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BMC Research Notes

Anthony I Ajayi, Wilson Akpan
OBJECTIVES: There appears to be an increasing trend of condom use for pregnancy prevention among nulliparous and multiparous women in developing countries. Drawing from a cross-sectional survey involving 1227 women selected using a 3-stage cluster random sampling technique, the study examines the rates of condom use and its determinants among parous women in three states in North Central and South Western Nigeria. RESULTS: The rate of condom use among parous women was 13...
July 13, 2018: BMC Research Notes
Rita F Tamambang, Tsi Njim, Albertine E Njie, Lawrence Mbuagbaw, Agnès Mafuta, Mesack Tchana, Simeon-Pierre Choukem
OBJECTIVE: Adolescent deliveries remain a public health problem in most developing countries. The aim of our study was to determine the prevalence, trends and outcome of adolescent deliveries in an urban setting in Cameroon. We carried out a retrospective register analysis over a 6-year period (January 2010-December 2015) at the Saint Albert Le Grand hospital Douala. RESULTS: The overall prevalence of adolescent deliveries was 8.2% (662 out of 8056). There was a significant decrease over the 6-year period (p-trend: < 0...
July 13, 2018: BMC Research Notes
Rui Tada, Akira Hidaka, Hiroshi Kiyono, Jun Kunisawa, Yukihiko Aramaki
OBJECTIVE: Infectious diseases remain a threat to human life. Vaccination against pathogenic microbes is a primary method of treatment as well as prevention of infectious diseases. Particularly mucosal vaccination is a promising approach to fight against most infectious diseases, because mucosal surfaces are a major point of entry for most pathogens. We recently developed an effective mucosal adjuvant of cationic liposomes composed of 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) and 3β-[N-(N',N'-dimethylaminoethane)-carbamoyl] (DC-chol) (DOTAP/DC-chol liposomes)...
July 13, 2018: BMC Research Notes
Dissinviel S Kpoda, Abraham Ajayi, Marius Somda, Oumar Traore, Nathalie Guessennd, Aboubakar S Ouattara, Lassana Sangare, Alfred S Traore, Mireille Dosso
OBJECTIVE: Resistance to antibiotics most especially third generation cephalosporins has assumed a worrisome dimension globally. Genes conferring these resistance which are mediated by enzymes known as extended spectrum beta-lactamases (ESBLs) are now wide spread among several Enterobacteriaceae species. However there is paucity of data regarding the distribution of these genes in Burkina Faso. Hence this prospective study aims to determine the prevalence and distribution of ESBL encoding genes in ESBL producing Enterobacteriaceae strains isolated from clinical samples of patients attending the three major hospitals in Ouagadougou Burkina Faso...
July 13, 2018: BMC Research Notes
David Etsey Akpakli, Alfred Kwesi Manyeh, Jonas Kofi Akpakli, Vida Kukula, Margaret Gyapong
OBJECTIVE: Access to improved sanitation facilities is critical to the health and well-being of individuals and communities. However, globally, over 2.5 billion people live without access to safe sanitation facilities and more than 40% of the world population, do not use a toilet, but defecate in the open or in unsanitary places. In Ghana, only 14% of the population have access to improved sanitation facilities with great disparities between rural (8%) and urban (19%) dwellers. This paper sought to examine the determinants of access to improved sanitation facilities by households among rural dwellers in two districts in southern Ghana...
July 13, 2018: BMC Research Notes
Araceli Benavides-Ward, Fernando Vasquez-Achaya, Wilmer Silva-Caso, Miguel Angel Aguilar-Luis, Fernando Mazulis, Numan Urteaga, Juana Del Valle-Mendoza
OBJECTIVE: To determine the variations in the composition of the intestinal microbiota in asymptomatic children infected with Helicobacter pylori in comparison with children without the infection. RESULTS: Children infected with H. pylori doubled their probability of presenting 3 of 9 genera of bacteria from the gut microbiota, including: Proteobacteria (p = 0.008), Clostridium (p = 0.040), Firmicutes (p = 0.001) and Prevotella (p = 0.006) in comparison to patients without the infection...
July 13, 2018: BMC Research Notes
Tyler A Herek, Jacob E Robinson, Tayla B Heavican, Catalina Amador, Javeed Iqbal, Christine E Cutucache
OBJECTIVE: Caveolin-1 (CAV1) is known for its role as both a tumor suppressor and an oncogene, harboring a highly context-dependent role within a myriad of malignancies and cell types. In an immunological context, dysregulation of CAV1 expression has been shown to alter immunological signaling functions and suggests a pivotal role for CAV1 in the facilitation of proper immune responses. Nonetheless, it is still unknown how Cav1-deficiency and heterozygosity would impact the development and composition of lymphoid organs in mice...
July 13, 2018: BMC Research Notes
Jayaweera Arachchige Asela Sampath Jayaweera, Anpalaham Joseph
OBJECTIVES: Military personnel, because of the unique nature of their duties, are reluctant to face stressors. Living in hot and humid conditions they frequently suffer dehydration. Army soldiers living in dry zone of Sri Lanka, were screened for chronic kidney disease (CKD), common non-communicable diseases and methicillin resistant Staphylococcus aureus (MRSA) colonization. Albumin creatinine ratio > 30 mg/g urine taken as cut-off for detection of CKD. RESULTS: Screened 417 soldiers, all were men and body mass index were 21...
July 13, 2018: BMC Research Notes
Jinuraj K R, Rakhila M, Dhanalakshmi M, Sajeev R, Akshata Gad, Jayan K, Muhammed Iqbal P, Andrew Titus Manuel, Abdul Jaleel U C
OBJECTIVES: The primary goal of this experiment is to prioritize molecular descriptors that control the activity of active molecules that could reduce the dimensionality produced during the virtual screening process. It also aims to: (1) develop a methodology for sampling large datasets and the statistical verification of the sampling process, (2) apply screening filter to detect molecules with polypharmacological or promiscuous activity. RESULTS: Sampling from large a dataset and its verification were done by applying Z-test...
July 13, 2018: BMC Research Notes
Ignatius Wadunde, Doreen Tuhebwe, Michael Ediau, Gildo Okure, Arthur Mpimbaza, Rhoda K Wanyenze
OBJECTIVES: This study was set out to assess the level of adherence to antiretroviral therapy (ART) and its determinants among children receiving HIV treatment in Kabale district, south western Uganda, in order to inform interventions for improving pediatric ART adherence. RESULTS: Overall, 79% (121/153) of the children did not miss ART doses over the 7 days. Caregiver forgetfulness was the major reason for missing ART doses, 37% (13/35). Other reasons included transportation costs to the health facilities, 17%, (6/35) and children sitting for examinations in schools...
July 13, 2018: BMC Research Notes
Carolina Geadas, Carlos Acuna-Villaorduna, Gustavo Mercier, Mary B Kleinman, C Robert Horsburgh, Jerrold J Ellner, Karen R Jacobson
OBJECTIVE: Mycobacterium tuberculosis infection leads to latent or active tuberculosis (TB). Increased uptake on 18 F-fluoro-2-deoxy-glucose-positron emission tomography/computed tomography (FDG-PET/CT) has been reported in the lungs and lymph nodes of individuals with recent infection and active TB, but not in individuals without known recent exposure or suggestive symptoms. We describe five patients with lung nodules not suspected to be due to TB in whom abnormalities on FDG-PET/CT scans ultimately were attributed to TB infection...
July 13, 2018: BMC Research Notes
Firew Tekle Bobo, Mirkuzie Woldie, Muluemebet Abera Wordofa, Gebeyehu Tsega, Tesfamichael Alaro Agago, Kifle Wolde-Michael, Nuraddis Ibrahim, Elias Ali Yesuf
OBJECTIVE: The aim of the study was to measure technical and scale efficiency of public health centers in three districts of Jimma zone, Ethiopia. A two-stage data envelopment analysis was used. First, we estimated technical and scale efficiency of the health centers. In the second stage, institutional and environmental factors were against technical efficiency of the health centers to identify factors associated to efficiency of the health centers. RESULTS: Eight out of the 16 health centers in the study were found to be technically efficient, with an average score of 90% (standard deviation = 17%)...
July 13, 2018: BMC Research Notes
Hunaina Shahab, Hamza Sohail Khan, Aysha Almas, Mayera Tufail, Khawar Abbas Kazmi, Aamir Hameed Khan
OBJECTIVE: Our previous study showed that post-clinic blood pressure (BP) taken 15 min after a physician-patient encounter was the lowest reading in a routine clinic. We aimed to validate this reading with 24 h Ambulatory Blood Pressure Monitoring (ABPM) readings. A cross-sectional study was conducted in the cardiology clinics at the Aga Khan University, Pakistan. Hypertensive patients aged ≥ 18 years, or those referred for the diagnosis of hypertension were included. RESULTS: Of 150 participants, 49% were males...
July 11, 2018: BMC Research Notes
Razvan C Stan, Francisco G Soriano, Maristela M de Camargo
OBJECTIVE: Oscillations of physiological parameters describe many biological processes and their modulation is determinant for various pathologies. In sepsis, toll-like receptor 4 (TLR4) is a key sensor for signaling the presence of Gram-negative bacteria. Its intracellular trafficking rates shift the equilibrium between the pro- and anti-inflammatory downstream signaling cascades, leading to either the physiological resolution of the bacterial stimulation or to sepsis. This study aimed to evaluate the effects of TLR4 increased expression and intracellular trafficking on the course and outcome of sepsis...
July 11, 2018: BMC Research Notes
Valirie Ndip Agbor, Claude Tayou Tagny, Jules-Bertrand Kenmegne, Bih Awazi, Charlotte Ngansop, Dora Mbanya, Nicaise Ndembi
OBJECTIVE: To evaluate the prevalence of the co-infection between the human immunodeficiency virus (HIV) and hepatitis C virus (HCV), and the prevalence of factors associated with HCV transmission in a rural Cameroonian community. RESULTS: The mean age of the 174 participants included in the study was 30.3 (standard deviation = 13.26) years (age range 12-77 years). the prevalence of HCV/HIV co-infection was 1.7% [95% confidence interval (CI) 1.1-5.9]. The prevalence of HCV and HIV were 6...
July 11, 2018: BMC Research Notes
P G González-Pech, J F J Torres-Acosta, C A Sandoval-Castro
OBJECTIVE: To validate the estimation of dry matter intake (DMI) obtained from bite categories (BC) and weight for every plant species (method 1: M1) vs. an alternative method (method 2: M2) grouping plants based on structure and leaf morphology. A dataset containing 80,813 bites and 33 plant species obtained by M1 for sheep and goats browsing a tropical forest was used. Plant species and their respective bite weight were regrouped according to M2. BC weights within each morphological group were compared using ANOVA and post hoc Tukey's honest significant difference comparisons...
July 11, 2018: BMC Research Notes
Atif Ali Hashmi, Mahrukh Faraz, Zareeha Nauman, Muhammad Usman Qureshi, Shumaila Kanwal Hashmi, Hira Fatima Waseem, Muhammad Muzzammil Edhi, Naveen Faridi, Amir Khan
OBJECTIVES: Gastrointestinal stromal tumors (GISTs) are rare tumors of gastrointestinal tract, prognosis of which largely depends upon histopathologic characteristics of resection specimens, which were not widely studied in our population. Therefore we aimed to evaluate the histopathologic characteristics of GISTs in our population and their prognostic grouping according to college of American pathologist's guidelines. RESULTS: Mean age of patients was 53.4 years (18-71 years)...
July 11, 2018: BMC Research Notes
Carolina Senra, Luciana Inácia Gomes, Liliane Maria Vidal Siqueira, Paulo Marcos Zech Coelho, Ana Rabello, Edward Oliveira
OBJECTIVE: We developed a laboratorial platform to release a commercial platform used in the PCR-ELISA for the molecular diagnosis of schistosomiasis mansoni. On following, PCR-ELISA platform laboratorial was evaluated in 206 feces samples collected of individual living in a Brazilian low endemicity area. RESULTS: The PCR-ELISA laboratorial platform indicated a prevalence rate of 25.2%, which was higher than the Kato-Katz technique (18.4%) and lower than the commercial platform (30...
July 11, 2018: BMC Research Notes
Anne Herrmann, Rob Sanson-Fisher, Alix Hall, Laura Wall, Nicholas Zdenkowski, Amy Waller
OBJECTIVE: Cancer patients and their support persons commonly feel overwhelmed when being confronted with their diagnosis and treatment options. We used a DCE to examine patients' and support persons' preferences for: (i) attending one 40 min consultation or two 20 min consultations when making a cancer treatment decision; and for (ii) receiving additional information in written form only or in both written and online forms. Here we focus on support persons' preferences and whether they differ from patients' preferences...
July 11, 2018: BMC Research Notes
Marie Cariou, Céline Ribière, Stéphanie Morlière, Jean-Pierre Gauthier, Jean-Christophe Simon, Pierre Peyret, Sylvain Charlat
OBJECTIVE: Targeted sequencing of 16S rDNA amplicons is routinely used for microbial community profiling but this method suffers several limitations such as bias affinity of universal primers and short read size. Gene capture by hybridization represents a promising alternative. Here we used a metagenomic extract from the pea aphid Acyrthosiphon pisum to compare the performances of two widely used PCR primer pairs with DNA capture, based on solution hybrid selection. RESULTS: All methods produced an exhaustive description of the 8 bacterial taxa known to be present in this sample...
July 11, 2018: BMC Research Notes
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