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Gut and Liver

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https://www.readbyqxmd.com/read/29730907/is-the-isolated-tip-needle-knife-precut-as-effective-as-conventional-precut-fistulotomy-in-difficult-biliary-cannulation
#1
Tae Hoon Lee, Sang Heum Park, Jae Kook Yang, Su Jung Han, Suyeon Park, Hyun Jong Choi, Yun Nah Lee, Sang-Woo Cha, Jong Ho Moon, Young Deok Cho
Background/Aims: Needle-knife precut fistulotomy (NK-F) is a well-known freehand technique for difficult biliary cannulation (DBC). Another approach involves the Iso-Tome® , a modified precutting device with an insulated needle tip to prevent direct thermal injury. This comparative study aimed to evaluate the efficacy of the Iso-Tome® precut (IT-P) compared to that of NK-F for DBC. Methods: Patients with a naïve papilla who underwent early IT-P or NK-F for DBC were enrolled...
May 4, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29730906/predictors-of-malignancy-in-pure-branch-duct-intraductal-papillary-mucinous-neoplasm-of-the-pancreas-without-enhanced-mural-nodules-on-ct-imaging-a-nationwide-multicenter-study
#2
Tae Hyeon Kim, Young Sik Woo, Hyung Ku Chon, Jin Hyeok Hwang, Kyo Sang Yoo, Woo Jin Lee, Kwang Hyuck Lee, Jong Kyun Lee, Seok Ho Dong, Chang Hwan Park, Eun Taek Park, Jong Ho Moon, Ho Gak Kim, Kwang Bum Cho, Hong Ja Kim, Seung Ok Lee, Young Koog Cheon, Jeong-Mi Lee, Jin Woo Park, Myung-Hwan Kim
Background/Aim: Enhanced mural nodules, which can be visualized using computed tomography (CT), constitute high-risk stigmata in branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs). Conversely, the absence of enhanced mural nodules on preoperative imaging does not exclude malignant risk. The present study aimed to investigate other morphological features as predictors of malignancy in "pure" BD-IPMNs without enhanced mural nodules on CT. Method: This retrospective study included 180 patients with surgically confirmed "pure" BD-IPMNs of the pancreas and no enhanced mural nodules on preoperative CT...
May 4, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29730905/assessment-of-the-surveillance-interval-at-1-year-after-curative-treatment-in-hepatocellular-carcinoma-risk-stratification
#3
Minjong Lee, Young Chang, Sohee Oh, Young Youn Cho, Dhong-Eun Jung, Hong Hyun Kim, Joon Yeul Nam, Hyeki Cho, Eun Ju Cho, Jeong-Hoon Lee, Su Jong Yu, Nam-Joon Yi, Kwang-Woong Lee, Dong Ho Lee, Jeong Min Lee, Jung-Hwan Yoon, Kyung-Suk Suh, Yoonjun Kim
Background/Aims: Guidelines recommend surveillance for hepatocellular carcinoma (HCC) recurrence at 3-month intervals during the first year after curative treatment and 6-month intervals thereafter in all patients. This strategy does not reflect individual risk of recurrence. We aimed to stratify risk of recurrence to optimize surveillance intervals during the first year after treatment. Methods: We retrospectively analyzed 1,316 HCC patients treated with resection/radiofrequency ablation at Barcelona Clinic Liver Cancer stage 0/A...
May 4, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29730904/long-term-outcomes-of-endoscopic-balloon-dilation-for-benign-strictures-in-patients-with-inflammatory-bowel-disease
#4
Hye Won Lee, Soo Jung Park, Seong Ran Jeon, Byong Duk Ye, Jae Jun Park, Jae Hee Cheon, Tae Il Kim, Won Ho Kim
Background/Aims: Benign intestinal strictures are common complications in patients with inflammatory bowel disease (IBD). This study aimed to assess the long-term prognosis of endoscopic balloon dilation (EBD) to treat benign strictures in IBD patients. Methods: Patients with IBD who had benign strictures and who underwent EBD in four tertiary referral university hospitals between January 2004 and February 2014 were retrospectively reviewed. Technical success was defined as the ability to pass the scope through the stricture after balloon dilation, and clinical success was defined as improved obstructive symptoms...
May 4, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29730903/analysis-of-syndecan-2-methylation-in-bowel-lavage-fluid-for-detection-of-colorectal-neoplasm
#5
Young Sook Park, Dong Shin Kim, Sang Woo Cho, Jong Won Park, Sang Jin Jeon, Tae Ju Moon, Seong Hwan Kim, Byoung Kwan Son, TaeJeong Oh, Sungwhan An, Jeong HwanKim, Jeong Don Chae
Background/Aims: Syndecan-2 ( SDC2 ) methylation was previously reported as a sensitive serologic biomarker for the early detection of colorectal cancer (CRC). The purpose of this study was to investigate whether SDC2 methylation is detectable in precancerous lesions and to determine the feasibility of using SDC2 methylation for the detection of CRC and precancerous lesions in bowel lavage fluid (BLF). Methods: A total of 190 BLF samples were collected from the rectum at the beginning of colonoscopy from patients with colorectal neoplasm and healthy normal individuals...
May 4, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29730902/effect-of-abdominal-visceral-fat-change-on-regression-of-erosive-esophagitis-prospective-cohort-study
#6
Su Youn Nam, Young Woo Kim, Bum Joon Park, Kum Hei Ryu, Hyun Boem Kim
Background/Aims: Although abdominal visceral fat has been associated with erosive esophagitis in cross-sectional studies, there are few data on the longitudinal effect. We evaluated the effects of abdominal visceral fat change on the regression of erosive esophagitis in a prospective cohort study. Methods: A total of 163 participants with erosive esophagitis at baseline were followed up at 34 months and underwent esophagogastroduodenoscopy and computed tomography at both baseline and follow-up...
May 4, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29699063/clinical-impact-of-recombinant-soluble-thrombomodulin-for-disseminated-intravascular-coagulation-associated-with-severe-acute-cholangitis
#7
Atsushi Okuda, Takeshi Ogura, Miyuki Imanishi, Akira Miyano, Nobu Nishioka, Kazuhide Higuchi
Background/Aims: Recently, recombinant human soluble thrombomodulin (rTM) has been developed as a new drug for disseminated intravascular coagulation (DIC). This study aims to evaluate the clinical benefit of rTM in patients with sepsis-induced DIC caused by acute cholangitis who underwent biliary drainage. Methods: Patients were divided into two groups: the rTM therapy group and the non-rTM therapy group. The primary outcome was the DIC resolution rate at 7 days, and the secondary outcome was 28-day mortality rate...
April 27, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29699062/patient-response-to-endoscopic-therapy-for-gastroesophageal-varices-based-on-endoscopic-ultrasound-findings
#8
Yujen Tseng, Lili Ma, Tiancheng Luo, Xiaoqing Zeng, Feng Li, Na Li, Yichao Wei, Shiyao Chen
Background/Aims: Gastroesophageal variceal hemorrhage is a common complication of portal hypertension. Endoscopic therapy is currently recommended for preventing gastroesophageal variceal rebleed. However, the rate of variceal rebleed and its associated mortality remain concerning. This study is aimed at differentiating patient response to endoscopic therapy based on endoscopic ultrasound (EUS) findings. Methods: One-hundred seventy patients previously treated with repeat endoscopic therapy for secondary prophylaxis were enrolled and classified into two groups based on treatment response...
April 27, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29699061/expression-of-fibroblast-growth-factor-21-and-%C3%AE-klotho-regulates-hepatic-fibrosis-through-the-nuclear-factor-%C3%AE%C2%BAb-and-c-jun-n-terminal-kinase-pathways
#9
Kyong Joo Lee, Yoon Ok Jang, Seung-Kuy Cha, Moon Young Kim, Kyu-Sang Park, Young Woo Eom, Soon Koo Baik
Background/Aims: Fibroblast growth factor (FGF) 21 is associated with hepatic inflammation and fibrosis. However, little is known regarding the effects of inflammation and fibrosis on the β-Klotho and FGF21 pathway in the liver. Methods: Enrolled patients had biopsy-confirmed viral or alcoholic hepatitis. FGF19, FGF21 and β-Klotho levels were evaluated using enzyme-linked immunosorbent assay, real-time polymerase chain reaction, and Western blotting. Furthermore, we explored the underlying mechanisms for this process by evaluating nuclear factor-κB (NF-κB) and c-Jun N-terminal kinase (JNK) pathway involvement in Huh-7 cells...
April 27, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29699060/contrast-enhanced-endoscopic-ultrasound-for-differentially-diagnosing-autoimmune-pancreatitis-and-pancreatic-cancer
#10
Min Keun Cho, Sung-Hoon Moon, Tae Jun Song, Raymond E Kim, Dong Wook Oh, Do Hyun Park, Sang Soo Lee, Dong Wan Seo, Sung Koo Lee, Myung-Hwan Kim
Background/Aims: Differentially diagnosing focal-type autoimmune pancreatitis (f-AIP) and pancreatic cancer (PC) is challenging. Contrast-enhanced harmonic endoscopic ultrasound (CEH-EUS) may provide information for differentiating pancreatic masses. In this study, we evaluated the usefulness of CEH-EUS in differentiating f-AIP from PC. Methods: Data were collected prospectively and analyzed on patients who underwent CEH-EUS between May 2014 and May 2015. Eighty consecutive patients were diagnosed with f-AIP or PC...
April 27, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29699059/measuring-intrahepatic-vascular-changes-using-contrast-enhanced-ultrasonography-to-predict-the-prognosis-of-alcoholic-hepatitis-combined-with-cirrhosis-a-prospective-pilot-study
#11
Min Sun Park, Soonchang Hong, Yoo Li Lim, Seong Hee Kang, Soon Koo Baik, Moon Young Kim
Background/Aims: Acute hepatic dysfunction combined with alcoholic hepatitis (AH) in alcoholic cirrhosis is related to hepatic hypo-perfusion secondary to intrahepatic necroinflammation, neoangiogenesis, and shunt. The hepatic vein arrival time (HVAT) assessed by microbubble contrast-enhanced ultrasonography (CEUS) is closely correlated with the severity of intrahepatic changes. We investigated the usefulness of HVAT to predict short-term mortality of AH in cirrhosis. Methods: Thirty-nine patients with alcoholic cirrhosis (27 males) and AH were prospectively enrolled...
April 27, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29588436/long-term-clinical-outcomes-of-endoscopic-submucosal-dissection-in-patients-with-early-gastric-cancer-a-prospective-multicenter-cohort-study
#12
Sang Gyun Kim, Chan Mi Park, Na Rae Lee, Jiyoung Kim, Da Hyun Lyu, Seung-Hee Park, Il Ju Choi, Wan Sik Lee, Seun Ja Park, Jae Jun Kim, Ji Hyun Kim, Chul-Hyun Lim, Joo Young Cho, Gwang Ha Kim, Yong Chan Lee, Hwoon-Yong Jung, Jun Haeng Lee, Hoon Jai Chun, Sang-Yong Seol
Background/Aims: Endoscopic submucosal dissection (ESD) has been regarded as a curative treatment for early gastric cancer (EGC) in indicated cases. The aim of this study was to evaluate the nationwide long-term clinical outcomes of ESD for EGC in Korea. Methods: A prospective multicenter cohort study was performed to evaluate the long-term efficacy of ESD for EGC within pre-defined indications at 12 institutes in Korea. The cases that met the expanded criteria upon pathological review after ESD were followed for 5 years...
March 29, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29588435/factors-associated-with-health-related-quality-of-life-in-korean-patients-with-chronic-hepatitis-c-infection-using-the-sf-36-and-eq-5d
#13
Eun Sun Jang, Young Seok Kim, Kyung-Ah Kim, Youn Jae Lee, Woo Jin Chung, In Hee Kim, Byung Seok Lee, Sook-Hyang Jeong
Background/Aims: This study aimed to describe the Health-related quality of life (HRQoL) outcomes for Korean chronic hepatitis C patients and to investigate the impact of patient and virus-related factors on HRQoL. Methods: HRQoL was assessed in 235 HCV-infected patients from 7 nationwide tertiary hospital, including those with liver cirrhosis and hepatocellular carcinoma (HCC), using the Shor-Form 36 (SF-36) version 2 and the European quality of life questionnaire-5 dimensions (EQ-5D-3L)...
March 29, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29558791/comparison-of-tight-junction-protein-related-gene-mrna-expression-levels-between-male-and-female-gastroesophageal-reflux-disease-patients
#14
Jin Joo Kim, Nayoung Kim, Ji Hyun Park, Young Sun Kim, Sun Min Lee, Dong Ho Lee, Hyun Chae Jung
Background/Aims: Male predominance has been observed in the erosive reflux disease (ERD), but reverse finding in nonerosive reflux disease (NERD). This suggests sex-specific medicine approach is needed but its mechanism is remained to be elucidated. We aimed to compare clinical characteristics and mRNA expression levels of tight junction-related proteins between male and female gastroesophageal reflux disease (GERD) patients. Methods: Sixteen healthy controls, 45 ERD, and 14 NERD patients received upper endoscopies and completed questionnaires...
March 21, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29724089/-latent-gastric-cancer-after-eradicating-helicobacter-pylori
#15
LETTER
Yoshiharu Uno
No abstract text is available yet for this article.
May 15, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29724088/the-bleeding-risk-after-endoscopic-ultrasound-guided-fine-needle-aspiration-in-patients-taking-antithrombotic-agents-is-not-negligible
#16
EDITORIAL
Dong Kee Jang, Sang Hyub Lee
No abstract text is available yet for this article.
May 15, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29724087/inflammatory-parameters-as-available-prognostic-factors-for-pancreatic-cancer-after-chemoradiotherapy
#17
EDITORIAL
Chang Min Cho
No abstract text is available yet for this article.
May 15, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29724086/the-long-term-effect-of-early-anti-tumor-necrosis-factor-on-restoration-of-growth-in-pediatric-crohn-s-disease
#18
EDITORIAL
Jung Ok Shim, Yoon Tae Jeen
No abstract text is available yet for this article.
May 15, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29724085/endoscopic-resection-of-gastric-cancer-caused-by-adenoma
#19
EDITORIAL
Seung Yong Shin, Jie-Hyun Kim
No abstract text is available yet for this article.
May 15, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29482314/fecal-immunochemical-test-and-fecal-calprotectin-measurement-are-noninvasive-monitoring-tools-for-predicting-endoscopic-activity-in-patients-with-ulcerative-colitis
#20
EDITORIAL
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