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Journal of Crohn's & Colitis

Jessica R de Bruyn, Gijs R van den Brink, Jessica Steenkamer, Christianne J Buskens, Willem A Bemelman, Sander Meisner, Vanesa Muncan, Anje A Te Velde, Geert R D'Haens, Manon E Wildenberg
Background and Aims: Crohn's disease is a chronic inflammatory disorder of the intestine and often leads to fibrosis, characterized by excess extracellular matrix [ECM] deposition, increased tissue stiffness, and stricture formation. Here we evaluated the contribution of myofibroblast-ECM interactions to the development of intestinal fibrosis in Crohn's disease. Methods: Matched primary human myofibroblasts were isolated from stenotic, inflamed and normal-appearing small intestine within the same Crohn's disease patient [n = 10]...
April 16, 2018: Journal of Crohn's & Colitis
Åsa V Keita, Mårten Carl Lindqvist, Åke Öst, Carlos D L Magana, Ida Schoultz, Jonas Halfvarson
Background and aims: The aetiology of Crohn's disease is poorly understood. By investigating twin pairs discordant for Crohn's disease we aimed to assess if the dysregulated barrier represents a cause or a consequence of inflammation and to evaluate the impact of genetic predisposition on barrier function. Methods: Ileal biopsies from 15 twin pairs discordant for Crohn's disease (monozygotic n=9, dizygotic n=6) and 10 external controls were mounted in Ussing chambers to assess paracellular permeability to51Chromium (Cr)-EDTA and trancellular passage to non-pathogenic E...
April 12, 2018: Journal of Crohn's & Colitis
Dion S J Wintjens, Roel M M Bogie, Tim R A van den Heuvel, Chantal M C le Clercq, Liekele E Oostenbrug, Mariëlle J L Romberg-Camps, Jan-Willem Straathof, Laurents P S Stassen, Ad A M Masclee, Daisy M A E Jonkers, Silvia Sanduleanu-Dascalescu, Marie J Pierik
Background and Aims: Patients with inflammatory bowel disease (IBD) colitis are at increased risk for colorectal cancer (CRC). We examined the proportion and most likely aetiology of potentially preventable postcolonoscopy CRCs (PCCRCs) in a population-based cohort. Furthermore, adherence to IBD surveillance guidelines was evaluated in both PCCRCs and the remainder of prevalent CRCs. Methods: All IBD patients diagnosed from 1991 to 2011 in the South Limburg region of The Netherlands (i...
April 10, 2018: Journal of Crohn's & Colitis
Zhujun Wang, Wenyan Zhang, Chengxin Luo, Min Zhu, Yu Zhen, Jingxi Mu, Yan Zhang, Renwei Hu, Yufang Wang, Zhonghui Wen, Qin Ouyang, Shuyuan Xiao, Hu Zhang
Background and Aims: Primary intestinal Epstein-Barr virus (EBV)-associated natural killer/T-cell lymphoproliferative disorder (PIEBV+ NK/T-LPD) is a rare clinical entity, which is difficult to differentiate from inflammatory bowel disease (IBD). We present a series of Chinese patients with PIEBV+ NK/T-LPD to increase awareness of this condition among clinicians. Methods: Patients diagnosed with PIEBV+ NK/T-LPD at West China hospital between 2014 and 2016 were included...
April 7, 2018: Journal of Crohn's & Colitis
David Kevans, Sanjay Murthy, Diane R Mould, Mark S Silverberg
Background and Aims: A significant proportion of patients with corticosteroid-refractory acute ulcerative colitis [UC] fail therapy. We aimed to assess the pharmacokinetics [PK] of infliximab [IFX] in patients with corticosteroid-refractory acute UC and determine the association between induction IFX PK and short- and long-term therapy outcome. Methods: A population PK model was developed using data from 51 patients with UC [n = 42] and Crohn's disease [n = 9]. A subset of patients [n = 36] with acute corticosteroid-refractory UC (median Mayo score 11 [range 8-12]; 33 of 36 hospitalized; median corticosteroid dose at study entry 50mg prednisolone equivalent IV/oral) commencing IFX were studied to assess further correlations between PK from the first induction dose and therapy outcomes...
April 6, 2018: Journal of Crohn's & Colitis
Jack Peter, Jonas Zeitz, Andreas Stallmach
No abstract text is available yet for this article.
April 5, 2018: Journal of Crohn's & Colitis
Richard Anthony Wardle, Gita Thapaliya, Adam Nowak, Shellie Radford, Michelle Dalton, Graham Finlayson, Gordon W Moran
Background: Crohn's disease (CD) patients suffer from nutritional deficiencies when in active disease. We aim to examine calorific intake, macronutrient choice and disordered eating behaviour in patients with active CD. Methods: CD patients with matched healthy volunteers (HV) were recruited. Active disease was defined by faecal calprotectin >250ug/g, C-reactive protein >5mg/dl, or active disease seen on endoscopy or imaging. Symptoms were quantified by Harvey-Bradshaw Index (HBI)...
April 3, 2018: Journal of Crohn's & Colitis
Levente Parragi, N Fournier, Jonas Zeitz, Michael Scharl, Thomas Greuter, Philipp Schreiner, Benjamin Misselwitz, Ekaterina Safroneeva, A M Schoepfer, Stephan R Vavricka, Gerhard Rogler, Luc Biedermann
Objectives: Previous population-based studies in patients with ulcerative colitis (UC) revealed variable colectomy rates and colectomy-associated risk factors. Over the last two decades, a decrease in colectomy rates was observed. We assessed risk factors and colectomy rates over time in UC in the Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS). Methods: Prospectively-collected SIBDCS data, including disease history, baseline characteristics at enrollment, and course of disease, were retrospectively analyzed...
March 31, 2018: Journal of Crohn's & Colitis
Daniel G W Johnston, Michelle A Williams, Christoph A Thaiss, Raul Cabrera-Rubio, Mathilde Raverdeau, Craig McEntee, Paul D Cotter, Eran Elinav, Luke A J O'Neill, Sinéad C Corr
Background and aims: microRNAs regulate gene expression and influence the pathogenesis of human diseases. The present study investigated miR-21 in the pathogenesis of intestinal inflammation, as miR-21 is highly expressed in Inflammatory Bowel Disease (IBD). IBD is associated with intestinal barrier dysfunction and an altered gut microbiota. Recent studies have demonstrated that host microRNAs can shape the microbiota. Thus, we determined the influence of miR-21 on the gut microbiota and subsequent impact in a dextran sodium sulphate (DSS)-induced colitis model...
March 28, 2018: Journal of Crohn's & Colitis
Pim J Koelink, Manon E Wildenberg, Larry W Stitt, Brian G Feagan, Martin Koldijk, Angélique B van 't Wout, Raja Atreya, Michael Vieth, Johannan F Brandse, Suzanne Duijst, Anje A Te Velde, Geert R A M D'Haens, Barrett G Levesque, Gijs R van den Brink
Background and Aims: Although several endoscopic and histopathologic indices are available to evaluate severity of inflammation in mouse models of colitis, the reliability of these scoring instruments is unknown. Our aim was to evaluate the reliability of the individual items in the existing indices and develop new scoring systems by selection of the most reliable index items. Methods: Two observers scored the histological slides (n=224) and endoscopy videos (n=201) from treated and untreated Interleukin(IL)-10 knock-out and T-cell transferred SCID mice...
March 28, 2018: Journal of Crohn's & Colitis
Konstantinos Papamichael, Ravy K Vajravelu, Byron P Vaughn, Mark T Osterman, Adam S Cheifetz
Background and aims: Reactive testing has emerged as the new standard of care for managing loss of response to infliximab in inflammatory bowel disease (IBD). Recent data suggest that proactive infliximab monitoring is associated with better therapeutic outcomes in IBD. Nevertheless, there are no data regarding the clinical utility of proactive infliximab monitoring after first reactive testing. We aimed to evaluate long-term outcomes of proactive infliximab monitoring following reactive testing compared to reactive testing alone in patients with IBD...
March 24, 2018: Journal of Crohn's & Colitis
Myunghee Hong, Byong Duk Ye, Suk-Kyun Yang, Seulgi Jung, Ho-Su Lee, Byoung Mok Kim, Soo Bin Lee, Jeonghoon Hong, Jiwon Baek, Sang Hyoung Park, Buhm Han, Yi Li, Wenting Liu, Talin Haritunians, Kent D Taylor, Jerome I Rotter, So-Young Bang, Tae-Hwan Kim, Dermot P B McGovern, Jianjun Liu, Kyuyoung Song
Background and Aims: Recent meta-analysis of genome-wide association studies have identified over 241 inflammatory bowel disease susceptibility loci. However, the known variants only account for a fraction of inflammatory bowel disease heritability. To identify additional susceptibility loci, we performed a trans-ethnic meta-analysis as well as an Asian-specific meta-analysis using all published Immunochip association results of inflammatory bowel disease. Methods: An inverse-variance fixed-effects meta-analysis was carried out across Korean and East Asian Immunochip datasets of 4,156 cases and 4,904 controls (Asian ancestry)...
March 23, 2018: Journal of Crohn's & Colitis
Oren Ledder, Amit Assa, Arie Levine, Johanna C Escher, Lissy de Ridder, Frank Ruemmele, Neil Shah, Ron Shaoul, Victorien M Wolters, Astor Rodrigues, Holm H Uhlig, Carsten Posovszky, Kaija-Leena Kolho, Christian Jakobsen, Shlomi Cohen, Dror S Shouval, Tim de Meij, Javier Martin-de-Carpi, Lisa Richmond, Jiri Bronsky, Mira Friedman, Dan Turner
No abstract text is available yet for this article.
March 17, 2018: Journal of Crohn's & Colitis
Vipul Jairath, Barrett G Levesque, Niels Vande Casteele, Reena Khanna, Mahmoud Mosli, Pieter Hindryckx, Simon Travis, Marjolijn Duijvestein, Jordi Rimola, Julian Panes, Geert D'Haens, William J Sandborn, Brian G Feagan
No abstract text is available yet for this article.
March 16, 2018: Journal of Crohn's & Colitis
R K Boyapati, G T Ho, J Satsangi
No abstract text is available yet for this article.
March 14, 2018: Journal of Crohn's & Colitis
Ji-Eun Kang, Hyun-Do Kim, Soo-Young Park, Jae-Gu Pan, Jeong Hyun Kim, Do-Young Yum
Background and Aims: Commercial superoxide dismutase (SOD) is derived from melon extract and has a potential as a dietary supplement due to its beneficial anti-oxidative effects. We aimed to improve the productivity of SOD compared with plant SOD by using a generally-regarded-as-safe (GRAS) microorganism, Bacillus amyloliquefaciens, and assess its anti-oxidative effect using γ-radiation- and dextransulfate sodium (DSS)-induced oxidative models in mice. Methods: We identified the sodA gene encoding manganese-containing SODs (Mn-SOD) in B...
March 14, 2018: Journal of Crohn's & Colitis
Sangmin Lee, Amy Metcalfe, Maitreyi Raman, Yvette Leung, Fariba Aghajafari, Nicole Letourneau, Remo Panaccione, Gilaad G Kaplan, Cynthia H Seow
Background and Aims: Vitamin D insufficiency is prevalent in individuals with inflammatory bowel disease, as well as in pregnant women; however, the prevalence of vitamin D insufficiency in pregnant women with IBD is unknown. This study assessed the prevalence of vitamin D insufficiency in pregnant women with IBD and the adequacy of recommended supplementation. Methods: A cross-sectional study was conducted in pregnant women with inflammatory bowel disease (Crohn's disease=61, ulcerative colitis=41) and without inflammatory bowel disease (n=574)...
March 13, 2018: Journal of Crohn's & Colitis
Stanislav Sitkin, Timur Vakhitov, Juris Pokrotnieks
No abstract text is available yet for this article.
March 8, 2018: Journal of Crohn's & Colitis
Tuo Chen, Qun Zhou, Dan Zhang, Feng Jiang, Jing Wu, Jin-Yong Zhou, Xiao Zheng, Yu-Gen Chen
Background: Evidence concerning the effect of faecal microbiota transplantation (FMT) in Clostridium difficile infection (CDI) patients with inflammatory bowel disease (IBD) has not been firmly established. Therefore, we performed a systematic review and meta-analysis to evaluate FMT treatment outcomes in patients with IBD treated for CDI. Methods: An electronic search of four databases was conducted until November 1st, 2017. Cohort studies of FMT efficacy and safety in CDI patients with IBD were included...
March 8, 2018: Journal of Crohn's & Colitis
Antonio Rispo, Nicola Imperatore, Anna Testa, Luigi Bucci, Gaetano Luglio, Giovanni Domenico De Palma, Matilde Rea, Olga Maria Nardone, Nicola Caporaso, Fabiana Castiglione
Background: In the management of Crohn's Disease (CD) patients, having a simple score combining clinical, endoscopic and imaging features to predict the risk of surgery could help to tailor treatment more effectively. AIMS: to prospectively evaluate the one-year risk factors for surgery in refractory/severe CD and to generate a risk matrix for predicting the probability of surgery at one year. Methods: CD patients needing a disease re-assessment at our tertiary IBD centre underwent clinical, laboratory, endoscopy and bowel sonography (BS) examinations within one week...
March 8, 2018: Journal of Crohn's & Colitis
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