journal
MENU ▼
Read by QxMD icon Read
search

Journal of Crohn's & Colitis

journal
https://www.readbyqxmd.com/read/29220430/postoperative-outcomes-in-ustekinumab-treated-patients-undergoing-abdominal-operations-for-crohn-s-disease
#1
Amy L Lightner, Nicholas P McKenna, Chung Sang Tse, Neil Hyman, Radhika Smith, Gayane Ovsepyan, Phillip Fleshner, Kristen Crowell, Walter Koltun, Marc Ferrante, Andre D'Hoore, Nathalie Lauwers, Bram Verstockt, Antonino Spinelli, Francesca DiCandido, Laura E Raffals, Kellie L Mathis, Edward V Loftus
Introduction: Ustekinumab, a monoclonal antibody targeting interleukins-12 and -23 is used to treat adults with Crohn's disease (CD). We determined the 30-day postoperative infectious complication rate among CD patients who received ustekinumab within 12 weeks prior to an abdominal operation as compared to patients who received anti-tumor necrosis factor (TNF) agents. Methods: A retrospective chart review of adults with CD who underwent an abdominal operation between 1/1/2015 and 5/1/2017 was performed across six sites...
December 6, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29220429/combination-therapy-with-adalimumab-and-thiopurines-in-inflammatory-bowel-disease-is-it-a-case-of-nepotism-in-pharmacology
#2
Turki AlAmeel, Mahmoud H Mosli
No abstract text is available yet for this article.
December 6, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29220428/sexual-dysfunction-in-patients-with-ibd-is-not-just-a-matter-of-quality-of-life
#3
Jens Walldorf, Patrick Michl
No abstract text is available yet for this article.
December 6, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29220427/steroid-but-not-biological-therapy-elevates-the-risk-of-venous-thromboembolic-events-in-inflammatory-bowel-disease-a-meta-analysis
#4
Patricia Sarlos, Kata Szemes, Peter Hegyi, Andras Garami, Imre Szabo, Anita Illes, Margit Solymar, Erika Petervari, Aron Vincze, Gabriella Par, Judit Bajor, Jozsef Czimmer, Orsolya Huszar, Peter Varju, Nelli Farkas
Background and aim: Inflammatory bowel disease [IBD] is associated with 1.5- to 3-fold increased risk of venous thromboembolic events [VTE]. The aim of this study was to determine the risk of VTE in IBD as a complication of systemic corticosteroids and anti-tumor necrosis factor alpha [TNFα] therapies. Methods: A systematic review and meta-analysis was conducted, which conforms to the Preferred Reporting Items for Systematic Reviews and Meta-analyses [PRISMA] statement...
December 6, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29216349/developing-a-standard-set-of-patient-centred-outcomes-for-inflammatory-bowel-disease-an-international-cross-disciplinary-consensus
#5
Andrew H Kim, Charlotte Roberts, Brian G Feagan, Rupa Banerjee, Willem Bemelman, Keith Bodger, Marc Derieppe, Axel Dignass, Richard Driscoll, Ray Fitzpatrick, Janette Gaarentstroom-Lunt, Peter D Higgins, Paulo Gustavo Kotze, Jillian Meissner, Marian O'Connor, Zhi-Hua Ran, Corey A Siegel, Helen Terry, Welmoed K van Deen, C Janneke van der Woude, Alandra Weaver, Suk-Kyun Yang, Bruce E Sands, Séverine Vermeire, Simon Pl Travis
Background and Aims: Success in delivering value-based healthcare involves measuring outcomes that matter most to patients. Our aim was to develop a minimum Standard Set of patient-centred outcome measures for inflammatory bowel disease (IBD), for use in different healthcare settings. Methods: An international working group (n=25) representing patients, patient associations, gastroenterologists, surgeons, specialist nurses, IBD registries and patient-reported outcome measure (PROM) methodologists participated in a series of teleconferences incorporating a modified Delphi process...
December 5, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29211912/intestinal-t-cell-profiling-in-inflammatory-bowel-disease-linking-t-cell-subsets-to-disease-activity-and-disease-course
#6
Carolijn Smids, Carmen S Horjus Talabur Horje, Julia Drylewicz, Britt Roosenboom, Marcel J M Groenen, Elly van Koolwijk, Ellen G van Lochem, Peter J Wahab
Introduction: A dysregulated intestinal T-cell response is presumed in patients with Inflammatory Bowel Disease (IBD). In this longitudinal study, we investigated the changes in intestinal T lymphocyte subsets in IBD at first presentation and over time during endoscopic active or inactive disease and relate them to disease activity and outcome. Material & method: We included 129 newly diagnosed patients (87 Crohn´s Disease (CD), 42 ulcerative colitis (UC)) and 19 healthy controls (HC)...
December 4, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29211899/exome-sequencing-and-genotyping-identify-a-rare-variant-in-nlrp7-gene-associated-with-ulcerative-colitis
#7
Alexandros Onoufriadis, Kristina Stone, Antreas Katsiamides, Ariella Amar, Yasmin Omar, Katrina de Lange, Kirstin Taylor, Jeffrey C Barrett, Richard Pollok, Bu'Hussain Hayee, John C Mansfield, Jeremy D Sanderson, Michael A Simpson, Christopher G Mathew, Natalie J Prescott
Background and aims: Although genome-wide association studies (GWAS) in inflammatory bowel disease (IBD) have identified a large number of common disease susceptibility alleles for both Crohn's disease (CD) and ulcerative colitis (UC), a substantial fraction of IBD heritability remains unexplained, suggesting that rare coding genetic variants may also have a role in pathogenesis. We used high-throughput sequencing in families with multiple cases of IBD, followed by genotyping of cases and controls, to investigate whether rare protein altering genetic variants are associated with susceptibility to IBD...
December 4, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29194468/characteristics-of-fecal-microbiota-in-pediatric-crohn-s-disease-and-their-dynamic-changes-during-infliximab-therapy
#8
Yizhong Wang, Xuefeng Gao, Amine Ghozlane, Hui Hu, Xiaolu Li, Yongmei Xiao, Dan Li, Guangjun Yu, Ting Zhang
Background: Crohn's disease [CD] is known to be associated with gut microbial dysbiosis. Infliximab [IFX] is increasingly used to treat pediatric CD, however it is not clear how gut microbiota is modified during IFX treatment. The aim of this study was to characterize the fecal microbiota community composition in pediatric CD patients and to assess its dynamic changes during IFX therapy. Methods: 16S rRNA sequencing approach was applied to determine the compositions of microbial communities in fecal samples...
November 29, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29194463/efficacy-of-endoscopic-balloon-dilation-for-small-bowel-strictures-in-patients-with-crohn-s-disease-a-nationwide-multi-center-open-label-prospective-cohort-study
#9
Fumihito Hirai, Akira Andoh, Fumiaki Ueno, Kenji Watanabe, Naoki Ohmiya, Hiroshi Nakase, Shingo Kato, Motohiro Esaki, Yutaka Endo, Hironori Yamamoto, Toshiyuki Matsui, Mitsuo Iida, Toshifumi Hibi, Mamoru Watanabe, Yasuo Suzuki, Takayuki Matsumoto
Background and Aims: Endoscopic balloon dilation (EBD) is an alternative to surgery for Crohn's strictures. However, there have been no prospective studies of EBD for small bowel strictures in patients with Crohn's disease (CD). The aim of this study was to clarify the efficacy and safety of EBD using balloon-assisted enteroscopy (BAE) for small bowel strictures in CD. Methods: This was a nationwide, multi-center, open-label, prospective cohort study. The subjects were CD patients with at least one symptom (abdominal pain, abdominal bloating, nausea) attributable to small bowel stricture...
November 29, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29186372/irritable-bowel-like-symptoms-in-ulcerative-colitis-are-as-common-in-patients-in-deep-remission-as-with-inflammation-results-from-a-population-based-study-the-ibsen-study
#10
Magne Henriksen, Marte Lie Høivik, Lars-Petter Jelsness-Jørgensen, Bjørn Moum
Background and aims: An increased prevalence of irritable bowel syndrome (IBS)-like symptoms has been reported in patients with ulcerative colitis (UC). Whether ongoing inflammation increases the prevalence of such symptoms is unknown. The aims of this study were to determine the prevalence of IBS-like symptoms in a population-based cohort of UC patients 20 years after diagnosis and to assess the possible association between such symptoms and ongoing inflammation. Methods: Patients diagnosed with UC between 1990 and 1994 in a geographically well-defined area were included in a prospective follow-up study and IBS symptoms according to Rome III criteria were recorded 20 years after diagnosis...
November 27, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29182760/expression-patterns-of-tnf%C3%AE-madcam1-and-stat3-in-intestinal-and-skin-manifestations-of-inflammatory-bowel-disease
#11
Stephan R Vavricka, Jose A Galván, Heather Dawson, Alex Soltermann, Luc Biedermann, Michael Scharl, Alain M Schoepfer, Gerhard Rogler, Mareike B Prinz Vavricka, Luigi Terracciano, Alexander Navarini, Inti Zlobec, Alessandro Lugli, Thomas Greuter
Background: Pathogenesis of cutaneous extraintestinal manifestations (EIM) in inflammatory bowel disease (IBD) remains elusive. Efficacy of anti-TNF agents suggests TNF-dependent mechanisms. The role of other biologics such as anti-integrins or JAK-inhibitors is not yet clear. Methods: We performed immunohistochemistry for TNFα, NFκB, STAT1/STAT3, MAdCAM1, CD20/68, caspase 3/9, IFNγ, Hsp-27/70 on 240 intestinal (55 controls, 185 IBD) and 64 skin biopsies (11 controls, 18 Erythema nodosum (EN), 13 Pyoderma gangenosum (PG), 22 psoriasis)...
November 22, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29182750/capsule-endoscopy-validation-of-the-magnetic-enterography-global-score-in-patients-with-established-crohn-s-disease
#12
Eyal Klang, Marianne M Amitai, Adi Lahat, Doron Yablecovitch, Benjamin Avidan, Sandra Neuman, Nina Levhar, Noa Rozendorn, Batya Weiss, Shomron Ben-Horin, Rami Eliakim, Uri Kopylov
Aims: To compare the evaluation of the small bowel inflammation by MEGS and CE-derived quantitative score (the Lewis score(LS). Methods: CD patients in stable clinical remission were prospectively recruited and underwent MRE and CE; fecal calprotectin (FC) levels were obtained. MEGS score was calculated for each SB segment and the entire SB (SBMEGS). SB inflammation on CE was quantified using LS. Cumulative Lewis score (C-LS) was calculated by summation of three tertiles scores...
November 22, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29165666/differences-in-outcomes-over-time-with-exclusive-enteral-nutrition-compared-to-steroids-in-children-with-mild-to-moderate-crohn-s-disease-results-from-the-growth-cd-study
#13
Noa Cohen-Dolev, Malgorata Sladek, Seamus Hussey, Dan Turner, Gabor Veres, Sibylle Koletzko, Javier Martin de Carpi, Annamaria Staiano, Ron Shaoul, Paolo Lionetti, Jorge Amil Dias, Anders Paerregaard, Federica Nuti, Tamar Pfeffer Gik, Tomer Ziv-Baran, Sivan Ben Avraham Shulman, Chen Sarbagili Shabat, Rotem Sigall Boneh, Richard K Russell, Arie Levine
Background: Exclusive enteral nutrition (EEN) and corticosteroids (CS) both induce similar rates of remission in mild to moderate pediatric Crohn's disease (CD), but differ with regard to mucosal healing. Our goal was to evaluate if EEN at diagnosis was superior to CS for improving long term outcomes. Methods: We prospectively followed newly diagnosed children <17 years with mild to moderate disease at baseline for two years in the GROWTH CD study. Patients were evaluated at baseline and at 8, 12, 78, and 104 weeks...
November 18, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29155985/a-systematic-review-the-management-and-outcomes-of-ileal-pouch-strictures
#14
Jonathan P Segal, Guy Worley, Samuel O Adegbola, Kapil Sahnan, Philip Tozer, Phillip F C Lung, Omar D Faiz, Susan K Clark, Ailsa L Hart
Background: Restorative proctocolectomy with ileal pouch-anal anastomosis removes the diseased tissue in ulcerative colitis but also allows gastrointestinal continuity and stoma-free living. Pouch strictures are a complication with a reported incidence of 5-38%. The three areas where pouch strictures occur are in the pouch inlet, mid-pouch and pouch-anal anastomosis. Aim: To undertake a systematic review of the literature and to identify management strategies available for pouch-anal, mid-pouch and pre-pouch ileal strictures and their outcomes...
November 16, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29145599/a-role-for-thiopurine-metabolites-in-the-synergism-between-thiopurines-and-infliximab-in-inflammatory-bowel-disease
#15
Ditte V Mogensen, Jørn Brynskov, Mark A Ainsworth, Jacob Nersting, Kjeld Schmiegelow, Casper Steenholdt
Background: Interactions between principal cytotoxic thiopurine metabolites, 6-thioguanine nucleotides (6-TGN), and infliximab (IFX) and anti-IFX antibodies (Abs) may contribute to higher effectiveness of IFX-thiopurine-combination therapy than monotherapies in inflammatory bowel disease. Methods: To examine if thiopurine metabolites influenced trough IFX and anti-IFX Abs, 89 patients previously assessed for anti-IFX Abs were included. To assess if IFX influenced thiopurine metabolites, 8 patients having responded to 12 weeks of intensified IFX at a constant thiopurine dosing were included...
November 14, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29145572/difference-in-clinical-course-genetics-and-the-microbiome-between-familial-and-sporadic-inflammatory-bowel-diseases
#16
Nienke Z Borren, Grace Conway, John J Garber, Hamed Khalili, Shrish Budree, Himel Mallick, Vijay Yajnik, Ramnik J Xavier, Ashwin N Ananthakrishnan
Objective: Family history is the strongest risk factor for developing Crohn's disease (CD) or ulcerative colitis (UC). We investigated whether the proximity of relationship with the affected relative and concordance for type of IBD modifies the effect of family history on phenotype and disease severity. Design: This cross-sectional study included patients with a confirmed diagnosis of IBD in a clinical registry. Family history of IBD was assessed by a questionnaire ascertaining presence of disease in a 1 st degree, 2 nd degree or a distant relative...
November 14, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29145562/ulcerative-colitis-endoscopic-index-of-severity-is-feasible-and-useful-for-endoscopic-activity-evaluation-in-ulcerative-colitis-patients-in-real-life-setting
#17
Cristiano Pagnini, Benedetta Maria Mariani, Roberto Lorenzetti
No abstract text is available yet for this article.
November 14, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29136128/the-proton-activated-receptor-gpr4-modulates-intestinal-inflammation
#18
Yu Wang, Cheryl de Vallière, Pedro H Imenez Silva, Irina Leonardi, Sven Gruber, Alexandra Gerstgrasser, Hassan Melham, Achim Weber, Katharina Leucht, Lutz Wolfram, Martin Hausmann, Carsten Krieg, Koray Thomasson, Onur Boyman, Isabelle Frey-Wagner, Gerhard Rogler, Carsten A Wagner
BACKGROUND AND AIMS: During active inflammation tissue intraluminal intestinal pH is decreased in patients with inflammatory bowel disease (IBD). Acidic pH may play a role in IBD pathophysiology. Recently, proton sensing G-protein coupled receptors were identified, including GPR4, OGR1 (GPR68), and TDAG8 (GPR65). We investigated whether GPR4 is involved in intestinal inflammation. METHODS: The role of GPR4 was assessed in murine colitis models: chronic dextran sulphate sodium (DSS) administration and by crossbreeding into an IL-10 deficient background for development of spontaneous colitis...
November 9, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29121178/exploration-of-predictive-biomarkers-of-early-infliximab-response-in-acute-severe-colitis-a-prospective-pilot-study
#19
Lauren Beswick, Ourania Rosella, Gennaro Rosella, Belinda Headon, Miles P Sparrow, Peter R Gibson, Daniel R van Langenberg
Background: Outcomes of acute severe ulcerative colitis (ASUC) appear dependent on early intervention with the first and/or further infliximab(IFX) doses, though parameters to guide decision-making remain uncertain. Aim: To assess whether serum/faecal IFX levels and inflammatory biomarkers early post-IFX dose can predict ASUC outcomes. Methods: This prospective pilot study consecutively recruited inpatients with steroid-refractory ASUC, who then received 1-3 IFX rescue doses (5mg/kg/dose) per treating clinician's discretion...
November 7, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29126103/salazosulfapyridine-related-stevens-johnson-syndrome-caused-by-sulfapyridine-and-confirmed-by-enzyme-linked-immunospot-assay
#20
Hao Xiong, Shengan Chen, Xiaoqun Luo
No abstract text is available yet for this article.
November 6, 2017: Journal of Crohn's & Colitis
journal
journal
41775
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"