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European Annals of Allergy and Clinical Immunology

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https://www.readbyqxmd.com/read/29542892/lipid-transfer-protein-sensitization-in-an-apple-allergic-patient-a-case-report-from-northern-europe
#1
A Gülsen, U Jappe
We describe a case of a woman who developed three separate episodes of urticaria and ana-phylaxis during exercise after consuming an apple, with immunological evidence that nonspecific lipid transfer proteins (LTP) may have been responsible for these reactions. LTP sensitivity can cause life-threatening allergies and anaphylaxis. Although LTP sensitization is common in Mediterranean countries, the frequency of knowledge and diagnoses is increasing in Europe. Despite the geographic differences, LTP allergy should be kept on sight when facing severe anaphylaxis after consuming LTP-included food...
March 2, 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29533055/effect-of-industrial-processing-on-the-ige-reactivity-of-three-commonly-consumed-mo-roccan-fish-species-in-fez-region
#2
N Mejrhit, O Azdad, L Aarab
Objectives. The aim of this work was to study the effect of industrial processing on the allergenicity of three commonly consumed Moroccan fish species in Fez region (sardine, common pandora, and shrimp). Methods. This work was conducted by a sera-bank obtained from 1248 patients recruited from Fez Hospitals. Their sera were analyzed for specific IgE binding to raw fish extracts. Among them, 60 patients with higher specific IgE levels were selected, and used to estimate the binding variation of IgE to these products under several processing (frying, cooking, canning, marinade, and fermentation) using ELISA analysis...
March 2, 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29533054/reduction-of-the-allergenicity-of-cow-s-milk-%C3%AE-lactalbumin-under-heat-treatment-and-enzymatic-hydrolysis-in-moroccan-population
#3
O Azdad, N Mejrhit, L Aarab
The aim of the present study is to evaluate the effect of heat-treatment and enzymatic hydrolysis on the allergenicity of cow's milk α-lactalbumin (α-LA) in a Moroccan population. A total of 557 patients were recruited from the University Hospital Complex and the Ibn El Khatib Hospital of Fez city. This population consented to realize a dosage of IgE levels to raw cow milk and then to α-LA native and treated with the studied treatments. The results revealed that 54.4% of the studied subjects presented positive values of serial IgE to raw cow milk...
March 1, 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29384116/anaphylaxis-in-a-food-allergy-outpatient-department-one-year-review
#4
R A Fernandes, F Regateiro, C Pereira, E Faria, J Pita, A Todo-Bom, I Carrapatoso
Background. Anaphylaxis is an acute, potentially fatal, multi-organ allergic reac-tion. Our aim was to characterize the population with food induced anaphylaxis followed over a one-year period. Methods. Retrospective analysis of clinical files of patients with food anaphylaxis observed in our food allergy consultation during 2016. Results. Sixty-two patients were included. In the pediatric group, the implicated allergens were cow's milk, egg and fish and in the adults' group, the commonest allergens were nuts and wheat...
March 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29384111/immunogenetics-of-cytokine-genes-in-parthenium-dermatitis-a-review
#5
REVIEW
N Akhtar, K K Verma, A Sharma
Parthenium dermatitis is a chronic immuno-inflammatory, distressing skin disease and is mediated by activated T-lymphocyte which is primarily manifested on the exposed sites of the face, neck, hand and flexures. Parthenium hysterophorus is ubiquitous, hence it is diffi-cult to avoid the aero-allergenic antigen parthenin, responsible for the contact dermatitis. The pathogenesis of parthenium dermatitis is characterized by infiltration of T-lymphocytes into challenged skin sites and the development of a cutaneous inflammation due to altered regulatory network of pro and anti-inflammatory cytokines...
March 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29384110/systematic-investigation-for-underlying-causes-of-recurrent-infections-in-children-surveillance-of-primary-immunodeficiency
#6
S Yousefzadegan, M Tavakol, H Abolhassani, A Nadjafi, S Mansouri, R Yazdani, G Azizi, B Negahdari, N Rezaei, A Aghamohammadi
Recurrent infections seem to be a common complaint in children who are referred to general practitioners and pediatricians offices. Detection of primary immunodeficiencies (PID) etiology is very important for achieving appropriate diagnosis and treatment of these patients. The absence of appropriate treatment could lead to subsequent complications, in a hospital inpatient and/or outpatient settings. This study was performed in a group of children with recurrent infections to identify patients with underlying PID...
March 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29384109/local-anesthetics-allergy-who-should-be-tested
#7
I YIlmaz, S K Özdemir, Ö Aydin, G E Çelik
Objective. To document the test results of patients referred to our clinic for testing with local anesthetics (LAs) in real life conditions and provide data related to the necessity of these tests. Methods. All consecutive subjects who were referred to be evaluated for LA allergy during a two-year follow up were included in the analysis. All subjects underwent skin prick / intradermal tests followed by a subcutaneous provocation test with the LAs tested. Results. A total of 228 subjects were included. The main referral reason was the presence of a history of drug hypersensitivity reaction (DHR) to drugs other than LAs (n = 128; 56%), whereas a history of LA allergy constituted the second most common referral reason (n = 64, 28...
March 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29384106/recommendations-for-the-use-of-molecular-diagnostics-in-the-diagnosis-of-allergic-dis-eases
#8
REVIEW
D Villalta, E Tonutti, N Bizzaro, I Brusca, V Sargentini, R Asero, M B Bilo, G Manzotti, F Murzilli, L Cecchi, A Musarra
The Study Group on Allergology of the Italian Society of Clinical Pathology and Laboratory Medicine (SIPMeL) and the Associazione Italiana degli Allergologi e Immunologi Territoriali e Ospedalieri (AAIITO) developed the present recommendations on the diagnosis of allergic diseases based on the use of molecular allergenic components, whose purpose is to provide the pathologists and the clinicians with information and algorithms enabling a proper use of this second-level diagnostics. Molecular diagnostics allows definition of the exact sensitization profile of the allergic patient...
March 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29384104/successful-rapid-subcutaneous-desensitization-to-anakinra-in-a-case-with-a-severe-immediate-type-hypersensitivity-reaction
#9
I YIlmaz, M Türk, S Nazik Bahçecioğlu
Anakinra, one of the novel biological agents, is a recombinant human IL-1 receptor antagonist. It is preferred as an alternative drug for familial Mediterranean fever cases where colchicine is not sufficient or cannot be used due to its side effects. Like all other biologics, hypersensitivity reactions to anakinra are quite rare. This is the first case which was successfully desensitized with anakinra after a severe immediate-type hypersensitivity reaction.
March 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29383926/piperacillin-tazobactam-anaphylaxis-a-rare-cause-of-occupational-disease
#10
J Gaspar-Marques, E Finelli, P C Martins, S Prates, P Leiria-Pinto
Piperacillin is a beta-lactam antibiotic of penicillin family. Some penicillins were report-ed as occupational diseases cause, but piperacillin anaphylaxis with occupational sensi-tization is rare. We describe the case of a female nurse with recurrent anaphylaxis in last few months without apparent cause, only in work environment. Latex allergy was excluded after negative latex glove provocation. Later during diagnostic workup, the patient reported a similar reaction minutes after piperacillin preparation. She denied any previous antibiotic therapeutic exposure...
March 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29533053/oral-allergy-syndrome-amongst-young-mexicans-prevalence-and-associated-factors
#11
M Bedolla-Barajas, T R Bedolla-Pulido, M V Flores-Merino, A Jiménez-Rosales, M V Domínguez-García
Background. Oral allergy syndrome (OAS) is the most common food allergy manifestation amongst adults. However, population studies aimed at estimating its prevalence and associated factors are scarce in Mexi-co. Objectives. To establish the prevalence of OAS in a sample of university students and to describe their clinical characteristics and its associated factors. Methods. From a sample group made up of 25,269 univer-sity students, the data corresponding to 1,200 students aged 18 to 25 was analyzed with a cross-sectional approach...
February 28, 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29533052/histamine-release-test-in-angioedema-patients-without-urticaria-a-retrospective-co-hort-study-of-404-patients
#12
G Authried, S C Prasad, E Rye Rasmussen, A Bygum
A subset of patients with angioedema (AE) and urticaria has histamine releasing autoanti-boies. The histamine release test (HR-test) has been used as a tool in chronic urticaria to de-fine the autoimmune subgroup and may possibly guide the clinician to a more personalized therapy, like omalizumab and cyclosporine. The prevalence and value of positive histamine releasing autoantibodies in monosymptomatic AE is sparsely described in the literature. The purpose of this study was to report the prevalence of positive histamine releasing autoanti-bodies in a cohort of patients with recurrent AE and evaluate the usefulness of this test in AE patients...
February 19, 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29542889/allergy-to-ltp-to-eat-or-not-to-eat-sensitizing-foods-a-follow-up-study
#13
R Asero, M Piantanida, V Pravettoni
Background. Follow-up data about the onset of novel food allergies in patients allergic to lipid transfer protein (LTP) are missing. We investigated the occurrence of novel allergies over time in LTP hypersensitive patients. Methods. Sixty-seven LTP-allergic patients recommended to avoid foods responsible for systemic reactions and encouraged to eat other sensitizing foods avoiding the association with known co-factors, were re-evaluated after ≥ 1 year to assess the occurrence of allergy to novel foods. IgE to rPru p 3, rBet v 1, and r Phl p 12 were measured...
February 16, 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29479929/storage-molecules-from-tree-nuts-seeds-and-legumes-relationships-and-amino-acid-identity-among-homologue-molecules
#14
REVIEW
E Scala, D Villalta, G Meneguzzi, M Giani, R Asero
The families of seed storage proteins, together with profilins, oil-bodies-associated oleosins, and pathogenesis-related (PR) proteins like PR-10 (Bet v 1-like), PR-12 (defensins) and PR-14 (non-specific lipid transfer protein), are the main causes of IgE sensitization to tree nuts, legumes and seeds. All these allergens, with the exclusion of profilins and of PR-10, are heat-stable and possibly responsible for fatal or almost fatal adverse reactions to such foods. In this short review, we will discuss the relationship and amino acid identities among some of the seed storage homologue molecules identified to date from tree nuts, seeds and legumes...
February 1, 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29479937/role-of-nasal-challenge-and-local-eosinophilia-in-indirect-exposure-to-cat-in-allergic-rhinitis-patients
#15
M Al Ahmad, N Arifhodzic, J Nurkic, E Jusufovic, A L Hanoun, T Rodriguez
Introduction. Sensitization to cat allergens is common worldwide. Currently, there is a trend towards costly and often unavailable diagnostic analysis. Objectives. The aim is to assess the reliability of skin prick test (SPT) and serum specific IgE (ssIgE) to cat sensitization, by performing nasal challenge test (NCT) in a community with low cat ownership but common presence of stray cats. Patients and methods. Forty-one pa-tients with perennial allergic rhinitis (AR) who were mono or polysensitized (including cat) were included...
January 17, 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29479938/omalizumab-in-chronic-spontaneous-and-inducible-urticaria-a-9-year-retrospective-study-in-portugal
#16
J Marcelino, A C Costa, A Mendes, E Alonso, F Cabral Duarte, E Pedro, M Pereira-Barbosa
Objective. Describe the safety and long-term use of omalizumab in chronic urticaria (CU), both spontaneous (CSU) and inducible (CIndU). Methods. Retrospective chart-review (2006-15) of CU patients treated with omalizumab for ≥ 6 months. Statistical analyses: descriptive statistics, Mann-Whitney, generalized linear models. Results. 23 patients with CSU (3 men), 3 with CIndU (2 men). Generalized linear models showed UAS reduction per omalizumab administration of 16% in CIndU and CSU and UAS7, of 15% in CIndU, and 20% in CSU...
January 16, 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29479928/latex-sensitization-in-patients-with-myelomeningocele-contribution-of-microarray-technique
#17
A B de Sá, L C Oliveira, R Camilo, F F Pierotti, D Solé
Background. Microarray technique employing molecular allergens is pointed out as a new method to evaluate allergic patients. Objective. To evaluate if microarray technique (ImmunoCAP-ISAC®; I-ISAC®) is similar to fluorescence enzyme immunoassay (FEIA; ImmunoCAP®) in the diagnosis of latex allergy (specific IgE to latex plus symptoms) and latex sensitization (only antibody) in pediatric (9-mo to 14-yrs) patients with myelomeningocele undergone to surgical repair. Methods. Patients underwent skin prick testing (SPT) to latex and food (prick to prick), and dosage of serum specific IgE to latex and recombinant latex allergens (rHev b 1, rHev b 3, rHev b 5, rHev b 6...
January 15, 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29479927/galactose-%C3%AE-1-3-galactose-allergy-a-rare-syndrome-and-an-atypical-presentation
#18
C Abreu, B Bartolomé, L Cunha, H Falcão
Allergies to red meat associated with galactose-α-1,3-galactose, commonly known as α-gal, are rare and have only recently been described. At this time, the literature reports only one case documented in Portugal. In this study, we report the case of a 76-year-old male with an immediate reaction following the ingestion of red meat. Rigorous diagnostic exams, including prick test, prick-to-prick tests, serum specific IgE and SDS-PAGE IgE-immunoblotting, were performed. The α-gal epitope IgE re-turned a value of 35...
January 15, 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29479926/fecal-microbiota-profile-in-atopic-asthmatic-adult-patients
#19
A M Okba, S M Saber, A S Abdel-Rehim, M M Amin, D A Mohamed
Background. Studies proposed a link between gut microbiota and airway tract. Objective. Study the diversity and density of gut microbiota in healthy and asthmatic patients. Method. Semi-quantitative stool cultures were performed from fecal samples collected from 80 adult asthmatic patients and 40 healthy individuals. Data on gender, age, dietetic history, clinical examination and investigations as skin prick test and pulmonary function testing were also collected. Results. Lactobacilli were found to be higher among patient group than control group...
January 15, 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29350022/an-unusual-case-of-positive-sige-to-galactose-alpha-1-3-galactose-from-south-italy
#20
C G Uasuf, A Torina, V Ferrantelli, I Brusca
We report the case of a 38-year-old man who was bitten several times during his life by a tick. He didn't report any previous history of anaphylaxis after the ingestion of red meat. The serum specific IgE showed positivity to α-Gal. The proximity of the bits didn't increase the titer of IgE antibodies to alpha-gal. We could hypothesize that the frequency of the exposure to the tick Corresponding author bites and the amount of tick bites during his lifetime induced a sort of tolerance in this patient.
January 2018: European Annals of Allergy and Clinical Immunology
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