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Journal of Breath Research

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https://www.readbyqxmd.com/read/29984709/sensitive-spectroscopic-breath-analysis-by-water-condensation
#1
Kiran Sankar Maiti, Michael Lewton, Ernst Fill, Alexander Apolonskiy
Breath analysis has a high potential for becoming an important clinical diagnosis method due to its friendly and non-invasive way of sample collection. Hundreds of endogenous trace gases (volatile organic compounds (VOCs)) are present in breath, representing different metabolic processes of the body. They are not only characteristic for a person, their age, sex, habit etc., but also specific to different kinds of disease. VOCs, related to diseases serve as biomarkers for clinical diagnostics and disease monitoring...
July 9, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29984708/determination-of-carbonyl-compounds-in-exhaled-breath-by-on-sorbent-derivatization-coupled-with-thermal-desorption-and-gas-chromatography-tandem-mass-spectrometry
#2
Tommaso Lomonaco, Andrea Romani, Silvia Ghimenti, Denise Biagini, Francesca Giuseppa Bellagambi, Massimo Onor, Pietro Salvo, Roger Fuoco, Fabio Di Francesco
A reliable method for the determination of carbonyl compounds in exhaled breath based on on-sorbent derivatization coupled with thermal desorption and gas chromatography-tandem mass spectrometry is described. The analytical performances were optimized for a mixture of C2-C9 aldehydes and C3-C9 ketones, particularly interesting for clinical applications, by using an internal standard and applying a 23 full factorial design. A volume of sample (250 mL) was loaded at 50 mL/min into a Tenax GR sorbent tube containing 130 nmol of O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine hydrochloride...
July 9, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29967309/short-term-benefit-of-smoking-cessation-along-with-glycopirronium-on-lung-function-and-respiratory-symptoms-in-mild-copd-patients-a-retrospective-study
#3
Aldo Pezzuto, Marco Stellato, Giovanna Catania, Calogero Mazzara, Sara Tonini, Marco Caricato, Pierifilippo Crucitti, Giuseppe Tonini
Introduction 
 Tobacco smoke is the leading cause of chronic obstructive pulmonary disease (COPD). Smoking cessation can change the natural history of COPD as we know from the GOLD guidelines. Little is known about the short-term clinical and functional effects of smoking cessation treatment combined with anti-muscarinic bronchodilators.
 Objective
 To determine if quit smoking combined with the use of new long-acting muscarinic antagonist bronchodilator (LAMA) can improve lung function tests and respiratory symptoms compared with the only use of bronchodilator without smoking cessation...
July 3, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29947332/efficacy-of-probiotics-clinical-and-microbial-parameters-of-halitosis
#4
Athina Christina Georgiou, Marja L Laine, Dong Mei Deng, Bernd W Brandt, Cor van Loveren, Xanthippi Dereka

 Background & Aim: Halitosis is defined as an offensive breath odour of whatever source and therefore may affect a person's social interactions. Intra-oral halitosis is a result of bacterial activity. Therefore, probiotics may offer an appropriate and biological solution as a part of the therapy of intra-oral halitosis. The aim of this systematic review was to study the effect of the administration of probiotics alone or as an adjunct to other treatments on level of halitosis as measured by volatile sulphur compounds (VSC) levels, organoleptic scores (ORG) or hydrogen sulphide, methyl-mercaptan and dimethyl-sulphide levels...
June 27, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29943733/the-characterisation-of-hepatic-mitochondrial-function-in-patients-with-non-alcoholic-fatty-liver-disease-nafld-using-the-sup-13-sup-c-ketoisocaproate-breath-test
#5
Paul R Afolabi, Eleonora Scorletti, Debbie E Smith, Amal A Almehmadi, Philip C Calder, Christopher D Byrne
Hepatic mitochondrial function (HMF) assessed by the <sup>13</sup>C-ketoisocaproate breath test (<sup>13</sup>C-KICA BT) has been previously shown to be significantly associated with the severity of biopsy proven non-alcoholic fatty liver disease (NAFLD). However, it is uncertain whether any perturbation in HMF relates specifically to severity of liver disease or factors associated with metabolic syndrome within non-alcoholic fatty liver disease (NAFLD)...
June 26, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29910196/identification-of-i-mycobacterium-tuberculosis-i-using-volatile-biomarkers-in-culture-and-exhaled-breath
#6
Theodore Robert Mellors, Mavra Nasir, Flavio Antonio Franchina, Agnieszka Smolinska, Lionel Blanchet, JoAnne Flynn, Jaime A Tomko, Melanie Joy O'Malley, Charles A Scanga, Philana Ling Lin, Jeffrey Wagner, Jane E Hill
In this pilot study, volatile molecules produced by cultures of Mycobacterium tuberculosis were evaluated to determine whether they could be used to discriminate between uninfected and M. tuberculosis-infected macaques. Thirty seven of the culture biomarkers were detectable in macaque breath and were shown to discriminate between uninfected and infected animals with an area under the curve (AUC) of 87%. An AUC of 98% was achieved when using the top 38 discriminatory molecules detectable in breath. We report two newly discovered volatile biomarkers, not previously associated with M...
June 18, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29900878/versatile-set-up-for-non-invasive-i-in-vitro-i-analysis-of-headspace-vocs
#7
Selina Traxler, Ann-Christin Bischoff, Phillip Trefz, Jochen Schubert, Wolfram Miekisch
Volatile organic compound (VOC) profiles emitted in trace concentrations from bacteria or cells has gained increasing importance over the last decades. Analysis of VOCs in the headspace does not interfere with in vitro systems and, therefore, offers new options for noninvasive monitoring of cultures. Currently there is not any available standardized in-vitro sampling system which considers effects of dilution and contamination onto ppbV to pptV VOC concentrations during. In this study a new in-vitro system for online and offline headspace measurement of biological cultures was designed...
June 14, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29893713/-i-ex-vivo-i-emission-of-volatile-organic-compounds-from-gastric-cancer-and-non-cancerous-tissue
#8
Paweł Mochalski, Marcis Leja, Evita Gasenko, Roberts Skapars, Daiga Santare, Armands Sivins, Dan Erik Aronsson, Clemens Ager, Carsten Jaeschke, Gidi Shani, Jan Mitrovics, Christopher A Mayhew, Hossam Haick
The presence of certain volatile organic compounds (VOCs) in the breath of patients with gastric cancer has been reported by a number of research groups; however, the source of these compounds remains controversial. Comparison of VOCs emitted from gastric cancer tissue to those emitted from non-cancerous tissue would help in understanding which of the VOCs are associated with gastric cancer and provide a deeper knowledge on their generation. Gas chromatography with mass spectrometric detection (GC-MS) coupled with head-space needle trap extraction (HS-NTE) as the pre-concentration technique, was used to identify and quantify VOCs released by gastric cancer and non-cancerous tissue samples collected from 41 patients during surgery...
June 12, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29735804/volatile-fingerprinting-of-i-pseudomonas-aeruginosa-i-and-respiratory-syncytial-virus-infection-in-an-i-in-vitro-i-cystic-fibrosis-co-infection-model
#9
Giorgia Purcaro, Christiaan Rees, Jeffrey A Melvin, Jennifer M Bomberg, Jane E Hill
Volatile molecules in exhaled breath represent potential biomarkers in the setting of infectious diseases, particularly those affecting the respiratory tract. In particular, Pseudomonas aeruginosa is a critically-important respiratory pathogen in specific subsets of the population, such as those with cystic fibrosis. Infections caused by P. aeruginosa can be particularly problematic when co-infection with respiratory syncytial virus (RSV) occurs, as this is correlated with the establishment of chronic P. aeruginosa infection...
May 8, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29771243/breath-volatile-organic-compounds-of-lung-transplant-recipients-with-and-without-chronic-lung-allograft-dysfunction
#10
L Küppers, O Holz, S Schuchardt, J Gottlieb, J Fuge, M Greer, J M Hohlfeld
INTRODUCTION: Chronic lung allograft dysfunction with its clinical correlative of bronchiolitis obliterans syndrome (BOS) remains the major limiting factor for long-term graft survival. Currently there are no established methods for the early diagnosis or prediction of BOS. To assess the feasibility of breath collection as a non-invasive tool and the potential of breath volatile organic compounds (VOC) for the early detection of BOS, we compared the breath VOC composition between transplant patients without and different stages of BOS...
June 20, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29771240/power-efficient-self-cleaning-hydrophilic-condenser-surface-for-portable-exhaled-breath-condensate-ebc-metabolomic-sampling
#11
Konstantin O Zamuruyev, Alexander J Schmidt, Eva Borras, Mitchell M McCartney, Michael Schivo, Nicholas J Kenyon, Jean-Pierre Delplanque, Cristina E Davis
In this work, we present a hydrophilic self-cleaning condenser surface for the collection of biological and environmental aerosol samples. The condenser is installed in a battery-operated hand-held breath sampling device. The device performance is characterized by the collection and analysis of exhaled breath samples from a group of volunteers. The exhaled breath condensate is collected on a subcooled condenser surface, transferred into a storage vial, and its chemical content is analyzed using mass spectrometric methods...
June 8, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29760294/breath-profiles-of-children-on-ketogenic-therapy
#12
Veronika Ruzsányi, Miklós Péter Kalapos, Christine Schmidl, Daniela Karall, Sabine Scholl-Bürgi, Matthias Baumann
Ketogenic diets (KDs) were initially introduced to clinical practices as alimentary approaches with the aim to control drug-resistant epilepsies. Over the decades, a large and growing body of research has addressed the antiseizure effect of various KDs, and worked out KD-based dietary regimens, including their acting factors and modes of action. KDs have also appeared in weight loss therapies. Therapy control, particularly at initiation, happens through regular blood analysis and control of urine ketone levels...
June 8, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29724960/cluster-analysis-on-breath-print-of-newly-diagnosed-copd-patients-effects-of-therapy
#13
Simone Scarlata, Panaiotis Finamore, Simona Santangelo, Gilda Giannunzio, Giorgio Pennazza, Simone Grasso, Marco Santonico, Raffaele Antonelli Incalzi
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a highly heterogeneous disease and airflow limitation and symptoms only partially capture such heterogeneity. Since COPD is known to affect the production of volatile organic compounds (VOCs), we aimed to verify to which extent exhaled VOCs can characterize newly diagnosed COPD patients and changes in response to inhaled therapy. MATERIALS AND METHODS: Fifty newly diagnosed COPD patients were consecutively recruited among those attending the pulmonary medicine outpatient clinic at 'Campus Bio-Medico' University Hospital...
June 8, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29813036/central-and-peripheral-airway-nitric-oxide-in-patients-with-stable-and-exacerbated-chronic-obstructive-pulmonary-disease
#14
Zsófia Lázár, Ágnes Kelemen, Gabriella Gálffy, György Losonczy, Ildikó Horváth, András Bikov
Nitrative stress pathways are involved in airway inflammation characterizing chronic obstructive pulmonary disease (COPD). Extended nitric oxide (NO) analysis allows the partitioned measurement of nitrative stress in the conducting bronchi and peripheral airways/alveolar spaces. However, pulmonary NO production at these two sites has not been systemically studied in stable and exacerbated COPD. Twenty-eight patients with stable COPD, 34 patients during an exacerbation, and 15 smoking controls were recruited...
May 29, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29724959/new-breath-related-topics-sample-collection-for-exhaled-breath-condensate-and-aerosol-development-of-real-time-medical-alerts-measurement-of-artificial-atmospheres-and-analysis-of-legalized-cannabis-product
#15
Joachim D Pleil, M Ariel Geer Wallace
Exhaled breath technology is expanding beyond conventional gas-phase analysis, and conversely, methodology from other disciplines is finding applications in breath research. Recently, the authors attended conferences that incorporated new technologies into 'breath related' applications. The first was the International Submarine Air Monitoring and Air Purification (SAMAP) held in Uncasville Connecticut, November 2017, and the second was the Pittcon Conference and Exposition (Pittcon) held in Orlando, Florida, February 2018...
May 29, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29674598/online-monitoring-of-carbon-dioxide-and-oxygen-in-exhaled-mouse-breath-via-substrate-integrated-hollow-waveguide-fourier-transform-infrared-luminescence-spectroscopy
#16
Felicia Seichter, Erhan Tütüncü, Leila Tamina Hagemann, Josef Vogt, Ulrich Wachter, Michael Gröger, Sandra Kress, Peter Radermacher, Boris Mizaikoff
Exhaled breath offers monitoring bio markers, as well as diagnosing diseases and therapeutic interventions. In addition, vital functions may be non-invasively monitored online. Animal models are frequently used in research for determining novel therapeutic approaches and/or for investigating biological pathways. The exhaled carbon dioxide concentration, exhaled and inhaled oxygen concentration, and the subsequent respiratory quotient (RQ) offer insight into metabolic activity. One may adapt breath sampling systems and equipment designed for human applications to large animal studies...
May 29, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29560929/isotope-specific-breath-analysis-to-track-the-end-stage-renal-disease-during-hemodialysis
#17
Santanu Mandal, Prabuddha Mukhopadhyay, Chiranjit Ghosh, Mithun Pal, Gourab D Banik, Tanmoy Chatterjee, Shibendu Ghosh, Manik Pradhan
The underlying mechanisms towards the progression of end-stage renal disease (ESRD) in chronic kidney disease (CKD) are poorly understood and it still remains a major clinical stumbling block for early detection of CKD. Most patients with CKD pass through ESRD with the necessity of frequent hemodialysis (HD) treatment. At present, plasma urea and creatinine levels are examined in most CKD patients to monitor their health status after dialysis. But it is impossible to get immediate feedback on the patients' health as the conventional tests involve the collection of blood samples, laboratory processing for a prolonged period of time and, finally, analysis of those samples...
May 29, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29651988/evaluation-of-a-new-method-for-the-collection-and-measurement-of-8-isoprostane-in-exhaled-breath-for-future-application-in-nanoparticle-exposure-biomonitoring
#18
Caroline Marie-Desvergne, Muriel Dubosson, Véronique Chamel Mossuz
BACKGROUND: In the field of nanoparticle exposure biomonitoring, oxidative stress biomarkers measured in exhaled breath condensate appear promising to detect early respiratory effects in workers handling nanomaterials. However, condensation is known for its poor efficiency in collecting non-volatiles in exhaled breath, leading to the low sensitivity of such measurements. Moreover, to be easily used in field studies on large groups of workers, the collection device must be disposable and convenient...
May 14, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29648550/continuous-real-time-breath-analysis-in-ruminants-effect-of-eructation-on-exhaled-voc-profiles
#19
Peter Oertel, Anne Küntzel, Petra Reinhold, Heike Köhler, Jochen K Schubert, Johann Kolb, Wolfram Miekisch
BACKGROUND: The analysis of volatile organic compounds (VOCs) in breath allows non-invasive investigations of diseases. Animal studies are conducted as a model to perform research of VOCs and their relation to diseases. In large animal models ruminants were often used as experimental targets. The effect of their physiological eructation on VOC exhalation has not been examined yet and is the objective of this study. METHODS: Continuous breath profiles of two young cattle, four adult goats and four adult sheep were measured through a mask, covering mouth and nose, in real-time (200 ms) by means of proton transfer reaction time of flight mass spectrometry...
May 14, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29643267/measurement-of-breath-acetone-in-patients-referred-for-an-oral-glucose-tolerance-test
#20
B T E Andrews, W Denzer, G Hancock, A D Lunn, R Peverall, G A D Ritchie, K Williams
Breath acetone concentrations were measured in 141 subjects (aged 19-91 years, mean = 59.11 years, standard deviation = 12.99 years), male and female, undergoing an oral glucose tolerance test (OGTT), having been referred to clinic on suspicion of type 2 diabetes. Breath samples were measured using an ion-molecule-reaction mass spectrometer, at the commencement of the OGTT, and after 1 and 2 h. Subjects were asked to observe the normal routine before and during the OGTT, which includes an overnight fast and ingestion of 75 g glucose at the beginning of the routine...
May 14, 2018: Journal of Breath Research
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