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https://www.readbyqxmd.com/read/28644055/regulation-of-transient-receptor-potential-melastatin-4-channel-by-sarcoplasmic-reticulum-inositol-triphosphate-receptors-role-in-human-detrusor-smooth-muscle-function
#1
Aaron Provence, Eric S Rovner, Georgi V Petkov
We recently reported key physiological roles for Ca(2+)-activated transient receptor potential melastatin 4 (TRPM4) channels in detrusor smooth muscle (DSM). However, the Ca(2+)-signaling mechanisms governing TRPM4 channel activity in human DSM cells are unexplored. As the TRPM4 channels are activated by Ca(2+), inositol 1,4,5-trisphosphate receptor (IP3R)-mediated Ca(2+) release from the sarcoplasmic reticulum represents a potential Ca(2+) source for TRPM4 channel activation. We used clinically-characterized human DSM tissues to investigate the molecular and functional interactions of the IP3Rs and TRPM4 channels...
June 23, 2017: Channels
https://www.readbyqxmd.com/read/28636485/mineralocorticoids-modulate-the-expression-of-the-beta-3-subunit-of-the-na-k-atpase-in-the-renal-collecting-duct
#2
Macarena Rojas, Pablo Díaz, Pablo León, Alexis A González, Magdalena González, Víctor Barrientos, Nikolay B Pestov, Rodrigo Alzamora, Luis Michea
Renal sodium reabsorption depends on the activity of the Na(+),K(+)-ATPase α/β heterodimer. Four α (α1-4) and three β (β1-3) subunit isoforms have been described. It is accepted that renal tubule cells express α1/β1 dimers. Aldosterone stimulates Na(+),K(+)-ATPase activity and may modulate α1/β1 expression. However, some studies suggest the presence of β3 in the kidney. We hypothesized that the β3 isoform of the Na(+),K(+)-ATPase is expressed in tubular cells of the distal nephron, and modulated by mineralocorticoids...
June 21, 2017: Channels
https://www.readbyqxmd.com/read/28636428/fk506-binding-proteins-12-and-12-6-fkbps-as-regulators-of-cardiac-ryanodine-receptors-insights-from-new-functional-and-structural-knowledge
#3
Luis Alberto Gonano, Peter P Jones
Ryanodine Receptors (RyRs) are intracellular Ca(2+) channels that mediate Ca(2+) flux from the sarco(endo)plasmic reticulum in many cell types. The interaction of RyRs with FK506-binding proteins (FKBPs) has been proposed as an important regulatory mechanism, where the loss of this interaction leads to channel dysfunction. In the heart, phosphorylation of RyR has been suggested to disrupt the RyR-FKBP interaction promoting altered Ca(2+) signalling, heart failure and arrhythmias. However, the functional result of FKBP interaction with RyR and how this interaction is regulated remains highly controversial...
June 21, 2017: Channels
https://www.readbyqxmd.com/read/28633002/the-trpm2-channel-a-thermo-sensitive-metabolic-sensor
#4
Makiko Kashio, Makoto Tominaga
Living organisms continually experience changes in ambient temperature. In order to detect such temperature changes for adaptive behavioral responses, we evolved the ability to sense temperature. Thermosensitive transient receptor potential (TRP) channels, so-called thermo-TRPs, are involved in many physiological functions in diverse organisms and constitute important temperature sensors. One of the important roles of thermo-TRPs is detecting ambient temperature in sensory neurons. Importantly, the functional expression of thermo-TRPs is observed not only in sensory neurons but also in tissues and cells that are not exposed to drastic temperature changes, indicating that thermo-TRPs are involved in many physiological functions within the body's normal temperature range...
June 20, 2017: Channels
https://www.readbyqxmd.com/read/28617626/understanding-the-rules-governing-ncx1-palmitoylation
#5
Fiona Plain, Dionne Turnbull, Niall J Fraser, William Fuller
No abstract text is available yet for this article.
June 15, 2017: Channels
https://www.readbyqxmd.com/read/28598266/reversible-lysine-acetylation-another-layer-of-post-translational-regulation-of-the-cardiac-sodium-channel
#6
Jin-Young Yoon, Ajit Vikram, Barry London, Kaikobad Irani
No abstract text is available yet for this article.
June 9, 2017: Channels
https://www.readbyqxmd.com/read/28569643/the-hook-region-of-%C3%AE-subunits-controls-gating-of-voltage-gated-ca-2-channels-by-electrostatically-interacting-with-plasma-membrane
#7
Cheon-Gyu Park, Byung-Chang Suh
Recently, we showed that the HOOK region of the β2 subunit electrostatically interacts with the plasma membrane and regulates the current inactivation and phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of voltage-gated Ca(2+) (CaV) 2.2 channels. Here, we report that voltage-dependent gating and current density of the CaV2.2 channels are also regulated by the HOOK region of the β2 subunit. The HOOK region can be divided into 3 domains: S (polyserine), A (polyacidic), and B (polybasic). We found that the A domain shifted the voltage-dependent inactivation and activation of CaV2...
June 1, 2017: Channels
https://www.readbyqxmd.com/read/28558254/sensing-the-cold-trp-channels-in-thermal-nociception
#8
Nathaniel J Himmel, Daniel N Cox
No abstract text is available yet for this article.
May 30, 2017: Channels
https://www.readbyqxmd.com/read/28514187/diphenhydramine-inhibits-voltage-gated-proton-channels-hv1-and-induces-acidification-in-leukemic-jurkat-t-cells-new-insights-into-the-pro-apoptotic-effects-of-antihistaminic-drugs
#9
Agustín Asuaje, Pedro Martín, Nicolás Enrique, Leandro Agustín Díaz Zegarra, Paola Smaldini, Guillermo Docena, Verónica Milesi
An established characteristic of neoplastic cells is their metabolic reprogramming, known as the Warburg effect, with greater reliance on energetically less efficient pathways (such as glycolysis and pentose phosphate shunt) compared with oxidative phosphorylation. This results in an overproduction of acidic species that must be extruded to maintain intracellular homeostasis. We recently described that blocking the proton currents in leukemic cells mediated by Hv1 ion channels triggers a marked intracellular acidification and apoptosis induction...
May 17, 2017: Channels
https://www.readbyqxmd.com/read/28498780/ap-and-ca-2-alternans-an-inseparable-couple
#10
Giedrius Kanaporis, Lothar A Blatter
No abstract text is available yet for this article.
May 12, 2017: Channels
https://www.readbyqxmd.com/read/28494190/formate-nitrite-transporters-monoacids-ride-the-dielectric-slide
#11
Marie Wiechert, Eric Beitz
No abstract text is available yet for this article.
May 11, 2017: Channels
https://www.readbyqxmd.com/read/28481659/ion-channel-mechanisms-underlying-frequency-firing-patterns-of-the-avian-nucleus-magnocellularis-a-computational-model
#12
Ting Lu, Kirstie Wade, Hui Hong, Jason Tait Sanchez
We have previously shown that late-developing avian nucleus magnocellularis (NM) neurons (embryonic [E] days 19-21) fire action potentials (APs) that resembles a band-pass filter in response to sinusoidal current injections of varying frequencies. NM neurons located in the mid- to high-frequency regions of the nucleus fire preferentially at 75 Hz, but only fire a single onset AP to frequency inputs greater than 200 Hz. Surprisingly, NM neurons do not fire APs to sinusoidal inputs less than 20 Hz regardless of the strength of the current injection...
May 8, 2017: Channels
https://www.readbyqxmd.com/read/28467171/down-regulation-of-t-type-cav3-2-channels-by-hyperpolarization-activated-cyclic-nucleotide-gated-channel-1-hcn1-evidence-of-a-signaling-complex
#13
Jing Fan, Maria A Gandini, Fang-Xiong Zhang, Lina Chen, Ivana A Souza, Gerald W Zamponi
Formation of complexes between ion channels is important for signal processing in the brain. Here we investigate the biochemical and biophysical interactions between HCN1 channels and Cav3.2 T-type channels. We found that HCN1 co-immunoprecipitated with Cav3.2 from lysates of either mouse brain or tsA-201 cells, with the HCN1 N-terminus associating with the Cav3.2 N-terminus. Cav3.2 channel activity appeared to be functionally regulated by HCN1. The expression of HCN1 induced a decrease in Cav3.2 Ba(2+) influx (IBa(2+)) along with altered channel kinetics and a depolarizing shift in activation gating...
May 3, 2017: Channels
https://www.readbyqxmd.com/read/28459611/%C3%AE-arrestin-1-bridging-gpcrs-to-active-trp-channels
#14
Zuying Chai, Yang Chen, Changhe Wang
No abstract text is available yet for this article.
May 1, 2017: Channels
https://www.readbyqxmd.com/read/28418760/aromatic-dipeptide-trp-ala-can-be-transported-by-arabidopsis-peptide-transporters-atptr1-and-atptr5
#15
Diyang Qiu, Rui Hu, Ying Li, Mingyong Zhang
Dipeptides with an aromatic residue at the N-terminal position induced lower inward currents or blocked leak currents in Xenopus oocytes expressing the proton-coupled peptide transporter AtPTR1 or AtPTR5 of Arabidopsis thaliana compared with dipeptides with an aromatic residue at the C-terminal position. Here, AtPTR1 and AtPTR5 were expressed in a yeast mutant of peptide transporter (ptr2) with tryptophan auxotrophy. Growth assays showed that Trp-Ala could be transported by both AtPTR1 and AtPTR5 as efficiently as Ala-Trp...
April 18, 2017: Channels
https://www.readbyqxmd.com/read/28399685/pico145-powerful-new-tool-for-trpc1-4-5-channels
#16
Hussein N Rubaiy, Melanie J Ludlow, Robin S Bon, David J Beech
No abstract text is available yet for this article.
April 11, 2017: Channels
https://www.readbyqxmd.com/read/28166450/channel-disassembled-pick-tweak-and-soak-parts-to-soften
#17
Andriy Anishkin, Sergei Sukharev
No abstract text is available yet for this article.
May 4, 2017: Channels
https://www.readbyqxmd.com/read/28121479/cisplatin-activates-volume-sensitive-lrrc8-channel-mediated-currents-in-xenopus-oocytes
#18
Antonella Gradogna, Héctor Gaitán-Peñas, Anna Boccaccio, Raúl Estévez, Michael Pusch
LRRC8 proteins have been shown to underlie the ubiquitous volume regulated anion channel (VRAC). VRAC channels are composed of the LRRC8A subunit and at least one among the LRRC8B-E subunits. In addition to their role in volume regulation, LRRC8 proteins have been implicated in the uptake of chemotherapeutic agents. We had found that LRRC8 channels can be conveniently expressed in Xenopus oocytes, a system without endogenous VRAC activity. The fusion with fluorescent proteins yielded constitutive activity for A/C, A/D and A/E heteromers...
May 4, 2017: Channels
https://www.readbyqxmd.com/read/28102743/expression-and-alteration-of-bkca-channels-in-the-sphincter-of-oddi-s-from-rabbits-with-hypercholesterolemia
#19
Dan Feng, Haiyan Nan, Wen Wang, Linfeng Yan, Pang Du, Lin Zuo, Kun Zhang, Minggao Zhao, Guangbin Cui
This study aimed to investigate the expression and function of BKCa channels in the Sphincter of Oddi (SO) in a rabbit model of hypercholesterolemia (HC). New Zealand white rabbits were randomly divided into 2 groups: the control group was fed standard chow (n = 18) whereas the high-cholesterol group was fed cholesterol-enriched chow containing 1.5% cholesterol (n = 18). The serum cholesterol level was significantly greater in the HC groups than in the control group, but there was no significant difference in body weight between the control and HC groups...
May 4, 2017: Channels
https://www.readbyqxmd.com/read/28085630/mechanosensitive-ion-channel-piezo2-is-inhibited-by-d-gsmtx4
#20
Constanza Alcaino, Kaitlyn Knutson, Philip A Gottlieb, Gianrico Farrugia, Arthur Beyder
Enterochromaffin (EC) cells are the primary mechanosensors of the gastrointestinal (GI) epithelium. In response to mechanical stimuliEC cells release serotonin (5-hydroxytryptamine; 5-HT). The molecular details ofEC cell mechanosensitivity are poorly understood. Recently, our group found that human and mouseEC cells express the mechanosensitive ion channel Piezo2. The mechanosensitive currents in a humanEC cell model QGP-1 were blocked by the mechanosensitive channel blocker D-GsMTx4. In the present study we aimed to characterize the effects of the mechanosensitive ion channel inhibitor spider peptide D-GsMTx4 on the mechanically stimulated currents from both QGP-1 and human Piezo2 transfected HEK-293 cells...
May 4, 2017: Channels
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