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Iranian Journal of Kidney Diseases

Abdolmohammad Ranjbar, Mohammad Reza Ardalan
No abstract text is available yet for this article.
July 2018: Iranian Journal of Kidney Diseases
Mehdi Esmaeili Jadidi, Farshid Oliaei
Urinary tract anomalies are common and comprise about 20% to 30% of total congenital anomalies. This spectrum consists of many different anomalies of the urinary tract that may be syndromic or nonsyndromic with different etiologies. In this case report, a patient with single kidney and urinary tract signs is introduced that was diagnosed accidentally. The finding of different anomalies in different organ systems should lead us to examination of the intactness of the urinary tract. In these disorders, if there is no need for immediate intervention, long-term follow-up can be helpful to postpone chronic kidney disease progression...
July 2018: Iranian Journal of Kidney Diseases
Shen-Ju Gou, Shao-Bin Yu, Hong-Yu Qiu, Zhang-Xue Hu
Awareness of the uncommon associated clinical manifestations of immunoglobulin G4 (IgG4)-related kidney disease is essential for the early diagnosis and effective treatment of patients. To the best of our knowledge, there have been few reports of patients with IgG4-related kidney disease associated with autoimmune hemolytic anemia. We here report a rare case of IgG4-related kidney disease associated with autoimmune hemolytic anemia. A 70-year-old man with kidney dysfunction and severe anemia had been diagnosed with chronic kidney disease and treated without any improvement...
July 2018: Iranian Journal of Kidney Diseases
Sofia Hussain, Naureen Akhtar, Reem Qamar, Naima Khan, Muhammad Naeem
Nephronophthisis is an autosomal recessive cystic kidney disease characterized by tubular interstitial infiltration, periglomerular fibrosis, and cysts, and is the most frequent genetic cause of end-stage renal disease in children. Nephronophthisis is pleiotropic as almost all the causative genes are involved in primary cilium and centrosome function which are found in almost all human cells. Genetic heterogeneity in nephronophthisis makes the molecular and genetic diagnosis somewhat difficult. Homozygous deletions in the nephronophthisis 1 (NPHP1) gene are the major contributor of nephronophthisis cases, while other genes accounts for less than 3% each...
July 2018: Iranian Journal of Kidney Diseases
Lihua Wang, Lan Jia, Fang Wei, Zhi Lu, Bo Wang, Hongye Dong, Guijiang Sun, Haibo Yu, Ruining Zhang, Aili Jiang
INTRODUCTION: Many studies have reported increased intimal thickness around the catheter tip after catheterization. Caveolin-1 is a protein in the endothelial cell that acts as a shear sensor causing vascular remodeling. This study aimed to elucidate the suitability of different catheter locations and determine the role of caveolin-1 in canine models. MATERIALS AND METHODS: Tunneled silicone 14.5-F catheters were inserted into the left jugular vein and right femoral vein in 8 dogs...
July 2018: Iranian Journal of Kidney Diseases
Cleber Machado-Souza, Ana Paula Ribeiro Braosi, Sônia Mara Luczyszyn, Marcia Olandoski, Miguel Carlos Riella, Paula Cristina Trevilatto, Roberto Pecoits-Filho
INTRODUCTION: The vitamin D-receptor axis is involved in multiple physiological functions and altered states such as hypertension, mineral metabolism disorders, and inflammation. These disturbances are major risk factors for progression to end-stage kidney disease and cardiovascular disease. In addition, changes in internal systemic environment could be influencing the impact of survival in patients with kidney disease. This study aimed to evaluate the impact of vitamin D receptor (VDR) polymorphisms on hemodialysis patients' survival...
July 2018: Iranian Journal of Kidney Diseases
Maryam Mirfatahi, Hossein Imani, Hadi Tabibi, Alireza Nasrollahi, Mehdi Hedayati
INTRODUCTION: Chronic kidney disease-mineral and bone disorder is a common complication in hemodialysis patients. The present study was designed to investigate the effects of flaxseed oil, a rich source of plant omega-3 fatty acid alpha-linolenic acid, on serum markers of bone formation and resorption in hemodialysis patients. MATERIALS AND METHODS: In this randomized controlled trial, 34 hemodialysis patients were randomly assigned to either the flaxseed oil or the control group...
July 2018: Iranian Journal of Kidney Diseases
Mitra Samareh Fekri, Abbas Etminan, Alireza Rashidnedjad, Aboozar Mojibian, Yaser Masoomi
INTRODUCTION: Pulmonary arterial hypertension (PAH) is a destructive disease that is characterized by vasoconstriction, alterations and abnormal angiogenesis in pulmonary vessels, and right ventricular dysfunction. There is no certain treatment known for this condition. Patients with PAH have a lower level of apelin in their blood and less apelin is secreted in their endothelial cells, but this condition is not investigated in hemodialysis patients. This study aimed to compare apelin level in hemodialysis patients with and without PAH...
July 2018: Iranian Journal of Kidney Diseases
Zahra Yari, Parvin Mirmiran
Chronic kidney disease is defined as a glomerular filtration rate lower than 60 mL/min/1.73 m2, which is regarded as a public health priority and part of the growing burden of noncommunicable diseases. Reduced kidney function is concomitant with high levels of inflammatory factors, abnormal lipid profile, and anemia, as well as bone abnormalities, calcium deposition outside the bones, endothelial dysfunction, and cardiomyopathy. Furthermore, metabolic acidosis is a common complication in chronic kidney disease that is associated with secondary hyperparathyroidism and faster kidney disease progression...
July 2018: Iranian Journal of Kidney Diseases
Leila Malekmakan, Taraneh Tadayon, Jamshid Roozbeh, Mehrab Sayadi
INTRODUCTION: End-stage renal disease (ESRD) results in unpleasant consequences for patients, their families, and also society. Annually, each country expends a huge amount for ESRD treatment. In addition, its prevalence is dramatically growing, though it can be prevented. Many countries do not have accurate epidemiologic data about this disease. We conducted this study to measure a pooled prevalence of ESRD in the Middle East. MATERIALS AND METHODS: Included articles were prospective and retrospective cross-sectional and editorial studies from January 1990 till January 2015 from the Middle East area that reported the prevalence of ESRD and renal replacement therapy...
July 2018: Iranian Journal of Kidney Diseases
Sora Yasri, Viroj Wiwanitkit
No abstract text is available yet for this article.
May 2018: Iranian Journal of Kidney Diseases
Kourosh Goudarzipour, Farzaneh Farahmandi, Ahmad Mohammadi, Reza Taherian
Ewing sarcoma/peripheral primitive neuroectodermal tumor (ES/PNET) typically occurs in long or flat bones, soft tissues, or less often, solid organs. Ewing sarcoma/peripheral primitive neuroectodermal tumor arising from the adrenal gland is extremely rare, especially in children, and only limited cases are reported previously. Herein, we review a case of a 22-month-old girl who presented to our department with abdominal pain, bulging of the left flank, and a nonfunctioning adrenal lesion which was found to be an adrenal ES/PNET...
May 2018: Iranian Journal of Kidney Diseases
Amir Ahmad Nassiri, Legha Lotfollahi, Neda Behzadnia, Ilad Alavi Darazam, Monir Sadat Hakemi, Azam Rahimzadeh Kalaleh, Monir Kamalkhani
INTRODUCTION: Systemic arterial hypertension is prevalent in end-stage renal disease and is closely associated with left ventricular hypertrophy (LVH). Blood pressure (BP) behavior is unique in this population, and it is not clear which BP measurement should be used for treatment guidance. We aimed to evaluate the association of several methods of BP measurement with left ventricular mass index (LVMI) as hypertensive end-organ damage. MATERIALS AND METHODS: Patients on maintenance hemodialysis, 3 or 4 times per week for at least 3 months, were enrolled...
May 2018: Iranian Journal of Kidney Diseases
Xiaoxue Zhang, Ying Chen, Yamei Cai, Xing Tian, Jing Xiao, Zhanzheng Zhao, Dahai Yu
INTRODUCTION: This study aimed to assess the number and profiles of patients initializing peritoneal dialysis form the Henan Peritoneal Dialysis Registry, a provincial database in central China. MATERIALS AND METHODS: All patients aged 18 years and greater, initializing peritoneal dialysis within the province during 2007 to 2014 were included. Demographic characteristics were collected and clinical parameters included the type of renal diagnosis (primary glomerular, secondary glomerular, and others) and recorded major comorbidities in the neural, cardiovascular, respiratory, gastrointestinal, and endocrine systems...
May 2018: Iranian Journal of Kidney Diseases
Alaleh Gheissari, Rokhsareh Meamar, Amin Abedini, Peyman Roomizadeh, Mohammad Shafiei, Zahra Samaninobandegani, Zhale Tabrizi, Farhad Mahmoudi, Alireza Merrikhi, Esfandiar Najafi Tavana
INTRODUCTION: Cardiovascular disease (CVD) is the main cause of death in children with end-stage renal disease (ESRD). Matrix metalloproteinases (MMP-2 and MMP-9) are members of endopeptidases which contribute to CVD. The aim of this study was to evaluate the association of MMP-2 and MMP-9 with markers of endothelial dysfunction, soluble E-selectin and brachial flow-mediated dilatation; several biochemical risk factors of CVD; and thrombotic incidents in children with ESRD. MATERIALS AND METHODS: Thirty-one children with ESRD and 18 healthy age- and sex-adjusted controls underwent measurement of serum levels of MMP-2, MMP-9, soluble E-selectin, phosphorus, calcium, parathyroid hormone, lipid profile, thrombotic factors, and albumin...
May 2018: Iranian Journal of Kidney Diseases
Naghmeh Akbarian, Nosratollah Zarghami, Ali Mota, Sima Abediazar, Sina Abroon, Aynaz Mihanfar, Mina Amanzadeh, Akbar Darbin, Hossein Bannazadeh Baghi, Mohammad Rahmati-Yamchi
INTRODUCTION: Diabetic nephropathy is one of the serious complications of diabetes mellitus. Visfatin is an intracellular enzyme with insulin-mimicking effects. It enhances the expression of endothelial nitric oxide (NO) synthase in renal cells. This study aimed to investigate serum levels of visfatin and NO metabolites in patients with diabetic nephropathy. MATERIALS AND METHODS: A total of 80 diabetic patients were enrolled and classified into nephropathic and non-nephropathic patients...
May 2018: Iranian Journal of Kidney Diseases
Esmat Aghadavod, Alireza Soleimani, Gholamali Hamidi, Fariba Keneshlou, Akbar Heidari, Zatollah Asemi
INTRODUCTION: Patients with diabetic nephropathy (DN) may benefit from vitamin E's antilipid and antioxidant activities. This study aimed to evaluate the effects of high-dose vitamin E supplementation on markers of cardiometabolic risk and oxidative stress in patients with DN. MATERIALS AND METHODS: This randomized controlled trial was carried out on 54 patients with DN that were randomly divided into 2 groups to receive vitamin E supplement (800 IU/d) or placebo for 12 weeks...
May 2018: Iranian Journal of Kidney Diseases
Ayse Feyda Nursal, Ercan Turkmen, Suheyla Uzun Kaya, Akin Tekcan, Ozlem Sezer, Sumeyya Deniz Celik, Serbulent Yigit
INTRODUCTION: The most important complication of familial Mediterranean fever (FMF) is secondary amyloidosis, which can lead to kidney failure. Genetic variability in the genes of various components of the renin-angiotensin system may play a role in the pathogenesis of the kidney disorders.  The aim of the present study was to investigate the association between angiotensin converting enzyme (ACE) gene I/D variant and risk of developing FMF-related amyloidosis in Turkish patients. MATERIALS AND METHODS: A total of 240 individuals consisting of 40 patients with FMF-related amyloidosis, 100 FMF patients without amyloidosis, and 100 healthy controls were recruited...
May 2018: Iranian Journal of Kidney Diseases
Mahdieh Salimi, Sepehr Sarrafzadeh Zargar
INTRODUCTION: The initiation and progression of diabetic nephropathy (DN) is complex. Quantification of mRNA expression in urinary sediment cells (USCs) has emerged as a novel strategy for studying kidney diseases. Insulin requires a family of insulin receptor substrate (IRS) proteins for its physiological effects, and many reports have highlighted the role of insulin and IRS proteins in kidney physiology and disease. This study aimed to assess IRS2 expression in USCs of patients with diabetes mellitus, DN, and nondiabetic chronic kidney disease...
May 2018: Iranian Journal of Kidney Diseases
Fariba Samadian, Nooshin Dalili, Leila Mahmoudieh, Shadi Ziaei
The administration of radiocontrast media may lead to kidney injury, known as contrast-induced nephropathy, which is reversible in most cases, but its development may be associated with adverse outcomes. This review article provides recommendations for the prevention of contrast nephropathy.
May 2018: Iranian Journal of Kidney Diseases
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