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Journal of Breath Research

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https://www.readbyqxmd.com/read/29321341/exercise-tolerance-and-balance-of-inspiratory-to-expiratory-muscle-strength-in-relation-to-breathing-timing-in-patients-with-chronic-obstructive-pulmonary-disease
#1
Keisuke Miki, Kazuyuki Tsujino, Tatsuya Edahiro, Seigo Kitada, Mari Miki, Kenji Yoshimura, Hiroyuki Kagawa, Yohei Oshitani, Yuko Ohara, Yuki Hosono, Hiroyuki Kurebe, Ryoji Maekura
Little is known about the applicability of respiratory muscle training based on exertional pathophysiological conditions in patients with chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate the relationship between breathing timing and exertional responses, as well as whether exertional changes in the inspiratory duty cycle (inspiratory time [Ti]/total time [Ttot]) affect pathophysiological conditions, including respiratory muscles. Methods: Forty-five stable COPD patients (mean age: 71...
January 11, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29317573/ultrasensitive-sensor-based-on-nano-cu-polyaniline-nickel-foam-for-monitoring-h-sub-2-sub-o-sub-2-sub-in-exhaled-breath
#2
Aifeng Liu, Jing Liang, Rongguang Shi, Zongshan Zhao, Yong Tian
A sensitive, rapid and easy operated sensor for hydrogen peroxide (H2O2) determination in exhaled breath was developed in this study. The polyaniline (PANI) film and Cu nanoparticles were successively electrochemical deposited on the surface of the three-dimensional nickel foam, i.e., synthetized nano-Cu/polyaniline/nickel foam. The Ni foam facilitates the charge and mass transfer, and it also provides a large amount of anchoring sites for Cu nanoparticle deposition. The synergistic electro-catalytic actions between Cu nanoparticles and PANI highly enhanced the reduction current of H2O2...
January 10, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29295966/analysis-of-volatile-organic-compounds-in-the-breath-of-patients-with-stable-or-acute-exacerbation-of-chronic-obstructive-pulmonary-disease
#3
Alex Pizzini, Wojciech Filipiak, Johannes Wille, Clemens Ager, Helmut Wiesenhofer, Robert Kubinec, Jaroslav Blasko, Christoph Tschurtschenthaler, Christopher A Mayhew, Günter Weiss, Rosa Bellmann-Weiler
Chronic obstructive pulmonary disease (COPD) is a major cause of death worldwide. Acute exacerbations (AECOPD), caused by infectious and non-infectious agents, contribute to an increase in mortality. The diagnostic procedure of AECOPD is mainly based on clinical features. The aim of this pilot study was to identify whether volatile organic compounds (VOCs) in breath could be used to discriminate for acute exacerbated COPD. Three patient groups were included in this controlled study: AECOPD patients (n= 14, age mean ± SD: 71...
January 3, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29292699/instrumental-drift-removal-in-gc-ms-data-for-breath-analysis-the-short-term-and-long-term-temporal-validation-of-putative-biomarkers-for-copd
#4
Raquel Rodríguez-Pérez, Roldán Cortés, Ana Verónica Guamán, Antonio Pardo, Yolanda Torralba, Federico Gómez, Josep Roca, Joan Albert Barberà, Marta Cascante, Santiago Marco
Breath analysis holds the promise of a non-invasive technique for the diagnosis of diverse respiratory conditions including COPD and lung cancer. Breath contains small metabolites that may be putative biomarkers of these conditions. However, the discovery of reliable biomarkers is a considerable challenge in the presence of both clinical and instrumental confounding factors. Among the latter, instrumental time drifts are highly relevant, as since question the short and long-term validity of predictive models...
January 2, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29292698/the-potential-role-of-exhaled-breath-analysis-in-the-diagnostic-process-of-pneumonia-a-systematic-review
#5
Pouline van Oort, Pedro Povoa, Ronny Schnabel, Paul Dark, Antonio Artigas, Dennis Bergmans, Timothy Felton, Luis Coelho, Marcus J Schultz, Stephen J Fowler, Lieuwe Bos
Diagnostic strategies currently used for pneumonia are time-consuming, lack accuracy and suffer from large inter-observer variability. Exhaled breath contains thousands of volatile organic compounds (VOCs), which include products of host and pathogen metabolism. In this systematic review we investigated the use of so-called 'breathomics' for diagnosing pneumonia. A Medline search yielded 18 manuscripts reporting on animal and human studies using organic and inorganic molecules in exhaled breath, that all could be used to answer whether analysis of VOC profiles could potentially improve the diagnostic process of pneumonia...
January 2, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29269592/tongue-coating-its-characteristics-and-role-in-intra-oral-halitosis-and-general-health-a-review
#6
Kavitha Seerangaiyan, Frits Juch, Edwin G Winkel
Tongue coating (TC), a grayish white deposit on the tongue, is the main cause of intra-oral halitosis (IOH), a major socially unacceptable issue. This review covers the general features of TC, including its formation and the factors that influence it. Indeed, volatile sulfur compounds (VSC) are the principal elements of IOH, and TC and periodontal diseases are the two main sources of VSC. This review covers the relationship between VSC, TC, and periodontal disease. Moreover, we will comprehensively discuss the methods that are employed to quantify TC, its microbial composition, the influence on general health and the importance in general medicine...
December 22, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29244031/transition-and-post-transition-metals-in-exhaled-breath-condensate
#7
Andrew Ghio, Michael C Madden, Charles R Esther
Water vapor in expired air, as well as dispersed non-volatile components, condense onto a cooler surface after exiting the respiratory tract. This exhaled breath condensate (EBC) provides a dilute sampling of the epithelial lining fluid. Accordingly, the collection of EBC imparts a capacity to provide biomarkers of injury preceding clinical disease. Concentrations of transition and post-transition metals in EBC are included among these endpoints. Iron and zinc are those metals in highest concentration and are measurable in all EBC samples from healthy subjects; other metals are most frequently either at or below the level of detection in this group...
December 15, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29231842/smell-of-cells-volatile-profiling-of-stem-and-non-stem-cell-proliferation
#8
Ann-Christin Bischoff, Peter Oertel, Pritam Sukul, Christian Rimmbach, Robert David, Jochen Schubert, Wolfram Miekisch
Bacterial and cell cultures are known to emit a large number of volatile organic compounds (VOCs). Conventional biochemical methods are often destructive, time-consuming and ex-pensive. In contrast, VOC analysis of headspace over cultures, may offer a non-destructive alternative to monitor cell proliferation and metabolism. VOC profiles from cultures of murine pluripotent stem cells and fibroblasts were assessed every 24 hours for 3 days. Pure cell media were measured as parallel controls. VOC analysis was highly standardized with respect to time of measurement and phases of cell growth...
December 12, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29219122/towards-the-use-of-breath-for-detecting-mycobacterial-infection-a-case-study-in-a-murine-model
#9
Flavio Antonio Franchina, Theodore Robert Mellors, Minara Aliyeva, Jeffrey Wagner, Nirav Daphtary, Lennart Lundblad, Sarah M Fortune, Eric J Rubin, Jane E Hill
In the present research, the potential of breath analysis by comprehensive two-dimensional gas chromatography coupled to mass spectrometry (GC×GC-MS) was investigated for the discrimination between healthy and infected mice. A pilot study employing a total of 16 animals was used to develop a method for breath analysis in a murine model for studying MTBC (Mycobacterium tuberculosis complex) using the M. bovis BCG (Bacillus Calmette-Guérin). Breath was collected in Tedlar bags and concentrated onto thermal desorption tubes for the subsequent analysis by GC×GC-MS...
December 8, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29199640/effects-of-humidity-co-sub-2-sub-and-o-sub-2-sub-on-real-time-quantitation-of-breath-biomarkers-by-means-of-ptr-tof-ms
#10
Phillip Trefz, Jochen Schubert, Wolfram Miekisch
Proton-transfer-reaction-time-of-flight-mass-spectrometry (PTR-ToF-MS) represents an attractive tool for real-time analysis of VOC profiles in human breath. Quantification of breath VOCs by means of direct MS may be affected by the matrix as human breath does not only contains several hundred VOCs in the ppbV-pptV level but is water saturated and contains percentage levels of CO2. Investigation of breath biomarkers in clinical studies requires quantitative and comparable results. We, therefore, assesed systematically the effect of humidity, CO2 and O2 onto the results of PTR-MS analysis...
December 4, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29199639/ovarian-cycle-may-influence-the-exhaled-volatile-organic-compounds-profile-analyzed-by-an-electronic-nose
#11
Silvano Dragonieri, Vitaliano Nicola Quaranta, Pierluigi Carratu, Teresa Ranieri, Onofrio Resta
We aimed to investigate whether sexual hormonal profile during ovarian cycle could affect the Volatile Organic Compound (VOC)-profile analyzed by an electronic nose (e-nose) in healthy women. METHODS. We enrolled 21 healthy, never-smoking, regularly menstruating females, who were not taking any medications. A series of exhaled breath measurements were performed on all subjects at predefined intervals (days 1-6, 7-12, 13-19, 20-25, and 26-31; day 1 was the 1st day of menstruation) during their ovarian cycle and analyzed by an e-nose (Cyranose 320)...
December 4, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29199638/volatile-fingerprinting-of-human-respiratory-viruses-from-cell-culture
#12
Giorgia Purcaro, Christiaan Rees, Wendy Wieland-Alter, Mark J Schneider, Xi Wang, Pierre-Hugues Stefanuto, Peter F Wright, Richard I Enelow, Jane E Hill
Volatile metabolites are currently under investigation as potential biomarkers for the detection and identification of pathogenic microorganisms, including bacteria, fungi, and viruses. Unlike bacteria and fungi, which produce distinct volatile metabolic signatures associated with innate differences in both primary and secondary metabolic processes, viruses are wholly reliant on the metabolic machinery of infected cells for replication and propagation. In the present study, the ability of volatile metabolites to discriminate between respiratory cells infected and uninfected with virus, in vitro, was investigated...
December 4, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29189203/proteomic-characterization-of-human-exhaled-breath-condensate
#13
Maud Lacombe, Caroline Marie-Desvergne, Florence Combes, Alexandra Kraut, Christophe Bruley, Yves Vandenbrouck, Véronique Chamel Mossuz, Yohann Couté, Virginie Brun
To improve biomedical knowledge and to support biomarker discovery studies, it is essential to establish comprehensive proteome maps for human tissues and biofluids, and to make them publicly accessible. In this study, we performed an in-depth proteomics characterization of exhaled breath condensate (EBC), a sample obtained non-invasively by condensation of exhaled air that contains submicron droplets of airway lining fluid. Two pooled samples of EBC, each obtained from 10 healthy donors, were processed using a straightforward protocol based on sample lyophilization, in-gel digestion and liquid chromatography tandem-mass spectrometry (LC-MS/MS) analysis...
November 30, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29182524/long-term-proton-pump-inhibitor-therapy-leads-to-small-bowel-bacterial-overgrowth-as-determined-by-breath-hydrogen-and-methane-excretion
#14
Agnieszka Sieczkowska, Piotr Landowski, Artur Gibas, Barbara Kaminska, Carlos Lifschitz
Prolonged suppression of gastric acid secretion by proton pump inhibitors (PPIs) may alter the bacterial microbiota of the upper gastrointestinal tract and lead to small bowel bacterial overgrowth (SBBO). Published reports have shown conflicting results on the association between PPI therapy and risk of SBBO development. We evaluated whether long-term PPI treatment is associated with presence of SBBO as determined by breath hydrogen (H2) and methane (CH4) excretion. We also assessed the differences in H2 / CH4 excretion patterns in patients taking PPI compared with those not taking the medication and searched for the potential predictors of a positive breath test result...
November 28, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29176061/exhaled-breath-temperature-in-optimally-treated-asthmatics-severity-and-underlying-mechanisms
#15
Polyxeni Ntontsi, Petros Bakakos, Evgenia Papathanasiou, Zoi Tsilogianni, Konstantinos Kostikas, Georgios Hillas, Georgios Papatheodorou, Nikolaos G Koulouris, Spyridon Papiris, Stelios Loukides
ABSTRACT Introduction: Increased vascularity may lead to loss of heat in the airways and may modulate Exhaled breath temperature (EBT). Increased EBT has been associated with uncontrolled asthma. Aim: We wanted to determine whether the measurement of EBT in optimally treated asthmatic patients is influenced by the increased vascular permeability and whether Vascular endothelial growth factor (VEGF) is implicated in the above process. Furthermore, to assess the impact of asthma severity on EBT values...
November 27, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29167414/biomarkers-related-to-respiratory-symptoms-and-lung-function-in-adults-with-asthma
#16
Lucia Calciano, Laura Portas, Angelo Guido Corsico, Mario Olivieri, Paolo Degan, Marcello Ferrari, Alessandro Fois, Anna Maria Fratta Pasini, Andrea Pasini, Maria Elisabetta Zanolin, Roberto de Marco, Simone Accordini
There is a need for easily measurable biomarkers that are able to identify different levels of asthma severity. Aim. To assess the association between peripheral blood cell counts, fractional nitric oxide in exhaled air (FeNO), urinary biomarkers of oxidative stress (8-hydroxy-2'-deoxyguanosine and 8-isoprostane), and asthma severity in adult patients from the general population. Methods. In the Gene Environment Interactions in Respiratory Diseases study, 287 subjects with asthma (aged 20-64) were identified from the general population in Verona (Italy) (2008-2010)...
November 23, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29146889/exhaled-markers-of-anti-oxidant-activity-and-oxidative-stress-in-stable-cystic-fibrosis-patients-with-moderate-lung-disease
#17
Lucia Spicuzza, Giuseppe Fabio Parisi, Lucia Tardino, Nicola Ciancio, Raffaella Nenna, Fabio Midulla, Salvatore Leonardi
The sustained imbalance between oxidant and antioxidant species contributes to lung damage in patients with cystic fibrosis (CF). Glutathione (GSH) is an important component of the antioxidant defense in the airways epithelial lining fluid and its transportation out of the cells may be altered in CF. The aim of this study was to assess the oxidants/anti-oxidants balance in the airways of patients with CF. We measured the concentrations of GSH, the total antioxidant capacity and the concentration of 8-iso-prostaglandin F2α (8-isoprostane), a marker of oxidative stress, in the exhaled breath condensate of 17 non-smoking patients with CF, in stable phase, and in 17 age-matched healthy subjects...
November 17, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29146888/halitosis-in-children-with-adenoid-hypertrophy
#18
Małgorzata Sikorska-Żuk, Marek Bochnia
This paper attempts to identify the sources and evaluate the prevalence of halitosis in children with adenoid hypertrophy. The study included pediatric patients admitted for adenoidectomy due to obstructive symptoms. Patients with possibly other causes of halitosis, were excluded from the study. Halitosis was detected in 30 out of 136 children (22.1%). The effect of adenoid hypertrophy on halitosis was confirmed by the significant reduction in the organoleptic score rated according to the Rosenberg Scale (on average by 2 degrees) and the levels of volatile sulfur compounds (VSCs) (on average 84 ppb) post-adenoidectomy, as compared to pre-surgery results...
November 17, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29109305/breath-based-diagnosis-of-fungal-infections
#19
Mahesh Jayamanna Thalavitiya Acharige, Seena Koshy, Nour Ismail, Obadah Aloum, Majd Jazaerly, Carmen Leon Astudillo, Sophia Koo
Invasive aspergillosis and other invasive fungal infections are associated with significant morbidity and mortality in immunocompromised patients, in large part due to limitations of existing diagnostic methods for these infections. Detection of species-specific volatile sesquiterpene metabolites of fungal origin in the breath of patients with invasive fungal infections allows the diagnosis and monitoring of these infections in vivo, noninvasively and more rapidly than possible with current diagnostic methods...
November 7, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29104183/exhaled-breath-aerosol-eba-the-simplest-non-invasive-medium-for-public-health-and-occupational-exposure-biomonitoring
#20
Joachim D Pleil, Ariel Wallace, Michael C Madden
Exhaled breath collection has long been recognized as requiring the least invasive methods of the biological fluids and so is preferred for environmental and public health studies. This commentary describes how breath biomonitoring is generally preferred for certain logistical reasons in public health and occupational biomonitoring. Three different fractions of exhaled breath are considered: gas-phase, liquid condensate, and aerosols. The focus is on the exhaled breath aerosol (EBA) fraction and the development of targeted sampling and analysis methods...
November 6, 2017: Journal of Breath Research
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