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Journal of Crohn's & Colitis

Tomás Ripollés, María Jesús Martínez-Pérez, José María Paredes, José Vizuete, Gregorio Martin
Background: the literature shows that contrast-enhanced ultrasound (CEUS) is superior to wall thickness or color Doppler imaging (CDI) in predicting disease activity using endoscopy as the reference standard. Objective: to determine in patients with Crohn´s disease (CD) whether the evaluation of wall thickness or CDI before CEUS examination could help decide when the injection of contrast agent is justified as a means for detecting disease activity as determined at endoscopy, without reducing the accuracy of ultrasound...
December 8, 2018: Journal of Crohn's & Colitis
Gonçalo Nunes, Marta Patita, Vítor Fernandes
No abstract text is available yet for this article.
December 7, 2018: Journal of Crohn's & Colitis
Ana M Corraliza, Elena Ricart, Alicia López-García, Maria Carme Masamunt, Marisol Veny, Miriam Esteller, Aida Mayorgas, Lionel Le Bourhis, Matthieu Allez, Núria Planell, Sudha Visvanathan, Patrick Baum, Carolina España, Raquel Cabezón-Cabello, Daniel Benítez-Ribas, Montserrat Rovira, Julián Panés, Azucena Salas
Background and Aims: Recent studies show the efficacy of autologous hematopoietic stem cell transplantation (HSCT) in severely refractory Crohn's disease (CD) patients. HSCT is thought to eliminate auto-reactive cells; however, no specific studies of immune reconstitution in CD patients are available. Methods: We followed a group of CD patients (n=18) receiving autologous HSCT, with 50% of them achieving endoscopic drug-free remission. To elucidate the mechanisms driving efficacy, we monitored changes after HSCT in blood and intestine immune-cell composition...
December 6, 2018: Journal of Crohn's & Colitis
Sara Lovisa, Giannicola Genovese, Silvio Danese
Intestinal fibrosis is an inevitable complication in patients with inflammatory bowel disease (IBD), occurring in its two major clinical manifestations: ulcerative colitis and Crohn's disease. Fibrosis represents the final outcome of the host reaction to persistent inflammation which triggers a prolonged wound healing response resulting in the excessive deposition of extracellular matrix, eventually leading to intestinal dysfunction. The process of epithelial-to-mesenchymal transition (EMT) represents an embryonic program relaunched during wound healing, fibrosis and cancer...
December 6, 2018: Journal of Crohn's & Colitis
Elena Vegni, Daniela Gilardi, Stefanos Bonovas, Bianca E Corrò, Julia Menichetti, Daniela Leone, Allocca Mariangela, Federica Furfaro, Silvio Danese, Gionata Fiorino
Background: Inflammatory bowel diseases [IBD] are characterised by significant quality of life [QoL] impairment, as well as illness perception. Assessing illness perception may help in optimising the management of IBD patients. Methods: In this single-centre, observational, transversal study, consecutive adult IBD patients were enrolled and stratified according to disease activity [active/remission]. The Revised Illness Perception Questionnaire [IPQ-R], based on identity, opinions, and causes of their disease was administered to all patients...
December 4, 2018: Journal of Crohn's & Colitis
Anne Grosen, Mona Bungum, Lisbet Ambrosius Christensen, Eugenia Cordelli, Ole Halfdan Larsen, Giorgio Leter, Mette Julsgaard, Thea Vestergaard, Paola Villani, Christian Lodberg Hvas, Jens Kelsen
Background & Aims: The impact of severe inflammation on semen quality, including sperm DNA integrity, in men with inflammatory bowel disease (IBD) is unknown, as are the potential effects of anti-tumour necrosis factor-alpha (TNF-alpha) therapy. We investigated the influence of severe active IBD and anti-TNF-alpha treatment on semen quality. Methods: We prospectively included 20 patients admitted with severe active IBD. Further, 19 patients who initiated and 17 who stopped anti-TNF-alpha therapy were included...
November 30, 2018: Journal of Crohn's & Colitis
Yoichi Kakuta, Yosuke Kawai, Takeo Naito, Atsushi Hirano, Junji Umeno, Yuta Fuyuno, Zhenqiu Liu, Dalin Li, Takeru Nakano, Yasuhiro Izumiyama, Ryo Ichikawa, Daisuke Okamoto, Hiroshi Nagai, Shin Matsumoto, Katsutoshi Yamamoto, Naonobu Yokoyama, Hirofumi Chiba, Yusuke Shimoyama, Motoyuki Onodera, Rintaro Moroi, Masatake Kuroha, Yoshitake Kanazawa, Tomoya Kimura, Hisashi Shiga, Katsuya Endo, Kenichi Negoro, Jun Yasuda, Motohiro Esaki, Katsushi Tokunaga, Minoru Nakamura, Takayuki Matsumoto, Dermot P B McGovern, Masao Nagasaki, Yoshitaka Kinouchi, Tooru Shimosegawa, Atsushi Masamune
Background and Aims: Genome-wide association studies (GWASs) of European populations have identified numerous susceptibility loci for Crohn's disease (CD). Susceptibility genes differ by ethnicity, however, so GWASs specific for Asian populations are required. This study aimed to clarify the Japanese-specific genetic background for CD by a GWAS using the Japonica array (JPA) and subsequent imputation with the 1KJPN reference panel. Methods: Two independent Japanese case/control sets (Tohoku region [379 CD patients, 1621 controls] and Kyushu region [334 CD patients, 462 controls]) were included...
November 29, 2018: Journal of Crohn's & Colitis
Marianne Forkel, Sophie van Tol, Charlotte Höög, Jakob Michaëlsson, Sven Almer, Jenny Mjösberg
Background and Aims: Innate lymphoid cells [ILC] have been suggested to play a role in inflammatory bowel disease [IBD]. Here, we investigated the ILC compartment in intestinal biopsies and blood from distinct patient groups with Crohn's disease [CD] and ulcerative colitis [UC], either newly diagnosed or with disease established for at least 1 year. This approach allowed us to simultaneously investigate temporal, disease-specific, and tissue-specific changes in ILC composition in IBD...
November 29, 2018: Journal of Crohn's & Colitis
André D'Hoore
No abstract text is available yet for this article.
November 29, 2018: Journal of Crohn's & Colitis
Marin J de Jong, Danielle Roosen, Juliette H R J Degens, Tim R A van den Heuvel, Marielle Romberg, W Hameeteman, Alexander G L Bodelier, Igor Romanko, Milan Lukas, Bjorn Winkens, Tineke Markus, Ad A M Masclee, Astrid van Tubergen, Daisy M A E Jonkers, Marie J Pierik
BACKGROUND & AIMS: Patient-reported outcome measures (PROMs) assessing inflammatory bowel disease (IBD) activity are of interest for monitoring in clinical practice, telemedicine systems or trials. Different PROMs for follow-up of disease activity are available; however, none was developed with endoscopy as golden standard. The objective of this study was to develop and validate a PROM to predict endoscopic disease activity following the recommendations of the Food and Drug Administration...
November 24, 2018: Journal of Crohn's & Colitis
Elisabeth Hain, Léon Maggiori, Marion Orville, Xavier Tréton, Yoram Bouhnik, Yves Panis
Background & Aims: Faecal diversion (FD) can be proposed in patients with refractory anoperineal Crohn's disease (APCD). This study aimed to assess long-term results of this strategy, following the advent of the anti-TNF era. Methods: All patients who underwent FD for refractory APCD between 2005 and 2017 were included, excluding patients with a history of ileal pouch-anal anastomosis. A multivariate analysis regarding absence of stoma reversal (SR) was performed...
November 19, 2018: Journal of Crohn's & Colitis
G R Jones, F Fascì-Spurio, N A Kennedy, N Plevris, P Jenkinson, M Lyons, L Wong, P MacLean, S Glancy, C W Lees
Background and Aims: Magnetic resonance enterography (MRE) is the gold standard for assessing ileal inflammation in Crohn's disease. The aim of the present study was to correlate faecal calprotectin (FC) to MRE via a simple score in an exclusive ileal cohort with long term follow up for association with time to surgery or biologic therapy. Methods: 150 MRE studies with matched FC (±30 days) were identified from the Edinburgh FC Register (2008-12; n=18,138). Scans were re-read blinded to clinical data, independently by 2 expert GI radiologists to generate a simple MRE score (range 0-10) from assessment of the worst segment plus total disease extent...
November 19, 2018: Journal of Crohn's & Colitis
Ben Kang, So Yoon Choi, Young Ok Choi, Soo-Youn Lee, Sun-Young Baek, Insuk Sohn, Byung-Ho Choe, Hae Jeong Lee, Yon Ho Choe
Background and Aims: Mucosal healing is an important treatment goal in Crohn's disease. We investigated the association between serum infliximab trough levels and mucosal healing, and the infliximab cut-off levels required for mucosal healing in paediatric patients. Methods: In this multicentre, retrospective, cross-sectional study, medical records and electronic data of paediatric patients with luminal Crohn's disease, who had received infliximab for ≥1 year, were examined...
November 19, 2018: Journal of Crohn's & Colitis
Alissa Walsh, Andrey Kormilitzin, Christopher Hinds, Vanashree Sexton, Oliver Brain, Satish Keshav, Holm Uhlig, John Geddes, Guy Goodwin, Michele Peters, Gary Collins, Simon Travis
Background: Faecal calprotectin (FCal) levels are used as a surrogate marker for mucosal inflammation, but thresholds for defining endoscopic or histological disease activity in ulcerative colitis (UC) remain unclear. Methods: Using validated indices, prospective measurements of FCal, symptoms (Simple Colitis Clinical Activity Index, SCCAI), endoscopic (Ulcerative Colitis Endoscopic Index of Severity, UCEIS) and histological activity (Nancy index) were made over 6 months in patients enrolled into the TrueColours UC web-based monitoring programme...
November 16, 2018: Journal of Crohn's & Colitis
Martha Zakrzewski, Lisa A Simms, Allison Brown, Mark Appleyard, James Irwin, Nicola Waddell, Graham L Radford-Smith
Background and aims: This study aimed to characterise the mucosa-associated microbiota in ileal Crohn's disease (CD) patients and in healthy controls in terms of host genotype and inflammation status. Methods: The mucosa-associated microbiota of intestinal pinch biopsies from 15 ileal CD patients with mild and moderate disease and from 58 healthy controls were analysed by 16S ribosomal sequencing to determine microbial profile differences between (1) IL23R, NOD2 and ATG16L1 genotypes in healthy subjects, (2) ileal CD patients and control subjects, and (3) inflamed and non-inflamed mucosal tissue in CD patients...
November 16, 2018: Journal of Crohn's & Colitis
C R H Hedin, S R Vavricka, A Stagg, A Schoepfer, T Raine, L Puig, U Pleyer, A Navarini, A van der Meulen, J Maul, K Katsanos, A Kagramanova, T Greuter, Y Gonzalez Lama, F van Gaalen, P Ellul, J Burisch, D Bettenworth, M D Becker, G Bamias, F Rieder
No abstract text is available yet for this article.
November 15, 2018: Journal of Crohn's & Colitis
Laure Benoit, Olivier Mir, Paul Berveiller
No abstract text is available yet for this article.
November 15, 2018: Journal of Crohn's & Colitis
Feihong Deng, Shuying He, Shudan Cui, Yanqiang Shi, Yuyong Tan, Zhijun Li, Chongyang Huang, Deliang Liu, Fachao Zhi, Liang Peng
BACKGROUND AND AIMS: Macrophages are a promising therapeutic target for intestinal mucosal repair. MiR-146b appears to control macrophage activation and cell proliferation. METHODS: By loading miR-146b mimic on mannose-modified trimethyl chitosan (MTC)-conjugated nanoparticles (NPs) (MTC-miR146b), a molecular targeted immunotherapeutic approach was developed to selectively target intestinal macrophages for mucosal regeneration and tumourigenesis in mouse models...
November 15, 2018: Journal of Crohn's & Colitis
Antonio F Di Narzo, Carrie Brodmerkel, Shannon E Telesco, Carmen Argmann, Lauren A Peters, Katherine Li, Brian Kidd, Joel Dudley, Judy Cho, Eric E Schadt, Andrew Kasarskis, Radu Dobrin, Ke Hao
Background: The molecular etiology of inflammatory bowel disease (IBD) and its two subtypes, ulcerative colitis (UC) and Crohn's disease (CD), have been carefully investigated at genome and transcriptome levels. Recent advances in high throughput proteome quantification has enabled comprehensive large scale plasma proteomics studies of IBD. Methods: The study used two cohorts: (1) CERTIFI-cohort: 42 sample from the CERTIFI trial of anti TNFα refractory CD patients; (2) PROgECT-UNITI-HC cohort: 46 UC samples PROgECT study, 84 CD samples of UNITI I and UNITI II, and 72 healthy controls recruited in Mount Sinai Hospital, New York, USA...
November 15, 2018: Journal of Crohn's & Colitis
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