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https://www.readbyqxmd.com/read/28418760/aromatic-dipeptide-trp-ala-can-be-transported-by-arabidopsis-peptide-transporters-atptr1-and-atptr5
#1
Diyang Qiu, Rui Hu, Ying Li, Mingyong Zhang
Dipeptides with an aromatic residue at the N-terminal position induced lower inward currents or blocked leak currents in Xenopus oocytes expressing the proton-coupled peptide transporter AtPTR1 or AtPTR5 of Arabidopsis thaliana compared with dipeptides with an aromatic residue at the C-terminal position. Here, AtPTR1 and AtPTR5 were expressed in a yeast mutant of peptide transporter (ptr2) with tryptophan auxotrophy. Growth assays showed that Trp-Ala could be transported by both AtPTR1 and AtPTR5 as efficiently as Ala-Trp...
April 18, 2017: Channels
https://www.readbyqxmd.com/read/28399685/pico145-powerful-new-tool-for-trpc1-4-5-channels
#2
Hussein N Rubaiy, Melanie J Ludlow, Robin S Bon, David J Beech
No abstract text is available yet for this article.
April 11, 2017: Channels
https://www.readbyqxmd.com/read/28340331/sumo-on-crmps-wrestling-for-pain
#3
Anne Baumann, Petri Kursula
No abstract text is available yet for this article.
March 24, 2017: Channels
https://www.readbyqxmd.com/read/28319451/a-best-example-of-channel-structure-annotation-by-molecular-simulation
#4
Shanlin Rao, Gianni Klesse, Phillip J Stansfeld, Stephen J Tucker, Mark S P Sansom
An increasing number of ion channel structures are being determined. This generates a need for computational tools to enable functional annotation of channel structures. However, a number of studies of ion channel and model pores have indicated that the physical dimensions of a pore are not always a reliable indicator of its conductive status. This is due to the unusual behavior of water within nano-confined spaces, resulting in a phenomenon referred to as 'hydrophobic gating'. We have recently demonstrated how simulating the behavior of water within an ion channel pore can be used to predict its conductive status...
March 20, 2017: Channels
https://www.readbyqxmd.com/read/28301277/evidence-that-orai1-does-not-contribute-to-store-operated-trpc1-channels-in-vascular-smooth-muscle-cells
#5
Jian Shi, Francesc Miralles, Jean-Pierre Kinet, Lutz Birnbaumer, William A Large, Anthony P Albert
Ca(2+)-permeable store-operated channels (SOCs) mediate Ca(2+) entry pathways which are involved in many cellular functions such as contraction, growth, and proliferation. Prototypical SOCs are formed of Orai1 proteins and are activated by the endo/sarcoplasmic reticulum Ca(2+) sensor stromal interaction molecule 1 (STIM1). There is considerable debate about whether canonical transient receptor potential 1 (TRPC1) proteins also form store-operated channels (SOCs), and if they do, is Orai1 involved. We recently showed that stimulation of TRPC1-based SOCs involves store depletion inducing STIM1-evoked Gαq/PLCβ1 activity in contractile vascular smooth muscle cells (VSMCs)...
March 16, 2017: Channels
https://www.readbyqxmd.com/read/28301269/the-long-tale-of-the-calcium-activated-cl-channels-in-olfactory-transduction
#6
Michele Dibattista, Simone Pifferi, Anna Boccaccio, Anna Menini, Johannes Reisert
Ca(2+)-activated Cl(-) currents have been implicated in many cellular processes in different cells, but for many years, their molecular identity remained unknown. Particularly intriguing are Ca(2+)-activated Cl(-) currents in olfactory transduction, first described in the early 90s. Well characterized electrophysiologically, they carry most of the odorant-induced receptor current in the cilia of olfactory sensory neurons (OSNs). After many attempts to determine their molecular identity, TMEM16B was found to be abundantly expressed in the cilia of OSNs in 2009 and having biophysical properties like those of the native olfactory channel...
March 16, 2017: Channels
https://www.readbyqxmd.com/read/28287333/dependence-of-heat-evoked-trpa1-activation-on-extracellular-ca-2
#7
Erkin Kurganov, Makoto Tominaga
No abstract text is available yet for this article.
March 13, 2017: Channels
https://www.readbyqxmd.com/read/28282251/divide-multitask-and-conquer-coordination-in-channel-regulation
#8
Juan Lorenzo Pablo, Geoffrey S Pitt
No abstract text is available yet for this article.
March 2, 2017: Channels
https://www.readbyqxmd.com/read/28277939/potassium-channel-expression-and-function-in-microglia-plasticity-and-possible-species-variations
#9
Hai M Nguyen, Linda V Blomster, Palle Christophersen, Heike Wulff
Potassium channels play important roles in microglia functions and thus constitute potential targets for the treatment of neurodegenerative diseases like Alzheimer, Parkinson and stroke. However, uncertainty still prevails as to which potassium channels are expressed and at what levels in different species, how the expression pattern changes upon activation with M1 or M2 polarizing stimuli compared with more complex exposure paradigms, and - most importantly - how these findings relate to the in vivo situation...
March 1, 2017: Channels
https://www.readbyqxmd.com/read/28277938/sk-channel-subtypes-enable-parallel-optimized-coding-of-behaviorally-relevant-stimulus-attributes-a-review
#10
Chengjie G Huang, Maurice J Chacron
Ion channels play essential roles toward determining how neurons respond to sensory input to mediate perception and behavior. Small conductance calcium-activated potassium (SK) channels are found ubiquitously throughout the brain and have been extensively characterized both molecularly and physiologically in terms of structure and function. It is clear that SK channels are key determinants of neural excitability as they mediate important neuronal response properties such as spike frequency adaptation. However, the functional roles of the different known SK channel subtypes are not well understood...
March 1, 2017: Channels
https://www.readbyqxmd.com/read/28277940/a-single-structurally-conserved-sumoylation-site-in-crmp2-controls-nav1-7-function
#11
Erik Thomas Dustrude, Samantha Perez-Miller, Liberty François-Moutal, Aubin Moutal, May Khanna, Rajesh Khanna
The neuronal collapsin response mediator protein 2 (CRMP2) undergoes several posttranslational modifications that codify its functions. Most recently, CRMP2 SUMOylation (addition of small ubiquitin like modifier (SUMO)) was identified as a key regulatory step within a modification program that codes for CRMP2 interaction with, and trafficking of, voltage-gated sodium channel NaV1.7. In this paper, we illustrate the utility of combining sequence alignment within protein families with structural analysis to identify, from several putative SUMOylation sites, those that are most likely to be biologically relevant...
February 28, 2017: Channels
https://www.readbyqxmd.com/read/28166450/channel-disassembled-pick-tweak-and-soak-parts-to-soften
#12
Andriy Anishkin, Sergei Sukharev
No abstract text is available yet for this article.
February 6, 2017: Channels
https://www.readbyqxmd.com/read/27960620/the-goslo-family-of-bk-channel-activators-a-no-go-for-%C3%AE-subunits
#13
Teresa Giraldez
No abstract text is available yet for this article.
March 4, 2017: Channels
https://www.readbyqxmd.com/read/27764579/specific-and-essential-but-not-sufficient-roles-of-lrrc8a-in-the-activity-of-volume-sensitive-outwardly-rectifying-anion-channel-vsor
#14
Toshiaki Okada, Md Rafiqul Islam, Nargiza A Tsiferova, Yasunobu Okada, Ravshan Z Sabirov
The broadly expressed volume-sensitive outwardly rectifying anion channel (VSOR, also called VRAC) plays essential roles in cell survival and death. Recent findings have suggested that LRRC8A is a core component of VSOR in human cells. In the present study, VSOR currents were found to be largely reduced by siRNA against LRRC8A in mouse C127 cells as well. In contrast, LRRC8A knockdown never affected activities of 4 other types of anion channel activated by acid, Ca(2+), patch excision or cAMP. While cisplatin-resistant KCP-4 cells poorly expressed endogenous VSOR activity, molecular expression levels of LRRC8A, LRRC8D and LRRC8E were indistinguishable between VSOR-deficient KCP-4 cells and the parental VSOR-rich KB cells...
March 4, 2017: Channels
https://www.readbyqxmd.com/read/27736292/orai1-regulates-calcium-entry-into-dendritic-spines
#15
Eduard Korkotian, Menahem Segal
No abstract text is available yet for this article.
March 4, 2017: Channels
https://www.readbyqxmd.com/read/27690717/the-glycosylation-of-the-extracellular-loop-of-%C3%AE-2-subunits-diversifies-functional-phenotypes-of-bk-channels
#16
Zhi-Gang Huang, Hao-Wen Liu, Zhen-Zhen Yan, Sheng Wang, Lu-Yang Wang, Jiu-Ping Ding
Large-conductance Ca(2+)- and voltage-activated potassium (MaxiK or BK) channels are composed of a pore-forming α subunit (Slo) and 4 types of auxiliary β subunits or just a pore-forming α subunit. Although multiple N-linked glycosylation sites in the extracellular loop of β subunits have been identified, very little is known about how glycosylation influences the structure and function of BK channels. Using a combination of site-directed mutagenesis, western blot and patch-clamp recordings, we demonstrated that 3 sites in the extracellular loop of β2 subunit are N-glycosylated (N-X-T/S at N88, N96 and N119)...
March 4, 2017: Channels
https://www.readbyqxmd.com/read/27689426/hysteresis-in-voltage-gated-channels
#17
Carlos A Villalba-Galea
Ion channels constitute a superfamily of membrane proteins found in all living creatures. Their activity allows fast translocation of ions across the plasma membrane down the ion's transmembrane electrochemical gradient, resulting in a difference in electrical potential across the plasma membrane, known as the membrane potential. A group within this superfamily, namely voltage-gated channels, displays activity that is sensitive to the membrane potential. The activity of voltage-gated channels is controlled by the membrane potential, while the membrane potential is changed by these channels' activity...
March 4, 2017: Channels
https://www.readbyqxmd.com/read/27657932/a-new-direction-for-spreading-depolarization-investigation-in-the-fly-brain
#18
Kristin E Spong, Jens P Dreier, R Meldrum Robertson
No abstract text is available yet for this article.
March 4, 2017: Channels
https://www.readbyqxmd.com/read/27653665/t-type-calcium-channels-in-synaptic-plasticity
#19
Nathalie Leresche, Régis C Lambert
The role of T-type calcium currents is rarely considered in the extensive literature covering the mechanisms of long-term synaptic plasticity. This situation reflects the lack of suitable T-type channel antagonists that till recently has hampered investigations of the functional roles of these channels. However, with the development of new pharmacological and genetic tools, a clear involvement of T-type channels in synaptic plasticity is starting to emerge. Here, we review a number of studies showing that T-type channels participate to numerous homo- and hetero-synaptic plasticity mechanisms that involve different molecular partners and both pre- and post-synaptic modifications...
March 4, 2017: Channels
https://www.readbyqxmd.com/read/27579940/distinct-contributions-of-lrrc8a-and-its-paralogs-to-the-vsor-anion-channel-from-those-of-the-asor-anion-channel
#20
Kaori Sato-Numata, Tomohiro Numata, Ryuji Inoue, Ravshan Z Sabirov, Yasunobu Okada
Volume- and acid-sensitive outwardly rectifying anion channels (VSOR and ASOR) activated by swelling and acidification exhibit voltage-dependent inactivation and activation time courses, respectively. Recently, LRRC8A and some paralogs were shown to be essentially involved in the activity and inactivation kinetics of VSOR currents in human colonic HCT116 cells. In human cervix HeLa cells, here, inactivation of VSOR currents was found to become accelerated by RNA silencing only of LRRC8A but never decelerated by that of any LRRC8 isoform...
March 4, 2017: Channels
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