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BMC Research Notes

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https://www.readbyqxmd.com/read/29149911/the-analysis-of-novel-microrna-mimic-sequences-in-cancer-cells-reveals-lack-of-specificity-in-stem-loop-rt-qpcr-based-microrna-detection
#1
Patrick Winata, Marissa Williams, Eileen McGowan, Najah Nassif, Nico van Zandwijk, Glen Reid
OBJECTIVE: MicroRNAs are frequently downregulated in cancer, and restoring expression has tumour suppressive activity in tumour cells. Our recent phase I clinical trial investigated microRNA-based therapy in patients with malignant pleural mesothelioma. Treatment with TargomiRs, microRNA mimics with novel sequence packaged in EGFR antibody-targeted bacterial minicells, revealed clear signs of clinical activity. In order to detect delivery of microRNA mimics to tumour cells in future clinical trials, we tested hydrolysis probe-based assays specific for the sequence of the novel mimics in transfected mesothelioma cell lines using RT-qPCR...
November 17, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29145883/self-reported-actual-and-desired-proportion-of-sitting-standing-walking-and-physically-demanding-tasks-of-office-employees-in-the-workplace-setting-do-they-fit-together
#2
Birgit Wallmann-Sperlich, Josephine Y Chau, Ingo Froboese
OBJECTIVE: Occupational sitting time in white-collar workers represents a prominent contributor to overall daily sitting time, which is associated with various health risks. Workplace interventions intending to reduce sitting time during work typically focus on replacing sitting with standing. The aim was to investigate and compare actual and desired proportions of time spent sitting, standing, walking, and doing physically demanding tasks at work reported by desk-based workers. Cross-sectional data were collected from German desk-based workers (n = 614; 53...
November 17, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29145881/multiple-small-hemorrhagic-infarcts-in-cerebral-air-embolism-a-case-report
#3
Masaya Togo, Taku Hoshi, Ryosuke Matsuoka, Yukihiro Imai, Nobuo Kohara
BACKGROUND: Cerebral air embolism is a rare cause of cerebral infarction. In cerebral air embolism, T2 star-weighted imaging shows numerous spotty hypointense signals. Previous reports have suggested that these signals represent air in the brain and are gradually diminished and absorbed. We experienced two cases of cerebral air embolism, and in one of them, we conducted an autopsy. CASE PRESENTATION: Case 1 was a 76-year-old Japanese man with lung cancer and emphysema...
November 16, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29145870/bacillus-anthracis-gamma-phage-lysis-among-soil-bacteria-an-update-on-test-specificity
#4
Cari B Kolton, Nicole L Podnecky, Sean V Shadomy, Jay E Gee, Alex R Hoffmaster
BACKGROUND: Bacillus anthracis, which causes anthrax in humans and animals, is enzootic in parts of the U.S. state of Texas where cases are typically reported in animals annually. The gamma phage lysis assay is a common diagnostic method for identification of B. anthracis and is based on the bacterium's susceptibility to lysis. This test has been shown to be 97% specific for B. anthracis, as a small number of strains of other Bacillus spp. are known to be susceptible. In this study, we evaluated the performance of a combination of B...
November 16, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29141693/glycemic-control-and-associated-factors-among-type-2-diabetic-patients-at-shanan-gibe-hospital-southwest-ethiopia
#5
Daniel Miteku Yigazu, Tigestu Alemu Desse
OBJECTIVE: The aim of this study was to assess the rate of glycemic control and factors affecting glycemic control in type 2 diabetic patients. RESULTS: A total of 174 type 2 diabetic patients were interviewed and were studied. Mean age of the patients was 48.98 ± 14.96 years (range 18-80 years). More than half (51.7%) of the patients were males. About a third of patients, 53 (30.5%), were on antidiabetic medications for less than 5 years. The most common prescribed antidiabetic medications were insulin, 48 (27...
November 15, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29137662/peer-assisted-learning-among-sri-lankan-medical-undergraduates-a-cross-sectional-study
#6
Nipun Lakshitha de Silva, Balasundaram Parththipan, Chaturaka Rodrigo, Godwin Constantine, Sumadhya Deepika Fernando, Senaka Rajapakse
OBJECTIVE: The objectives of this study were to; (a) evaluate the current practices of peer assisted learning among second year and final year medical students of Faculty of Medicine, University of Colombo, Sri Lanka; (b) identify reasons for engaging in peer assisted learning; (c) identify perceived weaknesses in current learning activities; and (d) determine student characteristics associated with engaging in peer assisted learning. RESULTS: This cross sectional study interviewed two hundred and eighty-four eligible students...
November 14, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29137656/how-brunei-trainee-teachers-cope-with-distress-counseling-implications
#7
Lawrence Mundia
OBJECTIVE: This study investigated the strategies used by student teachers when dealing with distress during training. Specifically, this study addressed the following research goals: (1) identify Ways of Coping that predict achievement on a quantitative reasoning test; (2) determine participants' coping differences per sex, age, and ability in quantitative reasoning; and (3) reveal coping strategies that work best for each and both sexes in fostering academic achievement in quantitative reasoning...
November 14, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29132439/the-proportion-of-the-population-of-england-that-self-identifies-as-lesbian-gay-or-bisexual-producing-modelled-estimates-based-on-national-social-surveys
#8
Sanne Christine van Kampen, William Lee, Mauro Fornasiero, Kerryn Husk
OBJECTIVES: There is currently no widely accepted estimate of the proportion of people in England that self-identifies as lesbian, gay or bisexual (LGB), which is needed if we are to compare health inequality between different population groups. Using systematic review methods, this study identified all national social surveys with a question on sexual orientation and pooled those which represented the overall population of England. LGB proportions were synthesized into an aggregated mean estimate using weights based on sample size, response rate and missing data...
November 13, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29132418/indoor-air-pollution-from-secondhand-tobacco-smoke-solid-fuels-and-kerosene-in-homes-with-active-tuberculosis-disease-in-south-africa
#9
Jessica L Elf, Onyinyechi Eke, Modiehi Rakgokong, Ebrahim Variava, Yudesh Baliram, Katlego Motlhaoleng, Limakatso Lebina, Adrienne E Shapiro, Patrick N Breysse, Jonathan E Golub, Neil Martinson
OBJECTIVES: Secondhand tobacco smoke (SHS), use of solid fuels, and kerosene may play an important role in perpetuating the tuberculosis (TB) epidemic. The purpose of this study was to explore the prevalence of household air pollution (HAP) from these sources in homes of someone with TB in a high HIV-prevalence setting. A convenience sample of homes and household members participating in an ongoing active case-finding study in Matlosana district townships surrounding Klerksdorp, South Africa were included...
November 13, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29132417/quantifying-mitochondrial-dna-copy-number-using-robust-regression-to-interpret-real-time-pcr-results
#10
Paulo Refinetti, David Warren, Stephan Morgenthaler, Per O Ekstrøm
BACKGROUND: Real time PCR (rtPCR) is a quantitative assay to determine the relative DNA copy number in a sample versus a reference. The [Formula: see text] method is the standard for the analysis of the output data generated by an rtPCR experiment. We developed an alternative based on fitting a robust regression to the rtPCR signal. This new data analysis tool reduces potential biases and does not require all of the compared DNA fragments to have the same PCR efficiency. RESULTS: Comparing the two methods when analysing 96 identical PCR preparations showed similar distributions of the estimated copy numbers...
November 13, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29132407/frequency-and-determinants-for-hemorrhagic-transformation-of-posterior-cerebral-stroke-posterior-ischemic-stroke-and-hemorrhagic-transformation
#11
Francesca Valentino, Luana Gentile, Valeria Terruso, Sergio Mastrilli, Paolo Aridon, Paolo Ragonese, Caterina Sarno, Giovanni Savettieri, Marco D'Amelio
BACKGROUND: hemorrhagic transformation is a threatening ischemic stroke complication. Frequency of hemorrhagic transformation differs greatly among studies, and its risk factors have been usually studied in patients with anterior ischemic stroke who received thrombolytic therapy. We evaluated, in a hospital-based series of patients with posterior ischemic stroke not treated with thrombolysis, frequency and risk factors of hemorrhagic transformation. Patients with posterior circulation stroke were seen in our Department during the period January 2004 to December 2009...
November 13, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29126456/virological-response-hiv-1-drug-resistance-mutations-and-genetic-diversity-among-patients-on-first-line-antiretroviral-therapy-in-n-djamena-chad-findings-from-a-cross-sectional-study
#12
Chatté Adawaye, Joseph Fokam, Erick Kamangu, Hamit Mahamat Alio, Aoudalkarim Moussa Chahad, Fabrice Susin, Ali Mahamat Moussa, Tchombou Hig-Zounet Bertin, Abdelsalam Tidjani, Dolores Vaira, Michel Moutschen
BACKGROUND: The national antiretroviral therapy in the Republic of Chad provides free of charge antiretroviral regimens and therapeutic monitoring for patients receiving antiretroviral therapy nationwide. For a successful programmatic uptake, these efforts merit to be supported by thorough assessments of antiretroviral therapy response and HIV-1 drug resistance surveillance, especially with risks of cross-resistance due to the gradual stavudine phasing out in such national settings. We therefore evaluated the virological response to antiretroviral therapy, HIV-1 drug resistance emergence and circulating HIV-1 clades in a Chad context...
November 10, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29126439/artificial-neural-networks-to-predict-future-bone-mineral-density-and-bone-loss-rate-in-japanese-postmenopausal-women
#13
Mitsunori Shioji, Takehisa Yamamoto, Takeshi Ibata, Takayuki Tsuda, Kazushige Adachi, Noriko Yoshimura
OBJECTIVE: Predictions of the future bone mineral density and bone loss rate are important to tailor medicine for women with osteoporosis, because of the possible presence of personal risk factors affecting the severity of osteoporosis in the future. We investigated whether it was possible to predict bone mineral density and bone loss rate in the future using artificial neural networks. RESULTS: A total of 135 women over 50 years old residing in T town of Wakayama Prefecture, Japan were analyzed to establish a statistical model...
November 10, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29122001/development-of-a-peer-supported-self-management-intervention-for-people-following-mental-health-crisis
#14
Alyssa Milton, Brynmor Lloyd-Evans, Kate Fullarton, Nicola Morant, Bethan Paterson, David Hindle, Kathleen Kelly, Oliver Mason, Marissa Lambert, Sonia Johnson
BACKGROUND: A documented gap in support exists for service users following discharge from acute mental health services, and structured interventions to reduce relapse are rarely provided. Peer-facilitated self-management interventions have potential to meet this need, but evidence for their effectiveness is limited. This paper describes the development of a peer-provided self-management intervention for mental health service users following discharge from crisis resolution teams (CRTs)...
November 9, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29122000/a-foot-care-program-to-facilitate-self-care-by-the-elderly-a-non-randomized-intervention-study
#15
Shizuko Omote, Arisu Watanabe, Tomoko Hiramatsu, Emiko Saito, Masami Yokogawa, Rie Okamoto, Chiaki Sakakibara, Akie Ichimori, Kaoru Kyota, Keiko Tsukasaki
OBJECTIVE: We aimed to evaluate a foot-care awareness program designed to improve foot morphology, physical functioning, and fall prevention among the community-dwelling elderly. Eleven independent community-dwelling elderly women (aged 61-83 years) were provided with foot-care advice and shown effective foot-care techniques to perform regularly for 6 months, and compared with a control group of 10 elderly women who did not receive any intervention. Measurements of foot form, functional capacity, subjective foot movement, and physical function were taken at baseline and 6-month follow-up...
November 9, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29121999/improving-adherence-in-mental-health-service-users-with-severe-mental-illness-in-south-africa-a-pilot-randomized-controlled-trial-of-a-treatment-partner-and-text-message-intervention-vs-treatment-as-usual
#16
Goodman Sibeko, Henk Temmingh, Sumaya Mall, Peter Williams-Ashman, Graham Thornicroft, Ezra S Susser, Crick Lund, Dan J Stein, Peter D Milligan
OBJECTIVES: Medication non-adherence is a significant problem in treatment of severe mental disorders and is associated with poor clinical outcomes and increased demand on services. Task-shifting interventions incorporating mobile health may improve adherence in mental health service users in low- and middle-income countries. Seventy-seven participants were recruited from a psychiatric hospital in Cape Town, with 42 randomized to receive the intervention and 35 to treatment as usual. Intervention pairs underwent treatment-partner contracting and psychoeducation, and received monthly text message reminders of clinic appointments...
November 9, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29121997/family-planning-need-of-people-living-with-hiv-aids-in-antiretroviral-therapy-clinics-of-horro-guduru-wollega-zone-ethiopia
#17
Reta Tsegaye
OBJECTIVE: The purpose of this study was to identify factors associated with family planning needs among people living with human immunodeficiency virus (HIV) in Ethiopia. RESULTS: Three hundred twenty-one participants provided information on family planning methods and associated factors. Forty-six-point four percent of respondents reported using at least one form of family planning method; injectables (50.3%) and condoms (70.2%) were the most commonly used type of family planning method before and after HIV diagnosis, respectively...
November 9, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29121995/round-cell-sarcoma-of-the-colon-with-cic-rearrangement
#18
H Maghrebi, R Batti, A Zehani, N Chrait, H Rais, A Makni, A Haddad, M Ayadi, A Daghfous, M Jrad, N Kchir, Z Bensafta, A Mezlini
BACKGROUND: The CIC-rearranged sarcoma is a very rare highly aggressive malignant soft tissue group of tumors. It has recently been described as highly aggressive soft tissue tumors of children and young adults sharing similar morphological features with the Ewing sarcoma. The digestive localization is exceptional. CASE PRESENTATION: A 14-year-old male presented with a history of abdominal pain for 1 year, which increased in intensity over the last 2 months. Imaging findings showed a large heterogeneous mesenteric mass on the left flank of the abdomen...
November 9, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29121994/dyslipidaemia-in-a-black-african-diabetic-population-burden-pattern-and-predictors
#19
William Lumu, Leaticia Kampiire, George Patrick Akabwai, Richard Ssekitoleko, Daniel Ssekikubo Kiggundu, Davis Kibirige
OBJECTIVES: This study sought to assess the burden, pattern and predictors of dyslipidaemia in 425 adult diabetic patients in Uganda. RESULTS: The median (IQR) age of the study participants was 53 (43.5-62) years with a female majority (283, 66.9%). Dyslipidaemia defined as presence of ≥ 1 lipid abnormalities was observed in 374 (88%) study participants. Collectively, the predictors of dyslipidaemia were: female gender, study site (private hospitals), type of diabetes (type 2 diabetes mellitus), statin therapy, increased body mass index and diastolic blood pressure...
November 9, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29121982/application-of-ultrasound-imaging-biomarkers-histoscanning%C3%A2-improves-staging-reliability-of-prostate-biopsies
#20
M F Hamann, D Meyer, S Knüpfer, J Fuchs, K P Jünemann, C M Naumann
OBJECTIVE: Imaging biomarkers like HistoScanning™ augment the informative value of ultrasound. Analogue image-guidance might improve the diagnostic accuracy of prostate biopsies and reduce misclassifications in preoperative staging and grading. RESULTS: Comparison of 77 image-guided versus 88 systematic prostate biopsies revealed that incorrect staging and Gleason misclassification occurs less frequently in image-guided than in systematic prostate biopsies. Systematic prostate biopsies (4-36 cores, median 12 cores) tended to detect predominantly unilateral tumors (39% sensitivity, 90...
November 9, 2017: BMC Research Notes
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