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Early Intervention in Psychiatry

Suzanne Di Capite, Rachel Upthegrove, Pavan Mallikarjun
BACKGROUND: To determine the "real world" relapse rate in patients with first-episode psychosis (FEP) who had discontinued antipsychotic medication and identify socio-demographic and clinical factors associated with the risk of relapse. METHODS: Quantitative data were obtained via case-note review on 63 patients with FEP who had discontinued antipsychotic medication from Birmingham Early Intervention Service between 2012 and 2015. The follow-up period was until either: an occurrence of a relapse; end of 12-month study period; end of patient's case-note record...
October 13, 2016: Early Intervention in Psychiatry
Catherine Shiu-Yin Chong, Man-Wah Siu, Condy Hoi-Shuen Kwan, Wing-Chung Chang, Edwin Ho-Ming Lee, Sherry Kit-Wa Chan, Christy Lai-Ming Hui, Fiona Yee-Ki Tam, Eric Yu-Hai Chen, William Tak-Lam Lo
AIM: To explore the changes of functioning in people suffering from first-episode psychosis throughout their first year into an early intervention service, and the baseline predictors of their functioning levels at baseline, 6 and 12 months METHOD: Consecutive subjects presenting to an early intervention service were recruited from 1 February 2013 to 31 May 2015. Information on their socio-demographic status was collected. Structured instruments were used to assess their premorbid functioning, duration of untreated psychosis, psychopathology and insight at baseline...
October 12, 2016: Early Intervention in Psychiatry
Robin E Gearing, Kathryne B Brewer, Irfan Mian, Kiara Moore, Prudence Fisher, Jane Hamilton, James Mandiberg
AIM: The timely identification and treatment of psychosis are increasingly the focus of early interventions, with research targeting the initial high-risk period in the months following first-episode hospitalization. Ongoing treatment after stabilization is also essential in the years following a first-episode psychosis (FEP), but has received less research attention. In this study, variables that could impact continued psychiatric service utilization by adolescents following their FEP and temporal patterns in service utilization are examined...
October 11, 2016: Early Intervention in Psychiatry
Simon Rice, Stephen Halperin, Simon Blaikie, Katherine Monson, Rachel Stefaniak, Mark Phelan, Christopher Davey
AIM: Although models of family intervention are clearly articulated in the child and early adolescent literature, there is less clarity regarding family intervention approaches in later adolescence and emerging adulthood. METHODS: This study provides the rationale and intervention framework for a developmentally sensitive model of time-limited family work in the outpatient treatment of complex youth depression (15-25 years). RESULTS: Derived from current practice in the Youth Mood Clinic (YMC) at Orygen Youth Health, Melbourne, a stepped model of family intervention is discussed...
October 2, 2016: Early Intervention in Psychiatry
Anders L Dannevang, Lasse Randers, Matthias Gondan, Kristine Krakauer, Dorte Nordholm, Merete Nordentoft
AIM: Deterioration in premorbid adjustment is related to ultra-high risk (UHR) individuals developing psychosis, but it has not been examined how UHR individuals' development differs compared to healthy controls. This study investigates differences in premorbid adjustment between UHR individuals and a healthy control group. METHOD: A total of 48 UHR individuals and 50 healthy controls matched on group level for age, gender and parents' socio-economic status were included in the study...
September 29, 2016: Early Intervention in Psychiatry
Alice Oppetit, Julie Bourgin, Gilles Martinez, Mathilde Kazes, Célia Mam-Lam-Fook, Raphael Gaillard, Jean-Pierre Olié, Marie-Odile Krebs
AIM: The aim is to describe a centre operating in Paris that pioneers the early intervention for young people at the onset and at high risk of psychosis in France. METHODS: Comprehensive descriptive analysis of different clinical and service measures is used in describing the implementation of the C'JAAD (Evaluation Centre for Young Adults and Adolescents) using data from an ongoing prospective non-interventional research programme. RESULTS: Over a 2-year period, 151 patients were referred to the C'JAAD and included in the ICAAR research programme...
September 28, 2016: Early Intervention in Psychiatry
Marleine Azar, Marita Pruessner, Lawrence H Baer, Srividya Iyer, Ashok K Malla, Martin Lepage
BACKGROUND: Negative symptoms are known to be present in the prodromal stage of psychotic disorders, yet little is known about their prevalence. Studies examining the presence of negative symptoms in ultra-high risk (UHR) populations have shown some limitations, notably failing to control depression. The objective of this study was to examine the prevalence of negative symptoms in the presence of significant levels of depression and in the absence of such symptoms (primary negative symptoms) over 1 year and to examine differences in negative symptoms in psychosis converters and non-converters...
September 21, 2016: Early Intervention in Psychiatry
Giulia Gattere, Alexander Stojanovic-Pérez, Rosa Monseny, Lourdes Martorell, Laura Ortega, Itziar Montalvo, Montse Solé, María José Algora, Ángel Cabezas, Rebecca M Reynolds, Elisabet Vilella, Javier Labad
AIM: The brain-derived neurotrophic factor (BDNF) is a major participant in the regulation of food intake and may play a role in the regulation of the stress response. We aimed to investigate whether there is a gene-environment interaction in the relationship between stress and BDNF Val66Met polymorphism in relation to dietary patterns in a sample of subjects with early psychosis. METHODS: We studied 124 early psychotic disorder (PD) patients, 36 At-Risk Mental States (ARMS) and 62 healthy subjects (HS)...
September 15, 2016: Early Intervention in Psychiatry
Margaret A Mariano, Kerri Tang, Matthew Kurtz, Wendy R Kates
AIM: Schizophrenia and 22q11.2 deletion syndrome (22q11DS) share similar patterns of cognitive deficits. Up to 30% of those with 22q11DS develop schizophrenia during early adulthood. As cognitive decline has recently been found to predict onset of psychosis in adolescents with 22q11DS, early interventions such as cognitive remediation (CR) during adolescence are warranted. This paper investigates the durability of a remote, computerized, CR programme for youth with 22q11DS. Our aim was to determine if the positive effects of CR persisted 6 months beyond intervention completion...
September 15, 2016: Early Intervention in Psychiatry
Tom A Hummer, Michael M Francis, Jenifer L Vohs, Emily Liffick, Nicole F Mehdiyoun, Alan Breier
AIM: White matter abnormalities have been reported in schizophrenia and may indicate altered cortical network integrity and structural connectivity, which have been hypothesized as key pathophysiological components of this illness. In this study, we aimed to further characterize the nature and progression of white matter alterations during the early stages of the disorder. METHODS: We employed diffusion tensor imaging (DTI) approaches to investigate fractional anisotropy (FA), radial diffusivity (RD) and axial diffusivity (AD) in 40 patients with schizophrenia and related psychotic disorders (aged 18-30 years) who were within 5 years of illness, along with an age-, sex- and race-matched sample of 21 healthy controls...
September 13, 2016: Early Intervention in Psychiatry
Amy Brown, Jessica McClelland, Elena Boysen, Victoria Mountford, Danielle Glennon, Ulrike Schmidt
AIM: Eating disorders (EDs) are disabling disorders, predominantly affecting adolescents and young adults. Untreated symptoms have lasting effects on brain, body and behaviour. Care pathway-related barriers often prevent early detection and treatment of ED. The aim of this study was to assess the feasibility and acceptability of FREED (First Episode and Rapid Early Intervention for Eating Disorder), a novel service for young people (aged 18-25 years) with recent ED onset (≤3 years), embedded in a specialist adult National Health Service ED service...
September 13, 2016: Early Intervention in Psychiatry
Emmi Keskinen, Riikka Marttila, Heli Koivumaa-Honkanen, Kristiina Moilanen, Sirkka Keinänen-Kiukaanniemi, Markku Timonen, Matti Isohanni, John McGrath, Jouko Miettunen, Erika Jääskeläinen
AIM: To find factors that are associated with not having psychotic illness in a prospective general population sample, with a special interest in individuals with parental psychosis. METHODS: Data from the Northern Finland Birth Cohort 1966 (n = 10 458) and several registers were used to detect individuals with and without parental psychosis. Altogether, 594 persons had parent(s) with psychosis and 48 of them also had psychosis subsequently. Variables related to pregnancy and birth, family and childhood, health and habits in adolescence, school performance and physical activity were studied to identify determinants of unaffected status among individuals with and without parental psychosis...
September 13, 2016: Early Intervention in Psychiatry
Martin Lambert, Daniel Schöttle, Mary Sengutta, Friederike Ruppelt, Anja Rohenkohl, Daniel Luedecke, Luise Antonia Nawara, Britta Galling, Anne-Lena Falk, Linus Wittmann, Vivien Niehaus, Gizem Sarikaya, Ute Handwerk, Wiebke Rothländer, Liz Rietschel, Charlotte Gagern, Benjamin Lange, Christina Meigel-Schleiff, Dieter Naber, Michael Schulte-Markwort, Helmut Krüger, Hans-Peter Unger, Sven Sippel, Sabine Ott, Georg Romer, Anne Daubmann, Karl Wegscheider, Christoph U Correll, Benno G Schimmelmann, Thomas Bock, Jürgen Gallinat, Anne Karow
AIM: The Integrated Care in Early Psychosis (ACCESS III) Study examined the efficacy and cost-effectiveness of a combined intervention consisting of strategies to improve early detection and quality of care (integrated care including therapeutic assertive community treatment) in adolescents and young adults in the early phase of a severe psychotic disorder from 2011 to 2014. METHODS: This is a prospective, single-centre, 1-year cohort study comparing an intervention condition (early detection plus integrated care, n = 120) to the historical control condition (standard care, SC, n = 105) for adolescents and young adults aged 12-29 years suffering from a severe, early-phase psychotic disorder (i...
September 12, 2016: Early Intervention in Psychiatry
Maya Gupta, Christopher R Bowie
AIM: Research suggests that family support promotes recovery and is a key component of a successful early intervention programme. However, very little is known about family functioning in families that are coping with the onset of a psychotic illness and the factors that help to foster adaptive family functioning during this challenging time. The purpose of this study was to understand the individual, caregiver and family factors that are associated with adaptive family functioning in early episode psychosis...
September 7, 2016: Early Intervention in Psychiatry
Brioney Gee, Caitlin Notley, Rory Byrne, Tim Clarke, Jo Hodgekins, Paul French, David Fowler
AIM: The PRODIGY trial is an ongoing randomized controlled trial of Social Recovery Cognitive Behavioural Therapy (SRCBT), a new intervention designed to improve social functioning in young people at risk of long-term social disability due to severe and complex mental health problems. The aim of this qualitative sub-study was to understand trial participants' experiences of SRCBT and the control condition, treatment as usual. METHODS: Trial participants were aged 16-25 years with socially disabling severe and complex mental health problems...
September 7, 2016: Early Intervention in Psychiatry
Kyung-Ok Lim, Tae Young Lee, Minah Kim, Myong-Wuk Chon, Je-Yeon Yun, Sung Nyun Kim, Jun Soo Kwon
AIM: A clinical high risk (CHR) for psychosis is regarded as the state of being at risk of developing psychosis. However, the rate of transition to psychosis among CHR subjects has been declining over time. We aimed to investigate the effects of the possible causes of the declining transition rate. METHODS: A total of 129 CHR subjects were divided into two groups according to the date of enrollment: the 2005-2009 group and the 2009-2013 group. Baseline demographic and clinical characteristics, including medication prescription, were compared...
September 7, 2016: Early Intervention in Psychiatry
Davy Vancampfort, Marc De Hert, Julie Broderick, Oscar Lederman, Joseph Firth, Simon Rosenbaum, Michel Probst
AIM: Physical activity has the potential to improve the health of patients with first-episode psychosis (FEP), yet many patients with FEP remain inactive. Exploring the theoretical basis of the motivational processes linked to the adoption and maintenance of physical activity behaviours in FEP patients can assist with the design and delivery of physical activity interventions. Within the self-determination theory and the transtheoretical model (stages of change) frameworks, we investigated motives for physical activity adoption and maintenance in FEP...
September 4, 2016: Early Intervention in Psychiatry
Kellie L Hadden, Kellie LeDrew, Kevin Hogan, Barbara Thomas
AIM: Comorbid cannabis abuse is common in patients with early psychosis. Little is known about the effect of stopping cannabis use on positive, negative and depressive symptoms. Few studies have controlled for multiple substance use that may mask the specific role that cannabis plays in symptom outcomes. The aim of this study was to investigate whether course and level of cannabis use negatively impacted early psychosis patient symptom profiles (positive, negative and depressive symptoms) over 24 months...
September 4, 2016: Early Intervention in Psychiatry
Joseph Firth, Rebekah Carney, Paul French, Rebecca Elliott, Jack Cotter, Alison R Yung
AIM: The aims of this study were to examine if people with first-episode psychosis (FEP) are able to continue adhering to exercise after a supervised intervention and to explore if the benefits of exercise can be sustained. METHODS: Twenty-eight persons with FEP took part in a 10-week exercise intervention that provided each participant with twice-weekly accompaniment to exercise activities of their own choice, of whom 20 were re-assessed 6 months after the intervention...
September 1, 2016: Early Intervention in Psychiatry
Cheng-Che Shen, Li-Yu Hu, Shih-Jen Tsai, Albert C Yang, Pan-Ming Chen, Ya-Han Hu
AIM: To develop a risk stratification model for the early diagnosis of borderline personality disorder (BPD) using Taiwan National Health Insurance Research Database. METHODS: We conducted a retrospective case-control study of 6132 patients (292 BPD patients and 5840 control subjects) who were selected from the National Health Insurance Research Database. Psychiatric co-morbidities including depressive disorder, bipolar disorder, anxiety disorder, substance-use disorder, personality disorders other than BPD, sleep disorder, eating disorder, autistic spectrum disorder, mental retardation and attention-deficit hyperactivity disorder, which were diagnosed within 3 years before enrolment, were collected...
September 1, 2016: Early Intervention in Psychiatry
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