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Early Intervention in Psychiatry

Kristen Thien, Brian O'Donoghue
AIM: While the majority of individuals with a first episode of psychosis (FEP) achieve symptomatic remission with the appropriate treatment, there is a small but significant proportion who do not achieve remission of symptoms despite adequate treatment with at least two antipsychotic medications (termed treatment resistance). Clozapine is indicated in individuals who fulfil the criteria for treatment-resistant schizophrenia, however, despite it being the most effective antipsychotic medication, there can be delays in the commencement of clozapine in eligible patients...
July 9, 2018: Early Intervention in Psychiatry
Michael C Hann, Evan Caporaso, George Loeffler, Adrian Cuellar, Lisa Herrington, Laura Marrone, Jong Yoon
AIM: Naval Medical Center San Diego's Psychiatric Transition Program is a specialized first episode psychosis treatment program that delivers coordinated specialty care to military service members with psychotic disorders. Due to the unique military environment, military service members with first episode psychosis are hypothesized to receive care very early after the emergence of first psychotic symptoms, resulting in significantly reduced duration of untreated psychosis. This study's aim is to calculate the duration of untreated psychosis for patients enrolled in Naval Medical Center San Diego's Psychiatric Transition Program (NMCSD PTP) from 01JUL2014-31DEC2016...
July 3, 2018: Early Intervention in Psychiatry
Barnaby Nelson, Emily Li, David C Cicero, Łukasz Gawęda, Jessica A Hartmann, Danny Koren, Andrea Polari, Thomas J Whitford, Suzie Lavoie
AIM: The Inventory of Psychotic-Like Anomalous Self-Experiences (IPASE) is a self-report measure of minimal self-disturbance. The aim of the current report was to assess the construct validity of the scale by examining its convergent validity with the gold-standard measure of minimal self-disturbance, the Examination of Anomalous Self-Experience (EASE), and its discriminant validity. METHOD: The sample consisted of 46 participants (21 ultra-high risk for psychosis patients, 14 first episode psychosis patients, 11 healthy controls)...
July 3, 2018: Early Intervention in Psychiatry
Michael Grossman, Michael W Best, Allyson G Harrison, Christopher R Bowie
AIM: Neurocognitive deficits are pervasive and enduring features of severe mental illness that appear before the onset of clinical symptoms and contribute to functional disability. However, it remains unclear how individuals who display warning signs for psychotic or mood disorders compare on their neurocognitive profiles since previous studies have separately examined neurocognition in both groups. Therefore, the purpose of this study was to directly compare performance on a range of neurocognitive tasks in individuals with emerging psychotic or mood symptoms...
July 3, 2018: Early Intervention in Psychiatry
Jan Sundquist, Karolina Palmér, Ashfaque A Memon, Xiao Wang, Leena M Johansson, Kristina Sundquist
BACKGROUND: Although mindfulness-based group therapies (MGTs) for depressive, anxiety or stress and adjustment disorders are promising, there is a substantial lack of knowledge regarding the long-term improvements after such therapies in these common psychiatric disorders. METHODS: Two hundred and fifteen patients were randomized in a randomized clinical trial (RCT) ( ID: NCT01476371) conducted in 2012 at 16 primary healthcare centres in southern Sweden...
July 3, 2018: Early Intervention in Psychiatry
Samantha Simpson, Lisa Phillips, Gennady Baksheev, Belinda Garner, Connie Markulev, Christina Phassouliotis, Mario Alvarez-Jimenez, Patrick McGorry, Sarah Bendall
AIM: Childhood trauma (CT), abuse and neglect are commonly reported by individuals experiencing psychosis. However, there are concerns that acute psychotic symptoms, in particular delusions, may contribute to inaccurate reporting of CT. As a result, individuals experiencing psychosis may not be asked about their experiences of abuse when they are being seen in psychiatric settings. This lack of attention can directly impact on the tailoring of their clinical care. This study aimed to investigate the stability of reports of CT by young people experiencing a first psychotic episode (FEP) compared to healthy comparison subjects...
July 3, 2018: Early Intervention in Psychiatry
Emma Caruana, John Farhall, Susan M Cotton, Emma Parrish, Kristi van-der-El, Christopher G Davey, Andrew M Chanen, Shayden D Bryce, Eoin Killackey, Kelly Allott
AIM: To compare rates of vocational engagement for youth entering specialist mental health treatment with the general population. METHODS: A file audit retrieved vocational data for 145 youth aged 15 to 25 entering treatment. Clinical and population data were stratified by age and sex and compared between cohorts. RESULTS: Compared to the population, young people entering mental health treatment were less likely to have completed at least Year 11 in school (77% vs 42%, P < 0...
July 3, 2018: Early Intervention in Psychiatry
Christi L Trask, Velma A Kameoka, Jason Schiffman, David C Cicero
AIM: Prior to the release of the fifth edition of the Diagnostic and Statistical Manual for Mental Disorders, experts in the field of psychosis research considered including a psychosis high-risk syndrome-attenuated psychosis syndrome-as a formal diagnosis. Opponents argued that such a diagnosis may increase the risk of stigmatization of individuals whose symptoms often remit. Although previous research has examined provider perceptions of attenuated psychosis syndrome, little work has focused on lay perceptions...
July 3, 2018: Early Intervention in Psychiatry
Karimah S Bell Lynum, Ibrahim Turkoz, Edward Kim
AIM: This post hoc analysis of a double-blind (DB), randomized, placebo-controlled, relapse-prevention study evaluated the effects of paliperidone palmitate once-every-3-months (PP3M) in a subpopulation of adults with early illness schizophrenia (duration ≤5 years) from a clinical trial. METHODS: Patients received either PP3M or placebo every 3 months in the DB phase. The primary efficacy variable was time from randomization to first relapse. Symptom severity, patient functioning, and safety were also assessed...
July 3, 2018: Early Intervention in Psychiatry
David C Rozek, Carol Keane, Lauren M Sippel, Jacob Y Stein, Cynthia Rollo-Carlson, Craig J Bryan
AIM: This study examined the short-term effects of a brief crisis intervention on optimism of acutely suicidal soldiers. METHODS: U.S. Soldiers (N = 97) presenting for an emergency mental health appointment in a military emergency department or behavioural health clinic were randomly assigned to treatment as usual standard crisis response plan, or enhanced crisis response plan (E-CRP). This study is used a subsample of the original clinical trial (n = 64) for those who completed self-report measures of optimism (Life Orientation Test-Revised) prior to receiving any intervention and a secondary self-report assessment one-month following the intervention...
June 26, 2018: Early Intervention in Psychiatry
Daniel J Devoe, Megan S Farris, Parker Townes, Jean Addington
AIM: Youth at clinical high risk (CHR) for psychosis often exhibit difficulties in social functioning and poorer social functioning may be predictive of transition to a psychotic disorder. Therefore, the primary objective of this systematic review was to summarize the impact of all interventions on social functioning in CHR samples. METHOD: Electronic databases PsycINFO, CINAHL, Embase, EBM, and MEDLINE were searched from 1951 to June 2017. Studies were selected if they included any intervention that reported changes in social functioning in youth at CHR...
June 25, 2018: Early Intervention in Psychiatry
Robin Martin, Marie Rose Moro, Laelia Benoit
AIM: A background of migration is an established risk factor for psychosis. At the same time, over the last 25 years, many countries have developed specialized services for the assessment and care of people with early psychosis. Evaluation of these services often focuses on the duration of untreated psychosis (DUP). METHODS: We conducted a systematic review with an electronic search of key words in 3 databases to determine the extent to which studies measuring DUP consider transcultural variables, including migration status, national origin, ethnicity and language...
June 21, 2018: Early Intervention in Psychiatry
Chen-Chung Liu, Yi-Ting Lin, Chih-Min Liu, Ming H Hsieh, Yi-Ling Chien, Tzung-Jeng Hwang, Hai-Gwo Hwu
AIM: Patient's long-term phenomenology after first-episode psychosis could be blurred due to early intervention. The contradictory messages regarding necessity of long-term antipsychotic treatment derived from different methodologies warrants careful reappraisal. METHODS: We approached a group of patients lost to follow-up in a previous study. Targeting these 44 missing patients, we sent 2 carefully worded letters to invite them for interviews to see if their life trajectories were different from those who stayed in a university-based hospital system...
June 21, 2018: Early Intervention in Psychiatry
Walter S Mathis, Scott Woods, Vinod Srihari
AIM: To apply spatial analytics to an underway first episode psychosis program to identify areas of significant variation in the geographical distribution of program enrollees from an underlying at-risk population. METHODS: Adaptive bandwidth kernel smoothing was used to estimate spatial density functions from program enrollee home addresses and a control population computed from US Census data. A relative risk surface derived from the ratio of these functions was used to discover under-represented areas, or areas from which fewer enrollees where produced than suggested by the underlying population density at the P < ...
June 21, 2018: Early Intervention in Psychiatry
Worku A Temesgen, Wai Tong Chien, Daniel Bressington
AIM: There is no standard definition of "subjective recovery" from psychosis, its nature is currently contested and debated among service-users and professionals. Individual studies have explored conceptualizations of subjective recovery from recent onset psychosis, but there have been no previously published systematic reviews on the topic. The aim of this review was to examine and synthesize quantitative and qualitative studies examining the concept of subjective recovery from recent onset psychosis and identify common factors associated with this recovery process...
June 21, 2018: Early Intervention in Psychiatry
Emma M Parrish, Nancy S Kim, Kristen A Woodberry, Michelle Friedman-Yakoobian
AIM: Schizophrenia is a highly stigmatized disorder. Identification of youth at high risk for psychosis has the potential for improved outcomes. However, identifying youth at risk could subject them to increased public stigma. Using an experimental vignette design, this study examined relative levels of public stigma elicited by the labels "schizophrenia," "clinical high risk (CHR)," "attenuated psychotic symptoms syndrome (APSS)," a label implying normative adolescent development ("a bad breakup"), and a no-label control condition...
June 21, 2018: Early Intervention in Psychiatry
Taciana C C Ragazzi, Rosana Shuhama, Paulo R Menezes, Cristina M Del-Ben
AIM: Epidemiological data have provided evidence that psychotic-like experiences (PLEs) can occur in the general population, not necessarily accompanied by the impairment and suffering observed in formal psychiatric diagnoses. According to the psychosis continuum hypothesis, PLEs would be subject to the same risk factors as frank psychosis. The aim of this review was to summarize observational studies that evaluated cannabis use as a risk factor for PLEs as determined by the Community Assessment of Psychic Experiences in non-clinical samples...
June 21, 2018: Early Intervention in Psychiatry
Mark van der Gaag, Liesbeth Eurelings-Bontekoe, Helga Ising, David van den Berg
AIMS: Childhood adversities combined with unsafe parenting may disturb personality development. This study investigated whether psychotic personality organization as defined by Kernberg and assessed with de Dutch Short Form of the MMPI (DSFM) is more prevalent in ultrahigh risk (UHR) for psychosis compared with non-psychotic psychiatric control patients (NPPC). METHODS: A total of 73 UHR and 119 NPPC patients were assessed with the DSFM and the Comprehensive Assessment of at Risk Mental States (CAARMS)...
June 19, 2018: Early Intervention in Psychiatry
Asiel Yair Adan Sanchez, Elizabeth McMillan, Amit Bhaduri, Nancy Pehlivan, Katherine Monson, Paul Badcock, Katherine Thompson, Eoin Killackey, Andrew Chanen, Brian O'Donoghue
AIM: This study aimed to determine the prevalence of high-risk sexual behaviours, sequelae and associated factors in young people attending a youth mental health service. METHODS: The study design was a cross-sectional survey of 103 young people aged between 15-25 years carried out across four specialist mental health clinics. A questionnaire on the sexual health of secondary level students was adapted for this study. Mental health symptomatology was assessed through the Brief Psychiatric Rating Scale (BPRS)...
June 19, 2018: Early Intervention in Psychiatry
Laelia Benoit, Patrick Cottin, Marie R Moro
AIM: Since 1999, the development of more than 100 "Maisons des Adolescents" (MDAs) has enabled young persons to gain access to specific care in integrated youth-friendly facilities in France. To contribute to the development and standardization of international youth-friendly health care services, this review provides insight into the French MDA facilities. METHODS: This socio-historical analysis includes a systematic review of articles referring to the MDAs (selection through title and/or abstract), ministry reports and newspaper articles, from 1999 to 2018...
June 13, 2018: Early Intervention in Psychiatry
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