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Cardiovascular Therapeutics

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https://www.readbyqxmd.com/read/28296232/inhibitors-of-soluble-epoxide-hydrolase-minimize-ischemia-reperfusion-induced-cardiac-damage-in-normal-hypertensive-and-diabetic-rats
#1
Oliul Islam, Prashanth Patil, Sumanta K Goswami, Rema Razdan, Mohammed N Inamdar, Mohammed Rizwan, Jubin Mathew, Bora Inceoglu, Kin S Stephen Lee, Sung H Hwang, Bruce D Hammock
AIM: We designed a study to evaluate the cardioprotective effect of two soluble epoxide hydrolase (sEH) inhibitors, 1-(1-propanoylpiperidin-4-yl)-3-(4-trifluoromethoxy)phenyl)urea (TPPU) and trans-4-{4-[3-(4-trifluoromethoxyphenyl)-ureido]cyclohexyloxy}benzoic acid (t-TUCB), in ischemia-reperfusion (IR) model. METHODS: Cardioprotective effects of the sEH inhibitors were evaluated against IR-induced myocardial damage in hearts from normal, hypertensive and diabetic rats using Langendorff's apparatus...
March 15, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28276175/population-level-incidence-and-monitoring-of-adverse-drug-reactions-with-long-term-amiodarone-therapy
#2
S Rankin, D H Elder, S Ogston, J George, C C Lang, A M Choy
INTRODUCTION: Amiodarone is associated with significant long-lasting adverse drug reactions (ADRs). Guidelines recommend laboratory monitoring during long-term use. However, data of compliance with laboratory monitoring is lacking. AIMS: The aim of this study was to assess laboratory monitoring of liver and thyroid function during amiodarone prescribing from 1989-2011 in the Tayside, UK, population (approximately 400,000) in relation to National guidelines recommending laboratory monitoring every 6 months...
March 9, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28261920/remote-physiological-ischemic-training-promotes-coronary-angiogenesis-via-molecular-and-cellular-mobilization-after-myocardial-ischemia
#3
Yu Zheng, Mingyue Xiao, Ling Li, Jianan Li, Jan D Reinhardt, Xiao Lu
AIM: This study was designed to explore the mechanism of physiological ischemic training (PIT) on remote limbs, with a special focus on the potential role of endothelial progenitor cells (EPCs), vascular endothelial growth factor (VEGF) and nitric oxide (NO) in local ischemic myocardium. METHOD: MI rabbit models were randomly assigned to sham-operated group (SO), training only group (TO), myocardial ischemia group (MI), PIT group, VEGF inhibitor group (VEGF-), NO inhibitor group (NO-), VEGF and NO inhibitor group (VEGF-/NO-), and EPC inhibitor group (EPC-)...
March 6, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28238219/prevalence-of-in-hospital-non-steroidal-anti-inflammatory-drug-exposure-in-patients-with-a-primary-diagnosis-of-heart-failure
#4
Paulino A Alvarez, David Putney, Richard Ogunti, Mamta Puppala, Cecilia Ganduglia, Guillermo Torre-Amione, Robert Schutt, Stephen Wong, Jerry D Estep
AIM: To determine the prevalence of in-hospital non-steroidal anti-inflammatory drug (NSAID) exposure and associated outcomes in patients admitted with a primary diagnosis of heart failure. METHODS: We performed a propensity-matched cohort analysis of patients admitted to Houston Methodist Hospital System with a primary diagnosis of heart failure according to the International Classification of Diseases-9-Clinical Modification (ICD-9-CM) from January 1(st) 2011 to December 31(st) 2014...
February 26, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28186689/enhanced-mrna-expression-of-plasminogen-activator-inhibitor-1-in-livedoid-vasculopathy-lesions
#5
Mehmet Agirbasli, Fatih Göktay, Irem Peker, Pembegul Gunes, Fugen Vardar Aker, Mustafa Akkiprik
AIM: Thrombosis and inflammation play an important role in pathophysiology of livedoid vasculopathy (LV). Plasminogen activator inhibitor-1 (PAI-1) is the main physiological inhibitor of fibrinolysis and is a pivotal modulator in a broad range of biological processes. METHOD: The study specimens were retrospectively selected from archives of pathology department. We investigated PAI-1 mRNA expression in the paraffin blocks of patients with biopsy proven LV and controls...
February 10, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28177198/the-tasmanian-atrial-fibrillation-study-transition-to-direct-oral-anticoagulants-2011-2015
#6
Endalkachew Admassie Alamneh, Leanne Chalmers, Luke R Bereznicki
INTRODUCTION: Contemporary Australian data regarding antithrombotic prescribing patterns following approval of direct oral anticoagulants (DOACs) in patients with atrial fibrillation (AF) are limited. AIM: The aim of the present study was to assess antithrombotic prescribing patterns before, during and after the clinical introduction of DOACs. METHODS: Using digital medical records, this retrospective cohort study included all patients with AF as a primary or secondary diagnosis who were admitted to the Royal Hobart Hospital, Tasmania, Australia, between January 2011 and July 2015...
February 8, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28129469/implantable-cardioverter-defibrillators-for-primary-prevention-in-patients-with-nonischemic-cardiomyopathy-a-systematic-review-and-meta-analysis
#7
Tamer Akel, James Lafferty
BACKGROUND: Implantable cardioverter defibrillators (ICDs) have proved their benefit in exerting favorable outcomes on survival in selected patients with cardiomyopathy. Although previous meta-analyses have shown benefit for their use in primary prevention, the evidence is less robust for patients with NICM in comparison to patients with CAD. OBJECTIVES: To evaluate the ability of ICD therapy in reducing all-cause mortality and sudden cardiac death (SCD) in patients with NICM...
January 27, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28118517/the-significance-of-the-washout-period-in-preconditioning
#8
Ruduwaan Salie, Amanda Lochner, Dirk J Loubser
Exposure of the heart to 5 min global ischaemia (I) followed by 5 min reperfusion (R) (ischaemic preconditioning, IPC) or transient Beta 2-adrenergic receptor (B2-AR) stimulation with formoterol (B2PC), followed by 5 min washout before index ischaemia, elicits cardioprotection against subsequent sustained ischaemia. Since the washout period during preconditioning is essential for subsequent cardioprotection, the aim of this study was to investigate the involvement of protein kinase A (PKA), reactive oxygen species (ROS), extracellular signal-regulated kinase (ERK), PKB/Akt, p38 MAPK and c-jun N-terminal kinase (JNK) during this period...
January 24, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28083915/effect-of-post-procedural-full-does-infusion-of-bivalirudin-on-acute-stent-thrombosis-in-patients-with-st-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention-outcomes-in-a-large-real-world-population
#9
Heyang Wang, Zhenyang Liang, Yi Li, Bin Li, Junming Liu, Xueyi Hong, Xin Lu, Jiansheng Wu, Wei Zhao, Qiang Liu, Jian An, Linfeng Li, Fanli Pu, Qiang Ming, Yaling Han
AIM: The current study aimed to evaluate the effect of prolonged full-does bivalirudin infusion in real-world population with ST-elevation Myocardial Infarction(STEMI). BACKGROUND: Subgroup data as well as meta analysis from randomized clinical trials have showed potency of post-procedural full dose infusion (1.75mg/kg/h) of bivalirudin on attenuating acute stent thrombosis(ST) after primary percutaneous coronary intervention(PCI). METHODS: In this multicenter retrospective observational study, 2047 consecutive STEMI patients treated with bivalirduin during primary PCI were enrolled in 65 Chinese centers between July 2013 and May 2016...
January 13, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28054461/comparative-efficacy-of-sirolimus-eluting-stents-and-paclitaxel-eluting-stents-in-east-asian-versus-non-east-asian-patients-a-systematic-review-meta-analysis
#10
Rui Zhao, Qianwei Lu, Rui Yang, Jianlin Du, Songbo Deng, Qiang She
BACKGROUND: First-generation drug-eluting stents - such as the sirolimus-eluting stent (SES) and paclitaxel-eluting stent (PES) - have become attractive options for percutaneous coronary intervention (PCI) and are still widely used in Asia. However, the effect of East Asian ethnicity on their efficacy remains unclear. METHODS: Pubmed, EMBASE, and the Cochrane Central Register of Controlled Trials were searched for randomized controlled trials comparing the efficacy of the Cypher SES and Taxus PES...
January 5, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28054454/epoetin-beta-pegol-ameliorates-flow-mediated-dilation-with-improving-enos-coupling-state-in-non-obese-diabetic-rats
#11
Kenichi Serizawa, Kenji Yogo, Yoshihito Tashiro, Ryohei Kawasaki, Koichi Endo, Yasushi Shimonaka, Michinori Hirata
BACKGROUND/AIMS: Patients with diabetic nephropathy have a high cardiovascular mortality. Epoetin beta pegol (continuous erythropoietin receptor activator, C.E.R.A.) is a drug for the treatment of renal anemia. In this study, we investigated the effect of C.E.R.A. on vascular endothelial function as evaluated by flow-mediated dilation (FMD) and the relationship between hematopoiesis and FMD in diabetic nephropathy rats. METHODS: Male Spontaneously Diabetic Torii rats (SDT, 22 weeks old) were used...
January 5, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28039944/hydrochlorothiazide-modulates-ischemic-heart-failure-induced-cardiac-remodeling-via-inhibiting-angiotensin-ii-type-1-receptor-pathway-in-rats
#12
Jinghong Luo, Xuanlan Chen, Chufan Luo, Guihua Lu, Longyun Peng, Xiuren Gao, Zhiyi Zuo
AIMS: Our previous study indicates that hydrochlorothiazide inhibits transforming growth factor (TGF)-β/Smad signaling pathway, improves cardiac function and reduces fibrosis. We determined whether these effects were common among the diuretics and whether angiotensin II receptor type 1 (AT1) signaling pathway played a role in these effects. METHODS: Heart failure was produced by ligating the left anterior descending coronary artery in adult male Sprague-Dawley rats...
December 31, 2016: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28039940/epac-rap1-activated-mesenchymal-stem-cells-improve-cardiac-function%C3%A2-in-rat-model-of-myocardial-infarction
#13
Irfan Khan, Anwar Ali, Muhammad Aleem Akhter, Nadia Naeem, Maqsood Ahmed Chotani, Hana'a Iqbal, Nurul Kabir, Mehnaz Atiq, Asmat Salim
INTRODUCTION: Rap1, a member of Ras superfamily of small GTP-binding proteins, is involved in cardiovascular biology in numerous ways. It is an evolutionary conserved regulator of adhesion, polarity, differentiation and growth. AIMS: Our aim was to analyze Rap1 activated rat bone marrow mesenchymal stem cells (MSCs) for their potential role in adhesion and cardiac differentiation. METHODS: Myocardial infarction (MI) was produced in Sprague Dawley (SD) rats through occlusion of the left anterior descending coronary artery...
December 31, 2016: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28039938/targeted-p2x7-r-shrna-delivery-attenuates-sympathetic-nerve-sprouting-and-ameliorates-cardiac-dysfunction-in-rats-with-myocardial-infarction
#14
Hongmei Gao, Jie Yin, Yugen Shi, Hesheng Hu, Xiaolu Li, Mei Xue, Wenjuan Cheng, Ye Wang, Xinran Li, Yongkang Li, Yu Wang, Suhua Yan
BACKGROUND: Inflammation-dominated sympathetic sprouting adjacent to the necrotic region following myocardial infarction (MI) has been implicated in the etiology of arrhythmias resulting in sudden cardiac death; however, the mechanisms responsible remain to be elucidated. Although P2X7 R is a key immune mediator, its role has yet to be explored. OBJECTIVE: We investigated whether P2X7 R regulates NF-κB and affects cardiac sympathetic reinnervation in rats undergoing MI...
December 31, 2016: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28039928/comparison-of-early-and-new-generation-drug-eluting-stent-implantations-for-ostial-right-coronary-artery-lesions
#15
Yusuke Watanabe, Kensuke Takagi, Toru Naganuma, Sunao Nakamura
BACKGROUND: Percutaneous coronary intervention (PCI) with early generation drug-eluting stent (eDES) implantation for ostial right coronary artery (RCA) lesions is challenging because of the frequent need for repeat revascularization. We compared mid-term clinical outcomes following eDES or new generation DES (nDES) implantation for ostial RCA lesions. METHODS: The study included 150 patients with ostial RCA lesions, 76 treated with eDES and 74 with nDES between January 2005 and September 2013...
December 31, 2016: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28039911/effective-suppression-of-atrial-fibrillation-by-the-antihistaminic-agent-antazoline-first-experimental-insights-into-a-novel-antiarrhythmic-agent
#16
Gerrit Frommeyer, Magdalena Sterneberg, Dirk G Dechering, Sven Kaese, Nils Bögeholz, Christian Pott, Michael Fehr, Harilaos Bogossian, Peter Milberg, Lars Eckardt
INTRODUCTION: The antihistaminic antazoline (ANT) was reported to be highly effective and safe for rapid conversion of atrial fibrillation (AF). We therefore analyzed underlying mechanisms in an experimental whole-heart model. METHODS AND RESULTS: Isolated and retrogradely perfused rabbit hearts underwent a standardized protocol employing atrial burst pacing induced AF in 5 of 20 hearts under baseline conditions (7 episodes). Thereafter, a combination of acetylcholine and isoproterenol was employed to enhance AF occurrence...
December 31, 2016: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/27860389/efficacy-and-safety-of-two-dosages-of-canrenone-as-add-on-therapy-in-hypertensive-patients-taking-ace-inhibitors-or-angiotensin-ii-receptor-blockers-and-hydrochlorothiazide-at-maximum-dosage-in-a-randomized-clinical-trial-the-escape-it-trial
#17
RANDOMIZED CONTROLLED TRIAL
Giuseppe Derosa, Pamela Maffioli, Maria D'Avino, Carla Sala, Amedeo Mugellini, Vito Vulpis, Salvatore Felis, Luigina Guasti, Riccardo Sarzani, Alessandro Bestetti, Massimo Vanasia, Giovanni Gaudio
AIM: To evaluate the effects of canrenone as add-on therapy in patients already treated with angiotensin-converting enzyme inhibitors (ACE-I) or angiotensin II receptor blockers (ARBs) and hydrochlorothiazide at the maximum dosage (25 mg/d). METHOD: In this randomized, open-label, controlled trial, we enrolled 175 Caucasian patients with essential hypertension not well controlled by concomitant ACE-I or ARBs and hydrochlorothiazide. At baseline, 87 patients (57 males and 30 females) were randomized to add canrenone 50 mg, and 88 (56 males and 32 females) patients to canrenone 100 mg, once a day, for 3 months...
February 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/27860332/ezetimibe-use-costs-and-adverse-events-in-australia
#18
Samantha A Hollingworth, Remo Ostino, Michael C David, Jennifer H Martin, Susan E Tett
AIM: To analyze the subsidized use and reported adverse events of ezetimibe, used to lower cholesterol, in Australia over the 11 years following its inclusion on the Pharmaceutical Benefits Scheme (PBS) in 2004. METHODS: Pharmacoepidemiological analysis of dispensed prescriptions from Medicare Australia. Adverse event data were obtained from the Therapeutic Goods Administration. Use was measured by the defined daily dose (DDD) per 1000 population per day for each calendar year...
February 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/27809414/salidroside-protects-against-homocysteine-induced-injury-in-human-umbilical-vein-endothelial-cells-via-the-regulation-of-endoplasmic-reticulum-stress
#19
Lin Zhu, Fang Jia, Jiang Wei, Yang Yu, Tianhong Yu, Yanjun Wang, Jianhui Sun, Guanghua Luo
INTRODUCTION: Previous studies showed that homocysteine (Hcy) could injure vascular endothelial cells via several mechanisms, including its promotion of oxidative stress pathway and endoplasmic reticulum stress (ER stress) pathway. Salidroside (SAL) is an active component of Rhodiola rosea with documented antioxidative properties. Emerging evidence conformed that SAL attenuated Hcy-induced endothelial dysfunction by reducing oxidative stress. However, its role in ER stress pathway remains unclarified...
February 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/27790832/platelet-activating-factor-a-potential-biomarker-in-acute-coronary-syndrome
#20
REVIEW
Anand Vijaya Kumar Palur Ramakrishnan, Treesa P Varghese, Sreedevi Vanapalli, Narayanan K Nair, Menge Denis Mingate
Platelet activating factor (PAF) is a potent pro-inflammatory negotiator that shows distinct spectrum of biological and pharmacological effects. Importantly, it participates in a wide range of pathophysiological conditions. In cardiovascular system, PAF has been shown to have an important role in platelet and neutrophil aggregation, vascular permeability, microvascular leakage, thrombus formation, leukocyte adhesion to the endothelial cells, and initiation and progression of atherosclerosis. The purpose of this article was to review the PAF, a family of lipids that is associated with the pathology of coronary artery diseases due to their association with leading etiological mechanisms such as inflammation, endothelial dysfunction, oxidative and nitrosative stress, and platelet reactivity...
February 2017: Cardiovascular Therapeutics
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