healing...
December 16, 2016: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27824290/design-and-use-of-chimeric-proteins-containing-a-collagen-binding-domain-for-wound-healing-and-bone-regeneration
#12
Cyril Addi, Frederic Murschel, Gregory De Crescenzo
Collagen-based biomaterials are widely used in the field of tissue engineering; they can be loaded with biomolecules such as growth factors (GFs) to modulate the biological response of the host and thus improve its potential for regeneration. Recombinant chimeric GFs fused to a collagen-binding domain (CBD) have been reported to improve their bioavailability and the host response, especially when combined with an appropriate collagen-based biomaterial. This review first provides an extensive description of the various CBDs that have been fused to proteins, with a focus on the need for accurate characterization of their interaction with collagen...
December 12, 2016: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27917703/principles-of-the-kenzan-method-for-robotic-cell-spheroid-based-3d-bioprinting
#13
Nicanor I Moldovan, Narutoshi Hibino, Koichi Nakayama
Bioprinting is a technology with the prospect to change the way many diseases are treated, by replacing the damaged tissues with live, de novo created bio-similar constructs. However, after more than a decade of incubation and many proofs-of-concept, the field is still in its infancy. The current stagnation is the consequence of its early success: the first bioprinters, and most of those which followed, were modified versions of the 3D printers used in additive manufacturing, redesigned for layer-by-layer dispersion of biomaterials...
December 4, 2016: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27912680/biomimetic-approaches-for-bone-tissue-engineering
#14
Johnathan Ng, Kara Spiller, Jonathan Bernhard, Gordana Vunjak-Novakovic
Although autologous bone grafts are considered a gold standard for the treatment of bone defects, they are limited by donor site morbidities and geometric requirements. Tissue engineering can overcome such limitations by creating fully viable biological bone grafts. We review here the use of native bone matrix, autologous mesenchymal cells and perfusion bioreactor systems as a tissue-engineering paradigm to grow bone in vitro. We also discuss emergent vascularization strategies to promote graft survival in vivo, and the role of inflammation in bone repair...
December 2, 2016: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27809709/systematic-review-to-compare-urothelium-differentiation-with-urethral-epithelium-differentiation-in-fetal-development-as-a-basis-for-tissue-engineering-of-the-male-urethra
#15
Petra de Graaf, E Martine van der Linde, Peter F W M Rosier, Ander Izeta, Karl-Dietrich Sievert, J L H Ruud Bosch, Laetitia M O de Kort
BACKGROUND: Tissue-engineered (TE) urethra is desirable in men with urethral disease (stricture or hypospadias) and shortage of local tissue. Although ideally a TE graft would contain urethral epithelium cells, currently, bladder epithelium (urothelium) is widely used, but morphologically different. Understanding the differences and similarities of urothelium and urethral epithelium could help design a protocol for in vitro generation of urethral epithelium to be used in TE grafts for the urethra...
December 2, 2016: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27758156/endochondral-priming-a-developmental-engineering-strategy-for-bone-tissue-regeneration
#16
Fiona E Freeman, Laoise M McNamara
Tissue engineering and regenerative medicine have significant potential to treat bone pathologies by exploiting the capacity for bone progenitors to grow and produce tissue constituents under specific biochemical and physical conditions. However, conventional tissue engineering approaches, which combine stem cells with biomaterial scaffolds, are limited as the constructs often degrade, due to a lack of vascularization, and lack the mechanical integrity to fulfill load bearing functions, and as such are not yet widely used for clinical treatment of large bone defects...
November 22, 2016: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27758155/an-investigation-of-topics-and-trends-of-tracheal-replacement-studies-using-co-occurrence-analysis
#17
Fariba Ghorbani, Mansoureh Feizabadi, Roya Farzanegan, Esmaeil Vaziri, Saeed Samani, Seyedamirmohammad Lajevardi, Lida Moradi, Mohammad Behgam Shadmehr
This study evaluated tracheal regeneration studies using scientometric and co-occurrence analysis to identify the most important topics and assess their trends over time. To provide the adequate search options, PubMed, Scopus, and Web of Science (WOS) were used to cover various categories such as keywords, countries, organizations, and authors. Search results were obtained by employing Bibexcel. Co-occurrence analysis was applied to evaluate the publications. Finally, scientific maps, author's network, and country contributions were depicted using VOSviewer and NetDraw...
November 22, 2016: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27771996/how-regenerative-medicine-stakeholders-adapt-to-ever-changing-technology-and-regulatory-challenges-snapshots-from-the-world-termis-industry-symposium-september-10-2015-boston
#18
Yves Bayon, Mark Van Dyke, Robert Buelher, Ross Tubo, Tim Bertram, Bernard Malfroy-Camine, Michelle Rathman, Vincent Ronfard
Regenerative medicine (RM) is a fascinating area of research and innovation. The huge potential of the field has been fairly underexploited so far. Both TERMIS-AM and TERMIS-EU Industry Committees are committed to mentoring and training young entrepreneurs for more successful commercial translation of upstream research. With this objective in mind, the two entities jointly organized an industry symposium during the past TERMIS World Congress (Boston, September 8-11, 2015) and invited senior managers of the RM industry for lectures and panel discussions...
November 21, 2016: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27762892/evaluating-the-past-present-and-future-of-regenerative-medicine-a-global-view
#19
Vincent Ronfard, Alain A Vertès, Michael H May, Anne Dupraz, Mark E van Dyke, Yves Bayon
"Evaluating the Past and Present of Regenerative Medicine (RM)" was the first part of an Industry Symposium dedicated to the subject during the 2015 TERMIS World Congress in Boston. This working session presented a critical review of the current RM landscape in Europe and North America with possible projections for the future. Interestingly, the RM development cycle seems to obey the Gartner hype cycle, now at the enlightenment phase, after past exaggerated expectations and discouragements, as suggested by increasing numbers of clinical trials and recent market approvals of RM solutions in both Europe (Glybera and Holoclar(®) from Chiesi Pharma and Strimvelis(®) from GSK) and Japan (Remestemcel-L from Mesoblast(®))...
November 21, 2016: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27470313/the-value-of-systematic-reviews-in-estimating-the-cost-and-barriers-to-translation-in-tissue-engineering
#20
Margot A Cousin, Alexandra J Greenberg, Tyler H Koep, Diana Angius, Michael J Yaszemski, Robert J Spinner, Anthony J Windebank
Little quantitative data exist concerning barriers that impede translation from bench to bedside. We systematically reviewed synthetic or biosynthetic polymer nerve scaffolds for peripheral nerve repair to study a defined research area that is beyond the discovery phase and has potential for clinical application. Using electronic and manual search methods, we identified published English language articles, where scaffolds were tested in preclinical animal models. A systematic review of these 416 reports estimated all costs related to the use of animals, surgery, and evaluation methods...
December 2016: Tissue Engineering. Part B, Reviews
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