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Neural Regeneration Research

Sung Ho Jang, Seong Ho Kim, Sang Seok Yeo
No abstract text is available yet for this article.
June 2018: Neural Regeneration Research
Ling-Xin Li, Ming-Ming Zhang, Yin Zhang, Jing He
Objective: To evaluate the efficacy and safety of acupuncture therapy for children with cerebral palsy. Data Sources: We conducted electronic searches of PUBMED (1950/2017), EMBASE (1974/2017), ScienceDirect (1986/2017), Academic Source Premier (1887/2017), the Cochrane Library (Issue 4, April 2017), Science Citation Index Expanded (1900/2017), China National Knowledge Infrastructure (1915/2017), China Biological Medicine (1990/2017-04), WanFang (1980/2017), VIP (1989/2017), and Chinese Science Citation Database (1989/2017)...
June 2018: Neural Regeneration Research
Chuan Qin, Wen-Hao Zhang, De-Gang Yang, Ming-Liang Yang, Liang-Jie Du, Jian-Jun Li
Objective: To investigate the effects of myelotomy on locomotor recovery in rats subjected to spinal cord injury. Data Sources: Electronic databases including PubMed, Science Citation Index, Cochrane Library, China National Knowledge Infrastructure, Chinese Journals Full-text Database, China Biology Medicine disc, and Wanfang Database were searched to retrieve related studies published before September 2017. The MeSH terms (the Medical Subject Headings) such as "myelotomy", "spinal cord injuries", "rats", "randomized controlled trial" and all related entry terms were searched...
June 2018: Neural Regeneration Research
Ming Zhao, Jia-Yi Chen, Yu-Dong Chu, Ya-Bin Zhu, Lin Luo, Shi-Zhong Bu
Objective: To evaluate the efficacy of α-lipoic acid (ALA) plus epalrestat combination therapy in the treatment of diabetic peripheral neuropathy (DPN). Data Sources: The electronic databases of PubMed, Medline, Embase, the Cochrane Library, the Chinese National Knowledge Infrastructure, the Wanfang Database and the Chinese Biomedical Database were used to retrieve relevant studies without language restrictions. The search was conducted from the inception of each database to 7 October 2016...
June 2018: Neural Regeneration Research
Ming Hao, Yu Liu, Ping Chen, Hong Jiang, Hong-Yu Kuang
Astragaloside IV is the main active compound of Astragalus membranaceus. Astragaloside IV has strong anti-oxidative activities and protective effects against progression of peripheral neuropathy. In this study, we determined whether astragaloside IV protects retinal ganglion cells (RGC) from oxidative stress injury using the rat RGC-5 cell line. Hydrogen peroxide (H2 O2 ) was used to induce oxidative stress injury, with the protective effect of astragaloside IV examined. Cell Counting Kit-8 and 4',6-diamidino-2-phenylindole staining showed that astragaloside IV increased cell survival rate and decreased apoptotic cell number...
June 2018: Neural Regeneration Research
Sara H Mokhtar, Min Joung Kim, Kylie A Magee, Pei Mun Aui, Speros Thomas, Maha M Bakhuraysah, Amani A Alrehaili, Jae Young Lee, David L Steer, Rachel Kenny, Catriona McLean, Michael F Azari, Antonis Birpanagos, Ewlina Lipiec, Philip Heraud, Bayden Wood, Steven Petratos
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by accumulation of amyloid plaques and neurofibrillary tangles. Prior to the development of these characteristic pathological hallmarks of AD, anterograde axonal transport is impaired. However, the key proteins that initiate these intracellular impairments remain elusive. The collapsin response mediator protein-2 (CRMP-2) plays an integral role in kinesin-1-dependent axonal transport and there is evidence that phosphorylation of CRMP-2 releases kinesin-1...
June 2018: Neural Regeneration Research
Wei-Wei Wang, Ye-Chen Lu, Wei-Jun Tang, Jun-Hai Zhang, Hua-Ping Sun, Xiao-Yuan Feng, Han-Qiu Liu
Research on brain function after brachial plexus injury focuses on local cortical functional reorganization, and few studies have focused on brain networks after brachial plexus injury. Changes in brain networks may help understanding of brain plasticity at the global level. We hypothesized that topology of the global cerebral resting-state functional network changes after unilateral brachial plexus injury. Thus, in this cross-sectional study, we recruited eight male patients with unilateral brachial plexus injury (right handedness, mean age of 27...
June 2018: Neural Regeneration Research
Chen Chen, Guang-Chao Bai, Hong-Liang Jin, Kun Lei, Kuan-Xin Li
After spinal cord injury, the number of glial cells and motor neurons expressing bone morphogenetic protein 7 (BMP7) increases, indicating that upregulation of BMP7 can promote nerve repair. We, therefore, tested whether direct injection of BMP7 into acutely injured rat spinal cord can affect neurological recovery. Allen's impactor was used to create spinal cord injury at T10 . The injury site was then injected with 50 ng BMP7 (BMP7 group) or physiological saline (control group) for 7 consecutive days. Electrophysiological examination showed that the amplitude of N1 in motor evoked potentials (MEP) decreased after spinal cord injury...
June 2018: Neural Regeneration Research
Bruna Dos Santos Ramalho, Fernanda Martins de Almeida, Conrado Mendonça Sales, Silmara de Lima, Ana Maria Blanco Martinez
In spite of advances in surgical care and rehabilitation, the consequences of spinal cord injury (SCI) are still challenging. Several experimental therapeutic strategies have been studied in the SCI field, and recent advances have led to the development of therapies that may act on the inhibitory microenvironment. Assorted lineages of stem cells are considered a good treatment for SCI. This study investigated the effect of systemic transplantation of mesenchymal stem cells (MSCs) in a compressive SCI model...
June 2018: Neural Regeneration Research
Sarah E Walker, Rachel Nottrodt, Lucas Maddalena, Christopher Carter, Gaynor E Spencer, Robert L Carlone
Some adult vertebrate species, such as newts, axolotls and zebrafish, have the ability to regenerate their central nervous system (CNS). However, the factors that establish a permissive CNS environment for correct morphological and functional regeneration in these species are not well understood. Recent evidence supports a role for retinoid signaling in the intrinsic ability of neurons, in these regeneration-competent species, to regrow after CNS injury. Previously, we demonstrated that a specific retinoic acid receptor (RAR) subtype, RARβ, mediates the effects of endogenous retinoic acid (RA) on neuronal growth and guidance in the adult newt CNS after injury...
June 2018: Neural Regeneration Research
Shuai An, Yong-Fang Zhao, Xiao-Ying Lü, Zhi-Gong Wang
The electrical excitability of neural networks is influenced by different environmental factors. Effective and simple methods are required to objectively and quantitatively evaluate the influence of such factors, including variations in temperature and pharmaceutical dosage. The aim of this paper was to introduce 'the voltage threshold measurement method', which is a new method using microelectrode arrays that can quantitatively evaluate the influence of different factors on the electrical excitability of neural networks...
June 2018: Neural Regeneration Research
Wen-Juan Fan, Ming-Chao Yan, Lai Wang, Yi-Zheng Sun, Jin-Bo Deng, Jie-Xin Deng
Synapses are key structures in neural networks, and are involved in learning and memory in the central nervous system. Investigating synaptogenesis and synaptic aging is important in understanding neural development and neural degeneration in diseases such as Alzheimer disease and Parkinson's disease. Our previous study found that synaptogenesis and synaptic maturation were harmonized with brain development and maturation. However, synaptic damage and loss in the aging cerebellum are not well understood. This study was designed to investigate the occurrence of synaptic aging in the cerebellum by observing the ultrastructural changes of dendritic spines and synapses in cerebellar Purkinje cells of aging mice...
June 2018: Neural Regeneration Research
Rui-Qing Li, Ming-Yue Wan, Jing Shi, Hui-Ling Wang, Fei-Lai Liu, Cheng-Mei Liu, Jin Huang, Ren-Chao Liu, Le Ma, Xiao-Dong Feng
Catgut implantation at acupoints has been shown to alleviate spasticity after stroke in rats. However, the underlying mechanisms are poorly understood. In this study, we used the rat middle cerebral artery occlusion model of stroke. Three days after surgery, absorbable surgical catgut sutures were implanted at Dazhui (GV14), Jizhong (GV6), Houhui, Guanyuan (CV4) and Zhongwan (CV12). The Zea Longa score was used to assess neurological function. The Modified Ashworth Scale was used to evaluate muscle tension...
June 2018: Neural Regeneration Research
Wei-Cherng Hsu, Chun-Hsien Yu, Woon-Man Kung, Kuo-Feng Huang
Surgical brain injury may result in irreversible neurological deficits. Our previous report showed that partial regeneration of a traumatic brain lesion is achieved by implantation of collagen glycosaminoglycan (CGM). Matrix metalloproteinases (MMPs) may play an important role in neurogenesis but there is currently a lack of studies displaying the relationship between the stimulation of MMPs and neurogenesis after collagen glycosaminoglycan implantation following surgical brain trauma. The present study was carried out to further examine the expression of MMP2 and MMP9 after implantation of collagen glycosaminoglycan (CGM) following surgical brain trauma...
June 2018: Neural Regeneration Research
Bo Du, Ai-Jun Shan, Yu-Juan Zhang, Jin Wang, Kai-Wen Peng, Xian-Liang Zhong, Yu-Ping Peng
The mortality rate of acute severe intraventricular hematoma is extremely high, and the rate of disability in survivors is high. Intraventricular hematoma has always been a difficult problem for clinical treatment. Although minimally invasive endoscopic hematoma evacuation is widely used to treat this disease, the technique still has room for improvement. Equipment for the intra-neuroendoscopic technique (INET) consists of two of our patented inventions: a transparent sheath (Patent No. ZL 200820046232.0) and a hematoma aspirator (Patent No...
June 2018: Neural Regeneration Research
Jin-Feng Wang, Zhi-Gang Mei, Yang Fu, Song-Bai Yang, Shi-Zhong Zhang, Wei-Feng Huang, Li Xiong, Hua-Jun Zhou, Wei Tao, Zhi-Tao Feng
Puerarin suppresses autophagy to alleviate cerebral ischemia/reperfusion injury, and accumulating evidence indicates that the AMPK-mTOR signaling pathway regulates the activation of the autophagy pathway through the coordinated phosphorylation of ULK1. In this study, we investigated the mechanisms underlying the neuroprotective effect of puerarin and its role in modulating autophagy via the AMPK-mTOR-ULK1 signaling pathway in the rat middle cerebral artery occlusion model of cerebral ischemia/reperfusion injury...
June 2018: Neural Regeneration Research
Shenandoah Robinson, Frances J Northington, Lauren L Jantzie
No abstract text is available yet for this article.
June 2018: Neural Regeneration Research
Liam Chen
No abstract text is available yet for this article.
June 2018: Neural Regeneration Research
Solomon Habtemariam
No abstract text is available yet for this article.
June 2018: Neural Regeneration Research
Hiroshi Nakagawa, Masahiko Takada
No abstract text is available yet for this article.
June 2018: Neural Regeneration Research
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