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Journal of Crohn's & Colitis

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https://www.readbyqxmd.com/read/29420705/differential-expression-of-micrornas-in-peripheral-blood-mononuclear-cells-identifies-autophagy-and-tgf-beta-related-signatures-aberrantly-expressed-in-inflammatory-bowel-disease
#1
Aylia Mohammadi, Orlaith B Kelly, Melissa Filice, Boyko Kabakchiev, Michelle I Smith, Mark S Silverberg
Background and Aims: MicroRNAs (miRNAs) have emerged as important regulators in inflammatory bowel disease (IBD). This study investigated differential expression of miRNAs across clinical phenotypes in a well-characterized cohort of IBD patients and healthy controls (HCs). Methods: A cohort with Crohn's disease (CD), ulcerative colitis (UC), and HC was prospectively accrued. Total RNA was extracted from peripheral blood mononuclear cells for all subjects. MiRNA expression was measured using NanoString Technologies...
February 6, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29415206/does-familial-ibd-have-its-own-signature
#2
Che-Yung Chao, Talat Bessissow
No abstract text is available yet for this article.
February 5, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29415186/microbial-spectrum-of-intra-abdominal-abscesses-in-perforating-crohn-s-disease-results-from-a-prospective-german-registry
#3
P A Reuken, W Kruis, C Maaser, N Teich, J Büning, J C Preiß, R Schmelz, T Bruns, S Fichtner-Feigl, A Stallmach
Background: Intra-abdominal abscesses (IAA) are common life threatening complications in patients with Crohn's disease (CD). In addition to interventional drainage and surgical therapy, empirical antibiotic therapy represents a corner stone of treatment but contemporary data on microbial spectra and antimicrobial resistance are scarce. Methods: We recruited 105 patients with CD and IAA from 9 German centers for a prospective registry in order to characterize the microbiological spectrum, resistance profiles, antibiotic therapy and outcome...
February 5, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29415255/validation-of-the-united-registries-for-clinical-assessment-and-research-ur-care-a-european-online-registry-for-clinical-care-and-research-in-inflammatory-bowel-disease
#4
Johan Burisch, Javier P Gisbert, Britta Siegmund, Dominik Bettenworth, Sandra Bohn Thomsen, Isabelle Cleynen, Anneline Cremer, Nik John Sheng Ding, Federica Furfaro, Michail Galanopoulos, Philip Christian Grunert, Jurij Hanzel, Tamara Knezevic Ivanovski, Eduards Krustins, Nurulamin Noor, Neil O'Morain, Iago Rodríguez-Lago, Michael Scharl, Julia Tua, Mathieu Uzzan, Nuha Ali Yassin, Filip Baert, Ebbe Langholz
Background: The "United Registries for Clinical Assessment and Research" (UR-CARE) database is an initiative of the European Crohn's and Colitis Organisation (ECCO) to facilitate daily patient care and research studies in inflammatory bowel disease (IBD). Herein, we sought to validate the database by using fictional case histories of patients with IBD that were to be entered by observers of varying experience in IBD. Methods: A total of 19 observers entered 5 patient case histories into the database...
February 3, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29401297/long-term-outcome-of-early-combined-immunosuppression-versus-conventional-management-in-newly-diagnosed-crohn-s-disease
#5
Daniël R Hoekman, Judith A Stibbe, Filip J Baert, Philip Caenepeel, Philippe Vergauwe, Martine De Vos, Daniel W Hommes, Marc A Benninga, Severine A Vermeire, Geert R D'Haens
Background and Aims: Long term outcomes of early combined immunosuppression (top-down) compared to conventional management (step-up) in recently diagnosed Crohn's disease (CD) are unknown. We aimed to investigate long-term outcomes of participants of the Step-up/Top-down-trial. Methods: Trial participants' medical records were reviewed retrospectively. For 16 semesters following the 2-year trial, we recorded: clinical activity, medication use, flares, hospitalization, surgery and fistulas...
February 1, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29401250/how-a-bite-on-the-cheek-of-a-29-year-old-female-patient-with-crohn-s-disease-turned-out-to-be-tuberculosis
#6
Henning Trawinski, Niels Teich, Christoph Lübbert
No abstract text is available yet for this article.
February 1, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29390096/the-importance-of-detecting-irritable-bowel-like-symptoms-in-ibd-patients
#7
Petra Weimers, Johan Burisch
No abstract text is available yet for this article.
January 30, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29385425/corrigendum-exposure-efficacy-relationships-for-vedolizumab-induction-therapy-in-patients-with-ulcerative-colitis-or-crohn-s-disease
#8
Maria Rosario, Jonathan L French, Nathanael L Dirks, Serap Sankoh, Asit Parikh, Huyuan Yang, Silvio Danese, Jean-Frédéric Colombel, Michael Smyth, William J Sandborn, Brian G Feagan, Walter Reinisch, Bruce E Sands, Miguel Sans, Irving Fox
No abstract text is available yet for this article.
January 29, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29385469/anti-tnf-therapeutic-drug-monitoring-in-post-operative-crohn-s-disease
#9
Emily K Wright, Michael A Kamm, Peter De Cruz, Amy L Hamilton, Fabiyola Selvaraj, Fred Princen, Alexandra Gorelik, Danny Liew, Lani Prideaux, Ian C Lawrance, Jane M Andrews, Peter A Bampton, Simon L Jakobovits, Timothy H Florin, Peter R Gibson, Henry Debinski, Finlay A Macrae, Douglas Samuel, Ian Kronborg, Graham Radford-Smith, Richard B Gearry, Warwick Selby, Sally J Bell, Steven J Brown, William R Connell
Background: Anti-TNF prevents post-operative Crohn's disease recurrence in most patients but not all. This study aimed to define the relationship between adalimumab pharmacokinetics, maintenance of remission and recurrence. Methods: As part of a study of post-operative Crohn's disease management, some patients undergoing resection received prophylactic post-operative adalimumab. In these patients, serum and faecal adalimumab concentration and serum anti-adalimumab antibodies (AAA) were measured at 6, 12 and 18 months post-operatively...
January 27, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29385430/the-effect-of-low-dose-naltrexone-on-medication-in-inflammatory-bowel-disease-a-quasi-experimental-before-and-after-prescription-database-study
#10
Guttorm Raknes, Pia Simonsen, Lars Småbrekke
Background and Aims: Low dose naltrexone (LDN) is a controversial off-label treatment used by many Crohn's disease (CD) and ulcerative colitis (UC) patients. A small number of preliminary studies indicate that LDN might be beneficial in CD, but evidence is too scarce to demonstrate efficacy. We wanted to examine whether initiation of LDN therapy by patients with inflammatory bowel disease (IBD) was followed by changes in dispensing of relevant medication. Methods: We performed a quasi-experimental before and after study following a sudden increase of LDN use in the Norwegian population in 2013...
January 27, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29385427/diagnostic-yield-of-dysplasia-in-polyp-adjacent-biopsies-for-patients-with-inflammatory-bowel-disease-a-cross-sectional-study
#11
Conor Lahiff, Lai Mun Wang, Simon P L Travis, James E East
Introduction: Patients with inflammatory bowel disease (IBD) undergoing polypectomy are recommended by current guidelines to have biopsies taken from adjacent mucosa to determine whether there is dysplasia present. With improvements in endoscopic imaging it is now possible to characterise colonic lesions with higher levels of confidence than previously. We reviewed the diagnostic yield of polyp-adjacent biopsies in IBD. Materials and Methods: A systematic search of our histopathology database revealed cases where polyps had been endoscopically resected or biopsied in patients with IBD...
January 27, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29377986/balloon-dilation-of-intrinsic-small-bowel-strictures-still-doubts-about-its-efficacy
#12
Talat Bessissow, Gert Van Assche
No abstract text is available yet for this article.
January 25, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29370397/primary-non-response-to-tumor-necrosis-factor-antagonists-is-associated-with-inferior-response-to-second-line-biologics-in-patients-with-inflammatory-bowel-diseases-a-systematic-review-and-meta-analysis
#13
Siddharth Singh, John George, Brigid S Boland, Niels Vande Casteele, William J Sandborn
Background and Aims: We sought to analyze whether response to second-line biologic varies depending on reason for discontinuation of primary anti-TNF agent (primary non-response [PNR], secondary loss of response [LOR] after initial response, or intolerance), through a systematic review and meta-analysis. Methods: Through a systematic search through May 31, 2017, we identified 8 randomized controlled trials (RCTs) of biologics in patients with IBD with prior exposure to anti-TNF agents, that stratified response to second-line therapy by reason for discontinuing primary anti-TNF therapy (PNR vs...
January 23, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29370359/smoking-is-associated-with-an-increased-risk-of-microscopic-colitis-results-from-two-large-prospective-cohort-studies-of-us-women
#14
Kristin E Burke, Ashwin N Ananthakrishnan, Paul Lochhead, Ola Olen, Jonas F Ludvigsson, James M Richter, Andrew T Chan, Hamed Khalili
Introduction: Long-term data on the influence of smoking on risk of microscopic colitis are limited. We therefore sought to examine and characterize the association between smoking and risk of incident microscopic colitis in two large prospective cohorts of women. Methods: We conducted a prospective study of 231,015 women enrolled in the Nurses' Health Study (NHS) and NHSII. Information regarding smoking, other lifestyle factors, and medications were collected biennially from 1976 to 2012 in NHS and 1989 to 2013 in NHSII...
January 23, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29370346/reduced-risk-of-inflammatory-bowel-disease-associated-colorectal-neoplasia-with-use-of-thiopurines-a-systematic-review-and-meta-analysis
#15
Zhehui Zhu, Zubing Mei, Yuegui Guo, Guanghui Wang, Tingyu Wu, Ximao Cui, Zhenyu Huang, Yilian Zhu, Dongpeng Wen, Jinlve Song, Hailan He, Weimin Xu, Long Cui, Chenying Liu
Background & Aims: The association between thiopurines and colorectal neoplasia risk remains controversial in inflammatory bowel disease (IBD) patients. We performed a systematic review and meta-analysis examining this association. Methods: A comprehensive search of the PubMed, EMBASE and Cochrane Library databases was performed to identify relevant literature. Random-effects models were applied to calculate the pooled odds ratio (OR) and relative risk (RR) with corresponding 95% confidence intervals (CIs) among case-control and cohort studies, respectively...
January 23, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29361163/genomic-and-expression-analyses-identify-a-disease-modifying-variant-for-fibrostenotic-crohn-s-disease
#16
Marijn C Visschedijk, Lieke M Spekhorst, Shih-Chin Cheng, Ellen S van Loo, B H Dianne Jansen, Tjasso Blokzijl, Hyunsuk Kil, Dirk J de Jong, Marieke Pierik, Jeroen P W J Maljaars, C Janneke van der Woude, Adriaan A van Bodegraven, Bas Oldenburg, Mark Löwenberg, Vincent B Nieuwenhuijs, Floris Imhann, Suzanne van Sommeren, Rudi Alberts, Ramnik J Xavier, Gerard Dijkstra, Klaas Nico Faber, C Marcelo Aldaz, Rinse K Weersma, Eleonora A M Festen
Background and Aims: Crohn's Disease (CD) is a chronic inflammatory disease with unpredictable behaviour. More than half of CD patients eventually develop complications such as stenosis, for which they then require endoscopic dilatation or surgery, as no anti-fibrotic drugs are currently available. We aim to identify disease-modifying genes associated with fibrostenotic CD. Methods: We performed a within-case analysis comparing "extreme phenotypes" using the Immunochip and replication of the top SNPs with Agena Bioscience in two independent case-control cohorts totalling 322 cases with fibrostenotis (recurrent after surgery) and 619 cases with purely inflammatory CD...
January 19, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29360962/low-doses-of-azathioprine-are-effective-in-combination-with-infliximab-in-ibd-but-may-be-not-during-the-induction-therapy
#17
Xavier Roblin, B Flourié, Stephane Paul
No abstract text is available yet for this article.
January 19, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29325112/autologous-haematopoietic-stem-cell-transplantation-ahsct-in-severe-crohn-s-disease-a-review-on-behalf-of-ecco-and-ebmt
#18
John A Snowden, Julián Panés, Tobias Alexander, Matthieu Allez, Sandro Ardizzone, Daan Dierickx, Jürgen Finke, Peter Hasselblatt, Chris Hawkey, Majid Kazmi, James O Lindsay, Francesco Onida, Azucena Salas, Riccardo Saccardi, Severine Vermeire, Montserrat Rovira, Elena Ricart
Despite the major recent progress in the treatment of Crohn's disease (CD), there is a subset of patients in whom the disease runs an aggressive course with progressive tissue damage requiring early and repeated surgical management. Increasing evidence supports sustained and profound improvement in gastrointestinal parameters and quality of life following high dose immunosuppressive therapy and autologous haematopoietic stem cell transplantation (AHSCT) compared to standard therapy in this context. In addition, international transplant registry data reflects the use of AHSCT in CD outside of trials in selected patients...
January 8, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29309546/inclusion-of-the-mesentery-in-ileocolic-resection-for-crohn-s-disease-is-associated-with-reduced-surgical-recurrence
#19
J Calvin Coffey, Miranda G Kiernan, Shaheel M Sahebally, Awad Jarrar, John P Burke, Patrick A Kiely, Bo Shen, David Waldron, Colin Peirce, Manus Moloney, Maeve Skelly, Paul Tibbitts, Hena Hidayat, Peter N Faul, Vourneen Healy, D Peter O Leary, Leon G Walsh, Peter Dockery, P Ronan O Connell, Sean Martin, Fergus Shanahan, Claudio Fiocchi, Colum Dunne
Background and Aims: Inclusion of the mesentery during resection for colorectal cancer is associated with improved outcomes but has yet to be evaluated in Crohn's disease. This study aimed to determine the rate of surgical recurrence after inclusion of mesentery during ileocolic resection for Crohn's disease. Methods: Surgical recurrence rates were compared between two cohorts. Cohort A (n=30) underwent conventional ileocolic resection where the mesentery was divided flush with the intestine...
January 4, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29304229/cd16-macrophages-mediate-fibrosis-in-inflammatory-bowel-disease
#20
Pedro Salvador, Dulce Carolina Macías-Ceja, Laura Gisbert-Ferrándiz, Carlos Hernández, David Bernardo, Rafael Alós, Francisco Navarro-Vicente, Juan Vicente Esplugues, Dolores Ortiz-Masiá, Maria Dolores Barrachina, Sara Calatayud
Background and aims: Fibrosis is a common complication of Crohn's disease, and is related with dysregulated tissular repair following inflammation, in which macrophages play a central role. We have previously observed that STAT6-/- mice present delayed mucosal recovery after TNBS-induced colitis due to a deficiency in reparatory IL4/STAT6-dependent M2 macrophages, which can be reverted by the exogenous transfer of this cell type. In the present study we aimed to analyze the role of STAT6-dependent macrophages in intestinal fibrosis...
January 3, 2018: Journal of Crohn's & Colitis
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