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Systems Biology in Reproductive Medicine

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https://www.readbyqxmd.com/read/29099633/aging-deteriorates-quality-of-sperm-produced-by-male-mice-with-partial-yq-deletion
#1
Katarzyna Kotarska, Andrzej Doniec, Magdalena Bednarska, Zbigniew Polański, Józefa Styrna
The aim of the study was to assess the cumulative effects of aging and Y-chromosome long arm deletion on sperm quality parameters. Motility, mitochondrial activity, and head morphology were evaluated for sperm of 3- and 12-month-old males from B10.BR-Y(del) and B10.BR congenic mouse strains. The study revealed that quality and fertilizing potential of sperm produced by younger and older B10.BR males persist on similar levels, but worsen significantly with age of B10.BR-Y(del) males. The findings imply that partial Yq deletions might be more harmful for spermiogenesis in advancing age and may be applicable to other species including humans...
November 3, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29099629/regulatory-t-cells-improve-pregnancy-rate-in-rif-patients-after-additional-ivig-treatment
#2
Majid Ahmadi, Samaneh Abdolmohammadi-Vahid, Mahnaz Ghaebi, Leili Aghebati-Maleki, Sanam Dolati, Laya Farzadi, Aliyeh Ghasemzadeh, Kobra Hamdi, Vahid Younesi, Mohammad Nouri, Mehdi Yousefi
RIF (repeated implantation failure) women with immunologic basis and cellular abnormalities may benefit from intravenous immunoglobulins (IVIG) as an immunomodulator based on different studies. In this study, we evaluated the effect of IVIG on the frequency and function of Th17 and Treg cells, as two important subgroups of CD4(+) T cells in implantation and pregnancy rates. Seventy-two RIF patients with preconception Th1⁄Th2 ratio and natural killer (NK) cells frequency and activity elevation were selected and divided into two groups; 40 out of 72 received IVIG, aspirin, and heparin (anoxaparin) and constituted the treatment group and 32 patients received aspirin and heparin (anoxaparin) and no IVIG and were the control group...
November 3, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29087729/insulin-resistance-in-patients-with-recurrent-pregnancy-loss-is-associated-with-lymphocyte-population-aberration
#3
Yan Yan, Shihua Bao, Shile Sheng, Liuliu Wang, Weiyan Tu
This study was designed to investigate the relationship of insulin resistance (IR) and cellular immune abnormalities associated with women with recurrent pregnancy loss (RPL). Women with RPL were divided into two groups according to their homeostasis model assessment for IR (HOMA-IR) scores. The IR group received metformin approximately 3 months before pregnancy. The percentage of lymphocyte subsets and other blood biochemical indices were tested. The HOMA-IR and fasting serum insulin levels were related to the percentage of lymphocyte subsets...
October 31, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29083935/tri-nucleotide-consortium-of-androgen-receptor-is-associated-with-low-serum-fsh-and-testosterone-in-asthenospermic-men
#4
Haroon Latif Khan, Shahzad Bhatti, Sana Abbas, Yousaf Latif Khan, Muhammad Aslamkhan, Rosa Maria Marquez Gonzalez, Gerardo Rodriguez Gonzalez, Hikmet Hakan Aydin, Magali Segundo Trinidad
Androgen mediating signaling is implicated in regulating the expression of reproductive related genes. Any deviation in the gene expression might be the ignitable precursor for genomic instability that inflames the genomic rearrangements and a leading cause of cancer. The main goal of this study was to determine the relationships between trinucleotide repeats of androgen receptor (AR), sex steroids, and sexual function in men presenting with reduced sperm motility. We investigated the singleton or combinatorial effects of the length of trinucleotide repeats of AR on reproductive hormones, clinical parameters, semen analyses, as well as sexual assessment function of 210 asthenospermic outpatients along with 125 normal subjects...
October 30, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29020465/donor-sperm-insemination-after-failed-intra-couple-intracytoplasmic-sperm-injection
#5
Sylviane Hennebicq, Oxana Blagosklonov, Florence Eustache, Aline Papaxanthos, Veronique Drouineaud, Catherine Guillemain, Sophie Mirallie, Beatrice Delepine, Nathalie Rives, Isabelle Berthaut, Cynthia Frapsauce, Jean-François Guérin, Mehdi Benchaib
The purpose of the present multicenter study was to investigate whether an artificial insemination with donor sperm (AID) procedure after intra-couple intracytoplasmic sperm injection (ICSI) failure offers a significant chance of pregnancy and to identify prognostic factors for pregnancy after an AID procedure. An eleven-year retrospective multicenter study was conducted among 13 Centre d'Etude et de Conservation des Oeufs et du Sperme (CECOS) centers. A total of 319 couples having undergone an AID procedure after intra-conjugal ICSI failure were included in this study; a total of 1,159 AID and 1,011 intra-conjugal ICSI cycles were performed...
October 11, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28991497/polymorphisms-of-dna-repair-genes-xrcc1-and-lig4-and-idiopathic-male-infertility
#6
Hadi Ghasemi, Iraj Khodadadi, Amir Fattahi, Abbas Moghimbeigi, Heidar Tavilani
Sperm DNA damage is one of the associated factors of idiopathic male infertility and abnormal spermatogenesis. This study was conducted to assess possible association between risk of male infertility with X-ray repair cross complementing group 1 (XRCC1) Arg399Gln (G to A) and DNA ligase 4 (LIG4) Thr9Ile (C to T) gene polymorphisms which are involved in different DNA repair pathways. In this case-control study 191 fertile and 191 infertile men (29-40 years old) were enrolled. The single-nucleotide polymorphism genotypes and alleles of XRCC1 Arg399Gln and LIG4 Thr9Ile were assessed using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique...
October 9, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28886262/effectiveness-of-antibiotic-treatment-in-infertile-patients-with-sterile-leukocytospermia-induced-by-tobacco-use
#7
Bogdan Pajovic, Ljiljana Pajovic, Marko Vukovic
Our study investigated whether antibiotic therapy in infertile tobacco users with sterile leukocytospermia and a history of former sexual transmitted disease (STD) has an advantage over cessation of smoking alone. For this study, 80 male infertile smokers were divided into two subgroups. The first group numbered 40 patients treated with a two week course of doxycycline, 100 mg, twice daily, while the second group simply ceased smoking. A control group of 20 patients with chronic abacterial prostatitis (CPPS III a) were treated with the same antibiotic for two weeks...
September 8, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28846448/in-vitro-effects-of-melatonin-on-colonization-of-neonate-mouse-spermatogonial-stem-cells
#8
Shadan Navid, Tayebeh Rastegar, Maryam Baazm, Rafieh Alizadeh, Ali Talebi, Keykavos Gholami, Somayeh Khosravi-Farsani, Morteza Koruji, Mehdi Abbasi
We have recently reported that antioxidant supplements enhance the efficacy of cryopreserved spermatogonial stem cells. Melatonin is considered a free radical scavenger which has direct and indirect antioxidant effects in in vitro and in vivo microenvironments. Due to the anti-apoptotic properties of melatonin, researchers have proposed that melatonin may improve the efficiency of spermatogonial stem cell (SSC) transplantation. However, the appropriate methodology which facilitates SSC proliferation remains to be determined...
August 28, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28841339/the-influence-of-semen-quality-on-male-pronucleus-demethylation-process-during-icsi-cycle
#9
Hoda Rajabi, Homa Mohseni-Kouchesfehani, Mohammad Salehi, Fattaneh Farifteh-Nobijari, Tarlan Eslami-Arshaghi
There is growing evidence that the spermatozoon's epigenetic structure is of the utmost importance in the health of the future embryo. Following fertilization, sperm chromatin undergoes epigenetic reprogramming including DNA demethylation and remethylation, which resets gene expression. In some infertile patients, it is inevitable that sperm cells that are not within the range of normal human sperm parameters will be used for intracytoplasmic sperm injection. Understanding the relationship between the human sperm parameters and male pronucleus DNA demethylation seems necessary...
August 25, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28795845/analysis-of-embryo-intactness-and-developmental-potential-following-slow-freezing-and-vitrification
#10
Lan Yu, Chanwei Jia, Yonglian Lan, Rui Song, Liying Zhou, Ying Li, Yu Liang, Shuyu Wang
The aim of this study was to identify the parameters that are related to intactness and developmental potential of a day 3 embryo after warming to improve the selection criteria used to cryopreserve and transfer embryos. We also sought to compare slow freezing and vitrification methods of cryopreservation and to evaluate the viability of non-intact embryos. Embryos warmed following slow freezing (n=220) or vitrification (n=522) were divided into 3 groups according to the proportion of surviving blastomeres (I<50%; II=50-99%; and III=100%)...
October 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28787189/sperm-na-k-atpase-%C3%AE-4-and-plasma-membrane-ca-2-atpase-pmca-4-regulation-in-asthenozoospermia
#11
Silvia W Lestari, Dessy Noor Miati, P Seoharso, R Sugiyanto, Dwi A Pujianto
Asthenozoospermia, which is characterized by reduced motility, is one of the etiologies of male infertility. Its biochemical and functional consequences include altered ATPase activity. This study investigated the activities of Na(+), K(+)-ATPase and Ca(2+)-ATPase and the expression of Na(+), K(+)-ATPase α4 and PMCA4 isoforms in human sperm of asthenozoospermic infertile men. Nineteen samples from asthenozoospermic infertile couples were examined in this study. Computerized-assisted semen analysis (CASA) was performed, and the enzyme activity was measured based on the ability of ATPase to release organic phosphate from ATP as a substrate...
October 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28771041/obstructive-azoospermia-caused-by-low-ligation-of-varicocele-a-case-report
#12
Jun Hagiuda, Hiromichi Ishikawa, Masayuki Hagiwara, Hidaka Kono, Ken Nakagawa, Mototsugu Oya
Varicocele is commonly observed in male partners of infertile couples. The surgical ligation of varicoceles under microscopy can be safely performed by a skilled andrologist with most patients subsequently experiencing an improvement in semen quality. This is the first case in which obstructive azoospermia occurred after high inguinal varicocelectomy. The vas deferens was disrupted near the internal inguinal ring by fibrous tissue. A vasovasostomy was performed and semen parameters subsequently recovered.
October 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28696790/competitive-inhibition-of-amino-acid-transport-in-human-preovulatory-ovarian-follicles
#13
Maciej Jóźwik, Marcin Jóźwik, Anna Justyna Milewska, Frederick C Battaglia, Michał Jóźwik
To date we have yet to examine whether amino acid (AA) transport in human ovarian follicles is affected by competitive inhibition. In contrast, transplacental transfer of AAs in late-gestation sheep is characterized by reciprocal competition. This phenomenon has been described by algebraic equations of umbilical uptake of AAs based on maternal arterial concentrations. In the present translational study at a university teaching hospital, we verified whether these equations apply to the transport of AAs from blood to follicular fluid (FF) in human preovulatory follicles...
October 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28632990/shortening-gametes-co-incubation-time-improves-live-birth-rate-for-couples-with-a-history-of-fragmented-embryos
#14
Anne Le Bras, Laetitia Hesters, Vanessa Gallot, Cathie Tallet, Gerard Tachdjian, Nelly Frydman
Short gamete co-incubation (SGCO) consists in decreasing the duration of contact between oocytes and sperm from the standard overnight insemination (SOI) toward 2 hours. However, the effectiveness of this technique to improve in vitro fertilization and embryo transfer (IVF-ET) outcomes remains controversial. Our study was designed to evaluate the efficiency of SGCO in a poor prognosis population with a history of fragmented embryos defined by the presence of at least 50% of the embryos with more than 25% of cytoplasmic fragments...
October 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28609124/the-impact-of-laparoscopic-surgery-of-peritoneal-endometriosis-and-endometrioma-on-the-outcome-of-icsi-cycles
#15
Ismail Guler, Ahmet Erdem, Yuksel Oguz, Funda Cevher, Mehmet Firat Mutlu, Nuray Bozkurt, Mesut Oktem, Mehmet Erdem
Our objective was to assess the role of laparoscopic removal of ovarian endometriomas and ablation of peritoneal endometriosis on the outcome of intracytoplasmic sperm injection (ICSI) - Embryo Transfer cycles by comparing with the results of patients with untreated endometriomas and tubal factor without underlying endometriosis confirmed by laparoscopy. For this purpose, between 2002 and 2015, outcomes of 257 ICSI cycles of 150 patients, including 91 cycles of 48 patients in minimal endometriosis, 57 cycles of 25 patients in endometrioma removal, 65 cycles of 53 patients in non-operated endometrioma, and 44 cycles of 24 patients in tubal factor groups were retrospectively analyzed...
October 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28481628/microdeletions-at-dys448-and-dys387s1-associate-with-increased-risk-of-male-infertility
#16
Yanqing Li, Qiurong Zhao, Hai Liu
Male infertility affects many people of reproductive age. Diagnosis and therapies based on descriptive semen parameters have helped some of the infertility patients; however, further progress in reproductive therapy demands a better understanding of the molecular and genetic causes for male infertility. Although Y chromosome microdeletions have been a hot subject of genetic studies on male infertility, the relationship between male infertility and microdeletions at Y chromosome loci DYS448, DYS387, and DYS627 remains unclear...
October 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28436704/association-of-cat-262c-t-with-the-concentration-of-catalase-in-seminal-plasma-and-the-risk-for-male-infertility-in-algeria
#17
Nour El Houda Bousnane, Sadiq May, Mouloud Yahia, Abed Alkarem Abu Alhaija
Catalase (CAT) plays a central role in the protection of different cell types against the deleterious effects of hydrogen peroxide. In human, CAT is implicated in many physiological and pathological conditions including idiopathic male infertility. In this study we examined the association between CAT levels in seminal plasma with different sperm parameters and with CAT-262 C/T polymorphism and their risk for idiopathic male infertility in Algeria. Semen and blood samples were obtained from 111 infertile males and 104 fertile controls from the region of Eastern Algeria following informed consent...
October 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28771045/expression-patterns-and-changes-of-the-lcn2-gene-in-the-testes-of-induced-cryptorchidism-and-busulfan-treated-mice
#18
Zhenlong Kang, Na Qiao, Zhigang Tan, Zhaoxin Tang, Ying Li
Lipocalin-2 (LCN2) was known to play various roles in different type cells; however, little was known about the effect of LCN2 in male fertility. In this study, we aimed to explore the expression pattern of LCN2 with increasing age in mice, and to obtain insight into the role of LCN2 in mice testes by induced cryptorchidism and busulfan-treated infertility. In situ hybridization showed that LCN2 was localized primarily in Leydig cells, but was absent in Sertoli and germ cells. Its expression in testes exhibited an age-related increase from day 1 to 8 months, then reduced by the twelth month...
August 3, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28632452/the-effect-of-g-csf-on-infertile-women-undergoing-ivf-treatment-a-meta-analysis
#19
Jie Li, Sien Mo, Yang Chen
Evidence for the effect of granulocyte colony stimulating factor (G-CSF) on infertile women undergoing in vitro fertilization (IVF) remains inconsistent. This study aimed to evaluate the effectiveness of G-CSF on infertile women undergoing IVF. PubMed and EMBASE databases were searched before August 2016. Comparing the transvaginal perfusion of G-CSF and placebo or no treatment, the available studies were considered. The pooled risk ratio (RR) with 95% confidence intervals (CIs) was used in the analysis and six studies were included...
August 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28574782/rna-based-ovarian-cancer-research-from-a-gene-to-systems-biomedicine-perspective
#20
Esra Gov, Medi Kori, Kazim Yalcin Arga
Ovarian cancer remains the leading cause of death from a gynecologic malignancy, and treatment of this disease is harder than any other type of female reproductive cancer. Improvements in the diagnosis and development of novel and effective treatment strategies for complex pathophysiologies, such as ovarian cancer, require a better understanding of disease emergence and mechanisms of progression through systems medicine approaches. RNA-level analyses generate new information that can help in understanding the mechanisms behind disease pathogenesis, to identify new biomarkers and therapeutic targets and in new drug discovery...
August 2017: Systems Biology in Reproductive Medicine
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