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Autism Research: Official Journal of the International Society for Autism Research

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https://www.readbyqxmd.com/read/30638310/how-effective-is-lena-in-detecting-speech-vocalizations-and-language-produced-by-children-and-adolescents-with-asd-in-different-contexts
#1
Rebecca M Jones, Daniela Plesa Skwerer, Rahul Pawar, Amarelle Hamo, Caroline Carberry, Eliana L Ajodan, Desmond Caulley, Melanie R Silverman, Shannon McAdoo, Steven Meyer, Anne Yoder, Mark Clements, Catherine Lord, Helen Tager-Flusberg
The LENA system was designed and validated to provide information about the language environment in children 0 to 4 years of age and its use has been expanded to populations with a number of communication profiles. Its utility in children 5 years of age and older is not yet known. The present study used acoustic data from two samples of children with autism spectrum disorders (ASD) to evaluate the reliability of LENA automated analyses for detecting speech utterances in older, school age children, and adolescents with ASD, in clinic and home environments...
January 14, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/30632707/tactile-hypersensitivity-and-gaba-concentration-in-the-sensorimotor-cortex-of-adults-with-autism
#2
Laurie-Anne Sapey-Triomphe, Franck Lamberton, Sandrine Sonié, Jérémie Mattout, Christina Schmitz
Sensory hypersensitivity is frequently encountered in autism spectrum disorder (ASD). Gamma-aminobutyric acid (GABA) has been hypothesized to play a role in tactile hypersensitivity. The aim of the present study was twofold. First, as a study showed that children with ASD have decreased GABA concentrations in the sensorimotor cortex, we aimed at determining whether the GABA reduction remained in adults with ASD. For this purpose, we used magnetic resonance spectroscopy to measure GABA concentration in the sensorimotor cortex of neurotypical adults (n = 19) and ASD adults (n = 18)...
January 11, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/30632321/brief-social-attention-bias-modification-for-children-with-autism-spectrum-disorder
#3
Gail A Alvares, Nigel T M Chen, Lies Notebaert, Joanna Granich, Ciara Mitchell, Andrew J O Whitehouse
Reduced social attention is a hallmark feature in autism spectrum disorder (ASD), emerging as early as the first year of life. This difference represents a possible mechanism impacting upon the development of more complex social-communicative behaviors. The aim of this study was to develop and test the efficacy of a novel attention bias modification paradigm to alter social attention, specifically orienting to faces. Children with ASD (n = 66), aged between 5 and 12 years, were randomized to play either a social attention training or control game for 15 min...
January 10, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/30632299/comparing-the-1-year-impact-of-preschool-autism-intervention-programs-in-two-canadian-provinces
#4
Isabel M Smith, Helen E Flanagan, Wendy J Ungar, Barbara D'Entremont, Nancy Garon, Jeffrey den Otter, Charlotte Waddell, Susan E Bryson, Kate Tsiplova, Natalie Léger, Francine Vezina, Patricia Murray
Autism spectrum disorder (ASD) is associated with early differences in children's social interactions, communication, and play/interests. In many countries, considerable resources are invested in early intensive behavioral intervention (EIBI) programs for children with ASD, which aim to build adaptive skills and prevent or treat problem behavior. However, these programs vary widely in structure and delivery. Research evidence supports the efficacy of EIBI, but large knowledge gaps remain about the effectiveness of publicly funded EIBI programs...
January 10, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/30632286/social-complexity-and-the-early-social-environment-affect-visual-social-attention-to-faces
#5
Tawny Tsang, Scott Johnson, Shafali Jeste, Mirella Dapretto
Diminished attention to socially relevant information appears to be an early emerging risk factor associated with autism spectrum disorders (ASD). However, inconsistencies across studies suggest that atypicalities in visual social attention in infants at high-risk for ASD during the first postnatal year may be subtle and more apparent under certain contexts. Here we explore factors that may moderate developmental trajectories in attention to faces, including the social complexity of the dynamic visual stimuli used to measure visual social attention and the early social environment of the infant as indexed by parental affectedness of ASD-related traits...
January 10, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/30629807/the-neurobiological-presentation-of-anxiety-in-autism-spectrum-disorder-a-systematic-review
#6
REVIEW
Alana J McVey
Anxiety is common among people with autism and is associated with unique and additive challenges. Anxiety is thought to have neurobiological components, and measures of arousal in typical development have long been studied. Recently, neurobiological measures of anxiety in autism have begun to receive empirical evaluation, but results have not yet been examined together. This systematic review, therefore, summarizes the state of the research of the neurobiology of anxiety in autism. Studies published between 1999 and June 2017 were reviewed...
January 10, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/30629339/shank1-polymorphisms-and-snp-snp-interactions-among-shank-family-a-possible-cue-for-recognition-to-autism-spectrum-disorder-in-infant-age
#7
Shuang Qiu, Yan Li, Ye Bai, Jikang Shi, Heran Cui, Yulu Gu, Yaxuan Ren, Qian Zhao, Kaixin Zhang, Meihan Lu, Yihan Wang, Yong Li, Weijing Zhong, Xiaojuan Zhu, Yunkai Liu, Yi Cheng, Yichun Qiao, Yawen Liu
Autism spectrum disorder (ASD) is a serious lifelong neurodevelopmental disorder. ASD is diagnosed for children at the age of two. ASD diagnosis, as early as possible, lays the foundation for treatment and much better prognosis. Notably, gene-based test is an inherent method to recognize the potential infants with ASD before the age of two. To investigate whether SHANK family contributes to ASD prediction, on the basis of our previous studies of SHANK2 and SHANK3, we further investigated associations between SHANK1 polymorphisms and ASD risk as well as SNP-SNP interactions among SHANK family...
January 10, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/30629336/treatment-patterns-in-children-with-autism-in-the-united-states
#8
Brigitta U Monz, Richard Houghton, Kiely Law, Georg Loss
Children with autism receive different types of non-drug treatments. We aimed to describe caregiver-reported pattern of care and its variability by geography and healthcare coverage in a US-wide sample of children aged 3-17 years. We recruited caregivers from the Simons Foundation Powering Autism Research for Knowledge (SPARK) cohort. Two online questionnaires (non-drug treatment, Autism Impact Measure) were completed in September/October 2017. Primary outcome measures were caregiver-reported types and intensities of treatments (behavioral, developmental/relationship, speech and language (SLT), occupational, psychological, "other"; parent/caregiver training) in the previous 12 months...
January 10, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/30629333/inferring-power-and-dominance-from-dyadic-nonverbal-interactions-in-autism-spectrum-disorder
#9
Marius Kuschefski, Christine M Falter-Wagner, Gary Bente, Kai Vogeley, Alexandra Livia Georgescu
Research studies to date have revealed conflicting results with respect to the processing of nonverbal cues from social interactions in autism spectrum disorder (ASD). Therefore, the aim of the present study was to investigate the contribution of two important factors for the perception of dyadic social interactions, namely (a) the movement contingency and (b) the spatial context. To this end, 26 adult participants with ASD and 26 age-, sex-, and IQ-matched typically developed control participants observed animations presenting nonverbal interactions between two human virtual characters enacting power relationships...
January 10, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/30624024/the-role-of-alexithymia-in-parent-child-interaction-and-in-the-emotional-ability-of-children-with-autism-spectrum-disorder
#10
Andreia P Costa, Georges Steffgen, Claus Vögele
Children with autism spectrum disorder (ASD) have more emotional difficulties than typically developing (TD) children. Of all the factors that impact children's emotional development, parents, and the way they interact with their children, are of crucial importance. The present study compared the amount of parent-child interactions among 35 dyads of parents and their children with ASD and 41 dyads of parents and their TD children, aged between 3 and 13 years, during a frustration-eliciting situation. We further examined whether children's alexithymia is linked to parent-child interactions and whether parent-child interactions are linked to children's emotional difficulties...
January 9, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/30624021/aberrant-deep-connectivity-in-autism-a-cortico-subcortical-functional-connectivity-magnetic-resonance-imaging-study
#11
Jose O Maximo, Rajesh K Kana
The number of studies examining functional brain networks in Autism Spectrum Disorder (ASD) has risen over the last decade and has characterized ASD as a disorder of altered brain connectivity. However, these studies have focused largely on cortical structures, and only a few studies have examined cortico-subcortical connectivity in regions like thalamus and basal ganglia in ASD. The goal of this study was to characterize the functional connectivity between cortex and subcortical regions in ASD using the Autism Brain Imaging Data Exchange (ABIDE-II)...
January 9, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/30624017/dyadic-interactions-in-children-exhibiting-the-broader-autism-phenotype-is-the-broader-autism-phenotype-distinguishable-from-typical-development
#12
A M Kellerman, A J Schwichtenberg, B L Tonnsen, G Posada, S P Lane
In families raising a child with an autism spectrum disorder (ASD), infant siblings are at elevated risk for ASD and other developmental concerns, including elements of the broader autism phenotype (BAP). Typically, the BAP is indexed using standardized developmental assessments; however, these measures do not capture a number of social difficulties commonly associated with the BAP. The present study aims to expand our developmental understanding of the BAP by comparing children exhibiting the BAP to their typically developing peers on, (a) standardized measures of development, and (b) social behaviors exhibited during dyadic play interactions...
January 9, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/30618181/the-stability-of-joint-engagement-states-in-infant-siblings-of-children-with-and-without-asd-implications-for-measurement-practices
#13
Kristen Bottema-Beutel, So Yoon Kim, Shannon Crowley, Ashley Augustine, Bahar Kecili-Kaysili, Jacob Feldman, Tiffany Woynaroski
Obtaining stable estimates of caregiver-child joint engagement states is of interest for researchers who study development and early intervention in young children with autism spectrum disorder (ASD). However, studies to date have offered little guidance on the numbers of sessions and coders necessary to obtain sufficiently stable estimates of these constructs. We used procedures derived from G theory to carry out a generalizability study, in which we partitioned error variance between two facets of our system for measuring joint engagement states: session and coder...
January 8, 2019: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/30592171/psychometric-properties-of-the-chinese-version-of-autism-spectrum-quotient-children-s-version-a-sex-specific-analysis
#14
Fan Sun, Meixia Dai, Lizi Lin, Xiang Sun, Aja Louise Murray, Bonnie Auyeung, Jin Jing
A Simplified Chinese translation of the Autism Spectrum Quotient-Children's Version (AQ-C) is needed for research in mainland China. Autism Spectrum Disorder (ASD) is a condition that differs in presentation and prevalence by sex. Thus, evaluating the psychometric validity of the AQ-C in males and females is an important step in its validation. The present study aims to develop a Chinese translation of the parent-report AQ-C, and test its psychometric properties among Mandarin Chinese speaking boys and girls...
December 28, 2018: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/30585440/faster-eye-movements-in-children-with-autism-spectrum-disorder
#15
Klara Kovarski, Marine Siwiaszczyk, Joëlle Malvy, Magali Batty, Marianne Latinus
Atypical visual exploration of both social and nonsocial scenes is often reported in Autism Spectrum Disorder (ASD) with less precise and longer saccades, potentially reflecting difficulties in oculomotor control. To assess a subset of oculomotor functions in ASD, 20 children with ASD and 21 age-matched typically developing (TD) children (2.6-11.5 years) partook in three tasks of increasing complexity, while no explicit instruction was provided: a prosaccade gap task, a color and a "categorical" visual search tasks (a face among butterflies and vice-versa)...
December 26, 2018: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/30575327/maternal-pre-pregnancy-body-mass-index-and-gestational-weight-gain-in-relation-to-autism-spectrum-disorder-and-other-developmental-disorders-in-offspring
#16
Gayle C Windham, Meredith Anderson, Kristen Lyall, Julie L Daniels, Tanja V E Kral, Lisa A Croen, Susan E Levy, Chyrise B Bradley, Christina Cordero, Lisa Young, Laura A Schieve
Most prior studies examining maternal pre-pregnancy body mass index (BMI) in relation to offspring autism spectrum disorders (ASD) have reported an association, though findings are not uniform and few have also examined gestational weight gain (GWG). Therefore, we examined both in the Study to Explore Early Development, a multi-site case-control study of children born in 2003-2006. Children identified from clinics, schools, and birth certificates were enrolled at ages 2-5 year and using standardized developmental evaluations, classified as: ASD, other developmental delays (DD), or population-based controls...
December 21, 2018: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/30575312/adults-with-autism-spectrum-disorder-are-sensitive-to-the-kinematic-features-defining-natural-human-motion
#17
Rosanna Edey, Jennifer Cook, Rebecca Brewer, Geoffrey Bird, Clare Press
It has been hypothesized that individuals with Autism Spectrum Disorder (hereafter "autism") have problems perceiving biological motion, which contributes to their social difficulties. However, the ability to perceive the kinematic profile characteristic of biological motion has not been systematically examined in autism. To examine this basic perceptual ability we conducted two experiments comparing adults with autism with matched typical adults. In Experiment 1, participants indicated whether two movements-which differed in the quantity of formula-generated biological motion-were the same or different...
December 21, 2018: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/30575308/a-systematic-review-and-meta-regression-analysis-of-social-functioning-correlates-in-autism-and-typical-development
#18
REVIEW
Kristen Bottema-Beutel, So Yoon Kim, Shannon Crowley
Differences in social functioning are a hallmark feature of autism spectrum disorder (ASD), and much research has been devoted to locating cognitive and developmental explanations for this domain. To sort through this literature, we conducted a systematic review and meta-analysis that quantifies the extent to which several of these candidate constructs are associated with social functioning. We gathered 881 effect sizes calculated from 133 unique participant samples, and synthesized Pearson's r correlations between social functioning and three cognitive constructs; (a) theory of mind (ToM), (b) executive function, and (c) central coherence, and five developmental constructs: (d) initiating joint attention, (e) responding to joint attention, (f) imitation, (g) pretend play, and (h) visual fixation to social stimuli...
December 21, 2018: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/30575292/intact-counterfactual-emotion-processing-in-autism-spectrum-disorder-evidence-from-eye-tracking
#19
Jo Black, Mahsa Barzy, David Williams, Heather Ferguson
Counterfactual emotions, such as regret and relief, require an awareness of how things could have been different. We report a preregistered experiment that examines how adults with and without ASD process counterfactual emotions in real-time, based on research showing that the developmental trajectory of counterfactual thinking may be disrupted in people with ASD. Participants were eye-tracked as they read narratives in which a character made an explicit decision then subsequently experienced either a mildly negative or positive outcome...
December 21, 2018: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/30561910/integrative-analysis-of-transcriptome-wide-association-study-and-mrna-expression-profiles-identifies-candidate-genes-associated-with-autism-spectrum-disorders
#20
Huimei Huang, Shiqiang Cheng, Miao Ding, Yan Wen, Mei Ma, Lu Zhang, Ping Li, Bolun Cheng, Xiao Liang, Li Liu, Yanan Du, Yan Zhao, Om Prakash Kafle, Bei Han, Feng Zhang
Autism spectrum disorders (ASD) are a group of highly heritable psychiatric syndromes with high prevalence. The genetic mechanism of ASD remains elusive now. Here we conducted a transcriptome-wide association study (TWAS) of ASD. The GWAS summary data of ASD was driven from the Psychiatric Genomics Consortium (PGC) portal, totally involving 5,305 ASD cases and 5,305 controls. FUSION software was applied to the GWAS summary data for tissue-related TWAS of ASD considering brain and blood. The ASD associated genes identified by TWAS were further validated by mRNA expression profiling of ASD and the Simons Foundation for Autism Research (SFARI) Gene tool...
December 18, 2018: Autism Research: Official Journal of the International Society for Autism Research
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