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Ecancermedicalscience

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https://www.readbyqxmd.com/read/28194230/what-are-the-personal-and-professional-characteristics-that-distinguish-the-researchers-who-publish-in-high-and-low-impact-journals-a-multi-national-web-based-survey
#1
Carlos Eduardo Paiva, Raphael L C Araujo, Bianca Sakamoto Ribeiro Paiva, Cristiano de Pádua Souza, Flavio Mavignier Cárcano, Marina Moreira Costa, Sérgio Vicente Serrano, João Paulo Nogueira Lima
PURPOSE: This study identifies the personal and professional profiles of researchers with a greater potential to publish high-impact academic articles. METHOD: The study involved conducting an international survey of journal authors using a web-based questionnaire. The survey examined personal characteristics, funding, and the perceived barriers of research quality, work-life balance, and satisfaction and motivation in relation to career. The processes of manuscript writing and journal publication were measured using an online questionnaire that was developed for this study...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28194229/circulating-and-tissue-biomarkers-in-early-stage-non-small-cell-lung-cancer
#2
Caterina Fumagalli, Fabrizio Bianchi, Paola Rafaniello Raviele, Davide Vacirca, Giovanni Bertalot, Cristiano Rampinelli, Matteo Lazzeroni, Bernardo Bonanni, Giulia Veronesi, Nicola Fusco, Massimo Barberis, Elena Guerini-Rocco
OBJECTIVE: We sought to characterise circulating and tissue tumour biomarkers of patients who developed early-stage non-small cell lung cancer (NSCLC) during long-term follow-up of a chemoprevention trial (NCT00321893). MATERIALS AND METHODS: Blood and sputum samples were collected from 202 high-risk asymptomatic individuals with CT-detected stable lung nodules. Real-time PCR was performed on plasma to quantify free circulating DNA. Baseline serum was investigated with a previously validated test based on 13 circulating miRNAs (miR-Test)...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28194228/guidelines-for-the-management-of-neuroendocrine-tumours-by-the-brazilian-gastrointestinal-tumour-group
#3
Rachel P Riechelmann, Rui F Weschenfelder, Frederico P Costa, Aline Chaves Andrade, Alessandro Bersch Osvaldt, Ana Rosa P Quidute, Allan Dos Santos, Ana Amélia O Hoff, Brenda Gumz, Carlos Buchpiguel, Bruno S Vilhena Pereira, Delmar Muniz Lourenço Junior, Duilio Reis da Rocha Filho, Eduardo Antunes Fonseca, Eduardo Linhares Riello Mello, Fabio Ferrari Makdissi, Fabio Luiz Waechter, Francisco Cesar Carnevale, George B Coura-Filho, Gustavo Andrade de Paulo, Gustavo Colagiovanni Girotto, João Evangelista Bezerra Neto, João Glasberg, Jose Claudio Casali-da-Rocha, Juliana Florinda M Rego, Luciana Rodrigues de Meirelles, Ludhmila Hajjar, Marcos Menezes, Marcello D Bronstein, Marcelo Tatit Sapienza, Maria Candida Barisson Villares Fragoso, Maria Adelaide Albergaria Pereira, Milton Barros, Nora Manoukian Forones, Paulo Cezar Galvão do Amaral, Raphael Salles Scortegagna de Medeiros, Raphael L C Araujo, Regis Otaviano França Bezerra, Renata D'Alpino Peixoto, Samuel Aguiar, Ulysses Ribeiro, Tulio Pfiffer, Paulo M Hoff, Anelisa K Coutinho
Neuroendocrine tumours are a heterogeneous group of diseases with a significant variety of diagnostic tests and treatment modalities. Guidelines were developed by North American and European groups to recommend their best management. However, local particularities and relativisms found worldwide led us to create Brazilian guidelines. Our consensus considered the best feasible strategies in an environment involving more limited resources. We believe that our recommendations may be extended to other countries with similar economic standards...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28194227/bone-metastasis-risk-factors-in-breast-cancer
#4
REVIEW
Catarina Pulido, Inês Vendrell, Arlindo R Ferreira, Sandra Casimiro, André Mansinho, Irina Alho, Luís Costa
Bone is the single most frequent site for bone metastasis in breast cancer patients. Patients with bone-only metastasis have a fairly good prognosis when compared with patients with visceral disease. Nevertheless, cancer-induced bone disease carries an important risk of developing skeletal related events that impact quality of life (QoL). It is therefore particularly important to stratify patients according to their risk of developing bone metastasis. In this context, several risk factors have been studied, including demographic, clinicopathological, genetic, and metabolic factors...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28144288/gastric-cancer-and-related-epigenetic-alterations
#5
REVIEW
Trupti N Patel, Soumyadipta Roy, Revathi Ravi
Gastric cancer, a malignant and highly proliferative condition, has significantly affected a large population around the globe and is known to be caused by various factors including genetic, epigenetic, and environmental influences. Though the global trend of these cancers is declining, an increase in its frequency is still a threat because of changing lifestyles and dietary habits. However, genetic and epigenetic alterations related to gastric cancers also have an equivalent contribution towards carcinogenic development...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28144287/estimation-of-life-expectancy-of-patients-diagnosed-with-the-most-common-cancers-in-the-valparaiso-region-chile
#6
C Taramasco, K Figueroa, Y Lazo, J Demongeot
BACKGROUND: The 1000s of people who die from cancer each year have become one of the leading causes of death among the Chilean population, placing it as the second cause of death in the region of Valparaiso between 1997 and 2003. Statistics have provided different measures regarding the life expectancy of cancer patients which have resulted in being useful to establish courses of action for prevention and treatment plans to follow. METHODS: Data was extracted from the cancer module of the Epidemiology Assistance System (SADEPI for its initials in Spanish) which stores information about cancer cases in the provinces of Valparaiso and Petorca...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28144286/study-of-clinical-haematological-and-cytogenetic-profile-of-patients-with-acute-erythroid-leukaemia
#7
Jacob Abraham Linu, Ms Namratha Udupa, D S Madhumathi, K C Lakshmaiah, K Govind Babu, D Lokanatha, Mc Suresh Babu, K N Lokesh, L K Rajeev, A H Rudresha
BACKGROUND: Acute erythroid leukaemia (AEL) is a rare subtype of acute myeloid leukaemia (AML), constituting <5% of all the cases of AML. The World Health Organization (WHO) in 2001 classified AEL into two types: (1) erythroid/myeloid leukaemia which required ≥50% erythroid precursors with ≥20% of the non-erythroid cells to be myeloid blasts and (2) pure erythroleukemia (pEL) with ≥80% erythroblasts. The WHO 2008 classification kept these subcategories, but made erythroleukemia a diagnosis of exclusion...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28144285/the-presence-of-primary-circulating-prostate-cells-is-associated-with-upgrading-and-upstaging-in-patients-eligible-for-active-surveillance
#8
Nigel P Murray, Eduardo Reyes, Cynthia Fuentealba, Socrates Aedo, Omar Jacob
: Active surveillance (AS) is a considered treatment option for men with low or very low-risk prostate cancer. However, on repeat biopsy some 25% were upgraded and recommended for active treatment. We compare the presence or absence of primary circulating prostate cells (CPCs) with the clinical pathological findings after radical prostatectomy in men fulfilling the criteria for active surveillance and the risk of reclassification for active observation (AO). METHODS AND PATIENTS: A single centre observational study was done involving 102 men who fulfilled the Epstein criteria for AS and underwent radical prostatectomy as mono-therapy for prostate cancer...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28144284/balancing-health-care-needs-in-a-changing-context-nursing-highlights-from-the-2016-european-oncology-nursing-society-congress-eons10-17-18-october-2016-dublin-ireland
#9
Danuta Lichosik, Rosario Caruso
European cancer nurses have to face many challenges as a result of the rapidly changing economic and political context in which balancing health care needs has become strategic for healthcare delivery. Currently, cancer nurses must overcome many obstacles arising from clinical, organisational, and educational issues. Within this scenario, the European Oncology Nursing Society (EONS) shaped its tenth congress programme to boost discussion and reflections, to share experiences and research, and to see how cancer nurses try to anticipate and embrace changes...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28144283/the-impact-of-the-eu-general-data-protection-regulation-on-scientific-research
#10
Gauthier Chassang
The use of personal data is critical to ensure quality and reliability in scientific research. The new Regulation [European Union (EU)] 2016/679 of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data [general data protection regulation (GDPR)], repealing Directive 95/46/EC, strengthens and harmonises the rules for protecting individuals' privacy rights and freedoms within and, under certain conditions, outside the EU territory...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28105079/hepatocellular-carcinoma-in-identical-twins-in-chile-case-report
#11
Christian Caglevic, Shirley Silva, Mauricio Mahave, Javiera Torres, Christian Rolfo, Jorge Gallardo, Paula Carrasco
Liver cancer is the second leading cause of cancer death worldwide, with hepatocellular carcinoma (HCC) being the most common type of primary malignant liver tumour, with a typically poor prognosis, growing incidence and a well-documented relationship with chronic inflammation factors of the liver tissue. Despite the fact that family medical history has been identified as a risk factor for the development of HCC, its significance in terms of etiopathogenesis and prognosis is not well documented. With a view to contributing to this discussion, we will report the clinical case of two identical twins with HCC, both diagnosed within a short period of time, by providing relevant clinical data, and relating this to other medical literature reports that could contribute to a deeper understanding of this illness...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/28105078/the-current-situation-for-gastric-cancer-in-chile
#12
REVIEW
Christian Caglevic, Shirley Silva, Mauricio Mahave, Christian Rolfo, Jorge Gallardo
Gastric cancer is a neoplasm with a high incidence and mortality rate in Chile where more than 3000 people die every year from this type of cancer. This study shows the clinical and epidemiological considerations of this disease, information about translational research on this pathology in Chile, the contribution of Chilean doctors to the development of gastric cancer management awareness and the general situation of gastric cancer in Chile.
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/28105077/why-a-d2-gastrectomy-plus-adjuvant-chemotherapy-is-insufficient-in-locally-advanced-gastric-cancer
#13
REVIEW
Z Sebastián Solé, Francisco E Larsen, Claudio V Solé
This review discusses all the important published evidence regarding adjuvant treatments in locally advanced gastric cancer. In this process it revealed facts that demonstrate the superiority of radiotherapy and concomitant chemotherapy to chemotherapy alone. Some outstanding work that has not yet been published is also discussed.
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/28105076/central-nervous-system-metastasis-secondary-to-colorectal-cancer-a-retrospective-cohort-study-of-20-cases
#14
REVIEW
Sebastián Mondaca, Valentina Hornig, Pablo Munoz-Schuffenegger, Francisco Acevedo, Marcelo Garrido, Bruno Nervi
INTRODUCTION: Involvement of the central nervous system (CNS) secondary to colorectal cancer is infrequent and associated with a poor prognosis. Its treatment is extrapolated from metastases of other origins as the information available on this scenario is limited. The goal of this study is to assess the clinical characteristics of a series of patients and determine the results in terms of progression-free survival (PFS) and global survival. METHOD: The records of patients with CNS metastasis of colorectal origin who were treated in this facility between the years 2001 and 2016 were reviewed retrospectively...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/28105075/cancer-of-the-gallbladder-chilean-statistics
#15
REVIEW
Luis Villanueva Olivares
Chile has the world's highest rate of incidence as well as death from cancer of the gallbladder and biliary ducts. The problem is most acute in the southern provinces. These areas constitute the low average income associated with low educational attainment and a high rate of obesity compared with the rest of Chile. We could also include genetic factors related to processes of lithogenesis to these elements which are more common among the Mapuche. This population sub-group could benefit from special government programmes for early diagnosis and treatment of lithiasic disease and for the management of risk factors such as obesity...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/28105074/biomarkers-come-of-age-pd1-in-the-frontline-and-cell-cycle-therapy-swells-the-ranks-of-personalised-therapy-in-the-european-society-of-medical-oncology-esmo-congress-copenhagen-7-10-october-2016
#16
Will Davies
After years of trials, Programmed Death Ligand and Receptor targeting finally debuts as a firstline therapy in combination and as a single agent regimen at the 2016 European Society of Medical Oncology (ESMO) Congress. The meeting brought together 20,522 attendees, from over 120 countries, to share updates and novel technologies from a wide swathe of oncology research. This year's theme, From Disease Treatment to Patient Care, was matched by abstract presentations starting from inception of care regimens to new standards of care in high-risk patient subgroups, to wellbeing of care providers, and finally the funding obstacles at each continental level...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/28105073/the-neutrophil-to-lymphocyte-ratio-a-narrative-review
#17
REVIEW
Sara Socorro Faria, Paulo César Fernandes, Marcelo José Barbosa Silva, Vladmir C Lima, Wagner Fontes, Ruffo Freitas-Junior, Agda Karina Eterovic, Patrice Forget
Cellular-mediated inflammatory response, lymphocytes, neutrophils, and monocytes are increasingly being recognised as having an important role in tumorigenesis and carcinogenesis. In this context, studies have suggested that the neutrophil-to-lymphocyte ratio (NLR) can be used as an independent prognostic factor in a variety of cancers. Particularly in breast cancer, several studies have shown that a high NLR is associated with shorter survival. Because the NLR can be easily determined from the full blood count, it could potentially provide a simple and inexpensive test cancer prognosis...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/28105072/cancer-and-the-metastatic-substrate
#18
REVIEW
Francisco Arvelo, Felipe Sojo, Carlos Cotte
Seventy percent of cancer patients have detectable metastases when they receive a diagnosis and 90% of cancer deaths result from metastases. These two facts emphasise the urgency for research to study the mechanisms and processes that enable metastasis. We need to develop a greater understanding of the cellular and molecular mechanisms that cause metastasis and also we need to do more. We must also consider the micro- and macro-environmental factors that influence this disease. Studying this environmental context has led us to update the 'seed and soil' hypothesis which dates back to the 19th century...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/28105071/an-australasian-perspective-on-the-curative-treatment-of-patients-with-pancreatic-cancer-supportive-care-and-future-directions-for-management
#19
REVIEW
Wendy Muircroft
The management of patients with pancreatic cancer requires an individualised approach and the support of a multidisciplinary team to accurately stage patients and determine their suitability for curative treatment. Guidelines have been developed in Australasia to define the operability for patients who have been diagnosed with pancreatic cancer. This is supported by advances in pancreatic cancer genetics, which show potential for developing targeted therapies for pancreatic cancer. Both surgery and targeted therapies aim to extend the overall survival of patients...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/28105070/replacing-5-fluorouracil-by-capecitabine-in-localised-squamous-cell-carcinoma-of-the-anal-canal-systematic-review-and-meta-analysis
#20
Karla T Souza, Allan Al Pereira, Raphael L Araujo, Suilane Coelho Ribeiro Oliveira, Paulo M Hoff, Rachel P Riechelmann
BACKGROUND: The standard treatment for localised squamous cell carcinoma of the anal canal (SCCAC) is chemoradiotherapy (CRT) with infusional 5-fluorouracil (5-FU) and mitomycin. Because 5-FU and capecitabine have offered similar efficacy in many phase-III trials of solid tumours, studies have tested capecitabine in this setting of SCCAC. However, these studies are small and have reported variable results. Therefore, a systematic review and meta-analysis was performed. METHODS: Medline, Scopus and Embase were searched for studies that evaluated the efficacy outcomes of capecitabine used as a substitute of 5-FU in the CRT of localised SCCAC...
2016: Ecancermedicalscience
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