Marcelle Uiterwijk, Bram Coolen, Jan-Willem Rijswijk van, Serge Söntjens, Michel van Houtem, Wojciech Szymczyk, Laura Rijns, Henk Janssen, Allard Wal van der, Bas Mol de, Carlijn Bouten, Gustav Strijkers, Patricia Dankers, Jolanda Kluin
An essential aspect of cardiovascular in situ tissue engineering (TE) is to ensure balance between scaffold degradation and neo-tissue formation. We evaluated the degradation velocity and neo-tissue formation of three electrospun supramolecular bisurea-based biodegradable scaffolds that differ in their soft-block backbone compositions only. Scaffolds were implanted as interposition grafts in the abdominal aorta in rats, and evaluated at different time points (t = 1, 6, 12, 24 and 40 weeks) on function, tissue formation, strength and scaffold degradation...
February 29, 2024: Tissue Engineering. Part A