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European Annals of Allergy and Clinical Immunology

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https://www.readbyqxmd.com/read/28752724/crp-d-dimer-fibrinogen-and-esr-as-predictive-markers-of-response-to-standard-doses-of-levocetirizine-in-patients-with-chronic-spontaneous-urticaria
#1
P Kolkhir, D Pogorelov, O Olisova
According to current guidelines, non-sedative H1-antihistamines (nsAH) are the first-line therapy of chronic spontaneous urticaria (CSU). But even up-dosed antihistamines (to four times the standard dose) produce symptom resolution in less than 50% of patients. Biomarkers that can predict the response to nsAH are still unknown. We carried out a prospective study and used discriminant analysis to evaluate the combination of D-dimer, fibrinogen, C-reactive protein and ESR values for predicting the outcome of treatment with levocetirizine in 84 CSU patients...
July 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28752723/red-meat-allergy-induced-by-tick-bites-a-norwegian-case-report
#2
G Arslan Lied
Food allergies, especially delayed hypersensitivity reactions, are often challenging for both patients and clinicians. Here, we report the case of a 64-year-old man who had allergic reactions six hours after eating a meal containing red meat. He reported that he had several tick bites in months before the reaction. High serum specific IgE levels of alpha-gal confirmed the diagnosis of alpha-gal allergic reaction with delayed onset after red meat ingestion caused by tick bite.
July 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28752722/effects-of-food-allergy-on-the-dietary-habits-and-intake-of-primary-schools-cypriot-children
#3
E Vassilopoulou, C Christoforou, E Andreou, A Heraclides
Aim. To determine whether food allergy affects overall dietary intake and food choices in Cypriot primary school children. Methods. As part of the first epidemiological study in Cyprus on food allergy in primary school children, two 24-hour recalls (one from a week and one from a weekend day) of twenty-eight food allergic children (21 girls) and thirty healthy children (20 girls) aged 6-11 years old, were analysed and compared regarding their macro- and micronutrient content, food choices and meal distribution...
July 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28752721/phleum-pratense-molecular-pattern-across-italy
#4
G Ciprandi, E Scala, R Ariano
Introduction. Phleum pratense (Timothy grass) is the most frequent cause of grass allergy in Europe. Molecular-based allergy diagnostics have been recently introduced in the clinical practice, allowing to define and characterize exactly the sensitization profile. Aim of the study. The present study was aimed to investigate the possible relationships between Graminaceae pollen data and the pattern of IgE reactivity to different allergen components across Italy. Methods. Pollen data, including duration and quantity, were recorded over a 10-year period in 24 Italian centres located along the Italian peninsula...
July 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28752720/effects-of-omalizumab-treatment-on-serum-cytokine-concentrations-of-atopic-patients-with-chronic-spontaneous-urticaria-a-preliminary-report
#5
A Sellitto, U De Fanis, A Balestrieri, A Savoia, C Astarita, C Romano
Omalizumab has recently obtained indication for chronic spontaneous urticaria both in the US and Europe. However, the mechanism of action of this drug has yet to be fully elucidated. Previous studies have shown elevations in cytokine serum levels in patients with chronic spontaneous urticaria, and it is not known whether omalizumab treatment may affect cytokine serum levels in this condition. Besides, a proportion of chronic spontaneous urticaria patients have concomitant atopy, which may be associated, at least in theory, with prevalence of serum Th2-type cytokines...
July 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28752719/serum-estradiol-concentration-estradiol-to-progesterone-ratio-and-sputum-il-5-and-il-8-concentrations-are-increased-in-luteal-phase-of-the-menstrual-cycle-in-perimenstrual-asthma-patients
#6
A Semik-Orzech, S Skoczyński, W Pierzchała
Background. The results of the research on perimenstrual asthma (PMA) pathophysiology are inconsistent, and the role of sex hormones remains inconclusive. The aim of the study was to evaluate the influence of serum sex steroid (and other) hormones concentrations on lower airway inflammation of PMA patients. Methods. Thirty-three women of childbearing age diagnosed as: PMA (n = 13), non-PMA asthmatics (n = 10), and healthy controls (n = 10) were prospectively followed for 12 weeks over 2 consecutive menstrual cycles...
July 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28752718/histamine-release-positive-test-associates-with-disease-remission-in-chronic-spontaneous-urticaria-a-proof-of-concept-study
#7
A Berti, M R Yacoub, P Stahl Skov, S Falkencrone, L Casati, S Burastero, M G Sabbadini, G Colombo
Background. Histamine release (HR) test has previously been shown to predict the presence of endogenous histamine-releasing factors in chronic spontaneous urticaria (CSU). Objectives and methods. Twenty CSU patients unresponsive to antihistamine treatment were enrolled in order to evaluate the correlations between HR test results and demographic features, quality of life, disease activity, clinical course, and autologous serum and plasma skin tests (ASST and APST). Results. All patients with positive HR test (9/9, 100%) had a more severe disease activity at onset (urticaria activity score, UAS > 2) when compared to negative HR test patients (5/11; p = 0...
July 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28752717/justification-for-ige-as-a-therapeutic-target-in-chronic-spontaneous-urticaria
#8
M Sánchez-Borges, A Capriles-Hulet, F Caballero-Fonseca, L González-Aveledo
Monoclonal anti-IgE antibodies (omalizumab) are able to induce clinically significant benefits in patients with severe chronic spontaneous urticaria (CS). Those results led clinicians and investigators to reconsider a possible pathogenic role not previously supported for IgE and its receptors in this disease, and to investigate additional approaches for understanding its pathogenesis. IgE antibodies to unknown environmental allergens able to trigger chronic urticaria are not generally regarded as the etiologic factor for the disease...
July 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28497679/disappearance-of-severe-oral-allergy-syndrome-following-omalizumab-treatment
#9
R Asero
The first case of disappearance of apple-induced oral allergy syndrome in a birch pollen-allergic patient following omalizumab treatment is reported. This observation in a case of type 2 food allergy suggests that omalizumab is potentially an effective preventive treatment for patients with severe, type 1 food allergies.
May 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28497678/eosinophil-fungal-rhinosinusitis-caused-by-fusarium-infection-secondary-to-odontogenic-maxillary-sinus-disease-when-collaboration-between-otolaryngologist-and-allergologist-leads-to-the-correct-diagnosis-and-therapy
#10
P Gamba, C Lombardi
Rhinitis and sinusitis usually coexist and are concurrent in most individuals; thus, the correct terminology is now "rhinosinusitis". On the basis of numerous causative factors, often co-existing in the same patient, the diagnosis of rhinosinusitis is also made by a wide variety of practitioners (allergologists, otolaryngologists, pulmonologists, primary care physicians, paediatricians, and many others). Approximately 5-15% of the population suffers from chronic rhinosinusitis, and in 10-12% of them, it is of dental origin...
May 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28497677/successful-of-subcutaneous-and-oral-hyposensitizing-therapy-in-30-patients
#11
A Tammaro, I Romano, F R Parisella, G De Marco, F Persechino, I Trimarchi, S Persechino
Background. Pharmacotherapy and immunotherapy are the main treatment modalities for respiratory allergy. The aim of this paper has been to evaluate the efficacy and tolerability of subcutaneous and sublingual immunotherapy in association in allergic patients, and to demonstrate that the patients who have performed a second oral vaccination cycle after 4-5 years from the first subcutaneous treatment, derive benefits that may last for years. This is due to immune system's plasticity. Methods. The study was conducted in 30 allergic patients which had previously executed a full cycle of classical subcutaneous immunotherapy, with a partial remission of symptoms...
May 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28497676/assessment-of-validity-and-reliability-of-drug-hypersensitivity-quality-of-life-questionnaire-the-dutch-experience
#12
M Moayeri, H Van Os-Medendorp, I Baiardini, H Röckmann
Drug Hypersensitivity Quality of Life Questionnaire (DrHy-Q) is the first questionnaire that captures health related quality of life impact in patients with drug hypersensitivity. The aim of this study was to translate and validate the original Italian 15-item DrHy-Q for use among Dutch-speaking residents. We also compared the DrHy-Q scores obtained across countries. In a prospective cohort study, the Dutch DrHy-Q was completed by 124 patients (65.3% female, age 56.8 ± 14.0) with a confirmed drug hypersensitivity...
May 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28497675/evaluation-of-pulmonary-complications-in-patients-with-primary-immunodeficiency-disorders
#13
M Reisi, G Azizi, F Kiaee, F Masiha, R Shirzadi, T Momen, H Rafiemanesh, N Tavakolinia, M Modaresi, A Aghamohammadi
Background. Primary immunodeficiencies (PIDs) are inherited disorders in which one or several components of immune system are defected. Moreover, affected patients are at high risk for developing recurrent infections, particularly pulmonary infections. The spectrum of pulmonary manifestations in PIDs is broad, and includes acute and chronic infection, structural abnormalities (eg, bronchiectasis), malignancy and dysregulated inflammation resulting in tissue damage. In this study, our aims are to evaluate pulmonary complications in PID patients...
May 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28497674/the-vespid-allergy-quality-of-life-questionnaire-cultural-adaptation-and-translation-to-portuguese
#14
D Silva, A M Pereira, N Santos, L Amaral, L Delgado, J N Oude Elberink, A Coimbra
A cross-cultural translation of the Vespid Allergy Quality of Life Questionnaire (VQLQ) to the Portuguese population (VQLQ-P) was performed, assessing its applicability in wasp and in non-beekeeper bee venom allergic patients. Additionally, we evaluated a Visual Analogue Scale (VAS) to estimate hymenoptera allergy interference with daily life. Methods. Cross-cultural translation was performed according to recommendations. The final VQLQ-P version, the Expectation of Outcome questionnaire (EoQ), EQ-5D and VAS were applied to wasp (n = 19) and non-beekeeper bee venom allergic patients (n = 30)...
May 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28497673/body-mass-index-and-skin-reactivity-to-histamine-and-dermatophagoides-pteronyssinus-in-children-and-adolescents-followed-in-a-pediatric-allergy-service
#15
A Keller Franco, R Oselka Sarni, M Carvalho Mallozi, D Solé
Rationale. Recent data suggest that the nutritional status assessed by body mass index (BMI) is positively associated with skin reactivity to histamine in children. Objective. To study the relation between BMI and skin reactivity to histamine and Dermatophagoides pteronyssinus in allergic children and adolescents. Methods. The medical charts of patients attended in our outpatient clinic between 2013 and 2014 (n = 972) were evaluated. Only patients with asthma, allergic rhinitis or wheezing infants sensitized to at least one aeroallergen were selected: a total of 626 patients (6 months to 19 year-olds; 60...
May 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28497672/allergic-and-nonallergic-rhinitis-and-skin-sensitization-to-metals-is-there-a-link
#16
M Gelardi, R Guarino, S Taliente, N Quaranta, A Carpentieri, G Passalacqua
Background. Chromium, Cobalt and Nickel are responsible for contact dermatitis, that is largely prevalent in the general population. They can act also as irritants in the upper and lower respiratory airways. Also rhinitis (allergic and nonallergic) is a high prevalence disorder. Both diseases could share some common inflammatory mechanisms, but the clinical association between skin sensitization to metals and rhinitis was never studied. Objective. We assessed the presence of skin sensitization to metals in subjects with rhinitis...
May 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28497671/perceived-efficacy-and-satisfaction-of-patients-with-subcutaneous-hypoallergenic-high-dose-house-dust-mite-extract
#17
A Roger Reig, M Ibero Iborra, T Carrillo Díaz, R López Abad, V Sánchez Moreno, J Álvarez Nieto, N Cancelliere
The efficacy and safety of subcutaneous immunotherapy with modified, high-dose, major allergen house dust mite extract is widely supported by double-blind, placebo-controlled studies. However, little is known regarding patient-perceived efficacy and satisfaction. An observational, retrospective, multicentre study in patients treated with Acaroid(®) was conducted to assess the efficacy and degree of satisfaction of the patients after the first six months of treatment with it. All the clinical study procedures were performed according to the routine clinical practice...
May 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28294591/letter-to-the-editor-can-dog-allergen-immunotherapy-reduce-concomitant-allergic-sensitization-to-other-furry-animals-a-preliminary-experience
#18
G Liccardi, L Calzetta, A Salzillo, L Billeri, G Lucà, P Rogliani
It has been shown that allergen immunotherapy (AIT) is effective in reducing symptoms of allergic asthma and rhinitis. Data on the efficacy are less convincing with regard to AIT for allergens of common pets (cats/dogs). We describe a case of dog allergy in which we explored if dog AIT (DAI) could reduce a concomitant allergic sensitization to other allergens of furry animals. Our case demonstrates the efficacy of sublingual DAI on SPTs, symptom score, and spirometric responses despite persistent exposure to dog allergens at home in a patient sensitized, but not exposed, to several other furry animals...
March 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28294590/successful-omalizumab-treatment-in-hiv-positive-patient-with-chronic-spontaneous-urticaria-a-case-report
#19
E Iemoli, F Niero, L Borgonovo, M V Cossu, S Piconi
We described a case of a 56 year old homosexual HIV positive man who presented a history of CSU since one year (2012). All the allergologic, immunologic and microbiologic tests to evaluate the pathogenesis of wheals resulted negative. Therefore in June 2015 we decided to start therapy with Omalizumab while the patient kept on effective antiretroviral therapy with 310 cells/mm3 TCD4 counts and undetectable HIV viremia. After two monthly subcutaneuous injection of 150 mg of Omalizumab the patient had no more urticarial symptoms...
March 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28294589/selective-hypersensitivity-to-cefazolin-and-contribution-of-the-basophil-activation-test
#20
J P Almeida, A Lopes, A Campos Melo, M C Pereira Santos, M Pereira Barbosa
The authors present 2 case reports of selective cefazolin hypersensitivity: a 49 year-old woman with a history of two perioperative reactions (urticaria and severe anaphylaxis) after the use of rocuronium, propophol and cefazolin; a 36 year-old pregnant woman who developed facial erythema, lips angioedema and hypotension immediately after administration of ropivacain, sufentanil, cefazolin, oxytocin and ephedrine. In both cases, intradermal skin tests were positive for cefazolin. A basophil activation test was performed for cefazolin, which was positive in one patient...
March 2017: European Annals of Allergy and Clinical Immunology
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