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Brain Stimulation

Zhen Ni, Robin F H Cash, Carolyn Gunraj, Eduard Bercovici, Mark Hallett, Robert Chen
BACKGROUND: Paired associative stimulation (PAS), with stimulus interval of 21.5 or 25 ms, using transcranial magnetic stimulation in the posterior-anterior (PA) current direction, produces a long-term-potentiation-like effect. Stimulation with PA directed current generates both early and late indirect (I)-waves while that in anterior-posterior (AP) current predominantly elicits late I-waves. Short interval intracortical inhibition (SICI) inhibits late I-waves but not early I-waves...
September 5, 2018: Brain Stimulation
Olivier Bodart, Matteo Fecchio, Marcello Massimini, Sarah Wannez, Alessandra Virgillito, Silvia Casarotto, Mario Rosanova, Antoine Lutz, Matthieu Ricard, Steven Laureys, Olivia Gosseries
No abstract text is available yet for this article.
September 1, 2018: Brain Stimulation
Ramajayam Govindaraj, Urvakhsh Meherwan Mehta, Vinod Kumar, Shivarama Varambally, Jagadisha Thirthalli, Bangalore N Gangadhar
No abstract text is available yet for this article.
August 29, 2018: Brain Stimulation
Shirley Sharabi, Dianne Daniels, David Last, David Guez, Zion Zivli, David Castel, Yoav Levy, Alexander Volovick, Javier Grinfeld, Itay Rachmilevich, Talia Amar, Yael Mardor, Sagi Harnof
BACKGROUND: Essential tremor (ET) is one of the most common movement disorders of adults, characterized by postural and kinetic tremor. With drug treatment only partially efficient, new treatments are being developed. OBJECTIVES: The goal of this study was to demonstrate the feasibility of non-thermal focused-ultrasound (FUS) to induce tremor-suppression in an ET rat model. METHODS: Harmaline-induced tremor rats were treated with FUS along the inferior olivary (IO) system...
August 27, 2018: Brain Stimulation
Chuyi Huang, Heling Chu, Yu Ma, Zaiying Zhou, Chuanfu Dai, Xiaowen Huang, Liang Fang, Qiang Ao, Dongya Huang
BACKGROUND: Alzheimer's disease (AD) is the most common type of dementia and mainly treated by drugs, while the therapeutic outcomes are very limited. This study aimed to determine the optimized parameters of deep brain stimulation (DBS) which was applied to the treatment of AD and propose the involved mechanisms. METHODS: Amyloid-β precursor protein/Presenilin1 (APP/PS1) transgenic mice were used and received DBS at nucleus basalis of Meynert (NBM). The optimized parameters of DBS were determined by using different stimulation frequencies, durations and ages of mice under Morris water maze test...
August 27, 2018: Brain Stimulation
Michael T Barbe, Claudia Barthel, Lilly Chen, Nic Van Dyck, Thomas Brücke, Fernando Seijo, Esther Suarez San Martin, Claire Haegelen, Marc Verin, Martin Amarell, Steve Gill, Alan Whone, Mauro Porta, Domenico Servello, Gereon R Fink, François Alesch, Bastiaan R Bloem, Lars Timmermann
No abstract text is available yet for this article.
August 27, 2018: Brain Stimulation
Gavin J B Elias, Andres M Lozano
No abstract text is available yet for this article.
August 24, 2018: Brain Stimulation
J Redgrave, D Day, H Leung, P J Laud, A Ali, R Lindert, A Majid
BACKGROUND: Transcutaneous Vagus Nerve stimulation (tVNS) may be an alternative to surgically implanted VNS for epilepsy and other diseases. However, its safety and tolerability profile is unclear. OBJECTIVE: We performed a systematic review of treatment harms from tVNS in humans. METHODS: A systematic published and grey literature search was carried out to identify studies which deployed tVNS in human subjects. Study authors were contacted for safety/tolerability data if these were not available in the publication...
August 23, 2018: Brain Stimulation
Donel M Martin, Shawn M McClintock, Scott T Aaronson, Angelo Alonzo, Mustafa M Husain, Sarah H Lisanby, William M McDonald, Adith Mohan, Stevan Nikolin, John O'Reardon, Cynthia Shannon Weickert, Colleen K Loo
BACKGROUND: Transcranial direct current stimulation (tDCS) has promising antidepressant effects, however, clinical trials have shown variable efficacy. Pre-treatment neurocognitive functioning has previously been identified as an inter-individual predictor of tDCS antidepressant efficacy. OBJECTIVE: In this international multicentre, sham-controlled study, we investigated this relationship while also assessing the influence of clinical and genotype (BDNF Val66Met and COMT Val158Met polymorphisms) factors as predictors of response to active tDCS...
August 23, 2018: Brain Stimulation
Anton Fomenko, Clemens Neudorfer, Robert F Dallapiazza, Suneil K Kalia, Andres M Lozano
BACKGROUND: There is an emerging need for noninvasive neuromodulation techniques to improve patient outcomes while minimizing adverse events and morbidity. Low-intensity focused ultrasound (LIFUS) is gaining traction as a non-surgical experimental approach of modulating brain activity. Several LIFUS sonication parameters have been found to potentiate neural firing, suppress cortical and epileptic discharges, and alter behavior when delivered to cortical and subcortical mammalian brain regions...
August 23, 2018: Brain Stimulation
Robert Guggenberger, Dominic Kraus, Georgios Naros, Maria Teresa Leão, Ulf Ziemann, Alireza Gharabaghi
BACKGROUND: Pairing cortical and peripheral input during motor imagery (MI)-related sensorimotor desynchronization (ERD) modulates corticospinal excitability at the cortical representation (hotspot) of the imagined movement. OBJECTIVE: To determine the effects of this associative stimulation protocol on the cortical motor map beyond the hotspot. METHODS: In healthy subjects, peripheral stimulation through passive hand opening by a robotic orthosis and single-pulse transcranial magnetic stimulation to the respective cortical motor representation were applied in a brain-machine interface environment...
August 22, 2018: Brain Stimulation
Julius Fridriksson, Jordan Elm, Brielle C Stark, Alexandra Basilakos, Chris Rorden, Souvik Sen, Mark S George, Michelle Gottfried, Leonardo Bonilha
BACKGROUND: Several studies, including a randomized controlled trial by our group, support applying anodal tDCS (A-tDCS) to the left hemisphere during behavioral aphasia treatment to improve outcomes. A clear mechanism explaining A-tDCS's efficacy has not been established, but modulation of neuroplasticity may be involved. OBJECTIVE/HYPOTHESIS: The brain-derived neurotrophic factor (BDNF) gene influences neuroplasticity and may modulate the effects of tDCS. Utilizing data from our recently completed trial, we conducted a planned test of whether aphasia treatment outcome is influenced by interaction between A-tDCS and a single-nucleotide polymorphism of the BDNF gene, rs6265...
August 18, 2018: Brain Stimulation
Katherine Dyke, Soyoung Kim, Georgina M Jackson, Stephen R Jackson
No abstract text is available yet for this article.
August 18, 2018: Brain Stimulation
F Proessl, B Poston, T Rudroff
No abstract text is available yet for this article.
August 17, 2018: Brain Stimulation
Philippe De Vloo, Robert F Dallapiazza, Darrin J Lee, Mateusz Zurowski, Philip W Peng, Robert Chen, Mojgan Hodaie
No abstract text is available yet for this article.
August 16, 2018: Brain Stimulation
Saxby Pridmore, Tamara May
BACKGROUND: TMS is safe and effective in the treatment of MDD, but as with other treatments, relapse may occur on cessation of treatment. OBJECTIVE: To prevent relapse in MDD, following successful acute TMS treatment. METHOD: 5 TMS treatments over 3 days, repeated at about monthly intervals. RESULTS: 14 patients received this care for more than 12 months. At the commencement of each series the mood scores were close to relapse, but at completion they were in the remitted range...
August 16, 2018: Brain Stimulation
Pedro Caldana Gordon, Debora Desideri, Paolo Belardinelli, Christoph Zrenner, Ulf Ziemann
BACKGROUND: The analysis of cortical responses to transcranial magnetic stimulation (TMS) recorded by electroencephalography (EEG) has been successfully applied to study human cortical physiology. However, in addition to the (desired) activation of cortical neurons and fibers, TMS also causes (undesired) indirect brain responses through auditory and somatosensory stimulation, which may contribute significantly to the overall EEG signal and mask the effects of intervention on direct cortical responses...
August 16, 2018: Brain Stimulation
Julie Jonckheere, Jean-Christophe Deloulme, Gaëlle Dall'Igna, Nicolas Chauliac, Albane Pelluet, Anne-Sophie Nguon, Celia Lentini, Jacques Brocard, Eric Denarier, Sabine Brugière, Yohann Couté, Christophe Heinrich, Christophe Porcher, Jérôme Holtzmann, Annie Andrieux, Marie-Françoise Suaud-Chagny, Sylvie Gory-Fauré
BACKGROUND: Severe and medication-resistant psychiatric diseases, such as major depressive disorder, bipolar disorder or schizophrenia, can be effectively and rapidly treated by electroconvulsive therapy (ECT). Despite extensive long-standing clinical use, the neurobiological mechanisms underlying the curative action of ECT remain incompletely understood. OBJECTIVE: Unravel biological basis of electroconvulsive stimulation (ECS) efficacy, the animal equivalent of ECT...
August 15, 2018: Brain Stimulation
Min Wu, Yuehao Wu, Yamei Yu, Jian Gao, Fanxia Meng, Fangping He, Jianfei Shi, Benyan Luo
No abstract text is available yet for this article.
August 1, 2018: Brain Stimulation
Takuya Sasaki, Yuichiro Shirota, Satoshi Kodama, Naohiko Togashi, Yusuke Sugiyama, Shin-Ichi Tokushige, Satomi Inomata-Terada, Yasuo Terao, Yoshikazu Ugawa, Tatsushi Toda, Masashi Hamada
BACKGROUND: Paired associative stimulation (PAS) induces long-term potentiation (LTP)-like effects when interstimulus intervals (ISIs) between electrical peripheral nerve stimulation and transcranial magnetic stimulation (TMS) to M1 are approximately 21-25 ms (PASLTP ). It was previously reported that two forms of motor learning (i.e., mode-free and model-based learning) can be differentially modulated by PASLTP depending on the different synaptic inputs to corticospinal neurons (CSNs), which relate to posterior-to-anterior (PA) or anterior-to-posterior (AP) currents induced by TMS (PA or AP inputs, respectively)...
July 31, 2018: Brain Stimulation
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