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Recent Patents on Drug Delivery & Formulation

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https://www.readbyqxmd.com/read/28294074/probiotics-as-a-tool-to-biosynthesize-metallic-nanoparticles-research-reports-and-patents-survey
#1
Nida Ahktar, Kamla Pathak
BACKGROUND: Probiotics are the live microbes that exert beneficial effects on the health of the host cell and thus creating novel nanoformulations via probiotic bacteria have gained tremendous momentum recently. The probiotic bacteria are being employed in synthesizing or more specifically biosynthesizing several nanoparticles like metallic as well as non-metallic nanoparticles. Biosynthesis of metallic nanoparticles is currently focused of research nowadays due to several applications thereof...
March 13, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/28201962/preparation-and-optimization-of-fast-dissolving-film-of-naratriptan-hydrochloride
#2
Krishna D Koradia, Pradip T Sidhdhapara, Navin R Sheth
BACKGROUND AND OBJECTIVE: Naratriptan is second-generation triptan class of antimigraine drug which selectively bind with 5-HT(1B/1D) receptor. It is widely used to treat the migraine attack due to its better tolerability and lower recurrence rate as compared to other triptans. Despite of the applicability, Naratriptan also have several drawback like slow onset of action and fist pass metabolism which reduce its efficacy. In order to increase the efficacy of naratriptan fast dissolving film is prepared...
February 12, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/28201961/development-and-characterization-pulsatile-microspheres-of-nifedipine-for-hypertension
#3
Rahul Taneja, Ghanshyam Das Gupta
AIM AND BACKGROUND: To develop pulsatile microspheres of Nifedipine blend of polymers Carbopol 971P and Eudragit RS100 for antihypertensive to release the drug at a particular lag time. METHODS: Pulsatile nifedipine microspheres were prepared using blend of Carbopol 971P and Eudragit RS100 at different ratio in a mixture of solvents. Formulations were prepared and optimized on the basis of particle size, percentage yield and drug entrapment efficiency. Optimized formulations were further analyzed at different resolutions per minute (rpm) by optical microscopy, scanning electron microscopy (SEM), in-vitro dissolution studies and kinetics model...
February 12, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/28103774/formulation-development-and-evaluation-of-lyophilized-nasal-inserts-for-migraine-treatment
#4
Atishkumar Mundada, Harshada Sarode
BACKGROUND: Nasal inserts are novel, solid, bioadhesive dosage forms administered via nasal route for prolonged systemic drug delivery. The principle of the dosage form is that, after administration nasal inserts imbibe nasal fluid from the mucosa and form a gel in the nasal cavity in order to avoid foreign body sensation. The objective of this investigation was the development of chitosan/xanthan gum based bioadhesive nasal inserts of antimigraine drug. METHODS: Lyophilization is more usual technique for the preparation of nasal inserts and it is one of the applied methods for drying of solids either in the form of aqueous solution or rarely in the form of aqueous suspension by using freeze dryers...
January 18, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/28124592/acyclovir-solid-lipid-nanoparticles-for-skin-drug-delivery-fabrication-characterization-and-in-vitro-study
#5
Maria John Newton, Kaur Bhupinder
OBJECTIVE: The fractionated coconut oil based solid lipid nanoparticles (SLNs) of Acyclovir (ACV) were fabricated in two batches by using Glyceryl mono stearate (GMS) and Lipoid S75 (Fat free soybean phospholipids with 70% phosphatidylcholine- Lipoid GmbH, Germany). The research was focused on developing ACV-SLN by using high pressure hot-homogenization technique. The ingredients were used in different concentrations and ratios to identify the best formulation design. METHODS: The GMS with Fractionated coconut oil and Lipoid S 75 with Fractionated coconut oil were used in various concentrations in formulation design to assess the impact on the fabrication and evaluation of SLNs...
January 17, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/28088896/formulation-and-optimization-of-lansoprazole-pellets-using-factorial-design-prepared-by-extrusion-spheronization-technique-using-carboxymethyl-tamarind-kernel-powder
#6
Sagar Sopanrao Muley, Tanaji Nandgude, Sushilkumar Poddar
BACKGROUND: In the present study, Lansoprazole pellets were prepared employing a novel excipient Carboxymethyl tamarind kernel powder (CMTKP) using extrusion-spheronization technique. Pellet formulation was optimized for formulation parameters (concentration of microcrystalline cellulose, CMTKP, croscarmellose sodium and isopropyl alcohol). METHODS: Process parameters (speed and duration of spheronization) were optimized using factorial design. The pellets were evaluated for yield, bulk and tapped density, particle size, hardness, drug content, disintegration time and drug release...
January 13, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/28056749/development-and-evaluation-of-naproxen-sodium-gel-using-piper-cubeba-for-enhanced-transdermal-drug-delivery-and-therapeutic-facilitation
#7
Sunetra Kaustubh Patwardhan, Manohar J Patil, Anbazhagan Sockalingam
BACKGROUND: The absorption of drug through skin avoids many side effects of oral route like gastric irritation, nausea, systemic toxicity etc and thus improves patient compliance. Naproxen sodium (NPRS) is one of the potent NSAID agents. OBJECTIVE: The present study was aimed to develop and evaluate the gel formulation containing NPRS for transdermal drug delivery reducing the side effects and improving patient compliance. The patents on topical delivery of NSAIDS (US 9012402 B1, US 9072659 B2, US 20150258196 A1) and patents indicating use of herbal penetration enhancers (US 20100273746A1, WO 2005009510 A2, US 6004969 A) helped in selecting the drug, excipients...
January 5, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/27993107/anti-psychotic-activity-of-aqueous-root-extract-of-hemidesmus-indicus-a-time-bound-study-in-rats
#8
Madhu Sudan, Gaurav Gupta, Bharati Arali, Dinesh Kumar Chellappan, Kamal Dua
AIMS AND BACKGROUND: Psychosis is a neurological disorder which is usually defined as "loss of contact with reality." As medicine 'Hemidesmusindicus' hold a reputed place in all systems of medicine in India. It is given in the form of infusion, fine particles, or syrup. It is also a component of several medicinal preparations. The present research work is pertaining to find out an anti-psychotic activity of an aqueous root extract of Hemidesmusindicus- a time bound study in rats. METHODS: In the present study, the dried roots of Hemidesmusindicus were crushed to a coarse powder and extracted with water under reflux for 36 hours to obtain the aqueous extract of roots of Hemidesmusindicus (AERHI)...
December 16, 2016: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/27855615/addressing-the-challenge-of-developing-a-physiologically-relevant-dissolution-test-for-regulatory-purposes
#9
Vivian Gray
The challenge of developing a physiologically relevant dissolution test to satisfy regulatory agencies has pushed drug manufacturers to engage in "design of experiment" method development, which helps manufacturers address variability, dissolution medium, and surfactant use-all of which will influence dissolution.
November 17, 2016: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/27809755/multi-particulate-systems-cutting-edge-technology-for-controlled-drug-delivery
#10
Sarika Wairkar, Ram Gaud, Adhithi Raghavan
BACKGROUND: In the last two decades, multi-particulate dosage forms have caught the attention of formulation scientists due to their tremendous potential as a drug delivery system with a broad range of applications. METHODS: Recent patented technologies are focused on designing multi-particulate systems that can enhance therapeutic efficacy and oral bioavailability with minimum systemic toxicity. The technologies offer opportunities to the manufacturers for increasing their market share, especially for competitive generics, and also establishing intellectual property positions...
November 3, 2016: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/27774911/self-emulsifying-pellets-prepared-by-extrusion-spheronization-in-vitro-in-vivo-evaluation
#11
Md Akhlaquer Rahman, Md Mujahid, Arshad Hussain
AIMS: The purpose of the current study was to investigate the feasibility of producing solid self-emulsifying pellets using the extrusion/spheronization technique with an aim to increase the bioavailability of selected drug and also to encounter the problems associated with liquid lipid formulations. Self-emulsifying formulations are experiencing a very active development as reflected by the numerous publications and patents being granted on these systems. The patents on self-emulsifying formulation (US20036630150) and (US20006054136) helped in selecting the drug and excipients...
October 21, 2016: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/27774912/development-of-self-emulsifying-formulations-of-poorly-soluble-naproxen-for-enhanced-drug-delivery
#12
Subhash Chandra Bose Penjuri, Saritha Damineni, Nagaraju Ravouru, Srikanth Reddy Poreddy Reddy Poreddy
BACKGROUND: The objective of this investigation was to develop a self emulsifying drug delivery system (SEDDS) of naproxen, a poorly water soluble drug, which could improve its solubility and oral bioavailability. Methoda: The recent patents on SEDDS of abiraterone acetate (WO2014/009434 A1) and tamoxifen (WO2013/0080083) helped in selecting the naproxen and excipients. Phase diagrams were constructed and the formulations were taken from the micro emulsion region. Formulations were subjected to thermodynamic stability, dispersibility and precipitation tests for optimization...
October 19, 2016: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/27712569/liposomal-drug-delivery-system-for-cancer-therapy-advancement-and-patents
#13
Sheetal Jha, Pramod Sharma, Rishabha Malviya
In this review article, authors reviewed about the liposomes which are amongst various drug delivering systems for the delivery of the therapeutic agents at the target site. Advances in liposomal drug delivery systems for the cancer therapy have enhanced the therapeutic levels of the anticancer moieties. Liposomes show promising action on the tumor by incorporating less amount of drug at the target site, with minimum toxic effect and maximum therapeutic effect and thereby enhancing the bioavailability. Liposome- based drug delivery systems provide the potential to elevate the effect of drug concentration in tumour cells...
October 4, 2016: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/27712568/formulation-development-and-optimization-of-matrix-tablet-of-tramadol-hydrochloride
#14
Pulak Deb, Jubaraj Singha, Indranil Chanda, Prithviraj Chakraborty
AIM AND BACKGROUND: The aim of the present investigation is to formulate and optimize oral sustained release matrix tablet of highly water soluble drug Tramadol HCl and to evaluate the effect of varying concentration of hydrophilic and hydrophobic polymer on drug release, based on a survey done on the recent patents of Tramadol HCl (US7374781, CA 2479252) and sustained release matrix tablets. MATERIALS AND METHODS: The tablets were prepared by double granulation process, by melt granulation and wet granulation technique using Carnauba wax(CW) and HPMC K100 as release retardant ...
October 4, 2016: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/27712567/development-and-optimization-of-controlled-porosity-osmotic-tablets-of-lamotrigine-solid-dispersion
#15
Gayatri C Patel, Megha Kasarwala
BACKGROUND: The purpose of this study was to investigate the application of a controlled porosity osmotic tablet (CPOT) utilizing solid dispersion (SD) of poorly soluble drug. The patents on Cyclobenzaprine HCl (US4968507 A) and Venlafaxine salts (EP 2085078 A1) helped in selection of drug and polymers. METHOD: The SDs having different ratio of drug to carrier (PVP K 30) were prepared by kneading method and optimized. Effect of three independent variables, total amount of osmogen (mannitol& potassium chloride), total amount of polymer (polyethylene oxide WSR 301, hydroxy propyl methyl cellulose K100 M), and polymer1: polymer 2 ratio was investigated using Box Behnken design...
October 4, 2016: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/27456458/impact-of-pluronic-f-68-vs-tween-80-on-fabrication-and-evaluation-of-acyclovir-slns-for-skin-delivery
#16
Maria John Newton, Bhupinder Kaur
The solid lipid nanoparticles (SLNs) of Acyclovir (ACV) were fabricated with Soya lecithin and Fractionated Coconut oil (medium chain glyceride) as a first time combination. The research was focused on developing ACV-SLN by using high pressure hot-homogenization technique. The ingredients were used in different concentrations and ratios to identify the best formulation design. The tween 80 and Pluronic F-68 were used in various concentrations in formulation design to assess the impact on the fabrication and evaluation of SLNs...
July 24, 2016: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/27396400/quality-by-design-qbd-approach-for-development-of-co-processed-excipient-pellets-momlets-by-extrusion-spheronization-technique
#17
Hetal Patel, Kishan Patel, Sanjay Tiwari, Sonia Pandey, Mukesh Gohel
BACKGROUND: Microcrystalline cellulose (MCC) is an excellent excipient for production of pellets by extrusion spheronization. However, it causes slow release rate of poorly water soluble drugs from pellets. Co-processed excipient prepared by spray drying (US 4,744,987; US 5686107; WO 2003/051338) and co-precipitation technique (WO 95/17831) are patented. OBJECTIVE: The objective of present study was to develop co-processed MCC pellets (MOMLETS) by extrusion-spheronization technique using the principle of Quality by Design (QbD)...
July 9, 2016: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/27398423/preface
#18
Ryan F Donnelly
No abstract text is available yet for this article.
2016: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/26996367/pharmacological-effect-of-berberine-chloride-in-propyl-thiouracil-induced-thyroidal-dysfunction-a-time-bound-study-in-female-rats
#19
Harikesh Maurya, Sheena Dhiman, Kamal Dua, Gaurav Gupta
BACKGROUND: The present study is aimed at bringing out the information on the effect of berberine chloride in hyper and hypo thyroidal model with two dose levels. OBJECTIVE: The research article also reviewed details of various existing patents associated with comprehensive compilation regarding the therapeutic application of berberine and related forms. METHOD: Sixty female wistar rats weighing between 150-250 gm were divided in to 10 groups...
2016: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/26996366/nanosized-drug-delivery-systems-for-direct-nose-to-brain-targeting-a-review
#20
REVIEW
Kunjan Phukan, Marika Nandy, Rupanjali B Sharma, Hemanta K Sharma
BACKGROUND: Drug targeting to brain has always been problematic due to Blood-Brain Barrier (BBB), which, does not allow most of the drugs to pass through it as they are hydrophilic and macromolecular drugs. So, in order to bypass the BBB, alternative modes of administration were searched and nasal to brain delivery route was tried by many workers. Such studies yielded patented nano-formulations with the ability to cross blood brain barrier. METHODS: Nanoparticles being smaller in size and large surface area help in increasing the rate of drug permeation to the brain...
2016: Recent Patents on Drug Delivery & Formulation
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