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Cardiovascular Therapeutics

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https://www.readbyqxmd.com/read/29771478/the-reverse-remodeling-response-to-sacubitril-valsartan-therapy-in-heart-failure-with-reduced-ejection-fraction
#1
Pieter Martens, Hanne Beliën, Matthias Dupont, Pieter Vandervoort, Wilfried Mullens
BACKGROUND: Major classes of medical therapy for heart failure with reduced ejection fraction (HFrEF) induce reverse remodeling. The revere remodeling response to sacubitril/valsartan remains unstudied. METHODS: We performed a single-center, prospective assessor-blinded study to determine the reverse remodeling response of sacubitril/valsartan-therapy in HFrEF-patients with a class I-indication (New York heart Association [NYHA]-class II-IV, Left ventricular ejection fraction [LVEF]<35%, optimal dose with Renin-Angiotensin-System-Blocker [RAS-blocker])...
May 17, 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29752864/%C3%AE-blockers-interfere-with-cell-homing-receptors-and-regulatory-proteins-in-a-model-of-spontaneously-hypertensive-rats
#2
Bruna Eibel, Melissa Kristochek, Thiago R Peres, Lucinara D Dias, Daniela R Dartora, Karina R Casali, Renato A K Kalil, Alexandre M Lehnen, Maria Claudia Irigoyen, Melissa M Markoski
AIM: To examine the interference of β-blockers with the chemokine stromal cell-derived factor-1 (SDF-1) found in cell homing receptors, C-X-C chemokine receptor type 4 (CXCR-4) and CXCR-7 and regulatory proteins of homing pathways, we administered atenolol, carvedilol, metoprolol and propranolol for 30 days using an orogastric tube to hypertensive rats. METHOD: We collected blood samples before and after treatment and quantified the levels of SDF-1 with enzyme linked immunosorbent assay (ELISA)...
May 12, 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29682911/detection-of-individual-responses-to-clopidogrel-validation-of-a-novel-rapid-analysis-using-teg-6s
#3
Bartosz Olechowski, Richard T Dalton, Vikram Khanna, Alexander Ashby, Maria Vavyla, Mark Mariathas, Scott Harris, Zoe Nicholas, Michael Mahmoudi, Nick Curzen
INTRODUCTION: There is potential value in testing individual response to P2Y12 inhibitors in order to predict ischaemic and bleeding risk in patients undergoing percutaneous coronary intervention. The aims of this study were:(a) to validate the ability of a novel point of care(POC) assay, TEG 6s, to detect changes in ADP-induced whole blood clotting in volunteers and patients given clopidogrel using TEG 5000 as a reference and (b) to compare a novel, rapid parameter, area under the curve at 15 minutes(AUC15), with the traditional maximum clot amplitude (MA) in TEG 6s...
April 22, 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29673103/allopurinol-and-endothelial-function-a-systematic-review-with-meta-analysis-of-randomized-controlled-trials
#4
Manal M Alem
AIM: Oxidative stress and endothelial dysfunction are two inter-related conditions commonly seen in patients with cardiovascular risk factors. The enzyme, xanthine oxidase, is an important contributor to these phenomena but to a variable degree in different patient populations. This meta-analysis will summarize the effect of allopurinol, an established xanthine oxidase inhibitor, on endothelial function among patients with different co-morbidities. METHODS: Medline Complete, PubMed, ProQuest, ClinicalKey, Wiley Online Library and Cochrane Central Register of Controlled Trials were searched till 29th July, 2017...
April 19, 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29656548/effects-of-geranylgeranylacetone-upon-cardiovascular-diseases
#5
Shengqiang Zeng, Hong Wang, Zaihua Chen, Qianqiang Cao, Lin Hu, Yanqing Wu
Heat shock proteins (HSPs) are an important family of protective proteins. They are involved actively in an array of cellular processes, including protective effects on the cardiovascular system in response to various stimuli. Increasing evidence shows that pharmacologic interventions that induce expression of HSPs may be a novel approach for the treatment of cardiovascular diseases. However, agents that induce expression of HSPs used previously are toxic or have harmful side effects, which limit their clinical application...
April 14, 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29608814/impact-of-high-implantation-on-functionality-of-self-expandable-bioprosthesis-during-the-short-and-long-term-outcome-of-patients-who-undergo-tavi-is-high-implantation-beneficial
#6
Manolis Vavuranakis, Maria Kariori, Lilly Scott, Konstantinos Kalogeras, Gerasimos Siasos, Dimitrios Vrachatis, Maria Lavda, Charalampos Kalantzis, Michael Vavuranakis, Evangelia Bei, Carmen-Maria Moldovan, Evangelos Oikonomou, Christodoulos Stefanadis, Dimitrios Tousoulis
AIM: High position of the self-expandable bioprosthesis CoreValve/Evolut R has been proved to affect immediate hemodynamics of the valve. Whether this may have any impact on long-term procedural outcome has not been defined yet. The purpose of this study is to assess whether the final position of aortic bioprosthesis affects its long-term functionality. METHOD: Consecutive patients (pts) who underwent successful TAVI procedure were evaluated and separated into two groups according to the implantation depth (ID); Group I: pts with 4mm<ID≤13 mm, Group II: pts with ID≤4mm...
April 2, 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29608244/microrna-181a-inhibits-ocular-neovascularization-by-interfering-with-vegf-expression
#7
Chun Yang, Houda Tahiri, Chenrongrong Cai, Muqing Gu, Carmen Gagnon, Pierre Hardy
AIM: Excess angiogenesis or neovascularization plays a key role in the pathophysiology of several ocular diseases such as retinopathy of prematurity, diabetic retinopathy and exudative age-related macular degeneration. MicroRNA-181a (miR-181a) was found highly expressed in retina and choroidal tissues. This study intends to investigate the role of miR-181a in the regulation of ocular neovascularization in different pathophysiological conditions. METHOD: We performed the RNA sequence to identify the microRNAs components of anti-angiogenic lymphocyte-derived microparticles (LMPs)...
April 2, 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29604187/investigating-the-possible-mechanisms-involved-in-adenosine-preconditioning-induced-cardioprotection-in-rats
#8
Lovedeep Singh, Jasleen Kaur Virdi, L N Maslov, Nirmal Singh, Amteshwar Singh Jaggi
BACKGROUND: Adenosine is a breakdown product of adenosine triphosphate and plays an important role in pharmacological preconditioning. The cardioprotective effects of adenosine preconditioning are well established. However, the possible mechanisms need to be explored. AIM: The present study was aimed to investigate the possible mechanisms involved in adenosine preconditioning-induced cardioprotection in rats. METHODS: Rat heart was isolated and perfused on Langendorff apparatus...
March 31, 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29493880/efficacy-and-safety-of-a-second-generation-biodegradable-polymer-sirolimus-eluting-stent-one-year-results-of-the-credit-2-trial
#9
Kai Xu, Yaling Han, Bo Xu, Yuejin Yang, Geng Wang, Hui Li, Yong Sun, Ling Tao, Haichang Wang, Zuyi Yuan, Huiliang Liu, Jinghua Liu, Yongping Jia, Genshan Ma, Guosheng Fu, Xiaodong Li, Shuren Li, Shouli Wang, Kui Pu
AIMS: We performed a multicenter, randomized controlled trial to determine the noninferiority of a novel biodegradable polymer drug-eluting stent (BP-DES), the EXCEL 2 stent, to the first-generation BP-DES, the EXCEL stent. METHODS AND RESULTS: Patients (n = 419) scheduled to undergo percutaneous coronary intervention (PCI) were randomized to receive either the EXCEL 2 stent (n = 208) or the EXCEL stent (n = 211) from 15 Chinese centers. At 9 months, primary endpoint in-stent late loss (LL) difference was -0...
June 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29485248/effects-of-combination-of-sotalol-and-verapamil-on-initiation-maintenance-and-termination-of-ventricular-fibrillation-in-swine-hearts
#10
Qi Jin, Liqun Wu, Derek J Dosdall, Li Li, Jack M Rogers, Raymond E Ideker, Jian Huang
INTRODUCTION: Sotalol and verapamil alone reduce reentry incidence during ventricular fibrillation (VF). We tested whether the combination of these two drugs had a synergistic effect on initiation, maintenance, and termination of VF. METHODS: Six open-chest pigs received intravenous sotalol (1.5 mg/kg) followed by verapamil (0.136 mg/kg). VF threshold (VFT) was determined by a burst pacing protocol. Two 20 seconds episodes of VF were recorded from a 21 × 24 unipolar electrode plaque on the lateral posterior left ventricular epicardium before and after each drug...
June 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29464937/vascular-dysfunction-elicited-by-a-cross-talk-between-periaortic-adipose-tissue-and-the-vascular-wall-is-reversed-by-pioglitazone
#11
Isabel Quesada, Jimena Cejas, Rodrigo García, Beatriz Cannizzo, Analía Redondo, Claudia Castro
AIM: Perivascular adipose tissue (PVAT) is in intimate contact with the vessel wall and extravascular PVAT-derived inflammatory mediators may adversely influence atherosclerotic plaque formation and stability through outside-to-inside signaling. We sought to investigate the role of PVAT on the atheroma development in an experimental animal model of metabolic syndrome (MS) associated with oxidative stress and low-grade inflammatory state. We also studied the effect of pioglitazone an insulin sensitizer, on the aortic wall and its surrounding PVAT, considering a bi-directional communication between both layers...
June 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29464917/head-to-head-comparison-of-the-heart-rate-variability-between-the-bisoprolol-transdermal-patch-and-bisoprolol-fumarate-tablet
#12
Akinori Sairaku, Yukiko Nakano, Nobuo Shiode, Kazuyoshi Suenari, Nozomu Oda, Koichi Ono, Yasuki Kihara
AIM: The bisoprolol transdermal patch is a newly developed β-blocker designed to deliver its pharmaceutical ingredient through the skin surface. We aimed to compare the bisoprolol transdermal patch and bisoprolol fumarate tablet using the heart rate variability (HRV). METHOD: Eligible hypertensive patients received a 2-week administration with a 2.5 mg bisoprolol fumarate tablet, followed by 24-hour Holter monitoring. The tablet was then switched to a 4 mg bisoprolol transdermal patch, and after 2 weeks of its administration, the Holter monitoring was repeated...
June 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29464863/change-in-alt-levels-after-administration-of-hmg-coa-reductase-inhibitors-to-subjects-with-pretreatment-levels-three-times-the-upper-normal-limit-in-clinical-practice
#13
Hyunah Kim, Hyeseon Lee, Tong Min Kim, So Jung Yang, Seo Yeon Baik, Seung-Hwan Lee, Jae-Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, In Young Choi, Kun-Ho Yoon, Hun-Sung Kim
AIM: Prescription of statins to patients with chronic liver disease whose alanine transaminase (ALT) is over three times the upper normal limit (UNL) is not recommended. In this study, we attempted to evaluate patients with baseline ALT levels > 3 ×  UNL who were prescribed statins without ethical problems, using electronic medical records. METHODS: We enrolled subjects with ALT levels > 3 ×  UNL. The patients were divided into three groups consisting of those who had been taking agents affecting liver function (HEPA) and continued to do so after the statin prescription (HepCon), those who had not previously taken HEPA and began doing so after statin prescription (HepNew), and those who had never taken HEPA (HepNo)...
June 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29352508/inhibition-of-brd4-attenuates-cardiomyocyte-apoptosis-via-nf-%C3%AE%C2%BAb-pathway-in-a-rat-model-of-myocardial-infarction
#14
Yiping Sun, Ying Xie, Luping Du, Jingwu Sun, Zhiqiang Liu
BACKGROUND: Myocardial infarction (MI) remains the most common cause of heart failure (HF) worldwide. For almost 50 years, HF has been recognized as a determinant of adverse prognosis after MI, but efforts to promote myocardial repair have failed to be translated into clinical therapies. AIMS: In this study, we investigated the effects of BRD4 on cardiac function and the underlying mechanism. MATERIAL AND METHODS: The in vivo rat model of AMI and in vitro neonatal cardiomyocytes were established and cultured respectively, the BRD4 and NPPA/NPPB expression levels were detected by qPCR and Western blot, and interaction of BRD4 with acetylation RelA or NPPA/B promoters were examined by co-immunoprecipitation and chromatin immunoprecipitation assays, respectively...
April 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29316284/a-propensity-score-matched-comparison-of-biodegradable-polymer-vs-second-generation-durable-polymer-drug-eluting-stents-in-a-real-world-population
#15
Ying Jiao Zhao, Monica Teng, Ai Leng Khoo, Rajiv Ananthakrishna, Tiong Cheng Yeo, Boon Peng Lim, Joshua P Loh, Mark Y Chan
AIMS: The safety and efficacy of BP-DES compared to second-generation DP-DES remain unclear in the real-world setting. We compared the clinical outcomes of biodegradable polymer drug-eluting stents (BP-DES) with second-generation durable polymer drug-eluting stents (DP-DES) in an all-comer percutaneous coronary intervention (PCI) registry. METHODS/RESULTS: The study included a cohort of 1065 patients treated with either BP-DES or DP-DES from January 2009 through October 2015...
April 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29288528/overexpression-of-mir-22-attenuates-oxidative-stress-injury-in-diabetic-cardiomyopathy-via-sirt-1
#16
Qinghui Tang, Qiang Len, Zheng Liu, WeiDong Wang
BACKGROUND/AIMS: Oxidative stress injury is believed to be important in diabetic cardiomyopathy. Recent evidence indicates that miR-22 plays an important role in various cardiovascular diseases, but the protective role of miR-22 in diabetic cardiomyopathy remains undetermined. METHODS: Diabetes was induced in male C57BL/6 mice by intraperitoneal injection with streptozotocin combined with a high-fat diet, and miR-22 was overexpressed following transfection with adeno-associated virus...
April 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29283509/exenatide-exhibits-anti-inflammatory-properties-and-modulates-endothelial-response-to-tumor-necrosis-factor-%C3%AE-mediated-activation
#17
Wojciech Garczorz, Enrique Gallego-Colon, Agnieszka Kosowska, Agnieszka Kłych-Ratuszny, Michał Woźniak, Wiesław Marcol, K J Niesner, Tomasz Francuz
INTRODUCTION: Cardiovascular disease is the main cause of mortality and morbidity in the industrialized world. Incretin-mimetic compounds such as exenatide are currently used in the treatment of type 2 diabetes. AIMS: We investigated the effects of incretin drugs on apoptosis, adhesion molecule expression, and concentration of extracellular matrix (ECM) metalloproteinases under inflammatory conditions within the context of atherosclerotic plaque formation of both human coronary artery endothelial cells (hCAECs) and human aortic endothelial cells (hAoECs)...
April 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29283501/nicorandil-for-the-prevention-of-contrast-induced-nephropathy-a-meta-analysis-of-randomized-controlled-trials
#18
Xiaofen Ma, Xiang Li, Zhanfeng Jiao, Yiming Zhang
INTRODUCTION: Nicorandil has been suggested as a preventative strategy against the incidence of contrast-induced nephropathy (CIN). However, results of relevant randomized controlled trials (RCTs) were inconsistent. AIMS: We performed a meta-analysis of RCTs to evaluate the preventive efficacy of periprocedural treatment of nicorandil against the incidence of CIN. METHODS: Relevant RCTs were identified via search of PubMed, Embase, and Cochrane's Library databases...
April 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29243335/comparative-performance-of-pharmacogenetics-based-warfarin-dosing-algorithms-derived-from-caucasian-asian-and-mixed-races-in-thai-population
#19
Supatat Chumnumwat, Kong Yi, Aroonrut Lucksiri, Wichit Nosoongnoen, Busba Chindavijak, Suvatna Chulavatnatol, Ajjima Sarapakdi, Surakit Nathisuwan
AIM: This study was conducted to compare predictive accuracy of the available pharmacogenetics (PGx)-guided warfarin dosing algorithms derived from Caucasian, Asian, and mixed population to identify a suitable algorithm for Thai population. METHODS: Ten warfarin dosing algorithms derived from different population including Caucasian, East Asian, South-East Asian, and mixed races were selected and tested with clinical and genetic data of Thai patients. Comparative performances of these algorithms were tested using mean dose error (MDE) between actual warfarin maintenance dose (AWMD) and predicted dose generated by each dosing algorithm, and percentage of ideal dose prediction (IDP)...
April 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29460403/effects-of-ivabradine-on-endothelial-function-aortic-properties-and-ventricular-arterial-coupling-in-chronic-systolic-heart-failure-patients
#20
Ivano Bonadei, Edoardo Sciatti, Enrico Vizzardi, Davide Fabbricatore, Mattia Pagnoni, Laura Rossi, Valentina Carubelli, Carlo M Lombardi, Marco Metra
AIM: Heart rate (HR) is an important prognostic factor in patients affected by chronic heart failure (CHF); ivabradine has been demonstrated to significantly reduce nonfatal myocardial infarction and hospitalization rate for acute heart failure and to improve left ventricular (LV) reverse remodeling, quality of life, exercise capacity, and arterial elastance (Ea) in these patients. We aimed at evaluating the short-term effects of ivabradine on ventricular-arterial coupling (VAC), aortic stiffness, and endothelial function in stable patients with CHF...
February 20, 2018: Cardiovascular Therapeutics
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