journal
MENU ▼
Read by QxMD icon Read
search

Journal of Breath Research

journal
https://www.readbyqxmd.com/read/28492183/evaluation-of-sup-13-sup-co-sub-2-sub-enrichment-values-obtained-with-an-oral-breath-test-under-conditions-of-impaired-gastric-functioning-sup-sup
#1
Josef Vogt, Ulrich Wachter, Peter Radermacher, Michael Georgieff, Daniel König, Walter Fabinski, Eberhard Barth
Gastric emptying can be assessed by an oral administration of a <sup>13</sup>C-labeled substrate and its response in the expiratory release of the oxidation product <sup>13</sup>CO<sub>2</sub>. Impaired gut function, reflected e.g. in an intolerance against enteral nutrition may delay or discontinue gastric emptying, potentially leading to multiple peaks in the time profile of expiration. The resulting profile cannot be analyzed by the usual data evaluation that is based on a 'beta-exponential' function (<i>BEX</i>)...
May 11, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28473668/molecular-breath-analysis-identifies-the-breathprint-of-renal-failure
#2
Sevag Demirjian, Kelly M Paschke, Xiaofeng Wang, David Grove, Robert Heyka, Raed Dweik
Many uremic solutes retained in chronic kidney disease are volatile, and can be detected by breath testing. We compared the exhaled breath of subjects with end stage renal disease (ESRD) to healthy volunteers to identify volatile compounds that can serve as a potential breathprint for renal failure. We analyzed the exhaled breath of 86 ESRD subjects and 25 healthy volunteers using selected-ion flow-tube mass spectrometry (SIFT-MS). Using a random forests classification model, we identified three known volatiles (2-propanol, ammonia, acetaldehyde) and two unknown volatiles (O2+50, NO+76) that were highly significant for discriminating individuals with renal failure from individuals without renal failure (C statistic > 0...
May 5, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28439048/faecal-volatile-organic-compounds-analysis-using-field-asymmetric-ion-mobility-spectrometry-non-invasive-diagnostics-in-paediatric-inflammatory-bowel-disease
#3
Nora van Gaal, Rozanne Lakenman, James Covington, Richard Savage, Evelien de Groot, Marije Bomers, Marc Benninga, Chris Mulder, Nanne de Boer, Tim de Meij
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), remains challenging to diagnose. Diagnostic work up carries a high burden, especially in paediatric patients, due to invasive endoscopic procedures. IBD is associated with alterations in intestinal microbiota composition. Faecal volatile organic compounds (VOCs) reflect gut microbiota composition. Aim of this study was to assess the diagnostic accuracy of faecal VOC profiling as non-invasive diagnostic biomarker for paediatric IBD...
April 25, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28424429/the-volatile-molecule-signature-of-four-mycobacteria-species
#4
Theodore Mellors, Christiaan Rees, Wendy Wieland-Alter, C Fordham von Reyn, Jane E Hill
Mycobacteria are the leading cause of death from infectious disease worldwide and limitations in current diagnostics are hampering control efforts. In recent years, the use of small volatile molecules as diagnostic biomarkers for mycobacteria has shown promise for use in the rapid analysis of in vitro cultures as well as ex vivo diagnosis using breath or sputum. In this study, 18 strains from four mycobacteria species (Mycobacterium avium, M. bovis BCG, M. intracellulare and M. xenopi) were analyzed for the first time using two-dimensional gas chromatography time-of-flight mass spectrometry (GC×GC-TOFMS)...
April 20, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28416775/volatile-organic-compounds-in-gastrointestinal-stromal-tumour-tissue-originating-from-patient-derived-xenografts
#5
Renata Wawrzyniak, Agnieszka Woźniak, Yemarshet Gebreyohannes, Bartosz Dykcik, Patrick Schöffski, Michal Markuszewski
Gastrointestinal stromal tumours (GIST) are the most common mesenchymal neoplasms of the gastrointestinal tract, localized mainly in the stomach or small intestine. The metabolomic signature of GIST signature associated with various mutations in KIT gene remains undiscovered and unexplored. The main aim of this pilot study was to determine and compare metabolomic profiles in GIST xenograft models with different genetic background. Metabolomic profiling using gas chromatography coupled with mass spectrometry followed by both univariate and multivariate statistical analyses was applied to select metabolites which differentiate the GIST models studied...
April 18, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28373602/data-analysis-of-electronic-nose-technology-in-lung-cancer-generating-prediction-models-by-means-of-aethena
#6
Sharina Kort, Marjolein Brusse-Keizer, Jan-Willem Gerritsen, Job van der Palen
INTRODUCTION: Only 15% of lung cancer cases present with potentially curable disease. Therefore, there is large interest in a fast, non-invasive tool to detect lung cancer earlier. Exhaled breath analysis by electronic nose technology measures volatile organic compounds (VOC's) in exhaled breath which are associated with lung cancer. METHODS: The diagnostic accuracy of the Aeonose™ is currently being studied in a multi-centre, prospective study in 210 subjects suspected for lung cancer, where approximately half will have a confirmed diagnosis and the other half will have a rejected diagnosis of lung cancer...
April 4, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28294105/breath-acetone-as-a-potential-marker-in-clinical-practice
#7
Vera Ruzsanyi, Miklós Kalapos
In recent decades, two facts have changed the opinion of researchers about the function of acetone in humans. Firstly, it has turned out that acetone cannot be regarded as simply a waste product of metabolism, because there are several pathways in which acetone is produced or broken down. Secondly, methods have emerged making possible its detection in exhaled breath, thereby offering an attractive alternative to investigation of blood and urine samples. From a clinical point of view the measurement of breath acetone levels are important, but there are limitations to its wide application...
March 15, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28440225/observation-of-nonanoic-acid-and-aldehydes-in-exhaled-breath-of-patients-with-lung-cancer
#8
L Callol-Sanchez, M A Munoz-Lucas, O Gomez-Martin, J A Maldonado-Sanz, C Civera-Tejuca, C Gutierrez-Ortega, G Rodriguez-Trigo, J Jareno-Esteban
Lung cancer (LC) is the leading cause of cancer death in men and the second leading cause in women worldwide. The use of low-dose computed tomography in early diagnosis was shown to reduce mortality by 20% with a median follow-up time of 6.5 years. In order to increase profitability and reduce radiation risks and costs, exhaled biomarkers could serve to help establish narrower inclusion criteria. The aim of this study was to identify new, well-founded volatile organic compounds in exhaled breath which distinguish LC patients from chronic obstructive pulmonary disease (COPD) patients and healthy subjects...
April 25, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28397711/volatile-organic-compounds-in-exhaled-breath-are-independent-of-systemic-inflammatory-syndrome-caused-by-intravenous-lipopolysaccharide-infusion-in-humans-results-from-an-experiment-in-healthy-volunteers
#9
Anna L Peters, Marije G Gerritsen, Paul Brinkman, Koos A H Zwinderman, Alexander P J Vlaar, Lieuwe D Bos
Systemic inflammatory response syndrome (SIRS) is observed during critical illness in most patients. It is defined by a clinical definition. The composition of volatile organic compounds (VOCs) in exhaled breath may change during SIRS and may thus serve as a diagnostic tool. We investigated whether exhaled breath VOCs can serve as biomarker for SIRS in a human model of endotoxemia. Eighteen healthy volunteers received 2 ng Eschericia coli lipopolysaccharide (LPS) kg(-1) body weight intravenously. Venous blood and exhaled breath were collected before infusion of LPS and every 2 h thereafter, up to 8 h after infusion...
April 11, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28260695/non-invasive-breath-monitoring-with-enose-does-not-improve-glucose-diagnostics-in-critically-ill-patients-in-comparison-to-continuous-glucose-monitoring-in-blood
#10
Jan Hendrik Leopold, Lieuwe D J Bos, Camilla Colombo, Peter J Sterk, Marcus J Schultz, Ameen Abu-Hanna
Continuous glucose monitoring (CGM) can be beneficial in critically ill patients. Current CGM devices rely on subcutaneous or blood plasma glucose measurements and consequently there is an increased risk of infections and the possibility of loss of blood with each measurement. A potential method to continuously and non-invasively measure blood glucose levels is using exhaled breath. A correlation between blood glucose levels and volatile organic compounds (VOCs) in the exhaled breath was already reported. VOCs can be analyzed continuously using a so-called electronic nose (eNose)...
April 7, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28244881/oral-or-nasal-breathing-real-time-effects-of-switching-sampling-route-onto-exhaled-voc-concentrations
#11
Pritam Sukul, Peter Oertel, Svend Kamysek, Phillip Trefz
There is a need for standardisation in sampling and analysis of breath volatile organic compounds (VOCs) in order to minimise ubiquitous confounding effects. Physiological factors may mask concentration changes induced by pathophysiological effects. In humans, unconscious switching of oral and nasal breathing can occur during breath sampling, which may affect VOC patterns. Here, we investigated exhaled VOC concentrations in real-time while switching breathing routes. Breath from 15 healthy volunteers was analysed continuously by proton transfer reaction time-of-flight mass spectrometry during paced breathing (12 breaths min(-1))...
March 21, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28220034/exhaled-and-nasal-nitric-oxide-in-relation-to-lung-function-blood-cell-counts-and-disease-characteristics-in-cystic-fibrosis
#12
Christina Krantz, Christer Janson, Annika Hollsing, Kjell Alving, Andrei Malinovschi
BACKGROUND: Patients with cystic fibrosis (CF) have similar or lower exhaled nitric oxide (FeNO) and lower nasal nitric oxide (nNO) levels than controls. There are divergent results on alveolar NO (CalvNO) concentrations in relation to CF. There are inconsistent results on correlation between different nitric oxide parameters and lung function and inflammation in CF. AIM: To compare FeNO, CalvNO and nNO levels between subjects with CF, asthma and healthy controls and to study whether these parameters are related to lung function, blood cell counts or clinical characteristics in CF patients...
March 20, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28301330/focus-issue-on-the-cellular-origin-of-volatile-metabolites
#13
Wojciech Filipiak, Jane Hill
No abstract text is available yet for this article.
March 16, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28134131/design-and-characterization-of-a-cough-simulator
#14
Bo Zhang, Chao Zhu, Zhiming Ji, Chao-Hsin Lin
Expiratory droplets from human coughing have always been considered as potential carriers of pathogens, responsible for respiratory infectious disease transmission. To study the transmission of disease by human coughing, a transient repeatable cough simulator has been designed and built. Cough droplets are generated by different mechanisms, such as the breaking of mucus, condensation and high-speed atomization from different depths of the respiratory tract. These mechanisms in coughing produce droplets of different sizes, represented by a bimodal distribution of 'fine' and 'coarse' droplets...
February 23, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28140379/factors-that-influence-the-volatile-organic-compound-content-in-human-breath
#15
L Blanchet, A Smolinska, A Baranska, E Tigchelaar, M Swertz, A Zhernakova, J W Dallinga, C Wijmenga, F J van Schooten
BACKGROUND: Thousands of endogenous and exogenous volatile organic compounds (VOCs) are excreted in each breath. Inflammatory and deviant metabolic processes affect the level of endogeneous VOCs, which can serve as specific biomarkers for clinical diagnosis and disease monitoring. Important issues that still need to be tackled are related to potential confounding factors like gender and age and endogenous and exogenous factors, like f.i. smoking. METHODS: The aim of this study was to systematically access the effect of endogenous and exogenous factors on VOC composition of exhaled breath...
February 22, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28104897/optimal-flow-rate-sampling-designs-for-studies-with-extended-exhaled-nitric-oxide-analysis
#16
Noa Molshatski, Sandrah P Eckel
INTRODUCTION: The fractional concentration of exhaled nitric oxide (FeNO) is a biomarker of airway inflammation. Repeat FeNO maneuvers at multiple fixed exhalation flow rates (extended NO analysis) can be used to estimate parameters quantifying proximal and distal sources of NO in mathematical models of lower respiratory tract NO. A growing number of studies use extended NO analysis, but there is no official standard flow rate sampling protocol. In this paper, we provide information for study planning by deriving theoretically optimal flow rate sampling designs...
February 22, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28220762/drug-detection-in-breath-non-invasive-assessment-of-illicit-or-pharmaceutical-drugs
#17
Phillip Trefz, Svend Kamysek, Patricia Fuchs, Pritam Sukul, Jochen Schubert, Wolfram Miekisch
Breath analysis not only holds great potential for the development of new non-invasive diagnostic methods, but also for the identification and follow up of drug levels in breath. This is of interest for both, forensic and medical science. On the one hand, the detection of drugs of abuse in exhaled breath - similar to the well-known breath alcohol tests - would be highly desirable as an alternative to blood or urine analysis in situations such as police controls for drugged driving. The noninvasive detection of drugs and their metabolites is thus of great interest in forensic science, especially since marijuana is becoming legalized in certain parts of the U...
February 21, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28212110/the-impact-of-chewing-gum-on-halitosis-parameters-a-systematic-review
#18
Francisco Wilker Mustafa Gomes Muniz, Stephanie Anagnostopoulos Friedrich, Carina Folgearini Silveira, Cassiano Kuchenbecker Rösing
This study aimed to analyze the impact of chewing gum on halitosis parameters. Three databases were searched with the following focused question: 'Can chewing gum additionally reduce halitosis parameters, such as organoleptic scores and volatile sulfur compounds (VSC), when compared to a control treatment'? Controlled clinical trials presenting at least two halitosis measurements (organoleptic scores and/or VSC) were included. Ten studies were included, and different active ingredients were used. One study was performed using a chewing gum without any active ingredient...
February 17, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28102831/biomarkers-in-adult-asthma-a-systematic-review-of-8-isoprostane-in-exhaled-breath-condensate
#19
Adam M Peel, Christina-Jane Crossman-Barnes, Jonathan Tang, Stephen J Fowler, Gwyneth A Davies, Andrew M Wilson, Yoon K Loke
OBJECTIVES: We aimed to assess the evidence for the use of 8-isoprostane in exhaled breath condensate (EBC) as a biomarker in adult asthma. DESIGN: A systematic review and meta-analysis of EBC 8-isoprostane. METHODS: We searched a number of online databases (including PubMed, Embase and Scopus) in January 2016. We included studies of adult non-smokers with EBC collection and asthma diagnosis conducted according to recognised guidelines. We aimed to pool data using random effects meta-analysis and assess heterogeneity using I (2)...
February 10, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28165332/exhaled-breath-and-oral-cavity-vocs-as-potential-biomarkers-in-oral-cancer-patients
#20
Marcos Bouza, Jesus Gonzalez-Soto, Rosario Pereiro, Juan Carlos de Vicente, Alfredo Sanz-Medel
Corporal mechanisms attributed to cancer, such as oxidative stress or the action of cytochrome P450 enzymes, seem to be responsible of the generation of a variety of volatile organic compounds (VOCs) that could be used as non-invasive diagnosis biomarkers. The present work presents an attempt of using VOCs from exhaled breath and oral cavity air as biomarkers for oral squamous cell carcinoma (OSCC) patients. 52 breath samples were collected (3 L Tedlar bags) from 26 OSCC patients and 26 cancer-free controls...
February 6, 2017: Journal of Breath Research
journal
journal
41860
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"