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Early Intervention in Psychiatry

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https://www.readbyqxmd.com/read/28805304/a-systematic-review-and-meta-analysis-of-mental-health-service-use-in-people-who-report-psychotic-experiences
#1
REVIEW
Vishal Bhavsar, Philip McGuire, James MacCabe, Dominic Oliver, Paolo Fusar-Poli
BACKGROUND: Self-reported psychotic experiences (PEs) are associated with psychopathology of all kinds, not just psychoses. However, systematic reviews on the relevance of this for health services are unavailable. Furthermore, whether association with service use is confounded by other psychopathology is unknown, and is relevant to prevention and treatment. OBJECTIVES: Literature examining associations between PEs and service use was systematically reviewed. Study quality and the direction and extent of any associations were assessed, and meta-analysis conducted...
August 14, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28792130/perceptual-abnormalities-in-an-ultra-high-risk-for-psychosis-population-relationship-to-trauma-and-co-morbid-disorder
#2
Karen O' Connor, Barnaby Nelson, Mary Cannon, Alison Yung, Andrew Thompson
AIMS: The aims of this study were 3-fold. We wished to investigate whether at baseline entry to an ultra-high risk (UHR) clinic whether: (1) perceptual abnormalities are more prevalent in those young people with co-morbid psychiatric diagnoses, (2) perceptual abnormalities are more prevalent in those young people with histories of childhood adversity (childhood trauma, bullying) and (3) perceptual abnormality type is associated with co-morbid psychiatric diagnoses or histories of childhood adversity...
August 9, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28792114/early-psychosis-workforce-development-core-competencies-for-mental-health-professionals-working-in-the-early-psychosis-field
#3
Helen Osman, Anthony F Jorm, Eoin Killackey, Shona Francey, Dianne Mulcahy
AIM: The aim of this study was to identify the core competencies required of mental health professionals working in the early psychosis field, which could function as an evidence-based tool to support the early psychosis workforce and in turn assist early psychosis service implementation and strengthen early psychosis model fidelity. METHOD: The Delphi method was used to establish expert consensus on the core competencies. In the first stage, a systematic literature search was conducted to generate competency items...
August 9, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28792113/the-role-of-a-family-history-of-psychosis-for-youth-at-clinical-high-risk-of-psychosis
#4
Grace Georgopoulos, Jacqueline Stowkowy, Lu Liu, Kristin S Cadenhead, Tyrone D Cannon, Barbara A Cornblatt, Thomas H McGlashan, Diana O Perkins, Larry J Seidman, Ming T Tsuang, Elaine F Walker, Scott W Woods, Carrie E Bearden, Daniel H Mathalon, Jean Addington
AIM: On average, there is a 10% to 12% likelihood of developing a psychotic disorder solely based on being at familial high risk. However, the introduction of the criteria for clinical high risk (CHR) of psychosis suggested for CHR individuals, 20% to 30% will go on to develop a full-blown psychotic illness within 3 years. Several studies suggest a role for family history in conversion to psychosis among those at CHR. However, we know very little about those who meet the CHR criteria and have a positive family history for psychosis compared to those at CHR with no known family history...
August 9, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28786532/blood-cell-count-in-antipsychotic-naive-patients-with-non-affective-psychosis
#5
Clemente Garcia-Rizo, Marta Casanovas, Emilio Fernandez-Egea, Cristina Oliveira, Ana Meseguer, Bibiana Cabrera, Gisela Mezquida, Miquel Bioque, Brian Kirkpatrick, Miquel Bernardo
BACKGROUND: Schizophrenia is a complex medical entity with a reduced life expectancy, mostly due to an increased prevalence of cardiovascular diseases compared to the general population. An unbalanced immune response and a pro-inflammatory state might underlie this process. In treated patients, abnormal white blood cell (WBC), lymphocyte and neutrophil count suggests atypical immune response related to clinical variables. We aimed to test the hypothesis that newly diagnosed naïve patients with non-affective psychosis would show abnormal blood cell count values after controlling for potential confounding factors compared to matched controls...
August 8, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28786526/suicidal-ideation-and-burnout-among-psychiatric-trainees-in-japan
#6
Masaru Tateno, Nikolina Jovanović, Julian Beezhold, Kumi Uehara-Aoyama, Wakako Umene-Nakano, Takashi Nakamae, Naoki Uchida, Naoki Hashimoto, Saya Kikuchi, Yosuke Wake, Daisuke Fujisawa, Keisuke Ikari, Kotaro Otsuka, Katsuyoshi Takahashi, Gaku Okugawa, Norio Watanabe, Tomohiro Shirasaka, Takahiro A Kato
AIM: Burnout is a psychological condition that may occur in all workers after being exposed to excessive work-related stresses. We investigated suicidal ideation and burnout among Japanese psychiatric trainees as a part of the Burnout Syndrome Study (BoSS) International. METHODS: In the Japanese branch, 91 trainees fully completed suicide ideation and behaviour questionnaire (SIBQ) and Maslach Burnout Inventory-General Survey (MBI-GS). RESULTS: Passive suicidal ideation was reported by 38...
August 8, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28782283/psychosis-risk-screening-in-different-populations-using-the-prodromal-questionnaire-a-systematic-review
#7
REVIEW
Mark Savill, Jennifer D'Ambrosio, Tyrone D Cannon, Rachel L Loewy
AIM: Diagnosing individuals at ultra high risk (UHR) for psychosis can improve early access to treatment, and a two-stage model utilizing self-report screening followed by a clinical interview can be accurate and efficient. However, it is currently unclear which screening cut-offs to adopt with different populations. METHODS: A systematic review of diagnostic accuracy studies evaluating the Prodromal Questionnaire (PQ) as a preliminary screener for UHR and psychosis was conducted to examine screening effectiveness in different contexts...
August 6, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28776930/early-intervention-for-youth-at-high-risk-for-bipolar-disorder-a-multisite-randomized-trial-of-family-focused-treatment
#8
David J Miklowitz, Christopher D Schneck, Patricia D Walshaw, Amy S Garrett, Manpreet K Singh, Catherine A Sugar, Kiki D Chang
AIMS: Despite the considerable public health impact of bipolar disorder (BD), no psychosocial interventions have been systematically evaluated in its early prodromal stages. We describe the rationale, design and analytic methods for a 3-site randomized trial of family-focused treatment for youth at high risk (FFT-HR) for BD. METHODS: Participants (ages 9-17 years) have a diagnosis of unspecified BD or major depressive disorder, current mood symptoms and at least one first- or second-degree relative with a lifetime history of BD I or II...
August 4, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28776924/updated-meta-analysis-of-cmya5-rs3828611-and-rs4704591-with-schizophrenia-in-asian-populations
#9
Satoshi Hoya, Yuichiro Watanabe, Masako Shibuya, Toshiyuki Someya
AIM: Two single-nucleotide polymorphisms, rs3828611 and rs4704591, in the cardiomyopathy-associated protein 5 (CMYA5) gene have been extensively investigated for associations with schizophrenia in Asian populations, but with conflicting results. To assess the collective evidence across individual studies, we conducted an updated meta-analysis. METHODS: We performed a random-effect model meta-analysis of the associations of rs3828611 and rs4704591 with schizophrenia using seven case-control samples from Asian populations (8074 patients and 8139 controls)...
August 4, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28776920/creating-an-innovative-youth-mental-health-service-in-the-united-kingdom-the-norfolk-youth-service
#10
Jon Wilson, Tim Clarke, Rebecca Lower, Uju Ugochukwu, Sarah Maxwell, Jo Hodgekins, Karen Wheeler, Andy Goff, Robert Mack, Rebecca Horne, David Fowler
Young people attempting to access mental health services in the United Kingdom often find traditional models of care outdated, rigid, inaccessible and unappealing. Policy recommendations, research and service user opinion suggest that reform is needed to reflect the changing needs of young people. There is significant motivation in the United Kingdom to transform mental health services for young people, and this paper aims to describe the rationale, development and implementation of a novel youth mental health service in the United Kingdom, the Norfolk Youth Service...
August 4, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28771938/changes-in-symptom-content-from-a-clinical-high-risk-state-to-conversion-to-psychosis
#11
Catherine Marshall, Yun Lu, Kristina Lyngberg, Stephanie Deighton, Kristin S Cadenhead, Tyrone D Cannon, Barbara A Cornblatt, Thomas H McGlashan, Diana O Perkins, Larry J Seidman, Ming T Tsuang, Elaine F Walker, Scott W Woods, Carrie E Bearden, Daniel Mathalon, Jean Addington
AIM: There is an interest in the transition to psychosis for those at clinical high risk of developing psychosis. This transition is typically determined by a change in severity of the attenuated symptoms as they reach a psychotic level. However, any concomitant change in the content of such symptoms has not been examined. The current study aimed to examine potential qualitative changes in the symptom content from a clinical high-risk state to a first episode of psychosis. METHODS: Sixty-seven individuals, who had been identified as meeting the attenuated psychotic syndrome based on the Structured Interview of Psychosis-Risk Syndromes and who later developed a full-blown psychosis were included in the study...
August 3, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28758344/characterizing-the-inpatient-care-of-young-adults-experiencing-early-psychosis-a-medical-record-review
#12
Joseph H Puyat, Renata Kamieniecki, Brenda Vaughan, Tamara Mihic, Kofi Bonnie, Jeffrey Danielson, Sierra Williams
AIM: To characterize the inpatient care received by individuals experiencing early psychotic episodes in an inner city hospital. METHOD: Medical records of patients admitted between April 01, 2013, and March 31, 2015, to a psychiatric ward at an inner city hospital were retrospectively examined. Included in the study are patients who were 25 years of age or younger and were hospitalized for psychotic symptoms. Demographics and health service use were summarized using descriptive statistics...
July 31, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28745012/validation-of-the-early-detection-primary-care-checklist-in-an-italian-community-help-seeking-sample-the-checklist-per-la-valutazione-dell-esordio-psicotico
#13
Lorenzo Pelizza, Andrea Raballo, Enrico Semrov, Luigi Rocco Chiri, Silvia Azzali, Ilaria Scazza, Sara Garlassi, Federica Paterlini, Francesca Fontana, Rosanna Favazzo, Luana Pensieri, Michela Fabiani, Leonardo Cioncolini, Simona Pupo
BACKGROUND: To establish the concordant validity of the "Checklist per la Valutazione dell'Esordio Psicotico" (CVEP) in an Italian help-seeking population. The CVEP is the Italian adaptation of the "early detection Primary Care Checklist," a 20-item tool specifically designed to assist primary care practitioners in identifying young people in the early stages of psychosis. METHODS: The checklist was completed by the referring practitioners of 168 young people referred to the "Reggio Emilia At Risk Mental States" Project, an early detection infrastructure developed under the aegis of the Regional Project on Early Detection of Psychosis in the Reggio Emilia Department of Mental Health...
July 26, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28745011/enhancing-prevention-and-intervention-for-youth-concurrent-mental-health-and-substance-use-disorders-the-research-and-action-for-teens-study
#14
Joanna L Henderson, E B Brownlie, Shelley McMain, Gloria Chaim, David A Wolfe, Brian Rush, Tali Boritz, Joseph H Beitchman
BACKGROUND: Concurrent mental health and substance use disorders among youth are associated with functional impairment in developmentally salient domains, yet research on prevention and intervention for this vulnerable population is sparse. This paper describes the rationale and design of the Research and Action for Teens study, an initiative designed to strengthen the evidence base for prevention, screening, treatment and service delivery for youth concurrent mental health and substance use concerns...
July 26, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28744989/impact-of-rurality-and-substance-use-on-young-people-at-ultra-high-risk-for-psychosis
#15
Helen J Stain, Sean A Halpin, Amanda L Baker, Mike Startup, Vaughan J Carr, Ulrich Schall, Kylie Crittenden, Vanessa Clark, Terry J Lewin, Sandra Bucci
BACKGROUND: Longitudinal research into early intervention for youth at ultra high risk (UHR) for psychosis demonstrates beneficial outcomes including increased treatment compliance and greater participation in education and the workforce. Despite known barriers for rural youth accessing mental health services, research comparing urban and rural UHR youth is lacking. The study included an examination of the impact of substance use on functioning of UHR youth. METHODS: Youth aged 12 to 25 years were recruited from the urban area of Newcastle or the rural area of Orange, New South Wales, Australia, and identified as UHR by the Comprehensive Assessment of At Risk Mental States...
July 26, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28744970/evaluation-of-a-professional-development-training-programme-for-mental-health-clinicians-specializing-in-early-psychosis
#16
Craig Macneil, Frances Foster, Amanda Nicoll, Helen Osman, Richard Monfries, Sue Cotton
The Early Psychosis Prevention and Intervention Centre Statewide Services (ESW) team provides training for multidisciplinary clinicians that specialise in early psychosis across the State of Victoria, Australia. The aim of this paper is to describe the 4-phase approach utilised by ESW to prepare for and deliver workshops, to report on participants' ratings of the ESW workshops, and to make recommendations for other trainers of early psychosis clinicians. Between March 2009 and September 2014, ESW provided 85 training workshops that had a strong focus on evidence-based approaches and international guidelines, and utilized clinical examples of early psychosis interventions...
July 26, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28719155/antipsychotic-treatment-is-associated-with-inflammatory-and-metabolic-biomarkers-alterations-among-first-episode-psychosis-patients-a-7-month-follow-up-study
#17
Roman Balõtšev, Liina Haring, Kati Koido, Vambola Leping, Kärt Kriisa, Mihkel Zilmer, Veiko Vasar, Anneli Piir, Aavo Lang, Eero Vasar
AIM: Second-generation antipsychotics are commonly used to treat schizophrenia, but may cause metabolic syndrome (MetS) in a subset of patients. The mechanisms of antipsychotic-related metabolic changes remain to be established, especially in first-episode psychosis (FEP) patients. METHODS: In the present study, we used a chip technology to measure metabolic (C-peptide, insulin, leptin, adiponectin and resistin) and inflammatory biomarkers (ferritin, interleukin-6, interleukin-1α, tumour necrosis factor-α and plasminogen activator inhibitor-1) in the serum samples of a population of FEP patients before and after 7 months of antipsychotic drug treatment, compared to control subjects (CS)...
July 18, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28719151/staged-treatment-in-early-psychosis-a-sequential-multiple-assignment-randomised-trial-of-interventions-for-ultra-high-risk-of-psychosis-patients
#18
REVIEW
Barnaby Nelson, G Paul Amminger, Hok Pan Yuen, Nicky Wallis, Melissa J Kerr, Lisa Dixon, Cameron Carter, Rachel Loewy, Tara A Niendam, Martha Shumway, Sarah Morris, Julie Blasioli, Patrick D McGorry
AIM: Previous research indicates that preventive intervention is likely to benefit patients "at risk" of psychosis, in terms of functional improvement, symptom reduction and delay or prevention of onset of threshold psychotic disorder. The primary aim of the current study is to test outcomes of ultra high risk (UHR) patients, primarily functional outcome, in response to a sequential intervention strategy consisting of support and problem solving (SPS), cognitive-behavioural case management and antidepressant medication...
July 18, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28719056/tracking-salience-in-young-people-a-psychometric-field-test-of-the-aberrant-salience-inventory-asi
#19
Andrea Raballo, David C Cicero, John G Kerns, Sara Sanna, Mirra Pintus, Ingrid Agartz, Elisa Pintus, Irene Corrias, Veronica Lai, Donatella Rita Petretto, Mauro G Carta, Antonio Preti
AIM: To explore the prevalence of Aberrant Salience (AS, an alleged experiential feature of psychosis-proneness) in Italian young people and corroborate the transcultural validity of the Aberrant Salience Inventory (ASI). METHODS: Young adults attending an Italian university (n = 649) underwent serial evaluations with the ASI together with psychometric proxies for help seeking General Health Questionnaire and attenuated positive and negative symptoms Schizotypal Personality Questionnaire (SPQ)...
July 18, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28718985/relationships-between-the-frequency-and-severity-of-non-suicidal-self-injury-and-suicide-attempts-in-youth-with-borderline-personality-disorder
#20
Holly E Andrewes, Carol Hulbert, Susan M Cotton, Jennifer Betts, Andrew M Chanen
AIM: Non-suicidal self-injury (NSSI) is a recognized indicator of suicide risk. Yet, the ubiquity of this behaviour in borderline personality disorder (BPD) limits its utility as a predictor of risk. Consequently, this study aimed to elucidate the relationship between other features of NSSI, including frequency and severity, and suicide attempts. METHOD: Participants included 107 youth (15 to 25 year olds) with BPD who were assessed for BPD severity, depressive symptoms, 12-month frequency of NSSI and suicide attempts, as well as the levels of treatment sought following each self-harm event...
July 18, 2017: Early Intervention in Psychiatry
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