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Gut and Liver

Boris Blechacz
Cholangiocarcinoma (CCA) is the second most common primary malignancy. Although it is more common in Asia, its incidence in Europe and North America has significantly increased in recent decades. The prognosis of CCA is dismal. Surgery is the only potentially curative treatment, but the majority of patients present with advanced stage disease, and recurrence after resection is common. Over the last two decades, our understanding of the molecular biology of this malignancy has increased tremendously, diagnostic techniques have evolved, and novel therapeutic approaches have been established...
December 8, 2016: Gut and Liver
Su Youn Nam
Obesity is a growing medical and public health problem worldwide. Many digestive diseases are related to obesity. In this article, the current state of our knowledge of obesity-related digestive diseases, their pathogenesis, and the medical and metabolic consequences of weight reduction are discussed. Obesity-related digestive diseases include gastroesophageal reflux disease, Barrett's esophagus, esophageal cancer, colon polyp and cancer, nonalcoholic fatty liver disease, hepatitis C-related disease, hepatocellular carcinoma, gallstone, cholangiocarcinoma, and pancreatic cancer...
November 29, 2016: Gut and Liver
Ye-Young Rhee, Kyung-Ju Kim, Gyeong Hoon Kang
The concept of a CpG island methylator phenotype (CIMP) was first introduced by Toyota and Issa to describe a subset of colorectal cancers (CRCs) with concurrent hypermethylation of multiple CpG island loci. The concept of CIMP as a molecular carcinogenesis mechanism was consolidated by the identification of the serrated neoplasia pathway, in which CIMP participates in the initiation and progression of serrated adenomas. Distinct clinicopathological and molecular features of CIMP-high (CIMP-H) CRCs have been characterized, including proximal colon location, older age of onset, female preponderance, and frequent associations of high-level microsatellite instability and BRAF mutations...
November 28, 2016: Gut and Liver
Samantha Noseworthy
No abstract text is available yet for this article.
November 24, 2016: Gut and Liver
Kang-Min Zhuang, Yu-Bin Guo, Si-De Liu
No abstract text is available yet for this article.
November 24, 2016: Gut and Liver
Ya-Min Lai, Wei-Yan Yao, Yao He, Xuan Jiang, Yu-Bei Gu, Min-Hu Chen, Yu-Lan Liu, Yao-Zong Yuan, Jia-Ming Qian
Background/Aims: Patients with active ulcerative colitis (UC) have elevated levels of activated myeloid-derived leukocytes as a source of inflammatory cytokines. The selective depletion of these leukocytes by adsorptive granulocyte/monocyte apheresis (GMA) with an Adacolumn should alleviate inflammation, promote remission and enhance drug efficacy. However, studies have reported contrasting efficacy outcomes based on patients' baseline demographic variables. This study was undertaken to understand the demographic features of GMA responders and nonresponders...
November 16, 2016: Gut and Liver
Hyun Joo Song, Jeong Seop Moon, Seong Ran Jeon, Jin-Oh Kim, Jinsu Kim, Dae Young Cheung, Myung-Gyu Choi, Yun Jeong Lim, Ki-Nam Shim, Byong Duk Ye, Jae Hee Cheon, Cheol Hee Park, Hyun-Soo Kim, Ji Hyun Kim, Dong Kyung Chang, Jae Hyuk Do, Kyeong Ok Kim, Byung Ik Jang, Sung-Jae Shin
Background/Aims: In some cases, chronic diarrhea is unexplained, and small bowel disorders may be one of the causes. The aim of this study was to assess the diagnostic yield and clinical impact of video capsule endoscopy (VCE) in patients with chronic diarrhea. Methods: We retrospectively analyzed records from October 2002 to August 2013 in the VCE nationwide database registry (n=2,964). Ninety-one patients from 15 medical centers (60 males and 31 females; mean age, 47±19 years) were evaluated for VCE as a result of chronic diarrhea...
November 14, 2016: Gut and Liver
Kichul Yoon, Nayoung Kim, Jaeyeon Kim, Jung Won Lee, Hye Seung Lee, Jong-Chan Lee, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Sang-Hoon Ahn, Do Joong Park, Hyung Ho Kim, Yoon Jin Lee, Kyoung-Ho Lee, Young-Hoon Kim, Dong Ho Lee
Background/Aims: Helicobacter pylori eradication is recommended in patients with early gastric cancer. However, the possibility of spontaneous regression raises a question for clinicians about the need for "retesting" postoperative H. pylori status. Methods: Patients who underwent curative gastrectomy at Seoul National University Bundang Hospital and had a positive H. pylori status without eradication therapy at the time of gastric cancer diagnosis were prospectively enrolled in this study...
November 14, 2016: Gut and Liver
Seung Kim, Hong Koh, Joon Soo Lee
Background/Aims: Neurologically impaired patients frequently suffer from gastrointestinal tract problems, such as gastroesophageal reflux disease (GERD). In this study, we aimed to define the risk factors for GERD in neurologically impaired children. Methods: From May 2006 to March 2014, 101 neurologically impaired children who received 24-hour esophageal pH monitoring at Severance Children's Hospital were enrolled in the study. The esophageal pH finding and the clinical characteristics of the patients were analyzed...
November 14, 2016: Gut and Liver
Daniel S Strand, Daejin Kim, David A Peura
Proton pump inhibitors (PPIs) were clinically introduced more than 25 years ago and have since proven to be invaluable, safe, and effective agents for the management of a variety of acid-related disorders. Although all members in this class act in a similar fashion, inhibiting active parietal cell acid secretion, there are slight differences among PPIs relating to their pharmacokinetic properties, metabolism, and Food and Drug Administration (FDA)-approved clinical indications. Nevertheless, each is effective in managing gastroesophageal reflux disease and uncomplicated or complicated peptic ulcer disease...
November 14, 2016: Gut and Liver
Nobuyuki Toshikuni
Chronic hepatitis C virus (HCV) infection may eventually lead to liver cirrhosis (LC), a condition associated with a high risk of liver failure and hepatocellular carcinoma. Although interferon (IFN)-based therapy has made substantial contributions to the management of HCV-infected patients, this therapy has limitations for LC patients in terms of eligibility, tolerability, relatively low and high rates of sustained virological response (SVR), and serious adverse events. Therapy with newly developed direct-acting antiviral agents (DAAs) can overcome these limitations in IFN-based therapy...
November 14, 2016: Gut and Liver
Hirohito Mori, Hideki Kobara, Tsutomu Masaki
No abstract text is available yet for this article.
October 13, 2016: Gut and Liver
Sung Wook Hwang, Hyungil Seo, Gwang-Un Kim, Eun Mi Song, Myeongsook Seo, Sang Hyoung Park, Eunja Kwon, Ho-Su Lee, Dong-Hoon Yang, Kyung-Jo Kim, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Jin-Ho Kim, Suk-Kyun Yang
Background/Aims: The reported rates of current smoking at the time of Crohn's disease (CD) diagnosis tend to be low in East Asian studies. However, we hypothesized that East Asian patients may be reluctant to disclose their smoking history, likely because of the influence of the Confucian culture. Methods: We prospectively re-evaluated the smoking status at diagnosis in 1,437 Korean CD patients whose smoking status had been reported in our previous study. Results: After re-evaluation, the current smokers at diagnosis increased from 388 patients (27...
October 13, 2016: Gut and Liver
Hiroyasu Iwasaki, Takashi Mizushima, Yuta Suzuki, Shigeki Fukusada, Kenta Kachi, Takanori Ozeki, Kaiki Anbe, Hironobu Tsukamoto, Fumihiro Okumura, Takashi Joh, Hitoshi Sano
Background/Aims: Self-expandable metallic stent (SEMS) placement is effective for dysphagia that results from malignant obstruction of the esophagus or gastric cardia; however, stent-related complications may be life-threatening. Thus, the goal of this study was to identify risk factors associated with complications following esophageal stenting. Methods: Of the 71 patients who underwent SEMS placement for dysphagia as a result of malignant stricture of the esophagus or gastric cardia, 53 patients with squamous cell carcinoma or adenocarcinoma, without previous SEMS placement, without a fistula, and without recurrent tumor after surgery were retrospectively identified...
October 13, 2016: Gut and Liver
Su Rin Shin, Young Seok Kim, Young-Seok Lim, June Sung Lee, Jin Woo Lee, Sun Myung Kim, Sook-Hyang Jeong, Joo Hyun Sohn, Myung Seok Lee, Sang Hoon Park
Background/Aims: Because of the limited geographic distribution, there have been insufficient data regarding hepatitis C virus (HCV) genotype 6 in Korea. This study aimed to investigate the clinical characteristics and available treatment outcomes of patients with genotype 6 HCV in Korea. Methods: From 2004 to 2014, data were collected from Korean patients infected with genotype 6 HCV in eight hospitals. Results: Thirty-two patients had genotype 6 HCV...
October 13, 2016: Gut and Liver
Eaum Seok Lee, Seok Hyun Kim, Hyun Jin Kim, Kyung Hee Kim, Byung Seok Lee, Bon Jeong Ku
Background/Aims: Growth differentiation factor 15 (GDF-15) belongs to the transforming growth factor-β superfamily. GDF-15 is emerging as a biomarker for several diseases. The aim of this study was to determine the clinical performances of GDF-15 for the prediction of liver fibrosis and severity in chronic liver disease. Methods: The serum GDF-15 levels were examined via enzyme immunoassay in 145 patients with chronic liver disease and 101 healthy individuals. The patients with chronic liver disease consisted of 54 patients with chronic hepatitis, 44 patients with compensated liver cirrhosis, and 47 patients with decompensated liver cirrhosis...
October 13, 2016: Gut and Liver
Miyoung Choi, Sungwon Lim, Myung-Gyu Choi, Ki-Nam Shim, Seon Heui Lee
Background/Aims: As a result of the rapid development of medical diagnostic tools, physicians require concrete evidence to evaluate the effectiveness of the tools. We aimed to investigate the effectiveness and additional diagnostic benefits of capsule endoscopy (CE) in patients with small bowel Crohn's disease (CD). Methods: We performed a systematic search of databases, including MEDLINE, EMBASE, and the Cochrane Library, as well as eight domestic databases. Two reviewers independently screened all references...
October 13, 2016: Gut and Liver
Han Joon Kim, Jaemin Jeong, Sunhoo Park, Young-Woo Jin, Seung-Sook Lee, Seung Bum Lee, Dongho Choi
Background/Aims: Cancer is known to be a disease by many factors. However, specific results of reprogramming by pluripotency-related transcription factors remain to be scarcely reported. Here, we verified potential effects of pluripotent-related genes in hepatocellular carcinoma cancer cells. Methods: To better understand reprogramming of cancer cells in different genetic backgrounds, we used four liver cancer cell lines representing different states of p53 (HepG2, Hep3B, Huh7 and PLC)...
October 13, 2016: Gut and Liver
Hanjing Gao, Qing Song, Faqin Lv, Shan Wang, Yiru Wang, Xiaoyan Li, Yukun Luo, Xingguo Mei, Jie Tang
Background/Aims: This study investigated the protection provided by gabexate mesylate thermo-sensitive in-situ gel (GMTI) against grade III pancreatic trauma in rats. Methods: A grade III pancreatic trauma model with main pancreatic duct dividing was established, and the pancreas anatomical diagram, ascites, and serum biochemical indices, including amylase, lipase, C-reactive protein (CRP), interleukin 6 (IL- 6), and tumor necrosis factor-α (TNF-α), were examined...
September 20, 2016: Gut and Liver
Soo-Kyung Park, Chang Seok Song, Hyo-Joon Yang, Yoon Suk Jung, Kyu Yong Choi, Dong Hoe Koo, Kyung Eun Kim, Kyung Uk Jeong, Hyung Ook Kim, Hungdai Kim, Ho-Kyung Chun, Dong Il Park
In the version of this article initially published, the first affiliation (affiliation number 1) was incorrectly stated as "Division of Gastroentorology, Department of Internal Medicine." The correct affiliation is "Department of Internal Medicine."
November 15, 2016: Gut and Liver
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