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Brain Stimulation

Francesca Bocca, Thomas Töllner, Hermann J Müller, Paul C Taylor
No abstract text is available yet for this article.
October 14, 2016: Brain Stimulation
Isabelle Beaulieu-Boire, Camila C Aquino, Alfonso Fasano, Yu-Yan Poon, Melanie Fallis, Antony E Lang, Mojgan Hodaie, Suneil K Kalia, Andres Lozano, Elena Moro
BACKGROUND: Rare causes of inherited movement disorders often present with a debilitating phenotype of dystonia, sometimes combined with parkinsonism and other neurological signs. Since these disorders are often resistant to medications, DBS may be considered as a possible treatment. METHODS: Patients with identified genetic diseases (ataxia-telangiectasia, chorea-achantocytosis, dopa-responsive dystonia, congenital nemaline myopathy, methylmalonic aciduria, neuronal ceroid lipofuscinosis, spinocerebellar ataxia types 2 and 3, Wilson's disease, Woodhouse-Sakati syndrome, methylmalonic aciduria, and X trisomy) and disabling dystonia underwent bilateral GPi DBS (bilateral thalamic Vim nucleus in 1 case)...
October 4, 2016: Brain Stimulation
Maria Concetta Pellicciari, Viviana Ponzo, Carlo Caltagirone, Giacomo Koch
No abstract text is available yet for this article.
September 26, 2016: Brain Stimulation
Koichiro Nakamura, Stefan Jun Groiss, Masashi Hamada, Hiroyuki Enomoto, Suguru Kadowaki, Mitsunari Abe, Takenobu Murakami, Winnugroho Wiratman, Fangyu Chang, Shunsuke Kobayashi, Ritsuko Hanajima, Yasuo Terao, Yoshikazu Ugawa
BACKGROUND: Responses to plasticity-inducing brain stimulation protocols are highly variable. However, no data are available concerning the variability of responses to quadripulse stimulation (QPS). OBJECTIVE: We assessed the QPS parameters of motor cortical plasticity induction in a systematic manner, and later investigated the variability of QPS using optimal parameters. METHODS: First, two different interburst intervals (IBI) with the same total number of pulses were compared...
September 21, 2016: Brain Stimulation
Juan Carlos Baldermann, Sina Kohl, Veerle Visser-Vandewalle, Martin Klehr, Daniel Huys, Jens Kuhn
No abstract text is available yet for this article.
September 13, 2016: Brain Stimulation
Molly Davis, Angela Phillips, Aron Tendler, Angela Oberdeck
No abstract text is available yet for this article.
September 13, 2016: Brain Stimulation
Bryan Howell, Cameron C McIntyre
BACKGROUND: Bioelectric field models of deep brain stimulation (DBS) are commonly utilized in research and industrial applications. However, the wide range of different representations used for the human head in these models may be responsible for substantial variance in the stimulation predictions. OBJECTIVE: Determine the relative error of ignoring cerebral vasculature and soft-tissue heterogeneity outside of the brain in computational models of DBS. METHODS: We used a detailed atlas of the human head, coupled to magnetic resonance imaging data, to construct a range of subthalamic DBS volume conductor models...
September 8, 2016: Brain Stimulation
Belen Lafon, Asif Rahman, Marom Bikson, Lucas C Parra
BACKGROUND: Direct current stimulation (DCS) affects both neuronal firing rate and synaptic efficacy. The neuronal input/output (I/O) function determines the likelihood that a neuron elicits an action potential in response to synaptic input of a given strength. Changes of the neuronal I/O function by DCS may underlie previous observations in animal models and human testing, yet have not been directly assessed. OBJECTIVE: Test if the neuronal input/output function is affected by DCS METHODS: Using rat hippocampal brain slices and computational modeling, we provide evidence for how DCS modulates the neuronal I/O function...
September 1, 2016: Brain Stimulation
Daniel San-Juan, Dulce Anabel Espinoza López, Rafael Vázquez Gregorio, Carlos Trenado, Maricarmen Fernández-González Aragón, León Morales-Quezada, Axel Hernandez Ruiz, Flavio Hernandez-González, Alejandro Alcaraz-Guzmán, David J Anschel, Felipe Fregni
BACKGROUND: Transcranial direct current stimulation (tDCS) has been evaluated in medication refractory epilepsy patients. The results have been inconclusive and protocols have varied between studies. OBJECTIVE: To evaluate the safety and efficacy of two protocols of tDCS in adult patients with mesial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS). METHODS: This is a randomized placebo-controlled, double-blinded clinical trial, with 3 arms, 3 sessions, 5 sessions and placebo stimulation...
August 31, 2016: Brain Stimulation
D Martínez-Vargas, A Valdés-Cruz, V M Magdaleno-Madrigal, R Fernández-Mas, S Almazán-Alvarado
BACKGROUND: The nucleus of the solitary tract (NTS) plays a determinant role in the antiepileptic effects of vagus nerve stimulation (VNS). One mechanism underlying the efficacy of VNS is the induction of cortical changes, detected by electroencephalogram (EEG), which can be mediated by the NTS through its projections to the cerebral nuclei responsible for modulating cortical activity. The effect of the electrical stimulation of the nucleus of the solitary tract (ENTS) on EEG activity and sleep states in freely moving animals is unknown...
August 26, 2016: Brain Stimulation
Tuo Lin, Lisheng Jiang, Zulin Dou, Cheng Wu, Feng Liu, Guangqing Xu, Yue Lan
BACKGROUND: Continuous theta burst stimulation (cTBS) and intermittent TBS (iTBS) are powerful patterns of repetitive transcranial magnetic stimulation (rTMS), with substantial potential for motor function rehabilitation post-stroke. However, TBS of suprahyoid motor cortex excitability has not been investigated. This study investigated TBS effects on suprahyoid motor cortex excitability and its potential mechanisms in healthy subjects. METHODS: Thirty-five healthy subjects (23 females; mean age = 21...
August 24, 2016: Brain Stimulation
Niels Allert, Marta Reyes Santana, Hans Karbe
No abstract text is available yet for this article.
August 20, 2016: Brain Stimulation
Pratik Y Chhatbar, James R Sawers, Wuwei Feng
No abstract text is available yet for this article.
August 16, 2016: Brain Stimulation
Min-Shan Li, Ying-Yeh Chen, Galen Chin-Lun Hung
No abstract text is available yet for this article.
August 15, 2016: Brain Stimulation
R F H Cash, G Jegatheeswaran, Z Ni, R Chen
BACKGROUND: The mechanisms mediating the efficacy and variability of paired associative stimulation (PAS), thought to be mediated by Hebbian plasticity, remain incompletely understood. The magnitude and direction of Hebbian plasticity may be modulated by the level of neural depolarisation, which is influenced by stimulation intensity and interactions with cortical circuits. HYPOTHESIS: PAS effects would be influenced by the intensity of transcranial magnetic stimulation (TMS) and interaction with other circuits...
August 12, 2016: Brain Stimulation
Eunhee Park, Min Su Kim, Won Hyuk Chang, Su Mi Oh, Yun Kwan Kim, Ahee Lee, Yun-Hee Kim
BACKGROUND: Optimal protocol of repetitive transcranial magnetic stimulation (rTMS) on post-stroke dysphagia remains uncertain with regard to its clinical efficacy. OBJECTIVE: The aim of the present study is to investigate the effects of high-frequency rTMS at the bilateral motor cortices over the cortical representation of the mylohyoid muscles in the patients with post-stroke dysphagia. METHODS: This study was a single-blind, randomized controlled study with a blinded observer...
August 11, 2016: Brain Stimulation
Oana M Dumitrascu, Jan Kamiński, Ueli Rutishauser, Michele Tagliati
No abstract text is available yet for this article.
August 11, 2016: Brain Stimulation
George M Opie, Nigel C Rogasch, Mitchell R Goldsworthy, Michael C Ridding, John G Semmler
BACKGROUND: Long-interval intracortical inhibition (LICI) is a transcranial magnetic stimulation (TMS) paradigm that uses paired magnetic stimuli separated by 100-200 ms to investigate the activity of cortical GABAergic interneurons. While commonly applied, the mechanisms contributing to LICI are not well understood, and growing evidence suggests that inhibition observed at different interstimulus intervals (ISI) may involve non-identical processes. OBJECTIVE: This study aims to utilise combined TMS-EEG to more thoroughly characterise LICI at different ISIs, as the TMS-evoked EEG potential (TEP) can provide more direct insight into the cortical response to stimulation that is not subject to variations in spinal cord excitability that can confound the motor evoked potential (MEP)...
August 8, 2016: Brain Stimulation
Jozarni J Dlabac-de Lange, Edith J Liemburg, Leonie Bais, Aida T van de Poel-Mustafayeva, Elly S M de Lange-de Klerk, Henderikus Knegtering, André Aleman
BACKGROUND: Prefrontal repetitive Transcranial Magnetic Stimulation (rTMS) may improve negative symptoms in patients with schizophrenia, but few studies have investigated the underlying neural mechanism. OBJECTIVE: This study aims to investigate changes in the levels of glutamate and glutamine (Glx, neurotransmitter and precursor) and N-Acetyl Aspartate (NAA) in the left dorsolateral prefrontal cortex of patients with schizophrenia treated with active bilateral prefrontal rTMS as compared to sham-rTMS, as measured with (1)H-Magnetic Resonance Spectroscopy ((1)H-MRS)...
August 5, 2016: Brain Stimulation
Bashar W Badran, Chloe E Glusman, Chris W Austelle, Shonna Jenkins, William H DeVries, Virginia Galbraith, Tiffani Thomas, Thomas G Adams, Mark S George, Gonzalo J Revuelta
No abstract text is available yet for this article.
August 5, 2016: Brain Stimulation
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