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Recent Patents on Drug Delivery & Formulation

Pooja Jain, Nazia Hassan, Zeenat Iqbal, Fahima Dilnawaz
BACKGROUND: Nanotechnology based drug delivery approach has emerged as a promising field, where different kinds of formulations are developed for therapeutic applications. Inflowing of nanomedicine developed through various biomaterials appears to be a game changer in the domain of pharmaceutical and biotechnological industries. Nanomedicines propose to overcome the major constraints of conventional medicine of low solubility and stability, and non-adequate pharmacokinetic profiles and side effects...
December 3, 2018: Recent Patents on Drug Delivery & Formulation
Simpal Kumari, Vipan Kumar Kamboj, Diksha Rajpoot, Anil Teotia, Prabhakar Kumar Verma, Gyanendra Nath Singh
BACKGROUND: Gold nanoparticles possess unique mechanical, chemical, photo-optical and biological properties and have been an interesting field of research and development in life sciences. Research efforts in this area have resulted in innovative nanodevices and nanostructures useful in the diagnostics, biosensing, therapeutics, and targeted drug delivery. OBJECTIVE: In this review, the unique potential aspects of gold nanoparticles/ nanoformulations/ or devices related to diabetes management have been discussed together with the recent patent on the gold nanoparticles / or developed for diabetes management...
November 14, 2018: Recent Patents on Drug Delivery & Formulation
Madhu Verma, Arun Nanda, Yatendra Kumar
PURPOSE: The purpose of the study was formulation development, optimization and evaluation of a Self-Emulsifying Drug Delivery System (SEDDS) of Simvastatin (SIM) for improvement in dissolution and bioavailability of SIM. Solubility enhancement of Biopharmaceutical Classification System (BCS) Class-II drugs is a burning topic and attracting various publications and patents regarding different strategies employed for improvement of dissolution viz., USOO5340591A (Solid dispersion), US005472954A, US005646131A (complexation), USOO5858410A (Nanosuspensions), USOO5874029A (micronization) US 2008...
October 22, 2018: Recent Patents on Drug Delivery & Formulation
Dilpreet Singh, Ashok K Tiwary, Neena Bedi
OBJECTIVE: The aim of the present investigation entails the development of solid SMEDDS for improving the oral bioavailability of canagliflozin using porous carriers. The previous patent (WO2017046730A1) was based on enhanced of solubility of canagliflozin through co-crystal formation. METHODS: Preconcentrates were prepared by employing Lauroglycol (80 mg), Tween 80 (300 mg) and Transcutol P (120 mg) and successfully adsorbed onto various hydrophilic and hydrophobic carriers...
October 8, 2018: Recent Patents on Drug Delivery & Formulation
Poppy Das, Kiran Kumar, Arunai Nambiraj, Rajendra Awasthi, Kamal Dua, Himaja Malipeddi
BACKGROUND: Herbal drugs are gaining exponential scientific recognition due to their distinct advantages. In the last 2-3 decades, a gradual increase in worldwide patents on herbal nano-formulations has been noted to address the solubility and bioavailability issues of phytoceuticals. Struvite or ammonium magnesium phosphate hexahydrate (NH4MgPO4.6H2O) is among the important urinary infection stones causing painful urological ailment. These smaller stones may bind together to form a bigger staghorn calculi...
July 23, 2018: Recent Patents on Drug Delivery & Formulation
He Meng, Curtis Lockshin, Sanjay Jain, Umesh Shaligram, Joseph Martinez, Dmitry Genkin, David B Hill, Camille Ehre, Dana Clark, Henry Hoppe
While protein therapeutics are invaluable in managing numerous diseases, many require frequent injections to maintain therapeutically effective concentrations, due to their short half-life in circulation. PolyXenâ„¢, a platform technology employing biodegradable, non-immunogenic and hydrophilic polysialic acids (PSA) for drug delivery, is being utilized to overcome such limitations, thereby enabling the clinical utility of a broad range of protein therapeutics. Here, we report the recent progress on two development candidates, polysialylated erythropoietin (PSA-EPO) and polysialylated deoxyribonuclease I (PSA-DNase)...
July 17, 2018: Recent Patents on Drug Delivery & Formulation
Laxmikant R Zawar, Sanjay B Bari
AIM AND BACKGROUND: The objective of the study was to improve the bioavailability of poorly soluble repaglinide (RPG) by preparing nanosuspension with poloxamer 188 using high pressure homogenization (HPH). The recent patents on nanocrystals (US20150337006A1) facilitated selection of drug and polymer. METHODS: Suspensions containing dissimilar sized particles were prepared by ultrasonication and HPH. The prepared aqueous suspensions were lyophilized and then characterized...
July 12, 2018: Recent Patents on Drug Delivery & Formulation
Ashka Amina, Deepali V Kaduskar
AIMS AND BACKGROUND: Number of pathogenic microorganisms have been increasing over the years, and so as these microorganisms been developing resistance against various antibiotics. Antimicrobial photodynamic therapy (aPDT), also called photodynamic inactivation, is emerging as a promising alternative to treatments based on conventional antibiotics. Recent patents on structured silver mesoporous silica nanoparticles having antimicrobial activity (WO2010/071831 A2), photosensitiser modified core-shell structure nanocomposites (CN 103536935(A)), and Chitosan-coated magnetic mesoporous silica nanoparticles (CN 104785214(A)) helped in selecting method of synthesis of MSN and photosensitizers...
June 26, 2018: Recent Patents on Drug Delivery & Formulation
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No abstract text is available yet for this article.
January 23, 2018: Recent Patents on Drug Delivery & Formulation
Chaitrali Gijare, Ashwini Deshpande
BACKGROUND: Nowadays, Oral Film Technology (OFT) has gained much attention among all the oral drug delivery systems. Fast dissolving film, fast disintegrating film, and orodispersible film are some synonymous words for this dosage form. Without a need of liquid for administration, this dosage form dissolves in the mouth. Typically, fast dissolving film dissolves from 1 to 30 seconds. OBJECTIVE: At the root of its originality, many researchers patented their work on the aspect of orodispersible films using different drugs, polymers, excipients and employing various methods of preparation...
2018: Recent Patents on Drug Delivery & Formulation
Kamla Pathak, Nida Akhtar
BACKGROUND: Cervical cancer being the cancer of cervix is caused by an aberrant cell growth that acquires an ability to spread/ invade to other body parts. It has also been reported to be the second most common cause of death and cancer among women. Based on the severity of the disease, treatment aspects need to be explored more in order to overcome the limitations acquired by the conventional treatment. Recently, nanocarriers based drug delivery systems including liposomes, nanofibres, metallic NPs, polymeric NPs, dendrimers, polymeric micelles, antibody-drug conjugates, etc...
2018: Recent Patents on Drug Delivery & Formulation
Manoj Kumar, Deepak Kaushik
BACKGROUND: Drugs having absorption window in the stomach or upper small intestine have restricted bioavailability with conventional dosage forms. The gastric residence time of these dosage forms is usually short and they do not show drug release for prolonged period of time. OBJECTIVE: To avoid these problems and to enhance the bioavailability and gastric retention time of these drugs, controlled drug delivery systems with prolonged gastric retention time are currently being developed...
2018: Recent Patents on Drug Delivery & Formulation
Swati C Jagdale, Gokul K Deore, Anuruddha R Chabukswar
BACKGROUND: Nabumetone is biopharmaceutics classification system (BCS) class II drug, widely used in the treatment of osteoarthritis and rheumatoid arthritis. The most frequently reported adverse reactions for the drug involve disturbance in gastrointestinal tract, diarrhea, dyspepsia and abdominal pain. Microemulgel has advantages of microemulsion for improving solubility for hydrophobic drug. Patent literature had shown that the work for drug has been carried on spray chilling, enteric coated tablet, and topical formulation which gave an idea for present research work for the development of transdermal delivery...
2018: Recent Patents on Drug Delivery & Formulation
Shruti Sureka, Gaurav Gupta, Mohit Agarwal, Anurag Mishra, Santosh K Singh, Ravindra P Singh, Sushil K Sah, Terezinha de Jesus A Pinto, Kamal Dua
OBJECTIVE: The current work was attempted to formulate and evaluate the topical sustained release delivery systems called cubosomes containing Tretinoin for the acne treatment. The recent patents on various formulations of tretinoin (EP0408370A2) helped in selecting a new formulation and evaluation. METHODS: Tretinoin loaded cubosomes were prepared by bottom-up technique, using varying the concentration of lipid and surfactant and keeping the drug concentration constant, a total of nine formulations of tretinoin was developed...
2018: Recent Patents on Drug Delivery & Formulation
Thais F R Alves, Franciely C C das Neves Lopes, Marcia A Rebelo, Juliana F Souza, Katiusca da Silva Pontes, Carolina Santos, Patricia Severino, Jose M O Junior, Daniel Komatsu, Marco V Chaud
AIMS AND BACKGROUND: The design and development of an effective medicine are, however, often faced with a number of challenges. One of them is the close relationship of drug's bioavailability with solubility, dissolution rate and permeability. The use of curcumin's (CUR) therapeutic potential is limited by its poor water solubility and low chemical stability. The purpose was to evaluate the effect of polymer and solid dispersion (SD) preparation techniques to enhance the aqueous solubility, dissolution rate and stability of the CUR...
2018: Recent Patents on Drug Delivery & Formulation
Vijay Agarwal, Meenakshi Bajpai, Ashish Sharma
BACKGROUND: Nanopharmaceutical is the field that arises gradually but many challenges are also still there. This review aims to identify these challenges and give the focus on their rectification. METHODS: In this paper, we memorize the safety issues, patented manufacturing procedure, applications and regulatory aspects of the nanopharmaceuticals by using the peer-reviewed research literatures. All the screened literatures described the quality content of nanopharmaceuticals with relevancy to biomedical and pharmaceutical field...
2018: Recent Patents on Drug Delivery & Formulation
Payal H Patil, Pooja R Wankhede, Hitendra S Mahajan, Laxmikant R Zawar
AIMS AND BACKGROUND: The fundamental objective of current study was to encapsulate Aripiprazole (ARP) within Pluronic F127 micelles to improve its aqueous solubility. The recent patents on Aripiprazole (JP2013136621) and micelles (WO2016004369A1) facilitated selection of drug and polymer. MATERIALS AND METHODS: The drug-laden micelles were fabricated using thin-film hydration technique. Optimization of the micellar formulation was done by using response surface method (RSM)...
2018: Recent Patents on Drug Delivery & Formulation
Kushwaha Anjali, Singh P Manjul
PURPOSE: The solubility of drug is affected by various excipients present in formulation. In case of tablet formulation, the role of binders is very important for solubility of dosage form as well as drug. In this study, an attempt was made to improve the solubility and dissolution rate of a drug by the use of natural excipients. In this study, pear was selected for the extraction and isolation of starch. Then the extracted starch was used as a binder in different concentrations, in famotidine tablets and evaluates them...
2018: Recent Patents on Drug Delivery & Formulation
Rumiana Koynova, Boris Tenchov
INTRODUCTION: Although considerable efforts have been made to develop effective therapeutic agents for Alzheimer's Disease (AD), neither a consensus concerning the pathogenesis of the disease nor a successful therapy for its treatment is yet available. The natural product chemistry brings tremendous diversity and abundant resource for medical needs. OBJECTIVES: The present review summarizes recent patents on natural extracts and derived drugs as agents for the prevention and treatment of AD...
2018: Recent Patents on Drug Delivery & Formulation
Poonam Negi, Charul Rathore, Gajanand Sharma, Bhupinder Singh, Om P Katare
BACKGROUND: From the past few decades, remarkable awareness has laid on the use of herbal medicines in pharmaceutical research. Thymoquinone (TQ), the main chemical constituent of Nigella Sativa (NS) plant, has been extensively explored, and revealed an array of therapeutic benefits, in different in vitro, and in vivo conditions. This review provides brief outline of the diverse therapeutics actions of TQ, and NS, viz. anti-oxidant, anti-inflammatory, anti-cancer, anti-diabetic, gastroprotective, hepato-protective, anti-microbial and anti-histaminic...
2018: Recent Patents on Drug Delivery & Formulation
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