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Journal of Crohn's & Colitis

Marianne Guirgis, Emily Wendt, Lai Mun Wang, Alissa Walsh, Daniel Burger, Robert V Bryant, Alex Kent, Rebecca Adamson, Oliver Brain, Simon P L Travis, Satish Keshav
BACKGROUND AND AIMS: Histological remission and low faecal calprotectin are positive prognostic factors in ulcerative colitis [UC]. Intramucosal calprotectin [iMC], which can be readily determined by immunohistochemistry, has not so far been evaluated as a predictor of outcome in UC. We aimed to investigate the relationship between iMC and clinical, endoscopic, and histological measures of remission in UC, and the independent prognostic value of iMC. METHODS: Ambulant patients with UC were recruited for a study comparing clinical activity indices...
November 14, 2016: Journal of Crohn's & Colitis
Lorant Gonczi, Zsuzsanna Vegh, Petra Anna Golovics, Mariann Rutka, Krisztina Barbara Gecse, Renata Bor, Klaudia Farkas, Tamás Szamosi, László Bene, Beáta Gasztonyi, Tünde Kristóf, László Lakatos, Pál Miheller, Károly Palatka, Mária Papp, Árpád Patai, Ágnes Salamon, Gábor Tamás Tóth, Áron Vincze, Edina Biro, Barbara Dorottya Lovasz, Zsuzsanna Kurti, Zoltan Szepes, Tamás Molnár, Péter L Lakatos
BACKGROUND AND AIMS: Biosimilar infliximab CT-P13 received European Medicines Agency (EMA) approval in June 2013 for all indications of the originator product. In the present study we aimed to evaluate the predictors of short- and medium-term clinical outcome in patients treated with the biosimilar infliximab at the participating IBD centres in Hungary. METHODS: Demographic data were collected and a harmonized monitoring strategy was applied. Clinical and biochemical activity were evaluated at weeks 14, 30 and 54...
November 12, 2016: Journal of Crohn's & Colitis
Amy L Lightner, Edward V Loftus
No abstract text is available yet for this article.
November 5, 2016: Journal of Crohn's & Colitis
E Zittan, B Kabakchiev, O B Kelly, R Milgrom, G C Nguyen, K Croitoru, A H Steinhart, M S Silverberg
BACKGROUND: There is a need for better, less-invasive disease activity indices that provide a representative assessment of endoscopic disease activity. We developed a new clinical score that incorporates the Harvey-Bradshaw index (HBI) with modified patient-reported outcomes (PROp), and physician (clinician) reported outcomes (PROc) and assessed its ability to measure endosopic disease activity in ileocolonic Crohn's disease (CD). METHODS: A cohort of 88 CD patients undergoing colonoscopy was accrued in a prospective fashion...
November 5, 2016: Journal of Crohn's & Colitis
Dessalegn Y Melesse, Lisa M Lix, Zoann Nugent, Laura E Targownik, Harminder Singh, James F Blanchard, Charles N Bernstein
OBJECTIVE: To develop a predictive model of disease course in inflammatory bowel disease (IBD) using health care utilization measures from administrative health data, and to apply this model to estimate disease course at a population level over time. METHODS: Study participants were IBD patients who were prospectively followed for a one-year period between 2009 and 2010 in a Canadian clinic setting to assess their IBD disease course (i.e., remission, mild, moderate, severe)...
November 4, 2016: Journal of Crohn's & Colitis
Maren C Karreman, Jolanda J Luime, Johanna M W Hazes, Angelique E A M Weel
BACKGROUND & AIMS: Inflammatory Bowel Disease is a chronic disease which affects up to 0.5% of the population. Various extraintestinal manifestations occur, among which rheumatic manifestations, grouped together under the name spondyloarthritis. The objective of the systematic review and meta-analysis was to give a systematic overview of the prevalence and incidence of spondyloarthritis in patients with inflammatory bowel disease. METHODS: We systematically searched Embase, Pubmed, OvidSP, Scopus and Web-of-science databases from inception to August 2016...
November 4, 2016: Journal of Crohn's & Colitis
Mohammad El Mouzan, Feng Wang, Mohammad Al Mofarreh, Rajita Menon, Ahmad Al Barrag, Kirill S Korolev, Ahmad Al Sarkhy, Mona Al Asmi, Yassin Hamed, Anjum Saeed, Scot Dowd, Asaad Assiri, Harland Winter
BACKGROUND & AIMS: although increasing evidence suggests a role for fungi in inflammatory bowel disease (IBD), data are scarce and mostly from adults. Our aim was to define the characteristics of fungal microbiota in newly-diagnosed treatment-naïve children with Crohn disease (CD). METHODS: The children referred for colonoscopy were prospectively enrolled in the study at King Khalid University Hospital, King Saud University and Al Mofarreh Polyclinics in Riyadh...
November 3, 2016: Journal of Crohn's & Colitis
Michael Eberhardson, Per Karlén, Ludvig Linton, Petra Jones, Annelie Lindberg, Martina Jones Kostalla, Emma Lindh, Anders Odén, Hans Glise, Ola Winqvist
BACKGROUND AND AIMS: Ulcerative colitis patients display increased number of circulating pro-inflammatory HLA-DR(hi) monocytes expressing high levels of the gut homing chemokine receptor CCR9 and TNF-α. The aim of this first-in-man double blind randomized placebo controlled trial was to evaluate selective removal of circulating CCR9-expressing monocytes by leukapheresis in patients with moderate to severe ulcerative colitis with regards to safety, tolerability and immunological response...
November 2, 2016: Journal of Crohn's & Colitis
E Bequet, H Sarter, M Fumery, F Vasseur, L Armengol-Debeir, B Pariente, D Ley, C Spyckerelle, H Coevoet, J E Laberenne, L Peyrin-Biroulet, G Savoye, D Turck, C Gower-Rousseau
BACKGROUND AND AIMS: Very-early-onset inflammatory bowel disease (VEO-IBD) is a form of IBD that is distinct from that of children with an older onset. We compared changes over time in the incidence and phenotype at diagnosis between two groups according to age at IBD diagnosis: VEO-IBD diagnosed before the age of 6, and early-onset IBD (EO-IBD) diagnosed between 6 and 16 years of age. METHODS: Data were obtained from a cohort enrolled in a prospective French population-based registry from 1988 to 2011...
October 31, 2016: Journal of Crohn's & Colitis
Øistein Hovde, Marte Lie Høivik, Magne Henriksen, Inger Camilla Solberg, Milada Cvancarova Småstuen, Bjørn A Moum
BACKGROUND/AIMS: Whether patients with inflammatory bowel diseases (IBDs) have increased risk of developing cancer has been debated. The aims of the study were to determine the prevalence of intestinal/extraintestinal cancers in an IBD cohort 20 years after diagnosis and to assess whether these patients had an increased cancer- specific risk compared with a matched control population. METHODS: Patients with ulcerative colitis (UC) and Crohn's disease (CD) diagnosed 1990 - 1993 have been prospectively followed up for 20 years...
October 31, 2016: Journal of Crohn's & Colitis
Gionata Fiorino, Mathilde Morin, Stefanos Bonovas, Cristiana Bonifacio, Antonino Spinelli, Adeline Germain, Valérie Laurent, Camille Zallot, Laurent Peyrin-Biroulet, Silvio Danese
BACKGROUND AND AIMS: Bowel damage in Crohn's disease [CD] is defined as the presence of intestinal strictures, fistulas or abscesses. Early disease may represent a window of opportunity for timely intervention. We evaluated disease activity and severity by the Lémann Index [LI] and the Magnetic Resonance Index of Activity [MaRIA] score, and their prognostic value in early CD. METHODS: All consecutive patients diagnosed with CD in two referral centres, assessed by magnetic resonance imaging or computerized tomography, were prospectively included...
October 31, 2016: Journal of Crohn's & Colitis
Uri Kopylov, Rami Eliakim
No abstract text is available yet for this article.
October 26, 2016: Journal of Crohn's & Colitis
Thomas P C Chu, Gordon W Moran, Timothy R Card
BACKGROUND AND AIMS: Numerous studies have established that mortality risk in IBD patients is higher than the general population, but the causes of death have seldom been examined. We aimed to describe causes of death in IBD. METHODS: A matched cohort study using UK general practice data from Clinical Practice Research Datalink linked to death registration records. We described the distribution of causes of death among IBD patients by age at death and time since IBD diagnosis...
October 25, 2016: Journal of Crohn's & Colitis
Irene Marafini, Ivan Monteleone, Vincenzo Dinallo, Davide Di Fusco, Veronica De Simone, Federica Laudisi, Massimo Claudio Fantini, Antonio Di Sabatino, Francesco Pallone, Giovanni Monteleone
BACKGROUND AND AIM: The chemokine CCL20 is over-produced in epithelium of Crohn's disease [CD] patients and contributes to recruiting immune cells to inflamed gut. Tumour necrosis factor-α [TNF-α] is a powerful inducer of CCL20 in intestinal epithelial cells. In CD, high levels of Smad7 block the activity of transforming growth factor-β1 [TGF-β1], a negative regulator of TNF signalling. We investigated whether intestinal epithelial cell-derived CCL20 is negatively regulated by TGF-β1 and whether Smad7 knock-down reduces CCL20 in CD...
October 25, 2016: Journal of Crohn's & Colitis
Daniela Bojic, Keith Bodger, Simon Travis
Patient reported outcome measures PROMs are standardized, validated questionnaires intended for completion by patients in order to measure their perceptions of their own health condition or its treatment without interpretation of the patient's response by a clinician or anyone else. Mayo Clinic Score (MCS) or Crohn's Disease Activity Index (CDAI), most frequently used as endpoints in conventional clinical trials, are composite instruments that are not fully objective nor capture the impact of disease from the patient's perspective...
October 21, 2016: Journal of Crohn's & Colitis
William B Grant
No abstract text is available yet for this article.
October 20, 2016: Journal of Crohn's & Colitis
Christopher A Lamb, John C Mansfield, Gaik W Tew, Deena Gibbons, Anna K Long, Peter Irving, Lauri Diehl, Jeff Eastham-Anderson, Maria B Price, Graeme O'Boyle, David E J Jones, Sharon O'Byrne, Adrian Hayday, Mary E Keir, Jackson G Egen, John A Kirby
BACKGROUND AND AIMS: The αEβ7 integrin is crucial for retention of T lymphocytes at mucosal surfaces through its interaction with E-cadherin. Pathogenic or protective functions of these cells during human intestinal inflammation, such as ulcerative colitis (UC) have not previously been defined, with understanding largely derived from animal model data. Defining this phenotype in human samples is important for understanding UC pathogenesis and is of translational importance for therapeutic targeting of αEβ7:E-cadherin interactions...
October 20, 2016: Journal of Crohn's & Colitis
Andreas Sturm, Christian Maaser, Michael Mendall, Dimitrios Karagiannis, Pantelis Karatzas, Nienke Ipenburg, Shaji Sebastian, Fernando Rizzello, Jimmy Limdi, Konstantinos Katsanos, Carsten Schmidt, Steven Jeuring, Francesco Colombo, Paolo Gionchetti
This ECCO topical review of the European Crohn's and Colitis Organisation [ECCO] focuses on the epidemiology, pathophysiology, diagnosis, management and outcome of the two most common forms of inflammatory bowel disease, Crohn's disease and ulcerative colitis, in elderly patients. The objective was to reach expert consensus to provide evidence-based guidance for clinical practice.
October 20, 2016: Journal of Crohn's & Colitis
Shuji Hibiya, Kiichiro Tsuchiya, Ryohei Hayashi, Keita Fukushima, Nobukatsu Horita, Sho Watanabe, Tomoaki Shirasaki, Ryu Nishimura, Natsuko Kimura, Tatsunori Nishimura, Noriko Gotoh, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe
BACKGROUND & AIMS: Patients with ulcerative colitis (UC) are at an increased risk of developing colitis-associated cancer (CAC), suggesting that continuous inflammation in the colon promotes the transformation of colonic epithelial cells. However, the mechanisms underlying cell transformation in UC remain unknown. We therefore aimed to investigate the effect of long-term inflammation on intestinal epithelial cells (IECs) using organoid culture. METHODS: IECs were isolated from mice colon, and were cultured according to a method for a three-dimensional (3D) organoid culture...
October 11, 2016: Journal of Crohn's & Colitis
Walter Reinisch, Jean-Frédéric Colombel, Geert D'Haens, William J Sandborn, Paul Rutgeerts, Karel Geboes, Joel Petersson, Samantha Eichner, Qian Zhou, Anne M Robinson, Holly A Read, Roopal Thakkar
BACKGROUND AND AIMS: Mucosal healing [MH] is an important goal for patients with Crohn's disease [CD], yet is incompletely characterised. We investigated whether MH differed by segments across the colon and ileum in patients who received adalimumab maintenance treatment in the EXTEND study. METHODS: In this double-blind study in adults with moderate to severe ileocolonic CD and mucosal ulceration, all patients received adalimumab induction [Week 0, 160 mg; Week 2, 80 mg]...
October 10, 2016: Journal of Crohn's & Colitis
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