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Iranian Journal of Kidney Diseases

Hatice Sahin, Ebru Gok Oguz, Hadim Akoglu, Gokhan Atilgan, Gulay Ulusal Okyay, Guner Karaveli Gursoy, Tugba Kip Teymur, Dilek Ertoy, Basol Canbakan, Mehmet Deniz Ayli
Two-thirds of complement C3 glomerulopathy (C3G) recur after transplantation and commonly cause graft loss. There is not a standard treatment protocol for these cases. We present a kidney transplant patient with recurrent C3G who was successfully treated with eculizumab. Nephrotic proteinuria and hematuria occurred and creatinine levels increased after transplantation. A graft biopsy revealed recurrent C3G. The patient was administered 250 mg pulse methylprednisolone for 3 days and had 9 sessions of plasmapheresis...
October 2018: Iranian Journal of Kidney Diseases
Sara Abolghasemi, Fatemeh Abbasi, Shabnam Tehrani, Mohsen Nafar, Mohammad Javad Nasiri
Mycobacterium haemophilum is a fastidious nontuberculosis Mycobacterium that must be considered in the differential diagnosis of infections in immunocompromised patients. Mycobacterium haemophilum typically is a pathogen of the cutaneous or subcutaneous tissue and also presents as septic arthritis, osteomyelitis, pulmonary disease, and lymphadenitis. We report a 32-year-old man with past medical history of kidney transplantation, endocarditis, gastrointestinal bleeding, and hypertension, complaining of multiple painful nodular lesions since 3 months earlier...
October 2018: Iranian Journal of Kidney Diseases
Zubair Khuja, Manzoor Parry, Roohi Rasool, Abdul Rashid Reshi
INTRODUCTION: The forkhead box P3 (FOXP3) gene is important for regulation and development of T cells, which are mediators of kidney allograft rejection. The FOXP3 gene polymorphism may be associated with the rejection of kidney transplants. This study was designed to determine the association of FOXP3 polymorphism with kidney transplant rejection. MATERIALS AND METHODS: A total of 118 kidney transplant patients were included in this study and were grouped into rejection (n = 31) and nonrejection (n = 87) groups...
October 2018: Iranian Journal of Kidney Diseases
Gokhan Cakirca, Faruk Hilmi Turgut
INTRODUCTION: This study was aimed to investigate the efficacy of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), and the neutrophil gelatinase-associated lipocalin (NGAL)-bound form of MMP-9 (MMP-9/NGAL complex) markers in the determination of early nephropathy in patients with type 2 diabetes mellitus. MATERIALS AND METHODS: Twenty-five type 2 diabetic patients with normoalbuminuria, 27 type 2 diabetic patients with microalbuminuria, and 23 healthy controls were recruited...
October 2018: Iranian Journal of Kidney Diseases
Mohamed N El-Gamasy, Walid Ahmed El-Shehaby
INTRODUCTION: Acute nephritic syndrome (ANS) is the most common cause of hypertensive heart failure in pediatric population. There are few publications on myocardial evaluation using electrocardiographic and echocardiographic data in pediatric patients with ANS. This study aimed to evaluate myocardial function by electrocardiography and 2-dimensional echocardiography in Egyptian pediatric patients with ANS. MATERIALS AND METHODS: Sixty children with ANS were included and subjected to clinical, laboratory, electrocardiography for corrected QT interval, and 2-dimensional echocardiographic study on admission, and repeated at 6 and 12 weeks to measure left ventricular ejection fraction, left atrium-aorta ratio, and the ratio of peak early filling (E wave) to late diastolic filling (A wave) velocities (E/A ratio)...
October 2018: Iranian Journal of Kidney Diseases
Leyla Gadakchi, Mehrzad Hajialilo, Mohammad-Reza Nakhjavani, Sima Abedi Azar, Sousan Kolahi, Morteza Gojazadeh, Ali-Asghar Ebrahimi, Aida Malek Mahdavi, Hamid Noshad, Alireza Khabbazi
INTRODUCTION: Lupus nephritis is a common and severe manifestation of systemic lupus erythematosus that can lead to end-stage renal disease and death. The aim of this study was to compare the efficacy and safety of mycophenolate mofetil (MMF) and cyclophosphamide as induction therapy and subsequently as maintenance therapy for lupus nephritis. MATERIALS AND METHODS: In this retrospective case-control study, 67 patients with proliferative lupus nephritis who were treated with MMF (n = 45) and pulse of intravenous cyclophosphamide (n = 22) were included...
October 2018: Iranian Journal of Kidney Diseases
Zahra Golmohamadi, Hassan Argani, Amir Ghorbanihaghjo, Nadereh Rashtchizadeh, Nasrin Bargahi, Mehran Mesgari, Davoud Sanajou
INTRODUCTION: Nontraditional risk factors for cardiovascular disease (CVD), including mineral disorder, high fibroblast growth factor 23 (FGF23), low klotho, and low soluble TWEAK could predict the incipient risk of CVD in chronic kidney disease (CKD). The present study evaluates the effect of sevelamer on soluble tumor necrosis factor-like weak inducer of apoptosis (TWEAK), and klotho levels in adenine-induced CKD rats. METHODS AND MATERIALS: Normal control rats without sevelamer were compared with 3 groups of adenine-induced CKD rats, including CKD rats without sevelamer, CKD rats treated with 3% sevelamer, and rats receiving adenine and 3% sevelamer concurrently...
October 2018: Iranian Journal of Kidney Diseases
Seçil Conkar, Sevgi Mir, Eser Dogan, Zulal Ülger Tutar
INTRODUCTION: It is known that in children with chronic kidney disease (CKD), cardiovascular damage starts in the form of arterial stiffness. There are risk factors other than the traditional ones such as arterial stiffness hypertension, obesity, hypercholesterolemia, and insulin resistance. Vitamin D deficiency is rather common in CKD, and it was introduced as a risk factor for atherosclerosis; however, its relationship with arterial stiffness is not known completely. The purpose of this study was to research the relationship between 25-hydroxyvitamin D levels and arterial stiffness...
October 2018: Iranian Journal of Kidney Diseases
Halle Marie Patrice, Oumarou Moussa, Kaze Francois, Mapoure Yacouba, Mbatchou Hugo, Luma Henry
INTRODUCTION: Chronic kidney disease (CKD) is frequent amongst human immunodeficiency virus (HIV)-positive patients, and screening is not routinely performed in Sub-Saharan Africa due to resource constraints. We aimed to determine the prevalence of CKD and associated factors in HIV-infected patients in Cameroon. MATERIALS AND METHODS: A cross-sectional study in Northern Cameroon included HIV-positive patients who attended the HIV clinic. Patients with an estimated glomerular filtration rate less than 60 mL/min/1...
October 2018: Iranian Journal of Kidney Diseases
Nooshin Dalili, Kianoush Kashani
Acute kidney injury is a very common complication of acute illnesses with dire consequences. There are significant differences in incidence, etiology, severity, and clinical impact of acute kidney injury between resource-sufficient and resource-limited regions. Awareness of such differences would potentially allow clinicians and policymakers to devise and provide region-specific interventions to decrease the incidence of acute kidney injury and mitigate its complications. In this review article, we describe the similarities and differences of acute kidney injury risk factors and risk stratifications based on the level of resource availability in different regions...
October 2018: Iranian Journal of Kidney Diseases
Dorna Davani-Davari, Iman Karimzadeh, Shahrokh Ezzatzadegan-Jahromi, Mohammad Mahdi Sagheb
INTRODUCTION: Nowadays, creatine is one of the most common oral supplements used by professional athletes for boosting their strength and muscle mass. In this review, we collect available experimental and clinical data about renal safety of both short-term and long-term use of creatine. MATERIALS AND METHODS: Scientific literature was critically searched by keywords "creatine," "renal insufficiency," and "renal dysfunction" and their synonyms in medical databases (Scopus, MEDLINE, EMBase, and ISI Web of Knowledge)...
October 2018: Iranian Journal of Kidney Diseases
Abdolmohammad Ranjbar, Mohammad Reza Ardalan
No abstract text is available yet for this article.
July 2018: Iranian Journal of Kidney Diseases
Mehdi Esmaeili Jadidi, Farshid Oliaei
Urinary tract anomalies are common and comprise about 20% to 30% of total congenital anomalies. This spectrum consists of many different anomalies of the urinary tract that may be syndromic or nonsyndromic with different etiologies. In this case report, a patient with single kidney and urinary tract signs is introduced that was diagnosed accidentally. The finding of different anomalies in different organ systems should lead us to examination of the intactness of the urinary tract. In these disorders, if there is no need for immediate intervention, long-term follow-up can be helpful to postpone chronic kidney disease progression...
July 2018: Iranian Journal of Kidney Diseases
Shen-Ju Gou, Shao-Bin Yu, Hong-Yu Qiu, Zhang-Xue Hu
Awareness of the uncommon associated clinical manifestations of immunoglobulin G4 (IgG4)-related kidney disease is essential for the early diagnosis and effective treatment of patients. To the best of our knowledge, there have been few reports of patients with IgG4-related kidney disease associated with autoimmune hemolytic anemia. We here report a rare case of IgG4-related kidney disease associated with autoimmune hemolytic anemia. A 70-year-old man with kidney dysfunction and severe anemia had been diagnosed with chronic kidney disease and treated without any improvement...
July 2018: Iranian Journal of Kidney Diseases
Sofia Hussain, Naureen Akhtar, Reem Qamar, Naima Khan, Muhammad Naeem
Nephronophthisis is an autosomal recessive cystic kidney disease characterized by tubular interstitial infiltration, periglomerular fibrosis, and cysts, and is the most frequent genetic cause of end-stage renal disease in children. Nephronophthisis is pleiotropic as almost all the causative genes are involved in primary cilium and centrosome function which are found in almost all human cells. Genetic heterogeneity in nephronophthisis makes the molecular and genetic diagnosis somewhat difficult. Homozygous deletions in the nephronophthisis 1 (NPHP1) gene are the major contributor of nephronophthisis cases, while other genes accounts for less than 3% each...
July 2018: Iranian Journal of Kidney Diseases
Lihua Wang, Lan Jia, Fang Wei, Zhi Lu, Bo Wang, Hongye Dong, Guijiang Sun, Haibo Yu, Ruining Zhang, Aili Jiang
INTRODUCTION: Many studies have reported increased intimal thickness around the catheter tip after catheterization. Caveolin-1 is a protein in the endothelial cell that acts as a shear sensor causing vascular remodeling. This study aimed to elucidate the suitability of different catheter locations and determine the role of caveolin-1 in canine models. MATERIALS AND METHODS: Tunneled silicone 14.5-F catheters were inserted into the left jugular vein and right femoral vein in 8 dogs...
July 2018: Iranian Journal of Kidney Diseases
Cleber Machado-Souza, Ana Paula Ribeiro Braosi, Sônia Mara Luczyszyn, Marcia Olandoski, Miguel Carlos Riella, Paula Cristina Trevilatto, Roberto Pecoits-Filho
INTRODUCTION: The vitamin D-receptor axis is involved in multiple physiological functions and altered states such as hypertension, mineral metabolism disorders, and inflammation. These disturbances are major risk factors for progression to end-stage kidney disease and cardiovascular disease. In addition, changes in internal systemic environment could be influencing the impact of survival in patients with kidney disease. This study aimed to evaluate the impact of vitamin D receptor (VDR) polymorphisms on hemodialysis patients' survival...
July 2018: Iranian Journal of Kidney Diseases
Maryam Mirfatahi, Hossein Imani, Hadi Tabibi, Alireza Nasrollahi, Mehdi Hedayati
INTRODUCTION: Chronic kidney disease-mineral and bone disorder is a common complication in hemodialysis patients. The present study was designed to investigate the effects of flaxseed oil, a rich source of plant omega-3 fatty acid alpha-linolenic acid, on serum markers of bone formation and resorption in hemodialysis patients. MATERIALS AND METHODS: In this randomized controlled trial, 34 hemodialysis patients were randomly assigned to either the flaxseed oil or the control group...
July 2018: Iranian Journal of Kidney Diseases
Mitra Samareh Fekri, Abbas Etminan, Alireza Rashidnedjad, Aboozar Mojibian, Yaser Masoomi
INTRODUCTION: Pulmonary arterial hypertension (PAH) is a destructive disease that is characterized by vasoconstriction, alterations and abnormal angiogenesis in pulmonary vessels, and right ventricular dysfunction. There is no certain treatment known for this condition. Patients with PAH have a lower level of apelin in their blood and less apelin is secreted in their endothelial cells, but this condition is not investigated in hemodialysis patients. This study aimed to compare apelin level in hemodialysis patients with and without PAH...
July 2018: Iranian Journal of Kidney Diseases
Zahra Yari, Parvin Mirmiran
Chronic kidney disease is defined as a glomerular filtration rate lower than 60 mL/min/1.73 m2, which is regarded as a public health priority and part of the growing burden of noncommunicable diseases. Reduced kidney function is concomitant with high levels of inflammatory factors, abnormal lipid profile, and anemia, as well as bone abnormalities, calcium deposition outside the bones, endothelial dysfunction, and cardiomyopathy. Furthermore, metabolic acidosis is a common complication in chronic kidney disease that is associated with secondary hyperparathyroidism and faster kidney disease progression...
July 2018: Iranian Journal of Kidney Diseases
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