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Ecancermedicalscience

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https://www.readbyqxmd.com/read/29910836/neoplasm-of-uncertain-behaviour-of-the-breast-a-retrospective-study-in-a-breast-unit
#1
Xavier de Sousa, Pedro Santos Ferreira, Luís Branco, Jorge Simões, Matilde Gonçalves, Manuel Vítor Rigueira, Luís Cortez
Introduction: Breast lesions include a heterogeneous group of entities with variable clinical behaviour and morphological presentation, mostly classified as benign or malignant, with predictable behaviour. However, there are lesions with clinical, breast imaging and/or biopsy characteristics that do not clarify their nature. These lesions have an uncertain behaviour regarding their malignant potential at diagnosis.We intend to relate the preoperative diagnosis of neoplasm of uncertain behaviour of the breast (NUnBB) regarding the core needle biopsy and the histological result after excisional biopsy...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29910835/supportive-care-needs-of-multicultural-patients-with-cancer-in-the-united-arab-emirates
#2
Satish Chandrasekhar Nair, Hassan Jaafar, Mohamed Jaloudi, Khaled Qawasmeh, Afra AlMarar, Halah Ibrahim
Despite the high prevalence of cancer in the Middle East, there is limited published data reporting the needs of cancer patients in this region of the world. The purpose of this study is to assess the unmet supportive care needs of oncology patients in the United Arab Emirates (UAE). From December 2014 to December 2016, a cross-sectional survey of cancer patients was conducted at a large tertiary care hospital and an oncology referral centre in the UAE, using a validated Arabic translation of the supportive care needs survey--short form (SCNS-SF34-A), assessing cancer-specific perceived needs across five domains: psychological, health system information, patient care and support, physical and daily living and sexuality...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29910834/lasting-pathologic-complete-response-to-chemotherapy-for-ovarian-cancer-after-receiving-antimalarials-for-dermatomyositis
#3
Isabella Cadena, Victoria P Werth, Pascale Levine, Annie Yang, Andrea Downey, John Curtin, Franco Muggia
Could hydroxychloroquine and quinacrine antimalarial therapy for dermatomyositis later attributed to a paraneoplasic manifestation of an ovarian cancer enhance its subsequent response to chemotherapy? Five months after being diagnosed with dermatomyositis, while somewhat improved with hydroxychloroquine, quinacrine and methotrexate, this 63-year-old woman presented with an advanced intra-abdominal epithelial ovarian cancer documented (but not resected) at laparotomy. Neoadjuvant carboplatin/paclitaxel resulted in remarkable improvement of symptoms, tumour markers and imaging findings leading to thorough cytoreductive surgery at completion of five cycles...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29910833/cryptococcal-meningoencephalitis-in-patients-with-mantle-cell-lymphoma-on-ibrutinib
#4
Kai Sun, Saro Kasparian, Swaminathan Iyer, Sai Ravi Pingali
Ibrutinib, a Bruton's tyrosine kinase inhibitor, has been increasingly widely used in relapsed and refractory mantle cell lymphoma (MCL) and chronic lymphocytic leukaemia [1, 2]. With its use becoming more common, there have been emerging case reports of opportunistic infections like cryptococcal infections [3-8]. These infections in patients receiving ibrutinib were mostly reported in patients with chronic lymphocytic leukaemia, who have poor immune reconstitution. Here, we report two cases of cryptococcal meningoencephalitis in patients with MCL on ibrutinib...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29910832/phase-i-ii-study-on-kilovoltage-surface-brachytherapy-in-conjunctival-cancer-preliminary-results
#5
Gustavo R Sarria, Gustavo J Sarria, Paola Fuentes Rivera, Mayer Zaharia, Solón Serpa, Mario Buitrago
Introduction: In ocular conjunctival carcinoma after surgery, adjuvant treatment has a role and kilovoltage surface brachytherapy opens a new door for the range of therapeutic options. Materials and methods: Between October 2014 and June 2017, at the National Institute of Neoplastic Diseases (INEN) from Peru, 39 patients with squamous cell carcinoma of ocular conjunctiva, T1-T3, resected, were selected to receive adjuvant treatment. The portable accelerator of 50-kV INTRABEAM (Carl Zeiss Meditec) was used, after local anaesthesia and blocking of ocular muscles movement...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29910831/postoperative-radiotherapy-after-nipple-or-skin-sparing-mastectomy-a-review-of-recent-institutional-and-pooled-data
#6
REVIEW
Jacques Bernier
The increasing use of nipple-sparing mastectomy (NSM) and skin-sparing mastectomy (SSM) in the treatment of nonmetastatic breast cancer is justified by considerations linked to their therapeutic index. In selected patients, efficacy results tend to be similar to those observed after radical modified mastectomy and at the same time, subcutaneous mastectomies preserve the patient's body image. Yet the oncologic safety of the two former surgical approaches is still a matter of debate, also in consideration of the almost complete absence of clinical studies directed to prospective, controlled comparisons between subcutaneous and radical modified mastectomies...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29910830/aggressive-breast-fibromatosis-following-augmentation-mastoplasty-a-series-of-case-reports
#7
REVIEW
Rafael Delgado Morales, Armando Gil Mendoza, Carmen Luces, Efren Bolívar Abreu, Gabriel Romero, Gabriel Pérez, Leonardo Russo
Aggressive fibromatosis comprises connective tissue tumours that represent 0.03% of all bodily neoplasms, occurring more often in the abdominal wall, mesentery, and extremities; its location in the breast constitutes a very infrequent type of lesion. Its pathogenesis is diverse and its relationship with augmentation mastoplasty is still unclear. Four cases of aggressive breast fibromatosis following augmentation mastoplasty are reported in this article.
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29910829/successful-treatment-of-a-stage-iiic-small-cell-carcinoma-of-the-ovary-hypercalcemic-subtype-using-multi-modality-therapeutic-approach
#8
Qian Qin, Veronica B Ajewole, Tiffany G Sheu, Rachel Donohue, Monisha Singh
Small-cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare but highly undifferentiated, aggressive malignancy that primarily affects young women. Due to its early onset, unclear familial history and vague presenting symptoms, most SCCOHT patients present late with advanced disease. The prognosis is extremely poor, with <10% disease-free survival for advanced stages. Although several therapeutic regimens have been proposed, to date there is no consensus on the optimal strategy. Here, we describe a successful case of advanced-stage SCCOHT of the left ovary treated with cytoreductive surgery, semi-intense chemotherapy, high-dose consolidative chemotherapy, autologous hematopoietic stem cell transplantation and pelvic radiation with long-term survival...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29743951/palliative-chemotherapy-outcomes-in-patients-with-ecog-ps-higher-than-1
#9
Rafael Caires-Lima, Karolina Cayres, Bruno Protásio, Inacelli Caires, Júlia Andrade, Lucila Rocha, Tiago Kenji Takahashi, Paulo M Hoff, Gilberto de Castro, Milena Perez Mak
Purpose: Although patients with incurable disease and Eastern Cooperative Oncology Group performance status (ECOG-PS ≥ 2) are underrepresented in clinical trials, they are frequently offered palliative chemotherapy (pCT) in daily clinical practice in order to improve symptoms and quality of life. In this case-control retrospective analysis, our goal was to identify factors associated with poorer survival and lack of benefit of pCT in this population. Patients and methods: We evaluated 2,514 patients who died between August 2011 and July 2012 in an academic cancer care institution and its hospice...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29743950/multimodality-management-of-leiomyosarcoma-of-the-cervix
#10
Vijaya Kumar Jayaram, J Parikshith, Geeta Sowmya Narayanan, Richa Tiwari, R Veena, S Prathima, M S Ganesh, Chattakonda Sai Snehith, Esther Praisy
We present the case of a young female patient who presented to the outpatient department with a history of bleeding per vagina, diagnosed with leiomyosarcoma of the cervix; the patient underwent total abdominal hysterectomy with pelvic lymph node dissection. In this article, we mainly discuss multimodality therapy in the management of an unusual variety of tumour in the uterine cervix.
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29743949/favourable-response-of-serum-prostate-specific-antigen-to-conjugated-oestrogen-in-castrate-resistant-prostate-cancer-in-jamaica
#11
Andrew Condappa, Maxine Gossell-Williams, William Aiken
Conjugated oestrogen is one of the more affordable secondary hormonal options available for castrate-resistant prostate cancer (CRPC) in Jamaica. The present study was conducted to examine the disease response in Jamaican men with CRPC treated with conjugated oestrogen. This study retrospectively reviewed the medical notes of patients who attended the urologic clinic of the University Hospital of the West Indies from 1 January 2009 to 31 December 2013 and a private urology clinic from 2 November 2005 to 3 June 2015 to identify patients diagnosed with CRPC treated with conjugated oestrogen (Premarin ®) as secondary therapy...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29743948/the-current-state-of-prostate-cancer-treatment-in-trinidad-and-tobago
#12
REVIEW
Satyendra Persaud, Maliza Persaud, Lester Goetz, Dylan Narinesingh
Prostate cancer mortality in the Caribbean region is among the highest in the world and prostate cancer is the most common cancer in Trinidad and Tobago. There is a two-tiered healthcare system in Trinidad and Tobago, and prostate cancer related issues account for a significant percentage of urologists' workload. Delivery of care is sometimes constrained by limited financial resources. Prostate-specific antigen testing is widely available but there is no national guideline. Treatment options available include active surveillance, radical prostatectomy, external beam radiotherapy and brachytherapy...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29743947/nursing-intervention-in-women-who-developed-lymphedema-after-undergoing-a-modified-radical-mastectomy-a-pre-experimental-study
#13
Gloria Daniela de la Borbolla Martínez, Martha Elena Huitzache Martínez, Nicolás Padilla Raygoza
The aim of this study was to analyse the effect of a nursing intervention in increasing the therapeutic self-care demand in patients with breast cancer-related lymphedema after a mastectomy. The pre-experiment was carried out on women in the State Cancer Institute in Colima, Mexico. Thirty women who had undergone a mastectomy were included in this study. Each woman received a nursing intervention to increase her knowledge, skills and motivation, which are the components of therapeutic self-care demand. Students' t and P values were calculated for paired means, and the McNemar X2 test was performed for paired categorical variables...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29743946/cancer-treatment-in-the-last-6-months-of-life-when-inaction-can-outperform-action
#14
Bishal Gyawali, Saroj Niraula
When an investigational anticancer drug is being tested, demonstration of improvement in overall survival (OS) will generally lead to regulatory approval. However, the value that improvement in OS adds to patients' lives is guided largely by the context of the improvement and accompanying trade-offs. For example, when a patient's life expectancy is less than 6 months, many oncologists will not embark on any active cancer treatments. However, multiple new anticancer drugs have been approved recently after being tested in end-stage cancer patients and demonstrating median OS in the experimental arm close to 6 months...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29743945/evidence-on-the-cost-of-breast-cancer-drugs-is-required-for-rational-decision-making
#15
Anne Margreet Sofie Berghuis, Hendrik Koffijberg, Leonardus Wendelinus Mathias Marie Terstappen, Stefan Sleijfer, Maarten Joost IJzerman
Background: For rational decision making, assessing the cost-effectiveness and budget impact of new drugs and comparing the costs of drugs already on the market is required. In addition to value frameworks, such as the American Society of Clinical Oncology Value Framework and the European Society of Medical Oncology-Magnitude of Clinical benefit Scale, this also requires a transparent overview of actual drug prices. While list prices are available, evidence on treatment cost is not. This paper aims to synthesise evidence on the reimbursement and costs of high-cost breast cancer drugs in The Netherlands (NL)...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29743944/repurposing-drugs-in-oncology-redo-selective-pde5-inhibitors-as-anti-cancer-agents
#16
Pan Pantziarka, Vidula Sukhatme, Sergio Crispino, Gauthier Bouche, Lydie Meheus, Vikas P Sukhatme
Selective phosphodiesterase 5 inhibitors, including sildenafil, tadalafil and vardenafil, are widely-used in the treatment of erectile dysfunction and pulmonary arterial hypertension. They are also well-known as examples of successful drug repurposing in that they were initially developed for angina and only later developed for erectile dysfunction. However, these drugs may also be effective cancer treatments. A range of evidentiary sources are assessed in this paper and the case made that there is pre-clinical and clinical evidence that these drugs may offer clinical benefit in a range of cancers...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29743943/risk-sharing-agreements-present-and-future
#17
REVIEW
Francisco R Gonçalves, Susana Santos, Catarina Silva, Gabriela Sousa
Risk-sharing agreements between pharmaceutical companies and payers stand out as a recent practice, the use of which has been increasing in the case of innovative medicines, particularly in the field of oncology, which aims to ensure better budgetary control and a lower risk of spending on medicinal products without full evidence of clinical benefit. In this article, the authors discuss the types of existing agreements, as well as those used in Portugal, their advantages, disadvantages and future challenges of implementation, as well as their potential role in access to therapeutic innovation, namely medicines for cancer treatment...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29662537/untire-an-all-embracing-self-management-ehealth-program-to-cope-with-cancer-related-fatigue
#18
EDITORIAL
Abraham Johannes Kuiper, Maria Dorothea Jacoba Wolvers, Dora Vonk, Anton Hagenbeek
Cancer-related fatigue (CRF) is a frequent and invalidating problem in (former) cancer patients. If there are no medical causes, relief of fatigue can be attained by means of non-pharmacological interventions. Guidelines prescribe a multimodal approach with a focus on mental processes, physical activity and sleep. Online interventions have been shown to be effective in reducing CRF. These results inspired the creation of an all-embracing app on the various behavioural and physical activity modification themes that are recommended in oncological guidelines...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29662536/attrition-as-one-of-the-challenges-of-developing-a-palliative-care-centre-experience-of-the-indian-institute-of-head-and-neck-oncology-indore-india
#19
EDITORIAL
Digpal Dharkar
Palliative care is an essential component of health care delivery. With respect to India, currently, despite rapid socio economic development, there are tremendous challenges in offering institutional palliative care due to several factors. A major factor has been an acute shortage of trained palliative care professionals. Another has been the fact that the majority of India's population is not covered by any health insurance. We describe the problems, including attrition faced by the Indian Institute of Head and Neck Oncology, in the central Indian state of Madhya Pradesh...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29662535/adipose-tissue-stem-cells-in-regenerative-medicine
#20
REVIEW
Vanesa Verónica Miana, Elio A Prieto González
Adipose tissue-derived stem cells (ADSCs) are mesenchymal cells with the capacity for self-renewal and multipotential differentiation. This multipotentiality allows them to become adipocytes, chondrocytes, myocytes, osteoblasts and neurocytes among other cell lineages. Stem cells and, in particular, adipose tissue-derived cells, play a key role in reconstructive or tissue engineering medicine as they have already proven effective in developing new treatments. The purpose of this work is to review the applications of ADSCs in various areas of regenerative medicine, as well as some of the risks associated with treatment with ADSCs in neoplastic disease...
2018: Ecancermedicalscience
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