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Gut and Liver

Viola Schlossberger, Mathias Worni, Christina Kihm, Matteo Montani, Christian Datz, Jochen Hampe, Felix Stickel
Background/Aims: Noninvasive markers of liver fibrosis in alcoholic liver disease (ALD) are crucial to establish early intervention. Previous studies have suggested that plasma levels of cleaved keratin-18 (K18; M30) fragments can predict the severity of liver disease. The aim of this study was to correlate plasma M30 levels with stages of liver fibrosis in ALD. Methods: Patients with ALD (n=139, 79.1% males) and liver histology were included, and plasma samples were collected to quantify plasma M30 levels...
July 5, 2018: Gut and Liver
Byung-Woo Kim, Chang-Mo Oh, Hwa Young Choi, Joong-Won Park, Hyunsoon Cho, Moran Ki
Background/Aims: There have been no nationwide studies to investigate the trends in incidence and 5-year survival rates of intra- and extrahepatic bile duct cancers and gallbladder cancer. Therefore, our study aimed to describe the incidence and 5-year survival rates of biliary tract cancers by subsites in South Korea. Methods: A total of 86,134 patients with biliary tract cancers were selected from the National Health Information Database. Age-standardized incidence rates and annual percentage changes were calculated...
June 22, 2018: Gut and Liver
Hannah Jo, Young Woo Eom, Hyun-Soo Kim, Hong Jun Park, Hee Man Kim, Mee-Yon Cho
Background/Aims: Regulatory dendritic cells (rDCs), which can be induced by mesenchymal stem cells (MSCs), play an important role in inducing and maintaining homeostasis of regulatory T cells and exhibit anti-inflammatory functions. In this study, we investigated whether MSCs could differentiate DCs into rDCs and compared the therapeutic effects of rDCs and MSCs on dextran sodium sulfate (DSS)-induced chronic colitis mice. Methods: Immature DCs (imDCs) and lipopolysaccharide (LPS)-treated mature DCs (mDCs) were co-cultured with MSCs for 48 hours, and then the profiles of surface markers and cytokines and regulatory roles of these DCs for primary splenocytes were analyzed...
June 22, 2018: Gut and Liver
Min Seong Kim, Sang Gyun Kim, Hyunsoo Chung, Jung Kim, Hyoungju Hong, Hee Jong Lee, Hyun Ju Kim, Min A Kim, Woo Ho Kim, Hyun Chae Jung
Background/Aims: Although forcep biopsy is performed for suspicious gastric tumors during endoscopy, it is difficult to determine treatment strategies for atypical gastric glands due to uncertainty of the diagnosis. The aim of this study was to investigate clinical implications and risk factors for predicting malignancy in atypical gastric glands during forcep biopsy. Methods: We retrospectively reviewed medical records of 252 patients with a diagnosis of atypical gastric gland during forcep biopsy...
June 22, 2018: Gut and Liver
Gayam Vijay, Hossain Muhammad Rajib, Khalid Mazin, Chakaraborty Sandipan, Mukhtar Osama, Dahal Sumit, Mandal Amrendra Kumar, Gill Arshpal, Garlapati Pavani, Sreedevi Ramakrishnaiah, Mowyad Khalid, Sherigar Jagannath, Mansour Mohammed, Mohanty Smruti
Background/Aims: Limited data exist comparing the safety and efficacy of direct-acting antivirals (DAAs) in hepatitis C virus (HCV) monoinfected and HCV/human immunodeficiency virus (HIV) coinfected patients in the real-world clinic practice setting. Methods: All HCV monoinfected and HCV/HIV coinfected patients treated with DAAs between January 2014 and October 2017 in community clinic settings were retrospectively analyzed. Pretreatment baseline patient characteristics, treatment efficacy, factors affecting sustained virologic response at 12 weeks (SVR 12) after treatment, and adverse reactions were compared between the groups...
June 22, 2018: Gut and Liver
Jiwoon Choi, Taek Chung, Hyungjin Rhee, Young-Joo Kim, Youngsic Jeon, Jeong Eun Yoo, Songmi Noh, Dai Hoon Han, Young Nyun Park
Background/Aims: Lysyl oxidase-like 2 (LOXL2), a collagen-modifying enzyme, has been implicated in cancer invasiveness and metastasis. Methods: We evaluated the expression of LOXL2 protein, in addition to carbonic anhydrase IX (CAIX), keratin 19, epithelial cell adhesion molecule, and interleukin 6, in 105 resected hepatocellular carcinomas (HCCs) by immunohistochemistry. Results: LOXL2 positivity was found in 14.3% (15/105) of HCCs, and it was significantly associated with high serum α-fetoprotein levels, poor differentiation, fibrous stroma, portal vein invasion, and advanced TNM stage (p<0...
June 22, 2018: Gut and Liver
Jung Won Park, Yehyun Park, Soo Jung Park, Tae Il Kim, Won Ho Kim, Jae Hee Cheon
Background/Aims: The cumulative surgery rate and postoperative relapse of intestinal Behçet's disease (BD) have been reported to be high. This study aimed to establish a scoring system based on follow-up endoscopic findings that can predict intestinal BD recurrence after surgery. Methods: Fifty-four patients with intestinal BD who underwent surgery due to bowel complications and underwent follow-up colonoscopy were retrospectively investigated. Their clinical data, including colonoscopic findings, were retrieved...
June 22, 2018: Gut and Liver
Geunwu Gimm, Young Chang, Hyo-Cheol Kim, Aesun Shin, Eun Ju Cho, Jeong-Hoon Lee, Su Jong Yu, Jung-Hwan Yoon, Yoon Jun Kim
Background/Aims: Gastric varices (GVs) are a major cause of upper gastrointestinal bleeding in patients with liver cirrhosis. The current treatments of choice are balloon-occluded retrograde transvenous obliteration (BRTO) and the placement of a transjugular intrahepatic portosystemic shunt (TIPS). We aimed to compare the efficacy and outcomes of these two methods for the management of GV bleeding. Methods: This retrospective study included consecutive patients who received BRTO (n=157) or TIPS (n=19) to control GV bleeding from January 2005 to December 2014 at a single tertiary hospital in Korea...
June 22, 2018: Gut and Liver
Yoon Jinn Choi, Dong Ho Lee, Kyung-Do Han, Hyun Soo Kim, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Nayoung Kim
Background/Aim: The association between metabolic syndrome and colorectal cancer (CRC) has been suggested as one of causes for the increasing incidence of CRC, particularly in younger age groups. The present study examined whether the current age threshold (50 years) for CRC screening in Korea requires modification when considering increased metabolic syndrome. Methods: We analyzed data from the National Health Insurance Corporation database, which covers ~97% of the population in Korea...
June 22, 2018: Gut and Liver
Kyeong Ok Kim, Kyu Chan Huh, Sung Pil Hong, Won Hee Kim, Hyuk Yoon, Sang Wook Kim, Yeon Soo Kim, Jong Ha Park, Jun Lee, Bum Jae Lee, Young Sook Park
Background/Aims: The aims of the present study were to determine the frequency of interval colorectal cancers (CRCs) after surveillance colonoscopy and to compare the clinicopathologic features and survival outcomes of interval CRCs with those of non-interval CRCs. Methods: From January 2003 to December 2013, 66,016 follow-up colonoscopies for 38,412 patients performed within recommended time were reviewed retrospectively based on data from 11 tertiary hospitals in South Korea...
June 22, 2018: Gut and Liver
Min Jae Yang, Jin Hong Kim, Jae Chul Hwang, Byung Moo Yoo, Sang Hyub Lee, Ji Kon Ryu, Yong-Tae Kim, Sang Myung Woo, Woo Jin Lee, Seok Jeong, Don Haeng Lee
Background/Aims: Although endoscopic bilateral stent-in-stent placement is challenging, many recent studies have reported promising outcomes regarding technical success and endoscopic reintervention. This study aimed to evaluate the technical feasibility of stent-in-stent placement using large cell-type stents in patients with inoperable malignant hilar biliary obstruction. Methods: Forty-three patients with inoperable malignant hilar biliary obstruction from four academic centers were prospectively enrolled from March 2013 to June 2015...
June 22, 2018: Gut and Liver
Hyuk Yoon, Dong Ho Lee, Yong-Hyun Lee, Ju-Cheol Jeong, Soo Teik Lee, Myung-Gyu Choi, Seong Woo Jeon, Ki-Nam Shim, Gwang Ho Baik, Jae Gyu Kim, Jeong Seop Moon, In-Kyung Sung, Sang Kil Lee, Poong-Lyul Rhee, Hwoon-Yong Jung, Bong Eun Lee, Hyun Soo Kim, Sang Gyun Kim, Kee Myung Lee, Jae Kyu Seong, Jin Seok Jang, Jong-Jae Park
Background/Aims: To evaluate the efficacy and safety of a controlled release, once-daily formulation of mosapride (UI05MSP015CT) in patients with functional dyspepsia (FD). Methods: Patients with FD were randomly assigned (1:1) to receive either UI05MSP015CT (15 mg once a day, study group) or mosapride (5 mg three times a day, control group) and corresponding placebo for 4 weeks. The primary endpoint was a change in the gastrointestinal symptom score (GIS) evaluated at enrollment and after 4 weeks...
June 22, 2018: Gut and Liver
Tae Hoon Lee, Sang-Heum Park, Jae Kook Yang, Su Jung Han, Suyeon Park, Hyun Jong Choi, Yun Nah Lee, Sang-Woo Cha, Jong Ho Moon, Young Deok Cho
Background/Aims: Needle-knife precut fistulotomy (NK-F) is a well-known freehand technique for difficult biliary cannulation (DBC). Another approach involves the use of Iso-Tome® , a modified precutting device with an insulated needle tip to prevent direct thermal injury. This comparative study aimed to evaluate the efficacy of the Iso-Tome® precut (IT-P) compared to that of NK-F for DBC. Methods: Patients with a naïve papilla who underwent early IT-P or NK-F for DBC were enrolled...
June 22, 2018: Gut and Liver
Tae-Hyeon Kim, Young-Sik Woo, Hyung-Ku Chon, Jin-Hyeok Hwang, Kyo-Sang Yoo, Woo-Jin Lee, Kwang-Hyuck Lee, Jong-Kyun Lee, Seok-Ho Dong, Chang-Hwan Park, Eun-Taek Park, Jong-Ho Moon, Ho-Gak Kim, Kwang-Bum Cho, Hong-Ja Kim, Seung-Ok Lee, Young-Koog Cheon, Jeong-Mi Lee, Jin-Woo Park, Myung-Hwan Kim
Background/Aims: Presence of enhanced mural nodules, which can be visualized using computed tomography (CT), is one of high-risk stigmata in branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs). Conversely, the absence of enhanced mural nodules on preoperative imaging does not exclude malignant risk. The present study aimed to investigate other morphological features as predictors of malignancy in "pure" BD-IPMNs without enhanced mural nodules on CT. Methods: This retrospective study included 180 patients with surgically confirmed "pure" BD-IPMNs of the pancreas and no enhanced mural nodules on preoperative CT...
June 22, 2018: Gut and Liver
Minjong Lee, Young Chang, Sohee Oh, Young Youn Cho, Dhong-Eun Jung, Hong Hyun Kim, Joon Yeul Nam, Hyeki Cho, Eun Ju Cho, Jeong-Hoon Lee, Su Jong Yu, Nam-Joon Yi, Kwang-Woong Lee, Dong Ho Lee, Jeong Min Lee, Jung-Hwan Yoon, Kyung-Suk Suh, Yoon Jun Kim
Background/Aims: Guidelines recommend surveillance for hepatocellular carcinoma (HCC) recurrence at 3-month intervals during the first year after curative treatment and 6-month intervals thereafter in all patients. This strategy does not reflect individual risk of recurrence. We aimed to stratify risk of recurrence to optimize surveillance intervals 1 year after treatment. Methods: We retrospectively analyzed 1,316 HCC patients treated with resection/radiofrequency ablation at Barcelona Clinic Liver Cancer stage 0/A...
June 22, 2018: Gut and Liver
Hye Won Lee, Soo Jung Park, Seong Ran Jeon, Byong Duk Ye, Jae Jun Park, Jae Hee Cheon, Tae Il Kim, Won Ho Kim
Background/Aims: Benign intestinal strictures are common complications in patients with inflammatory bowel disease (IBD). This study aimed to assess the long-term prognosis of endoscopic balloon dilation (EBD) to treat benign strictures in IBD patients. Methods: Patients with IBD who had benign strictures and who underwent EBD in four tertiary referral university hospitals between January 2004 and February 2014 were retrospectively reviewed. Technical success was defined as the ability to pass the scope through the stricture after balloon dilation, and clinical success was defined as improved obstructive symptoms...
June 22, 2018: Gut and Liver
Young Sook Park, Dong Shin Kim, Sang Woo Cho, Jong Won Park, Sang Jin Jeon, Tae Ju Moon, Seong Hwan Kim, Byoung Kwan Son, Tae Jeong Oh, Sungwhan An, Jeong Hwan Kim, Jeong Don Chae
Background/Aims: Syndecan-2 ( SDC2 ) methylation was previously reported as a sensitive serologic biomarker for the early detection of colorectal cancer (CRC). The purpose of this study was to investigate whether SDC2 methylation is detectable in precancerous lesions and to determine the feasibility of using SDC2 methylation for the detection of CRC and precancerous lesions in bowel lavage fluid (BLF). Methods: A total of 190 BLF samples were collected from the rectum at the beginning of colonoscopy from patients with colorectal neoplasm and healthy normal individuals...
June 22, 2018: Gut and Liver
Su Youn Nam, Young-Woo Kim, Bum Joon Park, Kum Hei Ryu, Hyun Boem Kim
Background/Aims: Although abdominal visceral fat has been associated with erosive esophagitis in cross-sectional studies, there are few data on the longitudinal effect. We evaluated the effects of abdominal visceral fat change on the regression of erosive esophagitis in a prospective cohort study. Methods: A total of 163 participants with erosive esophagitis at baseline were followed up at 34 months and underwent esophagogastroduodenoscopy and computed tomography at both baseline and follow-up...
June 22, 2018: Gut and Liver
Jihye Park, Jae Hee Cheon
Intestinal Behçet's disease is a rare, immune-mediated chronic intestinal inflammatory disease; therefore, clinical trials to optimize the management and treatment of patients are scarce. Moreover, intestinal Behçet's disease is difficult to treat and often requires surgery because of the failure of conventional medical treatment. Administration of anti-tumor necrosis factor α, a potential therapeutic strategy, is currently under active clinical investigation, and evidence of its effectiveness for both intestinal Behçet's disease and inflammatory bowel diseases has been accumulating...
May 24, 2018: Gut and Liver
Atsushi Okuda, Takeshi Ogura, Miyuki Imanishi, Akira Miyano, Nobu Nishioka, Kazuhide Higuchi
Background/Aims: Recently, recombinant human soluble thrombomodulin (rTM) has been developed as a new drug for disseminated intravascular coagulation (DIC). This study aims to evaluate the clinical benefit of rTM in patients with sepsis-induced DIC caused by acute cholangitis who underwent biliary drainage. Methods: Patients were divided into two groups: the rTM therapy group and the non-rTM therapy group. The primary outcome was the DIC resolution rate at 7 days, and the secondary outcome was 28-day mortality rate...
April 27, 2018: Gut and Liver
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