journal
MENU ▼
Read by QxMD icon Read
search

Ecancermedicalscience

journal
https://www.readbyqxmd.com/read/29743951/palliative-chemotherapy-outcomes-in-patients-with-ecog-ps-higher-than-1
#1
Rafael Caires-Lima, Karolina Cayres, Bruno Protásio, Inacelli Caires, Júlia Andrade, Lucila Rocha, Tiago Kenji Takahashi, Paulo M Hoff, Gilberto de Castro, Milena Perez Mak
Purpose: Although patients with incurable disease and Eastern Cooperative Oncology Group performance status (ECOG-PS ≥ 2) are underrepresented in clinical trials, they are frequently offered palliative chemotherapy (pCT) in daily clinical practice in order to improve symptoms and quality of life. In this case-control retrospective analysis, our goal was to identify factors associated with poorer survival and lack of benefit of pCT in this population. Patients and methods: We evaluated 2,514 patients who died between August 2011 and July 2012 in an academic cancer care institution and its hospice...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29743950/multimodality-management-of-leiomyosarcoma-of-the-cervix
#2
Vijaya Kumar Jayaram, J Parikshith, Geeta Sowmya Narayanan, Richa Tiwari, R Veena, S Prathima, M S Ganesh, Chattakonda Sai Snehith, Esther Praisy
We present the case of a young female patient who presented to the outpatient department with a history of bleeding per vagina, diagnosed with leiomyosarcoma of the cervix; the patient underwent total abdominal hysterectomy with pelvic lymph node dissection. In this article, we mainly discuss multimodality therapy in the management of an unusual variety of tumour in the uterine cervix.
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29743949/favourable-response-of-serum-prostate-specific-antigen-to-conjugated-oestrogen-in-castrate-resistant-prostate-cancer-in-jamaica
#3
Andrew Condappa, Maxine Gossell-Williams, William Aiken
Conjugated oestrogen is one of the more affordable secondary hormonal options available for castrate-resistant prostate cancer (CRPC) in Jamaica. The present study was conducted to examine the disease response in Jamaican men with CRPC treated with conjugated oestrogen. This study retrospectively reviewed the medical notes of patients who attended the urologic clinic of the University Hospital of the West Indies from 1 January 2009 to 31 December 2013 and a private urology clinic from 2 November 2005 to 3 June 2015 to identify patients diagnosed with CRPC treated with conjugated oestrogen (Premarin ®) as secondary therapy...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29743948/the-current-state-of-prostate-cancer-treatment-in-trinidad-and-tobago
#4
REVIEW
Satyendra Persaud, Maliza Persaud, Lester Goetz, Dylan Narinesingh
Prostate cancer mortality in the Caribbean region is among the highest in the world and prostate cancer is the most common cancer in Trinidad and Tobago. There is a two-tiered healthcare system in Trinidad and Tobago, and prostate cancer related issues account for a significant percentage of urologists' workload. Delivery of care is sometimes constrained by limited financial resources. Prostate-specific antigen testing is widely available but there is no national guideline. Treatment options available include active surveillance, radical prostatectomy, external beam radiotherapy and brachytherapy...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29743947/nursing-intervention-in-women-who-developed-lymphedema-after-undergoing-a-modified-radical-mastectomy-a-pre-experimental-study
#5
Gloria Daniela de la Borbolla Martínez, Martha Elena Huitzache Martínez, Nicolás Padilla Raygoza
The aim of this study was to analyse the effect of a nursing intervention in increasing the therapeutic self-care demand in patients with breast cancer-related lymphedema after a mastectomy. The pre-experiment was carried out on women in the State Cancer Institute in Colima, Mexico. Thirty women who had undergone a mastectomy were included in this study. Each woman received a nursing intervention to increase her knowledge, skills and motivation, which are the components of therapeutic self-care demand. Students' t and P values were calculated for paired means, and the McNemar X2 test was performed for paired categorical variables...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29743946/cancer-treatment-in-the-last-6-months-of-life-when-inaction-can-outperform-action
#6
Bishal Gyawali, Saroj Niraula
When an investigational anticancer drug is being tested, demonstration of improvement in overall survival (OS) will generally lead to regulatory approval. However, the value that improvement in OS adds to patients' lives is guided largely by the context of the improvement and accompanying trade-offs. For example, when a patient's life expectancy is less than 6 months, many oncologists will not embark on any active cancer treatments. However, multiple new anticancer drugs have been approved recently after being tested in end-stage cancer patients and demonstrating median OS in the experimental arm close to 6 months...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29743945/evidence-on-the-cost-of-breast-cancer-drugs-is-required-for-rational-decision-making
#7
Anne Margreet Sofie Berghuis, Hendrik Koffijberg, Leonardus Wendelinus Mathias Marie Terstappen, Stefan Sleijfer, Maarten Joost IJzerman
Background: For rational decision making, assessing the cost-effectiveness and budget impact of new drugs and comparing the costs of drugs already on the market is required. In addition to value frameworks, such as the American Society of Clinical Oncology Value Framework and the European Society of Medical Oncology-Magnitude of Clinical benefit Scale, this also requires a transparent overview of actual drug prices. While list prices are available, evidence on treatment cost is not. This paper aims to synthesise evidence on the reimbursement and costs of high-cost breast cancer drugs in The Netherlands (NL)...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29743944/repurposing-drugs-in-oncology-redo-selective-pde5-inhibitors-as-anti-cancer-agents
#8
Pan Pantziarka, Vidula Sukhatme, Sergio Crispino, Gauthier Bouche, Lydie Meheus, Vikas P Sukhatme
Selective phosphodiesterase 5 inhibitors, including sildenafil, tadalafil and vardenafil, are widely-used in the treatment of erectile dysfunction and pulmonary arterial hypertension. They are also well-known as examples of successful drug repurposing in that they were initially developed for angina and only later developed for erectile dysfunction. However, these drugs may also be effective cancer treatments. A range of evidentiary sources are assessed in this paper and the case made that there is pre-clinical and clinical evidence that these drugs may offer clinical benefit in a range of cancers...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29743943/risk-sharing-agreements-present-and-future
#9
REVIEW
Francisco R Gonçalves, Susana Santos, Catarina Silva, Gabriela Sousa
Risk-sharing agreements between pharmaceutical companies and payers stand out as a recent practice, the use of which has been increasing in the case of innovative medicines, particularly in the field of oncology, which aims to ensure better budgetary control and a lower risk of spending on medicinal products without full evidence of clinical benefit. In this article, the authors discuss the types of existing agreements, as well as those used in Portugal, their advantages, disadvantages and future challenges of implementation, as well as their potential role in access to therapeutic innovation, namely medicines for cancer treatment...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29662537/untire-an-all-embracing-self-management-ehealth-program-to-cope-with-cancer-related-fatigue
#10
EDITORIAL
Abraham Johannes Kuiper, Maria Dorothea Jacoba Wolvers, Dora Vonk, Anton Hagenbeek
Cancer-related fatigue (CRF) is a frequent and invalidating problem in (former) cancer patients. If there are no medical causes, relief of fatigue can be attained by means of non-pharmacological interventions. Guidelines prescribe a multimodal approach with a focus on mental processes, physical activity and sleep. Online interventions have been shown to be effective in reducing CRF. These results inspired the creation of an all-embracing app on the various behavioural and physical activity modification themes that are recommended in oncological guidelines...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29662536/attrition-as-one-of-the-challenges-of-developing-a-palliative-care-centre-experience-of-the-indian-institute-of-head-and-neck-oncology-indore-india
#11
EDITORIAL
Digpal Dharkar
Palliative care is an essential component of health care delivery. With respect to India, currently, despite rapid socio economic development, there are tremendous challenges in offering institutional palliative care due to several factors. A major factor has been an acute shortage of trained palliative care professionals. Another has been the fact that the majority of India's population is not covered by any health insurance. We describe the problems, including attrition faced by the Indian Institute of Head and Neck Oncology, in the central Indian state of Madhya Pradesh...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29662535/adipose-tissue-stem-cells-in-regenerative-medicine
#12
REVIEW
Vanesa Verónica Miana, Elio A Prieto González
Adipose tissue-derived stem cells (ADSCs) are mesenchymal cells with the capacity for self-renewal and multipotential differentiation. This multipotentiality allows them to become adipocytes, chondrocytes, myocytes, osteoblasts and neurocytes among other cell lineages. Stem cells and, in particular, adipose tissue-derived cells, play a key role in reconstructive or tissue engineering medicine as they have already proven effective in developing new treatments. The purpose of this work is to review the applications of ADSCs in various areas of regenerative medicine, as well as some of the risks associated with treatment with ADSCs in neoplastic disease...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29662534/obesity-and-outcome-of-post-menopausal-women-receiving-adjuvant-letrozole-for-breast-cancer
#13
Jamal Zekri, Kamel Farag, Ahmed Allithy
Introduction: Aromatase enzyme activity is predominant in adipose tissue. This has led to speculation that aromatase activity is elevated in obese women and subsequently decreased the clinical activity of adjuvant aromatase inhibitors (AIs) in women with estrogen receptor positive (ER+) breast cancer (BC). We investigated the effect of obesity on the outcome of this population. Patients and methods: Records of 320 consecutive post-menopausal (PM) women with ER+ BC starting single agent adjuvant letrozole between years 2005 and 2014 were retrospectively reviewed...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29662533/highlights-from-the-10th-breast-gynaecological-and-immunotherapy-international-cancer-conference-bgicc-18-19-january-2018-cairo-egypt
#14
Hesham El-Ghazaly, Adel Aref, Nermeen Bahie-Eldin
During the 10th Breast, Gynaecological and Immunotherapy International Cancer Conference (BGICC), which was held on 18 and 19 of January, 2018, in Cairo, Egypt, around 100 international, regional and national experts presented the latest updates in breast cancer, gynaecological cancers and immunotherapy in oncology. Through this report, we will try to highlight the important data and consensus issues that were discussed during the conference.
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29662532/cosmesis-after-early-stage-breast-cancer-treatment-with-surgery-and-radiation-therapy-experience-of-patients-treated-in-a-chilean-radiotherapy-centre
#15
Lorena Vargas, Sebastián Solé, Claudio Vicente Solé
Aim: To analyse the overall cosmetic outcome according to patient self-assessment in relation to the fractionation received. Materials and methods: A questionnaire, drawn up on the basis of subjective rating scales of cosmesis and of acute and late toxicity RTOG/EORTC, EORTC QLQ-C30 (v3) and LENT SOMA, was applied to patients with early-stage breast cancer who received radiotherapy with tangential fields between June 2014 and July 2015. Self-perception of cosmesis, changes in the treated breast, pain and fractionation used (hypofractionation (HF) 42...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29662531/cystic-brain-metastases-in-alk-rearranged-non-small-cell-lung-cancer
#16
REVIEW
Guilherme Nader Marta, Renata Rodrigues da Cunha Colombo Bonadio, Renata Eiras Martins, Henrique Bortot Zuppani, Gilberto de Castro
The central nervous system (CNS) is a common site of disease progression in patients with non-small-cell lung cancer (NSCLC) with anaplastic lymphoma kinase (ALK)-rearrangement treated with crizotinib. Cystic brain metastases (CBM) have been recently identified as one possible variant of this disease. An illustrative case report is presented along with a literature review performed in order to track relevant papers about CBM in ALK-rearranged NSCLC, including possible pathophysiology, differential diagnosis and treatment options for this condition...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29662530/are-we-ready-for-routine-precision-medicine-highlights-from-the-milan-summit-on-precision-medicine-milan-italy-8-9-february-2018
#17
Luca Mazzarella
On 8 and 9 February 2018, the IFOM-IEO campus in Milan hosted the Milan summit on Precision Medicine, which gathered clinical and translational research experts from academia, industry and regulatory bodies to discuss the state of the art of precision medicine in Europe. The meeting was pervaded by a generalised feeling of excitement for a field that is perceived to be technologically mature for the transition into clinical routine but still hampered by numerous obstacles of a methodological, ethical, regulatory and possibly cultural nature...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29662529/neoadjuvant-chemotherapy-in-locally-advanced-duodenal-adenocarcinoma
#18
Carlos Velandia, Rafael Delgado Morales, Carlos Coello, Armando Gil Mendoza, Gabriel Pérez, Emperatriz Aguero
Duodenal adenocarcinoma (ADC) represents only 0.3% of gastrointestinal neoplasms. With the frequency being higher between the ages of 40 and 60, it is predominantly located in the second part of the duodenum and around the periampullary region. Symptoms are nonspecific, so the majority of patients present with advanced disease. Neoadjuvant chemotherapy is a therapeutic option that has not been well studied. The global literature includes only isolated reports on this subject. This is why we are presenting the following case: a 60-year-old female patient with a locally advanced, inoperable duodenal ADC received neoadjuvant chemotherapy...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29662528/oncoplastic-surgery-for-the-conservative-treatment-of-breast-cancer-in-per%C3%A3%C2%BA-s-national-cancer-institute
#19
Gonzalo Javier Ziegler Rodriguez, Marcelo Diaz Chavez, Gabriela Guadalupe Calderon Valencia, Jose Manuel Cotrina Concha, Milko Raphael Garces Castre, Raul Mantilla
Background: Oncoplastic surgery for breast cancer (OPS) has been a surgical trend for the past 25 years. In 2012, OPS has been introduced as the standard treatment for a selected group of patients at the National Cancer Institute of Peru (INEN). The aim of this study is to describe our findings. Methods: This is a retrospective and descriptive study that identified demographics, tumour-pathologic features and includes patients solely treated since diagnosis until late follow-up at INEN...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29515656/rediscovery-in-science-a-second-eureka-moment-a-case-in-the-neovascularization-in-cancer
#20
EDITORIAL
Denys N Wheatley
Rediscoveries are not uncommon. However, sometimes they can be more significant than confirmatory or extensions of existing findings, although many authors today refer to them as discoveries in their own right. This has led to papers repeatedly rehearsing the expression "we show here for the first time…". When a finding has opened up a whole new field of research, this is more in line with a true discovery. When particular attention is drawn to such an event by editorials in widely read journals, such as Nature , its importance is bolstered...
2018: Ecancermedicalscience
journal
journal
41838
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"