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Journal of Chemical Biology

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https://www.readbyqxmd.com/read/28101254/jocb-bulletin
#1
(no author information available yet)
No abstract text is available yet for this article.
January 2017: Journal of Chemical Biology
https://www.readbyqxmd.com/read/28101253/2-chromon-3-yl-imidazole-derivatives-as-potential-antimicrobial-agents-synthesis-biological-evaluation-and-molecular-docking-studies
#2
Shweta Sharma, Vishal Sharma, Gurpreet Singh, Harpreet Kaur, Shubham Srivastava, Mohan Paul S Ishar
A series of novel 2-(chromon-3-yl)-4,5-diphenyl-1H-imidazoles (4a-h) were synthesized by one pot condensation of substituted 3-formylchromones (1a-h), benzil (2) and ammonium acetate (3) in refluxing acetic acid at 110 °C under N2 atmosphere. Allylation of compounds 4a-h with allyl bromide in the presence of fused K2CO3 furnished N-allyl-2-(chromon-3-yl)-4,5-diphenyl-1H-imidazoles (6a-h). The synthesized compounds were characterized spectroscopically and evaluated for in vitro antimicrobial activity against various pathogenic bacterial and fungal strains by disc diffusion method...
January 2017: Journal of Chemical Biology
https://www.readbyqxmd.com/read/28101252/identification-of-proteins-from-wild-cardoon-flowers-cynara-cardunculus-l-by-a-proteomic-approach
#3
Amal Ben Amira, Julien Bauwens, Edwin De Pauw, Souhail Besbes, Hamadi Attia, Frédéric Francis, Christophe Blecker
Proteomic approach was applied to identify total proteins, particularly the enzymatic content, from wild cardoon flowers. As the selection of an appropriate sample preparation method is the key for getting reliable results, two different extraction/precipitation methods (trichloroacetic acid and phenol/ammonium acetate) were tested on fresh and lyophilized flowers. After two-dimensional electrophoresis (2D-E) separations, a better protein pattern was obtained after phenol extraction from lyophilized flowers...
January 2017: Journal of Chemical Biology
https://www.readbyqxmd.com/read/28101251/antifungal-and-anthelmintic-activity-of-novel-benzofuran-derivatives-containing-thiazolo-benzimidazole-nucleus-an-in-vitro-evaluation
#4
R Kenchappa, Yadav D Bodke, Sandeep Telkar, M Aruna Sindhe
A novel series of thiazolo[3,2-a]benzimidazole derivatives containing benzofuran nucleus (5a-l) have been synthesized. The key intermediate, substituted benzimidazol-sulfanyl benzofuran ethanone (3a-d) was prepared by refluxing the mixture of substituted 2-acetyl benzofuran and substituted 2-mercaptobenzimidazole in acetic acid. The cyclisation of compounds (3a-d) using polyphosphoric acid furnished the corresponding 6-substituted benzofuran thiazolo[3,2-a]benzimidazoles (4a-d). Further, the cyclized compounds (4a-d) were subjected for Mannich reaction to give corresponding Mannich bases (5a-l)...
January 2017: Journal of Chemical Biology
https://www.readbyqxmd.com/read/28101250/is-phosphatidylglycerol-essential-for-terrestrial-life
#5
REVIEW
Samuel Furse
Lipids are of increasing importance in understanding biological systems. Lipids carrying an anionic charge are noted in particular for their electrostatic interactions with both proteins and divalent cations. However, the biological, analytical, chemical and biophysical data of such species are rarely considered together, limiting our ability to assess the true role of such lipids in vivo. In this review, evidence from a range of studies about the lipid phosphatidylglycerol is considered. This evidence supports the conclusions that this lipid is ubiquitous in living systems and generally of low abundance but probably fundamental for terrestrial life...
January 2017: Journal of Chemical Biology
https://www.readbyqxmd.com/read/27698951/jocb-bulletin
#6
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Journal of Chemical Biology
https://www.readbyqxmd.com/read/27698950/the-removal-of-mercury-ii-from-water-by-ag-supported-on-nanomesoporous-silica
#7
Mohammad Ali Azizi Ganzagh, Mardali Yousefpour, Zahra Taherian
In this study, the synthesis of SBA-15/Ag nanocomposite materials with different amounts of silver (2.5, 5, and 10 %) has been investigated under acidic conditions by using P123 as a template via the direct method. The nanocomposites of SBA-15 were synthesized by the same method and by the addition of silver salt. Finally, the nanocomposite materials were examined for the removal of mercury ions from wastewater as an adsorbent by the reverse titration method. Characterization was carried out through x-ray diffraction analysis (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and N2 adsorption-desorption (Brunauer-Emmett-Teller)...
October 2016: Journal of Chemical Biology
https://www.readbyqxmd.com/read/27698949/influence-of-organic-solvents-on-the-structural-and-thermal-characteristics-of-silk-protein-from-the-web-of-orthaga-exvinacea-hampson-lepidoptera-pyralidae
#8
Sajitha Narayanan, Mankadath Gokuldas
The silk protein from the web of Orthaga exvinacea was isolated, purified, and casted into films. This film was treated separately with methanol, acetone, ethyl acetate, and isopropyl alcohol in 50 % concentration for about 30 min. The treated films were thus dried in a desiccator and subjected to FTIR and TG-DTA analysis. The structural studies revealed that the organic solvents induce conformatory changes in the protein film, especially the most sensitive amide I (1650 cm(-1)) band. This band had shifted to lower wavenumber (1633-1636 cm(-1))...
October 2016: Journal of Chemical Biology
https://www.readbyqxmd.com/read/27698948/structural-insight-into-binding-mode-of-inhibitor-with-sahh-of-plasmodium-and-human-interaction-of-curcumin-with-anti-malarial-drug-targets
#9
Dev Bukhsh Singh, Seema Dwivedi
S-adenosyl-L-homocysteine hydrolase of Plasmodium falciparum (PfSAHH) is a potential drug target against malaria, and selective inhibition of PfSAHH is the excellent strategy to prevent the growth of parasite inside the host. Therefore, a comparative analysis of human S-adenosyl-L-homocysteine hydrolase (HsSAHH) and PfSAHH has been performed to explore the structural differences. Structural superimposition of PfSAHH and HsSAHH has generated the RMSD of 0.749 Å over 394 alpha carbon pairs. Residues of PfSAHH from position Tyr152 to Lys193 aligned with insertion/deletion region in HsSAHH, and these extra residues results in an extent of variation in cavity region of PfSAHH...
October 2016: Journal of Chemical Biology
https://www.readbyqxmd.com/read/27698947/synthesis-of-thiazolidine-2-4-dione-derivatives-anticancer-antimicrobial-and-dna-cleavage-studies
#10
S Vijaya Laxmi, P Anil, G Rajitha, Asha Jyothi Rao, Peter A Crooks, B Rajitha
In the search of efficient anticancer agents, here, new 5-(4-alkylbenzyledene)thiazolidine-2,4-dione derivatives (5a-g) have been successfully synthesized and characterized and are evaluated for anticancer and antimicrobial activities using DNA cleavage studies. In vitro studies on anticancer activity of compound 5d (NSC: 768619/1) was done against the full panel of 60 human tumor cell lines. The five-level dose activity results revealed that, the compound 5d was active against all the cell lines, it has shown potential activity against leukemia SR (GI50: 2...
October 2016: Journal of Chemical Biology
https://www.readbyqxmd.com/read/27493697/jocb-bulletin
#11
(no author information available yet)
No abstract text is available yet for this article.
July 2016: Journal of Chemical Biology
https://www.readbyqxmd.com/read/27493696/synthesis-of-a-series-of-novel-2-5-disubstituted-1-3-4-oxadiazole-derivatives-as-potential-antioxidant-and-antibacterial-agents
#12
M Aruna Sindhe, Yadav D Bodke, R Kenchappa, Sandeep Telkar, A Chandrashekar
A series of novel 2,5-disubstituted-1,3,4-oxadiazole derivatives were synthesized and screened for their antimicrobial and antioxidant activities. The assay indicated that compounds 3c, 3d, and 3i exhibited comparable antibacterial and antioxidant activity with first-line drugs. The structure activity relationship and molecular docking study of the synthesized compounds are also reported.
July 2016: Journal of Chemical Biology
https://www.readbyqxmd.com/read/27493695/homology-modeling-and-virtual-screening-studies-of-fgf-7-protein-a-structure-based-approach-to-design-new-molecules-against-tumor-angiogenesis
#13
Rajender Vadija, Kiran Kumar Mustyala, Navaneetha Nambigari, Ramasree Dulapalli, Rama Krishna Dumpati, Vishwanath Ramatenki, Santhi Prada Vellanki, Uma Vuruputuri
Keratinocyte growth factor (KGF) protein is a member of the fibroblast growth factor (FGF) family, which is also known as FGF-7. The FGF-7 plays an important role in tumor angiogenesis. In the present work, FGF-7 is treated as a potential therapeutic target to prevent angiogenesis in cancerous tissue. Computational techniques are applied to evaluate and validate the 3D structure of FGF-7 protein. The active site region of the FGF-7 protein is identified based on hydrophobicity calculations using CASTp and Q-site Finder active site prediction tools...
July 2016: Journal of Chemical Biology
https://www.readbyqxmd.com/read/27118997/jocb-bulletin
#14
(no author information available yet)
No abstract text is available yet for this article.
April 2016: Journal of Chemical Biology
https://www.readbyqxmd.com/read/27118996/photochemical-synthesis-and-anticancer-activity-of-barbituric-acid-thiobarbituric-acid-thiosemicarbazide-and-isoniazid-linked-to-2-phenyl-indole-derivatives
#15
S Vijaya Laxmi, G Rajitha, B Rajitha, Asha Jyothi Rao
2-Phenyl-1H-indole-3-carbaldehyde-based barbituric acid, thiobarbituric acid, thiosemicarbazide, isoniazid, and malononitrile derivatives were synthesized under photochemical conditions. The antitumor activities of the synthesized compounds were evaluated on three different human cancer cell lines representing prostate cancer cell line DU145, Dwivedi (DWD) cancer cell lines, and breast cancer cell line MCF7. All the screened compounds possessed moderate anticancer activity, and out of all the screened compounds, 5-{1[2-(4-chloro-phenyl)2-oxo-ethyl]-2-phenyl-1H-indole-3-ylmethylene}-2-thioxo-dihydro-pyrimidine-4,6-dione (2b) and 5-{1[2-(4-methoxy-phenyl)2-oxo-ethyl]-2-phenyl-1H-indole-3-ylmethylene}-2-thioxo-dihydro-pyrimidine-4,6-dione (2d) exhibited marked antitumor activity against used cell lines...
April 2016: Journal of Chemical Biology
https://www.readbyqxmd.com/read/26855681/jocb-bulletin
#16
(no author information available yet)
No abstract text is available yet for this article.
January 2016: Journal of Chemical Biology
https://www.readbyqxmd.com/read/26855680/combination-of-sirna-directed-gene-silencing-with-epigallocatechin-3-gallate-egcg-reverses-drug-resistance-in-human-breast-cancer-cells
#17
Mohammad Ali Esmaeili
Elevated expression of NF-E2-related factor 2 (Nrf2), a nuclear transcription factor, is a frequent genetic abnormality seen in this malignancy and is an important contributor to chemoresistance in cancer therapy. In the present study, we investigated if Nrf2 was associated with drug resistance in tamoxifen-resistant MCF-7 (MCF-7/TAM) cells, and whether EGCG, major flavonoid isolated from green tea, could reverse drug resistance in MCF-7/TAM cells. Our results showed that the endogenous expression of Nrf2 as well as its target proteins heme oxygenase-1, NADP (H):quinone oxidoreductase in MCF-7/TAM cells was higher than that in MCF-7 cells...
January 2016: Journal of Chemical Biology
https://www.readbyqxmd.com/read/26855679/synthesis-antibacterial-studies-and-molecular-modeling-studies-of-3-4-dihydropyrimidinone-compounds
#18
Vanitha Ramachandran, Karthiga Arumugasamy, Sanjeev Kumar Singh, Naushad Edayadulla, Penugonda Ramesh, Sathish-Kumar Kamaraj
The syntheses of dihydropyrimidinones (DHPMs) using solvent-free grindstone chemistry method. All the synthesized compounds exhibited significant activity against pathogenic bacteria. The current effort has been developed to obtain new DHPM derivatives that focus on the bacterial ribosomal A site RNA as a drug target. Molecular docking simulation analysis was applied to confirm the target specificity of DHPMs. The crystal structure of bacterial 16S rRNA and human 40S rRNA was taken as receptors for docking...
January 2016: Journal of Chemical Biology
https://www.readbyqxmd.com/read/26855678/theoretical-study-of-electron-transfer-process-between-fullerenes-and-neurotransmitters-acetylcholine-dopamine-serotonin-and-epinephrine-in-nanostructures-neurotransmitters-c-n-complexes
#19
Avat Arman Taherpour, Mohammad Rizehbandi, Fatemeh Jahanian, Ehsan Naghibi, Nosrat-Allah Mahdizadeh
Neurotransmitters are the compounds which allow the transmission of signals from one neuron to the next across synapses. They are the brain chemicals that communicate information throughout brain and body. Fullerenes are a family of carbonallotropes, molecules composed entirely of carbon, that take the forms of spheres, ellipsoids, and cylinders. Various empty carbon fullerenes (Cn) with different carbon atoms have been obtained and investigated. Topological indices have been successfully used to construct effective and useful mathematical methods to establish clear relationships between structural data and the physical properties of these materials...
January 2016: Journal of Chemical Biology
https://www.readbyqxmd.com/read/26855677/an-initial-top-down-proteomic-analysis-of-the-standard-cuprizone-mouse-model-of-multiple-sclerosis
#20
Melissa A Partridge, Sumana Gopinath, Simon J Myers, Jens R Coorssen
An initial proteomic analysis of the cuprizone mouse model to characterise the breadth of toxicity by assessing cortex, skeletal muscle, spleen and peripheral blood mononuclear cells. Cuprizone treated vs. control mice for an initial characterisation. Select tissues from each group were pooled, analysed in triplicate using two-dimensional gel electrophoresis (2DE) and deep imaging and altered protein species identified using liquid chromatography tandem mass spectrometry (LC/MS/MS). Forty-three proteins were found to be uniquely detectable or undetectable in the cuprizone treatment group across the tissues analysed...
January 2016: Journal of Chemical Biology
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