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https://www.readbyqxmd.com/read/29589519/dopamine-mediated-calcium-channel-regulation-in-synaptic-suppression-in-l-stagnalis-interneurons
#1
Nancy Dong, David W K Lee, Hong-Shuo Sun, Zhong-Ping Feng
D2 dopamine receptor-mediated suppression of synaptic transmission from interneurons plays a key role in neurobiological functions across species, ranging from respiration to memory formation. In this study, we investigated the mechanisms of D2 receptor-dependent suppression using soma-soma synapse between respiratory interneuron VD4 and LPeD1 in the mollusk Lymnaea stagnalis (L. stagnalis). We studied the effects of dopamine on voltage-dependent Ca2+ current and synaptic vesicle release from the VD4 neuron...
March 28, 2018: Channels
https://www.readbyqxmd.com/read/29589513/x-ray-crystallography-of-trp-channels
#2
Appu K Singh, Luke L McGoldrick, Kei Saotome, Alexander I Sobolevsky
Transient receptor potential (TRP) ion channels are molecular sensors of a large variety of stimuli including temperature, mechanical stress, voltage, small molecules including capsaicin and menthol, and lipids such as phosphatidylinositol 4,5-bisphosphate (PIP2 ). Since the same TRP channels may respond to different physical and chemical stimuli, they can serve as signal integrators. Many TRP channels are calcium permeable and contribute to Ca2+ homeostasis and signaling. Although the TRP channel family was discovered decades ago, only recently have the structures of many of these channels been solved, largely by cryo-electron microscopy (cryo-EM)...
March 28, 2018: Channels
https://www.readbyqxmd.com/read/29577810/pharmacologic-targeting-of-endothelial-ca-2-activated-k-channels-a-strategy-to-improve-cardiovascular-function
#3
Cini Mathew John, Rayan Khaddaj Mallat, Grace George, Taeyeob Kim, Ramesh C Mishra, Andrew P Braun
Endothelial small and intermediate-conductance, Ca2+ -activated K+ channels (KCa2.3 and KCa3.1, respectively) play an important role in the regulation of vascular function and systemic blood pressure. Growing evidence indicates that they are intimately involved in agonist-evoked vasodilation of small resistance arteries throughout the circulation. Small molecule activators of KCa2.x and 3.1 channels, such as SKA-31, can acutely inhibit myogenic tone in isolated resistance arteries, induce effective vasodilation in intact vascular beds, such as the coronary circulation, and acutely decrease systemic blood pressure in vivo...
March 26, 2018: Channels
https://www.readbyqxmd.com/read/29560783/trpc6-and-trpc4-heteromultimerization-mediates-store-depletion-activated-ncx1-reversal-in-proliferative-vascular-smooth-muscle-cells
#4
Bin Zhang, Bei Liu, Carolyn M Roos, Michael A Thompson, Y S Prakash, Jordan D Miller, Rui-Wei Guo
Store depletion has been shown to induce Ca2+ entry by Na+/Ca+ exchange (NCX) 1 reversal in proliferative vascular smooth muscle cells (VSMCs). The study objective was to investigate the role of transient receptor potential canonical (TRPC) channels in store depletion and NCX1 reversal in proliferative VSMCs. In cultured VSMCs, expressing TRPC1, TRPC4, and TRPC6, the removal of extracellular Na+ was followed by a significant increase of cytosolic Ca2+ concentration that was inhibited by KBR, a selective NCX1 inhibitor...
March 21, 2018: Channels
https://www.readbyqxmd.com/read/29532737/the-venom-of-ornithoctonus-huwena-affect-the-electrophysiological-stability-of-neonatal-rat-ventricular-myocytes-by-inhibiting-sodium-potassium-and-calcium-current
#5
Sha Yan, Pengfei Huang, Ying Wang, Xiongzhi Zeng, Yiya Zhang
Spider venoms are known to contain various toxins that are used as an effective means to capture their prey or to defend themselves against predators. An investigation of the properties of Ornithoctonus huwena (O.huwena) crude venom found that the venom can block neuromuscular transmission of isolated mouse phrenic nerve-diaphragm and sciatic nerve-sartorius preparations. However, little is known about its electrophysiological effects on cardiac myocytes. In this study, electrophysiological activities of ventricular myocytes were detected by 100 μg/mL venom of O...
January 1, 2018: Channels
https://www.readbyqxmd.com/read/29451064/inactivation-gating-of-kv7-1-channels-does-not-involve-concerted-cooperative-subunit-interactions
#6
Eshcar Meisel, William Tobelaim, Meidan Dvir, Yoni Haitin, Asher Peretz, Bernard Attali
Inactivation is an intrinsic property of numerous voltage-gated K+ (Kv) channels and can occur by N-type or/and C-type mechanisms. N-type inactivation is a fast, voltage independent process, coupled to activation, with each inactivation particle of a tetrameric channel acting independently. In N-type inactivation, a single inactivation particle is necessary and sufficient to occlude the pore. C-type inactivation is a slower process, involving the outermost region of the pore and is mediated by a concerted, highly cooperative interaction between all four subunits...
January 1, 2018: Channels
https://www.readbyqxmd.com/read/29424275/sensing-and-regulation-of-cell-volume-we-know-so-much-and-yet-understand-so-little-trpv4-as-a-sensor-of-volume-changes-but-possibly-without-a-volume-regulatory-role
#7
Trine L Toft-Bertelsen, Brian R Larsen, Nanna MacAulay
Cellular volume changes lead to initiation of cell volume regulatory events, the molecular identity of which remains unresolved. We here discuss experimental challenges associated with investigation of volume regulation during application of large, non-physiological osmotic gradients. The TRPV4 ion channel responds to volume increase irrespectively of the molecular mechanism underlying cell swelling, and is thus considered a sensor of volume changes. Evidence pointing towards the involvement of TRPV4 in subsequent volume regulatory mechanisms is intriguing, yet far from conclusive...
January 1, 2018: Channels
https://www.readbyqxmd.com/read/29380651/non-decaying-postsynaptics-potentials-and-delayed-spikes-in-hippocampal-pyramidal-neurons-generated-by-a-zero-slope-conductance-created-by-the-persistent-na-current
#8
Cesar C Ceballos, Rodrigo F O Pena, Antônio C Roque, Ricardo M Leão
The negative slope conductance created by the persistent sodium current (INaP ) prolongs the decay phase of excitatory postsynaptic potentials (EPSPs). In a recent study, we demonstrated that this effect was due to an increase of the membrane time constant. When the negative slope conductance opposes completely the positive slope conductances of the other currents it creates a zero slope conductance region. In this region the membrane time constant is infinite and the decay phase of the EPSPs is virtually absent...
January 1, 2018: Channels
https://www.readbyqxmd.com/read/29308980/modulation-of-trpa1-channel-activity-by-cdk5-in-sensory-neurons
#9
Michael A Sulak, Monica Ghosh, Pritam Sinharoy, Spencer R Andrei, Derek S Damron
Transient receptor potential cation channel, subfamily A, member 1 (TRPA1), is activated by a broad range of noxious stimuli. Cdk5, a member of the Cdk family, has recently been identified as a modulator of pain signaling pathways. In the current study, we investigated the extent to which Cdk5 modulates TRPA1 activity. Cdk5 inhibition was found to attenuate TRPA1 response to agonist in mouse DRG sensory neurons. Additionally, the presence of active Cdk5 was associated with increased TRPA1 phosphorylation in transfected HEK293 cells that was roscovitine-sensitive and absent in the mouse mutant S449A full-length channel...
January 1, 2018: Channels
https://www.readbyqxmd.com/read/29219667/endothelial-biology-and-atp-sensitive-potassium-channels
#10
Qadeer Aziz, Yiwen Li, Andrew Tinker
No abstract text is available yet for this article.
January 1, 2018: Channels
https://www.readbyqxmd.com/read/29179637/cone-dystrophy-and-ectopic-synaptogenesis-in-a-cacna1f-loss-of-function-model-of-congenital-stationary-night-blindness-csnb2a
#11
D M Waldner, N C Giraldo Sierra, S Bonfield, L Nguyen, I S Dimopoulos, Y Sauvé, W K Stell, N T Bech-Hansen
Congenital stationary night blindness 2A (CSNB2A) is an X-linked retinal disorder, characterized by phenotypically variable signs and symptoms of impaired vision. CSNB2A is due to mutations in CACNA1F, which codes for the pore-forming α1F subunit of a L-type voltage-gated calcium channel, Cav 1.4. Mouse models of CSNB2A, used for characterizing the effects of various Cacna1f mutations, have revealed greater severity of defects than in human CSNB2A. Specifically, Cacna1f-knockout mice show an apparent lack of visual function, gradual retinal degeneration, and disruption of photoreceptor synaptic terminals...
January 1, 2018: Channels
https://www.readbyqxmd.com/read/29168928/regulation-of-kv1-4-potassium-channels-by-pkc-and-ampk-kinases
#12
Martin Nybo Andersen, Lasse Skibsbye, Arnela Saljic, Martin Zahle Larsen, Hanne Borger Rasmussen, Thomas Jespersen
Over the last years extensive kinase-mediated regulation of a number of voltage-gated potassium (Kv) channels important in cardiac electrophysiology has been reported. This includes regulation of Kv1.5, Kv7.1 and Kv11.1 cell surface expression, where the kinase-mediated regulation appears to center around the ubiquitin ligase Nedd4-2. In the present study we examined whether Kv1.4, constituting the cardiac Ito,s current, is subject to similar regulation. In the epithelial Madin-Darby Canine Kidney (MDCK) cell line, which constitutes a highly reproducible model system for addressing membrane targeting, we find, by confocal microscopy, that Kv1...
January 1, 2018: Channels
https://www.readbyqxmd.com/read/29095109/pkc-and-calcium-channel-trafficking
#13
Franz Hofmann
No abstract text is available yet for this article.
January 1, 2018: Channels
https://www.readbyqxmd.com/read/29095086/trpm4-and-the-emperor
#14
J Marc Simard, Volodymyr Gerzanich
No abstract text is available yet for this article.
January 1, 2018: Channels
https://www.readbyqxmd.com/read/28991505/modulation-of-sk-channels-regulates-locomotor-alternating-bursting-activity-in-the-functionally-mature-spinal-cord
#15
Amr A Mahrous, Sherif M Elbasiouny
The spinal cord contains specialized groups of cells called pattern generators, which are capable of orchestrating rhythmic firing activity in an isolated preparation. Different patterns of activity could be generated in vitro including right-left alternating bursting and bursting in which both sides are synchronized. The cellular and network mechanisms that enable these behaviors are not fully understood. We have recently shown that Ca2+ -activated K+ channels (SK channels) control the initiation and amplitude of synchronized bursting in the spinal cord...
January 1, 2018: Channels
https://www.readbyqxmd.com/read/28985132/ent3-utilizes-a-ph-sensing-mechanism-for-transport
#16
Anusha Singh, Rajgopal Govindarajan
No abstract text is available yet for this article.
January 1, 2018: Channels
https://www.readbyqxmd.com/read/28976236/arrhythmogenic-triggers-associated-with-sudden-cardiac-death
#17
Mena Abdelsayed, Colin H Peters, Peter C Ruben
No abstract text is available yet for this article.
January 1, 2018: Channels
https://www.readbyqxmd.com/read/28961043/mechanistic-insight-into-the-suppression-of-microglial-ros-production-by-voltage-gated-proton-channels-vsop-hv1
#18
Takafumi Kawai, Shoki Tatsumi, Shinji Kihara, Kenji Sakimura, Yasushi Okamura
Voltage-gated proton channels (VSOP/Hv1) reportedly promote reactive oxygen species (ROS) production in several immune cell types. However, we recently reported that primary microglia from VSOP/Hv1-deficient mice show higher ROS production than those from WT mice. Microglia may show a distinct activation status between WT and VSOP/Hv1-deficient cells, leading to a distinct level of ROS production between them. This is unlikely, however, because ROS production in VSOP/Hv1-deficient microglia remained higher than in WT microglia when the cells were exposed to LPS...
January 1, 2018: Channels
https://www.readbyqxmd.com/read/28949795/characterization-of-ca-v-1-2-exon-33-heterozygous-knockout-mice-and-negative-correlation-between-rbfox1-and-ca-v-1-2-exon-33-expressions-in-human-heart-failure
#19
Juejin Wang, Guang Li, Dejie Yu, Yuk Peng Wong, Tan Fong Yong, Mui Cheng Liang, Ping Liao, Roger Foo, Uta C Hoppe, Tuck Wah Soong
Recently, we reported that homozygous deletion of alternative exon 33 of CaV 1.2 calcium channel in the mouse resulted in ventricular arrhythmias arising from increased CaV 1.2Δ33 ICaL current density in the cardiomyocytes. We wondered whether heterozygous deletion of exon 33 might produce cardiac phenotype in a dose-dependent manner, and whether the expression levels of RNA splicing factors known to regulate alternative splicing of exon 33 might change in human heart failure. Unexpectedly, we found that exon 33+/- cardiomyocytes showed similar CaV 1...
January 1, 2018: Channels
https://www.readbyqxmd.com/read/28837387/crmp2-is-necessary-for-neurofibromatosis-type-1-related-pain
#20
Aubin Moutal, Song Cai, Shizhen Luo, Raphaëlle Voisin, Rajesh Khanna
Neurofibromatosis type 1 (NF1) is one of the most common genetic diseases, affecting roughly 1 in 3000 individuals. As a multisystem disorder, it affects cognitive development, as well as bone, nerve and muscle constitution. Peripheral neuropathy in NF1 constitutes a potentially severe clinical complication and is associated with increased morbidity and mortality. The discovery of effective therapies for Neurofibromatosis type 1 (NF1) pain depends on mechanistic understanding that has been limited, in part, by the relative lack of availability of animal models relevant to NF1 pain...
January 1, 2018: Channels
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