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BMC Research Notes

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https://www.readbyqxmd.com/read/29776452/work-related-musculoskeletal-disorders-among-registered-general-nurses-a-case-of-a-large-central-hospital-in-harare-zimbabwe
#1
M Chiwaridzo, V Makotore, J M Dambi, N Munambah, M Mhlanga
OBJECTIVE: Worldwide, work-related musculoskeletal disorders (WMSDs) are a common cause of morbidity affecting occupational individuals such as health-care professionals. However, nothing is known about WMSDs in hospital nurses in Zimbabwe. This study was conducted to provide cross-sectional evidence of the 12-month prevalence, consequences and factors associated with WMSDs among 208 nurses at Parirenyatwa Group of Hospitals (PGH). RESULTS: The response rate for the study was 55...
May 18, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29776449/imipenem-resistance-in-clinical-escherichia-coli-from-qom-iran
#2
Saeed Shams, Ali Hashemi, Mohammad Esmkhani, Somaye Kermani, Elham Shams, Alessandra Piccirillo
OBJECTIVE: The emergence of metallo-β-lactamase-producing Enterobacteriaceae is a worldwide health concern. In this study, the first evaluation of MBL genes, bla IMP and bla VIM , in Escherichia coli resistant to imipenem isolated from urine and blood specimens in Qom, Iran is described. Three hundred urine and blood specimens were analysed to detect the presence of E. coli. Resistance to imipenem and other antimicrobials was determined by disk diffusion and MIC. MBL production was screened using CDDT...
May 18, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29776448/anti-plasmodial-activities-of-combretum-molle-combretaceae-zwoo-seed-extract-in-swiss-albino-mice
#3
Merkin Anato, Tsige Ketema
OBJECTIVE: Objective of the study was to evaluate in vivo anti-plasmodial activities of Combretum molle seed extract. METHODS: As a standard protocol, initially the acute toxicity of the plant seed extract was checked following single administration of crude seed extract of the plant at doses 500, 1000 and 2000 mg/kg. This was followed by evaluation of anti-plasmodial activity of crude seed extract of the plant following a 4 days suppressive test. RESULTS: In acute toxicity study sign of toxicity was not observed...
May 18, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29776447/factors-associated-with-glycemic-control-among-diabetic-adult-out-patients-in-northeast-ethiopia
#4
Temesgen Fiseha, Ermiyas Alemayehu, Wongelawit Kassahun, Aderaw Adamu, Angesom Gebreweld
OBJECTIVE: The aim of this study was to determine the status of glycemic control and identify factors associated with poor glycemic control among diabetic out-patients. RESULTS: A hospital based cross-sectional study was conducted among randomly selected 384 (126 type 1 and 258 type 2) diabetic adults attending a hospital in Northeast Ethiopia from January 1 to April 30, 2017. Of the total participants, 70.8% had poor status of glycemic control (defined as mean fasting blood glucose level above 130 mg/dl)...
May 18, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29776445/community-based-audits-of-snake-envenomations-in-a-resource-challenged-setting-of-cameroon-case-series
#5
Frank-Leonel Tianyi, Valirie Ndip Agbor, Joel Noutakdie Tochie, Benjamin Momo Kadia, Armand Seraphin Nkwescheu
BACKGROUND: Snakebites are a major cause of mortality and morbidity worldwide with the highest mortality burden in poor rural areas of sub-Saharan Africa. Inadequate surveillance systems result in loss of morbidity and mortality data in these settings. Although rarely reported in these resource-constraint environments, community-based audits are recognised pivotal tools which could help update existing data and indicate key public health interventions to curb snakebite-related mortality...
May 18, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29776441/patients-expectation-strongly-associated-with-patients-perception-to-nursing-care-hospital-based-cross-sectional-study
#6
Alem Girmay, Tekleweyni Marye, Mebrahtu Haftu, Dawit G/Her, Tsion Brhanu, Hadgu Gerensea
OBJECTIVE: Nursing care is one of the most important components of health care and patient expectation toward nursing care is being rising. Accordingly, patients' expectation needs to be managed adequately in order to improve outcomes and decrease liability through their perception. To improve the outcome based on the expectation of patients, we need to consider patients' perception to the care they received. So this study aims to identifies the perceptions toward nursing care and their associated factors...
May 18, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29776438/uninterrupted-monitoring-of-drug-effects-in-human-induced-pluripotent-stem-cell-derived-cardiomyocytes-with-bioluminescence-ca-2-microscopy
#7
Kazushi Suzuki, Takahito Onishi, Chieko Nakada, Shunsuke Takei, Matthew J Daniels, Masahiro Nakano, Tomoki Matsuda, Takeharu Nagai
OBJECTIVE: Cardiomyocytes derived from human-induced pluripotent stem cells are a powerful platform for high-throughput drug screening in vitro. However, current modalities for drug testing, such as electrophysiology and fluorescence imaging have inherent drawbacks. To circumvent these problems, we report the development of a bioluminescent Ca2+ indicator GmNL(Ca2+ ), and its application in a customized microscope for high-throughput drug screening. RESULTS: GmNL(Ca2+ ) gives a 140% signal change with Ca2+ , and can image drug-induced changes of Ca2+ dynamics in cultured cells...
May 18, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29776433/bordetella-pertussis-in-children-hospitalized-with-a-respiratory-infection-clinical-characteristics-and-pathogen-detection-in-household-contacts
#8
Juana Del Valle-Mendoza, Wilmer Silva-Caso, Miguel Angel Aguilar-Luis, Cristina Del Valle-Vargas, Erico Cieza-Mora, Johanna Martins-Luna, Ronald Aquino-Ortega, Andrea Silva-Vásquez, Jorge Bazán-Mayra, Pablo Weilg
OBJECTIVE: Describe the prevalence of Bordetella pertussis via PCR in children under 5 years old hospitalized as probable cases of pertussis and report the most common clinical features among them. RESULTS: A positive PCR result for B. pertussis was observed in 20.5% of our samples (18/88), one-third of them were from infants between 2 and 3 months old. The most common symptoms were paroxysms of coughing (88.9%), difficulty breathing (72.2%), cyanosis (77.8%) and fever (50%)...
May 18, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29776430/recurrent-bilateral-mycobacterium-bovis-necrotizing-epididymitis-a-case-report
#9
Simon Grandjean-Lapierre, Simon-Djamel Thiberville, Mustapha Fellag, Christophe Eghazarian, Feriel Bouzid, Christina Gavril, Michel Drancourt
BACKGROUND: Mycobacterium bovis causing tuberculosis in animals is responsible for zoonotic tuberculosis in patients. Veterinary control measures and milk pasteurization has led to a significant decrease in human cases of M. bovis infections in developed countries. CASE PRESENTATION: We diagnosed recurrent M. bovis epididymitis in a 63-year old Caucasian man without any signs of pulmonary or disseminated disease. Relevant epidemiological expositions included camel milk drinking during prolonged travels in Niger, prior to initial clinical manifestations...
May 18, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29776426/detection-of-zika-virus-infection-among-asymptomatic-pregnant-women-in-the-north-of-peru
#10
Claudia Weilg, Lucinda Troyes, Zoila Villegas, Wilmer Silva-Caso, Fernando Mazulis, Ammy Febres, Mario Troyes, Miguel Angel Aguilar-Luis, Juana Del Valle-Mendoza
OBJECTIVE: To report an outbreak of ZIKV infection among asymptomatic pregnant women during 2016 in the city of Jaen, Cajamarca. RESULTS: Zika virus RNA was detected in 3.2% (n = 36) of cases by RT-PCR. The mean age of patients positive for ZIKV infection was 29.6 years. 7 patients (19.4%) infected with ZIKV were in their first-trimester of gestation, 13 (36.1%) were in their second-trimester, and 16 (44%) were in their third-trimester. All of the infected pregnant women were asymptomatic...
May 18, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29776372/curation-of-microarray-oligonucleotides-and-corresponding-ests-cdnas-used-for-gene-expression-analysis-in-zebra-finches
#11
Peter V Lovell, Nicole A Huizinga, Abel Getachew, Brianna Mees, Samantha R Friedrich, Morgan Wirthlin, Claudio V Mello
OBJECTIVES: Zebra finches are a major model organism for investigating mechanisms of vocal learning, a trait that enables spoken language in humans. The development of cDNA collections with expressed sequence tags (ESTs) and microarrays has allowed for extensive molecular characterizations of circuitry underlying vocal learning and production. However, poor database curation can lead to errors in transcriptome and bioinformatics analyses, limiting the impact of these resources. Here we used genomic alignments and synteny analysis for orthology verification to curate and reannotate ~ 35% of the oligonucleotides and corresponding ESTs/cDNAs that make-up Agilent microarrays for gene expression analysis in finches...
May 18, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29769149/hypertension-and-its-associated-factors-in-hosanna-town-southern-ethiopia-community-based-cross-sectional-study
#12
Likawunt Samuel Asfaw, Samuel Yohannes Ayanto, Fiseha Laemengo Gurmamo
OBJECTIVES: This study was conducted to determine the prevalence of hypertension and its associated factors among residents of Hosanna town in Hadiya Zone. RESULTS: The overall prevalence of hypertension was 30% among the study participants. Out of the study participants who were identified as being hypertensive, only 24.6% knew their hypertensive status. The odds of being hypertensive is significantly higher among males when compared to females (adjusted odds ratio (AOR) 1...
May 16, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29769118/protection-against-neonatal-enteric-colibacillosis-employing-e-coli-derived-outer-membrane-vesicles-in-formulation-and-without-vitamin-d3
#13
Babak Beikzadeh, Gholamreza Nikbakht Brujeni
OBJECTIVE: Enterotoxigenic Escherichia Coli (ETEC) is the cause of diarrhea and even death in humans and offspring of animals. Outer membrane vesicles (OMVs) of the ETEC was prepared and its potential as a vaccine candidate against enteric colibacillosis in neonatal mice was evaluated. Dam mice intradermally injected with ETEC-derived OMVs and OMVs plus an active form of vitamin D3 (avD3). Mucosal and systemic immune responses in mice and passive immunity protection against ETEC lethality in their offspring was investigated...
May 16, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29769111/predictors-of-back-disorder-among-almeda-textile-factory-workers-north-ethiopia
#14
Teklehaymanot Huluf Abraha, Asmelash Tekie Demoz, Haimanot Gebrehiwot Moges, Ansha Nega Ahmmed
OBJECTIVES: To guide the development of targeted interventions for the prevention of work-related back pain, this manuscript estimates the prevalence of back pain and its association with a variety of risk factors among Almeda textile factory production works from March to April 2015. An institutional-based cross-sectional study was carried out in Almeda textile factory, North Ethiopia. Randomly selected workers were administered a structured questionnaire about their socio-economic status, lifestyle, working conditions, back pain and selected risk factors...
May 16, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29769110/prevalence-and-determinants-of-selected-cardio-metabolic-risk-factors-among-people-living-with-hiv-aids-and-receiving-care-in-the-south-west-regional-hospitals-of-cameroon-a-cross-sectional-study
#15
Roland Cheofor Ngu, Simeon-Pierre Choukem, Christian Akem Dimala, Julius N Ngu, Gottlieb Lobe Monekosso
OBJECTIVE: Metabolic disorders and cardiovascular risk factors are not routinely assessed in the care of HIV patients in developing countries, known to have the highest disease burden. We described the prevalence and factors associated with major cardio-metabolic risk factors (obesity, diabetes and hypertension) in HIV/AIDS patients. RESULTS: The prevalence of diabetes, hypertension and obesity were 11.3% (95% CI 8.10-15.43), 24.8% (95% CI 20.1-30.0) and 14.5% (95% CI 11...
May 16, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29769094/screening-of-melatonin-%C3%AE-tocopherol-folic-acid-acetyl-l-carnitine-and-resveratrol-for-anti-dengue-2-virus-activity
#16
Atchara Paemanee, Atitaya Hitakarun, Sittiruk Roytrakul, Duncan R Smith
OBJECTIVE: Infections with the mosquito transmitted dengue virus (DENV) are a significant public health burden in many parts of the world. Despite the introduction of a commercial vaccine in some parts of the world, the majority of the populations at risk of infection remain unprotected against this disease, and there is currently no treatment for DENV infection. Natural compounds offer the prospect of cheap and sustainable therapeutics to reduce the disease burden during infection, and thus potentially alleviate the risk of more severe disease...
May 16, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29769093/granulomatosis-with-polyangiitis-a-17-year-experience-from-a-tertiary-care-hospital-in-pakistan
#17
Omar Irfan, Haris Khan, Zarrar Khan, Alina Ashraf, Rimsha Ahmed, Javaid Ahmad Khan, Ali Bin Sarwar Zubairi
OBJECTIVE: Granulomatosis with Polyangiitis (GPA) is an autoimmune, multi-system, small and medium vessel vasculitis with granulomatous inflammation. Aim of this study was to assess the clinical and radiological presentations of patients with GPA amongst the Pakistani population. It is a single centre retrospective single observation study. RESULTS: Study was conducted at the Aga Khan University Hospital, Karachi with records were reviewed from January 2000 to December 2017...
May 16, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29764512/mutational-analysis-of-two-residues-in-the-dyrk-homology-box-of-the-protein-kinase-dyrk1a
#18
Esti Wahyu Widowati, Simone Bamberg-Lemper, Walter Becker
OBJECTIVE: Dual specificity tyrosine phosphorylation-regulated kinases (DYRK) contain a characteristic sequence motif (DYRK homology box, DH box) that is located N-terminal of the catalytic domain and supports the autophosphorylation of a conserved tyrosine during maturation of the catalytic domain. Two missense mutations in the DH box of human DYRK1B were recently identified as causative of a rare familiar form of metabolic syndrome. We have recently shown that these amino acid exchanges impair maturation of the kinase domain...
May 15, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29764503/bacteriological-profile-of-neonatal-sepsis-and-antibiotic-susceptibility-pattern-of-isolates-admitted-at-kanti-children-s-hospital-kathmandu-nepal
#19
Nikita Singh Yadav, Saroj Sharma, Dhiraj Kumar Chaudhary, Prabhat Panthi, Pankaj Pokhrel, Anil Shrestha, Pappu Kumar Mandal
OBJECTIVE: Neonatal sepsis is a major cause of morbidity and mortality of newborns (< 1 month of age). Septicemia and drug resistance is a predominant issue for neonatal death in Nepal. This study is intended to find bacteriological profile of neonatal sepsis and antibiotic susceptibility pattern of the isolates from neonates at Kanti Children's Hospital, Kathmandu, Nepal. RESULTS: Out of 350 suspected cases of neonatal sepsis, 59 (16.9%) cases showed positive blood culture...
May 15, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29764489/mir-magic-improves-quantification-accuracy-for-small-rna-seq
#20
Pamela H Russell, Brian Vestal, Wen Shi, Pratyaydipta D Rudra, Robin Dowell, Richard Radcliffe, Laura Saba, Katerina Kechris
OBJECTIVE: Many tools have been developed to profile microRNA (miRNA) expression from small RNA-seq data. These tools must contend with several issues: the small size of miRNAs, the small number of unique miRNAs, the fact that similar miRNAs can be transcribed from multiple loci, and the presence of miRNA isoforms known as isomiRs. Methods failing to address these issues can return misleading information. We propose a novel quantification method designed to address these concerns. RESULTS: We present miR-MaGiC, a novel miRNA quantification method, implemented as a cross-platform tool in Java...
May 15, 2018: BMC Research Notes
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