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Pigment Cell & Melanoma Research

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https://www.readbyqxmd.com/read/29453787/a-phase-ii-trial-of-riluzole-an-antagonist-of-metabotropic-glutamate-receptor-1-grm1-signaling-in-patients-with-advanced-melanoma
#1
Janice M Mehnert, Ann W Silk, Yu Wen, J H Lee, Liesel Dudek, Byeong-Seon Jeong, Jiadong Li, Jason M Schenkel, Evita Sadimin, Michael Kane, Hongxia Lin, Weichung J Shih, Andrew Zloza, Suzie Chen, James S Goydos
Studies demonstrate that GRM, expressed by >60% of human melanomas, may be a therapeutic target. We performed a phase II trial of 100 mg po bid of riluzole, an inhibitor of GRM1 signaling, in patients with advanced melanoma with the primary endpoint of response rate. Thirteen patients with GRM1-positive tumors were enrolled. No objective responses were observed and accrual was stopped. Stable disease was noted in 6 (46%) patients, with 1 patient on study for 42 weeks. Riluzole was well-tolerated, with fatigue (62%) as the most common adverse event...
February 17, 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29443462/helping-hand-for-melanoma-invasion-transparent-zebrafish-can-catch-macrophages-in-the-act
#2
Nikolay Ogryzko, Yi Feng
Coverage on "Macrophage-Dependent Cytoplasmic Transfer during Melanoma Invasion In Vivo" Development Cell, Roh-Johnson et al., 2017, Developmental Cell 43, 549-562.Metastatic melanoma ranks amongst the deadliest types of cancer and metastasis itself is the primary killer in most solid tumours, yet gaps still exist in our understanding of this process. We know that innate immune cells, particularly tumour associated macrophage, play a significant role in promoting metastasis (Kitamura, Qian, & Pollard, 2015)...
February 14, 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29436173/development-and-validation-of-a-reproducible-model-for-studying-post-inflammatory-hyperpigmentation
#3
LETTER
Thierry Passeron, Stéphanie Nouveau, Christine Duval, Nathalie Cardot-Leccia, Virginie Piffaut, Emilie Bourreau, Catherine Queille-Roussel, Françoise Bernerd
Post-inflammatory hyperpigmentation (PIH) has been reported to be the second most important dermatological diagnosis in the African American population with up to 20% of diagnoses linked to PIH (Alexis et al., 2007). The prevalence of PIH is also high in Hispanic populations ranging from 6 to 7.5% (Sanchez, 2003). Although more frequent in dark-skinned individuals (Davis and Callender, 2010), PIH is not uncommon in fair skin types representing 5.7% of dermatological problems in a population of European ancestry with skin types I to III (Taylor et al...
February 12, 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29419941/toward-the-full-spectrum-of-genes-for-human-skin-colour
#4
Richard A Sturm, David L Duffy
Humans across the globe shows a remarkable diversity in colouration of skin, hair and eyes (Jablonski & Chaplin, 2017) reflecting adaption of pigmentation genes within populations to their environment (Sturm & Duffy, 2012), as well as other evolutionary forces. Skin colour is highly correlated with incident levels of solar UV, and this has led to hypotheses that the need for vitamin D synthesis and protection from photolysis of folate are major balancing selective pressures modulating melanogenesis in the epidermis necessary for both healthy bones at high Northern latitudes experiencing low solar irradiance, but also shielding the skin from the high equatorial sun exposure...
February 8, 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29385656/t-type-calcium-channels-drive-migration-invasion-in-brafv600e-melanoma-cells-through-snail1
#5
O Maiques, C Barceló, A Panosa, J Pijuan, J L Orgaz, I Rodriguez-Hernandez, C Matas-Nadal, G Tell, R Vilella, A Fabra, Puig S, V Sanz-Moreno, X Matias-Guiu, C Canti, J Herreros, R M Marti, A Macià
Melanoma is a malignant tumor derived from melanocytes. Once disseminated, it is usually highly resistant to chemotherapy and is associated with poor prognosis. We have recently reported that T-type calcium channels (TTCCs) are overexpressed in melanoma cells and play an important role in melanoma progression. Importantly, TTCC pharmacological blockers reduce proliferation and deregulate autophagy leading to apoptosis. Here, we analyze the role of autophagy during migration/invasion of melanoma cells. TTCC Cav3...
January 31, 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29350885/unexpected-impact-of-esterification-on-the-antioxidant-activity-and-photo-stability-of-a-eumelanin-from-5-6-dihydroxyindole-2-carboxylic-acid
#6
Raffaella Micillo, Mariagrazia Iacomino, Marco Perfetti, Lucia Panzella, Kenzo Koike, Gerardino D'Errico, Marco d'Ischia, Alessandra Napolitano
To inquire into the role of the carboxyl group as determinant of the properties of 5,6-dihydroxyindole melanins, melanins from aerial oxidation of 5,6-dihydroxyindole (DHICA) and its methyl ester MeDHICA were comparatively tested for their antioxidant activity. MALDI MS spectrometry analysis of MeDHICA melanin provided evidence for a collection of intact oligomers. EPR analysis showed g-values almost identical and signal amplitudes (ΔB) comparable to those of DHICA melanin, but spin density was one order of magnitude higher, with a different response to pH changes...
January 19, 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29345414/molecular-characterization-of-a-series-of-990-index-patients-with-albinism
#7
Eulalie Lasseaux, Claudio Plaisant, Vincent Michaud, Perrine Pennamen, Aurelien Trimouille, Laetitia Gaston, Solène Monfermé, Didier Lacombe, Caroline Rooryck, Fanny Morice-Picard, Benoît Arveiler
Albinism is a clinically and genetically heterogeneous disease characterized by variable degrees of hypopigmentation and by nystagmus, foveal hypoplasia, and chiasmatic misrouting of the optic nerves. The wide phenotypic heterogeneity impedes the establishment of phenotype-genotype correlations. To obtain a precise diagnosis, we screened the 19 known albinism genes in 990 index patients using targeted next-generation sequencing (NGS) and high-resolution comparative genomic hybridization. A molecular diagnosis was obtained in 72...
January 18, 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29337423/the-next-generation-of-melanocyte-data-genetic-epigenetic-and-transcriptional-resource-datasets-and-analysis-tools
#8
Stacie K Loftus
Genomics is a common thread linking all aspects of pigment cell biology, including melanocyte- and melanosome-related functions, pigmentary disorders, normal human pigmentation variation and melanoma. Recently, genomic-scale Next Generation Sequencing (NGS) analyses have rapidly expanded, because of reductions in sequencing costs, increased assay sensitivity, and smaller sample requirement. These NGS technologies have been adapted to assay RNA transcript expression, chromatin accessibility, DNA methylation, histone modifications, and transcription factor binding...
January 16, 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29316274/comparison-of-xiphophorus-and-human-melanoma-transcriptomes-reveals-conserved-pathway-interactions
#9
Yuan Lu, Mikki Boswell, William Boswell, Susanne Kneitz, Michael Hausmann, Barbara Klotz, Janine Regneri, Markita Savage, Angel Amores, John Postlethwait, Wesley Warren, Manfred Schartl, Ronald Walter
Comparative analysis of human and animal model melanomas can uncover conserved pathways and genetic changes that are relevant for the biology of cancer cells. Spontaneous melanoma in Xiphophorus interspecies backcross hybrid progeny may be informative in identifying genes and functional pathways that are similarly related to melanoma development in all vertebrates, including humans. To assess functional pathways involved in the Xiphophorus melanoma, we performed gene expression profiling of the melanomas produced in interspecies BC1 and successive backcross generations (i...
January 8, 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29316280/giant-congenital-melanocytic-nevus-with-vascular-malformation-and-epidermal-cysts-associated-with-a-somatic-activating-mutation-in-braf
#10
Heather C Etchevers, Christian Rose, Birgit Kahle, Helmuth Vorbringer, Frédéric Fina, Pauline Heux, Irina Berger, Benjamin Schwarz, Stéphane Zaffran, Nicolas Macagno, Sven Krengel
Giant congenital melanocytic nevi may be symptomatically isolated, or syndromic. Associations with capillary malformations are exceptional, and development of epidermal cysts has not been described. A 71-year old patient with a giant congenital melanocytic nevus of the lower back, buttocks and thighs was asymptomatic except for unexpected hemorrhage during partial surgical excision years before. Blunt trauma at age 64 initiated recurrent, severe pain under the nevus; multiple large epidermal cysts then developed within it...
January 5, 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29288529/mapk-pathway-inhibitors-rescue-lethal-phenotypes-in-a-braf-gain-of-function-drosophila-melanogaster-model
#11
LETTER
Anna Volkhardt, Jens Bohnekamp, Isabelle Pfeifle, Christoph Engel, Thomas M Magin, Manfred Kunz
Mutant BRAF is the leading oncogene in melanoma and is found in close to 50% of all melanoma patients (Cancer_Genome_Atlas_Network, 2015). The oncogenic capacity of the BRAFV600E mutation has also been demonstrated in a murine melanoma model (Dankort et al., 2009). This mutation causes the activation of the mitogen-activated protein kinase (MAPK) pathway, which involves BRAF kinase and downstream mitogen-activated extracellular signal-regulated kinases 1/2 (MEK1/2) and extracellular signal-regulated kinases 1/2 (ERK1/2)...
December 30, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29285880/melasma-a-photoaging-disorder
#12
REVIEW
Thierry Passeron, Mauro Picardo
Melasma is a common hyperpigmentary disorder. The impact on the quality of life of affected individuals is well demonstrated, demanding new therapeutic strategies. However, the treatment of melasma remains highly challenging. Melasma is often considered as the main consequence of female hormone stimulation on a predisposed genetic background. Although these two factors do contribute to this acquired pigmentary disorder, the last decade has revealed several other key players and brought new pieces to the complex puzzle of the pathophysiology of melasma...
December 29, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29277979/survival-and-prognostic-factors-for-patients-with-melanoma-brain-metastases-in-the-era-of-modern-systemic-therapy
#13
Martin Tio, Xuan Wang, Matteo S Carlino, Brindha Shivalingam, Gerald B Fogarty, Alexander D Guminski, Serigne Lo, Angela M Hong, Alexander M Menzies, Georgina V Long
Historically, the prognosis of patients with melanoma brain metastases is poor, with median overall survival (OS) of 4-6 months. Little is known of OS in the era of modern systemic therapies and local therapy with stereotactic radiosurgery (SRS) or surgery. Patients diagnosed with melanoma brain metastases at Melanoma Institute Australia from January 2011 to December 2014 were included. OS and prognostic factors were analysed using Cox regression and Kaplan-Meier survival analyses.355 patients were included...
December 26, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29272074/prevalence-of-vitiligo-in-brazil-a-population-survey
#14
LETTER
Caio Cesar Silva de Castro, Hélio Amante Miot
population data concerning the prevalence of vitiligo are variable according to age, ethnic groups and study methodology. It varies in adults from 0.1-2.0%, however, a meta-analysis has suggested publication bias and indicated a more conservative estimation of 0.2%.(Zhang et al., 2016). Vitiligo affects both genders with a slight female predilection, and the disease onset occurs mostly at adulthood (2nd -3rd decades). This article is protected by copyright. All rights reserved.
December 22, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29266793/rapid-melanoma-induction-in-mice-expressing-oncogenic-brafv600e-using-mitf-cre
#15
LETTER
Oscar Urtatiz, Atefeh M V Samani, Janel L Kopp, Catherine D Van Raamsdonk
No abstract text is available yet for this article.
December 20, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29239123/seeing-the-light-to-change-colour-an-evolutionary-perspective-on-the-role-of-melanopsin-in-neuroendocrine-circuits-regulating-light-mediated-skin-pigmentation
#16
REVIEW
Gabriel E Bertolesi, Sarah McFarlane
Melanopsin photopigments, Opn4x and Opn4m, were evolutionary selected to "see the light" in systems that regulate skin colour change. In this review, we analyse the roles of melanopsins, and how critical evolutionary developments, including the requirement for thermoregulation and ultraviolet protection, the emergence of a background adaptation mechanism in land-dwelling amphibian ancestors and the loss of a photosensitive pineal gland in mammals, may have helped sculpt the mechanisms that regulate light-controlled skin pigmentation...
December 14, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29224244/a-histopathological-classification-system-of-tyr-nrasq61k-murine-melanocytic-lesions-a-reproducible-simplified-classification
#17
Pierre Sohier, Léa Legrand, Zackie Aktary, Christine Grill, Véronique Delmas, Florence Bernex, Edouard Reyes-Gomez, Lionel Larue, Béatrice Vergier
Genetically engineered mouse models offer essential opportunities to investigate the mechanisms of initiation and progression in melanoma. Here we report a new simplified histopathology classification of mouse melanocytic lesions in Tyr::NRASQ61K derived models, using an interactive decision tree that produces homogeneous categories. Reproducibility for this classification system was evaluated on a panel of representative cases of murine melanocytic lesions by pathologists and basic scientists. Reproducibility, measured as inter-rater agreement between evaluators using a modified Fleiss' kappa statistic revealed a very good agreement between observers...
December 10, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29274135/2018-forward-going-online-and-all-that
#18
EDITORIAL
Vijayasaradhi Setaluri
No abstract text is available yet for this article.
January 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29171936/braf-internal-deletions-and-resistance-to-braf-mek-inhibitor-therapy
#19
Douglas B Johnson, Merrida A Childress, Zachary R Chalmers, Garrett M Frampton, Siraj M Ali, Samuel M Rubinstein, David Fabrizio, Jeffrey S Ross, Sohail Balasubramanian, Vincent A Miller, Philip J Stephens, Jeffrey A Sosman, Christine M Lovly
BRAF and MEK inhibitors have improved clinical outcomes in advanced, BRAFV600 - mutated melanomas. Acquired resistance occurs in most patients, with numerous and diverse drivers. We obtained pre-treatment and progression biopsies from a patient who progressed on dabrafenib and trametinib. In addition to a preserved BRAFV600E mutation, an internal deletion (rearrangement) of BRAF was observed in the progression sample. This deletion involved exons 2-8, which includes the Ras-binding domain, and is analogous to previously documented BRAF fusions and splice variants known to reactivate RAS-RAF-MEK-ERK signaling...
November 24, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29171182/acid-hydrolysis-reveals-a-low-but-constant-level-of-pheomelanin-in-human-black-to-brown-hair
#20
Shosuke Ito, Shiho Miyake, Shoji Maruyama, Itaru Suzuki, Stéphane Commo, Yukiko Nakanishi, Kazumasa Wakamatsu
We previously reported a constant ratio of the benzothiazole-pheomelanin marker thiazole-2,4,5-tricarboxylic acid (TTCA) to the eumelanin marker pyrrole-2,3,5-tricaboxylic acid (PTCA) in eumelanic, black human hair. A constant level (20-25%) of benzothiazole-type pheomelanin was recently demonstrated in human skin with varying concentrations of melanin. Therefore, in this study, we aimed to investigate the origin of pheomelanin markers in black to brown human hair by developing a method to remove protein components from hair by heating with 6 M HCl at 110°C for 16 h...
November 24, 2017: Pigment Cell & Melanoma Research
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