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Brain Stimulation

George M Opie, Eleni Vosnakis, Michael C Ridding, Ulf Ziemann, John G Semmler
BACKGROUND: Primary motor cortex (M1) neuroplasticity is reduced in old adults, which may contribute to the motor deficits commonly observed in the elderly. Previous research in young subjects suggests that the neuroplastic response can be enhanced using non-invasive brain stimulation (NIBS), with a larger plastic response observed following priming with both long-term potentiation (LTP) and depression (LTD)-like protocols. However, it is not known if priming stimulation can also modulate plasticity in older adults...
November 17, 2016: Brain Stimulation
Xiaoming Du, Peter Kochunov, Ann Summerfelt, Joshua Chiappelli, Fow-Sen Choa, L Elliot Hong
BACKGROUND: Inhibitory-excitatory (I-E) imbalance has increasingly been proposed as a fundamental mechanism giving rise to many schizophrenia-related pathophysiology. The integrity of I-E functions should require precise and rapid electrical signal transmission. OBJECTIVE/HYPOTHESIS: We hypothesized that part of the I-E abnormality in schizophrenia may originate from their known abnormal white matter connectivity that may interfere the I-E functions. METHODS: We test this using short-interval intracortical inhibition (SICI) vs...
November 12, 2016: Brain Stimulation
Michael J Carter, Dana Maslovat, Anthony N Carlsen
No abstract text is available yet for this article.
November 4, 2016: Brain Stimulation
Alberto Benussi, Valentina Dell'Era, Maria Sofia Cotelli, Marinella Turla, Carlo Casali, Alessandro Padovani, Barbara Borroni
BACKGROUND: Neurodegenerative cerebellar ataxias represent a group of disabling disorders for which we currently lack effective therapies. Cerebellar transcranial direct current stimulation (tDCS) is a non-invasive technique, which has been demonstrated to modulate cerebellar excitability and improve symptoms in patients with cerebellar ataxias. OBJECTIVE: The present study investigated whether a two-weeks' treatment with cerebellar anodal tDCS could improve symptoms in patients with neurodegenerative cerebellar ataxia and could modulate cerebello-motor connectivity, at short and long term...
November 3, 2016: Brain Stimulation
Elizabeth F Chua, Rifat Ahmed, Sandry M Garcia
BACKGROUND: The ability to monitor one's own memory is an important feature of normal memory and is an aspect of 'metamemory'. Lesion studies have shown dissociations between memory and metamemory, but only single dissociations have been shown using transcranial direct current stimulation (tDCS). One potential reason that only single dissociations have been shown is that tDCS effects may be moderated by task difficulty. OBJECTIVE/HYPOTHESIS: We used high definition (HD) tDCS to test for dissociable roles of the dorsolateral prefrontal cortex (DLPFC) and anterior temporal lobe (ATL) in semantic long-term memory and metamemory tasks...
November 1, 2016: Brain Stimulation
Rasmus Schülke, Benjamin Straube
BACKGROUND: Co-verbal gestures are crucial for communication. Neuroimaging studies suggest that the left frontal lobe may be especially important for processing metaphoric co-verbal gestures. However, so far, the specific functional relevance of the left frontal lobe in metaphoric (abstract sentence content) co-verbal gesture processing compared to iconic (concrete sentence content) co-verbal gesture processing has not been demonstrated. OBJECTIVE: We investigated the functional relevance of the left frontal lobe for processing metaphoric co-verbal gestures using transcranial direct current stimulation (tDCS)...
October 25, 2016: Brain Stimulation
Lorella Battelli, Emily D Grossman, Ela B Plow
BACKGROUND: The interhemispheric competition hypothesis attributes the distribution of selective attention to a balance of mutual inhibition between homotopic, interhemispheric connections in parietal cortex (Kinsbourne 1977; Battelli et al., 2009). In support of this hypothesis, repetitive inhibitory TMS over right parietal cortex in healthy individuals rapidly induces interhemispheric imbalance in cortical activity that spreads beyond the site of stimulation (Plow et al., 2014). Behaviorally, the impacts of inhibitory rTMS may be long delayed from the onset of stimulation, as much as 30 minutes (Agosta et al...
October 19, 2016: Brain Stimulation
Seo Young Gu, Min Cheol Chang
BACKGROUND: Half of all stroke patients experience depression, which adversely affects functional recovery. To improve functional outcomes, post-stroke depressive symptoms require more effective management strategies. OBJECTIVE: This study examined whether repetitive transcranial magnetic stimulation (rTMS) applied over the left dorsolateral prefrontal cortex (DLPFC) can manage post-stroke depression and improve motor function. METHODS: This study was a single-center, prospective, double blind, sham-controlled preliminary study...
October 18, 2016: Brain Stimulation
Bashar W Badran, Chris W Austelle, Nicole R Smith, Chloe E Glusman, Brett Froeliger, Eric L Garland, Jeffrey J Borckardt, Mark S George, Baron Short
No abstract text is available yet for this article.
October 17, 2016: Brain Stimulation
Kate Hoy
No abstract text is available yet for this article.
October 17, 2016: Brain Stimulation
Paul C Taylor, Gregor Thut
No abstract text is available yet for this article.
October 17, 2016: Brain Stimulation
Francesca Bocca, Thomas Töllner, Hermann J Müller, Paul C Taylor
No abstract text is available yet for this article.
October 14, 2016: Brain Stimulation
Abirami Muralidharan, Jianyu Zhang, Debabrata Ghosh, Mathew D Johnson, Kenneth B Baker, Jerrold L Vitek
BACKGROUND: The motor thalamus is a key nodal point in the pallidothalamocortical "motor" circuit, which has been implicated in the pathogenesis of Parkinson's disease (PD) and other movement disorders. Although a critical structure in the motor circuit, the role of the motor thalamus in mediating the therapeutic effects of deep brain stimulation (DBS) of the internal segment of the globus pallidus (GPi) is not fully understood. OBJECTIVE: To characterize the changes in neuronal activity in the pallidal (ventralis lateralis pars oralis (VLo) and ventralis anterior (VA)) and cerebellar (ventralis posterior lateralis pars oralis (VPLo)) receiving areas of the motor thalamus during therapeutic GPi DBS...
October 11, 2016: Brain Stimulation
Elisabeth Hartl, Berend Feddersen, Kai Bötzel, Jan-Hinnerk Mehrkens, Soheyl Noachtar
No abstract text is available yet for this article.
October 6, 2016: Brain Stimulation
Isabelle Beaulieu-Boire, Camila C Aquino, Alfonso Fasano, Yu-Yan Poon, Melanie Fallis, Antony E Lang, Mojgan Hodaie, Suneil K Kalia, Andres Lozano, Elena Moro
BACKGROUND: Rare causes of inherited movement disorders often present with a debilitating phenotype of dystonia, sometimes combined with parkinsonism and other neurological signs. Since these disorders are often resistant to medications, DBS may be considered as a possible treatment. METHODS: Patients with identified genetic diseases (ataxia-telangiectasia, chorea-achantocytosis, dopa-responsive dystonia, congenital nemaline myopathy, methylmalonic aciduria, neuronal ceroid lipofuscinosis, spinocerebellar ataxia types 2 and 3, Wilson's disease, Woodhouse-Sakati syndrome, methylmalonic aciduria, and X trisomy) and disabling dystonia underwent bilateral GPi DBS (bilateral thalamic Vim nucleus in 1 case)...
October 4, 2016: Brain Stimulation
Maria Concetta Pellicciari, Viviana Ponzo, Carlo Caltagirone, Giacomo Koch
No abstract text is available yet for this article.
September 26, 2016: Brain Stimulation
Koichiro Nakamura, Stefan Jun Groiss, Masashi Hamada, Hiroyuki Enomoto, Suguru Kadowaki, Mitsunari Abe, Takenobu Murakami, Winnugroho Wiratman, Fangyu Chang, Shunsuke Kobayashi, Ritsuko Hanajima, Yasuo Terao, Yoshikazu Ugawa
BACKGROUND: Responses to plasticity-inducing brain stimulation protocols are highly variable. However, no data are available concerning the variability of responses to quadripulse stimulation (QPS). OBJECTIVE: We assessed the QPS parameters of motor cortical plasticity induction in a systematic manner, and later investigated the variability of QPS using optimal parameters. METHODS: First, two different interburst intervals (IBI) with the same total number of pulses were compared...
September 21, 2016: Brain Stimulation
Juan Carlos Baldermann, Sina Kohl, Veerle Visser-Vandewalle, Martin Klehr, Daniel Huys, Jens Kuhn
No abstract text is available yet for this article.
September 13, 2016: Brain Stimulation
Molly Davis, Angela Phillips, Aron Tendler, Angela Oberdeck
No abstract text is available yet for this article.
September 13, 2016: Brain Stimulation
Bryan Howell, Cameron C McIntyre
BACKGROUND: Bioelectric field models of deep brain stimulation (DBS) are commonly utilized in research and industrial applications. However, the wide range of different representations used for the human head in these models may be responsible for substantial variance in the stimulation predictions. OBJECTIVE: Determine the relative error of ignoring cerebral vasculature and soft-tissue heterogeneity outside of the brain in computational models of DBS. METHODS: We used a detailed atlas of the human head, coupled to magnetic resonance imaging data, to construct a range of subthalamic DBS volume conductor models...
September 8, 2016: Brain Stimulation
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