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Ecancermedicalscience

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https://www.readbyqxmd.com/read/30174725/surgery-for-brca-tp53-and-palb2-a-literature-review
#1
REVIEW
Chin-Vern Song, Soo-Hwang Teo, Nur Aishah Taib, Cheng-Har Yip
Introduction: The presence of a deleterious mutation, most commonly a BRCA mutation, has a tremendous impact on the management of breast cancer. We review the surgical management of BRCA mutation carriers, and two other potentially high-risk mutations, TP53 and PALB2. Methodology: A search was done on PubMed, limited to reviews and the English language only. The search terms used were ' BRCA ' or ' PALB2 ' or ' TP53 ' and 'surgery'. Fifteen articles were identified by searching and one article was obtained from other sources...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/30174724/quick-and-sustained-clinical-response-to-mek-inhibitor-i-in-a-nf1-patient-with-neurofibromas
#2
Honoré Papalia, Frédérique Audic, Gabriel Revon Rivière, Arnauld Verschuur, Nicolas André
Neurofibromatosis 1 (NF1) is an autosomal dominant tumour predisposition disorder with a birth incidence of about 1 in 2,700 and prevalence of 1 in 4,560. The NF1 gene codes for an ubiquitous protein: neurofibromin. Neurofibromin interacts with the proto-oncogene RAS to suppress tumour formation. Individuals with germline inactivation of the NF1 gene have a propensity to develop both benign and malignant tumours. We report the case of a 12-year-old child with NF1, diagnosed at the age of 15 months, for whom the clinical course has been marked by the appearance of multiple cutaneous and paraspinal neurofibromas responsible for impaired walking, motor deficiency and pain...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/30174723/pancreatoblastoma-in-a-paediatric-patient-anatomo-pathological-aspects-of-a-case-with-multiple-hepatic-metastases
#3
Gabriel Cao, Julián Mendez, Daniel Navacchia
Pancreatoblastoma is a rare paediatric malignant neoplasm. The treatment of choice is complete surgical resection. However, it is often unresectable due to its large size, local infiltration or distant metastasis. Since the condition is rare, there is currently no standard treatment regimen. We outline the case of a 4-year-old child who presented with abdominal pain and distention, together with an enlarged liver and elevated serum α-fetoprotein levels. Imaging studies showed the presence of an abnormal pancreatic tumour and multiple nodular lesions in the liver, the biopsies from which led to a diagnosis of pancreatoblastoma...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/30174722/a-cancer-mimicking-diagnosis-of-peritoneal-carcinosis-report-of-a-case-of-abdominal-non-tuberculous-mycobacterial-infection
#4
Francesca De Piano, Filippo Savoldi, Francesca Ruju, Mariacristina Ghioni, Vanna Zanagnolo, Stefania Rizzo
Abdominal non-tuberculous mycobacterial infection is a rare condition in healthy patients. When it occurs, it leads to the appearance of typical findings of peritoneal involvement, such as thickening of the peritoneal leaflets and the omentum, ascites and enlargement of lymph nodes and of mesenteric nodules. These findings may be misdiagnosed as tumour peritoneal implants. In case of spontaneous regression of the peritoneal involvement and ascites, as well as in the absence of malignancy, the suspicion of infectious disease, including abdominal nontuberculous mycobacterial infection, should be considered...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/30174721/lung-cancer-patients-have-the-highest-malignancy-associated-suicide-rate-in-usa-a-population-based-analysis
#5
REVIEW
Mohamed Rahouma, Mohamed Kamel, Ahmed Abouarab, Ihab Eldessouki, Abu Nasar, Sebron Harrison, Benjamin Lee, Eugene Shostak, John Morris, Brendon Stiles, Nasser K Altorki, Jeffrey L Port
Purpose: Previous studies have reported that psychological and social distresses associated with a cancer diagnosis have led to an increase in suicides compared to the general population. We sought to explore lung cancer-associated suicide rates in a large national database compared to the general population, and to the three most prevalent non-skin cancers [breast, prostate and colorectal cancer (CRC)]. Methods: The Surveillance, Epidemiology and End Results (SEER) database (1973-2013) was retrospectively reviewed to identify cancer-associated suicide deaths in all cancers combined, as well as for each of lung, prostate, breast or CRCs...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/30174720/recurrent-dermatofibrosarcoma-protuberans-challenging-a-surgeon-s-dexterity-for-the-tricky-margins
#6
Deepak Kumar Diwakar, Nikita Wadhwani, Shivani Paruthi
Soft tissue tumours represent 0.2%-1% of all breast malignancies. [Al Tarakji M, Toro A, and Di Carlo I, et al (2015) Unusual presentation of dermatofibrosarcoma protuberans in a male patient's breast: a case report and review of the literature World J Surg Oncol 13 158 https://doi.org/10.1186/s12957-015-0562-1]. Out of those, Dermatofibrosarcoma protuberans (DFSP) of the breast is extremely rare, especially in men with only six cases, including this case, reported so far. We report a case of recurrent DFSP in a 35-year-old male after a latency of 8 years in the region of previous surgical scar...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/30174719/the-understanding-of-healthcare-workers-on-the-content-of-palliative-care-policy-in-shesilweni-swaziland-a-qualitative-study
#7
EDITORIAL
Teluleko Nhlonipho Maseko, Collin Pfaff, Aziza Mwisongo
We undertook a qualitative study design to explore the understanding of healthcare workers of the content of the palliative care policy in Swaziland. A total of 17 health workers participated in this study. The study showed that there was a lack of knowledge about palliative care, confusion as to where palliative care should be offered and by whom and the role of providing medication as a part of palliative care. Interestingly, the health workers mentioned the importance of different actors, the importance of teamwork and some perceived successes of palliative care implementation...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/30174718/two-cases-of-white-globe-appearance-in-non-cancerous-stomach
#8
Masaya Iwamuro, Takehiro Tanaka, Hiroyuki Sakae, Yasushi Yamasaki, Hiromitsu Kanzaki, Seiji Kawano, Yoshiro Kawahara, Hiroyuki Okada
In this report, we describe two patients with white globe appearance in the non-cancerous stomach. The patient in Case 1 was an 82-year-old Japanese man who had been taking vonoprazan, dimethicone, acotiamide, sitagliptin, candesartan, dutasteride, etizolam and zolpidem. The patient in Case 2 was a 74-year-old Japanese woman who had been taking esomeprazole, rebamipide, sitagliptin, candesartan, ezetimibe, mirabegron, levocetirizine, zolpidem and lactobacillus preparation. In both cases, endoscopy revealed multiple white spots in the stomach...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/30093919/breath-biopsy-for-early-detection-and-precision-medicine-in-cancer
#9
EDITORIAL
Marc van der Schee, Hazel Pinheiro, Edoardo Gaude
Breath biopsy enables the non-invasive collection and analysis of volatile organic compounds (VOCs) in exhaled breath, providing valuable information about disease processes occurring in the body. Metabolic changes occur in cancer cells at the earliest stages of disease. We discuss progress in the use of breath biopsy for discovery of breath-based biomarkers for early detection of cancer, and potential applications for breath biopsy in enabling precision medicine in cancer.
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/30093918/accountability-in-the-nhs-the-impact-on-cancer-care
#10
EDITORIAL
Aislinn Macklin-Doherty
Accountability of service delivery is becoming increasingly complex and never has this been more apparent than in the field of Oncology. Cancer care has an unrivalled level of complexity not only in the heterogeneity of management of the disease itself but increasingly in the myriad of service providers, specialities, policymakers and regulatory bodies overseeing its delivery. The stepwise series of changes to NHS structures over recent decades has had an enormous impact on our ability to answer key questions which lie at the heart of accountability: who is making the key decisions about changes to cancer care delivery? What are these reforms achieving? How can they be influenced? It is only through clear and transparent decision-making that we may have any hope of implementing, monitoring and influencing the effects of evidence-based change...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/30093917/survival-probabilities-and-trends-for-lip-oral-cavity-and-oropharynx-cancers-in-northern-portugal-in-the-period-2000-2009
#11
Luís Silva Monteiro, Luís Antunes, Lúcio Lara Santos, Maria José Bento, Saman Warnakulasuriya
Background: Oral cancer represents a serious public health problem worldwide. Our aim was to analyse the survival probabilities and trends of patients presenting with lip, oral cavity and oropharynx cancers, who were residents in the north of Portugal. Methods: Using cancer-registry data, we conducted a population-based study of lip, oral cavity and oropharynx cancers diagnosed in the period 2000-2009, among residents in the north of Portugal. Net survival was estimated using the Pohar-Perme estimator...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/30093916/nurse-led-active-surveillance-for-prostate-cancer-is-safe-effective-and-associated-with-high-rates-of-patient-satisfaction-results-of-an-audit-in-the-east-of-england
#12
Estelle Martin, Satyendra Persaud, John Corr, Rowan Casey, Rajiv Pillai
Introduction: Active surveillance (AS) is an option in the management of men with low-stage, low-risk prostate cancer. These patients, who often require prolonged follow-up, can put a strain on outpatient resources. Nurses are ideally placed to develop advanced roles to help meet this increased demand-a model we have utilised since 2014. We set about to comprehensively evaluate our nurse-led AS (NLAS) programme. Patients and methods: An audit of patient notes was carried out to assess compliance with trust and national guidelines...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/30079115/mhealth-and-telemedicine-apps-in-search-of-a-common-regulation
#13
Chiara Crico, Chiara Renzi, Norbert Graf, Alena Buyx, Haridimos Kondylakis, Lefteris Koumakis, Gabriella Pravettoni
Developments in information and communication technology have changed the way healthcare processes are experienced by both patients and healthcare professionals: more and more services are now available through computers and mobile devices. Smartphones are becoming useful tools for managing one's health, and today, there are many available apps meant to increase self-management, empowerment and quality of life. However, there are concerns about the implications of using mHealth and apps: data protection issues, concerns about sharing information online, and the patients' capacity for discerning effective and valid apps from useless ones...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/30079114/development-of-an-ehealth-tool-for-cancer-patients-monitoring-psycho-emotional-aspects-with-the-family-resilience-fare-questionnaire
#14
REVIEW
Flavia Faccio, Chiara Renzi, Chiara Crico, Eleni Kazantzaki, Haridimos Kondylakis, Lefteris Koumakis, Kostas Marias, Gabriella Pravettoni
In the last decade, clinicians have started to shift from an individualistic perspective of the patient towards family-centred models of care, due to the increasing evidence from research and clinical practice of the crucial role of significant others in determining the patient's adjustment to cancer disease and management. eHealth tools can be considered a means to compensate the services gap and support outpatient care flows. Within the works of the European H2020 iManageCancer project, a review of the literature in the field of family resilience was conducted, in order to determine how to monitor the patient and his/her family's resilience through an eHealth platform...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/30079113/personal-health-information-recommender-implementing-a-tool-for-the-empowerment-of-cancer-patients
#15
Galatia Iatraki, Haridimos Kondylakis, Lefteris Koumakis, Maria Chatzimina, Eleni Kazantzaki, Kostas Marias, Manolis Tsiknakis
Nowadays, patients have a wealth of information available on the Internet. Despite the potential benefits of Internet health information seeking, several concerns have been raised about the quality of information and about the patient's capability to evaluate medical information and to relate it to their own disease and treatment. As such, novel tools are required to effectively guide patients and provide high-quality medical information in an intelligent and personalised manner. With this aim, this paper presents the Personal Health Information Recommender (PHIR), a system to empower patients by enabling them to search in a high-quality document repository selected by experts, avoiding the information overload of the Internet...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/30079112/the-role-of-serious-games-in-the-imanagecancer-project
#16
Stefan Hoffmann, Stephen Wilson
Within the iManageCancer project, two serious games were developed, one for adults and one for children and adolescents. The adult's game was developed by the University of Bedfordshire (UK), the kid's game by Promotion Software GmbH (Germany). The aim was to support adult and young cancer patients with serious games to manage the impact of the disease on their psychological status, such as negative emotions, anxiety or depression, and motivate them to stay positive and to participate in social life [Patterson and Garwick (1994) Ann Behav Med 16 131-142; Brennan et al ...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/30079111/myhealthavatar-lifestyle-management-support-for-cancer-patients
#17
Xu Zhang, Zhikun Deng, Farzad Parvinzamir, Feng Dong
MyHealthAvatar (MHA) is built on the latest information and communications technology with the aim of collecting lifestyle and health data to promote citizen's wellbeing. According to the collected data, MHA offers visual analytics of lifestyle data, contributes to individualised disease prediction and prevention, and supports healthy lifestyles and independent living. The iManageCancer project aims to empower patients and strengthen self-management in cancer diseases. Therefore, MHA has contributed to the iManageCancer scenario and provides functionality to the iManageCancer platform in terms of its support of lifestyle management of cancer patients by providing them with services to help their cancer management...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/30079110/imanagemyhealth-and-isupportmypatients-mobile-decision-support-and-health-management-apps-for-cancer-patients-and-their-doctors
#18
Fatima Schera, Michael Schäfer, Anca Bucur, Jasper van Leeuwen, Eric Herve Ngantchjon, Norbert Graf, Haridimos Kondylakis, Lefteris Koumakis, Kostas Marias, Stephan Kiefer
Clinical decision support systems can play a crucial role in healthcare delivery as they promise to improve health outcomes and patient safety, reduce medical errors and costs and contribute to patient satisfaction. Used in an optimal way, they increase the quality of healthcare by proposing the right information and intervention to the right person at the right time in the healthcare delivery process. This paper reports on a specific approach to integrated clinical decision support and patient guidance in the cancer domain as proposed by the H2020 iManageCancer project...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/30079109/a-prospective-survey-of-comprehensive-score-for-financial-toxicity-in-japanese-cancer-patients-report-on-a-pilot-study
#19
Kazunori Honda, Bishal Gyawali, Masashi Ando, Keiji Sugiyama, Seiichiro Mitani, Toshiki Masuishi, Yukiya Narita, Hiroya Taniguchi, Shigenori Kadowaki, Takashi Ura, Kei Muro
Background: Financial toxicity (FT) has a negative impact on the quality of life and survival of patients with cancer. The comprehensive score for FT (COST) questionnaire is a tool to measure FT which has already been validated in patients with cancer in the United States. However, the feasibility and validity of assessing FT using the COST questionnaire have not been established in non-US healthcare settings, including that in Japan. Methods: This is a prospective pilot survey to ascertain the feasibility of using the COST questionnaire to evaluate FT in Japanese patients with advanced solid cancer who had been receiving chemotherapy for at least 2 months...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/30079108/an-unusual-case-of-a-glottic-carcinoma-metastasis-to-the-tracheal-lumen
#20
Sarantis Blioskas, Peter Karkos, Iordanis Konstantinidis, Kyriakos Chatzopoulos, George Psillas, Prodromos Chytiroglou, Konstantinos Markou
Various mechanisms such as second primary lesion, tumour seeding or lymphogenous and haematogenous metastasis could be proposed to explain the nature of dual malignant lesions. We report the case of a glottic laryngeal carcinoma combined with a secondary endotracheal tumour. Following the imaging modalities, the patient underwent total laryngectomy and wide excision of the trachea. Histopathology ultimately established that the tracheal lesion was a metastatic tumour secondary to regional lymphatic spread of the glottic tumour...
2018: Ecancermedicalscience
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