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Brain Stimulation

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https://www.readbyqxmd.com/read/28642024/rtms-with-a-two-coil-array-safety-and-efficacy-for-treatment-resistant-major-depressive-disorder
#1
Linda L Carpenter, Scott T Aaronson, Gregory N Clarke, Paul E Holtzheimer, Clark W Johnson, William M McDonald, Elizabeth L Stannard, M Bret Schneider
BACKGROUND: Therapeutic repetitive Transcranial Magnetic Stimulation (rTMS) has emerged as a standard of care for individuals with major depressive disorder (MDD) who do not benefit from, or are unable to tolerate, antidepressant pharmacotherapy. Depth of stimulation is limited with currently approved figure-eight coils and larger coils capable of deeper penetration may be associated with loss of stimulation focality and undesired recruitment of motor cortex. A second generation 2-coil array rTMS system was designed to target converging brain pathways for potentially deeper prefrontal cortex stimulation...
June 9, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28629874/neural-activity-during-attentional-conflict-predicts-reduction-in-tinnitus-perception-following-rtms
#2
G A James, J D Thostenson, G Brown, G Carter, H Hayes, S P Tripathi, D J Dobry, R B Govindan, J L Dornhoffer, D K Williams, C D Kilts, M S Mennemeier
BACKGROUND: Subjective idiopathic tinnitus is an intrusive, distracting, and potentially disabling disorder characterized by phantom perception of sounds. Although tinnitus has no approved pharmacologic treatment, recent evidence supports the use of repetitive transcranial magnetic stimulation (rTMS) to alleviate tinnitus symptoms. OBJECTIVE/HYPOTHESIS: Repetitive TMS delivered over the middle superior temporal gyrus (STG) may alter ratings of tinnitus awareness and annoyance more than loudness due to change in attentional processing...
June 2, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28624346/theta-burst-magnetic-stimulation-over-the-pre-supplementary-motor-area-improves-motor-inhibition
#3
Ignacio Obeso, Leonora Wilkinson, James T Teo, Penelope Talelli, John C Rothwell, Marjan Jahanshahi
BACKGROUND: Stopping an ongoing motor response or resolving conflict induced by conflicting stimuli are associated with activation of a right-lateralized network of inferior frontal gyrus (IFG), pre-supplementary motor area (pre-SMA) and subthalamic nucleus (STN). However, the roles of the right IFG and pre-SMA in stopping a movement and in conflict resolution remain unclear. We used continuous theta burst stimulation (cTBS) to examine the involvement of the right IFG and pre-SMA in inhibition and conflict resolution using the conditional stop signal task...
May 22, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28566194/non-invasive-vagus-nerve-stimulation-acutely-improves-spontaneous-cardiac-baroreflex-sensitivity-in-healthy-young-men-a-randomized-placebo-controlled-trial
#4
Diego Antonino, André L Teixeira, Paulo M Maia-Lopes, Mayara C Souza, Jeann L Sabino-Carvalho, Aaron R Murray, Jim Deuchars, Lauro C Vianna
BACKGROUND: Despite positive outcomes of transcutaneous vagus nerve stimulation (tVNS) via the auricular branch of the vagus nerve (ABVN), the mechanisms underlying these outcomes remain unclear. Additionally, previous studies have not been controlled the possible placebo effects of tVNS. OBJECTIVE: To test the hypothesis that tVNS acutely improves spontaneous cardiac baroreflex sensitivity (cBRS) and autonomic modulation, and that these effects are specific to stimulation of ABVN...
May 19, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28566193/efficacy-of-transcranial-direct-current-stimulation-over-primary-motor-cortex-anode-and-contralateral-supraorbital-area-cathode-on-clinical-pain-severity-and-mobility-performance-in-persons-with-knee-osteoarthritis-an-experimenter-and-participant-blinded-randomized
#5
Hyochol Ahn, Adam J Woods, Mark E Kunik, Abhishek Bhattacharjee, Zhiguo Chen, Eunyoung Choi, Roger B Fillingim
BACKGROUND: Previous studies indicate that transcranial direct current stimulation (tDCS) with anode over motor cortex (M1) and cathode over contralateral supraorbital region (SO) may be effective in reducing pain, but these studies are limited in number and have not focused on older adults with osteoarthritis (OA). OBJECTIVE: To evaluate the preliminary efficacy and safety of M1-SO applied tDCS on clinical pain severity and mobility performance in adults with knee OA pain...
May 19, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28551318/anatomical-and-functional-correlates-of-cortical-motor-threshold-of-the-dominant-hand
#6
Charlotte Rosso, Vincent Perlbarg, Romain Valabregue, Mickaël Obadia, Claire Kemlin-Méchin, Eric Moulton, Sara Leder, Sabine Meunier, Jean-Charles Lamy
BACKGROUND: Resting Motor threshold (rMT) provides information about cortical motor excitability. Interestingly, the influences of the structural or functional variability of the motor system on the rMT inter-individual variability have been poorly investigated. OBJECTIVE/HYPOTHESIS: To investigate relationships between rMT and measures of brain structures and function of the motor system. The hypothesis is that cortical excitability not only depends on the primary motor cortex (M1) but also on the integration of information originating from its vicinity such as premotor (PMd and SMA) and post-central (S1) cortices...
May 17, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28545769/effects-of-repetitive-tms-of-the-motor-cortex-on-disease-progression-and-on-glutamate-and-gaba-levels-in-als-a-proof-of-principle-study
#7
LETTER
Vincenzo Di Lazzaro, Giovanni Pellegrino, Federico Ranieri, Lucia Florio, Gabriella Musumeci, Massimo Caulo, Antonio Ferretti, Fioravante Capone
No abstract text is available yet for this article.
May 17, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28551319/long-term-effects-of-prefrontal-tdcs-on-multiple-sclerosis-fatigue-a-case-study
#8
LETTER
Samar S Ayache, Jean-Pascal Lefaucheur, Moussa A Chalah
No abstract text is available yet for this article.
May 16, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28545770/neuro-cardiac-guided-tms-ncg-tms-probing-dlpfc-sgacc-vagus-nerve-connectivity-using-heart-rate-first-results
#9
LETTER
Tabitha A Iseger, Frank Padberg, J Leon Kenemans, Richard Gevirtz, Martijn Arns
BACKGROUND: Given that many studies suggest a role of DLPFC-sgACC connectivity in depression and prior research demonstrating that neuromodulation of either of these nodes modulates parasympathetic activity and results in a heart rate deceleration, a new method is proposed to individualize localization of the DLPFC. This can, among others, be useful for rTMS treatment of depression. METHODS: Ten healthy subjects received three trains of 10Hz rTMS randomly over 7 target regions (10-20 system)...
May 12, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28528736/on-the-effectiveness-of-event-related-beta-tacs-on-episodic-memory-formation-and-motor-cortex-excitability
#10
Verena Braun, Rodika Sokoliuk, Simon Hanslmayr
BACKGROUND: Transcranial alternating current stimulation (tACS) is widely used to entrain or modulate brain oscillations in order to investigate causal relationships between oscillations and cognition. OBJECTIVE: In a series of experiments we here addressed the question of whether event-related, transient tACS in the beta frequency range can be used to entrain beta oscillations in two different domains: episodic memory formation and motor cortex excitability. METHODS: In experiments 1 and 2, 72 healthy human participants engaged in an incidental encoding task of verbal and non-verbal material while receiving tACS to the left and right inferior frontal gyrus (IFG) at 6...
April 30, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28551320/effects-of-chronic-abdominal-vagal-stimulation-of-small-diameter-neurons-on-brain-metabolism-and-food-intake
#11
Charles-Henri Malbert, Eric Bobillier, Chloé Picq, Jean-Louis Divoux, David Guiraud, Christine Henry
BACKGROUND: Abdominal bilateral vagal stimulation reduces food intake in animals. However, the classical square wave, mA range current generator is poorly effective to evoke action potentials on A∂ and C neurons that represent the majority of vagal neurons at the abdominal level. OBJECTIVE/HYPOTHESIS: METHODS: The current thresholds for pulsons (S2 & S3) and millisecond pulses (S1) required to trigger action potentials were calculated in 5 anaesthetized pigs using single fibre recording...
July 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28522346/seeing-in-the-dark-phosphene-thresholds-with-eyes-open-versus-closed-in-the-absence-of-visual-inputs
#12
T A de Graaf, F Duecker, Y Stankevich, S Ten Oever, A T Sack
BACKGROUND: Voluntarily opening or closing our eyes results in fundamentally different input patterns and expectancies. Yet it remains unclear how our brains and visual systems adapt to these ocular states. OBJECTIVE/HYPOTHESIS: We here used transcranial magnetic stimulation (TMS) to probe the excitability of the human visual system with eyes open or closed, in the complete absence of visual inputs. METHODS: Combining Bayesian staircase procedures with computer control of TMS pulse intensity allowed interleaved determination of phosphene thresholds (PT) in both conditions...
July 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28506878/pain-motor-integration-in-the-primary-motor-cortex-in-parkinson-s-disease
#13
A Suppa, C Leone, F Di Stasio, L Marsili, A Di Santo, A Biasiotta, S La Cesa, A Truini, G Cruccu, A Berardelli
BACKGROUND: In Parkinson's disease (PD), the influence of chronic pain on motor features has never been investigated. We have recently designed a technique that combines nociceptive system activation by laser stimuli and primary motor cortex (M1) activation through transcranial magnetic stimulation (TMS), in a laser-paired associative stimulation design (Laser-PAS). In controls, Laser-PAS induces long-term changes in motor evoked potentials reflecting M1 long-term potentiation-like plasticity, arising from pain-motor integration...
July 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28501325/a-role-for-nmdar-dependent-cerebellar-plasticity-in-adaptive-control-of-saccades-in-humans
#14
S Colnaghi, P Colagiorgio, M Versino, G Koch, E D'Angelo, S Ramat
BACKGROUND: Saccade pulse amplitude adaptation is mediated by the dorsal cerebellar vermis and fastigial nucleus. Long-term depression at the parallel fibre-Purkinjie cell synapses has been suggested to provide a cellular mechanism for the corresponding learning process. The mechanisms and sites of this plasticity, however, are still debated. OBJECTIVE: To test the role of cerebellar plasticity phenomena on adaptive saccade control. METHODS: We evaluated the effect of continuous theta burst stimulation (cTBS) over the posterior vermis on saccade amplitude adaptation and spontaneous recovery of the initial response...
July 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28487047/anodal-and-cathodal-electrical-stimulation-over-v5-improves-motion-perception-by-signal-enhancement-and-noise-reduction
#15
Luca Battaglini, Stefano Noventa, Clara Casco
BACKGROUND: The effect that transcranial direct current stimulation (tDCS) has on discrimination of coherent motion (CM) signals in a field of randomly moving dots (noise) can be accounted for by both noise reduction and signal enhancement. OBJECTIVE: To distinguish between noise reduction and signal enhancement, we monitored the discrimination of the correct CM direction as a function of the coherence level (using the psychophysical method of constant stimuli)...
July 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28476496/a-case-of-coenesthetic-hallucinations-treated-with-low-frequency-repetitive-transcranial-magnetic-stimulation
#16
LETTER
Allam Nasser, Juliana Sousa Batista, Pedro Brandão, Talyta Grippe
No abstract text is available yet for this article.
July 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28462882/first-clinical-use-of-epidural-stimulation-in-catatonia
#17
LETTER
Emmanuel Stip, Paul Lespérance, Olivier Farmer, Marie-Pierre Fournier-Gosselin
No abstract text is available yet for this article.
July 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28462881/safety-and-efficacy-of-long-term-home-treatment-with-transcranial-direct-current-stimulation-tdcs-in-a-case-of-multimodal-hallucinations
#18
LETTER
Tobias Schwippel, Barbara Wasserka, Andreas J Fallgatter, Christian Plewnia
No abstract text is available yet for this article.
July 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28461068/coil-optimisation-for-transcranial-magnetic-stimulation-in-realistic-head-geometry
#19
Lari M Koponen, Jaakko O Nieminen, Tuomas P Mutanen, Matti Stenroos, Risto J Ilmoniemi
BACKGROUND: Transcranial magnetic stimulation (TMS) allows focal, non-invasive stimulation of the cortex. A TMS pulse is inherently weakly coupled to the cortex; thus, magnetic stimulation requires both high current and high voltage to reach sufficient intensity. These requirements limit, for example, the maximum repetition rate and the maximum number of consecutive pulses with the same coil due to the rise of its temperature. OBJECTIVE: To develop methods to optimise, design, and manufacture energy-efficient TMS coils in realistic head geometry with an arbitrary overall coil shape...
July 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28457837/cost-effectiveness-of-deep-brain-stimulation-versus-treatment-as-usual-for-obsessive-compulsive-disorder
#20
Pieter Ooms, Matthijs Blankers, Martijn Figee, Isidoor O Bergfeld, Pepijn van den Munckhof, P Richard Schuurman, Damiaan Denys
BACKGROUND: Deep Brain Stimulation (DBS) is effective for obsessive-compulsive disorder (OCD), but requires expensive medical procedures. To date, no study has examined the cost-effectiveness of DBS for OCD. OBJECTIVE: To perform the first economic evaluation of DBS for therapy refractory OCD. METHODS: We conducted a 2-year prospective, open cost-effectiveness study, comparing DBS (n = 17) with treatment as usual (TAU) (n = 11), with cost per Quality-Adjusted-Life-Year (QALY) as outcome measure...
July 2017: Brain Stimulation
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