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BMB Reports

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https://www.readbyqxmd.com/read/30355438/protective-effects-of-n-4-5-trimethylthiazol-2-amine-hydrochloride-on-hypoxia-induced-%C3%AE-amyloid-production-in-sh-sy5y-cells
#1
A Reum Han, Ji Woong Yang, Jung-Min Na, Soo Young Choi, Sung-Woo Cho
Although hypoxic/ischemic injury is thought to contribute to the incidence of Alzheimer's disease (AD), the molecular mechanism that determines the relationship between hypoxia-induced β-amyloid (Aβ) generation and development of AD is not yet known. We have now investigated the protective effects of N,4,5-trimethylthiazol-2-amine hydrochloride (KHG26702), a novel thiazole derivative, on oxygen-glucose deprivation (OGD)-reoxygenation (OGD-R)-induced Aβ production in SH-SY5Y human neuroblastoma cells. Pretreatment of these cells with KHG26702 significantly attenuated OGD-R-induced production of reactive oxygen species and elevation of levels of malondialdehyde, prostaglandin E2, interleukin 6 and glutathione, as well as superoxide dismutase activity...
October 24, 2018: BMB Reports
https://www.readbyqxmd.com/read/30355437/generation-and-characterization-of-a-monoclonal-antibody-against-mers-cov-targeting-the-spike-protein-using-a-synthetic-peptide-epitope-cpg-dna-liposome-complex
#2
Byoung Kwon Park, Sony Maharjan, Su In Lee, Jinsoo Kim, Joon-Yong Bae, Man-Seong Park, Hyung-Joo Kwon
Middle East respiratory syndrome coronavirus (MERS-CoV) uses the spike (S) glycoprotein to recognize and enter target cells. In this study, we selected two epitope peptide sequences within the receptor binding domain (RBD) of the MERS-CoV S protein. We used a complex consisting of the epitope peptide of the MERS-CoV S protein and CpG-DNA encapsulated in liposome complex to immunize mice, and produced the monoclonal antibodies 506-2G10G5 and 492-1G10E4E2. The western blotting data showed that both monoclonal antibodies detected the S protein and immunoprecipitated the native form of the S protein...
October 24, 2018: BMB Reports
https://www.readbyqxmd.com/read/30355436/ccaat-enhancer-binding-protein-beta-c-ebp%C3%AE-is-an-important-mediator-of-1-25-dihydroxyvitamin-d3-1-25d3-induced-receptor-activator-of-nuclear-factor-kappa-b-ligand-rankl-expression-in-osteoblasts
#3
Sungsin Jo, Yun Young Lee, Jinil Han, Young Lim Lee, Subin Yoon, Jaehyun Lee, Younseo Oh, Joong-Soo Han, Il-Hoon Sung, Ye-Soo Park, Tae-Hwan Kim
Receptor activator of nuclear factor kappa B ligand (RANKL) expression in osteoblasts is regulated by 1,25-dihydroxyvitamin D3 (1,25D3). CCAAT/enhancer-binding protein beta (C/EBPβ) has been proposed to function as a transcription factor and upregulate RANKL expression, but it is still uncertain how C/EBPβ is involved in 1,25D3-induced RANKL expression of osteoblasts. 1,25D3 stimulation increased the expression of RANKL and C/EPBβ genes in osteoblasts and enhanced phosphorylation and stability of these proteins...
October 24, 2018: BMB Reports
https://www.readbyqxmd.com/read/30293551/cellular-machinery-for-sensing-mechanical-force
#4
Chul-Gyun Lim, Jiyoung Jang, Chungho Kim
For mechanical force to induce changes in cellular behaviors, two main processes are inevitable; perception of the force and response to it. Perception of mechanical force by cells, or mechanosensing, requires mechanical force-induced conformational changes in mechanosensors. For this, at least one end of the mechanosensors should be anchored to relatively fixed structures, such as extracellular matrices or the cytoskeletons, while the other end should be pulled along the direction of the mechanical force. Alternatively, mechanosensors may be positioned in lipid bilayers, so that conformational changes in the embedded sensors can be induced by mechanical force-driven tension in the lipid bilayer...
October 8, 2018: BMB Reports
https://www.readbyqxmd.com/read/30293550/functions-of-dead-box-rna-helicases-ddx5-and-ddx17-in-chromatin-organization-and-transcriptional-regulation
#5
Guillaume Giraud, Sophie Terrone, Cyril F Bourgeois
RNA helicases DDX5 and DDX17 are multitasking proteins that regulate gene expression in different biological contexts through diverse activities. Special attention has long been paid to their function as coregulators of transcription factors, providing insight about their functional association with a number of chromatin modifiers and remodelers. However, to date, the variety of described mechanisms has made it difficult to understand precisely how these proteins work at the molecular level, and the contribution of their ATPase domain to these mechanisms remains unclear as well...
October 8, 2018: BMB Reports
https://www.readbyqxmd.com/read/30293549/enhanced-delivery-of-protein-fused-to-cell-penetrating-peptides-to-mammalian-cells
#6
Jung-Il Moon, Min-Joon Han, Shin-Hye Yu, Eun-Hye Lee, Sang-Mi Kim, Kyuboem Han, Chang-Hwan Park, Chun-Hyung Kim
Recent progress in cellular reprogramming technology and lineage-specific cell differentiation has provided great opportunities for translational research. Because virus-based gene delivery is not a practical reprogramming protocol, protein-based reprogramming has been receiving attention as a safe way to generate reprogrammed cells. However, the poor efficiency of the cellular uptake of reprogramming proteins is still a major obstacle. Here, we reported key factors which improve the cellular uptake of these proteins...
October 8, 2018: BMB Reports
https://www.readbyqxmd.com/read/30293548/leptin-stimulates-igf-1-transcription-by-activating-ap-1-in-human-breast-cancer-cells
#7
Dong Yeong Min, Euitaek Jung, Juhwan Kim, Young Han Lee, Soon Young Shin
Leptin, an adipokine regulating energy metabolism, appears to be associated with breast cancer progression. Insulin-like growth factor-1 (IGF-1) mediates the pathogenesis of breast cancer. The regulation of IGF-1 expression by leptin in breast cancer cells is unclear. Here, we found that leptin upregulates IGF-1 expression at the transcriptional level in breast cancer cells. Activating protein-1 (AP-1)-binding element within the proximal region of IGF-1 was necessary for leptin-induced IGF-1 promoter activation...
October 8, 2018: BMB Reports
https://www.readbyqxmd.com/read/30293547/overexpression-of-cxcl2-inhibits-cell-proliferation-and-promotes-apoptosis-in-hepatocellular-carcinoma
#8
Jun Ding, Kangdi Xu, Jie Zhang, Bingyi Lin, Yubo Wang, Shengyong Yin, Haiyang Xie, Lin Zhou, Shusen Zheng
C-X-C motif chemokine ligand 2 (CXCL2) is a small secreted protein that exhibits a structure similar to the proangiogenic subgroup of the CXC chemokine family. Recently, accumulating evidence suggests that chemokines play a pivotal role in cancer progression and carcinogenesis. We examined the expression levels of 7 types of ELR+ CXCLs messenger RNA (mRNA) in 264 clinical samples. We found that CXCL2 expression was stably down-regulated in 94% of hepatocellular carcinoma (HCC) specimens compared with paired adjacent normal liver tissues and some HCC cell lines...
October 8, 2018: BMB Reports
https://www.readbyqxmd.com/read/30293546/interferon-%C3%AE-mediated-secretion-of-tryptophanyl-trna-synthetases-has-a-role-in-protection-of-human-umbilical-cord-blood-derived-mesenchymal-stem-cells-against-experimental-colitis
#9
Insung Kang, Byung-Chul Lee, Jin Young Lee, Jae-Jun Kim, Seung-Eun Lee, Nari Shin, Soon Won Choi, Kyung-Sun Kang
Mesenchymal stem cells (MSCs) are multipotent adult stem cells that present immunosuppressive effects in experimental and clinical trials targeting various rare diseases including inflammatory bowel disease (IBD). In addition, recent studies have reported tryptophanyl-tRNA synthetase (WRS) possess uncanonical roles such as angiostatic and anti-inflammatory effects. However, little is known about the function of WRS in MSC-based therapy. In this study, we investigated if a novel factor, WRS, secreted from MSCs has a role in amelioration of IBD symptoms and determined a specific mechanism underlying MSC therapy...
October 8, 2018: BMB Reports
https://www.readbyqxmd.com/read/30293545/human-umbilical-cord-blood-plasma-alleviates-age-related-olfactory-dysfunction-by-attenuating-peripheral-tnf-%C3%AE-expression
#10
Byung-Chul Lee, Insung Kang, Seung-Eun Lee, Jin Young Lee, Nari Shin, Jae-Jun Kim, Soon Won Choi, Kyung-Sun Kang
Social requirements are needed for living in an aging society and individual longevity. Among them, improved health and medical cares, appropriate for an aging society are strongly demanded. Human cord blood-derived plasma (hUCP) has recently emerged for its unique anti-aging effects. In this study, we investigated brain rejuvenation, particularly olfactory function, that could be achieved by a systemic administration of young blood and its underlying mechanisms. Older than 24-month-old mice were used as an aged group and administered with intravenous injection of hUCP repetitively, eight times...
October 8, 2018: BMB Reports
https://www.readbyqxmd.com/read/30269744/roles-of-mitochondria-in-neuronal-development
#11
Geurim Son, Jinju Han
Mitochondria are ubiquitous and multi-functional organelles involved in diverse metabolic processes, namely energy production and biomolecule synthesis. The intracellular mitochondrial morphology and distribution change dynamically, which reflect the metabolic state of a given cell type. A dramatic change of the mitochondrial dynamics has been observed in early development that led to further investigations on the relationship between mitochondria and the process of development. A significant developmental process to focus on, in this review, is a differentiation of neural progenitor cells into neurons...
October 1, 2018: BMB Reports
https://www.readbyqxmd.com/read/30269740/stk899704-inhibits-stemness-of-cancer-stem-cells-and-migration-via-the-fak-mek-erk-pathway-in-ht29-cells
#12
Hui-Ju Jang, Yesol Bak, Thu-Huyen Pham, Sae-Bom Kwon, Bo-Yeon Kim, JinTae Hong, Do-Young Yoon
Colon cancer is one of the most lethal and common malignancies worldwide. STK899704, a novel synthetic agent, has been reported to exhibit anticancer effects towards numerous cancer cells. However, the effect of STK899704 on the biological properties of colon cancer, including cancer cell migration and cancer stem cells (CSCs), remains unknown. Here, we examined the inhibitory effect of STK899704 on cell migration and CSC stemness. In the wound healing assay, STK899704 significantly inhibited the motility of colon cancer cells...
October 1, 2018: BMB Reports
https://www.readbyqxmd.com/read/30269739/microrna-301b-promotes-cell-proliferation-and-apoptosis-resistance-in-triple-negative-breast-cancer-by-targeting-cyld
#13
Hongming Song, Dengfeng Li, Tianqi Wu, Dan Xie, Kaiyao Hua, Jiashu Hu, Xiaochong Deng, Changle Ji, Yijun Deng, Lin Fang
Aberrant expression of microRNAs (miRNAs) plays important roles in carcinogenesis and tumor progression. However, the expression and biological role of miR-301b in triple-negative breast cancer (TNBC) remains unclear. Here we aimed to evaluate the roles and mechanisms of miR-301b in TNBC cells. miR-301b expression was assessed in TNBC specimens and cell lines by quantitative Real-Time PCR (qRT-PCR). TNBC cells were transfected with miR-301b mimic or inhibitor or Cylindromatosis (CYLD) small interfering RNA (siRNA) using Lipofectamine 2000...
October 1, 2018: BMB Reports
https://www.readbyqxmd.com/read/30158024/renal-protective-effects-of-zingerone-in-a-mouse-model-of-sepsis
#14
Bong-Seon Lee, Changhun Lee, Sumin Yang, Sae-Kwang Ku, Jong-Sup Bae
Zingerone (ZGR), a phenolic alkanone isolated from ginger, has been reported to possess pharmacological activities such as anti-inflammatory and anti-apoptotic effects. This study was initiated to determine whether ZGR could modulate renal functional damage in a mouse model of sepsis and to elucidate the underlying mechanisms. The potential of ZGR treatment to reduce renal damage induced by cecal ligation and puncture (CLP) surgery in mice was measured by assessment of serum creatinine, blood urea nitrogen (BUN), lipid peroxidation, total glutathione, glutathione peroxidase activity, catalase activity, and superoxide dismutase activity...
August 30, 2018: BMB Reports
https://www.readbyqxmd.com/read/30158023/downregulated-micrornas-in-the-colorectal-cancer-diagnostic-and-therapeutic-perspectives
#15
Rosa Hernández, Ester Sánchez-Jiménez, Consolación Melguizo, Jose Prados, Ana Rosa Rama
Colorectal cancer (CRC), the third most common cancer in the world, has no specific biomarkers that facilitate its diagnosis and subsequent treatment. The miRNAs, small single-stranded RNAs that repress the mRNA translation and trigger the mRNA degradation, show aberrant levels in the CRC, by which these molecules have been related with the initiation, progression, and drug-resistance of this cancer type. Numerous studies show the microRNAs influence the cellular mechanisms related to the cell cycle, differentiation, apoptosis, and migration of the cancer cells through the post-transcriptionally regulated gene expression...
August 30, 2018: BMB Reports
https://www.readbyqxmd.com/read/30269745/the-origin-of-cell-harboring-cancer-driving-mutations-in-human-glioblastoma
#16
Joo Ho Lee, Jeong Ho Lee
Glioblastoma (GBM) is the most common and aggressive form of human adult brain malignancy. The identification of the cell of origin harboring cancer-driver mutations is the fundamental issue for understanding the nature of GBM and developing the effective therapeutic target. It has been a long-term hypothesis that neural stem cells in the subventricular zone (SVZ) might be the origin-of-cells in human glioblastoma since they are known to have life-long proliferative activity and acquire somatic mutations. However, the cell of origin for GBM remains controversial due to lack of direct evidence thereof in human GBM...
October 2018: BMB Reports
https://www.readbyqxmd.com/read/30269743/regulation-of-rip3-protein-stability-by-peli1-mediated-proteasome-dependent-degradation
#17
Han-Hee Park, Michael J Morgan, Ho Chul Kang, You-Sun Kim
Receptor-interacting protein kinase-3 (RIP3 or RIPK3) is a serine-threonine kinase largely essential for necroptotic cell death; it also plays a role in some inflammatory diseases. High levels of RIP3 are likely sufficient to activate necroptotic and inflammatory pathways downstream of RIP3 in the absence of an upstream stimulus. For example, we have previously detected high levels or RIP3 in the skin of Toxic Epidermal Necrolysis patients; this correlates with increased phosphorylation of MLKL found in these patients...
October 2018: BMB Reports
https://www.readbyqxmd.com/read/30269742/microrna-controls-of-cellular-senescence
#18
Nayoung Suh
Cellular senescence is a state of permanent cell-cycle arrest triggered by different internal and external stimuli. This phenomenon is considered to be both beneficial and detrimental depending on the cell types and biological contexts. During normal embryonic development and after tissue injury, cellular senescence is critical for tissue remodeling. In addition, this process is useful for arresting growth of tumor cells, particularly during early onset of tumorigenesis. However, accumulation of senescent cells decreases tissue regenerative capabilities and induces inflammation, which is responsible for cancer and organismal aging...
October 2018: BMB Reports
https://www.readbyqxmd.com/read/30269741/pep-1-paraoxonase-1-fusion-protein-prevents-cytokine-induced-cell-destruction-and-impaired-insulin-secretion-in-rat-insulinoma-cells
#19
Su Jin Lee, Hyung Kyung Kang, Yeon Joo Choi, Won Sik Eum, Jinseu Park, Soo Young Choi, Hyeok Yil Kwon
Pancreatic beta cell destruction and dysfunction induced by cytokines is a major cause of type 1 diabetes. Paraoxonase 1 (PON1), an arylesterase with antioxidant activity, has been shown to play an important role in preventing the development of diabetes in transgenic mice. However, no studies have examined the anti-diabetic effect of PON1 delivered to beta cells using protein transduction. In this study, we expressed the cell-permeable PON1 fused with PEP-1 protein transduction domain (PEP-1-PON1) to investigate whether transduced PEP-1-PON1 protects beta cells against cytokine-induced cytotoxicity...
October 2018: BMB Reports
https://www.readbyqxmd.com/read/30269738/cordycepin-inhibits-lipopolysaccharide-induced-cell-migration-and-invasion-in-human-colorectal-carcinoma-hct-116-cells-through-down-regulation-of-prostaglandin-e2-receptor-ep4
#20
Jin-Woo Jeong, Cheol Park, Hee-Jae Cha, Su Hyun Hong, Shin-Hyung Park, Gi-Young Kim, Woo Jean Kim, Cheol Hong Kim, Kyoung Seob Song, Yung Hyun Choi
Prostaglandin E2 (PGE2), a major product of cyclooxygenase-2 (COX-2), plays an important role in the carcinogenesis of many solid tumors, including colorectal cancer. Because PGE2 functions by signaling through PGE2 receptors (EPs), which regulate tumor cell growth, invasion, and migration, there has been a growing amount of interest in the therapeutic potential of targeting EPs. In the present study, we investigated the role of EP4 on the effectiveness of cordycepin in inhibiting the migration and invasion of HCT116 human colorectal carcinoma cells...
October 2018: BMB Reports
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