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https://www.readbyqxmd.com/read/28723241/the-effects-of-stretch-activation-on-ionic-selectivity-of-the-trek-2-k2p-k-channel
#1
Ehsan Nematian-Ardestani, Viwan Jarerattanachat, Prafulla Aryal, Mark S P Sansom, Stephen J Tucker
The TREK-2 (KCNK10) K2P potassium channel can be regulated by variety of polymodal stimuli including pressure. In a recent study, we demonstrated that this mechanosensitive K(+) channel responds to changes in membrane tension by undergoing a major structural change from its 'down' state to the more expanded 'up' state conformation. These changes are mostly restricted to the lower part of the protein within the bilayer, but are allosterically coupled to the primary gating mechanism located within the selectivity filter...
July 19, 2017: Channels
https://www.readbyqxmd.com/read/28723237/linking-chanelopathies-with-endoplasmic-reticulum-associated-degradation
#2
Brighid M O'Donnell, Timothy D Mackie, Jeffrey L Brodsky
No abstract text is available yet for this article.
July 19, 2017: Channels
https://www.readbyqxmd.com/read/28718687/do-sodium-channel-proteolytic-fragments-regulate-sodium-channel-expression
#3
Donatus O Onwuli, Laia Yañez-Bisbe, Mellina Pinsach-Abuin, Anna Tarradas, Ramon Brugada, John Greenman, Sara Pagans, Pedro Beltran-Alvarez
The cardiac voltage-gated sodium channel (gene: SCN5A, protein: NaV1.5) is responsible for the sodium current that initiates the cardiomyocyte action potential. Research into the mechanisms of SCN5A gene expression has gained momentum over the last few years. We have recently described the transcriptional regulation of SCN5A by GATA4 transcription factor. In this addendum to our study, we report our observations that 1) the linker between domains I and II (LDI-DII) of NaV1.5 contains a nuclear localisation signal (residues 474-481) that is necessary to localise LDI-DII into the nucleus, and 2) nuclear LDI-DII activates the SCN5A promoter in gene reporter assays using cardiac-like H9c2 cells...
July 18, 2017: Channels
https://www.readbyqxmd.com/read/28699817/how-may-pi-3-5-p2-impact-on-vacuolar-acidification
#4
Joachim Scholz-Starke
No abstract text is available yet for this article.
July 12, 2017: Channels
https://www.readbyqxmd.com/read/28662361/your-genes-decide-what-you-are-listening-to
#5
Conny Kopp-Scheinpflug
No abstract text is available yet for this article.
June 29, 2017: Channels
https://www.readbyqxmd.com/read/28657512/heat-shock-proteins-and-the-na-h-exchanger
#6
Ayodeji Odunewu-Aderibigbe, Larry Fliegel
No abstract text is available yet for this article.
June 28, 2017: Channels
https://www.readbyqxmd.com/read/28650687/mibefradil-inhibition-of-the-cole-moore-shift-and-k-conductance-of-the-tumor-related-kv10-1-channel
#7
F Gómez-Lagunas, C Barriga-Montoya
No abstract text is available yet for this article.
June 26, 2017: Channels
https://www.readbyqxmd.com/read/28644055/regulation-of-transient-receptor-potential-melastatin-4-channel-by-sarcoplasmic-reticulum-inositol-trisphosphate-receptors-role-in-human-detrusor-smooth-muscle-function
#8
Aaron Provence, Eric S Rovner, Georgi V Petkov
We recently reported key physiologic roles for Ca(2+)-activated transient receptor potential melastatin 4 (TRPM4) channels in detrusor smooth muscle (DSM). However, the Ca(2+)-signaling mechanisms governing TRPM4 channel activity in human DSM cells are unexplored. As the TRPM4 channels are activated by Ca(2+), inositol 1,4,5-trisphosphate receptor (IP3R)-mediated Ca(2+) release from the sarcoplasmic reticulum represents a potential Ca(2+) source for TRPM4 channel activation. We used clinically-characterized human DSM tissues to investigate the molecular and functional interactions of the IP3Rs and TRPM4 channels...
June 23, 2017: Channels
https://www.readbyqxmd.com/read/28636485/mineralocorticoids-modulate-the-expression-of-the-%C3%AE-3-subunit-of-the-na-k-atpase-in-the-renal-collecting-duct
#9
Macarena Rojas, Pablo Díaz, Pablo León, Alexis A Gonzalez, Magdalena González, Víctor Barrientos, Nikolay B Pestov, Rodrigo Alzamora, Luis Michea
Renal sodium reabsorption depends on the activity of the Na(+),K(+)-ATPase α/β heterodimer. Four α (α1-4) and 3 β (β1-3) subunit isoforms have been described. It is accepted that renal tubule cells express α1/β1 dimers. Aldosterone stimulates Na(+),K(+)-ATPase activity and may modulate α1/β1 expression. However, some studies suggest the presence of β3 in the kidney. We hypothesized that the β3 isoform of the Na(+),K(+)-ATPase is expressed in tubular cells of the distal nephron, and modulated by mineralocorticoids...
June 21, 2017: Channels
https://www.readbyqxmd.com/read/28636428/fk506-binding-proteins-12-and-12-6-fkbps-as-regulators-of-cardiac-ryanodine-receptors-insights-from-new-functional-and-structural-knowledge
#10
Luis A Gonano, Peter P Jones
Ryanodine Receptors (RyRs) are intracellular Ca(2+) channels that mediate Ca(2+) flux from the sarco(endo)plasmic reticulum in many cell types. The interaction of RyRs with FK506-binding proteins (FKBPs) has been proposed as an important regulatory mechanism, where the loss of this interaction leads to channel dysfunction. In the heart, phosphorylation of RyR has been suggested to disrupt the RyR-FKBP interaction promoting altered Ca(2+) signaling, heart failure and arrhythmias. However, the functional result of FKBP interaction with RyR and how this interaction is regulated remains highly controversial...
June 21, 2017: Channels
https://www.readbyqxmd.com/read/28633002/the-trpm2-channel-a-thermo-sensitive-metabolic-sensor
#11
Makiko Kashio, Makoto Tominaga
Living organisms continually experience changes in ambient temperature. To detect such temperature changes for adaptive behavioral responses, we evolved the ability to sense temperature. Thermosensitive transient receptor potential (TRP) channels, so-called thermo-TRPs, are involved in many physiologic functions in diverse organisms and constitute important temperature sensors. One of the important roles of thermo-TRPs is detecting ambient temperature in sensory neurons. Importantly, the functional expression of thermo-TRPs is observed not only in sensory neurons but also in tissues and cells that are not exposed to drastic temperature changes, indicating that thermo-TRPs are involved in many physiologic functions within the body's normal temperature range...
June 20, 2017: Channels
https://www.readbyqxmd.com/read/28617626/understanding-the-rules-governing-ncx1-palmitoylation
#12
Fiona Plain, Dionne Turnbull, Niall J Fraser, William Fuller
No abstract text is available yet for this article.
June 15, 2017: Channels
https://www.readbyqxmd.com/read/28598266/reversible-lysine-acetylation-another-layer-of-post-translational-regulation-of-the-cardiac-sodium-channel
#13
Jin-Young Yoon, Ajit Vikram, Barry London, Kaikobad Irani
No abstract text is available yet for this article.
June 9, 2017: Channels
https://www.readbyqxmd.com/read/28569643/the-hook-region-of-%C3%AE-subunits-controls-gating-of-voltage-gated-ca-2-channels-by-electrostatically-interacting-with-plasma-membrane
#14
Cheon-Gyu Park, Byung-Chang Suh
Recently, we showed that the HOOK region of the β2 subunit electrostatically interacts with the plasma membrane and regulates the current inactivation and phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of voltage-gated Ca(2+) (CaV) 2.2 channels. Here, we report that voltage-dependent gating and current density of the CaV2.2 channels are also regulated by the HOOK region of the β2 subunit. The HOOK region can be divided into 3 domains: S (polyserine), A (polyacidic), and B (polybasic). We found that the A domain shifted the voltage-dependent inactivation and activation of CaV2...
June 1, 2017: Channels
https://www.readbyqxmd.com/read/28558254/sensing-the-cold-trp-channels-in-thermal-nociception
#15
Nathaniel J Himmel, Daniel N Cox
No abstract text is available yet for this article.
May 30, 2017: Channels
https://www.readbyqxmd.com/read/28514187/diphenhydramine-inhibits-voltage-gated-proton-channels-hv1-and-induces-acidification-in-leukemic-jurkat-t-cells-new-insights-into-the-pro-apoptotic-effects-of-antihistaminic-drugs
#16
Agustín Asuaje, Pedro Martín, Nicolás Enrique, Leandro Agustín Díaz Zegarra, Paola Smaldini, Guillermo Docena, Verónica Milesi
An established characteristic of neoplastic cells is their metabolic reprogramming, known as the Warburg effect, with greater reliance on energetically less efficient pathways (such as glycolysis and pentose phosphate shunt) compared with oxidative phosphorylation. This results in an overproduction of acidic species that must be extruded to maintain intracellular homeostasis. We recently described that blocking the proton currents in leukemic cells mediated by Hv1 ion channels triggers a marked intracellular acidification and apoptosis induction...
May 17, 2017: Channels
https://www.readbyqxmd.com/read/28498780/ap-and-ca-2-alternans-an-inseparable-couple
#17
Giedrius Kanaporis, Lothar A Blatter
No abstract text is available yet for this article.
May 12, 2017: Channels
https://www.readbyqxmd.com/read/28494190/formate-nitrite-transporters-monoacids-ride-the-dielectric-slide
#18
Marie Wiechert, Eric Beitz
No abstract text is available yet for this article.
May 11, 2017: Channels
https://www.readbyqxmd.com/read/28481659/ion-channel-mechanisms-underlying-frequency-firing-patterns-of-the-avian-nucleus-magnocellularis-a-computational-model
#19
Ting Lu, Kirstie Wade, Hui Hong, Jason Tait Sanchez
We have previously shown that late-developing avian nucleus magnocellularis (NM) neurons (embryonic [E] days 19-21) fire action potentials (APs) that resembles a band-pass filter in response to sinusoidal current injections of varying frequencies. NM neurons located in the mid- to high-frequency regions of the nucleus fire preferentially at 75 Hz, but only fire a single onset AP to frequency inputs greater than 200 Hz. Surprisingly, NM neurons do not fire APs to sinusoidal inputs less than 20 Hz regardless of the strength of the current injection...
May 8, 2017: Channels
https://www.readbyqxmd.com/read/28467171/down-regulation-of-t-type-cav3-2-channels-by-hyperpolarization-activated-cyclic-nucleotide-gated-channel-1-hcn1-evidence-of-a-signaling-complex
#20
Jing Fan, Maria A Gandini, Fang-Xiong Zhang, Lina Chen, Ivana A Souza, Gerald W Zamponi
Formation of complexes between ion channels is important for signal processing in the brain. Here we investigate the biochemical and biophysical interactions between HCN1 channels and Cav3.2 T-type channels. We found that HCN1 co-immunoprecipitated with Cav3.2 from lysates of either mouse brain or tsA-201 cells, with the HCN1 N-terminus associating with the Cav3.2 N-terminus. Cav3.2 channel activity appeared to be functionally regulated by HCN1. The expression of HCN1 induced a decrease in Cav3.2 Ba(2+) influx (IBa(2+)) along with altered channel kinetics and a depolarizing shift in activation gating...
May 3, 2017: Channels
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