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Ecancermedicalscience

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https://www.readbyqxmd.com/read/29104615/can-e-learning-help-you-to-connect-compassionately-commentary-on-a-palliative-care-e-learning-resource-for-india
#1
EDITORIAL
Soumitra Shankar Datta, Sanjit Agrawal
e-learning resources need to be customised to the audience and learners to make them culturally relevant. The 'Palliative care e-learning resource for health care professionals in India' has been developed by the Karunashraya Hospice, Bengaluru in collaboration with the Cardiff Palliative Care Education Team, Wales to address the training needs of professionals in India. The resource, comprising over 20 modules, integrates psychological, social and medical care for patients requiring palliative care for cancer and other diseases...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29104614/proton-radiobiology-and-its-clinical-implications
#2
REVIEW
Bleddyn Jones
Denser ionisation clustering and complex DNA damage in proton Bragg peaks far exceeds that seen with conventional X-rays. This results in more efficient cell sterilisation, quantified by the relative biological effectiveness (RBE). Currently, a 1.1 RBE is used to determine the clinical proton doses by dividing the usual X-rays dose by this amount. This number, derived from short-term experiments, has been criticised as being irrelevant to late normal tissue (NT) effects following radiotherapy and included many control irradiations using lower voltage X-rays (with elevated RBE values) than those used in the clinic...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29104613/impact-of-exon-19-versus-exon-21-egfr-activating-mutation-on-outcomes-with-upfront-pemetrexed-carboplatin-chemotherapy
#3
Vanita Noronha, Vijay Patil, Amit Joshi, Anuradha Chougule, Atanu Bhattacharjee, Rajiv Kumar, Sucheta More, Supriya Goud, Ashay Karpe, Anant Ramaswamy, Nikhil Pande, Arun Chandrasekharan, Alok Goel, Vikas Talreja, Abhishek Mahajan, Amit Janu, Nilendu Purandare, Kumar Prabhash
Background: EGFR mutation subtype is a recognised factor impacting outcomes of patients receiving oral tyrosine kinase inhibitors (TKIs) in non-small-cell lung cancer (NSCLC). Evidence for the effect of this factor on outcomes in patients receiving pemetrexed is limited. Methods: We completed a study comparing pemetrexed-platinum combination versus oral TKI in EGFR mutation-positive patients in lung cancer. We analysed the impact of EGFR mutation subtype, specifically, exon 19 and 21 on the PFS and OS of patients treated with pemetrexed (500 mg/m(2) on day 1) and carboplatin (AUC 5 on day 1) as first-line therapy...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29104612/laparoscopic-liver-resection-in-metastatic-colorectal-cancer-treatment-comparison-with-long-term-results-using-the-conventional-approach
#4
Rafael José Maurette, Marcos García Ejarque, Matías Mihura, Mariano Bregante, Diego Bogetti, Daniel Pirchi
Background: Laparoscopic liver resections (LLRs) have been shown to be both feasible and safe. However, no randomised control studies have been performed to date comparing results with those of the open surgery approach. Main aim: To analyse LLR long-term results and compare them with a similar group of open resections in patients with colorectal carcinoma liver metastasis (CRCLM). Methods: Retrospective study on a prospective database. All patients with anatomopathological diagnosis of CRCLM resected between July 2007 and July 2015...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29104611/frozen-section-evaluation-of-sentinel-lymph-nodes-in-breast-carcinoma-a-retrospective-analysis
#5
Leonardo Russo, Luis Betancourt, Gabriel Romero, Alí Godoy, Laura Bergamo, Rafael Delgado, Ángela Ruiz, Marianna Gutiérrez, Eduardo Salas, Maria Puzzi
Objective: To determine the false-negative rate, sensitivity, and diagnostic accuracy of the frozen section analysis of the sentinel lymph node (SLN) biopsy in early-stage breast cancer compared to the definitive section and to identify the factors that could be associated with the appearance of false-negative cases. Secondarily, to evaluate the pathological results of cases submitted to completion axillary lymph node dissection (ALND) for positive SLN. Methods: We performed a five-year review of cases (2011-2015), including patients with early-stage breast cancer undergoing SLN biopsy, with frozen section evaluation and subsequent definitive pathological analysis...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29104610/functional-pancreatic-neuroendocrine-tumour-causing-cushing-s-syndrome-the-effect-of-chemotherapy-on-clinical-symptoms
#6
Paulo Henrique do Amor Divino, Katia Regina Marchetti, Madson Q Almeida, Rachel P Riechelmann
Background: Neuroendocrine tumours (NETs) are a heterogeneous group of diseases that can originate from any part of the gastrointestinal tract, bronchi, thyroid and pancreas. These tumours may be functioning or not depending on their ability to produce active substances, such as adrenocorticotrophic hormone (ACTH). ACTH-producing pancreatic neuroendocrine tumours are rare, with limited data about effective antitumor therapies. Case Report: A 58-year-old man with a history of type-2 diabetes mellitus and arterial hypertension was diagnosed with Cushing's syndrome (CS) secondary to an ACTH ectopic production from a well-differentiated neuroendocrine tumour of the pancreas metastatic to the liver...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29104609/a-discrete-transition-zone-between-cuticle-and-cortex-layers-of-a-human-hair-fibre-changes-observed-in-the-presence-of-breast-cancer
#7
Donald Lyman, Paula Gerstmann
Attenuated total reflection Fourier transform infrared (ATR-FT-IR) spectroscopy of hair fibres shows a discrete transition zone (DTZ) between the hard protective cuticle layer and the softer elongated cortical cells of the cortex. The DTZ is composed of flattened orthocortical cells located on the outer perimeter of the cortex and appears to range in thickness between 2 and 3.6 μm. The inner surface of the DTZ, adjacent to the elongated cortical cells that make up the core of the hair fibre, is irregular. ATR-FT-IR analyses of these flattened orthocortical cells indicate major changes in the molecular structure of keratins found in this transition zone...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29062389/use-of-peg-asparaginase-in-monomorphic-epitheliotropic-intestinal-t-cell-lymphoma-a-disease-with-diagnostic-and-therapeutic-challenges
#8
Cesar Gentille, Qian Qin, Andreia Barbieri, Pingali Sai Ravi, Swaminathan Iyer
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), previously known as enteropathy associated T-cell lymphoma (EATL) type II, is a rare haematological malignancy with a difficult and delayed diagnosis. Symptoms can include abdominal pain, weight loss, and chronic diarrhoea. However, most patients are only diagnosed after complications, such as perforation or obstruction, have developed. There is no standard treatment for MEITL; most accepted regimens consist of surgical resection and anthracycline-based chemotherapy...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29062388/highlights-from-the-win-2017-symposium-26-27-june-2017-paris-france-expediting-global-innovation-in-precision-cancer-medicine
#9
Will Davies
The Worldwide Innovative Networking (WIN) symposium brings together representatives from academic institutions, pharmaceutical partners, technology companies and charitable organisations from across the globe for an annual summit, discussing ongoing research and the latest developments in precision medicine. Now, in its seventh year, the aims of the WIN consortium's annual meeting, to foster communication and collaboration between members and deliver clinical trial results that improve the care and outcomes of patients are presented in open dialogue to encourage debate and discussion...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29062387/limitations-of-workers-diagnosed-with-cancer-evaluated-with-work-role-functioning-questionnaire-br
#10
Cristiane H Gallasch, Neusa Mc Alexandre, Sergio Cb Esteves, Helena F Gomes, Elaine Cl da Rocha, Patricia Cp Baptista
The main subject of the current study is to look into the limitations found in individuals diagnosed with cancer, considered a public health problem, especially in developing countries where the impact of this disease is expected to account for 80% of 20 million new cases estimated worldwide by 2025. For some patients undergoing treatment, continuing to be professionally active is challenging especially considering that work fosters a purpose in life, a sense of contribution, distraction, and self-esteem, which aids in physical, cognitive, emotional, and interpersonal recovery...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29062386/proteins-regulating-the-intercellular-transfer-and-function-of-p-glycoprotein-in-multidrug-resistant-cancer
#11
REVIEW
Deep Pokharel, Ariane Roseblade, Vici Oenarto, Jamie F Lu, Mary Bebawy
Chemotherapy is an essential part of anticancer treatment. However, the overexpression of P-glycoprotein (P-gp) and the subsequent emergence of multidrug resistance (MDR) hampers successful treatment clinically. P-gp is a multidrug efflux transporter that functions to protect cells from xenobiotics by exporting them out from the plasma membrane to the extracellular space. P-gp inhibitors have been developed in an attempt to overcome P-gp-mediated MDR; however, lack of specificity and dose limiting toxicity have limited their effectiveness clinically...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28955404/responsible-pricing-in-value-based-assessment-of-cancer-drugs-real-world-data-are-an-inevitable-addition-to-select-meaningful-new-cancer-treatments
#12
EDITORIAL
Wim van Harten, Maarten J IJzerman
Recently, NICE was given the task of governing the Cancer Drug Fund (CDF) in the UK as the latter was criticized for allowing too many insufficiently tested drugs to be covered [1, 2]. The CDF was initiated in 2012, but immediately received criticism from several health economists because of the rather strict coverage criteria that are commonly used by NICE for most other health services in the NHS. This led to questions about the use of different reimbursement criteria (why have a different fund otherwise?) for expensive cancer drugs...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28955403/expression-of-ercc1-bcl-2-lin28a-and-ki-67-as-biomarkers-of-response-to-first-line-platinum-based-chemotherapy-in-patients-with-high-grade-extrapulmonary-neuroendocrine-carcinomas-or-small-cell-lung-cancer
#13
Juliana Florinda de M Rêgo, Raphael Salles Scortegagna de Medeiros, Maria Ignez Braghiroli, Breno Galvão, João Evangelista Bezerra Neto, Rodrigo Ramella Munhoz, Juliana Guerra, Suely Nonogaki, Lidia Kimura, Tulio Eduardo Pfiffer, Gilberto de Castro, Paulo Marcelo Hoff, Duilio Rocha Filho, Frederico Perego Costa, Rachel P Riechelmann
BACKGROUND: Small cell lung cancer (SCLC) and high-grade extrapulmonary neuroendocrine carcinomas (EPNEC) share similar histopathological features and treatment, but outcomes may differ. We evaluated in our study the expression of biomarkers associated with response rate (RR) to chemotherapy and overall survival (OS) for these entities. MATERIALS AND METHODS: This is a multicentre retrospective analysis of advanced EPNEC and SCLC patients treated with platinum-based chemotherapy...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28955402/%C3%AF-unusual-case-of-splenic-sarcoidosis-without-morphological-lesions-detected-by-pet-ct-in-a-patient-with-breast-cancer-functional-imaging-between-pitfalls-and-therapeutic-guide
#14
Gaetano Paone, Simona Di Lascio, Andrea Azzola, Luca Mazzucchelli, Olivia Pagani
A 60-year-old woman under treatment with letrozole for metastatic breast cancer underwent (18)F-FDG PET-CT for restaging. A new widespread intense splenic FDG uptake without nodular lesions and multiple FDG-avid mediastinal and abdominal nodes were observed. Based on these findings, a nodal and transbronchial lung biopsy was performed. Histological results were compatible with sarcoidosis. The patient began steroid treatment and 6 weeks after a PET-CT showed normalisation of both splenic and nodal uptake. In our case, (18)F-FDG PET-CT has been useful in detecting a rare case of splenic sarcoidosis without typical nodular lesions on CT images, impacting the patient's treatment and prognosis...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28955401/the-cost-of-cancer-treatment-in-portugal
#15
José Machado Lopes, Francisco Rocha Gonçalves, Marina Borges, Patrícia Redondo, José Laranja-Pontes
INTRODUCTION: Cancer is the second most common cause of death in Portugal, with 24.3% of these deaths caused by malignant neoplasms. The strong impact on lost productivity and rising treatment costs make cancer a priority. In order to understand, compare, and control costs by promoting transparency in the health system, it is vital to analyse the cost of oncological diseases. This study aims to estimate the economic burden associated with the treatment of cancer in Portugal by calculating the direct medical costs...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28955400/systemic-anticancer-therapy-sact-for-lung-cancer-and-its-potential-for-interactions-with-other-medicines
#16
Ryan Panchal
BACKGROUND: Systemic anticancer therapy, comprising chemotherapy agents alongside targeted therapies and immunotherapy, is clinically indicated for late-stage lung cancer. It is delivered in regimens often containing multiple anticancer agents as well as supportive care medicines to reduce side effects, raising potential for polypharmacy and therefore the possibility of drug-drug interactions with medicines taken for comorbidities. A pharmacy-led process commonly performed to assist safe prescribing in secondary care is medicines reconciliation; its benefit in minimising interactions involving systemic anticancer therapy medicines has not been assessed previously...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28900477/breast-density-and-impacts-on-health
#17
EDITORIAL
Cheryl Cruwys, JoAnn Pushkin
The World Health Organization states 'Early detection in order to improve breast cancer outcome and survival remains the cornerstone of breast cancer control' [WHO (World Health Organization) (2017) Breast cancer: prevention and control Available from: http://www.who.int/cancer/detection/breastcancer/en/]. Breast Density Matters UK is a non-profit breast cancer organization. The organization's mission is to educate about breast density and its screening and risk implications with the goal of achieving the earliest stage diagnosis possible for women with dense breasts...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28900476/breast-cancer-in-angola-molecular-subtypes-a-first-glance
#18
Fernando Miguel, Lygia Vieira Lopes, Eduardo Ferreira, Emília Ribas, Alexis Fuentes Pelaez, Conceição Leal, Teresina Amaro, Paula Lopes, Cristina Mendes Santos, Carlos Lopes, Lúcio Lara Santos
PURPOSE: The aim of this study was to investigate the breast cancer (BC) molecular subtypes according to its surrogate immunohistochemistry (IHC) markers. We conducted a preliminary study, to correlate the clinical pathological profiles and molecular subtypes of breast cancer in Luanda, Angola. METHODS: From January 2011 to 30 December 2014, 140 consecutive cases of microscopically confirmed invasive breast carcinoma were classified regarding histology and IHC (ER, PR, HER2, and Ki-67)...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28900475/serum-biomarkers-to-predict-risk-of-testicular-and-penile-cancer-in-amoris
#19
Arunangshu Ghoshal, Hans Garmo, Rhonda Arthur, Niklas Hammar, Ingmar Jungner, Håkan Malmström, Mats Lambe, Göran Walldius, Mieke Van Hemelrijck
PURPOSE: To evaluate the association between commonly measured serum biomarkers of inflammation and penile and testicular cancer risk in the Swedish Apolipoprotein-related MORtality RISk (AMORIS) study. MATERIALS AND METHODS: A total of 205,717 subjects had baseline measurements of C-reactive protein, albumin, and haptoglobin. The association between quartiles and dichotomised values of inflammatory markers and penile and testicular cancer risk were analysed by using multivariate Cox proportional hazard models...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28900474/malignant-extra-adrenal-pelvic-paraganglioma-in-a-paediatric-patient
#20
Gabriel Cao, Julian Mendez, Daniel Navacchia
The extra-adrenal paraganglioma is a neoplasm originating in regional structures, uncommon in paediatrics. We report on a case of a 13-year-old patient who began with severe arterial hypertension, tachycardia, dilated cardiomyopathy and elevated levels of catecholamines in the blood and urine. The presence of a retrovesical pelvic mass in contact with the right vaginal dome was determined by imaging studies. A diagnosis of malignant extra-adrenal pelvic paraganglioma with lymph node metastases was reached through biopsy and the surgical resection of subsequent local recurrences...
2017: Ecancermedicalscience
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