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https://www.readbyqxmd.com/read/28340331/sumo-on-crmps-wrestling-for-pain
#1
Anne Baumann, Petri Kursula
No abstract text is available yet for this article.
March 24, 2017: Channels
https://www.readbyqxmd.com/read/28319451/a-best-example-of-channel-structure-annotation-by-molecular-simulation
#2
Shanlin Rao, Gianni Klesse, Phillip J Stansfeld, Stephen J Tucker, Mark S P Sansom
An increasing number of ion channel structures are being determined. This generates a need for computational tools to enable functional annotation of channel structures. However, a number of studies of ion channel and model pores have indicated that the physical dimensions of a pore are not always a reliable indicator of its conductive status. This is due to the unusual behavior of water within nano-confined spaces, resulting in a phenomenon referred to as 'hydrophobic gating'. We have recently demonstrated how simulating the behavior of water within an ion channel pore can be used to predict its conductive status...
March 20, 2017: Channels
https://www.readbyqxmd.com/read/28301277/evidence-that-orai1-does-not-contribute-to-store-operated-trpc1-channels-in-vascular-smooth-muscle-cells
#3
Jian Shi, Francesc Miralles, Jean-Pierre Kinet, Lutz Birnbaumer, William A Large, Anthony P Albert
Ca(2+)-permeable store-operated channels (SOCs) mediate Ca(2+) entry pathways which are involved in many cellular functions such as contraction, growth, and proliferation. Prototypical SOCs are formed of Orai1 proteins and are activated by the endo/sarcoplasmic reticulum Ca(2+) sensor stromal interaction molecule 1 (STIM1). There is considerable debate about whether canonical transient receptor potential 1 (TRPC1) proteins also form store-operated channels (SOCs), and if they do, is Orai1 involved. We recently showed that stimulation of TRPC1-based SOCs involves store depletion inducing STIM1-evoked Gαq/PLCβ1 activity in contractile vascular smooth muscle cells (VSMCs)...
March 16, 2017: Channels
https://www.readbyqxmd.com/read/28301269/the-long-tale-of-the-calcium-activated-cl-channels-in-olfactory-transduction
#4
Michele Dibattista, Simone Pifferi, Anna Boccaccio, Anna Menini, Johannes Reisert
Ca(2+)-activated Cl(-) currents have been implicated in many cellular processes in different cells, but for many years, their molecular identity remained unknown. Particularly intriguing are Ca(2+)-activated Cl(-) currents in olfactory transduction, first described in the early 90s. Well characterized electrophysiologically, they carry most of the odorant-induced receptor current in the cilia of olfactory sensory neurons (OSNs). After many attempts to determine their molecular identity, TMEM16B was found to be abundantly expressed in the cilia of OSNs in 2009 and having biophysical properties like those of the native olfactory channel...
March 16, 2017: Channels
https://www.readbyqxmd.com/read/28287333/dependence-of-heat-evoked-trpa1-activation-on-extracellular-ca-2
#5
Erkin Kurganov, Makoto Tominaga
No abstract text is available yet for this article.
March 13, 2017: Channels
https://www.readbyqxmd.com/read/28282251/divide-multitask-and-conquer-coordination-in-channel-regulation
#6
Juan Lorenzo Pablo, Geoffrey S Pitt
No abstract text is available yet for this article.
March 2, 2017: Channels
https://www.readbyqxmd.com/read/28277939/potassium-channel-expression-and-function-in-microglia-plasticity-and-possible-species-variations
#7
Hai M Nguyen, Linda V Blomster, Palle Christophersen, Heike Wulff
Potassium channels play important roles in microglia functions and thus constitute potential targets for the treatment of neurodegenerative diseases like Alzheimer, Parkinson and stroke. However, uncertainty still prevails as to which potassium channels are expressed and at what levels in different species, how the expression pattern changes upon activation with M1 or M2 polarizing stimuli compared with more complex exposure paradigms, and - most importantly - how these findings relate to the in vivo situation...
March 1, 2017: Channels
https://www.readbyqxmd.com/read/28277938/sk-channel-subtypes-enable-parallel-optimized-coding-of-behaviorally-relevant-stimulus-attributes-a-review
#8
Chengjie G Huang, Maurice J Chacron
Ion channels play essential roles toward determining how neurons respond to sensory input to mediate perception and behavior. Small conductance calcium-activated potassium (SK) channels are found ubiquitously throughout the brain and have been extensively characterized both molecularly and physiologically in terms of structure and function. It is clear that SK channels are key determinants of neural excitability as they mediate important neuronal response properties such as spike frequency adaptation. However, the functional roles of the different known SK channel subtypes are not well understood...
March 1, 2017: Channels
https://www.readbyqxmd.com/read/28277940/a-single-structurally-conserved-sumoylation-site-in-crmp2-controls-nav1-7-function
#9
Erik Thomas Dustrude, Samantha Perez-Miller, Liberty François-Moutal, Aubin Moutal, May Khanna, Rajesh Khanna
The neuronal collapsin response mediator protein 2 (CRMP2) undergoes several posttranslational modifications that codify its functions. Most recently, CRMP2 SUMOylation (addition of small ubiquitin like modifier (SUMO)) was identified as a key regulatory step within a modification program that codes for CRMP2 interaction with, and trafficking of, voltage-gated sodium channel NaV1.7. In this paper, we illustrate the utility of combining sequence alignment within protein families with structural analysis to identify, from several putative SUMOylation sites, those that are most likely to be biologically relevant...
February 28, 2017: Channels
https://www.readbyqxmd.com/read/28166450/channel-disassembled-pick-tweak-and-soak-parts-to-soften
#10
Andriy Anishkin, Sergei Sukharev
No abstract text is available yet for this article.
February 6, 2017: Channels
https://www.readbyqxmd.com/read/28121479/cisplatin-activates-volume-sensitive-lrrc8-channel-mediated-currents-in-xenopus-oocytes
#11
Antonella Gradogna, Héctor Gaitán-Peñas, Anna Boccaccio, Raúl Estévez, Michael Pusch
LRRC8 proteins have been shown to underlie the ubiquitous volume regulated anion channel (VRAC). VRAC channels are composed of the LRRC8A subunit and at least one among the LRRC8B-E subunits. In addition to their role in volume regulation, LRRC8 proteins have been implicated in the uptake of chemotherapeutic agents. We had found that LRRC8 channels can be conveniently expressed in Xenopus oocytes, a system without endogenous VRAC activity. The fusion with fluorescent proteins yielded constitutive activity for A/C, A/D and A/E heteromers...
January 25, 2017: Channels
https://www.readbyqxmd.com/read/28118079/sugar-and-spice-and-potassium-channel-modulation
#12
Irwin B Levitan
No abstract text is available yet for this article.
January 24, 2017: Channels
https://www.readbyqxmd.com/read/28102743/expression-and-alteration-of-bkca-channels-in-the-sphincter-of-oddi-s-from-rabbits-with-hypercholesterolemia
#13
Dan Feng, Haiyan Nan, Wen Wang, Linfeng Yan, Pang Du, Lin Zuo, Kun Zhang, Minggao Zhao, Guangbin Cui
This study aimed to investigate the expression and function of BKCa channels in the Sphincter of Oddi (SO) in a rabbit model of hypercholesterolemia (HC). New Zealand white rabbits were randomly divided into 2 groups: the control group was fed standard chow (n = 18) whereas the high-cholesterol group was fed cholesterol-enriched chow containing 1.5% cholesterol (n = 18). The serum cholesterol level was significantly greater in the HC groups than in the control group, but there was no significant difference in body weight between the control and HC groups...
January 19, 2017: Channels
https://www.readbyqxmd.com/read/28085630/mechanosensitive-ion-channel-piezo2-is-inhibited-by-d-gsmtx4
#14
Constanza Alcaino, Kaitlyn Knutson, Philip A Gottlieb, Gianrico Farrugia, Arthur Beyder
Enterochromaffin (EC) cells are the primary mechanosensors of the gastrointestinal (GI) epithelium. In response to mechanical stimuli EC cells release serotonin (5-hydroxytryptamine; 5-HT). The molecular details of EC cell mechanosensitivity are poorly understood. Recently, our group found that human and mouse EC cells express the mechanosensitive ion channel Piezo2. The mechanosensitive currents in a human EC cell model QGP-1 were blocked by the mechanosensitive channel blocker D-GsMTx4. In the present study we aimed to characterize the effects of the mechanosensitive ion channel inhibitor spider peptide D-GsMTx4 on the mechanically stimulated currents from both QGP-1 and human Piezo2 transfected HEK-293 cells...
January 13, 2017: Channels
https://www.readbyqxmd.com/read/28085542/involvement-of-intracellular-transport-in-trek-1c-current-run-up-in-293t-cells
#15
Naaz Andharia, Ancy Joseph, Mikio Hayashi, Masayoshi Okada, Hiroko Matsuda
The TREK-1 channel, the TWIK-1-related potassium (K(+)) channel, is a member of a family of two-pore-domain K(+) (K2P) channels, through which background or leak K(+) currents occur. An interesting feature of the TREK-1 channel is the run-up of current: i.e. the current through TREK-1 channels spontaneously increases within several minutes of the formation of the whole-cell configuration. To investigate whether intracellular transport is involved in the run-up, we established 293T cell lines stably expressing the TREK-1c channel (K2P2...
January 13, 2017: Channels
https://www.readbyqxmd.com/read/28055302/t-type-ca-2-channels-and-autoregulation-of-local-blood-flow
#16
Lars Jørn Jensen, Morten Schak Nielsen, Max Salomonsson, Charlotte Mehlin Sørensen
L-type voltage gated Ca(2+) channels are considered to be the primary source of calcium influx during the myogenic response. However, many vascular beds also express T-type voltage gated Ca(2+) channels. Recent studies suggest that these channels may also play a role in autoregulation. At low pressures (40-80 mmHg) T-type channels affect myogenic responses in cerebral and mesenteric vascular beds. T-type channels also seem to be involved in skeletal muscle autoregulation. This review discusses the expression and role of T-type voltage gated Ca(2+) channels in the autoregulation of several different vascular beds...
January 5, 2017: Channels
https://www.readbyqxmd.com/read/27682595/stacking-up-cav3-2-channels
#17
Mircea C Iftinca, Christophe Altier
No abstract text is available yet for this article.
January 2, 2017: Channels
https://www.readbyqxmd.com/read/27588459/gdp-l-fucose-transport-in-plants-the-missing-piece
#18
Berit Ebert, Carsten Rautengarten, Joshua L Heazlewood
No abstract text is available yet for this article.
January 2, 2017: Channels
https://www.readbyqxmd.com/read/27540685/styrax-blocks-inward-and-outward-current-of-kir2-1-channel
#19
Shuxi Ren, Chunli Pang, Junwei Li, Yayue Huang, Suhua Zhang, Yong Zhan, Hailong An
Kir2.1 plays key roles in setting rest membrane potential and modulation of cell excitability. Mutations of Kir2.1, such as D172N or E299V, inducing gain-of-function, can cause type3 short QT syndrome (SQT3) due to the enlarged outward currents. So far, there is no clinical drug target to block the currents of Kir2.1. Here, we identified a novel blocker of Kir2.1, styrax, which is a kind of natural compound selected from traditional Chinese medicine. Our data show that styrax can abolish the inward and outward currents of Kir2...
January 2, 2017: Channels
https://www.readbyqxmd.com/read/27440457/differential-efficacy-of-goslo-sr-compounds-on-bk%C3%AE-and-bk%C3%AE-%C3%AE-1-4-channels
#20
Aravind S Kshatri, Qin Li, Jiusheng Yan, Roddy J Large, Gerard P Sergeant, Noel G McHale, Keith D Thornbury, Mark A Hollywood
Large conductance, voltage and Ca(2+) activated K(+) channels (BK channels) are abundantly expressed throughout the body and are important regulators of smooth muscle tone and neuronal excitability. Their dysfunction is implicated in various diseases including overactive bladder, hypertension and erectile dysfunction. Therefore, BK channel openers bear significant therapeutic potential to treat the above diseases. GoSlo-SR compounds were designed to be potent and efficacious BK channel openers. Although their structural activity relationships, activation in both BKα and BKαβ channels and the hypothetical mode of action of these compounds has been studied in detail in recent years, their effectiveness to open the BKαγ channels still remains unexplored...
January 2, 2017: Channels
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