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Iranian Journal of Kidney Diseases

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https://www.readbyqxmd.com/read/29421779/nephropathic-cystinosis-mimicking-bartter-syndrome-a-novel-mutation
#1
Funda Bastug, Hulya Nalcacioglu, Fatih Ozaltin, Emine Korkmaz, Sibel Yel
Cystinosis is a rare autosomal recessive disorder resulting from defective lysosomal transport of cystine due to mutations in the cystinosin lysosomal cystine transporter (CTNS) gene. The clinical phenotype of nephropathic cystinosis is characterized by renal tubular Fanconi syndrome and development of end-stage renal disease during the first decade. Although metabolic acidosis is the classically prominent finding of the disease, a few cases may present with hypokalemic metabolic alkalosis mimicking Bartter syndrome...
January 2018: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29421778/prevalence-of-sarcopenia-and-dynapenia-and-their-determinants-in-iranian-peritoneal-dialysis-patients
#2
Atefeh As'habi, Iraj Najafi, Hadi Tabibi, Mehdi Hedayati
INTRODUCTION: Uremic sarcopenia and dynapenia are prevalent in chronic kidney disease patients, including dialysis patients. The present study was designed to determine the prevalence of sarcopenia and dynapenia and their determinants in peritoneal dialysis (PD) patients in Tehran, Iran. MATERIALS AND METHODS: All eligible PD patients at the peritoneal dialysis centers of Tehran were included in this cross-sectional study. Skeletal muscle mass and muscle strength were assessed using bioelectrical impedance analysis and hand grip strength, respectively...
January 2018: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29421777/effect-of-hemodialysis-on-global-and-regional-cardiac-function-in-children-with-end-stage-renal-disease
#3
Hamid Amoozgar, Amir Naghshzan, Mitra Basiratnia, Maryam Ahmadipoor
INTRODUCTION: Changes in cardiac structure and function are common among patients with end-stage renal disease. The aim of this study was to evaluate the effect of hemodialysis on global and segmental cardiac function in children with end-stage renal disease. MATERIALS AND METHODS: Fifty-two children with ESRD who were on long-term hemodialysis at Nemazee Hospital, Shiraz, were enrolled. They underwent echocardiography (M-mode, 2-dimensional, Doppler, and speckle echocardiography) 30 minutes prior to and after hemodialysis, and the values were compared...
January 2018: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29421776/association-between-matrix-metalloproteinase-3-activity-and-glomerular-filtration-rate-and-albuminuria-status-in-patients-with-type-2-diabetes-mellitus
#4
Mina Amanzadeh, Ali Mota, Nosratollah Zarghami, Sima Abedi-Azar, Sina Abroon, Naghmeh Akbarian, Aynaz Mihanfar, Mohammad Rahmati-Yamchi
INTRODUCTION: Diabetic nephropathy is pictured as matrix accumulation and thickening of glomerular basal membrane. Matrix metalloproteinases (MMPs) are major proteases involved in extracellular matrix degradation. Moreover, plasminogen activator inhibitor-1 (PAI-1) primarily regulates plasmin dependent proteolysis. It plays a role in renal fibrosis causing extracellular matrix accumulation through inhibition of plasmin-dependent extracellular matrix degradation. This study investigated PAI-1 serum level and MMP-3 activity and their correlation with glomerular filtration rate in patients with diabetes mellitus...
January 2018: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29421775/increased-urine-interleukin-17-and-interleukin-22-levels-in-patients-with-candidal-urinary-tract-infection
#5
Kazem Ahmadikia, Parivash Kordbacheh, Pejman Shadpour, Sanam Nami, Abdolfattah Sarrafnejad, Mahmood Mahmoodi, Mahin Safara, Mohsen Rokni, Mohammad Yarahmadi, Shahram Mahmoudi, Mahdis Khezri, Farideh Zaini
INTRODUCTION: Candiduria is common in the hospitalized patients. This study aimed to quantify interleukin (IL)-17 and IL-22 levels in urine of candiduric patients. MATERIALS AND METHODS: A case-control study was conducted on inpatients at Hashemi Nejad Kidney Center. Thirty-four patients were identified with Candida species in their urine samples (> 103 colony-forming units per milliliter and presence of Candida species only). Urine samples with concomitant infections were excluded...
January 2018: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29421774/efficacy-and-safety-of-rituximab-in-children-with-steroid-and-cyclosporine-resistant-and-steroid-and-cyclosporine-dependent-nephrotic-syndrome
#6
Rozita Hoseini, Kamran Sabzian, Hasan Otukesh, Nazanin Zafaranloo, Parsa Panahi, Nahid Rahimzadeh, Shahrbanoo Nakhaie, Mohsen Akhavan Sepehi
INTRODUCTION: There is evidence of the effectiveness of rituximab in treatment of nephrotic syndrome in children. The present study aimed to assess safety and the therapeutic effectiveness of rituximab in steroid- and cyclosporine-resistant pediatric nephrotic syndrome. MATERIALS AND METHODS: Forty-three children with steroid- and cyclosporine-resistant or steroid- and cyclosporine-dependent noncongenital nephrotic syndrome were included in the study to receive intravenous rituximab, 375 mg/m2/wk, for 4 weeks...
January 2018: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29421773/study-of-urine-composition-of-patients-with-recurrent-nephrolithiasis-in-lorestan-iran
#7
Babak Hadian, Azita Zafar-Mohtashami, Fershteh Ghorbani
INTRODUCTION: Nephrolithiasis is one of the most common urinary tract diseases. After the first episode of urinary calculus, the risk of recurrence is nearly 40% to 50% at 5 years. Nephrolithiasis is a systemic disease that is associated with some metabolic disorders. This study aimed to provide a picture of the frequency of metabolic abnormalities in patients with nephrolithiasis from west part of Iran. MATERIALS AND METHODS: Patients with recurrent urinary tract calculi referred to the Nephrology-Urology Clinics in Khorramabad city were recruited...
January 2018: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29421772/effects-of-coenzyme-q10-supplementation-on-gene-expressions-related-to-insulin-lipid-and-inflammation-pathways-in-patients-with-diabetic-nephropathy
#8
Akbar Heidari, Gholamali Hamidi, Alireza Soleimani, Esmat Aghadavod, Zatollah Asemi
INTRODUCTION: Data on the effects of coenzyme Q10 (CQ10) on gene expression related to insulin, lipid, and inflammation in patients with diabetic nephropathy (DN) are scarce. This study aimed to determine the effects of CQ10 supplementation on gene expression related to insulin, lipid, and inflammation pathways in patients with DN. MATERIALS AND METHODS: Forty patients with DN, aged 40 to 85 years old, were randomly assigned into 2 groups to receive either 100 mg/d of CQ10 supplements (n = 20) or placebo (n = 20), for 12 weeks...
January 2018: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29421771/serum-beta-trace-protein-for-assessment-of-kidney-function-in-neonates
#9
Nastaran Khosravi, Manoochehr Asgari, Nasrin Khalessi, Rozita Hoseini, Niloofar Khosravi
INTRODUCTION: Compared to the conventional methods, serum beta-trace protein (BTP) has been shown to be more helpful for estimating glomerular filtration rate; however, its value is remained unclear in neonates. The present study aimed to investigate the range of serum BTP level in healthy term neonates and its value to estimate glomerular filtration rate. MATERIALS AND METHODS: This cross-sectional study was conducted on 50 healthy term neonates without underlying cardiovascular or kidney disorders who were admitted to Ali Asghar hospital in 2013...
January 2018: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29421770/cystitis-cystica-glandularis-radiological-imitator-of-urothelial-carcinoma
#10
Binit Sureka, Vikas Jain, Saurabh Jain, Archana Rastogi
No abstract text is available yet for this article.
January 2018: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29421769/hepatitis-b-virus-infection-in-iranian-hemodialysis-patients-a-systematic-review-and-meta-analysis
#11
Shirin Djalalinia, Nahid Ramezan Ghorbani, Ramin Tajbakhsh, Mitra Modirian, Zahra Esmaeili Abdar, Armita Mahdavi Gorabi, Morteza Mansourian, Mehrdad Kazemzadeh Atoofi, Hamid Asayesh, Saeid Safiri, Mehdi Noroozi, Mostafa Qorbani
INTRODUCTION: Hepatitis B virus (HBV) infection in hemodialysis patients and its associated adverse health consequences are a worldwide health priority. This systematic review aimed to provide evidence on HBV infection in Iranian hemodialysis patients. MATERIALS AND METHODS: Through a comprehensive systematic review of literature, which led to meta-analysis of findings, we estimated the pooled prevalence of HBV infection in Iranian hemodialysis patients. The main international electronic data sources were MEDLINE, Institute of Scientific Information, and Scopus...
January 2018: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29190609/nephroquiz-10-a-16-year-old-patient-with-thrombocytopenia-and-kidney-failure
#12
Maryam Ghazizadeh, Matin Ghazizadeh, Mohsen Nafar
No abstract text is available yet for this article.
November 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29190608/seropositivity-of-rheumatoid-arthritis-specific-tests-in-a-patient-with-nephrotic-syndrome-successful-treatment-with-rituximab
#13
Alireza Mirzaei, Yousef Ataeipoor, Mojgan Asgari, Mozhdeh Zabihiyeganeh
Presentation of rheumatoid arthritis (RA) with renal complications is very rare without articular symptoms. We here report a case of a 23-year-old woman, presenting with the edema of the extremities, no relevant previous medical history, and the features of acute tubular injury in her percutaneous kidney biopsy. Following the incidental notification of a positive rheumatoid factor test, other immunologic tests including anticyclic citrullinated peptide and antimutated citrullinated vimentin were performed, the positive results of which favored the diagnosis of RA...
November 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29190607/effect-of-paricalcitol-on-bone-density-after-kidney-transplantation-analysis-of-2-transplant-centers
#14
Zuzana Žilinská, Ivana Dedinská, Ján Breza, Ludovít Laca
INTRODUCTION: The Kidney Disease: Improving Global Outcomes Clinical Practice Guidelines on the management of bone disease in patients with chronic kidney disease recommend periodic measurement of serum calcium, phosphorus, vitamin D, and parathyroid hormone levels after kidney transplantation, with the frequencies that will vary according to the severity of bone disease and graft function. Paricalcitol, a selective vitamin D receptor activator, is indicated in the prevention and treatment of secondary hyperparathyroidism...
November 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29190606/association-between-klotho-gene-polymorphism-and-markers-of-bone-metabolism-in-patients-receiving-maintenance-hemodialysis-in-iran
#15
Aboalfazl Nazarian, Meisam Hasankhani, Monireh Aghajany-Nasab, Ali Monfared
INTRODUCTION: Some genetic variations of Klotho have been reported as a risk factor for calcification and hyperphosphatemia in chronic kidney disease. Klotho polymorphism is also associated with outcome in patients receiving hemodialysis. This study aimed to evaluate the relationship between Klotho single nucleotide polymorphism (SNP) and bone metabolism as an early prognostic measure for chronic kidney disease.   Materials and Methods. Sixty patients receiving hemodialysis and 60 age-matched controls were enrolled in the study of the assessment of 2 types of Klotho polymorphism (G395A and C1818T)...
November 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29190605/evaluation-of-renal-toxicity-of-colistin-therapy-with-neutrophil-gelatinase-associated-lipocalin-a-biomarker-of-renal-tubular-damage
#16
Atefeh Ordooei Javan, Jamshid Salamzadeh, Shervin Shokouhi, Zahra Sahraei
INTRODUCTION: Nephrotoxicity has been a concern with new dosing regimens of colistin. This study was designed to compare nephrotoxicity of high dose and conventional dose of colistin and the ability of detecting it using neutrophil gelatinase-associated lipocalin (NGAL). MATERIALS AND METHODS: A randomized clinical trial was carried out on 40 patients with multidrug-resistant gram-negative infections assigned into 2 groups to receive high and conventional doses of colistin...
November 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29190604/metabolic-response-to-mulberry-extract-supplementation-in-patients-with-diabetic-nephropathy-a-randomized-controlled-trial
#17
Mohsen Taghizadeh, Alireza Soleimani, Fereshteh Bahmani, Alireza Moravveji, Amir Asadi, Elahe Amirani, Narjes Farzin, Nasrin Sharifi, Afshin Naseri, Majid Dastorani, Zatollah Asemi
INTRODUCTION: This study aimed to evaluate the effects of mulberry extract administration on markers of insulin metabolism, lipid concentrations, and biomarkers of inflammation and oxidative stress in patients with diabetic nephropathy (DN). MATERIALS AND METHODS: Sixty patients were randomly allocated into 2 groups to receive either 300 mg/d of mulberry extract (n = 30) or placebo (n = 30), twice per day for 12 weeks. Fasting blood samples were taken at the onset of the study and 12 weeks after supplementation to examine markers of insulin metabolism, lipid concentrations, and biomarkers of inflammation and oxidative stress...
November 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29190603/upregulation-of-cabin1-during-injury-to-renal-tubular-epithelial-cells-in-rats
#18
Yueqiang Wen, Huiyuan Li, Peilan Zhou, Lingling Liu, Zebin Wang, Jianbo Liang
INTRODUCTION: Calcineurin-binding protein 1 (Cabin1) interacts with calcineurin and p53, but its function in renal tubular epithelial cell (RTEC) is unclear. We established 5/6 nephrectomized rats and angiotensin II-induced injury to the RTECs in vitro, to observe the expression of Cabin1 during RTEC injury. MATERIALS AND METHODS: Sprague-Dawley rats were sacrificed at 4 and 8 weeks after 5/6 nephrectomy. Renal pathology and mitochondrial damage were detected by light and electrical microscope...
November 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29190602/protective-effects-of-pomegranate-juice-on-nephrotoxicity-induced-by-captopril-and-gentamicin-in-rats
#19
Abbas Alimoradian, Saeed Changizi-Ashtiyani, Atefeh Ghiasabadi Farahani, Leila Kheder, Razie Rajabi, Akram Sharifi
INTRODUCTION: Nephrotoxicity is an important side effects of captopril and gentamicin. This study investigated the prophylactic and protective effects of pomegranate juice (PJ) on the kidney exposed to nephrotoxicity induced by these medications. MATERIALS AND METHODS: Wistar male rats received drinking water (groups 1 to 3) or PJ at doses of 4 mL/kg (group 4), 10 mL/kg (groups 5 and 7), and 15 mL/kg (group 6) for 14 days. Captopril and gentamicin were administrated on days 10 and 14 to groups 1 and 2, respectively, while groups 3 to 6 received both...
November 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29190601/cytokine-gene-polymorphism-in-children-with-idiopathic-nephrotic-syndrome
#20
Dina Abdel Razek Midan, Nesreen Gamal Elhelbawy, Mona Salah El-Din Habib, Iman Aly Ahmedy, Rasha Ibrahim Noreldin
INTRODUCTION: Idiopathic nephrotic syndrome (INS) is a glomerular disease with completely unclear pathogenesis and different responses to steroid therapy. This study aimed to investigate the role of cytokine genes promoter polymorphisms in steroid therapy responses. MATERIALS AND METHODS: One hundred children with INS and 30 healthy controls were studied. Genotyping of TNF-α-G308A single nucleotide polymorphism was done using polymerase chain reaction-restriction fragment length polymorphism method, while of IL-6-G174C single nucleotide polymorphism was done using real-time polymerase chain reaction...
November 2017: Iranian Journal of Kidney Diseases
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