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Gut and Liver

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https://www.readbyqxmd.com/read/29108399/effects-of-perianal-involvement-on-clinical-outcomes-in-crohn-s-disease-over-10-years
#1
Jin Young Yoon, Jae Hee Cheon, Soo Jung Park, Tae Il Kim, Won Ho Kim
Background/Aims: There was the assumption that CD patients with perianal lesions might have different clinical courses compared to those without. However, quantifiable data comparing the long-term outcomes between the two groups are scarce. Methods: We retrospectively reviewed 221 consecutive patients newly diagnosed with CD and registered at the IBD clinic of Severance Hospital, in Seoul, Korea, between January 1990 and October 2005. We compared patients with perianal CD (PCD) and non-perianal CD (NPCD) in terms of clinical outcomes over 10 years...
November 8, 2017: Gut and Liver
https://www.readbyqxmd.com/read/29069892/efficacy-of-a-three-dimensional-printed-training-simulator-for-endoscopic-biopsy-in-the-stomach
#2
Sunpyo Lee, Ji Yong Ahn, Minkyu Han, Gin Hyug Lee, Hee Kyong Na, Kee Wook Jung, Jeong Hoon Lee, Do Hoon Kim, Kee Don Choi, Ho June Song, Hwoon-Yong Jung
Background/Aims: We used three-dimensional (3D) printing technology to create a new biopsy simulator for the stomach and investigated its efficacy and realism in endoscopic biopsy training. Methods: A novel stomach biopsy simulator, with 10 biopsy sites, was produced using a 3D printer. We enrolled 26 participants, including 10 residents, six first-year fellows, five second-year fellows, and five faculty members. We recorded and reviewed five training sessions and evaluated the simulator with questionnaires using a 7-point Likert scale...
October 27, 2017: Gut and Liver
https://www.readbyqxmd.com/read/29069891/additive-effects-of-rebamipide-plus-proton-pump-inhibitors-on-the-expression-of-tight-junction-proteins-in-a-rat-model-of-gastro-esophageal-reflux-disease
#3
Tae-Geun Gweon, Jong-Hyung Park, Byung-Wook Kim, Yang Kyu Choi, Joon Sung Kim, Sung Min Park, Chang Whan Kim, Hyung-Gil Kim, Jun-Won Chung
Background/Aims: The aim of this study was to investigate the effects of rebamipide on tight junction proteins in the esophageal mucosa in a rat model of gastroesophageal reflux disease (GERD). Methods: GERD was created in rats by tying the proximal stomach. The rats were divided into a control group, a proton pump inhibitor (PPI) group, and a PPI plus rebamipide (PPI+R) group. Pantoprazole (5 mg/kg) was administered intraperitoneally to the PPI and PPI+R groups...
October 27, 2017: Gut and Liver
https://www.readbyqxmd.com/read/29069890/long-term-effects-of-helicobacter-pylori-eradication-on-metachronous-gastric-cancer-development
#4
Seung Jun Han, Sang Gyun Kim, Joo Hyun Lim, Ji Min Choi, Sooyeon Oh, Jae Yong Park, Jung Kim, Joo Sung Kim, Hyun Chae Jung
Background/Aims: Gastric mucosal atrophy and intestinal metaplasia due to Helicobacter pylori infection are the main precursor lesions of gastric cancer. The aim of this study was to evaluate the long-term effects of H. pylori eradication on the progression of precancerous lesions to metachronous cancer after endoscopic resection of early gastric cancer (EGC). Methods: Patients who underwent endoscopic resection of EGC were retrospectively reviewed. Changes in precancerous lesions and development of metachronous cancer were compared according to H...
October 27, 2017: Gut and Liver
https://www.readbyqxmd.com/read/29069889/characterizing-helicobacter-pylori-caga-in-myanmar
#5
Thein Myint, Muhammad Miftahussurur, Ratha-Korn Vilaichone, New Ni, Than Than Aye, Phawinee Subsomwong, Tomohisa Uchida, Varocha Mahachai, Yoshio Yamaoka
Background/Aims: Differences in the Helicobacter pylori infection rate are not sufficient to clarify the dissimilarity of gastric cancer incidence between Myanmar and its neighboring countries. To better understand this trend, the H. pylori virulence gene cagA was characterized in Myanmar. Methods: Glutamate-Proline-Isoleucine-Tyrosine-Alanine (EPIYA) patterns and CagA multimerization (CM) motifs of cagA genotypes were examined by performing polymerase chain reactions and DNA sequencing...
October 27, 2017: Gut and Liver
https://www.readbyqxmd.com/read/29069888/tumor-marker-kinetics-as-prognosticators-in-patients-with-unresectable-gallbladder-adenocarcinoma-undergoing-palliative-chemotherapy
#6
Jae Woo Lee, Yong-Tae Kim, Sang Hyub Lee, Jun Hyuk Son, Jin Woo Kang, Ji Kon Ryu, Dong Kee Jang, Woo Hyun Paik, Ban Seok Lee
Background/Aims: To determine the prognostic value of carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 in gallbladder cancer (GBC) during palliative chemotherapy. Methods: One hundred and twenty-three patients with pathologically confirmed unresectable GBC were included. Differences in serum CEA and CA 19-9 levels before and after chemotherapy were measured. Receiver operating characteristic curve analysis, Kaplan-Meier analyses of CEA, CA 19-9, and combined changes were performed to assess the optimal cutoff values and survival rates...
October 27, 2017: Gut and Liver
https://www.readbyqxmd.com/read/29069887/combination-of-transient-elastography-and-an-enhanced-liver-fibrosis-test-to-assess-the-degree-of-liver-fibrosis-in-patients-with-chronic-hepatitis-b
#7
Ja Yoon Heo, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Hyon-Suk Kim, Young Nyun Park, Kwang-Hyub Han, Kijun Song, Seung Up Kim
Background/Aims: Liver stiffness (LS) was assessed using transient elastography, and the enhanced liver fibrosis (ELF) test was performed to accurately assess fibrotic burden. We validated the LS-ELF algorithm and investigated whether the sequential LS-ELF algorithm performs better than concurrent combination of these analyses in chronic hepatitis B (CHB) patients. Methods: Between 2009 and 2013, 222 CHB patients who underwent liver biopsy (LB), as well as LS measurement and the ELF test, were enrolled...
October 27, 2017: Gut and Liver
https://www.readbyqxmd.com/read/29050194/update-on-the-pathophysiology-and-management-of-anorectal-disorders
#8
REVIEW
Tanisa Patcharatrakul, Satish S C Rao
Anorectal disorders are common and present with overlapping symptoms. They include several disorders with both structural and functional dysfunction(s). Because symptoms alone are poor predictors of the underlying pathophysiology, a diagnosis should only be made after evaluating symptoms and physiologic and structural abnormalities. A detailed history, a thorough physical and digital rectal examination and a systematic evaluation with high resolution and/or high definition three-dimensional (3D) anorectal manometry, 3D anal ultrasonography, magnetic resonance defecography and neurophysiology tests are essential to correctly identify these conditions...
October 23, 2017: Gut and Liver
https://www.readbyqxmd.com/read/29032661/a-prospective-study-of-eosinophilic-esophagitis-and-the-expression-of-tight-junction-proteins-in-patients-with-gastroesophageal-reflux-disease-symptoms
#9
Kenichiro Okimoto, Makoto Arai, Hideaki Ishigami, Keiko Saito, Shoko Minemura, Daisuke Maruoka, Tomoaki Matsumura, Tomoo Nakagawa, Tatsuro Katsuno, Masaki Suzuki, Yukio Nakatani, Osamu Yokosuka
Background/Aims: Eosinophilic esophagitis (EoE) is often erroneously diagnosed as gastroesophageal reflex disease (GERD). The aim of this study is to investigate the prevalence of EoE and the expression of tight junction (TJ) proteins in patients with GERD symptoms. Methods: One hundred patients with GERD symptoms and 10 healthy controls were prospectively studied. Sixty-two patients had symptoms refractory to proton pump inhibitors (PPI). All patients underwent esophageal biopsy...
October 17, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28950691/helicobacter-pylori-is-associated-with-mir-133a-expression-through-promoter-methylation-in-gastric-carcinogenesis
#10
Joo Hyun Lim, Sang Gyun Kim, Ji Min Choi, Hyo-Joon Yang, Joo Sung Kim, Hyun Chae Jung
Background/Aims: To investigate whether Helicobacter pylori eradication can reverse epigenetic silencing of microRNAs (miRNAs) which are associated with H. pylori-induced gastric carcinogenesis. Methods: We examined expression and promoter methylation of miR-34b/c, miR-133a, let-7a, and let-7i in gastric cancer cell line, before/after demethylation. Among them, epigenetically controlled miRNAs were identified. Their expression and promoter methylation was examined in human tissues of H...
September 28, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28918609/associations-among-gastric-juice-ph-atrophic-gastritis-intestinal-metaplasia-and-helicobacter-pylori-infection
#11
Jihee Sung, Nayoung Kim, Jongchan Lee, Young-Jae Hwang, Hyoung Woo Kim, Jung Wha Chung, Jin-Wook Kim, Dong Ho Lee
Background/Aims: Gastric juice plays a crucial role in the physiology of the stomach. The aim of this study is to evaluate associations among the pH of gastric juice, atrophic gastritis (AG), intestinal metaplasia (IM), pepsinogen, and Helicobacter pylori infection. Methods: Gastric biopsies and juice were collected from 46 subjects who underwent endoscopies at Seoul National University Bundang Hospital between November 2011 and March 2013. H. pylori, AG and IM were evaluated, and pepsinogen I or II, I/II ratio and interleukin (IL)-1β levels were measured...
September 19, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28873511/umbilical-cord-mesenchymal-stem-cell-treatment-for-crohn-s-disease-a-randomized-controlled-clinical-trial
#12
Jian Zhang, Samei Lv, Xiaojing Liu, Bin Song, Liping Shi
Background/Aims: Stem cell therapy has been applied to treat a variety of autoimmune diseases, including Crohn's disease (CD), but few studies have examined the use of umbilical cord mesenchymal stem cells (UC-MSCs). This trial sought to investigate the efficacy and safety of UC-MSCs for the treatment of CD. Methods: Eighty-two patients who had been diagnosed with CD and had received steroid maintenance therapy for more than 6 months were included in this study...
September 7, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28873510/knowledge-gaps-among-physicians-caring-for-multiethnic-populations-at-increased-gastric-cancer-risk
#13
Shailja C Shah, Steven H Itzkowitz, Lina Jandorf
Background/Aims: Although gastric cancer (GC) prevalence in the United States overall is low, there is significantly elevated risk in certain racial/ethnic groups. Providers caring for high-risk populations may not be fully aware of GC risk factors and may underestimate the potential for selective screening. Our aim was to identify knowledge gaps among healthcare providers with respect to GC. Methods: An Internet-based survey was distributed to primary care providers (PCPs) and gastroenterologists in New York City, which included questions regarding provider demographics, practice environment, GC risk factors, Helicobacter pylori, and screening practices...
September 7, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28873509/can-more-aggressive-treatment-improve-prognosis-in-patients-with-hepatocellular-carcinoma-a-direct-comparison-of-the-hong-kong-liver-cancer-and-barcelona-clinic-liver-cancer-algorithms
#14
Young-Sun Lee, Yeon Seok Seo, Ji Hoon Kim, Juneyoung Lee, Hae Rim Kim, Yang Jae Yoo, Tae Suk Kim, Seong Hee Kang, Sang Jun Suh, Moon Kyung Joo, Young Kul Jung, Beom Jae Lee, Hyung Joon Yim, Jong Eun Yeon, Jae Seon Kim, Jong-Jae Park, Soon Ho Um, Young-Tae Bak, Kwan Soo Byun
Background/Aims: In addition to the globally endorsed Barcelona Clinic Liver Cancer (BCLC) staging system, other algorithms or staging systems have been developed, including the Hong Kong Liver Cancer (HKLC) staging system. This study aimed to validate the HKLC staging system relative to the BCLC staging system for predicting survival for hepatocellular carcinoma (HCC) patients in Korea. Methods: From 2004 to 2013, 2,571 patients newly diagnosed with HCC were consecutively enrolled at three Korea University medical centers...
September 7, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28873508/fecal-immunochemical-test-and-fecal-calprotectin-results-show-different-profiles-in-disease-monitoring-for-ulcerative-colitis
#15
Sakiko Hiraoka, Toshihiro Inokuchi, Asuka Nakarai, Shiho Takashima, Daisuke Takei, Yuusaku Sugihara, Masahiro Takahara, Keita Harada, Hiroyuki Okada, Jun Kato
Background/Aims: Both fecal immunochemical test (FIT) and fecal calprotectin (Fcal) results are useful biomarkers for ulcerative colitis (UC). However, the situations in which each marker should be used are largely unknown. Methods: A total of 110 colonoscopy intervals of UC patients were assessed, and correlations between changes in colonoscopic findings and changes in the two aforementioned fecal markers were examined. Results: Among patients with mucosal healing (MH) and negative FIT or Fcal results at the initial colonoscopy, FIT and Fcal findings exhibited accuracies of 93% (38/41) and 79% (26/33), respectively, for predicting the results of the subsequent examination...
September 7, 2017: Gut and Liver
https://www.readbyqxmd.com/read/29081212/low-serum-pancreatic-amylase-and-lipase-values-are-simple-and-useful-predictors-to-diagnose-chronic-pancreatitis
#16
Hyoung-Chul Oh, Chang-Il Kwon, Ihab I. El Hajj, Jeffrey J Easler, James Watkins, Evan L Fogel, Lee McHenry, Stuart Sherman, Michelle K Zimmerman, Glen A Lehman
Background/Aims: This study aimed to evaluate the diagnostic role of low serum amylase and lipase values in the detection of chronic pancreatitis. Methods: Patients underwent endoscopic retrograde cholangiopancreatography and were diagnosed with non-calcific chronic pancreatitis (NCCP; n=99) and calcific chronic pancreatitis (CCP; n=112). Patient serum amylase and lipase values were compared with those of healthy controls (H; n=170). Results: The median serum amylase (normal range, 19 to 86 U/L) and lipase values (7 to 59 U/L) (P₂₅-P₇₅) were 47...
November 15, 2017: Gut and Liver
https://www.readbyqxmd.com/read/29081211/estimation-of-direct-medical-costs-related-to-chronic-hepatitis-c-a-rationale-for-early-antiviral-therapy
#17
EDITORIAL
Do Young Kim
No abstract text is available yet for this article.
November 15, 2017: Gut and Liver
https://www.readbyqxmd.com/read/29081210/can-we-trust-safety-of-tenofovir-disoproxil-in-patients-with-decompensated-cirrhosis
#18
EDITORIAL
Hyunwoo Oh, Dae Won Jun
No abstract text is available yet for this article.
November 15, 2017: Gut and Liver
https://www.readbyqxmd.com/read/29081209/the-role-of-il-10-in-gastric-spasmolytic-polypeptide-expressing-metaplasia-related-carcinogenesis
#19
EDITORIAL
Dae Jin Park, Sung Eun Kim
No abstract text is available yet for this article.
November 15, 2017: Gut and Liver
https://www.readbyqxmd.com/read/29081208/does-proton-pump-inhibitor-increase-the-clostridium-difficile-infection-risk-in-the-treatment-and-prophylaxis-of-stress-ulcers-than-histanime-2-receptor-antagonist
#20
EDITORIAL
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