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Recent Patents on Drug Delivery & Formulation

Vivian Gray
The challenge of developing a physiologically relevant dissolution test to satisfy regulatory agencies has pushed drug manufacturers to engage in "design of experiment" method development, which helps manufacturers address variability, dissolution medium, and surfactant use-all of which will influence dissolution.
November 17, 2016: Recent Patents on Drug Delivery & Formulation
Sarika Wairkar, Ram Gaud, Adhithi Raghavan
BACKGROUND: In the last two decades, multi-particulate dosage forms have caught the attention of formulation scientists due to their tremendous potential as a drug delivery system with a broad range of applications. METHODS: Recent patented technologies are focused on designing multi-particulate systems that can enhance therapeutic efficacy and oral bioavailability with minimum systemic toxicity. The technologies offer opportunities to the manufacturers for increasing their market share, especially for competitive generics, and also establishing intellectual property positions...
November 3, 2016: Recent Patents on Drug Delivery & Formulation
Md Akhlaquer Rahman, Md Mujahid, Arshad Hussain
AIMS: The purpose of the current study was to investigate the feasibility of producing solid self-emulsifying pellets using the extrusion/spheronization technique with an aim to increase the bioavailability of selected drug and also to encounter the problems associated with liquid lipid formulations. Self-emulsifying formulations are experiencing a very active development as reflected by the numerous publications and patents being granted on these systems. The patents on self-emulsifying formulation (US20036630150) and (US20006054136) helped in selecting the drug and excipients...
October 21, 2016: Recent Patents on Drug Delivery & Formulation
Subhash Chandra Bose Penjuri, Saritha Damineni, Nagaraju Ravouru, Srikanth Reddy Poreddy Reddy Poreddy
BACKGROUND: The objective of this investigation was to develop a self emulsifying drug delivery system (SEDDS) of naproxen, a poorly water soluble drug, which could improve its solubility and oral bioavailability. Methoda: The recent patents on SEDDS of abiraterone acetate (WO2014/009434 A1) and tamoxifen (WO2013/0080083) helped in selecting the naproxen and excipients. Phase diagrams were constructed and the formulations were taken from the micro emulsion region. Formulations were subjected to thermodynamic stability, dispersibility and precipitation tests for optimization...
October 19, 2016: Recent Patents on Drug Delivery & Formulation
Sheetal Jha, Pramod Sharma, Rishabha Malviya
In this review article, authors reviewed about the liposomes which are amongst various drug delivering systems for the delivery of the therapeutic agents at the target site. Advances in liposomal drug delivery systems for the cancer therapy have enhanced the therapeutic levels of the anticancer moieties. Liposomes show promising action on the tumor by incorporating less amount of drug at the target site, with minimum toxic effect and maximum therapeutic effect and thereby enhancing the bioavailability. Liposome- based drug delivery systems provide the potential to elevate the effect of drug concentration in tumour cells...
October 4, 2016: Recent Patents on Drug Delivery & Formulation
Pulak Deb, Jubaraj Singha, Indranil Chanda, Prithviraj Chakraborty
AIM AND BACKGROUND: The aim of the present investigation is to formulate and optimize oral sustained release matrix tablet of highly water soluble drug Tramadol HCl and to evaluate the effect of varying concentration of hydrophilic and hydrophobic polymer on drug release, based on a survey done on the recent patents of Tramadol HCl (US7374781, CA 2479252) and sustained release matrix tablets. MATERIALS AND METHODS: The tablets were prepared by double granulation process, by melt granulation and wet granulation technique using Carnauba wax(CW) and HPMC K100 as release retardant ...
October 4, 2016: Recent Patents on Drug Delivery & Formulation
Gayatri C Patel, Megha Kasarwala
BACKGROUND: The purpose of this study was to investigate the application of a controlled porosity osmotic tablet (CPOT) utilizing solid dispersion (SD) of poorly soluble drug. The patents on Cyclobenzaprine HCl (US4968507 A) and Venlafaxine salts (EP 2085078 A1) helped in selection of drug and polymers. METHOD: The SDs having different ratio of drug to carrier (PVP K 30) were prepared by kneading method and optimized. Effect of three independent variables, total amount of osmogen (mannitol& potassium chloride), total amount of polymer (polyethylene oxide WSR 301, hydroxy propyl methyl cellulose K100 M), and polymer1: polymer 2 ratio was investigated using Box Behnken design...
October 4, 2016: Recent Patents on Drug Delivery & Formulation
Maria John Newton, Bhupinder Kaur
The solid lipid nanoparticles (SLNs) of Acyclovir (ACV) were fabricated with Soya lecithin and Fractionated Coconut oil (medium chain glyceride) as a first time combination. The research was focused on developing ACV-SLN by using high pressure hot-homogenization technique. The ingredients were used in different concentrations and ratios to identify the best formulation design. The tween 80 and Pluronic F-68 were used in various concentrations in formulation design to assess the impact on the fabrication and evaluation of SLNs...
July 24, 2016: Recent Patents on Drug Delivery & Formulation
Hetal Patel, Kishan Patel, Sanjay Tiwari, Sonia Pandey, Mukesh Gohel
BACKGROUND: Microcrystalline cellulose (MCC) is an excellent excipient for production of pellets by extrusion spheronization. However, it causes slow release rate of poorly water soluble drugs from pellets. Co-processed excipient prepared by spray drying (US 4,744,987; US 5686107; WO 2003/051338) and co-precipitation technique (WO 95/17831) are patented. OBJECTIVE: The objective of present study was to develop co-processed MCC pellets (MOMLETS) by extrusion-spheronization technique using the principle of Quality by Design (QbD)...
July 9, 2016: Recent Patents on Drug Delivery & Formulation
Ryan F Donnelly
No abstract text is available yet for this article.
2016: Recent Patents on Drug Delivery & Formulation
Harikesh Maurya, Sheena Dhiman, Kamal Dua, Gaurav Gupta
BACKGROUND: The present study is aimed at bringing out the information on the effect of berberine chloride in hyper and hypo thyroidal model with two dose levels. OBJECTIVE: The research article also reviewed details of various existing patents associated with comprehensive compilation regarding the therapeutic application of berberine and related forms. METHOD: Sixty female wistar rats weighing between 150-250 gm were divided in to 10 groups...
2016: Recent Patents on Drug Delivery & Formulation
Kunjan Phukan, Marika Nandy, Rupanjali B Sharma, Hemanta K Sharma
BACKGROUND: Drug targeting to brain has always been problematic due to Blood-Brain Barrier (BBB), which, does not allow most of the drugs to pass through it as they are hydrophilic and macromolecular drugs. So, in order to bypass the BBB, alternative modes of administration were searched and nasal to brain delivery route was tried by many workers. Such studies yielded patented nano-formulations with the ability to cross blood brain barrier. METHODS: Nanoparticles being smaller in size and large surface area help in increasing the rate of drug permeation to the brain...
2016: Recent Patents on Drug Delivery & Formulation
Rohan Lalani, Ambikanandan Misra, Jitendra Amrutiya, Hinal Patel, Priyanka Bhatt, Sushil K Patil
BACKGROUND: The development and progression of atherosclerosis is known to occur at a sluggish pace and the lesions remain concealed for a long duration before the factual situation of the complex atherosclerotic etiology affecting various organ gets apprehended. The root cause mainly involves an imbalance or malfunction of the cholesterol metabolizing pathway. The till date therapeutic alternatives include oral hypo-lipidemic agents along with advances made in biotechnology/tissue engineering and surgical procedures for management purpose...
2016: Recent Patents on Drug Delivery & Formulation
Marcos L Bruschi, Raphaela R de A Pereira, Lizziane M B de Francisco
BACKGROUND: Propolis is a resinous material with complex chemical structure, produced by bees using plant sources, displaying a wide spectrum of biological activities. METHODS: Many studies have reported the use of this compound in pharmaceutical, medicinal, veterinary and dentistry areas, and the results have reported its pharmacological activities. RESULTS: Moreover, many propolis delivery systems have been proposed and evaluated, indicating that they can be used...
2016: Recent Patents on Drug Delivery & Formulation
Dinesh K Chellappan, Sivamalar Ganasen, Shaminiswary Batumalai, Mayuren Candasamy, Purushotham Krishnappa, Kamal Dua, Jestin Chellian, Gaurav Gupta
Natural antioxidant products are increasingly being used to treat various pathological liver injuries considering the role of oxidative stress in their pathogenesis. Auricularia polytricha has been used as food or medicine due to its antioxidant activity. The aim of the study was to evaluate the protective effect of the aqueous extract of the fruiting bodies of A. polytricha against paracetamol-induced liver toxicity in rats. Liver toxicity was induced in Sprague-Dawley rats by oral administration of 2g/kg paracetamol on the 15th day after the administration of aqueous extract and silymarin 100 mg/kg...
2016: Recent Patents on Drug Delivery & Formulation
Rajneet K Khurana, Mohit Mahajan, Teenu, Sonia Kapoor, Subheet Jain, Bhupinder Singh
Natural diterpenoid taxanes and their semisynthetic analogues have already made an indelible mark in the chemotherapeutic world for treating various kinds of malignancies. However, due to the absence of any functional groups which could be ionized by pH alteration or which may participate in salt formation, these taxanes, exhibit low solubility. Parenteral administration of taxanes with solubilising agents such as Cremophor EL and Polysorbate 80 results in undesirable side effects like hypersensitivity reactions, myelosuppression and peripheral neuropathy...
2016: Recent Patents on Drug Delivery & Formulation
Suryakanta Swain, Sarwar Beg, Sitty M Babu
Researchers are facing challenges to develop robust formulation and to enhance the bioavailability of poorly water-soluble drugs towards clinical applications. The development of new drug molecule alone is not adequate to assure ample pharmacotherapy of various diseases. Considerable results obtained from in vitro studies are not supported by in vivo data due to inadequate plasma drug concentrations. This may occur due to limited drug solubility and absorption. To resolve these problems, development of new drug delivery systems will be a promising approach...
2016: Recent Patents on Drug Delivery & Formulation
Mohammad Tariq, Anu T Singh, Zeenat Iqbal, Farhan J Ahmad, Sushama Talegaonkar
Typically, chemotherapy has been dominated by intravenous administration. Though, inclination towards oral ingestion of chemotherapeutics is increasing since it offers ample of fascinating opportunities including better quality of life, treatment advantages and low healthcare cost. However, low or moderate bioavailability along with significant inter-patient variability and narrow therapeutic window challenges their oral administration. Thus, optimization of oral route with maximized efficacy and miniminal adverse events is a challenging area...
2016: Recent Patents on Drug Delivery & Formulation
Animikh Ray, Abhirup Mandal, Mary Joseph, Ashim K Mitra
Cancer is a major malignancy which has claimed numerous lives worldwide. Despite huge resources being utilized to develop cancer therapeutics, no effective cure has been found so far. Hence there is a need to look at emerging technologies for a solution. Nanoparticle is one such technology that has become feasible and popular in the past few years. Though, it has not emerged as a drug delivery platform of choice for cancer therapeutics it has shown enormous promise. Different types of materials such as polymer, lipid, magnet, metal based nanoparticles have been developed to enhance the effectiveness of current treatment...
2016: Recent Patents on Drug Delivery & Formulation
Abolfazl Shakeri, Amirhossein Sahebkar
No abstract text is available yet for this article.
2016: Recent Patents on Drug Delivery & Formulation
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