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Pigment Cell & Melanoma Research

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https://www.readbyqxmd.com/read/28649789/beyond-mitf-multiple-transcription-factors-directly-regulate-the-cellular-phenotype-in-melanocytes-and-melanoma
#1
REVIEW
Hannah E Seberg, Eric Van Otterloo, Robert A Cornell
MITF governs multiple steps in the development of melanocytes, including specification from neural crest, growth, survival, and terminal differentiation. In addition, the level of MITF activity determines the phenotype adopted by melanoma cells, whether invasive, proliferative, or differentiated. However, MITF does not act alone. Here we review literature on the transcription factors that co-regulate MITF-dependent genes. ChIP-seq studies have indicated that the transcription factors SOX10, YY1, and TFAP2A co-occupy subsets of regulatory elements bound by MITF in melanocytes...
June 26, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28646617/melanoma-associated-grm3-variants-dysregulate-melanosome-trafficking-and-camp-signaling
#2
Ana Neto, Craig J Ceol
Large-scale sequencing studies have revealed several genes that are recurrently mutated in melanomas. To annotate the melanoma genome we have expressed tumor-associated variants of these genes in zebrafish and characterized their effects on melanocyte development and function. Here, we describe expression of tumor-associated variants of the recurrently-mutated metabotropic glutamate receptor 3 (GRM3) gene. Unlike wild-type GRM3, tumor-associated GRM3 variants disrupted trafficking of melanosomes, causing their aggregation in the cell body...
June 24, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28640957/restoration-of-cutaneous-pigmentation-by-transplantation-to-mice-of-isogeneic-human-melanocytes-in-dermal-epidermal-engineered-skin-substitutes
#3
Steven T Boyce, Christopher M Lloyd, Mark C Kleiner, Viki B Swope, Zalfa Abdel-Malek, Dorothy M Supp
Autologous engineered skin substitutes (ESS) containing melanocytes (hM) may restore pigmentation, and photoprotection after grafting to full-thickness skin wounds. In the current study, normal hM were isolated from discard skin, propagated with or without tyrosinase inhibitors, cryopreserved, recovered into culture, and added to ESS (ESS-P) before transplantation. ESS-P were incubated in either UCMC160/161 or UCDM1 medium, scored for hM densities, and grafted to mice. The results showed that: sufficient hM can be propagated to expand donor tissue by 100-fold; incubation of hM in tyrosinase inhibitors reduced pigment levels but did not change hM recovery after cryopreservation; hM densities in ESS-P were greater after incubation in UCDM1 than UCMC160 medium; hM were localized to the dermal-epidermal junction of ESS-P; and UCDM1 medium promoted earlier pigment distribution and density...
June 22, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28640947/clinico-molecular-analysis-of-eleven-patients-with-hermansky-pudlak-type-5-syndrome-a-mild-form-of-hps
#4
Vincent Michaud, Eulalie Lasseaux, Claudio Plaisant, Alain Verloes, Yaumara Perdomo-Trujillo, Christian Hamel, Nursel H Elcioglu, Bart Leroy, Josseline Kaplan, Pierre-Simon Jouk, Didier Lacombe, Patricia Fergelot, Fanny Morice-Picard, Benoit Arveiler
Hermansky-Pudlak syndrome (HPS), first described in 1959, is a rare form of syndromic oculocutaneous albinism associated with bleeding diathesis and in some cases pulmonary fibrosis and granulomatous colitis. All 10 HPS types are caused by defects in vesicle trafficking of lysosomes-related organelles (LRO) proteins. The HPS5 protein associates with HPS3 and HPS6 to form the Biogenesis of Lysosome-related Organelles Complex-2 (BLOC-2). Here we report the clinical and genetic data of 11 HPS-5 patients analyzed in our laboratory...
June 22, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28640512/a-major-responder-to-ipilimumab-and-nivolumab-in-metastatic-uveal-melanoma-with-concomitant-autoimmunity
#5
Pui Ying Chan, Peter Hall, Gordon Hay, Victoria M L Cohen, Peter W Szlosarek
The use of immune checkpoint inhibition has led to major improvements in outcome for patients with metastatic cutaneous melanoma. The combination of ipilimumab and nivolumab has demonstrated greater activity over single agent immunotherapy in phase III trials. Clinical trials of combination CTLA-4 and PD-1 inhibition are underway in uveal melanoma, for which there are currently no data. Here, we present the case of a 74-year-old male patient with metastatic uveal melanoma, who was treated with a combination of ipilimumab and nivolumab...
June 22, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28627081/arginase-2-a-mir-1299-target-enhances-pigmentation-in-melasma-by-reducing-melanosome-degradation-via-senescence-induced-autophagy-inhibition
#6
Nan-Hyung Kim, Soo-Hyun Choi, Nayoung Yi, Tae Ryong Lee, Ai-Young Lee
Expression profiles revealed miR-1299 downregulation concomitant with arginase-2 (ARG2) upregulation in hyperpigmented skin of melasma patients. Opposite regulation of tyrosinase and PMEL17 by miR-1299 and inverse relationship between miR-1299 and ARG2 expression denoted a role of miR-1299 in pigmentation with ARG2 as a miR-1299 target. ARG2 overexpression or knockdown in keratinocytes, the main source of ARG2 in epidermis, positively regulated tyrosinase and PMEL17 protein levels, but not mRNA levels or melanosome transfer...
June 19, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28627072/reply-to-clinical-and-therapeutic-implications-of-braf-mutation-heterogeneity-in-metastatic-melanoma-by-mesbah-ardakani-et-al
#7
LETTER
Amélie Boespflug, Elisa Funck-Brentano, Zofia Hélias-Rodzewicz, Delphine Maucort-Boulch, Alain Beauchet, Pierre-Paul Bringuier, Charles Dumontet, Jean-François Emile, Philippe Saiag, Stéphane Dalle
Like Mesbah Ardakani et al. we investigated the impact of BRAF V600E allele frequency (AF) on progression free survival (PFS) and overall survival (OS) in patients treated by BRAF inhibitors used as single agents for advanced or metastatic melanoma but we used a larger retrospective cohort with 78 patients enrolled in two skin cancer centers. Because BRAF mutation has a heterozygous pattern, we set the cutoff to separate high and low BRAF AF at 60%, in accordance to our previous work on this subject. Like Mesbah Ardakani et al...
June 19, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28581208/pigmentation-more-than-one-master
#8
Erna Magnúsdóttir
Vertebrate pigmentation is a process directed by various transcriptional regulators, that drive the specification of melanoblasts from neural crest cells, their proliferation and migration, and terminal differentiation into melanocytes, culminating in the generation of pigment and it's distribution to surrounding keratinocytes. The transcription factor MITF has been coined the "master regulator" of melanocyte development (reviewed in (Steingrímsson, Copeland and Jenkins, 2004)), as it drives both the specification and differentiation of melanocytes...
June 5, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28581198/fbxw7-inactivation-in-a-braf-v600e-driven-mouse-model-leads-to-melanoma-development
#9
LETTER
Iraz T Aydin, Franco Abbate, Geena Susan Rajan, Brateil Badal, Iannis Aifantis, Garrett Desman, Julide Tok Celebi
Human melanocytic nevi driven by BRAF(V)(600E) are in a growth-arrested state referred as oncogene-induced senescence. FBXW7 tumor suppressor is mutated in melanomas, but not in benign precursor melanocytic nevi. In order to characterize whether inactivation of FBXW7 in cooperation with BRAF(V)(600E) (Braf(V637E) in the mouse) is sufficient to bypass from the growth-arrested state, we generated a murine model by conditionally silencing Fbxw7 in an established system, Tyr::CreER; Braf(CA) (or Tyr::CreER; Braf(V600E) )...
June 5, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28544727/ultraviolet-radiation-accelerates-nras-mutant-melanomagenesis-a-cooperative-effect-blocked-by-sunscreen
#10
Rebecca C Hennessey, Andrea M Holderbaum, Anamaria Bonilla, Conor Delaney, James E Gillahan, Kathleen L Tober, Tatiana M Oberyszyn, Jonathan H Zippin, Christin E Burd
To mitigate melanoma risk, sunscreen use is widely advocated; yet, the ability of sunscreens to prevent melanoma remains controversial. Here, we test the tenet that sunscreens limit melanoma risk by blocking ultraviolet radiation (UV)-induced DNA damage using murine models that recapitulate the genetics and spontaneous evolution of human melanoma. We find that a single, non-erythematous dose of UV dramatically accelerates melanoma onset and increases tumor multiplicity in mice carrying an endogenous, melanocyte-specific NRas(61R) allele...
May 24, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28544808/the-first-transepidermal-transplantation-of-non-cultured-epidermal-suspension-using-a-dermarolling-system-in-vitiligo-a-sequential-histological-and-clinical-study
#11
L Benzekri, Y Gauthier
The current methods for melanocyte delivery to depigmented skin are invasive and often require sophisticated approaches. Here we describe a promising simple and minimally invasive technique based on the dermarolling system. The technique involves preparation of a keratinocyte/melanocyte suspension prepared by trypsinization from a non-lesioned part of a patient's scalp skin and transepidermal delivery using a dermaroller equipped with 0.2 mm needles. Dermarolling leads to epidermal microinjuries without, however, causing pain or inflammation...
May 19, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28513992/immunoregulatory-protein-b7-h3-promotes-growth-and-decreases-sensitivity-to-therapy-in-metastatic-melanoma-cells
#12
Karine Flem-Karlsen, Christina Tekle, Yvonne Andersson, Kjersti Flatmark, Øystein Fodstad, Caroline E Nunes-Xavier
B7-H3 (CD276) belongs to the B7-family of immunoregulatory proteins, and has been implicated in cancer progression and metastasis. In this study, we found that metastatic melanoma cells with knockdown expression of B7-H3 showed modest decrease in proliferation and glycolytic capacity, and were more sensitive to dacarbazine (DTIC) chemotherapy and small-molecule inhibitors targeting MAP kinase (MAPK)- and AKT/mTOR-pathways: vemurafenib (PLX4032; BRAF inhibitor), binimetinib (MEK-162; MEK inhibitor), everolimus (RAD001; mTOR inhibitor) and triciribidine (API-2; AKT inhibitor)...
May 17, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28504868/recognizing-latinos-range-of-skin-pigment-and-phototypes-to-enhance-skin-cancer-prevention
#13
June K Robinson, Frank J Penedo, Jennifer L Hay, Nina G Jablonski
Latinos in the United States may have the mistaken assumption that their natural pigmentation protects them from developing skin cancer that, effectively, serves as a barrier to Latinos receiving education in primary and secondary prevention of skin cancer. Latino adults of Mexican or Puerto Rican heritage attending community health fairs in the greater Chicago area responded to a culturally informed and sensitive measure for sunburn and tan, which was previously adapted to capture skin irritation with tenderness from the sun occurring in darker skin types (n=350)...
May 15, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28504826/pigmented-macules-in-waardenburg-syndrome-type-2-due-to-kitlg-mutation
#14
LETTER
Yasushi Ogawa, Michihiro Kono, Masashi Akiyama
We report a patient with Waardenburg syndrome (WS) type 2 who had the unusual complication of large pigmented macules. Whole-exome sequencing revealed a previously unreported homozygous KITLG mutation to be the causative gene. KITLG defect is a rare cause of WS, with only one case having been reported previously. Interestingly, both the previously reported case and the present case had large pigmented macules (café-au-lait spots). Importantly, KITLG mutations are causative of another pigmentation disorder, namely familial progressive hyper- and hypopigmentation (FPHH), which may also be accompanied by pigmented macules...
May 15, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28481450/novel-regulation-of-melanogenesis-by-adiponectin-via-the-ampk-crtc-pathway
#15
Seunghyun Bang, Kwang Hee Won, Hye-Rim Moon, Hanju Yoo, Areum Hong, Youngsup Song, Sung Eun Chang
Several studies observed that adiponectin, an important adipokine that improves glucose metabolism by regulating AMP-activated protein kinase (AMPK) signaling, is dermatologically beneficial. In our recent microarray data, we found that adiponectin expression was lower in lesional skin than in non-lesional skin of melasma patients. Given that AMPK is a key adiponectin signaling mediator, we investigated the role of adiponectin and AICAR, a cell-permeable AMPK activator, in melanogenesis. We herein showed that adiponectin and AICAR downregulated MITF, tyrosinase, TRP-1, and DCT expression and reduced melanin content in normal human and mouse melanocytes...
May 8, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28636210/graphical-displays
#16
EDITORIAL
Heinz Arnheiter
No abstract text is available yet for this article.
July 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28397350/no-association-between-prediagnosis-exercise-and-survival-in-patients-with-high-risk-primary-melanoma-a-population-based-study
#17
LETTER
Emily Schwitzer, Irene Orlow, Emily C Zabor, Colin B Begg, Marianne Berwick, Nancy E Thomas, Peter A Kanetsky, Lee W Jones
No abstract text is available yet for this article.
July 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28379638/meeting-report-vitiligo-global-issues-consensus-conference-workshop-outcome-measurement-instruments-and-vitiligo-international-symposium-rome-nov-30-dec-3rd
#18
Nanja van Geel, Katia Boniface, Julien Seneschal, Clément Jacquemin, Reinhart Speeckaert, Albert Wolkerstorfer, Marcel Bekkenk, Janny E Lommerts, Iltefat Hamzavi, Amit Pandya, Viktoria Eleftheriadou, Khaled Ezzedine, Diana Giannarelli, Maria Gnarra, Isabella Sperduti, Cecilia Prinsen, John Harris, Alain Taieb, Mauro Picardo
No abstract text is available yet for this article.
July 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28379630/uv-induced-somatic-mutations-elicit-a-functional-t-cell-response-in-the-yummer1-7-mouse-melanoma-model
#19
Jake Wang, Curtis J Perry, Katrina Meeth, Durga Thakral, William Damsky, Goran Micevic, Susan Kaech, Kim Blenman, Marcus Bosenberg
Human melanomas exhibit relatively high somatic mutation burden compared to other malignancies. These somatic mutations may produce neoantigens that are recognized by the immune system, leading to an antitumor response. By irradiating a parental mouse melanoma cell line carrying three driver mutations with UVB and expanding a single-cell clone, we generated a mutagenized model that exhibits high somatic mutation burden. When inoculated at low cell numbers in immunocompetent C57BL/6J mice, YUMMER1.7 (Yale University Mouse Melanoma Exposed to Radiation) regresses after a brief period of growth...
July 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28379616/from-fish-bowl-to-bedside-the-power-of-zebrafish-to-unravel-melanoma-pathogenesis-and-discover-new-therapeutics
#20
REVIEW
Ellen van Rooijen, Maurizio Fazio, Leonard I Zon
Melanoma is the most aggressive and deadliest form of skin cancer. A detailed knowledge of the cellular, molecular, and genetic events underlying melanoma progression is highly relevant to diagnosis, prognosis and risk stratification, and the development of new therapies. In the last decade, zebrafish have emerged as a valuable model system for the study of melanoma. Pathway conservation, coupled with the availability of robust genetic, transgenic, and chemical tools, has made the zebrafish a powerful model for identifying novel disease genes, visualizing cancer initiation, interrogating tumor-microenvironment interactions, and discovering new therapeutics that regulate melanocyte and melanoma development...
July 2017: Pigment Cell & Melanoma Research
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