journal
MENU ▼
Read by QxMD icon Read
search

Channels

journal
https://www.readbyqxmd.com/read/28922053/distribution-and-function-of-voltage-gated-sodium-channels-in-the-nervous-system
#1
Jun Wang, Shao-Wu Ou, Yun-Jie Wang
Voltage-gated sodium channels (VGSCs) are the basic ion channels for neuronal excitability, which are crucial for the resting potential and the generation and propagation of action potentials in neurons. To date, at least nine distinct sodium channel isoforms have been detected in the nervous system. Recent studies have identified that voltage-gated sodium channels not only play an essential role in the normal electrophysiological activities of neurons but also have a close relationship with neurological diseases...
September 18, 2017: Channels
https://www.readbyqxmd.com/read/28901828/protein-kinase-c-enhances-plasma-membrane-expression-of-cardiac-l-type-calcium-channel-cav1-2
#2
Tal Keren Raifman, Prabodh Kumar, Hannelore Haase, Enno Klussmann, Nathan Dascal, Sharon Weiss
L-type-voltage-dependent Ca(2+) channels (L-VDCCs; CaV1.2, α1C), crucial in cardiovascular physiology and pathology, are modulated via activation of G-protein-coupled receptors and subsequently protein kinase C (PKC). Despite extensive study, key aspects of the mechanisms leading to PKC-induced Ca(2+) current increase are unresolved. A notable residue, Ser1928, located in the distal C-terminus (dCT) of α1C was shown to be phosphorylated by PKC. CaV1.2 undergoes posttranslational modifications yielding full-length and proteolytically cleaved CT-truncated forms...
September 13, 2017: Channels
https://www.readbyqxmd.com/read/28876978/are-there-superagonists-for-calcium-activated-potassium-channels
#3
Brandon M Brown, Heesung Shim, Heike Wulff
No abstract text is available yet for this article.
September 6, 2017: Channels
https://www.readbyqxmd.com/read/28876976/trpm4-activation-by-chemically-and-oxygen-deprivation-induced-ischemia-and-reperfusion-triggers-neuronal-death
#4
Elías Leiva-Salcedo, Denise Riquelme, Oscar Cerda, Andrés Stutzin
Cerebral ischemia-reperfusion injury triggers a deleterious process ending in neuronal death. This process has two components, a glutamate-dependent and a glutamate-independent mechanism. In the glutamate-independent mechanism, neurons undergo a slow depolarization eventually leading to neuronal death. However, little is known about the molecules that take part in this process. Here we show by using mice cortical neurons in culture and ischemia-reperfusion protocols that TRPM4 is fundamental for the glutamate-independent neuronal damage...
September 6, 2017: Channels
https://www.readbyqxmd.com/read/28876960/trpm2-shredding-the-mitochondrial-network
#5
Fangfang Li, Nada Abuarab, Asipu Sivaprasadarao
No abstract text is available yet for this article.
September 6, 2017: Channels
https://www.readbyqxmd.com/read/28873008/induction-of-adipose-and-hepatic-swell1-expression-is-required-for-maintaining-systemic-insulin-sensitivity-in-obesity
#6
Litao Xie, Yanhui Zhang, Susheel Gunasekar, Anil Mishra, Lei Cao, Rajan Sah
Obesity is associated with a loss of insulin-sensitivity and systemic dysglycemia, resulting in Type 2 diabetes, however the molecular mechanisms underlying this association are unclear. Through adipocyte patch-clamp studies, we recently showed that SWELL1 is required for the Volume-Regulated Anion Current (VRAC) in adipocytes and that SWELL1-mediated VRAC is activated by both mechanical and pathophysiological adipocyte expansion. We also demonstrated that adipocyte SWELL1 is required for maintaining insulin signaling and glucose homeostasis, particularly in the setting of obesity...
September 5, 2017: Channels
https://www.readbyqxmd.com/read/28837400/80pkc-sumoylation-inhibits-the-binding-of-14-3-3%C3%AF-to-gluk2
#7
Xiaoling Li, Yan Wang, Aoxue Zhu, Jie Zhou, Yong Li
Phosphorylation and SUMOylation of the kainate receptor (KAR) subunit GluK2 have been shown to regulate KAR surface expression, trafficking and synaptic plasticity. In addition, our previous study has shown that a phosphorylation-dependent interaction of 14-3-3τ and GluK2a-containing receptors contributes to the slow decay kinetics of native KAR-EPSCs. However, it is unknown whether SUMOylation participates in the regulation of the interaction between 14-3-3τ and GluK2a-containing receptors. Here we report that SUMOylation of PKC, but not GluK2, represses the binding of 14-3-3τ to GluK2a via decreasing the phosphorylation level of GluK2a...
August 24, 2017: Channels
https://www.readbyqxmd.com/read/28837387/crmp2-is-necessary-for-neurofibromatosis-type-1-related-pain
#8
Aubin Moutal, Song Cai, Shizhen Luo, Raphaëlle Voisin, Rajesh Khanna
Neurofibromatosis type 1 (NF1) is one of the most common genetic diseases, affecting roughly 1 in 3000 individuals. As a multisystem disorder, it affects cognitive development, as well as bone, nerve and muscle constitution. Peripheral neuropathy in NF1 constitutes a potentially severe clinical complication and is associated with increased morbidity and mortality. The discovery of effective therapies for Neurofibromatosis type 1 (NF1) pain depends on mechanistic understanding that has been limited, in part, by the relative lack of availability of animal models relevant to NF1 pain...
August 24, 2017: Channels
https://www.readbyqxmd.com/read/28837385/mechanisms-and-models-of-cardiac-sodium-channel-inactivation
#9
Kathryn E Mangold, Brittany D Brumback, Paweorn Angsutararux, Taylor L Voelker, Wandi Zhu, Po Wei Kang, Jonathan Moreno, Jonathan R Silva
Shortly after cardiac Na(+) channels activate and initiate the action potential, inactivation ensues within milliseconds, attenuating the peak Na(+) current, INa, and allowing the cell membrane to repolarize. A very limited number of Na(+) channels that do not inactivate carry a persistent INa, or late INa. While late INa is only a small fraction of peak magnitude, it significantly prolongs ventricular action potential duration, which predisposes patients to arrhythmia. Here, we review our current understanding of inactivation mechanisms, their regulation and how they have been modeled computationally...
August 24, 2017: Channels
https://www.readbyqxmd.com/read/28837380/cav2-channel-subtype-expression-in-rat-sympathetic-neurons-is-selectively-regulated-by-%C3%AE-2%C3%AE-subunits
#10
Mallory B Scott, Paul J Kammermeier
Type two voltage gated calcium (CaV2) channels are the primary mediators of neurotransmission at neuronal presynapses, but their function at neural soma is also important in regulating excitability (1) . Mechanisms that regulate CaV2 channel expression at synapses have been studied extensively, which motivated us to perform similar studies in the soma. Rat sympathetic neurons from the superior cervical ganglion (SCG) natively express CaV2.2 and CaV2.3 (2) . We noted previously that heterologous expression of CaV2...
August 24, 2017: Channels
https://www.readbyqxmd.com/read/28806132/plight-of-the-pore-polar-bar-rier
#11
Jerod S Denton, Sujay V Kharade
No abstract text is available yet for this article.
August 14, 2017: Channels
https://www.readbyqxmd.com/read/28796561/kir-channels-mediate-vasodilation-but-not-sympatholysis
#12
Christopher M Hearon, Frank A Dinenno
No abstract text is available yet for this article.
August 10, 2017: Channels
https://www.readbyqxmd.com/read/28792844/trpa1-ion-channel-stimulation-enhances-cardiomyocyte-contractile-function-via-a-camkii-dependent-pathway
#13
Spencer R Andrei, Monica Ghosh, Pritam Sinharoy, Souvik Dey, Ian N Bratz, Derek S Damron
RATIONALE: Transient receptor potential channels of the ankyrin subtype-1 (TRPA1) are non-selective cation channels that show high permeability to calcium. Previous studies from our laboratory have demonstrated that TRPA1 ion channels are expressed in adult mouse ventricular cardiomyocytes (CMs) and are localized at the z-disk, costamere and intercalated disk. The functional significance of TRPA1 ion channels in the modulation of CM contractile function have not been explored. OBJECTIVE: To identify the extent to which TRPA1 ion channels are involved in modulating CM contractile function and elucidate the cellular mechanism of action...
August 9, 2017: Channels
https://www.readbyqxmd.com/read/28762890/the-latency-of-the-light-response-is-modulated-by-the-phosphorylation-state-of-drosophila-trp-at-a-specific-site
#14
Ben Katz, Olaf Voolstra, Hanan Tzadok, Bushra Yasin, Elisheva Rhodes-Modrov, Jonas-Peter Bartels, Lisa Strauch, Armin Huber, Baruch Minke
Drosophila photoreceptors respond to oscillating light of high frequency (∼100 Hz), while increasing the oscillating light intensity raises the maximally detected frequency. Recently, we reported that dephosphorylation of the light-activated TRP ion channel at S936 is a fast, graded, light-, and Ca(2+)-dependent process. We further found that this process affects the detection limit of high frequency oscillating light. Accordingly, transgenic Drosophila, which do not undergo phosphorylation at the S936-TRP site (trp(S936A)), revealed a short time-interval before following the high stimulus frequency (oscillation-lock response) in both dark- and light-adapted flies...
August 1, 2017: Channels
https://www.readbyqxmd.com/read/28745932/genetic-deletion-of-microglial-panx1-attenuates-morphine-withdrawal-but-not-analgesic-tolerance-or-hyperalgesia-in-mice
#15
Nicole E Burma, Heather Leduc-Pessah, Tuan Trang
Opioids are among the most powerful analgesics for managing pain, yet their repeated use can lead to the development of severe adverse effects. In a recent study, we identified the microglial pannexin-1 channel (Panx1) as a critical substrate for opioid withdrawal. Here, we investigated whether microglial Panx1 contributes to opioid-induced hyperalgesia (OIH) and opioid analgesic tolerance using mice with a tamoxifen-inducible deletion of microglial Panx1. We determined that escalating doses of morphine resulted in thermal pain hypersensitivity in both Panx1-expressing and microglial Panx1-deficient mice...
July 26, 2017: Channels
https://www.readbyqxmd.com/read/28742985/gabab-receptors-suppress-burst-firing-in-reticular-thalamic-neurons
#16
Stuart M Cain, Esperanza Garcia, Zeina Waheed, Karen L Jones, Trevor J Bushell, Terrance P Snutch
Burst-firing in thalamic neurons is known to play a key role in mediating thalamocortical (TC) oscillations that are associated with non-REM sleep and some types of epileptic seizure. Within the TC system the primary output of GABAergic neurons in the reticular thalamic nucleus (RTN) is thought to induce the de-inactivation of T-type calcium channels in thalamic relay (TR) neurons, promoting burst-firing drive to the cortex and the propagation of TC network activity. However, RTN neurons also project back onto other neurons within the RTN...
July 25, 2017: Channels
https://www.readbyqxmd.com/read/28723241/the-effects-of-stretch-activation-on-ionic-selectivity-of-the-trek-2-k2p-k-channel
#17
Ehsan Nematian-Ardestani, Viwan Jarerattanachat, Prafulla Aryal, Mark S P Sansom, Stephen J Tucker
The TREK-2 (KCNK10) K2P potassium channel can be regulated by variety of polymodal stimuli including pressure. In a recent study, we demonstrated that this mechanosensitive K(+) channel responds to changes in membrane tension by undergoing a major structural change from its 'down' state to the more expanded 'up' state conformation. These changes are mostly restricted to the lower part of the protein within the bilayer, but are allosterically coupled to the primary gating mechanism located within the selectivity filter...
July 19, 2017: Channels
https://www.readbyqxmd.com/read/28723237/linking-chanelopathies-with-endoplasmic-reticulum-associated-degradation
#18
Brighid M O'Donnell, Timothy D Mackie, Jeffrey L Brodsky
No abstract text is available yet for this article.
July 19, 2017: Channels
https://www.readbyqxmd.com/read/28718687/do-sodium-channel-proteolytic-fragments-regulate-sodium-channel-expression
#19
Donatus O Onwuli, Laia Yañez-Bisbe, Mel Lina Pinsach-Abuin, Anna Tarradas, Ramon Brugada, John Greenman, Sara Pagans, Pedro Beltran-Alvarez
The cardiac voltage-gated sodium channel (gene: SCN5A, protein: NaV1.5) is responsible for the sodium current that initiates the cardiomyocyte action potential. Research into the mechanisms of SCN5A gene expression has gained momentum over the last few years. We have recently described the transcriptional regulation of SCN5A by GATA4 transcription factor. In this addendum to our study, we report our observations that 1) the linker between domains I and II (LDI-DII) of NaV1.5 contains a nuclear localization signal (residues 474-481) that is necessary to localize LDI-DII into the nucleus, and 2) nuclear LDI-DII activates the SCN5A promoter in gene reporter assays using cardiac-like H9c2 cells...
July 18, 2017: Channels
https://www.readbyqxmd.com/read/28699817/how-may-pi-3-5-p2-impact-on-vacuolar-acidification
#20
Joachim Scholz-Starke
No abstract text is available yet for this article.
July 12, 2017: Channels
journal
journal
41820
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"