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Ecancermedicalscience

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https://www.readbyqxmd.com/read/28275394/the-potential-consequences-for-cancer-care-and-cancer-research-of-brexit
#1
EDITORIAL
Peter Selby, Mark Lawler, Richard Baird, Ian Banks, Patrick Johnston, Paul Nurse
Following the UK "Brexit" vote in June 2016, there are many uncertainties and risks for cancer research and cancer care in the UK. These are summarised and the importance of sustained engagement and influence from the cancer community on UK governments is emphasised.
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28275393/psychological-impact-of-fertility-preservation-techniques-in-women-with-gynaecological-cancer
#2
EDITORIAL
Antonio Simone Laganà, Valentina Lucia La Rosa, Agnese Maria Chiara Rapisarda, Alessio Platania, Salvatore Giovanni Vitale
Gynaecological cancer is a very stressful experience for women and treatments can compromise fertility and reproductive capacity. Fertility preservation techniques in women with gynaecological cancer can play an important role in improving the quality of life of these patients but, in many cases, the information about this type of treatment is not adequate. It is important to further investigate this topic in order to reduce the impact of gynaecological cancer on the quality of life of survivors as much as possible...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28275392/clinical-response-in-patients-with-ovarian-cancer-treated-with-metronomic-chemotherapy
#3
Herman Andrés Perroud, O Graciela Scharovsky, Viviana Rosa Rozados, Carlos María Alasino
Ovarian cancer (OC) is the leading cause of death from gynaecological cancer. It is extremely hard to diagnose in the early stages and around 70% of patients present with advanced disease. Metronomic chemotherapy (MCT) is described as the chronic administration of, generally low, equally spaced, doses of chemotherapeutic drugs with therapeutic efficacy and low toxicity. This is an effective and low-cost way to treat several types of tumours, including ovarian cancer. Here, we present six cases of advanced ovarian cancer treated with MCT with low doses of cyclophosphamide, which showed clinical response and stable disease...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28275391/perceived-utility-of-an-integrated-psychological-intervention-for-gynaecological-cancer-patients-admitted-for-surgery-preliminary-data
#4
Paola Arnaboldi, Serena Oliveri, Valeria Vadilonga, Luigi Santoro, Angelo Maggioni, Gabriella Pravettoni
OBJECTIVE: To investigate patients' satisfaction and perceived utility for psychological consultations delivered by clinical psychologists in a sample of gynaecological cancer patients hospitalised for surgery. METHODS: A total of 51 gynaecological cancer patients who scored higher than four on the distress thermometer (DT) were proposed and received a psychological consultation during hospitalisation for surgery. After six months from discharge, patients were asked, during a telephone interview, to rate their level of distress post-treatment, their perceived satisfaction, and usefulness of the psychological intervention received...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28275390/dual-role-of-inflammatory-mediators-in-cancer
#5
REVIEW
T G Shrihari
Inflammation is the body's response to noxious stimuli such as infectious, physiological or chemical agents, it releases various inflammatory mediators via immune cells such as neutrophils, macrophages, and lymphocytes. These inflammatory mediators are growth factors, chemokines, and cytokines. Reactive oxygen species (ROS) and nitrogen species (RNS) activate transcriptional factors (NF-KB, STAT-3) and bring about cellular proliferation, genomic instability, angiogenesis, resistance to apoptosis, invasion, and metastasis...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28275389/cd19-cd56-myeloma-arising-in-a-patient-who-failed-two-courses-of-immunosupressive-therapy-for-aplastic-anaemia
#6
Nigel P Murray, M Amparo Ruiz, G Maximiliano Miranda
Patients diagnosed with severe aplastic anaemia and without a compatible bone marrow transplant donor are treated with immunosuppressive therapy. These patients are found with time to develop a clonal disease such as myelodysplasia or paroxysmal nocturnal haemoglobinuria. However, the development of plasma cell dyscrasias is rare. We report the case here of a patient treated with immunosuppressive therapy who went on to develop myeloma 11 months after being diagnosed with severe aplastic anaemia. We include here a review of the literature...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28275388/highlights-of-the-twelfth-annual-meeting-of-the-national-cancer-research-institute-ncri-6-9-november-2016-liverpool-uk
#7
Linda Cairns, Audrey Nailor, Lisa Whittaker
The annual meeting of the National Cancer Research Institute (NCRI), held in Liverpool, UK, is a multidisciplinary conference. The meeting generally outlines research trends for the coming year and is aimed at cancer professionals at every level. The most important themes discussed for this conference was that of cancer stem cells. Alongside once again prominence was given to topics of cancer evolution and the role of social prevention programmes like previous years.
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28194230/what-are-the-personal-and-professional-characteristics-that-distinguish-the-researchers-who-publish-in-high-and-low-impact-journals-a-multi-national-web-based-survey
#8
Carlos Eduardo Paiva, Raphael L C Araujo, Bianca Sakamoto Ribeiro Paiva, Cristiano de Pádua Souza, Flavio Mavignier Cárcano, Marina Moreira Costa, Sérgio Vicente Serrano, João Paulo Nogueira Lima
PURPOSE: This study identifies the personal and professional profiles of researchers with a greater potential to publish high-impact academic articles. METHOD: The study involved conducting an international survey of journal authors using a web-based questionnaire. The survey examined personal characteristics, funding, and the perceived barriers of research quality, work-life balance, and satisfaction and motivation in relation to career. The processes of manuscript writing and journal publication were measured using an online questionnaire that was developed for this study...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28194229/circulating-and-tissue-biomarkers-in-early-stage-non-small-cell-lung-cancer
#9
Caterina Fumagalli, Fabrizio Bianchi, Paola Rafaniello Raviele, Davide Vacirca, Giovanni Bertalot, Cristiano Rampinelli, Matteo Lazzeroni, Bernardo Bonanni, Giulia Veronesi, Nicola Fusco, Massimo Barberis, Elena Guerini-Rocco
OBJECTIVE: We sought to characterise circulating and tissue tumour biomarkers of patients who developed early-stage non-small cell lung cancer (NSCLC) during long-term follow-up of a chemoprevention trial (NCT00321893). MATERIALS AND METHODS: Blood and sputum samples were collected from 202 high-risk asymptomatic individuals with CT-detected stable lung nodules. Real-time PCR was performed on plasma to quantify free circulating DNA. Baseline serum was investigated with a previously validated test based on 13 circulating miRNAs (miR-Test)...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28194228/guidelines-for-the-management-of-neuroendocrine-tumours-by-the-brazilian-gastrointestinal-tumour-group
#10
Rachel P Riechelmann, Rui F Weschenfelder, Frederico P Costa, Aline Chaves Andrade, Alessandro Bersch Osvaldt, Ana Rosa P Quidute, Allan Dos Santos, Ana Amélia O Hoff, Brenda Gumz, Carlos Buchpiguel, Bruno S Vilhena Pereira, Delmar Muniz Lourenço Junior, Duilio Reis da Rocha Filho, Eduardo Antunes Fonseca, Eduardo Linhares Riello Mello, Fabio Ferrari Makdissi, Fabio Luiz Waechter, Francisco Cesar Carnevale, George B Coura-Filho, Gustavo Andrade de Paulo, Gustavo Colagiovanni Girotto, João Evangelista Bezerra Neto, João Glasberg, Jose Claudio Casali-da-Rocha, Juliana Florinda M Rego, Luciana Rodrigues de Meirelles, Ludhmila Hajjar, Marcos Menezes, Marcello D Bronstein, Marcelo Tatit Sapienza, Maria Candida Barisson Villares Fragoso, Maria Adelaide Albergaria Pereira, Milton Barros, Nora Manoukian Forones, Paulo Cezar Galvão do Amaral, Raphael Salles Scortegagna de Medeiros, Raphael L C Araujo, Regis Otaviano França Bezerra, Renata D'Alpino Peixoto, Samuel Aguiar, Ulysses Ribeiro, Tulio Pfiffer, Paulo M Hoff, Anelisa K Coutinho
Neuroendocrine tumours are a heterogeneous group of diseases with a significant variety of diagnostic tests and treatment modalities. Guidelines were developed by North American and European groups to recommend their best management. However, local particularities and relativisms found worldwide led us to create Brazilian guidelines. Our consensus considered the best feasible strategies in an environment involving more limited resources. We believe that our recommendations may be extended to other countries with similar economic standards...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28194227/bone-metastasis-risk-factors-in-breast-cancer
#11
REVIEW
Catarina Pulido, Inês Vendrell, Arlindo R Ferreira, Sandra Casimiro, André Mansinho, Irina Alho, Luís Costa
Bone is the single most frequent site for bone metastasis in breast cancer patients. Patients with bone-only metastasis have a fairly good prognosis when compared with patients with visceral disease. Nevertheless, cancer-induced bone disease carries an important risk of developing skeletal related events that impact quality of life (QoL). It is therefore particularly important to stratify patients according to their risk of developing bone metastasis. In this context, several risk factors have been studied, including demographic, clinicopathological, genetic, and metabolic factors...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28144288/gastric-cancer-and-related-epigenetic-alterations
#12
REVIEW
Trupti N Patel, Soumyadipta Roy, Revathi Ravi
Gastric cancer, a malignant and highly proliferative condition, has significantly affected a large population around the globe and is known to be caused by various factors including genetic, epigenetic, and environmental influences. Though the global trend of these cancers is declining, an increase in its frequency is still a threat because of changing lifestyles and dietary habits. However, genetic and epigenetic alterations related to gastric cancers also have an equivalent contribution towards carcinogenic development...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28144287/estimation-of-life-expectancy-of-patients-diagnosed-with-the-most-common-cancers-in-the-valparaiso-region-chile
#13
C Taramasco, K Figueroa, Y Lazo, J Demongeot
BACKGROUND: The 1000s of people who die from cancer each year have become one of the leading causes of death among the Chilean population, placing it as the second cause of death in the region of Valparaiso between 1997 and 2003. Statistics have provided different measures regarding the life expectancy of cancer patients which have resulted in being useful to establish courses of action for prevention and treatment plans to follow. METHODS: Data was extracted from the cancer module of the Epidemiology Assistance System (SADEPI for its initials in Spanish) which stores information about cancer cases in the provinces of Valparaiso and Petorca...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28144286/study-of-clinical-haematological-and-cytogenetic-profile-of-patients-with-acute-erythroid-leukaemia
#14
Jacob Abraham Linu, Ms Namratha Udupa, D S Madhumathi, K C Lakshmaiah, K Govind Babu, D Lokanatha, Mc Suresh Babu, K N Lokesh, L K Rajeev, A H Rudresha
BACKGROUND: Acute erythroid leukaemia (AEL) is a rare subtype of acute myeloid leukaemia (AML), constituting <5% of all the cases of AML. The World Health Organization (WHO) in 2001 classified AEL into two types: (1) erythroid/myeloid leukaemia which required ≥50% erythroid precursors with ≥20% of the non-erythroid cells to be myeloid blasts and (2) pure erythroleukemia (pEL) with ≥80% erythroblasts. The WHO 2008 classification kept these subcategories, but made erythroleukemia a diagnosis of exclusion...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28144285/the-presence-of-primary-circulating-prostate-cells-is-associated-with-upgrading-and-upstaging-in-patients-eligible-for-active-surveillance
#15
Nigel P Murray, Eduardo Reyes, Cynthia Fuentealba, Socrates Aedo, Omar Jacob
Active surveillance (AS) is a considered treatment option for men with low or very low-risk prostate cancer. However, on repeat biopsy some 25% were upgraded and recommended for active treatment. We compare the presence or absence of primary circulating prostate cells (CPCs) with the clinical pathological findings after radical prostatectomy in men fulfilling the criteria for active surveillance and the risk of reclassification for active observation (AO). METHODS AND PATIENTS: A single centre observational study was done involving 102 men who fulfilled the Epstein criteria for AS and underwent radical prostatectomy as mono-therapy for prostate cancer...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28144284/balancing-health-care-needs-in-a-changing-context-nursing-highlights-from-the-2016-european-oncology-nursing-society-congress-eons10-17-18-october-2016-dublin-ireland
#16
Danuta Lichosik, Rosario Caruso
European cancer nurses have to face many challenges as a result of the rapidly changing economic and political context in which balancing health care needs has become strategic for healthcare delivery. Currently, cancer nurses must overcome many obstacles arising from clinical, organisational, and educational issues. Within this scenario, the European Oncology Nursing Society (EONS) shaped its tenth congress programme to boost discussion and reflections, to share experiences and research, and to see how cancer nurses try to anticipate and embrace changes...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28144283/the-impact-of-the-eu-general-data-protection-regulation-on-scientific-research
#17
Gauthier Chassang
The use of personal data is critical to ensure quality and reliability in scientific research. The new Regulation [European Union (EU)] 2016/679 of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data [general data protection regulation (GDPR)], repealing Directive 95/46/EC, strengthens and harmonises the rules for protecting individuals' privacy rights and freedoms within and, under certain conditions, outside the EU territory...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28105079/hepatocellular-carcinoma-in-identical-twins-in-chile-case-report
#18
Christian Caglevic, Shirley Silva, Mauricio Mahave, Javiera Torres, Christian Rolfo, Jorge Gallardo, Paula Carrasco
Liver cancer is the second leading cause of cancer death worldwide, with hepatocellular carcinoma (HCC) being the most common type of primary malignant liver tumour, with a typically poor prognosis, growing incidence and a well-documented relationship with chronic inflammation factors of the liver tissue. Despite the fact that family medical history has been identified as a risk factor for the development of HCC, its significance in terms of etiopathogenesis and prognosis is not well documented. With a view to contributing to this discussion, we will report the clinical case of two identical twins with HCC, both diagnosed within a short period of time, by providing relevant clinical data, and relating this to other medical literature reports that could contribute to a deeper understanding of this illness...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/28105078/the-current-situation-for-gastric-cancer-in-chile
#19
REVIEW
Christian Caglevic, Shirley Silva, Mauricio Mahave, Christian Rolfo, Jorge Gallardo
Gastric cancer is a neoplasm with a high incidence and mortality rate in Chile where more than 3000 people die every year from this type of cancer. This study shows the clinical and epidemiological considerations of this disease, information about translational research on this pathology in Chile, the contribution of Chilean doctors to the development of gastric cancer management awareness and the general situation of gastric cancer in Chile.
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/28105077/why-a-d2-gastrectomy-plus-adjuvant-chemotherapy-is-insufficient-in-locally-advanced-gastric-cancer
#20
REVIEW
Z Sebastián Solé, Francisco E Larsen, Claudio V Solé
This review discusses all the important published evidence regarding adjuvant treatments in locally advanced gastric cancer. In this process it revealed facts that demonstrate the superiority of radiotherapy and concomitant chemotherapy to chemotherapy alone. Some outstanding work that has not yet been published is also discussed.
2016: Ecancermedicalscience
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