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Tissue Engineering. Part B, Reviews

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https://www.readbyqxmd.com/read/28514935/mesenchymal-stem-cell-based-cartilage-regeneration-approach-and-cell-senescence-can-we-manipulate-cell-aging-and-function
#1
Marta Anna Szychlinska, Martin James Stoddart, Ugo D'Amora, Luigi Ambrosio, Mauro Alini, Giuseppe Musumeci
Aging is the most prominent risk factor triggering several degenerative diseases, such as Osteoarthritis (OA). Due to its poor self-healing capacity, once injured cartilage needs to be re-established. This process mighmight be approached bythrough resorting to cell-based therapies and/or tissue engineering. Human mesenchymal stem cells (hMSC) represent a promising approach due to their chondrogenic differentiation potential. Presently, in vitro chondrogenic differentiation of MSCs is limited by two main reasons: Aging aging of MSCs, which determines the loss of cell proliferative and differentiationed capacity and MSC-derived chondrocyte hypertrophic differentiation, which limits the use of these cells in cartilage tissue regeneration approach...
May 17, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28514897/biomaterials-and-bioactive-agents-in-spinal-fusion
#2
Rui M Duarte, Pedro Varanda, Rui L Reis, Ana Rita C Duarte, Jorge Correia-Pinto
Management of degenerative spine pathologies frequently leads to the need for spinal fusion, where bone growth is induced towards stabilization of the interventioned spine. Autologous bone graft (ABG) remains the gold standard inducer, while new bone graft substitutes attempt to achieve effective de novo bone formation and solid fusion. Limited fusion outcomes have driven motivation for more sophisticated and multidisciplinary solutions, involving new biomaterials and/or biologics, through innovative delivery platforms...
May 17, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28490258/trophic-effects-of-mesenchymal-stem-cells-in-tissue-regeneration
#3
Yao Fu, Lisanne Karbaat, Ling Wu, Jeroen C H Leijten, Sanne Both, Marcel Karperien
Mesenchymal stem cells (MSCs) are considered to hold great therapeutic value for cell-based therapy and for tissue regeneration in particular. Recent evidence indicates that the main underlying mechanism for MSCs' beneficial effects in tissue regeneration is based on their capability to produce a large variety of bioactive trophic factors that stimulate neighboring parenchymal cells to start repairing damaged tissues. These new findings could potential replace the classical paradigm of MSC differentiation and cell replacement...
May 10, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28474536/comments-on-an-overview-of-protocols-for-the-neural-induction-of-dental-and-oral-stem-cells-in-vitro-article-in-tissue-engineering-part-b-heng-et-al-february-2016-doi-10-1089-ten-teb-2015-0488
#4
Orsolya Pall, Bela Varga Varga, Pierre-Yves Collart-Dutilleul, Csilla Gergely, Frédéric Cuisinier
We read with interest the review of Heng et al.(2016). The article summarizes a wide range of protocols about the in vitro neurodifferentiation of different dental and oral stem cells. Our research group is also interested in the study of neurogenic potential of dental pulp stem cells, so we were pleased to find such a detailed and comprehensive review about this topic. Unfortunately when reading carefully the article, we observed numerous errors regarding for example the quantity of the products in several protocols...
May 5, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28372518/collagen-membrane-and-immune-response-in-guided-bone-regeneration-recent-progress-and-perspectives
#5
Chenyu Chu, Jia Deng, Xianchang Sun, Yili Qu, Yi Man
Collagen is one of the important components of collagen membranes as well as the extracellular matrix (ECM). Most previous studies have focused on combining collagen membranes with various cross-linking agents, grafting materials, and cytokines to enhance their mechanical properties and bioactivities. Moreover, collagen membranes are often designed to minimize foreign body reactions involving macrophages. However, macrophages were recently found to play a pivotal role during bone regeneration based on their polarization into both proinflammatory and anti-inflammatory phenotypes...
May 5, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28437235/breast-augmentation-and-reconstruction-from-a-regenerative-medicine-point-of-view-state-of-the-art-and-future-perspectives
#6
Luke E Visscher, Matthew Cheng, Mohit Chhaya, Madeline L Hintz, Jan-Thorsten Schantz, Phong Tran, Owen Ung, Clement Wong, Dietmar W Hutmacher
Breast reconstruction and augmentation are very common procedures, yet the prevailing current methods utilize silicone implants that may have significant local complications requiring reoperation. Lipofillling is increasingly used to contour and is considered safe, however, its utility is limited by significant volume loss. A new approach could offer an alternative and increase the scope of patient choice. A small number of teams around the world are investigating a breast tissue engineering (TE) paradigm. Conventional breast TE concepts are based on seeding a scaffold with the patients' own stem cells...
May 4, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28376649/tuning-cell-and-tissue-development-by-combining-multiple-mechanical-signals
#7
Ravi Sinha, Nico Verdonschot, Bart Koopman, Jeroen Rouwkema
Mechanical signals offer a promising way to control cell and tissue development. It has been established that cells constantly probe their mechanical microenvironment and employ force feedback mechanisms to modify themselves and when possible, their environment, to reach a homeostatic state. Thus, a correct mechanical microenvironment (external forces and mechanical properties and shapes of cellular surroundings) is necessary for the proper functioning of cells. In vitro or in the case of nonbiological implants in vivo, where cells are in an artificial environment, addition of the adequate mechanical signals can, therefore, enable the cells to function normally as in vivo...
May 3, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28463576/advances-in-application-of-mechanical-stimuli-in-bioreactors-for-cartilage-tissue-engineering
#8
Ke Li, Chunqiu Zhang, Lulu Qiu, Lilan Gao, Xizheng Zhang
Articular cartilage is the weight-bearing tissue in diarthroses. It lacks the capacity for self-healing once there are injuries or diseases due to its avascularity. With the development of tissue engineering, repairing cartilage defects through the transplantation of engineered cartilage that closely matches the properties of native cartilage has become a new option for curing cartilage diseases. The main hurdle for clinical application of engineered cartilage is how to develop functional cartilage constructs for mass production in a credible way...
May 2, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28457175/tissue-engineering-and-regenerative-medicine-new-trends-and-directions-a-year-in-review
#9
Manuela E Gomes, Márcia T Rodrigues, Rui M A Domingues, Rui L Reis
Tissue Engineering (TE) is continuously evolving assimilating inputs from adjacent scientific areas and their technological advances, including nanotechnology developments that have been spawning the range of available options for the precise manipulation and control of cells and cellular environments. Simultaneously, with the maturation of the field, TE is having a growing and marked impact in other fields, such as cancer and other diseases research, enabling tri-dimensional (3D) tumor/tissue models of increased complexity that more closely resemble living tissue dynamics, playing a decisive role in the development of new and improved therapies...
April 29, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28316259/the-adipose-stromal-vascular-fraction-as-a-complex-cellular-source-for-tissue-engineering-applications
#10
Venkat M Ramakrishnan, Nolan L Boyd
A major challenge in tissue engineering is the generation of sufficient volumes of viable tissue for organ transplant. The development of a stable, mature vasculature is required to sustain the metabolic and functional activities of engineered tissues. Adipose stromal vascular fraction (SVF) cells are an easily accessible, heterogeneous cell system comprised of endothelial cells, macrophages, pericytes, and various stem cell populations. Collectively, SVF has been shown to spontaneously form vessel-like networks in vitro and robust, patent, and functional vasculatures in vivo...
April 13, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28401807/biophysical-stimulation-for-engineering-functional-skeletal-muscle
#11
Sarah Somers, Alexander Spector, Douglas DiGirolamo, Warren L Grayson
Tissue engineering is a promising therapeutic strategy to regenerate skeletal muscle. However, ex vivo cultivation methods typically result in a low differentiation efficiency of stem cells as well as grafts that resemble the native tissues morphologically, but lack contractile function. The application of biomimetic tensile strain provides a potent stimulus for enhancing myogenic differentiation and engineering functional skeletal muscle grafts. We reviewed integrin-dependent mechanisms that potentially link mechanotransduction pathways to the upregulation of myogenic genes...
April 12, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28372485/a-review-of-cell-based-strategies-for-soft-tissue-reconstruction
#12
Elizabeth A Brett, Natalie Chung, Tripp Leavitt, Arash Momeni, Michael T Longaker, Derrick C Wan
Soft tissue reconstruction to restore volume to damaged or deficient tissue beneath the skin remains a challenging endeavor. Current techniques are centered around autologous fat transfer, or the use of synthetic substitutes, however a great deal of scientific inquiry has been made into both the molecular mechanisms involved in, as well as limitations of, de novo adipogenesis, i.e. the formation of new adipose tissue from precursor cells. To best comprehend these mechanisms, an understanding of defined markers for adipogenic differentiation, as well as knowledge of both commercially available and primary cell lines that enable in vitro and in vivo studies is necessary...
April 3, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28103751/three-dimensional-bioprinting-toward-the-era-of-manufacturing-human-organs-as-spare-parts-for-healthcare-and-medicine
#13
Tanveer Ahmad Mir, Makoto Nakamura
Three-dimensional (3D) printing technology has been used in industrial worlds for decades. Three-dimensional bioprinting has recently received an increasing attention across the globe among researchers, academicians, students, and even the ordinary people. This emerging technique has a great potential to engineer highly organized functional bioconstructs with complex geometries and tailored components for engineering bioartificial tissues/organs for widespread applications, including transplantation, therapeutic investigation, drug development, bioassay, and disease modeling...
March 21, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28166711/biomaterial-guided-gene-delivery-for-musculoskeletal-tissue-repair
#14
Justin L Madrigal, Roberta Stilhano, Eduardo A Silva
Gene therapy is a promising strategy for musculoskeletal tissue repair and regeneration where local and sustained expression of proteins and/or therapeutic nucleic acids can be achieved. However, the musculoskeletal tissues present unique engineering and biological challenges as recipients of genetic vectors. Targeting specific cell populations, regulating expression in vivo, and overcoming the harsh environment of damaged tissue accompany the general concerns of safety and efficacy common to all applications of gene therapy...
March 10, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28169595/tissue-derived-extracellular-matrix-bioscaffolds-emerging-applications-in-cartilage-and-meniscus-repair
#15
Farrah A Monibi, James L Cook
Musculoskeletal injuries are a common problem in orthopedic practice. Given the long-term consequences of unaddressed cartilage and meniscal pathology, a number of treatments have been attempted to stimulate repair or to replace the injured tissue. Despite advances in orthopedic surgery, effective treatments for cartilage and meniscus injuries remain a significant clinical challenge. Tissue engineering is a developing field that aims to regenerate injured tissues with a combination of cells, scaffolds, and signals...
March 7, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28142381/questions-and-challenges-in-the-development-of-mesenchymal-stromal-stem-cell-based-therapies-in-veterinary-medicine
#16
Lax R Devireddy, Lynne Boxer, Michael J Myers, Mark Skasko, Rudell Screven
The therapeutic potential of stem cells has fascinated those interested in treating diseases in both human and animal subjects. Although the exact mechanism of action and the definitive effectiveness of stem cell therapies remain unclear, animal owner perceptions and a desire for improved treatment options have fueled the interest of clinicians and stakeholders. Standards do not yet exist to define the critical attributes of mesenchymal stem/stromal cell (MSC)-based products derived from veterinary species such as the dog, cat, and horse...
February 28, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27824295/injectable-pore-forming-hydrogel-scaffolds-for-complex-wound-tissue-engineering-designing-and-controlling-their-porosity-and-mechanical-properties
#17
Robert M T Staruch, Graeme E Glass, Rory Rickard, Shehan P Hettiaratchy, Peter E M Butler
Traumatic soft tissue wounds present a significant reconstructive challenge. The adoption of closed-circuit negative pressure wound therapy (NPWT) has enabled surgeons to temporize these wounds before reconstruction. Such systems use porous synthetic foam scaffolds as wound fillers at the interface between the negative pressure system and the wound bed. The idea of using a bespoke porous biomaterial that enhances wound healing, as filler for an NPWT system, is attractive as it circumvents concerns regarding reconstructive delay and the need for dressing changes that are features of the current systems...
April 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27824290/design-and-use-of-chimeric-proteins-containing-a-collagen-binding-domain-for-wound-healing-and-bone-regeneration
#18
Cyril Addi, Frederic Murschel, Gregory De Crescenzo
Collagen-based biomaterials are widely used in the field of tissue engineering; they can be loaded with biomolecules such as growth factors (GFs) to modulate the biological response of the host and thus improve its potential for regeneration. Recombinant chimeric GFs fused to a collagen-binding domain (CBD) have been reported to improve their bioavailability and the host response, especially when combined with an appropriate collagen-based biomaterial. This review first provides an extensive description of the various CBDs that have been fused to proteins, with a focus on the need for accurate characterization of their interaction with collagen...
April 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27771996/how-regenerative-medicine-stakeholders-adapt-to-ever-changing-technology-and-regulatory-challenges-snapshots-from-the-world-termis-industry-symposium-september-10-2015-boston
#19
Yves Bayon, Mark Van Dyke, Robert Buelher, Ross Tubo, Tim Bertram, Bernard Malfroy-Camine, Michelle Rathman, Vincent Ronfard
Regenerative medicine (RM) is a fascinating area of research and innovation. The huge potential of the field has been fairly underexploited so far. Both TERMIS-AM and TERMIS-EU Industry Committees are committed to mentoring and training young entrepreneurs for more successful commercial translation of upstream research. With this objective in mind, the two entities jointly organized an industry symposium during the past TERMIS World Congress (Boston, September 8-11, 2015) and invited senior managers of the RM industry for lectures and panel discussions...
April 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27763207/potential-use-of-antiapoptotic-proteins-and-noncoding-rnas-for-efficient-in-vitro-follicular-maturation-and-ovarian-bioengineering
#20
Yoon Young Kim, Amin Tamadon, Seung-Yup Ku
In vitro culture of ovarian follicles is a promising bioengineering technique for preserving fecundity in reproductive-aged female by providing fertilizable oocytes. Successful clinical application should be preceded by developing the protocols that can efficiently overcome follicular cell apoptosis since the apoptosis is a critical phenomenon in in vivo folliculogenesis and in in vitro follicular maturation. Numerous prosurvival and antiapoptotic molecules, including follicular developmental regulators, have been reported to be involved in the intraovarian apoptosis...
April 2017: Tissue Engineering. Part B, Reviews
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