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Archives of Osteoporosis

Gulzhan Gabdulina, Melody Kasher, Aliya Beissebayeva, Dana Mussabaeva, Alexander Tokarev, Gulmira Mominova, Gulnar Essirkepova, Ainash Amanzholova, Korlan Zaurbekova, Maira Saparbaeva, Maira Bizhanova, Moldir Kulshymanova, Gregory Livshits
PURPOSE: We aimed to assess which of the major risk factors associated with rheumatoid arthritis (RA) severity are also associated with osteoporosis-related phenotypes (OP-RP) in the native population of Kazakhstan. METHODS: Four hundred six RA patients (90.6% females) with 397 controls-unaffected first-degree relatives were recruited. Biochemical factors were recorded, and OP-RP were assessed using QCT scans and ultrasound densitometry (US) of the forearm to estimate cortical indices (CI), spongial bone mineral density (BMDSPN ), and US_T-scores...
September 19, 2018: Archives of Osteoporosis
Andrea Ildiko Gasparik, Gabriela Mihai, Charlotte Beaudart, Olivier Bruyère, Raluca-Monica Pop, Jean-Yves Reginster, Ionela Maria Pascanu
The name and surname of the authors have been inverted. The correct order would be like this: Andrea Ildiko Gasparik, Gabriela Mihai, Charlotte Beaudart, Olivier Bruyere, Raluca-Monica Pop, Jean-Yves Reginster, Ionela Maria Pascanu.
September 17, 2018: Archives of Osteoporosis
Daniel Prieto-Alhambra, Carlen Reyes, Miguel Sanz Sainz, Jesús González-Macías, Luis Gracia Delgado, Cristina Alonso Bouzón, Sarah Mills Gañan, Damián Mifsut Miedes, Eduardo Vaquero-Cervino, Manuel Francisco Bravo Bardaji, Laura Ezquerra Herrando, Fátima Brañas Baztán, Bartolomé Lladó Ferrer, Ivan Perez-Coto, Gaspar Adrados Bueno, Jesús Mora-Fernandez, Teresa Espallargas Doñate, Jorge Martínez-Iñiguez Blasco, Ignacio Aguado-Maestro, Pilar Sáez-López, Monica Salomó Doménech, Vicente Climent-Peris, Ángel Díez Rodríguez, Humberto Kessel Sardiñas, Óscar Tendero Gómez, Jordi Teixidor Serra, José Ramón Caeiro-Rey, Ignacio Andrés Cano, Mariano Barrés Carsi, Iñigo Etxebarria-Foronda, Juan Dionisio Avilés Hernández, Juan Rodriguez Solis, Oscar Torregrosa Suau, Xavier Nogués, Antonio Herrera, Adolfo Díez-Perez
We have characterised 997 hip fracture patients from a representative 45 Spanish hospitals, and followed them up prospectively for up to 4 months. Despite suboptimal surgical delays (average 59.1 hours), in-hospital mortality was lower than in Northern European cohorts. The secondary fracture prevention gap is unacceptably high at 85%. PURPOSE: To characterise inpatient care, complications, and 4-month mortality following a hip or proximal femur fracture in Spain. METHODS: Design: prospective cohort study...
September 14, 2018: Archives of Osteoporosis
Adam J Kuchnia, Yosuke Yamada, Levi Teigen, Diane Krueger, Neil Binkley, Dale Schoeller
RATIONALE: Fluid volume estimates may help predict functional status and thereby improve sarcopenia diagnosis. MAIN RESULT: Bioimpedance-derived fluid volume, combined with DXA, improves identification of jump power over traditional measures. SIGNIFICANCE: DXA-measured lean mass should be corrected for fluid distribution in older populations; this may be a surrogate of muscle quality. PURPOSE: Sarcopenia, the age-related loss of muscle mass and function, negatively impacts functional status, quality of life, and mortality...
September 14, 2018: Archives of Osteoporosis
Zongshan Hu, Gene C W Man, Anthony K L Kwok, Sheung-Wai Law, Winnie W C Chu, Wing-Hoi Cheung, Yong Qiu, Jack C Y Cheng
We compared global sagittal alignment and quality of life in osteoporotic patients with and without vertebral compression fracture (VCF) and determined its relationship with VCF severity. The findings revealed osteoporotic patients with VCF showed decreased quality of life and worse global sagittal alignment, which was significantly associated with VCF severity. INTRODUCTION: The aim of this study was to compare the global sagittal alignment and quality of life in elderly osteoporotic patients with and without vertebral compression fracture (VCF), and to investigate the relationship between global sagittal alignment and severity of VCF...
September 7, 2018: Archives of Osteoporosis
Tomohiro Yoshizawa, Tomofumi Nishino, Ichiro Okubo, Masashi Yamazaki
This study's purpose was to clarify the cost-effectiveness of osteoporosis treatment. Denosumab treatment was cost-effective compared with alendronate treatment for elderly Japanese women at high risk of fragility fractures. Denosumab treatment might be cost-effective for patients with lower bone mineral density. PURPOSE: In Japan's super-aged society, the prevention and treatment of osteoporosis are a critical issue with implications for the medical economy. This study's purpose was to clarify the cost-effectiveness of osteoporosis treatment with denosumab versus weekly alendronate for elderly Japanese women at high risk of fragility fractures...
August 29, 2018: Archives of Osteoporosis
Giulia Rodari, G Scuvera, F M Ulivieri, E Profka, F Menni, V Saletti, S Esposito, S Bergamaschi, E Ferrante, C Eller-Vainicher, S Esposito, M Arosio, C Giavoli
Bone density impairment represents an established complication in adults with neurofibromatosis type 1, while few data exist in the pediatric population. Age- and gender-adjusted bone mass decreases with age and pubertal development, identifying childhood as the best time frame to introduce prevention strategies aiming at peak bone mass achievement. PURPOSE: The present study aims at evaluating bone mineral density (BMD) in a population of children with neurofibromatosis type I (NF-1), with particular focus on changes occurring during growth and pubertal development...
August 27, 2018: Archives of Osteoporosis
Shahab Abtahi, Johanna H M Driessen, Peter Vestergaard, Joop van den Bergh, Annelies Boonen, Frank de Vries, Andrea M Burden
We investigated the incidence trend in all major osteoporotic fractures for the whole country of Denmark between 1995 and 2010. Hip and other osteoporotic fractures declined for the general population and especially among women. But, we observed some increasing trend among men which needs more attention. PURPOSE: The trend in osteoporotic fractures is varied across the globe, and there is no updated information in the case of Denmark for all major osteoporotic fractures (MOF). Thus, we investigated the incidence rates (IRs) of MOF among 50+ adults in Denmark over the period 1995-2010...
August 27, 2018: Archives of Osteoporosis
Pedro F Saint-Maurice, Kelly Laurson, Gregory J Welk, Joe Eisenmann, Luis Gracia-Marco, Enrique G Artero, Francisco Ortega, Jonatan R Ruiz, Luis A Moreno, German Vicente-Rodriguez, Kathleen F Janz
The National Academy of Medicine recommends the handgrip for school-based surveillance of muscle strength for bone health. We established grip strength cutpoints that are linked to bone health in both US and European youth. These cutpoints could serve as a potential set of standards for surveillance and clinical applications. PURPOSE: The U.S. National Academy of Medicine and experts in Europe recommend the use of grip strength as a valuable and accessible musculoskeletal fitness measure due to its association with bone health...
August 27, 2018: Archives of Osteoporosis
Ben-Hur Albergaria, Monique Chalem, Patricia Clark, Osvaldo Daniel Messina, Rosa Maria R Pereira, Luis F Vidal
BACKGROUND: Osteoporosis is a common disorder affecting populations worldwide. In Latin America, an aging population combined with limited health care resources result in osteoporosis quickly becoming a condition of considerable magnitude with disproportionate morbidity and mortality. AIM: To review the current state of prevention, diagnosis, and treatment of osteoporosis in Latin America and to develop strategies and recommendations that may be adopted in the region, an expert panel of clinicians and scientists was assembled to develop a consensus statement outlining future directions...
August 24, 2018: Archives of Osteoporosis
Joshua E Johnson, Karen L Troy
Though smokers have poor clinical outcomes after treatment for fractures, the skeletal effects of smoking are still debated. Our results showed that female smokers had 33% higher cortical bone porosity. Smoking targets cortical compartment microstructure and mechanics, and micron-scale variables are essential to better understand the specific effects of smoking. PURPOSE: Smokers have poor outcomes in the clinic after treatment for fractures. However, skeletal effects of smoking are still debated...
August 23, 2018: Archives of Osteoporosis
Jung Eun Yoo, Hye Soon Park
Osteoporosis has become an important health concern even in men. We aimed to analyze its prevalence and associated factors in Korean men. Low socioeconomic status, unhealthy lifestyle, and chronic kidney disease increased the risk. High-risk men even at young age need to evaluate bone mineral density, and proper interventions should be reinforced. PURPOSE: Owing to an increase in the elderly population, osteoporosis and consequent fractures have become important health concerns even in men...
August 20, 2018: Archives of Osteoporosis
R White, N Binkley, D Krueger
Degenerative changes falsely elevate BMD; however, their impact on TBS is unclear. This study examined how spinal degenerative changes affect TBS-adjusted fracture risk (FRAX). In a majority, but not all patients in this sample, TBS decreased after exclusion of vertebrae with degenerative change. Therefore, vertebral exclusion for TBS is suggested. INTRODUCTION: Spinal degenerative changes elevate DXA-measured BMD, but reports find trabecular bone score (TBS) relatively unaffected. However, we observed patients where degenerative changes elevated both...
August 20, 2018: Archives of Osteoporosis
Namki Hong, Chang Oh Kim, Yoosik Youm, Jin-Young Choi, Hyeon Chang Kim, Yumie Rhee
In a community-dwelling elderly cohort, dysmobility syndrome was associated with elevated odds of morphometric vertebral fracture or any prevalent fracture, independent of age and covariates. Dysmobility syndrome improved discrimination for fracture when added to the FRAX score. INTRODUCTION: Dysmobility syndrome was coined to indicate patients with impaired musculoskeletal health. Data on the association of dysmobility syndrome with prevalent morphometric vertebral fracture (VF) in elderly persons are limited...
August 14, 2018: Archives of Osteoporosis
Stuart L Silverman, E Siris, D Belazi, C Recknor, A Papaioannou, J P Brown, D T Gold, E M Lewiecki, G Quinn, A Balasubramanian, S Yue, B Stolshek, D L Kendler
Persistence with prescribed medications for chronic diseases is important; however, persistence with osteoporosis treatments is historically poor. In this prospective cohort study of postmenopausal women treated for osteoporosis in real-world clinical practice settings in the USA and Canada, 24-month persistence with denosumab was 58%. PURPOSE: Patients who persist with their prescribed osteoporosis treatment have increased bone mineral density (BMD) and reduced risk of fracture. Twelve-month persistence with denosumab in routine clinical practice is as high as 95%, but there are limited data on longer-term persistence with denosumab in this setting...
August 7, 2018: Archives of Osteoporosis
Zuha Jeddy, Jonathan H Tobias, Ethel V Taylor, Kate Northstone, W Dana Flanders, Terryl J Hartman
Prenatal exposures to perfluoroalkyl substances (PFAS) have been associated with developmental outcomes in offspring. We found that prenatal concentrations of some PFAS may be associated with reduced bone mass and size in 17-year-old British girls, although it is not clear whether these associations are driven by body size. PURPOSE: PFAS are used to make protective coatings on common household products. Prenatal exposures have been associated with developmental outcomes in offspring. Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), we investigated the association between prenatal concentrations of PFAS and bone health in girls at 17 years of age and whether body composition can explain any associations...
August 3, 2018: Archives of Osteoporosis
SoJung Kim, Breanne S Baker, Pragya Sharma-Ghimire, Debra A Bemben, Michael G Bemben
The aim of this study was to determine if bone-specific physical activity questionnaire (BPAQ) scores were positively related to bone health in healthy young and middle-aged premenopausal women. The total BPAQ was a stronger predictor of bone strength and bone mineral density of hip in young women as compared to middle-aged premenopausal women. PURPOSE: The purpose of this study was to determine whether the BPAQ scores were predictive indices of volumetric BMD (vBMD), bone strength, and bone geometry in young and middle-aged premenopausal women...
July 28, 2018: Archives of Osteoporosis
Henrik Teuber, Simon Tiziani, Sascha Halvachizadeh, Diana Frey, Kai Sprengel, Hans-Christoph Pape, Georg Osterhoff
This matched case-control study compared the rate of symptomatic adjacent-level vertebral compression fractures (VCF) within 1 year in patients operatively treated with kyphoplasty to a control group of non-operatively treated VCFs. The adjacent-level fracture rate did not show a significant difference between groups. PURPOSE: To compare the rate of new symptomatic adjacent-level fractures within 1 year after an isolated osteoporotic vertebral compression fracture (VCF) treated by either kyphoplasty or non-operative treatment...
July 27, 2018: Archives of Osteoporosis
Fátima Brañas, A Ruiz-Pinto, E Fernández, A Del Cerro, R de Dios, L Fuentetaja, L Cebrián, R Larrainzar-Garijo
Hip fracture is a major health care problem worldwide. Business process management systems (PMSs) have made significant contributions in health care environments to improve patient care standards. The effectiveness of PMS applied to hip fracture in older adults in the acute phase has been demonstrated. INTRODUCTION: Fragility fracture is a major health care problem worldwide. Business PMSs have made significant contributions in health care environments to improve patient care standards...
July 25, 2018: Archives of Osteoporosis
Herng-Sheng Lee, Chi-Yi Chen, Wan-Ting Huang, Li-Jen Chang, Solomon Chih-Cheng Chen, Hsin-Yi Yang
This study was to investigate the fracture risk of irritable bowel syndrome (IBS) in comparison with non-IBS group. Our results found that IBS group has increased risk for fracture, in particular of the spine, forearm, hip, and hand. INTRODUCTION: Patients with IBS might also be at increased risk of osteoporosis and osteoporotic fractures. Up to now, the association between IBS and the risk of fractures at different anatomic sites occurrences is not completely clear. We conducted a population-based cohort analysis to investigate the fracture risk of IBS in comparison with non-IBS group...
July 21, 2018: Archives of Osteoporosis
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