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Recent Patents on Drug Delivery & Formulation

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https://www.readbyqxmd.com/read/29611489/nanocarriers-for-the-effective-treatment-of-cervical-cancer-research-advancements-and-patent-analysis
#1
Nida Akhtar, Kamla Pathak
BACKGROUND: Cervical cancer being the cancer of cervix is caused by the aberrant cell growth that acquires an ability to spread/ invade to other body parts as well. It has been reported to be the second most commonest cause of death and cancer as well among women. Based on the severity of the disease, treatment aspect needs to be explored more in order to overcome the limitations acquired by conventional treatment. Recently, nanocarriers based drug delivery systems including liposomes, nanofibres, metallic NPs, polymeric NPs, dendrimers, polymeric micelles, antibody-drug conjugates etc...
April 2, 2018: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29521255/an-overview-on-various-approaches-and-recent-patents-on-gastroretentive-drug-delivery-systems
#2
Manoj Kumar, Deepak Kaushik
Drugs having absorption window in the stomach or upper small intestine has restricted bioavailability with conventional dosage forms. The gastric residence time of these dosage forms is usually short and they do not show drug release for prolonged period of time. To avoid these problems and to enhance the bioavailability and gastric retention time of these drugs, controlled drug delivery systems with prolonged gastric retention time are currently being developed. This review highlights the various pharmaceutical approaches for gastroretention such as floating drug delivery systems, mucoadhesive systems, high density systems, expandable and swelling systems, superporous hydrogels systems, magnetic systems, ion exchange resin system and recent patents filed or granted for these approaches...
March 8, 2018: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29485013/development-of-microemulsion-based-nabumetone-transdermal-delivery-for-treatment-of-arthritis
#3
Swati Jagdale, Gokul Deore, Anuruddha Chabukswar
Background Nabumetone is biopharmaceutics classification system (BCS) class II drug, widely used in the treatment of osteoarthritis and rheumatoid arthritis. The most frequently reported adverse reactions for the drug involve disturbance in gastrointestinal tract , diarrhea, dyspepsia and abdominal pain. Microemulgel has advantages of microemulsion for improving solubility for hydrophobic drug. Patent literature had shown that the work for drug has been carried on spray chilling, enteric coated tablet, and topical formulation which gave idea for present research work for development of transdermal delivery...
February 26, 2018: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29437029/formulation-and-in-vitro-and-ex-vivo-evaluation-of-tretinoin-loaded-cubosomal-gel-for-acne-treatment
#4
Gaurav Gupta, Shruti Sureka
OBJECTIVE: The current work was attempted to formulate and evaluate the topical sustained release delivery systems potential of bicontinuous cubic monoglyceride -water phases - 'cubosomes' containing Tretinoin with an opinion to sustain the release of drug in the acne treatment. METHODS: Tretinoin loaded cubosomes were prepared by bottom-up technique, by varying the concentration of lipid and surfactant and keeping the drug concentration constant, made a total of nine formulations of tretinoin as TCF...
February 13, 2018: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29359680/withdrawn-novel-ternary-polymeric-blends-for-controlled-release-matrices-containing-weakly-basic-model-drug
#5
(no author information available yet)
No abstract text is available yet for this article.
January 23, 2018: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29345599/crystalline-ethylene-oxide-and-propylene-oxide-triblock-copolymer-solid-dispersion-enhance-solubility-stability-and-promoting-time-controllable-release-of-curcumin
#6
Thais Francine Ribeiro Alves, Franciely Lopes, Marcia Rebelo, Juliana Souza, Katiusca Pontes, Carolina Santos, Patricia Severino, Jose Junior, Daniel Komatsu, Marco Vinicius Chaud
AIMS AND BACKGROUND: The design and development of an effective medicine are however often faced with a number of challenges. One of them is the close relationship of drug's bioavailability with solubility, dissolution rate and permeability. The use of curcumin's (CUR) therapeutic potential is limited by its poor water solubility and low chemical stability. The purpose was to evaluate the effect of polymer and solid dispersion (SD) preparation techniques to enhance the aqueous solubility, dissolution rate and stability of the CUR...
January 17, 2018: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29303083/patented-and-approval-scenario-of-nanopharmaceuticals-with-relevancy-to-biomedical-application-manufacturing-procedure-and-safety-aspects
#7
Vijay Agarwal, Meenakshi Bajpai, Ashish Sharma
A term 'nanopharmaceuticals' give the emphasis on the discovery, development and delivery of the drugs to the specific site using different delivery systems. Nanopharmaceutical field is a thrust area in which the development is going on progressively but the many new challenges are also arises continuously, such as regulatory requirements, identification of therapeutic targets, cost-effective and efficient tools for delivering the drug, standardization of different characterization method, etc. Some products related to this area that can be consistently and reproducibly prepared with a desired quality and is safe for the public, has been approved by the different regulatory agencies...
January 4, 2018: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29303082/aripiprazole-loaded-polymeric-micelles-fabrication-optimization-and-evaluation-using-response-surface-method
#8
Payal Hasmukhlal Patil, Pooja R Wankhede, H S Mahajan, Laxmikant Zawar
AIMS AND BACKGROUND: The fundamental objective of current study was to encapsulate Ari-piprazole (ARP) within Pluronic F127 micelles to improve its aqueous solubility. The recent patents on Ar-ipiprazole (JP2013136621) and micelles (WO2016004369A1) facilitated selection of drug and polymer. MATERIALS AND METHODS: The drug-laden micelles were fabricated using thin-film hydration technique. Optimization of the micellar formulation was done by using response surface method (RSM)...
January 4, 2018: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29303081/a-new-approach-to-enhance-the-solubility-of-famotidine-tablet-by-using-naturally-isolated-pear-starch
#9
Anjali Kushwaha, Manjul Pratap Singh
PURPOSE- The solubility of drug is affected by various excipients presents in formulation. In case of tablets the role of binders is very important for solubility of dosage form as well as drug. Thus in following study an attempt is made to improve the solubility and dissolution rate of a drug by use of natural excipients. The starch was extracted from the Pear fruits and used as a binder in different concentrations, in famotidine tablets and evaluate them. There are some recent patents on modified starch (WO2011002730A1), directly compressed starch (US6455069B1), pre-compacted starches (US4072535A), which helped in my study...
January 4, 2018: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29237390/chronopharmacokinetic-evaluation-of-budesonide-multiparticulate-systems
#10
Sowjanya Battu, Prasanna Raju Yalavarthi, G V Subbareddy, Uma Maheswara Rao, Jyothshna Devi Katamreddy, Harini Cowdary Vadlamudi
Poor oral absorption of budesonide limits design of its solid oral dosage form. With this context, multiparticulate pulsatile system of budesonide for chronotherapy of nocturnal asthma was aimed in this study. Initially, solid dispersions of budesonide (BD) using sodium starch glycolate (SSG) and guar gum (GG) were developed and characterized. Uniform sized non-pariel seeds (~400 µm) were coated with solid dispersions to obtain immediate (BMP) and controlled release pellets by solution layering technique. Pulsatile drug release pellets (BMPP) were obtained by coating the controlled release pellets with Eudragit L100 and RS 100...
December 12, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29219064/natural-product-formulations-for-prevention-and-treatment-of-alzheimer-s-disease-a-patent-review
#11
Rumiana Koynova, Boris Tenchov
INTRODUCTION: Although considerable efforts have been made to develop effective therapeutic agents for Alzheimer's disease (AD), neither a consensus concerning the pathogenesis of the disease nor a successful therapy for its treatment is available. The natural product chemistry brings tremendous diversity and abundant resource for medical needs. OBJECTIVES: The present review summarizes recent patents on natural extracts and derived drugs as agents for prevention and treatment of AD...
December 7, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29189187/thymoquinone-tq-a-potential-therapeutic-molecule-role-of-colloidal-carriers-in-its-effective-delivery
#12
Poonam Negi, Charul Rathore, Gajanand Sharma, Bhupinder Singh Bhoop, Om Prakash Katare
From the past few decades, remarkable awareness has been laid on the use of herbal medicines in pharmaceutical research. Thymoquinone (TQ), the main chemical constituent of Nigella sativa (NS) plant has been extensively explored and revealed an array of therapeutic benefits in different in vitro and in vivo conditions. This review provides brief outline of the diverse therapeutics actions of TQ and NS viz. anti-oxidant, anti-inflammatory, anti-cancer, anti-diabetic, gastro-protective, hepato-protective, anti-microbial and anti-histaminic...
November 29, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29189186/furosemide-soluplus%C3%A2-solid-dispersion-development-and-characterization
#13
Rammani Patwa, R Praveen, Sandeep Kumar Singh, Priya Ranjan Prasad Verma
Recent patents reveal that Soluplus® has proved to be a promising excipient that modulates dissolution characteristics of many active pharmaceutical ingredients (WO 2016161995 A1, WO 2016169534 A1, WO 2016165676 A1). Current article investigate on stable solid solution of furosemide with Soluplus to enhance the dissolution properties of the drug. Drug:carrier ratios to prepare solid dispersion was selected based on the phase solubility study. Solid dispersions of furosemide with Soluplus® were prepared by solvent evaporation and fusion method...
November 29, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29189185/enhanced-both-in-vitro-and-in-vivo-kinetics-by-slns-induced-transdermal-system-of-furosemide-a-novel-approach
#14
Revathi Mannam, Indira Muzib Yallamalli
AIM AND BACKGROUND: Furosemide is a potent diuretic agent used to treat pulmonary arterial hypertension. Variable dosage regimen and poor pharmacokinetic parameters has led to the development of transdermal drug delivery system. A patent on suitability of multi-lamellar structures for excellent transdermal delivery (US 0367475A1) has encouraged us to formulate the solid lipid nanoparticles (SLNs) induced transdermal systems of furosemide to enhance the kinetic properties without incorporating any penetration enhancer and rate limiting polymers...
November 28, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29165100/phytochemicals-formulated-as-nanoparticles-inventions-recent-patents-and-future-prospects
#15
Namdeo Jadhav, Sameer Nadaf, Dipali Lohar, Pravin Ghagare, Trupti Powar
BACKGROUND: The quest to improve the therapeutic effectiveness of herbal drugs has driven rigorously the pharmaceutical research towards development of herbal nanoparticles. Till date, various approaches have been adopted for the design of herbal nanoparticles. METHODS: We carried out an organized search of bibliographic databases consisting of an ample number of published abstracts and research articles using a focused review questionaries and insertion/omission criteria...
November 19, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29119940/development-of-floating-delivery-for-solid-self-micro-emulsifying-drug-delivery-system-of-prochlorperazine-maleate
#16
Swati Jagdale, Mayuri Shinde
Background Prochlorperazine maleate(PCM) is a phenothiazine antipsychotic used in the treatment of nausea, vomiting and vertigo. It is BCS class II drug with only 12.5% bioavailability. Patents data on PCM had shown work on conjugation and matrix formulation which suggested idea for the present work design. Objective The objective of this study was to enhance solubility of drug and to optimize gastro retentive floating capsule for controlled drug release at the targeted site for stipulated time. Method The solubility of drug was determined in various vehicles like oils, surfactants and co-surfactants...
November 7, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29032765/recent-patent-advances-for-neurodegenerative-disorders-and-its-treatment
#17
Bhavna Kumar, Deepika Sharma
BACKGROUND: Neurodegenerative disorders are one of the common diseases that affect our society with tremendous medical and financial burdens. As a whole, neurodegeneration affects individuals of all ages, but becomes increasingly frequent with age, coming to affect a very large share of our elderly population which is severely affecting the patient, caregivers, and enormously increasing the financial burden of the nation. These diseases share a very complex nature, which often result from combined genetic, environment and pathogenic factors...
October 10, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29332561/editorial
#18
EDITORIAL
Ryan F Donnelly
No abstract text is available yet for this article.
2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/28901845/a-review-of-patents-on-therapeutic-potential-and-delivery-of-hydroge-n-sulfide
#19
Richa Verma, Yumna Akhtar, Somnath Singh
BACKGROUND: Hydrogen sulfide (H2S) is a colorless gas with a characteristic smell of rotten eggs. Once only thought of as a toxic gas, evidence now shows that H2S plays major roles in pathological and physiological activities. These roles are being utilized to treat diseases and disorders ranging from hypertension, inflammation, edema, cardiovascular issues, chronic pain, cancer, and many more. Challenges facing the use of H2S currently involve achieving the optimum therapeutic concentrations, synthesizing chemically and physiologically stable donors, and developing clinically appropriate delivery systems...
2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/28877660/editorial
#20
EDITORIAL
Ryan F Donnelly
No abstract text is available yet for this article.
2017: Recent Patents on Drug Delivery & Formulation
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