journal
MENU ▼
Read by QxMD icon Read
search

Neural Regeneration Research

journal
https://www.readbyqxmd.com/read/28400818/hyperbaric-oxygen-preconditioning-improves-postoperative-cognitive-dysfunction-by-reducing-oxidant-stress-and-inflammation
#1
REVIEW
Zhi-Xin Gao, Jin Rao, Yuan-Hai Li
Postoperative cognitive dysfunction is a crucial public health issue that has been increasingly studied in efforts to reduce symptoms or prevent its occurrence. However, effective advances remain lacking. Hyperbaric oxygen preconditioning has proved to protect vital organs, such as the heart, liver, and brain. Recently, it has been introduced and widely studied in the prevention of postoperative cognitive dysfunction, with promising results. However, the neuroprotective mechanisms underlying this phenomenon remain controversial...
February 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28400817/nonhuman-primate-models-of-focal-cerebral-ischemia
#2
REVIEW
Jingjing Fan, Yi Li, Xinyu Fu, Lijuan Li, Xiaoting Hao, Shasha Li
Rodents have been widely used in the production of cerebral ischemia models. However, successful therapies have been proven on experimental rodent stroke model, and they have often failed to be effective when tested clinically. Therefore, nonhuman primates were recommended as the ideal alternatives, owing to their similarities with the human cerebrovascular system, brain metabolism, grey to white matter ratio and even their rich behavioral repertoire. The present review is a thorough summary of ten methods that establish nonhuman primate models of focal cerebral ischemia; electrocoagulation, endothelin-1-induced occlusion, microvascular clip occlusion, autologous blood clot embolization, balloon inflation, microcatheter embolization, coil embolization, surgical suture embolization, suture, and photochemical induction methods...
February 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28400816/the-cortical-activation-pattern-during-bilateral-arm-raising-movements
#3
Sung Ho Jang, Jung Pyo Seo, Seung-Hyun Lee, Sang-Hyun Jin, Sang Seok Yeo
Bilateral arm raising movements have been used in brain rehabilitation for a long time. However, no study has been reported on the effect of these movements on the cerebral cortex. In this study, using functional near infrared spectroscopy (fNIRS), we attempted to investigate cortical activation generated during bilateral arm raising movements. Ten normal subjects were recruited for this study. fNIRS was performed using an fNIRS system with 49 channels. Bilateral arm raising movements were performed in sitting position at the rate of 0...
February 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28400815/delayed-treatment-of-secondary-degeneration-following-acute-optic-nerve-transection-using-a-combination-of-ion-channel-inhibitors
#4
Nathanael J Yates, Marcus K Giacci, Ryan L O'Hare Doig, Wissam Chiha, Bethany E Ashworth, Jade Kenna, Carole A Bartlett, Melinda Fitzgerald
Studies have shown that a combined application of several ion channel inhibitors immediately after central nervous system injury can inhibit secondary degeneration. However, for clinical use, it is necessary to determine how long after injury the combined treatment of several ion channel inhibitors can be delayed and efficacy maintained. In this study, we delivered Ca(2+) entry-inhibiting P2X7 receptor antagonist oxidized-ATP and AMPA receptor antagonist YM872 to the optic nerve injury site via an iPRECIO(@) pump immediately, 6 hours, 24 hours and 7 days after partial optic nerve transection surgery...
February 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28400814/neuroprotective-effect-of-the-chinese-medicine-tiantai-no-1-and-its-molecular-mechanism-in-the-senescence-accelerated-mouse-prone-8
#5
Ying-Hong Li, Xu-Sheng Wang, Xiao-Lin Chen, Yu Jin, Hong-Bo Chen, Xiu-Qin Jia, Yong-Feng Zhang, Zheng-Zhi Wu
Tiantai No. 1, a Chinese medicine predominantly composed of powdered Rhizoma Gastrodiae, Radix Ginseng, and Ginkgo leaf at a ratio of 2:1:2 and dissolved in pure water, is neuroprotective in animal models of various cognitive disorders, but its molecular mechanism remains unclear. We administered Tiantai No. 1 intragastrically to senescence-accelerated mouse prone 8 (SAMP8) mice (a model of Alzheimer's disease) at doses of 50, 100 or 150 mg/kg per day for 8 weeks and evaluated their behavior in the Morris water maze and expression of Alzheimer's disease-related proteins in the brain...
February 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28400813/adenyl-cyclase-activator-forskolin-protects-against-huntington-s-disease-like-neurodegenerative-disorders
#6
Sidharth Mehan, Shaba Parveen, Sanjeev Kalra
Long term suppression of succinate dehydrogenase by selective inhibitor 3-nitropropionic acid has been used in rodents to model Huntington's disease where mitochondrial dysfunction and oxidative damages are primary pathological hallmarks for neuronal damage. Improvements in learning and memory abilities, recovery of energy levels, and reduction of excitotoxicity damage can be achieved through activation of Adenyl cyclase enzyme by a specific phytochemical forskolin. In this study, intraperitoneal administration of 10 mg/kg 3-nitropropionic acid for 15 days in rats notably reduced body weight, worsened motor cocordination (grip strength, beam crossing task, locomotor activity), resulted in learning and memory deficits, greatly increased acetylcholinesterase, lactate dehydrogenase, nitrite, and malondialdehyde levels, obviously decreased adenosine triphosphate, succinate dehydrogenase, superoxide dismutase, catalase, and reduced glutathione levels in the striatum, cortex and hippocampus...
February 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28400812/edaravone-protects-against-oxygen-glucose-serum-deprivation-restoration-induced-apoptosis-in-spinal-cord-astrocytes-by-inhibiting-integrated-stress-response
#7
Bin Dai, Ting Yan, Yi-Xing Shen, You-Jia Xu, Hai-Bin Shen, Dong Chen, Jin-Rong Wang, Shuang-Hua He, Qi-Rong Dong, Ai-Liang Zhang
We previously found that oxygen-glucose-serum deprivation/restoration (OGSD/R) induces apoptosis of spinal cord astrocytes, possibly via caspase-12 and the integrated stress response, which involves protein kinase R-like endoplasmic reticulum kinase (PERK), eukaryotic initiation factor 2-alpha (eIF2α) and activating transcription factor 4 (ATF4). We hypothesized that edaravone, a low molecular weight, lipophilic free radical scavenger, would reduce OGSD/R-induced apoptosis of spinal cord astrocytes. To test this, we established primary cultures of rat astrocytes, and exposed them to 8 hours/6 hours of OGSD/R with or without edaravone (0...
February 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28400811/effect-of-electroacupuncture-on-the-mrna-and-protein-expression-of-rho-a-and-rho-associated-kinase-ii-in-spinal-cord-injury-rats
#8
You-Jiang Min, Li-Li-Qiang Ding, Li-Hong Cheng, Wei-Ping Xiao, Xing-Wei He, Hui Zhang, Zhi-Yun Min, Jia Pei
Electroacupuncture is beneficial for the recovery of spinal cord injury, but the underlying mechanism is unclear. The Rho/Rho-associated kinase (ROCK) signaling pathway regulates the actin cytoskeleton by controlling the adhesive and migratory behaviors of cells that could inhibit neurite regrowth after neural injury and consequently hinder the recovery from spinal cord injury. Therefore, we hypothesized electroacupuncture could affect the Rho/ROCK signaling pathway to promote the recovery of spinal cord injury...
February 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28400810/tanshinone-iia-improves-functional-recovery-in-spinal-cord-injury-induced-lower-urinary-tract-dysfunction
#9
Yong-Dong Yang, Xing Yu, Xiu-Mei Wang, Xiao-Hong Mu, Feng He
Tanshinone IIA, extracted from Salvia miltiorrhiza Bunge, exerts neuroprotective effects through its anti-inflammatory, anti-oxidative and anti-apoptotic properties. This study intravenously injected tanshinone IIA 20 mg/kg into rat models of spinal cord injury for 7 consecutive days. Results showed that tanshinone IIA could reduce the inflammation, edema as well as compensatory thickening of the bladder tissue, improve urodynamic parameters, attenuate secondary injury, and promote spinal cord regeneration...
February 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28400809/correction-future-directions-for-using-estrogen-receptor-agonists-in-the-treatment-of-acute-and-chronic-spinal-cord-injury
#10
Swapan K Ray, Supriti Samantaray, Naren L Banik
[This corrects the article on p. 1418 in vol. 11, PMID: 27857741.].
February 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28400808/dcdc2-gene-polymorphisms-are-associated-with-developmental-dyslexia-in-chinese-uyghur-children
#11
Yun Chen, Hua Zhao, Yi-Xin Zhang, Peng-Xiang Zuo
Developmental dyslexia is a complex reading and writing disorder with strong genetic components. In previous genetic studies about dyslexia, a number of candidate genes have been identified. These include DCDC2, which has repeatedly been associated with developmental dyslexia in various European and American populations. However, data regarding this relationship are varied according to population. The Uyghur people of China represent a Eurasian population with an interesting genetic profile. Thus, this group may provide useful information about the association between DCDC2 gene polymorphisms and dyslexia...
February 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28400807/modulatory-effects-of-acupuncture-on-brain-networks-in-mild-cognitive-impairment-patients
#12
Ting-Ting Tan, Dan Wang, Ju-Ke Huang, Xiao-Mei Zhou, Xu Yuan, Jiu-Ping Liang, Liang Yin, Hong-Liang Xie, Xin-Yan Jia, Jiao Shi, Fang Wang, Hao-Bo Yang, Shang-Jie Chen
Functional magnetic resonance imaging has been widely used to investigate the effects of acupuncture on neural activity. However, most functional magnetic resonance imaging studies have focused on acute changes in brain activation induced by acupuncture. Thus, the time course of the therapeutic effects of acupuncture remains unclear. In this study, 32 patients with amnestic mild cognitive impairment were randomly divided into two groups, where they received either Tiaoshen Yizhi acupuncture or sham acupoint acupuncture...
February 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28400806/a-protease-activated-receptor-1-antagonist-protects-against-global-cerebral-ischemia-reperfusion-injury-after-asphyxial-cardiac-arrest-in-rabbits
#13
Jing-Ning Yang, Jun Chen, Min Xiao
Cerebral ischemia/reperfusion injury is partially mediated by thrombin, which causes brain damage through protease-activated receptor 1 (PAR1). However, the role and mechanisms underlying the effects of PAR1 activation require further elucidation. Therefore, the present study investigated the effects of the PAR1 antagonist SCH79797 in a rabbit model of global cerebral ischemia induced by cardiac arrest. SCH79797 was intravenously administered 10 minutes after the model was established. Forty-eight hours later, compared with those administered saline, rabbits receiving SCH79797 showed markedly decreased neuronal damage as assessed by serum neuron specific enolase levels and less neurological dysfunction as determined using cerebral performance category scores...
February 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28400805/3-daidzein-sulfonate-sodium-improves-mitochondrial-functions-after-cerebral-ischemia-reperfusion-injury
#14
Wa Yuan, Qin Chen, Jing Zeng, Hai Xiao, Zhi-Hua Huang, Xiao Li, Qiong Lei
3'-Daidzein sulfonate sodium is a new synthetic water-soluble compound derived from daidzein (an active ingredient of the kudzu vine root). It has been shown to have a protective effect on cerebral ischemia/reperfusion injury in rats. We plan to study the mechanism of its protective effect. 3'-Daidzein sulfonate sodium was injected in rats after cerebral ischemia/reperfusion injury. Results showed that 3'-daidzein sulfonate sodium significantly reduced mitochondrial swelling, significantly elevated the mitochondrial membrane potential, increased mitochondrial superoxide dismutase and glutathione peroxidase activities, and decreased mitochondrial malondialdehyde levels...
February 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28400804/electroacupuncture-induced-neuroprotection-against-focal-cerebral-ischemia-in-the-rat-is-mediated-by-adenosine-a1-receptors
#15
Qin-Xue Dai, Wu-Jun Geng, Xiu-Xiu Zhuang, Hong-Fa Wang, Yun-Chang Mo, He Xin, Jiang-Fan Chen, Jun-Lu Wang
The activation of adenosine A1 receptors is important for protecting against ischemic brain injury and pretreatment with electroacupuncture has been shown to mitigate ischemic brain insult. The aim of this study was to test whether the adenosine A1 receptor mediates electroacupuncture pretreatment-induced neuroprotection against ischemic brain injury. We first performed 30 minutes of electroacupuncture pretreatment at the Baihui acupoint (GV20), delivered with a current of 1 mA, a frequency of 2/15 Hz, and a depth of 1 mm...
February 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28400803/pretreated-quercetin-protects-gerbil-hippocampal-ca1-pyramidal-neurons-from-transient-cerebral-ischemic-injury-by-increasing-the-expression-of-antioxidant-enzymes
#16
Bai Hui Chen, Joon Ha Park, Ji Hyeon Ahn, Jeong Hwi Cho, In Hye Kim, Jae Chul Lee, Moo-Ho Won, Choong-Hyun Lee, In Koo Hwang, Jong-Dai Kim, Il Jun Kang, Jun Hwi Cho, Bich Na Shin, Yang Hee Kim, Yun Lyul Lee, Seung Min Park
Quercetin (QE; 3,5,7,3',4'-pentahydroxyflavone), a well-known flavonoid, has been shown to prevent against neurodegenerative disorders and ischemic insults. However, few studies are reported regarding the neuroprotective mechanisms of QE after ischemic insults. Therefore, in this study, we investigated the effects of QE on ischemic injury and the expression of antioxidant enzymes in the hippocampal CA1 region of gerbils subjected to 5 minutes of transient cerebral ischemia. QE was pre-treated once daily for 15 days before ischemia...
February 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28400802/pde5-inhibitors-promote-recovery-of-peripheral-neuropathy-in-diabetic-mice
#17
Lei Wang, Michael Chopp, Zheng Gang Zhang
No abstract text is available yet for this article.
February 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28400801/neonatal-seizures-and-disruption-to-neurotransmitter-systems
#18
Stephanie M Miller, Kate Goasdoue, S Tracey Björkman
No abstract text is available yet for this article.
February 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28400800/mitochondria-in-the-context-of-parkinson-s-disease
#19
Patricia Villacé, Rosa M Mella, Danel Kortazar
No abstract text is available yet for this article.
February 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28400799/targeting-the-guanine-based-purinergic-system-in-alzheimer-s-disease
#20
Débora Lanznaster, Carla I Tasca
No abstract text is available yet for this article.
February 2017: Neural Regeneration Research
journal
journal
41745
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"