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Brain Stimulation

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https://www.readbyqxmd.com/read/29331287/characterizing-the-effects-of-deep-brain-stimulation-with-magnetoencephalography-a-review
#1
REVIEW
Irene E Harmsen, Nathan C Rowland, Richard A Wennberg, Andres M Lozano
BACKGROUND: Deep brain stimulation (DBS) is an important form of neuromodulation that is being applied to patients with motor, mood, or cognitive circuit disorders. Despite the efficacy and widespread use of DBS, the precise mechanisms by which it works remain unknown. Over the last decade, magnetoencephalography (MEG) has become an important functional neuroimaging technique used to study DBS. OBJECTIVE: This review summarizes the literature related to the use of MEG to characterize the effects of DBS...
January 4, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29330020/predictors-of-deep-brain-stimulation-outcome-in-tremor-patients
#2
Claire Sandoe, Vibhor Krishna, Diellor Basha, Francesco Sammartino, Joao Tatsch, Marina Picillo, Lazzaro di Biase, Yu-Yan Poon, Clement Hamani, Duemani Reddy, Renato P Munhoz, Andres M Lozano, William D Hutchison, Alfonso Fasano
BACKGROUND: Deep brain stimulation of the ventro-intermedius nucleus of the thalamus is an established treatment for tremor of differing etiologies but factors that may predict the short- and especially long-term outcome of surgery are still largely unknown. METHODS: We retrospectively investigated the clinical, pharmacological, electrophysiological and anatomical features that might predict the initial response and preservation of benefit in all patients who underwent deep brain stimulation for tremor...
January 2, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29317185/cortical-inhibition-assessed-using-paired-pulse-tms-eeg-is-increased-in-older-adults
#3
George M Opie, Simranjit K Sidhu, Nigel C Rogasch, Michael C Ridding, John G Semmler
BACKGROUND: Alterations in inhibitory processes mediated by gamma-aminobutyric acid type B (GABAB) receptors may contribute to age-related functional impairments. However, investigation of these circuits using conventional paired-pulse transcranial magnetic stimulation (TMS) at long interstimulus intervals (∼100-200ms) have produced conflicting results in older adults, possibly due to the indirect nature of the TMS motor evoked potential (MEP). OBJECTIVE: To utilise electroencephalography and TMS coregistration (TMS-EEG) to more directly assess age-related changes in GABAB-mediated long-interval intracortical inhibition (LICI)...
December 30, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29326021/similar-clinical-improvement-and-maintenance-after-rtms-at-5-hz-using-a-simple-vs-complex-protocol-in-alzheimer-s-disease
#4
LETTER
R Alcalá-Lozano, E Morelos-Santana, J F Cortés-Sotres, E A Garza-Villarreal, A L Sosa-Ortiz, J J González-Olvera
BRACKGROUND: Current treatments for Alzheimer's disease (AD) have a limited clinical response and methods, such as repetitive transcranial magnetic stimulation (rTMS), are being studied as possible treatments for the clinical symptoms with positive results. However, there is still seldom information on the type of rTMS protocols that deliver the best clinical improvement in AD. Objetive: To compare the clinical response between a simple stimulation protocol on the left dorsolateral prefrontal cortex (lDLPFC) against a complex protocol using six regions of interest...
December 29, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29311014/thirst-induced-by-low-frequency-right-hemisphere-focal-rtms
#5
LETTER
Mélanie Cogné, Jérome Aupy, Cédric Gil-Jardiné, Bertrand Glize
No abstract text is available yet for this article.
December 29, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29317186/perturbation-of-theta-gamma-coupling-at-the-temporal-lobe-hinders-verbal-declarative-memory
#6
Gabriel Amador de Lara, Ivan Alekseichuk, Zsolt Turi, Albert Lehr, Andrea Antal, Walter Paulus
BACKGROUND: Phase-amplitude cross-frequency coupling (PAC) is characterized by the modulation of the power of a fast brain oscillation (e.g., gamma) by the phase of a slow rhythm (e.g., theta). PAC in different sub- and neocortical regions is known to underlie effective neural communication and correlates with successful long-term memory formation. OBJECTIVE/HYPOTHESIS: The present work aims to extend earlier observational data, by probing the functional role of theta-gamma PAC in the left temporal cortex in humans during verbal long-term memory encoding...
December 25, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29307610/early-use-of-80-hz-subthalamic-stimulation-in-parkinson-s-disease-as-an-alternative-for-high-frequency-stimulation-induced-gait-changes-and-postural-instability
#7
LETTER
Marcelo D Mendonça, Raquel Barbosa, Alexandra Seromenho-Santos, Carla Reizinho, Paulo Bugalho
No abstract text is available yet for this article.
December 20, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29289565/artifactual-hyperpolarization-during-extracellular-electrical-stimulation-proposed-mechanism-of-high-rate-neuromodulation-disproved
#8
L Stephen Lesperance, Milad Lankarany, Tianhe C Zhang, Rosana Esteller, Stéphanie Ratté, Steven A Prescott
BACKGROUND: Kilohertz-frequency electric field stimulation (kEFS) applied to the spinal cord can reduce chronic pain without causing the buzzing sensation (paresthesia) associated with activation of dorsal column fibers. This suggests that high-rate spinal cord stimulation (SCS) has a mode of action distinct from conventional, parasthesia-based SCS. A recent study reported that kEFS hyperpolarizes spinal neurons, yet this potentially transformative mode of action contradicts previous evidence that kEFS induces depolarization and was based on patch clamp recordings whose accuracy in the presence of kEFS has not been verified...
December 15, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29258807/the-intensity-of-continuous-theta-burst-stimulation-but-not-the-waveform-used-to-elicit-motor-evoked-potentials-influences-its-outcome-in-the-human-motor-cortex
#9
Takuya Sasaki, Satoshi Kodama, Naohiko Togashi, Yuichiro Shirota, Yusuke Sugiyama, Shin-Ichi Tokushige, Satomi Inomata-Terada, Yasuo Terao, Yoshikazu Ugawa, Masashi Hamada
BACKGROUND: Responses to continuous theta burst stimulation (cTBS) applied to the human primary motor cortex are highly variable between individuals. However, little is known about how to improve the after-effects of cTBS by adjusting the protocol characteristics. OBJECTIVE: We examined whether current directions adopted in the measurement of cortical motor excitability indexed as motor evoked potentials (MEPs) affect the responses to cTBS. We also tested whether the stimulus intensity of cTBS influences the after-effects...
December 15, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29258808/incomplete-evidence-that-increasing-current-intensity-of-tdcs-boosts-outcomes
#10
Zeinab Esmaeilpour, Paola Marangolo, Benjamin M Hampstead, Sven Bestmann, Elisabeth Galletta, Helena Knotkova, Marom Bikson
BACKGROUND: Transcranial direct current stimulation (tDCS) is investigated to modulate neuronal function by applying a fixed low-intensity direct current to scalp. OBJECTIVES: We critically discuss evidence for a monotonic response in effect size with increasing current intensity, with a specific focus on a question if increasing applied current enhance the efficacy of tDCS. METHODS: We analyzed tDCS intensity does-response from different perspectives including biophysical modeling, animal modeling, human neurophysiology, neuroimaging and behavioral/clinical measures...
December 13, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29246748/impact-of-brain-shift-on-subcallosal-cingulate-deep-brain-stimulation
#11
Ki Sueng Choi, Angela M Noecker, Patricio Riva-Posse, Justin K Rajendra, Robert E Gross, Helen S Mayberg, Cameron C McIntyre
BACKGROUND: Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) is an emerging experimental therapy for treatment-resistant depression. New developments in SCC DBS surgical targeting are focused on identifying specific axonal pathways for stimulation that are estimated from preoperatively collected diffusion-weighted imaging (DWI) data. However, brain shift induced by opening burr holes in the skull may alter the position of the target pathways. OBJECTIVES: Quantify the effect of electrode location deviations on tractographic representations for stimulating the target pathways using longitudinal clinical imaging datasets...
December 6, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29326022/the-effects-of-repetitive-transcranial-magnetic-stimulation-on-eating-behaviors-and-body-weight-in-obesity-a-randomized-controlled-study
#12
Se-Hong Kim, Ju-Hye Chung, Tae-Hong Kim, Seong Hoon Lim, Youngkook Kim, Yun-Ah Lee, Sang-Wook Song
BACKGROUND: Although some studies have reported significant reductions in food cravings following repetitive transcranial magnetic stimulation (rTMS), none have examined changes in body weight. OBJECTIVE: We conducted 2-week randomized, sham-controlled, single-blind, parallel-group trial to examine the effect of rTMS on body weight in obese patients. METHODS: Sixty obese patients (body mass index [BMI] ≥25 kg/m2) aged between 18 and 65 years were recruited...
December 1, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29246747/tms-over-posterior-parietal-cortex-disrupts-trans-saccadic-visual-stability
#13
Thérèse Collins, Pierre O Jacquet
BACKGROUND: Saccadic eye movements change the retinal location of visual objects, but we do not experience the visual world as constantly moving, we perceive it as seamless and stable. This visual stability may be achieved by an internal or efference copy of each saccade that, combined with the retinal information, allows the visual system to cancel out or ignore the self-caused retinal motion. OBJECTIVE: The current study investigated the underlying brain mechanisms responsible for visual stability in humans with online transcranial magnetic stimulation (TMS)...
November 29, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29221910/motor-cortex-transcranial-direct-current-stimulation-tdcs-improves-acute-stroke-visuo-spatial-neglect-a-series-of-four-case-reports
#14
LETTER
S Bornheim, P Maquet, J L Croisier, J M Crielaard, J F Kaux
No abstract text is available yet for this article.
November 29, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29203131/electroconvulsive-therapy-and-subsequent-epilepsy-in-patients-with-affective-disorders-a-register-based-danish-cohort-study
#15
Fie Krossdal Bøg, Martin Balslev Jørgensen, Zorana Jovanovic Andersen, Merete Osler
OBJECTIVE: It has been suggested that Electroconvulsive Therapy (ECT) might increase the risk of epilepsy but the few patient studies with retrospective data from medical records do not support the hypothesis. The aim of this study was to examine the relationship between ECT and subsequent incident epilepsy in patients with affective disorder. We also explored whether any association varied with number of ECTs and time since last treatment. METHODS: All 169,457 patients with first hospital contact for an affective disorder between January 2005 and December 2015 were identified in the Danish National Patient Registry and followed for incident epilepsy from January 2005 until November 2016...
November 26, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29191438/real-time-eeg-defined-excitability-states-determine-efficacy-of-tms-induced-plasticity-in-human-motor-cortex
#16
Christoph Zrenner, Debora Desideri, Paolo Belardinelli, Ulf Ziemann
BACKGROUND: Rapidly changing excitability states in an oscillating neuronal network can explain response variability to external stimulation, but if repetitive stimulation of always the same high- or low-excitability state results in long-term plasticity of opposite direction has never been explored in vivo. OBJECTIVE/HYPOTHESIS: Different phases of the endogenous sensorimotor μ-rhythm represent different states of corticospinal excitability, and repetitive transcranial magnetic stimulation (rTMS) of always the same high- vs...
November 24, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29246746/chronic-deep-brain-stimulation-in-an-alzheimer-s-disease-mouse-model-enhances-memory-and-reduces-pathological-hallmarks
#17
Amandeep Mann, Elise Gondard, Davide Tampellini, Jorge A T Milsted, Desiree Marillac, Clement Hamani, Suneil K Kalia, Andres M Lozano
BACKGROUND: Alzheimer's disease (AD) is a progressive degenerative disorder that currently remains extremely disabling. Recent work has shown that deep brain stimulation (DBS) has promising effects in AD patients. In parallel to the clinical trials, we investigated the impact of chronic DBS in 3xTg mice, a well-established animal model of AD. METHODS: AD mice were assigned to control (Cont), non-stimulation (NS) and stimulation (DBS) groups, along with age matched wild type controls (WT-Cont)...
November 23, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29203130/a-pilot-study-of-subthalamic-theta-frequency-deep-brain-stimulation-for-cognitive-dysfunction-in-parkinson-s-disease
#18
LETTER
Katherine W Scangos, Cameron S Carter, Gene Gurkoff, Lin Zhang, Kiarash Shahlaie
No abstract text is available yet for this article.
November 23, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29191439/effects-of-cerebellar-neuromodulation-in-movement-disorders-a%C3%A2-systematic-review
#19
REVIEW
Carina França, Daniel Ciampi de Andrade, Manoel Jacobsen Teixeira, Ricardo Galhardoni, Valquiria Silva, Egberto Reis Barbosa, Rubens Gisbert Cury
BACKGROUND: The cerebellum is involved in the pathophysiology of many movement disorders and its importance in the field of neuromodulation is growing. OBJECTIVES: To review the current evidence for cerebellar modulation in movement disorders and its safety profile. METHODS: Eligible studies were identified after a systematic literature review of the effects of cerebellar modulation in cerebellar ataxia, Parkinson's disease (PD), essential tremor (ET), dystonia and progressive supranuclear palsy (PSP)...
November 23, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29195744/discrimination-of-atypical-parkinsonisms-with-transcranial-magnetic-stimulation
#20
Alberto Benussi, Valentina Dell'Era, Valentina Cantoni, Clarissa Ferrari, Salvatore Caratozzolo, Luca Rozzini, Antonella Alberici, Alessandro Padovani, Barbara Borroni
BACKGROUND: Differential diagnosis of atypical parkinsonian disorders, i.e. dementia with Lewy bodies (DLB), progressive supranuclear palsy (PSP) or corticobasal syndrome (CBS) still remains problematic. Furthermore, DLB may overlap with Alzheimer's disease (AD) in the early stages of disease. OBJECTIVE: To determine whether transcranial magnetic stimulation (TMS) can be used to classify atypical parkinsonian disorders and AD. METHODS: A paired-pulse TMS multi-paradigm approach assessing multiple intracortical circuits, as short interval intracortical inhibition-facilitation and short latency afferent inhibition, was used to model a decision tree analysis and determine diagnostic accuracy in classifying different neurodegenerative disorders...
November 22, 2017: Brain Stimulation
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