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BMC Research Notes

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https://www.readbyqxmd.com/read/28302157/reliability-of-medical-records-in-diagnosing-inflammatory-breast-cancer-in-egypt
#1
Lynne Le, Catherine Schairer, Ahmed Hablas, Jane Meza, Shinobu Watanabe-Galloway, Mohamed Ramadan, Sofia D Merajver, Ibrahim A Seifeldin, Amr S Soliman
BACKGROUND: Inflammatory breast cancer (IBC) is a rare, aggressive breast cancer diagnosed clinically by the presence of diffuse erythema, peau d'orange, and edema that arise quickly in the affected breast. This study evaluated the validity of medical records in Gharbiah, Egypt in identifying clinical signs/symptoms of IBC. For 34 IBC cases enrolled in a case-control study at the Gharbiah Cancer Society and Tanta Cancer Center, Egypt (2009-2010), we compared signs/symptoms of IBC noted in medical records to those recorded on a standardized form at the time of IBC diagnosis by clinicians participating in the case-control study...
March 16, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28298240/interstrain-differences-in-the-expression-and-activity-of-cyp2a5-in-the-mouse-liver
#2
Katia S Poça, Thiago E M Parente, Lucas F Chagas, Bruna S Leal, Hellen S Leal, Francisco J R Paumgartten, Ana C A X De-Oliveira
BACKGROUND: Cytochrome P450 2A5 (Cyp2a5), a mouse enzyme orthologous of human CYP2A6, catalyzes a number of toxicologically important reactions, including the metabolism of nicotine, aflatoxin B1, and several other xeno- and endobiotics. Cyp2a5 expression is complex and not yet fully understood. We investigated inter-strain differences in the activity and mRNA expression of hepatic Cyp2a5. Cyp1a1/2 and Cyp2b9/10 activities were evaluated for comparative purposes. Data on the interstrain differences in the expression and activity of Cyp2a5 are important to select a suitable mouse model for studying CYP2A6-mediated metabolism...
March 15, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28292330/microrna-expression-profiles-in-human-cd3-t-cells-following-stimulation-with-anti-human-cd3-antibodies
#3
Isabel Garcia Sousa, Manuela Maragno do Almo, Kelly Cristina Rodrigues Simi, Maryani Andressa Gomes Bezerra, Rosângela Vieira Andrade, Andréa Queiroz Maranhão, Marcelo Macedo Brigido
BACKGROUND: Anti-CD3 therapy can induce immunosuppression by several non mutually exclusive mechanisms that have been proposed to explain the therapeutic effect the administration anti-CD3 mAb, but its immunoregulatory mechanism is still not completely clear. In T cells, microRNAs (miRNAs) regulate several pathways, including those associated with immune tolerance. Here, we report changes in miRNA expression in T cells following treatment with anti-human CD3 antibodies. Peripheral blood mononuclear cells were cultured in the presence of the monoclonal antibody OKT3 or a recombinant fragment of humanized anti-CD3...
March 14, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28288691/immunological-diagnosis-as-an-adjunctive-tool-for-an-early-diagnosis-of-tuberculous-meningitis-of-an-immune-competent-child-in-a-low-tuberculosis-endemic-country-a-case-report
#4
Serena Vita, Camilla Ajassa, Emanuela Caraffa, Miriam Lichtner, Claudia Mascia, Fabio Mengoni, Maria Grazia Paglia, Cristina Mancarella, Davide Colistra, Claudio Di Biasi, Rosa Maria Ciardi, Claudio Maria Mastroianni, Vincenzo Vullo
BACKGROUND: Pediatric tuberculous meningitis is a highly morbid, often fatal disease. Its prompt diagnosis and treatment saves lives, in fact delays in the initiation of therapy have been associated with high mortality rates. CASE PRESENTATION: This is a case of an Italian child who was diagnosed with tuberculous meningitis after a history of a month of headache, fatigue and weight loss. Cerebrospinal fluid analysis revealed a lymphocytic pleocytosis with predominance and decreased glucose concentration...
March 13, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28274266/rna-isolation-from-precision-cut-lung-slices-pcls-from-different-species
#5
Monika Niehof, Tobias Hildebrandt, Olga Danov, Kirsten Arndt, Jeannette Koschmann, Franziska Dahlmann, Tanja Hansen, Katherina Sewald
BACKGROUND: Functional 3D organ models such as precision-cut lung slices (PCLS) have recently captured the attention of biomedical research. To enable wider implementation in research and development, these new biologically relevant organ models are being constantly refined. A very important issue is to improve the preparation of high-quality RNA (ribonucleic acid) from PCLS for drug discovery and development of new therapies. Gene expression analysis at different levels is used as an important experimental readout...
March 9, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28274251/knowledge-and-factors-associated-with-pain-management-for-hospitalized-children-among-nurses-working-in-public-hospitals-in-mekelle-city-north-ethiopia-cross-sectional-study
#6
Remla Miftah, Weyzer Tilahun, Atsde Fantahun, Seid Adulkadir, Kahsu Gebrekirstos
BACKGROUND: American Nurses Association reflects, the role of the nurse in pain management encompasses the entire nursing process, assessment of pain, plans pharmacological and non-pharmacological pain management strategies, implements the plan, and evaluates the response of the patient to the interventions. Pediatric pain management has been left largely unaddressed due to factors like limited resources, inadequate training, as well as cultural diversity and language barriers which made sick and injured children not to receive basic pain care...
March 9, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28270186/total-cardiovascular-risk-for-next-10%C3%A2-years-among-rural-population-of-nepal-using-who-ish-risk-prediction-chart
#7
Mahesh Kumar Khanal, M S A Mansur Ahmed, Mohammad Moniruzzaman, Palash Chandra Banik, Raja Ram Dhungana, Pratiksha Bhandari, Surya Devkota, Arun Shayami
BACKGROUND: Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality globally. Primary prevention of CVD based on total CVD risk approach using WHO/ISH risk prediction chart would be more effective to stratify population under different risk levels, prioritize and utilize the scarce resources of low and middle-income countries. This study estimated total 10-year CVD risk and determined the proportion of population who need immediate drug therapy among the rural population of Nepal...
March 7, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28264708/effectiveness-of-persea-major-kopp-lauraceae-extract-against-enterococcus-faecalis-a-preliminary-in-vitro-study
#8
Lusiane Volpato, Marilisa Carneiro Leão Gabardo, Denise Piotto Leonardi, Paulo Henrique Tomazinho, Leila Teresinha Maranho, Flares Baratto-Filho
BACKGROUND: Persea major Kopp (Lauraceae) is a plant with wound healing, antibacterial, and analgesic properties. The aim of this study was to assess the in vitro antibacterial activity of the concentrated crude extract (CCE) and ethyl acetate fraction (EAF) of this plant against Enterococcus faecalis and compare it with calcium hydroxide [Ca(OH)2] paste and 2% chlorhexidine digluconate (CHX). METHODS: The plant material was collected, and an extract was prepared according to the requirements of the study (CCE and EAF)...
March 6, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28264703/life-threatening-emphysematous-liver-abscess-associated-with-poorly-controlled-diabetes-mellitus-a-case-report
#9
Yuichi Takano, Masafumi Hayashi, Fumitaka Niiya, Toru Nakanishi, Shotaro Hanamura, Kunio Asonuma, Eiichi Yamamura, Kuniyo Gomi, Yuichiro Kuroki, Naotaka Maruoka, Kazuaki Inoue, Masatsugu Nagahama
BACKGROUND: Emphysematous liver abscesses are defined as liver abscesses accompanied by gas formation. The fatality rate is extremely high at 27%, necessitating prompt intensive care. CASE PRESENTATION: The patient was a 69-year-old Japanese man with type 2 diabetes. He visited the emergency outpatient department for fever and general malaise that had been ongoing for 2 weeks. Abdominal computed tomography revealed an abscess 5 cm in diameter accompanied by gas formation in the right hepatic lobe...
March 6, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28264698/cytotoxicity-antimicrobial-and-antioxidant-activity-of-eight-compounds-isolated-from-entada-abyssinica-fabaceae
#10
Jean P Dzoyem, Raduis Melong, Armelle T Tsamo, Alembert T Tchinda, Deccaux G W F Kapche, Bonaventure T Ngadjui, Lyndy J McGaw, Jacobus N Eloff
BACKGROUND: Entada abyssinica is a plant traditionally used against gastrointestinal bacterial infections. Eight compounds including three flavonoids, three terpenoids, a monoglyceride and a phenolic compound isolated from E. abyssinica were investigated for their cytotoxicity, antibacterial and antioxidant activity. RESULTS: Compounds 7 and 2 had remarkable activity against Salmonella typhimurium with the lowest respective minimum inhibitory concentration (MIC) values of 1...
March 6, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28259182/an-unexpected-diagnosis-of-human-immunodeficiency-virus-2-infection-in-an-overseas-visitor-a-case-report
#11
Asma Sohail, Lyndal Van Leer, Natasha Holmes
BACKGROUND: Human immunodeficiency virus 2 infection is endemic in West Africa but is also found in parts of Europe, North and South America, and India where it is thought to have been introduced secondary to migration and commercial trade ties. It is less common than Human immunodeficiency virus 1, with differences in pathogenicity, lower rates of transmission, longer asymptomatic period and slower progression to acquired immunodeficiency syndrome. Human immunodeficiency virus 2 is also associated with diagnostic challenges given the lack of commercially available diagnostic tests, and management challenges given intrinsic resistance to many anti-retroviral therapies...
March 4, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28253905/perceived-stress-and-quality-of-life-of-pharmacy-students-in-university-of-ghana
#12
Adomah Opoku-Acheampong, Irene A Kretchy, Franklin Acheampong, Barima A Afrane, Sharon Ashong, Bernice Tamakloe, Alexander K Nyarko
BACKGROUND: Stress among pharmacy students could greatly affect their learning activities and general well-being. It is therefore necessary to investigate how stress relates with the quality of life of students to maintain and/or improve their personal satisfaction and academic performance. A school-based longitudinal study was used to investigate the relationship between stress and quality of life of undergraduate pharmacy students. The 10-item perceived stress scale and the shorter version of the WHO quality of life scale were administered to the same participants at two time points i...
March 2, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28249618/locally-advanced-colon-cancer-with-cutaneous-invasion-case-report
#13
Nádia Tenreiro, Cátia Ferreira, Silvia Silva, Rita Marques, Artur Ribeiro, Paulo Jorge Sousa, Fernando Próspero Luís
BACKGROUND: Locally advanced colon cancer with direct abdominal wall and skin invasion is an extremely rare finding with most data being derived from case reports, historical autopsy-based or single-center retrospective studies. We present a unique case of a colon cancer with direct cutaneous invasion and colocutaneous fistulization. CASE PRESENTATION: Eighty-six year old Caucasian female with multiple comorbidities, referred to Surgical Consultation due to ulcerated skin lesion in the abdomen...
March 1, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28249589/diagnostic-and-therapeutic-challenges-of-an-ambiguous-cystic-kidney-disease-in-a-resource-limited-setting-a-case-report
#14
Christian Akem Dimala, Ndemazie Nkafu Bechem, Benjamin Momo Kadia, Vitalis Fambombi Feteh, Simeon Pierre Choukem
BACKGROUND: Unilateral renal cystic disease is a rare condition that shares morphological similarities with multicystic dysplastic kidney, the former often distinguished from the latter on some clinical and histopathological grounds. However serious diagnostic and therapeutic dilemmas set in when there is a considerable overlap in the distinguishing features between these entities. CASE PRESENTATION: A 19-year-old African female presented with a chronic severe debilitating right lower quadrant abdominal pain refractory to analgesics...
March 1, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28241884/radiotherapy-of-nasopharyngeal-cancer-using-rapidarc-dosimetric-study-of-military-teaching-hospital-mohamed-v-morocco
#15
Issam Lalya, El Amin Marnouche, Maghous Abdelhak, Noha Zaghba, Khalid Andaloussi, Mohamed Elmarjany, Laila Baddouh, Keltoum Dahmani, Khalid Hadadi, Hassan Sifat, Hamid Mansouri
BACKGROUND: The aim of the present study is to assess efficacy and efficiency of Volumetric-modulated arc therapy (VMAT) technique in treatment of nasopharyngeal cancer in our institution and to report toxicity related to this technique. METHODS: Between June 2013 and January 2015, thirty-two patients with non metastatic nasopharyngeal cancer were curatively treated using VMAT Rapidarc. Dose prescription was performed using two different schedules, it consisted of either simultaneous integrated boost or simultaneous modulated accelerated radiation therapy delivering 70 Gy in 35 fractions and 69...
February 28, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28241865/utilization-of-outreach-immunization-services-among-children-in-hoima-district-uganda-a-cluster-survey
#16
MULTICENTER STUDY
Paul Oryema, Juliet N Babirye, Charles Baguma, Peter Wasswa, David Guwatudde
BACKGROUND: The global vaccine action plan 2011-2020 was endorsed by 194 states to equitably extend the benefits of immunization to all people. However, gaps in vaccination coverage remain in developing countries such as Uganda. One of the strategies used to tackle existing inequities is implementation of outreach immunization services to deliver services to those with poor geographical access. However, reports of inconsistent use of these services prevail; therefore understanding the factors associated with use of these services is critical for improving service delivery...
February 27, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28241857/haemophagocytic-syndrome-in-an-adult-suffering-from-pyrexia-of-unknown-origin-an-uncommon-presentation-of-tuberculosis-a-case-report
#17
Wasim Md Mohosin Ul Haque, Md Erfanur Rahman Shuvo, Muhammad Abdur Rahim, Palash Mitra, Tabassum Samad, Jalaluddin Ashraful Haque
BACKGROUND: Tuberculosis is common, can involve various organs of the body and may have diverse presentations. Haemophagocytic syndrome is one of the rare presentations of tuberculosis carrying a very high mortality. Early detection and institution of anti-tuberculosis medications can be life-saving. CASE PRESENTATION: A 23-year-old Bengali man presented with prolonged fever, weight loss, hepatosplenomegaly, pancytopenia and altered liver function. He had high erythrocyte sedimentation rate, positive tuberculin test, granuloma in liver biopsy, and haemophagocytosis was evidenced by histopathological examination of bone marrow...
February 27, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28235422/crying-spells-triggered-by-thumb-index-rubbing-after-thalamic-stroke-a-case-report
#18
R Bassani, C Rosazza, L Ghirardin, V Caldiera, E Banco, C Casati, L Tesio
BACKGROUND: Pathologic crying, devoid of any emotional counterpart, is known to occur as a consequence of various brain stem, cortical hemispheric and cerebellar lesions or, quite exceptionally, of "dacrystic" epilepsy. The case reported here suggests that thalamic lesions may also cause crying spells, under the special circumstances described below. CASE PRESENTATION: After a mild left thalamic stroke a caucasian 77 years old man presented with crying spells with no emotional counterpart, triggered by thumb-index rubbing of his right hand...
February 24, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28235420/altered-expression-profiles-of-microrna-families-during-de-etiolation-of-maize-and-rice-leaves
#19
Jiajia Xu, Yuanyuan Li, Yaling Wang, Xinyu Liu, Xin-Guang Zhu
BACKGROUND: MicroRNAs (miRNAs) are highly conserved small non-coding RNAs that play important regulatory roles in plants. Although many miRNA families are sequentially and functionally conserved across plant kingdoms (Dezulian et al. in Genome Biol 13, 2005), they still differ in many aspects such as family size, average length, genomic loci etc. (Unver et al. in Int J Plant Genomics, 2009). RESULTS: In this study, we investigated changes of miRNA expression profiles during greening process of etiolated seedlings of Oryza sativa (C3) and Zea mays (C4) to explore conserved and species-specific characteristics of miRNAs between these two species...
February 24, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28235417/accuracy-of-glomerular-filtration-rate-equations-for-chronic-kidney-disease-patients-at-the-g3a-stage-a-single-center-cross-sectional-study
#20
Yanna Dou, Xiran Sun, Dong Liu, Li Zhang, Jing Xiao, Genyang Cheng, Dahai Yu, Zhanzheng Zhao
BACKGROUND: Kidney disease improving global outcomes provided a new classification for chronic kidney disease (CKD) by subdividing the G3 stage into G3a and G3b stages based on glomerular filtration rate (GFR) in 2012. Currently, a few methods are used to evaluate GFR, including measured GFR (mGFR) and estimated GFR (eGFR). One of the mGFR was (99m)Tc-DTPA scintigraphy method and eGFR using GFR equations were used clinically. Equations were modification of diet in renal disease (MDRD), chronic kidney disease epidemiology collaboration (CKD-EPI), and Chinese adapted MDRD (C-MDRD)...
February 24, 2017: BMC Research Notes
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