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https://www.readbyqxmd.com/read/27835060/impaired-camp-cgmp-cross-talk-during-cardiac-sympathetic-dysautonomia
#1
Emma N Bardsley, Hege E Larsen, David J Paterson
No abstract text is available yet for this article.
November 11, 2016: Channels
https://www.readbyqxmd.com/read/27813693/loss-of-hcn-channel-mediated-ih-current-following-seizures-accounts-for-movement-dysfunction
#2
Jeffery A Boychuk, G Campbell Teskey
No abstract text is available yet for this article.
November 4, 2016: Channels
https://www.readbyqxmd.com/read/27764579/specific-and-essential-but-not-sufficient-roles-of-lrrc8a-in-the-activity-of-volume-sensitive-outwardly-rectifying-anion-channel-vsor
#3
Toshiaki Okada, Md Rafiqul Islam, Nargiza A Tsiferova, Yasunobu Okada, Ravshan Z Sabirov
The broadly expressed volume-sensitive outwardly rectifying anion channel (VSOR, also called VRAC) plays essential roles in cell survival and death. Recent findings have suggested that LRRC8A is a core component of VSOR in human cells. In the present study, VSOR currents were found to be largely reduced by siRNA against LRRC8A in mouse C127 cells as well. In contrast, LRRC8A knockdown never affected activities of four other types of anion channel activated by acid, Ca(2+), patch excision or cAMP. While cisplatin-resistant KCP-4 cells poorly expressed endogenous VSOR activity, molecular expression levels of LRRC8A, LRRC8D and LRRC8E were indistinguishable between VSOR-deficient KCP-4 cells and the parental VSOR-rich KB cells...
October 20, 2016: Channels
https://www.readbyqxmd.com/read/27754757/trpv3-mutants-causing-olmsted-syndrome-induce-impaired-cell-adhesion-and-nonfunctional-lysosomes
#4
Manoj Yadav, Chandan Goswami
TRPV3 is a non-selective cationic channel and is important for several physiological functions. It can be activated by physiological temperature and selective endogenous and exogenous compounds. TRPV3 is one of the key ion channel involved in Ca(2+)-signaling in keratinocyte and thus involved in skin-related functions. Recently, naturally occurring mutations in TRPV3, namely G573A, G573S, G573C and W692G have been detected which are linked with the development of pathophysiological conditions such as Olmsted Syndrome (OS) and other skin disorders...
October 18, 2016: Channels
https://www.readbyqxmd.com/read/27753526/nanomechanical-properties-of-mscl-alpha-helices-a-steered-molecular-dynamics-study
#5
N Bavi, O Bavi, M Vossoughi, R Naghdabadi, A P Hill, B Martinac, Y Jamali
Gating of mechanosentive (MS) channels is driven by a hierarchical cascade of movements and deformations of transmembrane helices in response to bilayer tension. Determining the intrinsic mechanical properties of the individual transmembrane helices is therefore central to understanding the intricacies of the gating mechanism of MS channels. We used a constant-force steered molecular dynamics (SMD) approach to perform unidirectional pulling tests on all the helices of MscL in M. tuberculosis and E. coli homologs...
October 18, 2016: Channels
https://www.readbyqxmd.com/read/27736292/orai1-regulates-calcium-entry-into-dendritic-spines
#6
Eduard Korkotian, Menahem Segal
No abstract text is available yet for this article.
October 13, 2016: Channels
https://www.readbyqxmd.com/read/27690717/the-glycosylation-of-the-extracellular-loop-of-%C3%AE-2-subunits-diversifies-functional-phenotypes-of-bk-channels
#7
Zhi-Gang Huang, Hao-Wen Liu, Zhen-Zhen Yan, Sheng Wang, Lu-Yang Wang, Jiu-Ping Ding
Large-conductance Ca(2+)- and voltage- activated potassium (MaxiK or BK) channels are composed of a pore-forming α subunit (Slo) and four types of auxiliary β subunits or just a pore-forming α subunit. Although multiple N-linked glycosylation sites in the extracellular loop of β subunits have been identified, very little is known about how glycosylation influences the structure and function of BK channels. Using a combination of site-directed mutagenesis, western blot and patch-clamp recordings, we demonstrated that three sites in the extracellular loop of β2 subunit are N-glycosylated (N-X-T/S at N88, N96 and N119)...
October 3, 2016: Channels
https://www.readbyqxmd.com/read/27689426/hysteresis-in-voltage-gated-channels
#8
Carlos A Villalba-Galea
Ion channels constitute a superfamily of membrane proteins found in all living creatures. Their activity allows fast translocation of ions across the plasma membrane down the ion's transmembrane electrochemical gradient, resulting in a difference in electrical potential across the plasma membrane, known as the membrane potential. A group within this superfamily, namely voltage-gated channels, displays activity that is sensitive to the membrane potential. The activity of voltage-gated channels is controlled by the membrane potential, while the membrane potential is changed by these channels' activity...
September 30, 2016: Channels
https://www.readbyqxmd.com/read/27682595/stacking-up-cav3-2-channels
#9
Mircea C Iftinca, Christophe Altier
No abstract text is available yet for this article.
September 28, 2016: Channels
https://www.readbyqxmd.com/read/27657932/a-new-direction-for-spreading-depolarization-investigation-in-the-fly-brain
#10
Kristin E Spong, Jens P Dreier, R Meldrum Robertson
No abstract text is available yet for this article.
September 22, 2016: Channels
https://www.readbyqxmd.com/read/27653665/t-type-calcium-channels-in-synaptic-plasticity
#11
Nathalie Leresche, Régis C Lambert
The role of T-type calcium currents is rarely considered in the extensive literature covering the mechanisms of long-term synaptic plasticity. This situation reflects the lack of suitable T-type channel antagonists that till recently has hampered investigations of the functional roles of these channels. However, with the development of new pharmacological and genetic tools, a clear involvement of T-type channels in synaptic plasticity is starting to emerge. Here, we review a number of studies showing that T-type channels participate to numerous homo- and hetero-synaptic plasticity mechanisms that involve different molecular partners and both pre- and post-synaptic modifications...
September 21, 2016: Channels
https://www.readbyqxmd.com/read/27367642/dynamical-characterization-of-inactivation-path-in-voltage-gated-na-ion-channel-by-non-equilibrium-response-spectroscopy
#12
Krishnendu Pal, Gautam Gangopadhyay
Inactivation path of voltage gated sodium channel has been studied here under various voltage protocols as it is the main governing factor for the periodic occurrence and shape of the action potential. These voltage protocols actually serve as non-equilibrium response spectroscopic tools to study the ion channel in non-equilibrium environment. In contrast to a lot of effort in finding the crystal structure based molecular mechanism of closed-state(CSI) and open-state inactivation(OSI); here our approach is to understand the dynamical characterization of inactivation...
November 2016: Channels
https://www.readbyqxmd.com/read/27367557/5-n-n-hexamethylene-amiloride-is-a-gaba-a-%C3%AF-1-receptor-positive-allosteric-modulator
#13
Heather D Snell, Eric B Gonzales
Guanidine compounds act as ion channel modulators. In the case of Cys-loop receptors, the guanidine compound amiloride antagonized the heteromeric GABA-A, glycine, and nicotinic acetylcholine receptors. However, amiloride exhibits characteristics consistent with a positive allosteric modulator for the human GABA-A (hGABA-A) ρ1 receptor. Site-directed mutagenesis revealed that the positive allosteric modulation was influenced by the GABA-A ρ1 second transmembrane domain 15' position, a site implicated in ligand allosteric modulation of Cys-loop receptors...
November 2016: Channels
https://www.readbyqxmd.com/read/27362266/regulation-and-function-of-the-slc38a3-snat3-glutamine-transporter
#14
Isabel Rubio-Aliaga, Carsten A Wagner
No abstract text is available yet for this article.
November 2016: Channels
https://www.readbyqxmd.com/read/27356267/ca-2-activated-chloride-channel-activity-during-ca-2-alternans-in-ventricular-myocytes
#15
Giedrius Kanaporis, Lothar A Blatter
Cardiac alternans, defined beat-to-beat alternations in contraction, action potential (AP) morphology or cytosolic Ca transient (CaT) amplitude, is a high risk indicator for cardiac arrhythmias. We investigated mechanisms of cardiac alternans in single rabbit ventricular myocytes. CaTs were monitored simultaneously with membrane currents or APs recorded with the patch clamp technique. A strong correlation between beat-to-beat alternations of AP morphology and CaT alternans was observed. During CaT alternans application of voltage clamp protocols in form of pre-recorded APs revealed a prominent Ca(2+)-dependent membrane current consisting of a large outward component coinciding with AP phases 1 and 2, followed by an inward current during AP repolarization...
November 2016: Channels
https://www.readbyqxmd.com/read/27351304/ifgf14-navs-a-monogamous-partnership
#16
Sulayman D Dib-Hajj
No abstract text is available yet for this article.
November 2016: Channels
https://www.readbyqxmd.com/read/27347774/two-aquaporins-multiple-ways-of-assembly
#17
Cintia Jozefkowicz, Florencia Scochera, Karina Alleva
No abstract text is available yet for this article.
November 2016: Channels
https://www.readbyqxmd.com/read/27341662/germs-against-pain-humanized-bacterial-sodium-channels
#18
Angelika Lampert
No abstract text is available yet for this article.
November 2016: Channels
https://www.readbyqxmd.com/read/27331657/cacna1h-missense-mutations-associated-with-amyotrophic-lateral-sclerosis-alter-cav3-2-t-type-calcium-channel-activity-and-reticular-thalamic-neuron-firing
#19
Yuriy Rzhepetskyy, Joanna Lazniewska, Iulia Blesneac, Roger Pamphlett, Norbert Weiss
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. In a recent study by Steinberg and colleagues, 2 recessive missense mutations were identified in the Cav3.2 T-type calcium channel gene (CACNA1H), in a family with an affected proband (early onset, long duration ALS) and 2 unaffected parents. We have introduced and functionally characterized these mutations using transiently expressed human Cav3.2 channels in tsA-201 cells...
November 2016: Channels
https://www.readbyqxmd.com/read/27304225/specificity-of-the-connexin-w3-4-locus-for-functional-gap-junction-formation
#20
Qin Xu, Xianming Lin, Arvydas Matiukas, Xian Zhang, Richard D Veenstra
The N-terminal (NT) domain of the connexins forms an essential transjunctional voltage (Vj) sensor and pore-forming domain that when truncated, tagged, or mutated often leads to formation of a nonfunctional channel. The NT domain is relatively conserved among the connexins though the α- and δ-group connexins possess a G2 residue not found in the β- and γ-group connexins. Deletion of the connexin40 G2 residue (Cx40G2Δ) affected the Vj gating, increased the single channel conductance (γj), and decreased the relative K(+)/Cl(-) permeability (PK/PCl) ratio of the Cx40 gap junction channel...
November 2016: Channels
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