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BMC Research Notes

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https://www.readbyqxmd.com/read/28931421/magnitude-of-the-cytomegalovirus-infection-among-pregnant-women-attending-antenatal-clinics-in-the-city-of-mwanza-tanzania
#1
Elieza Chibwe, Mariam M Mirambo, Albert Kihunrwa, Stephen E Mshana
BACKGROUND: Despite, Cytomegalovirus (CMV) infection being associated with a potential risk to the fetus, there is limited data from Tanzania and many other developing countries regarding the epidemiology and the impact of CMV infections. This cross-sectional study was conducted between December 2014 and June 2015 among pregnant women attending antenatal clinics in the city of Mwanza, Tanzania to investigate the magnitude and associated factors of CMV infection. METHODS: The specific CMV IgM and IgG antibodies were detected using indirect enzyme linked immunosorbent assay (ELISA)...
September 20, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28931417/sentinel-lymph-node-biopsy-in-periocular-merkel-cell-carcinoma-a-case-report
#2
Dan C Filitis, Gyorgy Paragh, Faramarz H Samie, Nathalie C Zeitouni
BACKGROUND: The National Comprehensive Cancer Network guidelines for Merkel cell carcinoma recommend performance of the sentinel lymph node biopsy in all patients with clinically negative nodal disease for staging and treatment. Nevertheless, sentinel lymph node biopsy in the periocular region is debated as tumors are typically smaller and lymphatic variability can make performance procedurally problematic. CASE PRESENTATION: We present a case of a Caucasian patient in their seventies who presented with a 1...
September 20, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28927444/erratum-to-prevalence-of-methicillin-resistant-staphylococcus-aureus-carriage-on-admission-among-patients-attending-regional-hospitals-in-dar-es-salaam-tanzania
#3
Agricola Joachim, Sabrina J Moyo, Lillian Nkinda, Mtebe Majigo, Elia Mmbaga, Naboth Mbembati, Said Aboud, Eligius F Lyamuya
Following publication of the original article [1], author Elia Mmbaga pointed out that her name had been misspelt as Elia Mbaga.
September 19, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28923121/-i-think-it-is-right-a-qualitative-exploration-of-the-acceptability-and-desired-future-use-of-oral-swab-and-finger-prick-hiv-self-tests-by-lay-users-in-kwazulu-natal-south-africa
#4
Lucia Knight, Tawanda Makusha, Jeanette Lim, Roger Peck, Miriam Taegtmeyer, Heidi van Rooyen
BACKGROUND: The uptake of HIV testing has increased in sub-Saharan Africa over the past three decades. However, the proportion of people aware of their HIV status remains lower than required to change the pandemic. HIV self-testing (HIVST) may meet this gap. Assessment of readiness for and the acceptability of HIVST by lay users in South Africa is limited. This paper presents results from a formative study designed to assess the perceived usability and acceptability of HIVST among lay users using several self-test prototypes...
September 18, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28923097/impact-of-perioperative-nutritional-status-on-the-outcome-of-abdominal-surgery-in-a-sub-saharan-africa-setting
#5
Christian Gael Mambou Tebou, Mazou N Temgoua, Agnès Esiene, Blondel Oumarou Nana, Jean Jacques Noubiap, Eugène Sobngwi
BACKGROUND: Malnutrition is a clinical condition of multifactorial etiologies and it is associated with several adverse outcomes. In high-income countries, malnutrition has been described as a determinant of delayed wound healing, surgical site infections and mortality in the postoperative period. There is limited information available regarding the outcome of surgery in malnourished patients in sub-Saharan Africa. METHODS: A cross-sectional analytic study was carried out between March and August 2014 in the visceral surgery and the emergency departments of the Yaounde Central Hospital in Cameroon...
September 18, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28923092/dubin-johnson-syndrome-and-intrahepatic-cholestasis-of-pregnancy-in-a-sri-lankan-family-a-case-report
#6
Grace Angeline Malarnangai Kularatnam, Hewa Warawitage Dilanthi, Dinesha Maduri Vidanapathirana, Subashini Jayasena, Eresha Jasinge, Ginige Nalika Nirmalenede Silva, Kirinda Liyana Arachchige Manoj Sanjeeva Liyanarachchi, Pujitha Wickramasinghe, Manjit Singh Devgun, Veronique Barbu, Olivier Lascols
BACKGROUND: Dubin-Johnson syndrome and intrahepatic cholestasis of pregnancy are rare chronic liver disorders. Dubin-Johnson syndrome may manifest as conjugated hyperbilirubinemia, darkly pigmented liver, presence of abnormal pigment in the parenchyma of hepatocytes and abnormal distribution of the coproporphyrin isomers I and III in the urine. Intrahepatic cholestatic jaundice of pregnancy presents as pruritus, abnormal liver biochemistry and increased serum bile acids. CASE PRESENTATION: A Sri Lankan girl presented with recurrent episodes of jaundice...
September 18, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28923091/intestinal-parasitic-infections-and-risk-factors-a-cross-sectional-survey-of-some-school-children-in-a-suburb-in-accra-ghana
#7
Akua Obeng Forson, Isaac Arthur, Michael Olu-Taiwo, Kathrine Korkor Glover, Prince Jonathan Pappoe-Ashong, Patrick F Ayeh-Kumi
OBJECTIVE: This study aimed to determine the prevalence and establish some risk factors associated with the acquisition of gastrointestinal parasitic infections in school children in Accra, Ghana. RESULTS: The overall prevalence of intestinal parasitic infection was 15%. Giardia lamblia (10%) and Schistosoma mansoni (1.7%) were the common parasites found. Out of the 15% students postive for intestinal parasites, 13.6% had single parasites and 1.3% had double parasitic infections...
September 18, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28915916/effects-of-a-silent-mentor-initiation-ceremony-and-dissection-on-medical-students-humanity-and-learning
#8
Ruei-Jen Chiou, Po-Fang Tsai, Der-Yan Han
OBJECTIVES: Many medical schools in Taiwan have adopted a dignified "silent mentor" initiation ceremony to strengthen student's medical humanity and increase their learning attitudes. This ceremony consists of introductions of the body donor's conduct and deeds, wreath-laying, and a tea party. However, few empirical studies have examined the influences of the ceremony and dissection on medical humanity. This study explored if the initiation ceremony and the course can help students care more about others, develop more positive attitudes toward death, improve learning effectiveness in the course, and decrease negative emotions the first time they see a cadaver...
September 16, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28915911/timing-rather-than-user-traits-mediates-mood-sampling-on-smartphones
#9
Beryl Noë, Liam D Turner, David E J Linden, Stuart M Allen, Gregory R Maio, Roger M Whitaker
OBJECTIVE: Recent years have seen an increasing number of studies using smartphones to sample participants' mood states. Moods are usually collected by asking participants for their current mood or for a recollection of their mood states over a specific period of time. The current study investigates the reasons to favour collecting mood through current or daily mood surveys and outlines design recommendations for mood sampling using smartphones based on these findings. These recommendations are also relevant to more general smartphone sampling procedures...
September 16, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28915823/patients-with-acute-poisoning-presenting-to-an-urban-emergency-department-of-a-tertiary-hospital-in-tanzania
#10
Ghaniya S Mbarouk, Hendry R Sawe, Juma A Mfinanga, John Stein, Shankar Levin, Victor Mwafongo, Michael S Runyon, Teri A Reynolds, Kent R Olson
BACKGROUND: Poisoning is a major public health concern in sub-Saharan Africa, affecting patients of all age groups. Poisoned patients often present to the emergency department (ED) and prompt evaluation and appropriate management are imperative to ensure optimal outcomes. Unfortunately, little is known about the specific presentations of poisoned patients in East Africa. We describe the clinical and epidemiological features of patients presenting to the Muhimbili National Hospital (MNH) ED with suspected toxicological syndromes...
September 16, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28915836/changes-in-dna-methylation-in-na%C3%A3-ve-t-helper-cells-regulate-the-pathophysiological-state-in-minimal-change-nephrotic-syndrome
#11
Yasuko Kobayashi, Akira Aizawa, Takumi Takizawa, Katsuhide Igarashi, Izuho Hatada, Hirokazu Arakawa
BACKGROUND: DNA methylation plays a crucial role in regulating transcription, and changes in DNA methylation affect gene expression and disease development. Minimal change nephrotic syndrome (MCNS) has been reported to involve immunological disturbances. Since the characteristic features of the disease include recurrent relapse and sex and age preference, the disease pathogenesis may be partly related to epigenetic changes. However, little is known about these changes. METHODS: We analyzed genome-wide DNA methylation using the microarray-based integrated analysis of methylation by isoschizomers method...
September 15, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28903776/facilitatory-effect-of-insulin-treatment-on-hepatocellular-carcinoma-development-in-diabetes
#12
Hayato Baba, Makoto Kurano, Takeshi Nishida, Hideki Hatta, Ryoji Hokao, Koichi Tsuneyama
BACKGROUND: To evaluate the effect of insulin treatment on the incidence and/or severity of hepatocellular carcinoma (HCC) in a mouse model of HCC based on diabetes. METHODS: We recently reported that neonatal streptozotocin (STZ) treatment causes type 1 diabetes and subsequent HCC in ddY, Institute for Animal Reproduction (DIAR) mice. Newborn male DIAR mice were divided into three groups based on STZ and insulin (INS) treatment. STZ was subcutaneously injected (60 mg/g) into the STZ-treated group (DIAR-nSTZ mice, N = 13) and the STZ/insulin-treated group (DIAR-nSTZ/INS mice, N = 20)...
September 13, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28903752/measurement-of-cortisol-in-saliva-a-comparison-of-measurement-error-within-and-between-international-academic-research-laboratories
#13
Jessica L Calvi, Frances R Chen, Victoria Brann Benson, Eleanor Brindle, Matt Bristow, Alpana De, Sonja Entringer, Helen Findlay, Christine Heim, Eric A Hodges, Heiko Klawitter, Sonia Lupien, Holly M Rus, Jitske Tiemensma, Silvanna Verlezza, Claire-Dominique Walker, Douglas A Granger
OBJECTIVE: Hundreds of scientific publications are produced annually that involve the measurement of cortisol in saliva. Intra- and inter-laboratory variation in salivary cortisol results has the potential to contribute to cross-study inconsistencies in findings, and the perception that salivary cortisol results are unreliable. This study rigorously estimates sources of measurement variability in the assay of salivary cortisol within and between established international academic-based laboratories that specialize in saliva analyses...
September 13, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28899432/prevalence-and-associations-of-microalbuminuria-in-proteinuria-negative-patients-with-type-2-diabetes-in-two-regional-hospitals-in-cameroon-a-cross-sectional-study
#14
Nelsy T Efundem, Jules Clement N Assob, Vitalis F Feteh, Simeon-Pierre Choukem
BACKGROUND: Microalbuminuria (MA) is the earliest clinical evidence of diabetic nephropathy, but most patients in sub-Saharan Africa (SSA) only have access to much cheaper dipstick proteinuria as a means to screen for diabetic nephropathy. The aim of this study was to determine the prevalence and associations of MA among proteinuria-negative type 2 diabetic patients in a SSA setting. METHODS: In this cross-sectional study, patients with type 2 diabetes screened negative for dipstick proteinuria in a primary healthcare hospital were assessed...
September 12, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28899405/neonatal-hemolytic-anemia-does-not-always-indicate-thalassemia-a-case-report
#15
Arwa A Al-Harazi, Bilguis M Al-Eryani, Butheinah A Al-Sharafi
BACKGROUND: Congenital erythropoietic porphyria is a rare autosomal recessive disorder that affects heme-porphyrin synthesis. This disorder is due to the genetic defect of uroporphyrinogen III cosynthase. This defect results in the accumulation of high amounts of uroporphyrin I in all tissues, leading to clinical manifestations ranging from mild to severe chronic damage of the skin, cartilage and bone. Hypertrichosis, erythrodontia and reddish-colored urine are often present, as well as hemolytic anemia accompanied by hepatosplenomegaly...
September 12, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28899398/associations-of-two-pore-domain-potassium-channels-and-triple-negative-breast-cancer-subtype-in-the-cancer-genome-atlas-systematic-evaluation-of-gene-expression-and-methylation
#16
Keith A Dookeran, Wei Zhang, Leslie Stayner, Maria Argos
OBJECTIVES: It is unclear whether 2-pore domain potassium channels are novel molecular markers with differential expression related to biologically aggressive triple-negative type breast tumors. Our objective was to systematically evaluate associations of 2-pore domain potassium channel gene expression and DNA methylation with triple-negative subtype in The Cancer Genome Atlas invasive breast cancer dataset. Methylation and expression data for all fifteen 2-pore domain potassium family genes were examined for 1040 women, and associations with triple-negative subtype (vs...
September 12, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28893321/prevalence-and-trends-in-transmitted-and-acquired-antiretroviral-drug-resistance-washington-dc-1999-2014
#17
Annette M Aldous, Amanda D Castel, David M Parenti
BACKGROUND: Drug resistance limits options for antiretroviral therapy (ART) and results in poorer health outcomes among HIV-infected persons. We sought to characterize resistance patterns and to identify predictors of resistance in Washington, DC. METHODS: We analyzed resistance in the DC Cohort, a longitudinal study of HIV-infected persons in care in Washington, DC. We measured cumulative drug resistance (CDR) among participants with any genotype between 1999 and 2014 (n = 3411), transmitted drug resistance (TDR) in ART-naïve persons (n = 1503), and acquired drug resistance (ADR) in persons with genotypes before and after ART initiation (n = 309)...
September 11, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28886746/prevalence-of-antibodies-to-brucella-species-in-commercial-raw-bovine-milk-in-southwestern-uganda
#18
Monicah Kamwine, Patrick Orikiriza, Kabanda Taseera, Jacob Stanley Iramiot, Patrick Ojuka, Steven Ikiriza, Jeninah Atwebembeire, Duncan Otieno, Silver Tweshengyereze, Juliet Mwanga-Amumpaire, Joel Bazira, Yap Boum
OBJECTIVES: The purpose and objective of this research was to explore the prevalence of antibodies against Brucella species in raw milk samples collected in Southwestern Uganda, one of the biggest milk producing regions in the Country. We hypothesized that there is a high level of antibodies in milk samples from this region. This builds more evidence to other studies in the region on the level contamination of raw milk. RESULTS: A total of 185 raw milk samples, collected from dairy farms and factories in southwestern region, were tested for antibodies to Brucella spp...
September 8, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28886731/effects-of-bacitracin-methylene-disalicylate-and-diet-change-on-gastrointestinal-integrity-and-endotoxin-permeability-in-the-duodenum-of-broiler-chicken
#19
Dawn A Koltes, Howard D Lester, Maurice Frost, Douglas Aldridge, Karen D Christensen, Colin G Scanes
OBJECTIVE: To determine the effect of bacitracin methylene disalicylate (BMD) and feed changes on gastrointestinal integrity, endotoxin permeability, and morphometric parameters in the duodenum of broilers. RESULTS: Birds were raised on a starter diet without growth promoting antibiotics for 31 days then switched to a grower diet. Four of the pens including 50 g/ton of BMD while 4 pens remained antibiotic free. Eight birds per treatment were sampled prior to the feed change and at 3 and 7 days following the feed change...
September 8, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28886729/evaluation-of-xpert-mtb-rif-testing-for-rapid-diagnosis-of-childhood-pulmonary-tuberculosis-in-children-by-xpert-mtb-rif-testing-of-stool-samples-in-a-low-resource-setting
#20
Zahra Hasan, Sadia Shakoor, Fehmina Arif, Aisha Mehnaz, Alnoor Akber, Marium Haider, Akbar Kanji, Rumina Hasan
OBJECTIVE: Children with tuberculosis (TB) remain underdiagnosed due to difficulty in testing for Mycobacterium tuberculosis (MTB) infection. We evaluated the Xpert MTB/RIF assay for respiratory and stool testing in children for pulmonary TB through a cross-sectional study at tertiary care facilities in Karachi, Pakistan. Fifty children aged 0-15 years screened by a modified Kenneth-Jones (KJ) score were included. Mycobacterial culture of respiratory samples was the microbiological standard against stool Xpert TB results...
September 8, 2017: BMC Research Notes
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