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Andriy Anishkin, Sergei Sukharev
No abstract text is available yet for this article.
February 6, 2017: Channels
Antonella Gradogna, Héctor Gaitán-Peñas, Anna Boccaccio, Raúl Estévez, Michael Pusch
LRRC8 proteins have been shown to underlie the ubiquitous volume regulated anion channel (VRAC). VRAC channels are composed of the LRRC8A subunit and at least one among the LRRC8B-E subunits. In addition to their role in volume regulation, LRRC8 proteins have been implicated in the uptake of chemotherapeutic agents. We had found that LRRC8 channels can be conveniently expressed in Xenopus oocytes, a system without endogenous VRAC activity. The fusion with fluorescent proteins yielded constitutive activity for A/C, A/D and A/E heteromers...
January 25, 2017: Channels
Irwin B Levitan
No abstract text is available yet for this article.
January 24, 2017: Channels
Dan Feng, Haiyan Nan, Wen Wang, Linfeng Yan, Pang Du, Lin Zuo, Kun Zhang, Minggao Zhao, Guangbin Cui
This study aimed to investigate the expression and function of BKCa channels in the Sphincter of Oddi (SO) in a rabbit model of hypercholesterolemia (HC). New Zealand white rabbits were randomly divided into 2 groups: the control group was fed standard chow (n = 18) whereas the high-cholesterol group was fed cholesterol-enriched chow containing 1.5% cholesterol (n = 18). The serum cholesterol level was significantly greater in the HC groups than in the control group, but there was no significant difference in body weight between the control and HC groups...
January 19, 2017: Channels
Constanza Alcaino, Kaitlyn Knutson, Philip A Gottlieb, Gianrico Farrugia, Arthur Beyder
Enterochromaffin (EC) cells are the primary mechanosensors of the gastrointestinal (GI) epithelium. In response to mechanical stimuli EC cells release serotonin (5-hydroxytryptamine; 5-HT). The molecular details of EC cell mechanosensitivity are poorly understood. Recently, our group found that human and mouse EC cells express the mechanosensitive ion channel Piezo2. The mechanosensitive currents in a human EC cell model QGP-1 were blocked by the mechanosensitive channel blocker D-GsMTx4. In the present study we aimed to characterize the effects of the mechanosensitive ion channel inhibitor spider peptide D-GsMTx4 on the mechanically stimulated currents from both QGP-1 and human Piezo2 transfected HEK-293 cells...
January 13, 2017: Channels
Naaz Andharia, Ancy Joseph, Mikio Hayashi, Masayoshi Okada, Hiroko Matsuda
The TREK-1 channel, the TWIK-1-related potassium (K(+)) channel, is a member of a family of two-pore-domain K(+) (K2P) channels, through which background or leak K(+) currents occur. An interesting feature of the TREK-1 channel is the run-up of current: i.e. the current through TREK-1 channels spontaneously increases within several minutes of the formation of the whole-cell configuration. To investigate whether intracellular transport is involved in the run-up, we established 293T cell lines stably expressing the TREK-1c channel (K2P2...
January 13, 2017: Channels
Lars Jørn Jensen, Morten Schak Nielsen, Max Salomonsson, Charlotte Mehlin Sørensen
L-type voltage gated Ca(2+) channels are considered to be the primary source of calcium influx during the myogenic response. However, many vascular beds also express T-type voltage gated Ca(2+) channels. Recent studies suggest that these channels may also play a role in autoregulation. At low pressures (40-80 mmHg) T-type channels affect myogenic responses in cerebral and mesenteric vascular beds. T-type channels also seem to be involved in skeletal muscle autoregulation. This review discusses the expression and role of T-type voltage gated Ca(2+) channels in the autoregulation of several different vascular beds...
January 5, 2017: Channels
Teresa Giraldez
No abstract text is available yet for this article.
December 14, 2016: Channels
Larry Fliegel
No abstract text is available yet for this article.
December 9, 2016: Channels
Mircea C Iftinca, Christophe Altier
No abstract text is available yet for this article.
January 2, 2017: Channels
Berit Ebert, Carsten Rautengarten, Joshua L Heazlewood
No abstract text is available yet for this article.
January 2, 2017: Channels
Shuxi Ren, Chunli Pang, Junwei Li, Yayue Huang, Suhua Zhang, Yong Zhan, Hailong An
Kir2.1 plays key roles in setting rest membrane potential and modulation of cell excitability. Mutations of Kir2.1, such as D172N or E299V, inducing gain-of-function, can cause type3 short QT syndrome (SQT3) due to the enlarged outward currents. So far, there is no clinical drug target to block the currents of Kir2.1. Here, we identified a novel blocker of Kir2.1, styrax, which is a kind of natural compound selected from traditional Chinese medicine. Our data show that styrax can abolish the inward and outward currents of Kir2...
January 2, 2017: Channels
Aravind S Kshatri, Qin Li, Jiusheng Yan, Roddy J Large, Gerard P Sergeant, Noel G McHale, Keith D Thornbury, Mark A Hollywood
Large conductance, voltage and Ca(2+) activated K(+) channels (BK channels) are abundantly expressed throughout the body and are important regulators of smooth muscle tone and neuronal excitability. Their dysfunction is implicated in various diseases including overactive bladder, hypertension and erectile dysfunction. Therefore, BK channel openers bear significant therapeutic potential to treat the above diseases. GoSlo-SR compounds were designed to be potent and efficacious BK channel openers. Although their structural activity relationships, activation in both BKα and BKαβ channels and the hypothetical mode of action of these compounds has been studied in detail in recent years, their effectiveness to open the BKαγ channels still remains unexplored...
January 2, 2017: Channels
Sandra Feijóo-Bandín, María García-Vence, Vanessa García-Rúa, Esther Roselló-Lletí, Manuel Portolés, Miguel Rivera, José Ramón González-Juanatey, Francisca Lago
Two-pore channels (TPC1-3) comprise a subfamily of the eukaryotic voltage-gated ion channels (VGICs) superfamily that are mainly expressed in acidic stores in plants and animals. TPCS are widespread across the animal kingdom, with primates, mice and rats lacking TPC3, and mainly act as Ca(+) and Na(+) channels, although it was also suggested that they could be permeable to other ions. Nowadays, TPCs have been related to the development of different diseases, including Parkinson´s disease, obesity or myocardial ischemia...
January 2, 2017: Channels
Helena M Viola, Livia C Hool
No abstract text is available yet for this article.
January 2, 2017: Channels
Xinglong Yang, Hua Jia, Ran An, Jing Xi, Yanming Xu
Myotonia congenita (MC), paramyotonia congenita (PC) and sodium channel myotonias(SCM) were belonged to Non-dystrophic myotonias, in which muscle relaxation is delayed after voluntary or evoked contraction. These diseases can not be simply distinguished only based on symptoms and signs but also on genetics: more than 100 mutations in the CLCN1 gene have been associated with MC, while at least 20 mutations in the SCN4A gene have been associated with PC and SCM. Most of these genetics studies have been conducted outside China, only several MC, PC, and SCM families accepted gene scan were reported in China...
January 2, 2017: Channels
Letizia Albarran, Sergio Regodón, Gines M Salido, Jose J Lopez, Juan A Rosado
The store-operated Ca(2+) entry-associated regulatory factor (SARAF), a protein expressed both in the endoplasmic reticulum and the plasma membrane, has been presented as a STIM1-interacting protein with the ability to modulate intracellular Ca(2+) homeostasis. SARAF negatively modulates store-operated Ca(2+) entry (SOCE) by preventing STIM1 spontaneous activation and regulating STIM1-Orai1 complex formation. In addition, SARAF is a negative regulator of Ca(2+) entry through the arachidonate-regulated Ca(2+) (ARC) channels...
January 2, 2017: Channels
Hongwei Cheng, Andrew F James, Mark R Boyett, Jules C Hancox
No abstract text is available yet for this article.
January 2, 2017: Channels
Luca Avenali, Oli Abate Fulas, Julia Sondermann, Pratibha Narayanan, David Gomez-Varela, Manuela Schmidt
The ability of sensory neurons to detect potentially harmful stimuli relies on specialized molecular signal detectors such as transient receptor potential (TRP) A1 ion channels. TRPA1 is critically implicated in vertebrate nociception and different pain states. Furthermore, TRPA1 channels are subject to extensive modulation and regulation - processes which consequently affect nociceptive signaling. Here we show that the neuropeptide Nocistatin sensitizes TRPA1-dependent calcium influx upon application of the TRPA1 agonist mustard oil (MO) in cultured sensory neurons of dorsal root ganglia (DRG)...
January 2, 2017: Channels
Nan Liu, Yuxia Liu, Yaxiong Yang, Xiaodong Liu
Extracellular S3-S4 linkers of domain IV (IVS3-S4) of L-type Ca(2+) channels (CaV1) are subject to alternative splicing, resulting into distinct gating profiles serving for diverse physiological roles. However, it has remained elusive what would be the determining factor of IVS3-S4 effects on CaV1 channels. In this study, we systematically compared IVS3-S4 variants from CaV1.1-1.4, and discover that the flexibility of the linker plays a prominent role in gating characteristics. Chimeric analysis and mutagenesis demonstrated that changes in half activation voltage (V1/2) or activation time constant (τ) are positively correlated with the numbers of flexible glycine residues within the linker...
January 2, 2017: Channels
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