journal
MENU ▼
Read by QxMD icon Read
search

Science Signaling

journal
https://www.readbyqxmd.com/read/28420758/the-foxm1-inhibitor-rcm-1-suppresses-goblet-cell-metaplasia-and-prevents-il-13-and-stat6-signaling-in-allergen-exposed-mice
#1
Lifeng Sun, Xiaomeng Ren, I-Ching Wang, Arun Pradhan, Yufang Zhang, Hannah M Flood, Bo Han, Jeffrey A Whitsett, Tanya V Kalin, Vladimir V Kalinichenko
Goblet cell metaplasia and excessive mucus secretion associated with asthma, cystic fibrosis, and chronic obstructive pulmonary disease contribute to morbidity and mortality worldwide. We performed a high-throughput screen to identify small molecules targeting a transcriptional network critical for the differentiation of goblet cells in response to allergens. We identified RCM-1, a nontoxic small molecule that inhibited goblet cell metaplasia and excessive mucus production in mice after exposure to allergens...
April 18, 2017: Science Signaling
https://www.readbyqxmd.com/read/28420757/stress-signals-in-plants
#2
Alexandra A Mushegian
Selective autophagy mediates the cross-talk between plant growth and stress signaling pathways.
April 18, 2017: Science Signaling
https://www.readbyqxmd.com/read/28420756/microbes-stimulate-hair-follicles
#3
Annalisa M VanHook
Commensal microbes induce hair follicles to release a chemokine that recruits regulatory T cells into neonatal skin.
April 18, 2017: Science Signaling
https://www.readbyqxmd.com/read/28420755/papers-of-note-in-science-translational-medicine9-385
#4
Leslie K Ferrarelli
This week's articles show that combining antiangiogenic therapy and immune checkpoint inhibition improves antitumor immunity.
April 18, 2017: Science Signaling
https://www.readbyqxmd.com/read/28420754/paper-of-note-in-science356-6334
#5
Annalisa M VanHook
This week's article highlights the contribution of T cell reactivity to nonviral antigens to the success of adoptive T cell transfer in treating a virus-driven cancer.
April 18, 2017: Science Signaling
https://www.readbyqxmd.com/read/28420753/the-kinase-tpl2-activates-erk-and-p38-signaling-to-promote-neutrophilic-inflammation
#6
Kate Senger, Victoria C Pham, Eugene Varfolomeev, Jason A Hackney, Cesar A Corzo, Jenna Collier, Vivian W C Lau, Zhiyu Huang, Kajal Hamidzhadeh, Patrick Caplazi, Ivan Peng, A Francesca Setiadi, Ross Francis, Andres Paler-Martinez, Youngsu C Kwon, Vladimir Ramirez-Carrozzi, Yonglian Sun, Patricia W Grigg, Merone Roose-Girma, Surinder Jeet, Kai H Barck, Anna Pham, Naruhisa Ota, Connie Ha, Jeremy Stinson, Joseph Guillory, Lucinda Tam, Zora Modrusan, Claire Emson, Brent S McKenzie, Michael J Townsend, Richard A D Carano, Søren Warming, Domagoj Vucic, Jason DeVoss, Wyne P Lee, Jennie R Lill, Ali A Zarrin
Tumor progression locus 2 (TPL2; also known as MAP3K8) is a mitogen-activated protein kinase (MAPK) kinase kinase (MAP3K) that phosphorylates the MAPK kinases MEK1 and MEK2 (MEK1/2), which, in turn, activate the MAPKs extracellular signal-regulated kinase 1 (ERK1) and ERK2 (ERK1/2) in macrophages stimulated through the interleukin-1 receptor (IL-1R), Toll-like receptors (TLRs), or the tumor necrosis factor receptor (TNFR). We describe a conserved and critical role for TPL2 in mediating the effector functions of neutrophils through the activation of the p38 MAPK signaling pathway...
April 18, 2017: Science Signaling
https://www.readbyqxmd.com/read/28420752/highlight-a-new-way-to-block-the-development-of-asthma-from-dust-mites
#7
Michael Yaffe
Targeting a transcription factor, generally considered to be "nondruggable," may help to prevent asthma from developing.
April 18, 2017: Science Signaling
https://www.readbyqxmd.com/read/28420751/control-of-potassium-homeostasis-is-an-essential-function-of-the-second-messenger-cyclic-di-amp-in-bacillus-subtilis
#8
Jan Gundlach, Christina Herzberg, Volkhard Kaever, Katrin Gunka, Tamara Hoffmann, Martin Weiß, Johannes Gibhardt, Andrea Thürmer, Dietrich Hertel, Rolf Daniel, Erhard Bremer, Fabian M Commichau, Jörg Stülke
The second messenger cyclic di-adenosine monophosphate (c-di-AMP) is essential in the Gram-positive model organism Bacillus subtilis and in related pathogenic bacteria. It controls the activity of the conserved ydaO riboswitch and of several proteins involved in potassium (K(+)) uptake. We found that the YdaO protein was conserved among several different bacteria and provide evidence that YdaO functions as a K(+) transporter. Thus, we renamed the gene and protein KimA (K(+) importer A). Reporter activity assays indicated that expression beyond the c-di-AMP-responsive riboswitch of the kimA upstream regulatory region occurred only in bacteria grown in medium containing low K(+) concentrations...
April 18, 2017: Science Signaling
https://www.readbyqxmd.com/read/28400538/the-transcription-factor-mafk-induces-emt-and-malignant-progression-of-triple-negative-breast-cancer-cells-through-its-target-gpnmb
#9
Yukari Okita, Minori Kimura, Rudy Xie, Chen Chen, Larina Tzu-Wei Shen, Yurika Kojima, Hiroyuki Suzuki, Masafumi Muratani, Masao Saitoh, Kentaro Semba, Carl-Henrik Heldin, Mitsuyasu Kato
Triple-negative breast cancer (TNBC) is particularly aggressive and difficult to treat. For example, the transforming growth factor-β (TGF-β) pathway is implicated in TNBC progression and metastasis, but its opposing role in tumor suppression in healthy tissues and early-stage lesions makes it a challenging target. Therefore, additional molecular characterization of TNBC may lead to improved patient prognosis by informing the development and optimum use of targeted therapies. We found that musculoaponeurotic fibrosarcoma (MAF) oncogene family protein K (MAFK), a member of the small MAF family of transcription factors that are induced by the TGF-β pathway, was abundant in human TNBC and aggressive mouse mammary tumor cell lines...
April 11, 2017: Science Signaling
https://www.readbyqxmd.com/read/28400537/yap-mediated-mechanotransduction-determines-the-podocyte-s-response-to-damage
#10
Markus M Rinschen, Florian Grahammer, Ann-Kathrin Hoppe, Priyanka Kohli, Henning Hagmann, Oliver Kretz, Sabine Bertsch, Martin Höhne, Heike Göbel, Malte P Bartram, Rajesh Kumar Gandhirajan, Marcus Krüger, Paul-Thomas Brinkkoetter, Tobias B Huber, Martin Kann, Sara A Wickström, Thomas Benzing, Bernhard Schermer
Podocytes are terminally differentiated cells of the kidney filtration barrier. They are subjected to physiological filtration pressure and considerable mechanical strain, which can be further increased in various kidney diseases. When injury causes cytoskeletal reorganization and morphological alterations of these cells, the filtration barrier may become compromised and allow proteins to leak into the urine (a condition called proteinuria). Using time-resolved proteomics, we showed that podocyte injury stimulated the activity of the transcriptional coactivator YAP and the expression of YAP target genes in a rat model of glomerular disease before the development of proteinuria...
April 11, 2017: Science Signaling
https://www.readbyqxmd.com/read/28400536/nls-protects-dna-damage-protein
#11
Alexandra A Mushegian
A single motif targets a protein to the nucleus and directs its deubiquitylation, promoting high-fidelity DNA damage repair.
April 11, 2017: Science Signaling
https://www.readbyqxmd.com/read/28400535/hippo-sized-antiviral-defenses
#12
Wei Wong
The Hippo signaling pathway modulates the strength of antiviral responses according to nutritional status or cell density.
April 11, 2017: Science Signaling
https://www.readbyqxmd.com/read/28400534/papers-of-note-in-science-translational-medicine9-384
#13
Leslie K Ferrarelli
This week's articles reveal how drugs that prime the tumor stroma can enhance chemotherapy and how disrupting select chemokine interactions might treat inflammatory disease.
April 11, 2017: Science Signaling
https://www.readbyqxmd.com/read/28400533/papers-of-note-in-nature544-7648
#14
Annalisa M VanHook
This week's highlighted article shows that adiponectin receptors may transduce signaling by acting as ceramidases.
April 11, 2017: Science Signaling
https://www.readbyqxmd.com/read/28400532/papers-of-note-in-science356-6333
#15
Annalisa M VanHook
This week's articles identify a potential cause for the development of celiac disease and a method for targeting an AMPA receptor agonist to specific neurons.
April 11, 2017: Science Signaling
https://www.readbyqxmd.com/read/28400531/genomics-and-evolution-of-protein-phosphatases
#16
Mark J Chen, Jack E Dixon, Gerard Manning
Protein phosphatases are the essential opposite to protein kinases; together, these enzymes regulate all protein phosphorylation and most cellular processes. To better understand the global roles of protein phosphorylation, we cataloged the human protein phosphatome, composed of 189 known and predicted human protein phosphatase genes. We also identified 79 protein phosphatase pseudogenes or retrogenes, some of which may have residual function. We traced the origin and diversity of phosphatases by building protein phosphatomes for eight other eukaryotes, from the protist Dictyostelium to the sea urchin...
April 11, 2017: Science Signaling
https://www.readbyqxmd.com/read/28377412/astrocyte-shed-extracellular-vesicles-regulate-the-peripheral-leukocyte-response-to-inflammatory-brain-lesions
#17
Alex M Dickens, Luis B Tovar-Y-Romo, Seung-Wan Yoo, Amanda L Trout, Mihyun Bae, Marlene Kanmogne, Bezawit Megra, Dionna W Williams, Kennith W Witwer, Mar Gacias, Nino Tabatadze, Robert N Cole, Patrizia Casaccia, Joan W Berman, Daniel C Anthony, Norman J Haughey
Brain injury induces a peripheral acute cytokine response that directs the transmigration of leukocytes into the brain. Because this brain-to-peripheral immune communication affects patient recovery, understanding its regulation is important. Using a mouse model of inflammatory brain injury, we set out to find a soluble mediator for this phenomenon. We found that extracellular vesicles (EVs) shed from astrocytes in response to intracerebral injection of interleukin-1β (IL-1β) rapidly entered into peripheral circulation and promoted the transmigration of leukocytes through modulation of the peripheral acute cytokine response...
April 4, 2017: Science Signaling
https://www.readbyqxmd.com/read/28377411/the-lysine-deacetylase-sirtuin-1-modulates-the-localization-and-function-of-the-notch1-receptor-in-regulatory-t-cells
#18
Nimi Marcel, Lakshmi R Perumalsamy, Sanjay K Shukla, Apurva Sarin
The ability to tune cellular functions in response to nutrient availability has important consequences for immune homeostasis. The activity of the receptor Notch in regulatory T (Treg) cells, which suppress the functions of effector T cells, is indispensable for Treg cell survival under conditions of diminished nutrient supply. Anti-apoptotic signaling induced by the Notch1 intracellular domain (NIC) originates from the cytoplasm and is spatially decoupled from the nuclear, largely transcriptional functions of NIC...
April 4, 2017: Science Signaling
https://www.readbyqxmd.com/read/28377410/papers-of-note-in-science-immunology2-9
#19
John F Foley
This month's articles show how an anti-inflammatory mediator is required for allergic responses, how targeting of the deacetylase Sirtuin 1 may provide a therapy against Mycobacterium tuberculosis infection, and how an inhibitory receptor limits the proliferation of regulatory T cells in autoimmune diabetes.
April 4, 2017: Science Signaling
https://www.readbyqxmd.com/read/28377409/impaired-phagocytosis-in-fragile-x
#20
Alexandra A Mushegian
Defects in phagocytosis underlie both neurological and immunological symptoms in a fly model of fragile X syndrome.
April 4, 2017: Science Signaling
journal
journal
41873
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"