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Early Intervention in Psychiatry

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https://www.readbyqxmd.com/read/28880494/clinical-psychopathology-in-youth-at-familial-high-risk-for-psychosis
#1
Jai L Shah, Neeraj Tandon, Debra M Montrose, Diana Mermon, Shaun M Eack, Jean Miewald, Matcheri S Keshavan
AIM: While the course of psychopathology has been explored from an index mental health diagnosis onwards, there are few detailed, prospective studies of the occurrence of clinical psychopathology in youth with familial risk for severe mental illnesses such as psychosis. We sought to describe the appearance of Axis I psychopathology in a unique sample of adolescents with a family history of schizophrenia (FHR). METHODS: One hundred and sixty two first- and second-degree relatives (mean age 15...
September 7, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28858430/social-network-confidants-duration-of-untreated-psychosis-and-cannabis-use-in-people-with-first-episode-psychosis-an-exploratory-study
#2
Giuseppe Carrà, Claudia Battaglia, Mark Hinton, Luke Sheridan Rains, Cristina Crocamo, Sonia Johnson
AIM: Reduced social network (SN) might be associated with a longer duration of untreated psychosis (DUP) in people with first episode psychosis (FEP). We aimed at exploring the specific role of SN confidants on DUP, taking into account cannabis misuse, which is known to influence DUP and might be associated with social functioning. METHODS: People with FEP recently referred to an inner London Early Intervention Service were assessed with standardized instruments exploring SN characteristics, DUP and cannabis misuse...
August 31, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28857488/preliminary-study-of-higher-order-language-and-extralinguistic-impairments-in-individuals-with-high-clinical-risk-of-psychosis-and-first-episode-of-schizophrenia
#3
Agnieszka Pawełczyk, Magdalena Kotlicka-Antczak, Emila Łojek, Tomasz Pawełczyk
AIM: Higher-order language functions are associated with understanding indirect speech acts, lexical-semantic processes, the understanding and production of prosody, discourse production and comprehension. Only a few studies imply that language abnormalities may be present in individuals at ultra-high risk for psychosis (UHR) and first-episode of schizophrenia (FE). The purpose of this study was to test the presence of higher-order language dysfunctions in UHR and FE subjects using a standardized comprehensive test battery...
August 31, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28857431/cost-effectiveness-of-early-intervention-services-for-psychosis-and-fidelity-to-national-policy-implementation-guidance
#4
Muralikrishnan Radhakrishnan, Paul McCrone, Louise Lafortune, Linda Everard, David Fowler, Tim Amos, Nick Freemantle, Swaran P Singh, Max Marshall, Vimal Sharma, Anna Lavis, Peter B Jones, Max Birchwood
AIM: Early intervention services (EIS) for psychosis are being implemented, internationally. It is important to learn from established examples and define the components and intensity of services that provide good value for money. This study aims to assess the cost-effectiveness of EIS according to how closely they adhered to the recommendations of the English Department of Health 2001 Policy Implementation Guide (PIG). METHODS: EIS from the National Eden Study were assessed using a measure of fidelity to the PIG that rated the presence or absence of 64 recommended items relating to team structure and practice...
August 31, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28840977/sensory-characteristics-of-youth-at-clinical-high-risk-for-psychosis
#5
L Diane Parham, Sean Roush, Donna T Downing, Paul G Michael, William R McFarlane
AIM: To identify and compare the sensory characteristics of young people at clinical high risk (CHR) for psychosis to those of peers at clinical low risk (CLR), and to national normative data. CHR and CLR participants were recruited from 6 US regions. METHOD: A descriptive cohort design was used to analyse baseline data collected as part of the Early Detection and Intervention for the Prevention of Psychosis Program (EDIPPP). Raw scores on the Adolescent/Adult Sensory Profile (AASP) were analysed for 205 young people with CHR and 87 with CLR in 2 age groups: 12 to 17 years (N = 203) and 18 to 25 years (N = 89)...
August 25, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28840960/parental-hospital-treated-somatic-illnesses-and-psychosis-of-the-offspring-the-northern-finland-birth-cohort-1986-study
#6
Sami Räsänen, Mika Niemelä, Tanja Nordström, Helinä Hakko, Marianne Haapea, Catherine A Marshall, Jouko Miettunen
AIM: The aim of this study was to investigate whether parental somatic illnesses during childhood increase the risk for later psychosis in the offspring. In addition, we examined which parental illnesses in particular are associated with increased risk of psychosis in the offspring. METHOD: The data of the Northern Finland Birth Cohort 1986 (NFBC 1986), included 9137 children born alive in northern Finland between the July 1, 1985, and the June 30, 1986. Information regarding the parents' somatic morbidity was collected through various healthcare registers up to age 28 of the cohort members...
August 25, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28836377/investigating-service-features-to-sustain-engagement-in-early-intervention-mental-health-services
#7
Mackenzie Becker, Charles E Cunningham, Bruce K Christensen, Ivana Furimsky, Heather Rimas, Fiona Wilson, Lisa Jeffs, Victoria Madsen, Peter Bieling, Yvonne Chen, Stephanie Mielko, Robert B Zipursky
AIM: To understand what service features would sustain patient engagement in early intervention mental health treatment. METHODS: Mental health patients, family members of individuals with mental illness and mental health professionals completed a survey consisting of 18 choice tasks that involved 14 different service attributes. Preferences were ascertained using importance and utility scores. Latent class analysis revealed segments characterized by distinct preferences...
August 23, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28836376/negotiating-the-boundaries-of-psychosis-a-qualitative-study-of-the-service-provider-perspective-on-treatment-delay-in-community-mental-health
#8
Erling Inge Kvig, Cathrine Moe, Beate Brinchmann, Tor Ketil Larsen, Knut Sørgaard
AIM: Evidence shows that many patients are detected and treated late in their course of illness, and that substantial delay occurs even after entry to mental health services. Although several studies have examined the service user and carer perspectives on treatment delay, few have explored the issue from the service provider perspective. The aim of this study was to broaden our understanding of treatment delay by exploring the service provider perspective on reasons for treatment delay in community mental health services...
August 23, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28836352/early-intervention-for-bipolar-disorder-in-adolescents-a-psychosocial-perspective
#9
REVIEW
Claire McAulay, Jonathan Mond, Stephen Touyz
AIM: Early intervention in bipolar disorder (BD) has received increasing attention in recent years. The identification of risk factors has improved, but researchers continue to struggle to find an effective treatment once the illness has become established. The aetiology of BD and feasibility of early intervention present a challenge, making it difficult to decide who to target, as well as how. METHODS: This essay seeks to address the lack of guidance for managing patients with a possible emerging bipolar illness, by presenting a rough roadmap to psychological care...
August 23, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28805304/a-systematic-review-and-meta-analysis-of-mental-health-service-use-in-people-who-report-psychotic-experiences
#10
REVIEW
Vishal Bhavsar, Philip McGuire, James MacCabe, Dominic Oliver, Paolo Fusar-Poli
BACKGROUND: Self-reported psychotic experiences (PEs) are associated with psychopathology of all kinds, not just psychoses. However, systematic reviews on the relevance of this for health services are unavailable. Furthermore, whether association with service use is confounded by other psychopathology is unknown, and is relevant to prevention and treatment. OBJECTIVES: Literature examining associations between PEs and service use was systematically reviewed. Study quality and the direction and extent of any associations were assessed, and meta-analysis conducted...
August 14, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28792130/perceptual-abnormalities-in-an-ultra-high-risk-for-psychosis-population-relationship-to-trauma-and-co-morbid-disorder
#11
Karen O' Connor, Barnaby Nelson, Mary Cannon, Alison Yung, Andrew Thompson
AIMS: The aims of this study were 3-fold. We wished to investigate whether at baseline entry to an ultra-high risk (UHR) clinic whether: (1) perceptual abnormalities are more prevalent in those young people with co-morbid psychiatric diagnoses, (2) perceptual abnormalities are more prevalent in those young people with histories of childhood adversity (childhood trauma, bullying) and (3) perceptual abnormality type is associated with co-morbid psychiatric diagnoses or histories of childhood adversity...
August 9, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28792114/early-psychosis-workforce-development-core-competencies-for-mental-health-professionals-working-in-the-early-psychosis-field
#12
Helen Osman, Anthony F Jorm, Eoin Killackey, Shona Francey, Dianne Mulcahy
AIM: The aim of this study was to identify the core competencies required of mental health professionals working in the early psychosis field, which could function as an evidence-based tool to support the early psychosis workforce and in turn assist early psychosis service implementation and strengthen early psychosis model fidelity. METHOD: The Delphi method was used to establish expert consensus on the core competencies. In the first stage, a systematic literature search was conducted to generate competency items...
August 9, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28792113/the-role-of-a-family-history-of-psychosis-for-youth-at-clinical-high-risk-of-psychosis
#13
Grace Georgopoulos, Jacqueline Stowkowy, Lu Liu, Kristin S Cadenhead, Tyrone D Cannon, Barbara A Cornblatt, Thomas H McGlashan, Diana O Perkins, Larry J Seidman, Ming T Tsuang, Elaine F Walker, Scott W Woods, Carrie E Bearden, Daniel H Mathalon, Jean Addington
AIM: On average, there is a 10% to 12% likelihood of developing a psychotic disorder solely based on being at familial high risk. However, the introduction of the criteria for clinical high risk (CHR) of psychosis suggested for CHR individuals, 20% to 30% will go on to develop a full-blown psychotic illness within 3 years. Several studies suggest a role for family history in conversion to psychosis among those at CHR. However, we know very little about those who meet the CHR criteria and have a positive family history for psychosis compared to those at CHR with no known family history...
August 9, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28786532/blood-cell-count-in-antipsychotic-naive-patients-with-non-affective-psychosis
#14
Clemente Garcia-Rizo, Marta Casanovas, Emilio Fernandez-Egea, Cristina Oliveira, Ana Meseguer, Bibiana Cabrera, Gisela Mezquida, Miquel Bioque, Brian Kirkpatrick, Miquel Bernardo
BACKGROUND: Schizophrenia is a complex medical entity with a reduced life expectancy, mostly due to an increased prevalence of cardiovascular diseases compared to the general population. An unbalanced immune response and a pro-inflammatory state might underlie this process. In treated patients, abnormal white blood cell (WBC), lymphocyte and neutrophil count suggests atypical immune response related to clinical variables. We aimed to test the hypothesis that newly diagnosed naïve patients with non-affective psychosis would show abnormal blood cell count values after controlling for potential confounding factors compared to matched controls...
August 8, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28786526/suicidal-ideation-and-burnout-among-psychiatric-trainees-in-japan
#15
Masaru Tateno, Nikolina Jovanović, Julian Beezhold, Kumi Uehara-Aoyama, Wakako Umene-Nakano, Takashi Nakamae, Naoki Uchida, Naoki Hashimoto, Saya Kikuchi, Yosuke Wake, Daisuke Fujisawa, Keisuke Ikari, Kotaro Otsuka, Katsuyoshi Takahashi, Gaku Okugawa, Norio Watanabe, Tomohiro Shirasaka, Takahiro A Kato
AIM: Burnout is a psychological condition that may occur in all workers after being exposed to excessive work-related stresses. We investigated suicidal ideation and burnout among Japanese psychiatric trainees as a part of the Burnout Syndrome Study (BoSS) International. METHODS: In the Japanese branch, 91 trainees fully completed suicide ideation and behaviour questionnaire (SIBQ) and Maslach Burnout Inventory-General Survey (MBI-GS). RESULTS: Passive suicidal ideation was reported by 38...
August 8, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28782283/psychosis-risk-screening-in-different-populations-using-the-prodromal-questionnaire-a-systematic-review
#16
REVIEW
Mark Savill, Jennifer D'Ambrosio, Tyrone D Cannon, Rachel L Loewy
AIM: Diagnosing individuals at ultra high risk (UHR) for psychosis can improve early access to treatment, and a two-stage model utilizing self-report screening followed by a clinical interview can be accurate and efficient. However, it is currently unclear which screening cut-offs to adopt with different populations. METHODS: A systematic review of diagnostic accuracy studies evaluating the Prodromal Questionnaire (PQ) as a preliminary screener for UHR and psychosis was conducted to examine screening effectiveness in different contexts...
August 6, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28776930/early-intervention-for-youth-at-high-risk-for-bipolar-disorder-a-multisite-randomized-trial-of-family-focused-treatment
#17
David J Miklowitz, Christopher D Schneck, Patricia D Walshaw, Amy S Garrett, Manpreet K Singh, Catherine A Sugar, Kiki D Chang
AIMS: Despite the considerable public health impact of bipolar disorder (BD), no psychosocial interventions have been systematically evaluated in its early prodromal stages. We describe the rationale, design and analytic methods for a 3-site randomized trial of family-focused treatment for youth at high risk (FFT-HR) for BD. METHODS: Participants (ages 9-17 years) have a diagnosis of unspecified BD or major depressive disorder, current mood symptoms and at least one first- or second-degree relative with a lifetime history of BD I or II...
August 4, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28776924/updated-meta-analysis-of-cmya5-rs3828611-and-rs4704591-with-schizophrenia-in-asian-populations
#18
Satoshi Hoya, Yuichiro Watanabe, Masako Shibuya, Toshiyuki Someya
AIM: Two single-nucleotide polymorphisms, rs3828611 and rs4704591, in the cardiomyopathy-associated protein 5 (CMYA5) gene have been extensively investigated for associations with schizophrenia in Asian populations, but with conflicting results. To assess the collective evidence across individual studies, we conducted an updated meta-analysis. METHODS: We performed a random-effect model meta-analysis of the associations of rs3828611 and rs4704591 with schizophrenia using seven case-control samples from Asian populations (8074 patients and 8139 controls)...
August 4, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28776920/creating-an-innovative-youth-mental-health-service-in-the-united-kingdom-the-norfolk-youth-service
#19
Jon Wilson, Tim Clarke, Rebecca Lower, Uju Ugochukwu, Sarah Maxwell, Jo Hodgekins, Karen Wheeler, Andy Goff, Robert Mack, Rebecca Horne, David Fowler
Young people attempting to access mental health services in the United Kingdom often find traditional models of care outdated, rigid, inaccessible and unappealing. Policy recommendations, research and service user opinion suggest that reform is needed to reflect the changing needs of young people. There is significant motivation in the United Kingdom to transform mental health services for young people, and this paper aims to describe the rationale, development and implementation of a novel youth mental health service in the United Kingdom, the Norfolk Youth Service...
August 4, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28771938/changes-in-symptom-content-from-a-clinical-high-risk-state-to-conversion-to-psychosis
#20
Catherine Marshall, Yun Lu, Kristina Lyngberg, Stephanie Deighton, Kristin S Cadenhead, Tyrone D Cannon, Barbara A Cornblatt, Thomas H McGlashan, Diana O Perkins, Larry J Seidman, Ming T Tsuang, Elaine F Walker, Scott W Woods, Carrie E Bearden, Daniel Mathalon, Jean Addington
AIM: There is an interest in the transition to psychosis for those at clinical high risk of developing psychosis. This transition is typically determined by a change in severity of the attenuated symptoms as they reach a psychotic level. However, any concomitant change in the content of such symptoms has not been examined. The current study aimed to examine potential qualitative changes in the symptom content from a clinical high-risk state to a first episode of psychosis. METHODS: Sixty-seven individuals, who had been identified as meeting the attenuated psychotic syndrome based on the Structured Interview of Psychosis-Risk Syndromes and who later developed a full-blown psychosis were included in the study...
August 3, 2017: Early Intervention in Psychiatry
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