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https://www.readbyqxmd.com/read/29130788/complex-action-of-tyramine-tryptamine-and-histamine-on-native-and-recombinant-asics
#1
Oleg I Barygin, Margarita S Komarova, Tatyana B Tikhonova, Anastasiia S Korosteleva, Maxim V Nikolaev, Lev G Magazanik, Denis B Tikhonov
Proton-gated channels of the ASIC family are widely distributed in the mammalian brain, and, according to the recent data, participate in synaptic transmission. However, ASIC-mediated currents are small, and special efforts are required to detect them. This prompts the search for endogenous ASIC ligands, which can activate or potentiate these channels. A recent finding of the potentiating action of histamine on recombinant homomeric ASIC1a has directed attention to amine-containing compounds. In the present study, we have analyzed the action of histamine, tyramine, and tryptamine on native and recombinant ASICs...
November 13, 2017: Channels
https://www.readbyqxmd.com/read/29095109/pkc-and-calcium-channel-trafficking
#2
Franz Hofmann
No abstract text is available yet for this article.
November 2, 2017: Channels
https://www.readbyqxmd.com/read/29095093/conservation-and-variability-of-the-pore-lining-helices-in-p-loop-channels
#3
Denis B Tikhonov, Boris S Zhorov
The family of P-loop channels, which play key roles in the cell physiology, is characterized by four membrane re-entering extracellular P-loops that connect eight transmembrane helices of the pore-forming domain. The X-ray and cryo-EM structures of the open- and closed-state channels show conserved state-dependent folding despite the sequences are very diverse. In sodium, calcium, TRPV and two-pore channels, the pore-lining helices contain conserved asparagines and may or may not include π-helix bulges. Comparison of the sequence- and 3D-alignemnts suggests that the asparagines appeared in evolution as insertions that are accommodated in two ways: by π-helix bulges, which preserve most of inter-segment contacts, or by twists of the C-terminal thirds and switch of inter-segment contacts...
November 2, 2017: Channels
https://www.readbyqxmd.com/read/29095086/trpm4-and-the-emperor
#4
J Marc Simard, Volodymyr Gerzanich
No abstract text is available yet for this article.
November 2, 2017: Channels
https://www.readbyqxmd.com/read/29087246/a-new-familial-form-of-a-late-onset-persistent-hyperinsulinemic-hypoglycemia-of-infancy-caused-by-a-novel-mutation-in-kcnj11
#5
Yen-Yu Yang, Roger Long, Christine Ferrara, Stephen Gitelman, Michael German, Shi-Bing Yang
The ATP-sensitive potassium channel (KATP) functions as a metabo-electric transducer in regulating insulin secretion from pancreatic β-cells. The pancreatic KATP channel is composed of a pore-forming inwardly-rectifying potassium channel, Kir6.2, and a regulatory subunit, sulphonylurea receptor 1 (SUR1). Loss-of-function mutations in either subunit often lead to the development of persistent hyperinsulinemic hypoglycemia of infancy (PHHI). PHHI is a rare genetic disease and most patients present with immediate onset within the first few days after birth...
October 31, 2017: Channels
https://www.readbyqxmd.com/read/28991505/modulation-of-sk-channels-regulates-locomotor-alternating-bursting-activity-in-the-functionally-mature-spinal-cord
#6
Amr A Mahrous, Sherif M Elbasiouny
The spinal cord contains specialized groups of cells called pattern generators, which are capable of orchestrating rhythmic firing activity in an isolated preparation. Different patterns of activity could be generated in vitro including right-left alternating bursting and bursting in which both sides are synchronized. The cellular and network mechanisms that enable these behaviors are not fully understood. We have recently shown that Ca(2+)-activated K(+) channels (SK channels) control the initiation and amplitude of synchronized bursting in the spinal cord...
October 9, 2017: Channels
https://www.readbyqxmd.com/read/28985132/ent3-utilizes-a-ph-sensing-mechanism-for-transport
#7
Anusha Singh, Rajgopal Govindarajan
No abstract text is available yet for this article.
October 6, 2017: Channels
https://www.readbyqxmd.com/read/28976808/ca-2-calmodulin-and-pip2-interactions-at-the-proximal-c-terminus-of-kv7-channels
#8
William S Tobelaim, Meidan Dvir, Guy Lebel, Meng Cui, Tal Buki, Asher Peretz, Milit Marom, Yoni Haitin, Diomedes E Logothetis, Joel A Hirsch, Bernard Attali
In the heart, co-assembly of Kv7.1 with KCNE1 produces the slow IKS potassium current, which repolarizes the cardiac action potential and mutations in human Kv7.1 and KCNE1 genes cause cardiac arrhythmias. The proximal Kv7.1 C-terminus binds calmodulin (CaM) and phosphatidylinositol-4,5-bisphosphate (PIP2) and recently we revealed the competition of PIP2 with the calcified CaM N-lobe to a previously unidentified site in Kv7.1 helix B, also known to harbor a LQT mutation. Data indicated that PIP2 and Ca(2+)-CaM perform the same function on IKS channel gating to stabilize the channel open state...
October 4, 2017: Channels
https://www.readbyqxmd.com/read/28976236/arrhythmogenic-triggers-associated-with-sudden-cardiac-death
#9
Mena Abdelsayed, Colin H Peters, Peter C Ruben
No abstract text is available yet for this article.
October 4, 2017: Channels
https://www.readbyqxmd.com/read/28961043/mechanistic-insight-into-the-suppression-of-microglial-ros-production-by-voltage-gated-proton-channels-vsop-hv1
#10
Takafumi Kawai, Shoki Tatsumi, Shinji Kihara, Kenji Sakimura, Yasushi Okamura
Voltage-gated proton channels (VSOP/Hv1) reportedly promote reactive oxygen species (ROS) production in several immune cell types. However, we recently reported that primary microglia from VSOP/Hv1-deficient mice show higher ROS production than those from WT mice. Microglia may show a distinct activation status between WT and VSOP/Hv1-deficient cells, leading to a distinct level of ROS production between them. This is unlikely, however, because ROS production in VSOP/Hv1-deficient microglia remained higher than in WT microglia when the cells were exposed to LPS...
September 29, 2017: Channels
https://www.readbyqxmd.com/read/28949795/characterization-of-cav1-2-exon-33-heterozygous-knockout-mice-and-negative-correlation-between-rbfox1-and-cav1-2-exon-33-expressions-in-human-heart-failure
#11
Juejin Wang, Guang Li, Dejie Yu, Yuk Peng Wong, Tan Fong Yong, Mui Cheng Liang, Ping Liao, Roger Foo, Uta C Hoppe, Tuck Wah Soong
Recently, we reported that homozygous deletion of alternative exon 33 of CaV1.2 calcium channel in the mouse resulted in ventricular arrhythmias arising from increased CaV1.2Δ33 ICaL current density in the cardiomyocytes. We wondered whether heterozygous deletion of exon 33 might produce cardiac phenotype in a dose-dependent manner, and whether the expression levels of RNA splicing factors known to regulate alternative splicing of exon 33 might change in human heart failure. Unexpectedly, we found that exon 33(+/-) cardiomyocytes showed similar CaV1...
September 26, 2017: Channels
https://www.readbyqxmd.com/read/28933647/identification-of-regions-responsible-for-the-function-of-the-plant-k-channels-kat1-and-akt2-in-saccharomyces-cerevisiae-and-xenopus-laevis-oocytes
#12
Shunya Saito, Naomi Hoshi, Lalu Zulkifli, Sri Widyastuti, Shinobu Goshima, Ingo Dreyer, Nobuyuki Uozumi
The Arabidopsis K(+) channel KAT1 complements in K(+)-limited medium the growth of the K(+) uptake defective Saccharomyces cerevisiae mutant strain CY162, while another K(+) channel, AKT2, does not. To gain insight into the structural basis for this difference, we constructed 12 recombinant chimeric channels from these two genes. When expressed in CY162, only three of these chimeras fully rescued the growth of CY162 under K(+)-limited conditions. We conclude that the transmembrane core region of KAT1 is important for its activity in S...
September 21, 2017: Channels
https://www.readbyqxmd.com/read/28922053/distribution-and-function-of-voltage-gated-sodium-channels-in-the-nervous-system
#13
Jun Wang, Shao-Wu Ou, Yun-Jie Wang
Voltage-gated sodium channels (VGSCs) are the basic ion channels for neuronal excitability, which are crucial for the resting potential and the generation and propagation of action potentials in neurons. To date, at least nine distinct sodium channel isoforms have been detected in the nervous system. Recent studies have identified that voltage-gated sodium channels not only play an essential role in the normal electrophysiological activities of neurons but also have a close relationship with neurological diseases...
September 18, 2017: Channels
https://www.readbyqxmd.com/read/28901828/protein-kinase-c-enhances-plasma-membrane-expression-of-cardiac-l-type-calcium-channel-cav1-2
#14
Tal Keren Raifman, Prabodh Kumar, Hannelore Haase, Enno Klussmann, Nathan Dascal, Sharon Weiss
L-type-voltage-dependent Ca(2+) channels (L-VDCCs; CaV1.2, α1C), crucial in cardiovascular physiology and pathology, are modulated via activation of G-protein-coupled receptors and subsequently protein kinase C (PKC). Despite extensive study, key aspects of the mechanisms leading to PKC-induced Ca(2+) current increase are unresolved. A notable residue, Ser1928, located in the distal C-terminus (dCT) of α1C was shown to be phosphorylated by PKC. CaV1.2 undergoes posttranslational modifications yielding full-length and proteolytically cleaved CT-truncated forms...
September 13, 2017: Channels
https://www.readbyqxmd.com/read/28876978/are-there-superagonists-for-calcium-activated-potassium-channels
#15
Brandon M Brown, Heesung Shim, Heike Wulff
No abstract text is available yet for this article.
September 6, 2017: Channels
https://www.readbyqxmd.com/read/28876976/trpm4-activation-by-chemically-and-oxygen-deprivation-induced-ischemia-and-reperfusion-triggers-neuronal-death
#16
Elías Leiva-Salcedo, Denise Riquelme, Oscar Cerda, Andrés Stutzin
Cerebral ischemia-reperfusion injury triggers a deleterious process ending in neuronal death. This process has two components, a glutamate-dependent and a glutamate-independent mechanism. In the glutamate-independent mechanism, neurons undergo a slow depolarization eventually leading to neuronal death. However, little is known about the molecules that take part in this process. Here we show by using mice cortical neurons in culture and ischemia-reperfusion protocols that TRPM4 is fundamental for the glutamate-independent neuronal damage...
September 6, 2017: Channels
https://www.readbyqxmd.com/read/28876960/trpm2-shredding-the-mitochondrial-network
#17
Fangfang Li, Nada Abuarab, Asipu Sivaprasadarao
No abstract text is available yet for this article.
September 6, 2017: Channels
https://www.readbyqxmd.com/read/28873008/induction-of-adipose-and-hepatic-swell1-expression-is-required-for-maintaining-systemic-insulin-sensitivity-in-obesity
#18
Litao Xie, Yanhui Zhang, Susheel K Gunasekar, Anil Mishra, Lei Cao, Rajan Sah
Obesity is associated with a loss of insulin-sensitivity and systemic dysglycemia, resulting in Type 2 diabetes, however the molecular mechanisms underlying this association are unclear. Through adipocyte patch-clamp studies, we recently showed that SWELL1 is required for the Volume-Regulated Anion Current (VRAC) in adipocytes and that SWELL1-mediated VRAC is activated by both mechanical and pathophysiological adipocyte expansion. We also demonstrated that adipocyte SWELL1 is required for maintaining insulin signaling and glucose homeostasis, particularly in the setting of obesity...
September 5, 2017: Channels
https://www.readbyqxmd.com/read/28837400/80pkc-sumoylation-inhibits-the-binding-of-14-3-3%C3%AF-to-gluk2
#19
Xiaoling Li, Yan Wang, Aoxue Zhu, Jie Zhou, Yong Li
Phosphorylation and SUMOylation of the kainate receptor (KAR) subunit GluK2 have been shown to regulate KAR surface expression, trafficking and synaptic plasticity. In addition, our previous study has shown that a phosphorylation-dependent interaction of 14-3-3τ and GluK2a-containing receptors contributes to the slow decay kinetics of native KAR-EPSCs. However, it is unknown whether SUMOylation participates in the regulation of the interaction between 14-3-3τ and GluK2a-containing receptors. Here we report that SUMOylation of PKC, but not GluK2, represses the binding of 14-3-3τ to GluK2a via decreasing the phosphorylation level of GluK2a...
August 24, 2017: Channels
https://www.readbyqxmd.com/read/28837387/crmp2-is-necessary-for-neurofibromatosis-type-1-related-pain
#20
Aubin Moutal, Song Cai, Shizhen Luo, Raphaëlle Voisin, Rajesh Khanna
Neurofibromatosis type 1 (NF1) is one of the most common genetic diseases, affecting roughly 1 in 3000 individuals. As a multisystem disorder, it affects cognitive development, as well as bone, nerve and muscle constitution. Peripheral neuropathy in NF1 constitutes a potentially severe clinical complication and is associated with increased morbidity and mortality. The discovery of effective therapies for Neurofibromatosis type 1 (NF1) pain depends on mechanistic understanding that has been limited, in part, by the relative lack of availability of animal models relevant to NF1 pain...
August 24, 2017: Channels
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