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Journal of Crohn's & Colitis

Amanda Ricciuto, Jasbir Dhaliwal, Thomas D Walters, Anne M Griffiths, Peter C Church
Background and aims: We undertook a systematic review and meta-analysis examining the effectiveness of therapeutic drug monitoring (TDM) to improve clinical outcomes in anti-TNF-treated IBD patients. Methods: We searched MEDLINE, Epub Ahead of Print, EMBASE and Cochrane through October 2017 for randomized trials (RCTs) and cohort studies comparing proactive or reactive TDM to each other or empiric care. Outcomes included clinical remission (primary), clinical relapse, endoscopic remission, anti-TNF response durability, cost and adverse events (secondary)...
August 10, 2018: Journal of Crohn's & Colitis
Mariangela Allocca, Gionata Fiorino, Stefanos Bonovas, Federica Furfaro, Daniela Gilardi, Marjorie Argollo, Paola Magnoni, Laurent Peyrin-Biroulet, Silvio Danese
Background: Colonoscopy (CS) is the standard for assessing disease activity in ulcerative colitis (UC), although invasive and poorly tolerated. Bowel ultrasound (BUS) may be a valid alternative in UC patients, however the comparative accuracy between BUS and CS is unknown. Methods: Consecutive patients with UC were prospectively assessed by CS and BUS. Colonic wall thickening (CWT >3 mm), colonic wall flow at Power Doppler (CWF), colonic wall pattern (CWP) and presence of lymph nodes evaluated at BUS were compared with CS...
August 4, 2018: Journal of Crohn's & Colitis
Colm B Collins, Pamela R Puthoor, Tom T Nguyen, Paul Jedlicka, Jacob E Friedman, Edwin F de Zoeten
Background and Aims: Inflammatory Bowel Diseases (IBD) are chronic intestinal inflammatory conditions in part mediated by CD4+ T cells. Anti-inflammatory Foxp3+ regulatory T cells (Treg) maintain immune homeostasis and protect against IBD development via multiple mechanisms including cytokine secretion and cell-cell interaction. CCAAT enhancer binding protein-beta (C/EBPβ) is a stress-responsive transcription factor linked with IBD susceptibility. Whole-body C/EBPβ deficiency induces CD4+ T cell-predominant hyperproliferation and we hypothesize that this may be due to impaired Treg function...
July 31, 2018: Journal of Crohn's & Colitis
Carlos Taxonera, Ángel Ponferrada, Sabino Riestra, Fernando Bermejo, Cristina Saro, María Dolores Martín-Arranz, José Luis Cabriada, Manuel Barreiro-de Acosta, María Luisa de Castro, Pilar López-Serrano, Jesús Barrio, Cristina Suarez, Eva Iglesias, Federico Argüelles-Arias, Isabel Ferrer, Ignacio Marín-Jiménez, Alejandro Hernández-Camba, Guillermo Bastida, Manuel Van Domselaar, Pilar Martínez-Montiel, David Olivares, Montserrat Rivero, Luis Fernandez-Salazar, Óscar Nantes, Olga Merino, Cristina Alba, Javier P Gisbert
Aim: To assess the likelihood of detecting latent tuberculosis infection (LTBI) by the positive conversion of a serial tuberculin skin test (TST) at 1 year in inflammatory bowel disease (IBD) patients with negative baseline 2-step TST. Methods: In this multicentre prospective cohort study we evaluated rate and predictors of conversion of TST at 1 year in patients with negative baseline TST. We also evaluated management of patients who had a positive TST at baseline or a conversion at 1 year...
July 21, 2018: Journal of Crohn's & Colitis
Sudha Visvanathan, Patrick Baum, Azucena Salas, Richard Vinisko, Ramona Schmid, Kristie M Grebe, Justin W Davis, Kori Wallace, Wulf O Böcher, Steven J Padula, Jay S Fine, Julián Panés
Background and Aims: To investigate the underlying mechanism of action of risankizumab, a monoclonal antibody targeting the IL-23 p19 subunit, previously reported to induce clinical and endoscopic remission in a randomised phase II study in patients with active Crohn's disease. Methods: Ileum and colon biopsies obtained at screening and Week 12 from a subgroup of patients (N=106) in the risankizumab phase II study were analysed by transcriptome-wide RNA-seq profiling...
July 19, 2018: Journal of Crohn's & Colitis
Fay Probert, Alissa Walsh, Marta Jagielowicz, Tianrong Yeo, Timothy D W Claridge, Alison Simmons, Simon Travis, Daniel C Anthony
Background & aims: Endoscopic assessment of ulcerative colitis (UC) is one of the most accurate measures of disease activity, but frequent endoscopic investigations are disliked by patients and expensive for the health care system. A minimally-invasive test that provides a surrogate measure of endoscopic activity is required. Methods: Plasma Nuclear Magnetic Resonance (NMR) spectra from 40 patients with UC followed prospectively over 6 months were analysed with multivariate statistics...
July 17, 2018: Journal of Crohn's & Colitis
Magali de Bruyn, Marc Ferrante
No abstract text is available yet for this article.
July 16, 2018: Journal of Crohn's & Colitis
Manuela Maria Estevinho, Joana Afonso, Isadora Rosa, Paula Lago, Eunice Trindade, Luís Correia, Cláudia Camila Dias, Fernando Magro
Background and aims: Placebo effect in health-related quality of life (HRQoL) of inflammatory bowel disease (IBD) patients has been poorly characterized. This systematic review and meta-analysis aimed to assess i) mean improvements in IBDQ (Inflammatory Bowel Disease Questionnaire) and SF-36 (36-Item Short Form Health Survey) scores among placebo-treated patients; ii) the proportion of placebo-treated patients achieving IBDQ-defined response and remission and correspondent odds ratios (OR)...
July 14, 2018: Journal of Crohn's & Colitis
Shijie Geng, Saisai Cheng, Yuan Li, Zhengshun Wen, Xin Ma, Xuemei Jiang, Yizhen Wang, Xinyan Han
Background and Aims: Fecal microbiota transplantation [FMT] has shown promise as a treatment for inflammatory bowel disease [IBD]. Using a piglet model, our previous study indicated that exogenous fecal microbiota can enhance gastrointestinal health through enhancing intestinal barrier. However, specific connections between FMT-induced microbial changes and modulation of intestinal barrier still remain to be fully illustrated. Here, we aimed to determine the potential role of metabolic function of gut microbiota in the beneficial effects of FMT...
July 14, 2018: Journal of Crohn's & Colitis
Marie-Lise Thierry, Hélène Rousseau, Lieven Pouillon, Mélanie Girard-Gavanier, Cédric Baumann, Anthony Lopez, Silvio Danese, Valérie Laurent, Laurent Peyrin-Biroulet
Background and Aims: The Nancy score is a luminal Crohn's disease (CD) activity index applied in diffusion-weighted magnetic resonance imaging (DW-MRI). We assessed the accuracy of the Nancy score in detecting mucosal healing and treatment response, and predicting surgery. Methods: Retrospective, single-centre study of all patients with active CD and serial DW-MRI before and after treatment initiation with a biological, between January 2010 and September 2016. Gold standard was endoscopy...
July 9, 2018: Journal of Crohn's & Colitis
Peter Bossuyt, Edouard Louis, Jean-Yves Mary, Séverine Vermeire, Yoram Bouhnik
Endoscopic remission is the cornerstone of drug development and the guidance for daily clinical practice in Crohn's disease. But although scoring systems for endoscopic activity in CD are available for more than 3 decades, no consensus exists on the definition of endoscopic remission. In this viewpoint we describe the shortcomings of the current definition of endoscopic remission in ileocolonic CD and the essential requirements for a newly developed endoscopic scoring tool for endoscopic remission in CD.
July 6, 2018: Journal of Crohn's & Colitis
Mariangela Allocca, Gionata Fiorino, Cristiana Bonifacio, Federica Furfaro, Daniela Gilardi, Marjorie Argollo, Laurent Peyrin-Biroulet, Silvio Danese
Background: The comparative accuracy of bowel ultrasound (US) versus magnetic resonance enterography (MRE) in combination with colonoscopy (CS) in assessing Crohn's disease (CD) and influencing the decision-making process is unknown. Methods: Ileo-colonic CD consecutive patients seen in a tertiary referral Center were prospectively assessed by MRE, CS, and bowel US, within 1 week. Sensitivity, specificity, accuracy, PPV and NPV of bowel US in assessing localization, enhancement (presence of vascularization at Power Doppler), active disease (presence of ulcers at colonoscopy), strictures, fistulas and abscesses were calculated using CS + MRE findings together as a reference standard...
July 5, 2018: Journal of Crohn's & Colitis
Mike van der Have, Bas Oldenburg, Ad A Kaptein, Jeroen M Jansen, Robert C H Scheffer, Bas A van Tuyl, Andrea E van der Meulen-de Jong, Marieke Pierik, Peter D Siersema, Martijn G H van Oijen, Herma H Fidder
No abstract text is available yet for this article.
June 30, 2018: Journal of Crohn's & Colitis
Chen Yang, Xiaowen Huang, Shixue Dai
No abstract text is available yet for this article.
June 27, 2018: Journal of Crohn's & Colitis
Stefanos Bonovas, Laurent Peyrin-Biroulet, Silvio Danese
No abstract text is available yet for this article.
June 27, 2018: Journal of Crohn's & Colitis
Weisong Shen, Yi Li, Lei Cao, Xingchen Cai, Yuanyuan Ge, Weiming Zhu
Background: Prox1 is a transcription factor necessary for lymphangiogenesis and lymphatic function. The aim of the study was to assess the correlation between the expression of Prox1 and postoperative recurrence in Crohn's Disease (CD). Methods: Forty CD patients who underwent ileocolonic resection were included. Expression levels of Prox1 and D2-40 were detected using immunohistochemistry. Expression levels of Prox1, VEGFR3, and VEGFC protein were also detected in fresh CD specimens using western blotting and Q-PCR...
June 26, 2018: Journal of Crohn's & Colitis
Ryo Ozaki, Taku Kobayashi, Shinji Okabayashi, Masaru Nakano, Shojiroh Morinaga, Atsuko Hara, Makoto Ohbu, Kentaro Matsuoka, Takahiko Toyonaga, Eiko Saito, Tadakazu Hisamatsu, Toshifumi Hibi
Background and Aims: The current goal of treatment for ulcerative colitis (UC) is endoscopic and ultimately histological mucosal healing. However, there is no consensus on the definition of histological mucosal healing. We evaluated histological risk factors for clinical relapse in UC patients with endoscopically normal mucosa to focus on the importance of histological evaluation. Methods: Patients with UC who underwent colonoscopy confirming Mayo endoscopic subscore (MES) ≤ 1 with biopsies were enrolled into this retrospective cohort...
June 25, 2018: Journal of Crohn's & Colitis
Kelly C Cushing, Hamed Kordbacheh, Michael S Gee, Avinash Kambadakone, Ashwin N Ananthakrishnan
No abstract text is available yet for this article.
June 23, 2018: Journal of Crohn's & Colitis
Frank M Ruemmele, Joel Rosh, William A Faubion, Marla C Dubinsky, Dan Turner, Andreas Lazar, Samantha Eichner, Jen-Fue Maa, Gabriela Alperovich, Anne M Robinson, Jeffrey S Hyams
Background and Aims: Adalimumab has been shown to be more effective than placebo in healing fistulae in adults with moderately to severely active Crohn's disease. The efficacy and safety of adalimumab in healing fistulae in children/adolescents with Crohn's disease from the 52-week IMAgINE 1 clinical trial, and its open-label extension IMAgINE 2, are reported. Methods: Children/adolescents with perianal fistulae at baseline of IMAgINE 1 were assessed for fistula closure and improvement during IMAgINE 1 [Week 0-52] and from Week 0 of IMAgINE 2 [Week 52 of IMAgINE 1] through to Week 240 of IMAgINE 2 using non-responder imputation...
June 22, 2018: Journal of Crohn's & Colitis
Allyson Wyatt, Richard Kellermayer
No abstract text is available yet for this article.
June 20, 2018: Journal of Crohn's & Colitis
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