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Systems Biology in Reproductive Medicine

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https://www.readbyqxmd.com/read/28085499/a-sperm-specific-proteome-scale-metabolic-network-model-identifies-non-glycolytic-genes-for-energy-deficiency-in-asthenozoospermia
#1
Arvand Asghari, Sayed-Amir Marashi, Naser Ansari-Pour
: About 15% of couples experience difficulty in conceiving a child, of which half of the cases are thought to be male-related. Asthenozoospermia, or low sperm motility, is one of the frequent types of male infertility. Although energy metabolism is suggested to be central to the etiology of asthenozoospermia, very few attempts have been made to identify its underlying metabolic pathways. Here, we reconstructed SpermNet, the first proteome-scale model of the sperm cell by using whole-proteome data and the mCADRE algorithm...
January 13, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28045561/age-related-changes-in-gene-expression-patterns-of-immature-and-aged-rat-primordial-follicles
#2
Vijayakumar Govindaraj, Harshini Krishnagiri, Payal Chakraborty, Madavan Vasudevan, A Jagannadha Rao
Women are born with millions of primordial follicles which gradually decrease with increasing age and this irreversible supply of follicles completely exhausts at menopause. The fertility capacity of women diminishes in parallel with aging. The mechanisms for reproductive aging are not fully understood. We have observed a decline in Brca1 mediated DNA repair in aging rat primordial follicles. To further understand the age-related molecular changes, we performed microarray gene expression analysis using total RNA extracted from immature (18 to 20 day old) and aged (400 to 450 day old) rat primordial follicles...
January 3, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28010131/predicting-the-clinical-outcome-of-icsi-by-sperm-head-vacuole-examination
#3
Khaled Pocate-Cheriet, Ilan Heilikman, Raphael Porcher, Virginie Barraud-Lange, Nathalie Sermondade, Charlene Herbemont, Jean Philippe Wolf, Christophe Sifer
: To assess whether high magnification sperm head vacuole examination (SHVE) and/or standard sperm morphology assessment can predict ICSI outcomes in terms of fertilization, embryo quality, and delivery rates, a prospective observational bicentric study was conducted in two publicly funded assisted reproductive technology (ART) units in France between January and July of 2012. A total of 111 ICSI cycles for exclusively male infertility factors were included. A Spearman's correlation test was performed to validate SHVE reproducibility between the ART units...
December 23, 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/27983873/leptin-and-leptin-receptor-polymorphisms-in-fertile-and-infertile-men
#4
Saeid Khosropour, Maryam Hamidi, Amir Fattahi, Iraj Khodadadi, Manoochehr Karami, Mohammad Fazilati, Asad Vaisi-Raygani, Heidar Tavilani
: The association of leptin (LEP) -2548G/A and/or leptin receptor (LEPR) Gln223Arg polymorphisms with male infertility and plasma FSH, LH, and testosterone (T) levels was examined. The genotypes and allele frequency distributions of LEP -2548G/A and LEPR Gln223Arg polymorphisms were investigated in 150 fertile and 150 infertile men by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Also, plasma levels of FSH, LH, and T were measured using commercial ELISA kits...
December 16, 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/27973917/mitochondrial-variations-in-the-mt-nd4-and-mt-tl1-genes-are-associated-with-male-infertility
#5
Feng Ni, Yun Zhou, Wen-Xiang Zhang, Xue-Mei Wang, Xiao-Min Song, Hong Jiang
: Mitochondrial gene mutations have been reported to be associated with sperm motility and the quality of semen. The aim of this study was to investigate whether the two mitochondrial genes (MT-ND4 and MT-TL1) are involved in Chinese male infertility. A total of 97 asthenospermia patients and 80 fertile controls were recruited in this case-control study. Genomic DNA were extracted from the sperm of all participants. Two mitochondrial DNA genes (MT-ND4 and MT-TL1) were amplified by using polymerase chain reaction (PCR) with the gene-specific primers and sequenced on an ABI 3730XL DNA sequencer...
December 14, 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/27874292/granulocyte-colony-stimulating-factor-treatment-of-resistant-thin-endometrium-in-women-with-frozen-thawed-blastocyst-transfer
#6
Michał Kunicki, Krzysztof Łukaszuk, Joanna Liss, Patrycja Skowrońska, Joanna Szczyptańska
: The aim of the study was to assess the granulocyte-colony stimulating factor (G-CSF) effect on unresponsive thin (<7 mm) endometrium in women undergoing frozen-thawed embryo transfer at the blastocyst stage. A total of 62 women with thin unresponsive endometrium were included in the study, of which, 29 received a G-CSF infusion and 33 who opted out of the study served as controls. Patients in both groups had similar endometrial thickness at the time of the initial evaluation: 6.50 mm (5...
November 22, 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/27870555/initiative-for-standardization-of-reporting-genetics-of-male-infertility
#7
Eva Traven, Ana Ogrinc, Tanja Kunej
The number of publications on research of male infertility is increasing. Technologies used in research of male infertility generate complex results and various types of data that need to be appropriately managed, arranged, and made available to other researchers for further use. In our previous study, we collected over 800 candidate loci for male fertility in seven mammalian species. However, the continuation of the work towards a comprehensive database of candidate genes associated with different types of idiopathic human male infertility is challenging due to fragmented information, obtained from a variety of technologies and various omics approaches...
November 21, 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/27802063/in-silico-analysis-of-candidate-proteins-sharing-homology-with-streptococcus-agalactiae-proteins-and-their-role-in-male-infertility
#8
Rajeshwari Parida, Luna Samanta
: Leukocytospermia is a physiologic condition defined as human semen with a leukocyte count of >1 x 10(6) cells/ml that is often correlated with male infertility. Moreover, bacteriospermia has been associated with leukocytospermia ultimately leading to male infertility. We have found that semen samples with >1 x 10(6)/ml leukocytes and/or bacteriospermia have oxidative predominance as evidenced by augmented protein carbonyl and lipid peroxidation status of the semen which is implicated in sperm dysfunction...
November 1, 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/27831849/2016-systems-biology-in-reproductive-medicine-selected-highlights
#9
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/27792396/dietary-supplementation-with-docosahexaenoic-acid-dha-improves-seminal-antioxidant-status-and-decreases-sperm-dna-fragmentation
#10
Juan Carlos Martínez-Soto, Joan Carles Domingo, Begoña Cordobilla, María Nicolás, Laura Fernández, Pilar Albero, Joaquín Gadea, José Landeras
The purpose of this study was to evaluate the effect of docosahexaenoic acid (DHA) dietary supplementation on semen quality, fatty acid composition, antioxidant capacity, and DNA fragmentation. In this randomized, double blind, placebo-controlled, parallel-group study, 74 subjects were recruited and randomly assigned to either the placebo group (n=32) or to the DHA group (n=42) to consume three 500-mg capsules of oil per day over 10 weeks. The placebo group received 1,500 mg/day of sunflower oil and the DHA group 1,500 mg/day of DHA-enriched oil...
December 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/27726449/single-nucleotide-polymorphisms-of-usp26-in-azoospermic-men
#11
Alice Luddi, Laura Crifasi, Antonella Quagliarello, Laura Governini, Vincenzo De Leo, Paola Piomboni
Some studies have focused on the association between male infertility and single nucleotide polymorphisms (SNPs) in the ubiquitin-specific protease 26 (USP26) gene, but the results are controversial. In this case-control study including both normozoospermic men and patients with nonobstructive azoospermia, we analyzed both the entire coding region and 5' and 3' untranslated regions of USP26 in order to identify genetic variants in this gene to investigate the role of USP26 on spermatogenesis. We reported variations in the USP26 gene sequence in 82% of azoospermic and in 50% normospermic men...
December 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/27690645/augmenting-effect-of-vitrification-on-lipid-peroxidation-in-mouse-preantral-follicle-during-cultivation-modulation-by-coenzyme-q10
#12
Roya Hedayati Kashka, Saeed Zavareh, Taghi Lashkarbolouki
Cryopreservation-induced oxidative stress (OS) may lead to lipid peroxidation, which may be responsible for decreased cell survival rate. Coenzyme Q10 (CoQ10) as a potent antioxidant may improve cell viability by neutralizing OS. In this study, oxidative lipid injury following the vitrification of preantral follicles was investigated. The effects of CoQ10 treatment on the malondialdehyde (MDA) levels, lipid peroxidation products, and activities of enzymatic and nonenzymatic antioxidants of vitrified preantral follicles were also studied...
December 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/27686340/functional-assessment-for-elimination-of-mismatches-in-nuclear-and-whole-cell-extracts-obtained-from-mouse-and-human-blastocysts
#13
Pinar Tulay, Souraya Jaroudi, Alpesh Doshi, Sioban B SenGupta
Preimplantation embryos may have an increased risk of having mismatches due to the rates of cell proliferation and DNA replication. Elimination of mismatches in human gametes and embryos has not been investigated. In this study we developed a sensitive functional assay to examine the repair or elimination of mismatches in both commercially available cell extracts and extracts obtained from preimplantation embryos. Heteroduplex molecules were constructed using synthetic oligonucleotides. Efficiency of the repair of mismatches was semi-quantitatively analysed by exposure to nuclear/whole cell extracts (as little as 2...
December 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/27646677/improving-icsi-a-review-from-the-spermatozoon-perspective
#14
Mara Simopoulou, Laertis Gkoles, Panagiotis Bakas, Polina Giannelou, Theodoros Kalampokas, Konstantinos Pantos, Michael Koutsilieris
: Intracytoplasmic sperm injection (ICSI) is the most frequently applied method for fertilization making the process of identifying the perfect spermatozoon fundamental. Herein we offer a critical and thorough presentation on the techniques reported regarding (i) handling and preparing semen samples, (ii) identifying and 'fishing' spermatozoa, and (iii) improving key factors, such as motility for a successful ICSI practice. These approaches are suggested to make the process easier and more effective especially in atypical and challenging circumstances...
December 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/27611370/seasonal-variation-of-human-sperm-cells-among-4-422-semen-samples-a-retrospective-study-in-turkey
#15
Runa Ozelci, Saynur Yılmaz, Berna Dilbaz, Funda Akpınar, Derya Akdag Cırık, Serdar Dilbaz, Aslı Ocal
: We aimed to assess the possible presence of a seasonal pattern in three parameters of semen analysis: sperm concentration, morphology, and motility as a function of the time of ejaculation and sperm production (spermatogenesis) in normal and oligozoospermic men. This retrospective study included a consecutive series of 4,422 semen samples that were collected from patients as a part of the basic evaluation of the infertile couples attending the Reproductive Endocrine Outpatient Clinic of a tertiary women's hospital in Ankara, Turkey, between January 1, 2012 and December 31, 2013...
December 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/27598006/laser-assisted-zona-hatching-does-not-lead-to-immediate-impairment-in-human-embryo-quality-and-metabolism
#16
Shubhashree Uppangala, Fiona D'Souza, Shivanand Pudakalakatti, Hanudatta S Atreya, Keyur Raval, Guruprasad Kalthur, Satish Kumar Adiga
: Laser assisted zona hatching (LAH) is a routinely used therapeutic intervention in assisted reproductive technology for patients with poor prognosis. However, results are not conclusive in demonstrating the benefits of zona hatching in improving the pregnancy rate. Recent observations on LAH induced genetic instability in animal embryos prompted us to look into the effects of laser assisted zona hatching on the human preimplantation embryo quality and metabolic uptake using high resolution nuclear magnetic resonance (NMR) technology...
December 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/27586844/the-maturation-of-murine-spermatozoa-membranes-within-the-epididymis-a-computational-biology-perspective
#17
Nicola Bernabò, Raffaele Di Agostino, Alessandra Ordinelli, Mauro Mattioli, Barbara Barboni
To become fertile, mammalian spermatozoa require completing a complex biochemical maturation that begins in the testis and ends within the female oviduct. Here, we paid attention to the events occurring at the membrane level during the epididymal transit. Indeed, in the epididymis, the molecular composition and the physical-chemical proprieties of sperm membranes markedly change, with functional cross talking among the spermatozoa, the epithelium, and the luminal content (particularly the epididymosomes). To study this process, we undertook a biological networks study, representing the involved molecules as nodes and their interactions as links...
October 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/27560353/chromosomal-polymorphic-variants-increase-aneuploidies-in-male-gametes-and-embryos
#18
Ruth Morales, Belén Lledó, José A Ortiz, Jorge Ten, Joaquin Llácer, Rafael Bernabeu
UNLABELLED: Chromosomal polymorphisms involve heterochromatic regions and occur in the general population. However, previous studies have reported a higher incidence of these variants in infertile patients. The aim of this study was to examine the relationship between polymorphic variants and infertility and their association with aneuploidies in male gametes and embryos. We retrospectively considered 1,551 cytogenetic studies involving infertile patients (study group; n=866) and oocyte/sperm donors as the control group (n=685)...
October 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/27487446/thiol-oxidation-by-nitrosative-stress-cellular-localization-in-human-spermatozoa
#19
María E Cabrillana, Pamela Uribe, Juana V Villegas, Juan Álvarez, Raúl Sánchez, Miguel W Fornés
UNLABELLED: Peroxynitrite is a highly reactive nitrogen species and when it is generated at high levels it causes nitrosative stress, an important cause of impaired sperm function. High levels of peroxynitrite have been shown to correlate with decreased semen quality in infertile men. Thiol groups in sperm are mainly found in enzymes, antioxidant molecules, and structural proteins in the axoneme. Peroxynitrite primarily reacts with thiol groups of cysteine-containing proteins. Although it is well known that peroxynitrite oxidizes sulfhydryl groups in sperm, the subcellular localization of this oxidation remains unknown...
October 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/27487396/sperm-chromatin-maturity-and-integrity-correlated-to-zygote-development-in-icsi-program
#20
Asmarinah, Ahmad Syauqy, Liya Agustin Umar, Silvia Werdhy Lestari, Eliza Mansyur, Andon Hestiantoro, Agnieszka Paradowszka-Dogan
UNLABELLED: This study aimed to evaluate sperm chromatin maturity and integrity of that injected into good-quality oocytes in an in vitro fertilization-intra cytoplasmic sperm injection (IVF-ICSI) program. A cut-off value of sperm chromatin maturity and integrity was developed as a function of their correlation to the zygote development, i.e., embryo formation and cleavage rate. The study assessed sperm chromatin maturity using aniline blue (AB) staining, whereas toluidine blue (TB) staining was used to assess sperm chromatin integrity...
October 2016: Systems Biology in Reproductive Medicine
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