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Archives of Cardiovascular Diseases

Mariana Mirabel, Matthias Lachaud, Lucile Offredo, Cécile Lachaud, Benjamin Zuschmidt, Beatriz Ferreira, Daniel Sidi, Sylvain Chauvaud, Phang Sok, Alain Deloche, Eloi Marijon, Xavier Jouven
BACKGROUND: Access to cardiac surgery is limited in low-income settings, and data on patient outcomes are scarce. AIMS: To assess characteristics, surgical procedures and outcomes in patients undergoing open-heart surgery in low-income settings. METHODS: This was a cohort study (2001-2011) in two low-income countries, Cambodia and Mozambique, where cardiac surgery had been promoted by visiting non-governmental organizations. RESULTS: In Cambodia and Mozambique, respectively, 1332 and 767 consecutive patients were included; 547 (41...
October 3, 2016: Archives of Cardiovascular Diseases
Laura Cluzol, Jennifer Cautela, Pierre Michelet, Antoine Roch, François Kerbaul, Julien Mancini, Marc Laine, Michael Peyrol, Floriane Robin, Franck Paganelli, Laurent Bonello, Franck Thuny
BACKGROUND: Acute heart failure (AHF) is a life-threatening medical emergency for which no new effective therapies have emerged in recent decades. No previous study has exhaustively described the entire course of care of AHF patients from first medical contact to hospital discharge or assessed its impact on prognosis. AIM: To fully describe the course of care and analyze its influence on outcomes in patients hospitalized with an AHF syndrome in an academic university center...
September 29, 2016: Archives of Cardiovascular Diseases
Meyer Elbaz, Julien Faccini, Vanina Bongard, Cécile Ingueneau, Dorotea Taraszkiewicz, Bertrand Perret, Jean Ferrières, Jean-Bernard Ruidavets, Cécile Vindis
BACKGROUND: High-density lipoproteins (HDLs) are highly heterogeneous particles, and the specific contribution of each subclass to the prediction of clinical outcome in coronary artery disease (CAD) remains controversial. OBJECTIVE: To examine the relationship between HDL subclass profile and mortality in patients with CAD, using a new and rapid electrophoretic quantitative method for the assessment of HDL particle size phenotype. METHODS: We investigated 403 patients with CAD admitted for cardiovascular examination in the context of evaluation and management of CAD...
September 29, 2016: Archives of Cardiovascular Diseases
Dominique Stephan, Elena-Mihaela Cordeanu, Corina Mirea, Alix Faller, Anne Lejay, Sébastien Gaertner
Non-vitamin K antagonist oral anticoagulants are becoming increasingly important in the prophylaxis and treatment of thrombosis in atrial fibrillation and venous thromboembolism. Antiplatelets are widely prescribed in the primary and secondary prevention of cardiac and vascular diseases. There are potentially numerous situations where anticoagulants and antiplatelets may be combined; these combinations have been explored in coronary artery disease, and some have been included in updated recommendations. Is it legitimate to transpose these recommendations to the management of peripheral artery disease? The specific characteristics of the treated vessels, the stents used, the respective frequencies of stent thrombosis and its effect on the target organ are probably different, and explain why opinions differ...
September 28, 2016: Archives of Cardiovascular Diseases
Franck Levy, Laura Iacuzio, Filippo Civaia, Stephane Rusek, Carine Dommerc, Nicolas Hugues, Clara Alexandrescu, Vincent Dor, Christophe Tribouilloy, Gilles Dreyfus
BACKGROUND: Recently, 1.5-Tesla cardiac magnetic resonance imaging (CMR) was reported to provide a reliable alternative to transthoracic echocardiography (TTE) for the quantification of aortic stenosis (AS) severity. Few data are available using higher magnetic field strength MRI systems in this context. AIMS: To evaluate the feasibility and reproducibility of the assessment of aortic valve area (AVA) using 3-Tesla CMR in routine clinical practice, and to assess concordance between TTE and CMR for the estimation of AS severity...
September 28, 2016: Archives of Cardiovascular Diseases
Matthias Kohlhauer, Alain Berdeaux, Bijan Ghaleh, Renaud Tissier
The cardioprotective effect of therapeutic hypothermia (32-34°C) has been well demonstrated in animal models of acute myocardial infarction. Beyond infarct size reduction, this protection was associated with prevention of the no-reflow phenomenon and long-term improvement in terms of left ventricular remodelling and performance. However, all these events were observed when hypothermia was induced during the ischaemic episode, and most benefits virtually vanished after reperfusion. This is consistent with clinical findings showing a lack of benefit from hypothermia in patients presenting acute myocardial infarction in most trials...
September 28, 2016: Archives of Cardiovascular Diseases
Elodie Perdreau, Pierre-Emmanuel Séguéla, Zakaria Jalal, Adrien Perdreau, Jean-Baptiste Mouton, Marie Nelson-Veniard, Elodie Guillet, Xavier Iriart, Alexandre Ouattara, François Roubertie, Philippe Mauriat, Jean-Benoit Thambo
BACKGROUND: Left ventricular (LV) dysfunction may complicate paediatric cardiac surgery with cardiopulmonary bypass, notably after long aortic cross-clamping (ACC). Assessment of occult myocardial injury by conventional echocardiographic variables may be difficult in the postoperative period. AIMS: To evaluate the feasibility of two-dimensional (2D) strain in the postoperative period, and to assess the effect of ACC duration on this variable. METHODS: Thirty-three paediatric patients (age<18years) with congenital heart disease undergoing cardiac surgery with cardiopulmonary bypass were included in this prospective single-centre study...
September 28, 2016: Archives of Cardiovascular Diseases
Vincent Galand, Dominique Pavin, Nathalie Behar, Vincent Auffret, Damien Fénéon, Albin Behaghel, Jean-Claude Daubert, Philippe Mabo, Raphaël P Martins
BACKGROUND: Pulmonary vein (PV) isolation, using cryoballoon or radiofrequency ablation, is the cornerstone therapy for symptomatic paroxysmal atrial fibrillation (AF) refractory to antiarrhythmic drugs. One-third of the patients have recurrences, mainly due to PV reconnections. AIMS: To describe the different locations of reconnection sites in patients who had previously undergone radiofrequency or cryoballoon ablation, and to compare the characteristics of the redo procedures in both instances...
September 28, 2016: Archives of Cardiovascular Diseases
Guillaume Bonnet, Erwan Salaun, Mathieu Pankert, Thomas Cuisset, Jean-Louis Bonnet
BACKGROUND: Left atrial appendage (LAA) closure using the WATCHMAN™ device (WM) may be considered in patients with non-valvular atrial fibrillation (AF) and a high-risk of stroke who are ineligible for long-term oral anticoagulation (OAC). AIM: To report our single-centre preliminary experience, focusing on feasibility, safety and short-term efficacy of this procedure. METHODS: Patients implanted from December 2013 to February 2014 were included...
September 1, 2016: Archives of Cardiovascular Diseases
Nicolas Lamblin, Thibaud Meurice, Olivier Tricot, Gilles Lemesle, Michel Deneve, Pascal de Groote, Christophe Bauters
BACKGROUND: Limited recent data are available in the literature on whether the presence of left ventricular systolic dysfunction (LVSD) affects the therapeutic management of patients with stable coronary artery disease (CAD). AIMS: The objectives of this study were to analyse prevalence, effect on therapeutics and prognosis of LVSD in stable CAD. METHODS: We prospectively included 4184 CAD outpatients free from any myocardial infarction or coronary revascularization for>1year...
August 31, 2016: Archives of Cardiovascular Diseases
Scott J Dankel, Jeremy P Loenneke, Paul D Loprinzi
BACKGROUND: We have a limited understanding of the association between behavioural participation in muscle-strengthening activities (MSA) and all-cause mortality. AIM: To determine the effect of MSA on all-cause mortality, and examine a potential dose-response relationship between the frequency with which MSA are performed and the incidence of all-cause mortality. METHODS: Individuals (8772 adults aged≥20years) from the 2003-2006 National Health and Nutritional Examination Survey were evaluated for baseline characteristics, then followed for an average of 6...
August 31, 2016: Archives of Cardiovascular Diseases
Soraya Taleb
Atherosclerosis is an inflammatory disease within the arterial wall that is responsible for several important adverse vascular events, including coronary artery disease, myocardial infraction, stroke and peripheral artery disease. Both innate and adaptive immunity play important roles in the development of atherosclerosis. In particular, monocytes/macrophages, which are the surrogate cells of innate immunity, have important proatherogenic effects. In addition, adaptive immune responses effected by T cells play important roles in atherosclerosis...
August 29, 2016: Archives of Cardiovascular Diseases
Julien Bezin, Florence Francis, Nam Vinh Nguyen, Philip Robinson, Patrick Blin, Annie Fourrier-Réglat, Antoine Pariente, Nicholas Moore
BACKGROUND: In February 2013, a retired French professor of medicine published a book denying the benefits of statins for cardiovascular prevention. The book was the subject of extensive media coverage and multiple public discussions and debate. AIMS: To investigate the impact of this media event on use of statins among regular users. METHODS: This repeated cohort study used the French claims database sample Échantillon généraliste des bénéficiaires to identify regular statin users and quantify the number who discontinued statins after February 2013, compared to discontinuation patterns in previous years (2011 and 2012)...
July 26, 2016: Archives of Cardiovascular Diseases
Gilles Rioufol, Gérard Finet
No abstract text is available yet for this article.
October 2016: Archives of Cardiovascular Diseases
Sarah Cohen, Ariane Marelli
No abstract text is available yet for this article.
October 2016: Archives of Cardiovascular Diseases
Laurent Fauchier, Christine Alonso, Frederic Anselme, Hugues Blangy, Pierre Bordachar, Serge Boveda, Nicolas Clementy, Pascal Defaye, Jean-Claude Deharo, Patrick Friocourt, Daniel Gras, Franck Halimi, Didier Klug, Jacques Mansourati, Benjamin Obadia, Jean-Luc Pasquié, Dominique Pavin, Nicolas Sadoul, Jerome Taieb, Olivier Piot, Olivier Hanon
Despite the increasingly high rate of implantation of pacemakers (PMs) and implantable cardioverter defibrillators (ICDs) in elderly patients, data supporting their clinical and cost-effectiveness in this age stratum are ambiguous and contradictory. We reviewed the data regarding the applicability, safety and effectiveness of conventional pacing, ICDs and cardiac resynchronization therapy (CRT) in elderly patients. Although periprocedural risk may be slightly higher in the elderly, the implantation procedure for PMs and ICDs is still relatively safe in this age group...
October 2016: Archives of Cardiovascular Diseases
Diana Santos-Ribeiro, Pedro Mendes-Ferreira, Carolina Maia-Rocha, Rui Adão, Adelino F Leite-Moreira, Carmen Brás-Silva
Pulmonary arterial hypertension is a progressive syndrome based on diverse aetiologies, which is characterized by a persistent increase in pulmonary vascular resistance and overload of the right ventricle, leading to heart failure and death. Currently, none of the available treatments is able to cure pulmonary arterial hypertension; additional research is therefore needed to unravel the associated pathophysiological mechanisms. This review summarizes current knowledge related to this disorder, and the several experimental animal models that can mimic pulmonary arterial hypertension and are available for translational research...
October 2016: Archives of Cardiovascular Diseases
Jean-Marc Schleich, Frédéric Schnell, Benoît Brouant, Gerald Phan, Vincent Lafay, Laurent Bonnemains, Marc Bédossa
The number of recreational scuba divers is steadily increasing. In its latest recommendations, the French Federation of Undersea Studies and Sports listed congenital heart disease as a formal and final contraindication to scuba diving. On the other hand, with the progress made in their management, the prognosis and quality of life of patients with congenital heart diseases have improved considerably, enabling them to engage in physical and sports endeavours, which are known to confer general health and psychological benefits...
August 2016: Archives of Cardiovascular Diseases
Zakaria Jalal, Louise Galmiche, Christophe Beloin, Younes Boudjemline
BACKGROUND: Percutaneous pulmonary valve implantation (PPVI) using the bovine jugular vein Melody(®) valve (Medtronic Inc., Minneapolis, MN, USA) is safe and effective. However, post-procedural complications have been reported, the reasons for which are unclear. OBJECTIVE: To assess the impact of PPVI procedural steps on valvular histology and leaflet mechanical behaviour. METHODS: Three different valved stents (the Melody(®) valve and two homemade stents with bovine and porcine pericardium) were tested in vitro under four conditions: (1) control group; (2) crimping; (3) crimping plus inflation of low-pressure balloon; (4) condition III plus post-dilatation (high-pressure balloon)...
August 2016: Archives of Cardiovascular Diseases
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