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Neural Regeneration Research

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https://www.readbyqxmd.com/read/28616042/cerebral-mechanism-of-puncturing-at-he-mu-point-combination-for-functional-dyspepsia-study-protocol-for-a-randomized-controlled-parallel-trial
#1
Shuai Yin, Yuan Chen, Du Lei, Rui-Rui Sun, Ting-Ting Ma, Pei-Min Feng, Zhao-Xuan He, Xue-Ling Suo, Pei-Hong Ma, Yu-Zhu Qu, Ke Qiu, Miao-Miao Jing, Qi-Yong Gong, Fan-Rong Liang, Jiao Chen, Fang Zeng
Acupuncture is widely used to treat functional dyspepsia with satisfactory outcomes. Combination of the He and Mu acupoints is commonly used and has a synergistic effect on functional dyspepsia; however, its underlying mechanisms remain unclear. Therefore, a randomized controlled parallel clinical trial is currently underway at Chengdu University of Traditional Chinese Medicine, China. This trial is designed to explore the efficacy of and central responses to the He-Mu point combination in patients with functional dyspepsia using functional magnetic resonance imaging...
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28616041/efficacy-of-intraorbital-electroacupuncture-for-diabetic-abducens-nerve-palsy-study-protocol-for-a-prospective-single-center-randomized-controlled-trial
#2
Ling-Yun Zhou, Xue-Mei Li, Tie-Juan Liu, Xiao-Jie Ji, Ming Zhao, Chang Su, Ji-Chao Liu, Jiang-Yun Sun
Abducens nerve palsy (ANP) is commonly seen in patients with diabetes mellitus. The validity of acupuncture as a traditional Chinese medicine method in peripheral nerve repair is well established. However, its efficacy in randomized controlled trials remains unclear. Herein, we designed a protocol for a prospective, single-center, randomized controlled trial to investigate the effect of intraorbital electroacupuncture on diabetic ANP. We plan to recruit 60 patients with diabetic ANP, and randomly divide them into treatment and control groups...
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28616040/stem-cell-transplantation-for-spinal-cord-injury-a-meta-analysis-of-treatment-effectiveness-and-safety
#3
Xiao Fan, Jin-Zhao Wang, Xiao-Min Lin, Li Zhang
OBJECTIVE: The aim of this study was to evaluate the effectiveness and safety of stem cell transplantation for spinal cord injury (SCI). DATA SOURCES: PubMed, EMBASE, Cochrane, China National Knowledge Infrastructure, China Science and Technology Journal, Wanfang, and SinoMed databases were systematically searched by computer to select clinical randomized controlled trials using stem cell transplantation to treat SCI, published between each database initiation and July 2016...
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28616039/the-brain-activation-pattern-of-the-medial-temporal-lobe-during-chewing-gum-a-functional-mri-study
#4
Youn-Hee Choi, Woo Hyuk Jang, Sang-Uk Im, Keun-Bae Song, Hee-Kyung Lee, Han Do Lee, You Sung Seo, Sung Ho Jang
No abstract text is available yet for this article.
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28616038/electroacupuncture-at-fengchi-gb20-inhibits-calcitonin-gene-related-peptide-expression-in-the-trigeminovascular-system-of-a-rat-model-of-migraine
#5
Luo-Peng Zhao, Lu Liu, Pei Pei, Zheng-Yang Qu, Yu-Pu Zhu, Lin-Peng Wang
Most migraine patients suffer from cutaneous allodynia; however, the underlying mechanisms are unclear. Calcitonin gene-related peptide (CGRP) plays an important role in the pathophysiology of migraine, and it is therefore, a potential therapeutic target for treating the pain. In the present study, a rat model of conscious migraine, induced by repeated electrical stimulation of the superior sagittal sinus, was established and treated with electroacupuncture at Fengchi (GB20) (depth of 2-3 mm, frequency of 2/15 Hz, intensity of 0...
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28616037/correlation-between-photoreceptor-injury-regeneration-and-behavior-in-a-zebrafish-model
#6
Ya-Jie Wang, Shi-Jiao Cai, Jian-Lin Cui, Yang Chen, Xin Tang, Yu-Hao Li
Direct exposure to intensive visible light can lead to solar retinopathy, including macular injury. The signs and symptoms include central scotoma, metamorphopsia, and decreased vision. However, there have been few studies examining retinal injury due to intensive light stimulation at the cellular level. Neural network arrangements and gene expression patterns in zebrafish photoreceptors are similar to those observed in humans, and photoreceptor injury in zebrafish can induce stem cell-based cellular regeneration...
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28616036/correlation-between-white-matter-damage-and-gray-matter-lesions-in-multiple-sclerosis-patients
#7
Xue-Mei Han, Hong-Ji Tian, Zheng Han, Ce Zhang, Ying Liu, Jie-Bing Gu, Rohit Bakshi, Xia Cao
We observed the characteristics of white matter fibers and gray matter in multiple sclerosis patients, to identify changes in diffusion tensor imaging fractional anisotropy values following white matter fiber injury. We analyzed the correlation between fractional anisotropy values and changes in whole-brain gray matter volume. The participants included 20 patients with relapsing-remitting multiple sclerosis and 20 healthy volunteers as controls. All subjects underwent head magnetic resonance imaging and diffusion tensor imaging...
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28616035/neuroprotective-effects-of-activin-a-on-endoplasmic-reticulum-stress-mediated-apoptotic-and-autophagic-pc12-cell-death
#8
Long-Xing Xue, Hong-Yu Liu, Yang Cui, Yue Dong, Jiao-Qi Wang, Qiu-Ye Ji, Jin-Ting He, Min Yao, Ying-Ying Wang, Yan-Kun Shao, Jing Mang, Zhong-Xin Xu
Activin A, a member of the transforming growth factor-beta superfamily, plays a neuroprotective role in multiple neurological diseases. Endoplasmic reticulum (ER) stress-mediated apoptotic and autophagic cell death is implicated in a wide range of diseases, including cerebral ischemia and neurodegenerative diseases. Thapsigargin was used to induce PC12 cell death, and Activin A was used for intervention. Our results showed that Activin A significantly inhibited morphological changes in thapsigargin-induced apoptotic cells, and the expression of apoptosis-associated proteins [cleaved-caspase-12, C/EBP homologous protein (CHOP) and cleaved-caspase-3] and biomarkers of autophagy (Beclin-1 and light chain 3), and downregulated the expression of thapsigargin-induced ER stress-associated proteins [inositol requiring enzyme-1 (IRE1), tumor necrosis factor receptor-associated factor 2 (TRAF2), apoptosis signal-regulating kinase 1 (ASK1), c-Jun N-terminal kinase (JNK) and p38]...
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28616034/acupuncture-with-reinforcing-and-reducing-twirling-manipulation-inhibits-hippocampal-neuronal-apoptosis-in-spontaneously-hypertensive-rats
#9
Juan Lu, Yan Guo, Chang-Qing Guo, Xue-Min Shi, Ning-Yu Du, Rui-Li Zhao, Wen-Ping Du, Jing-Rong Liang, Shi-Peng Zhu, Huan Chen
To observe the effects of different acupuncture manipulations on blood pressure and target organ damage in spontaneously hypertensive rats (SHRs), this study used the reinforcing twirling method (1.5-2-mm depth; rotating needle clockwise for 360° and then counter clockwise for 360°, with the thumb moving heavily forward and gently backward, 60 times per minute for 1 minute, and retaining needle for 9 minutes), the reducing twirling method (1.5-2-mm depth; rotating needle counter clockwise for 360° and then clockwise for 360°, with the thumb moving heavily backward and gently forward, 60 times per minute for 1 minute, and retaining needle for 9 minutes), and the needle retaining method (1...
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28616033/exercise-induced-muscle-fatigue-in-the-unaffected-knee-joint-and-its-influence-on-postural-control-and-lower-limb-kinematics-in-stroke-patients
#10
Sun Wook Park, Sung Min Son, Na Kyung Lee
This study aimed to investigate the effects of exercise-induced muscle fatigue in the unaffected knee joint on postural control and kinematic changes in stroke patients. Forty participants (20 stroke patients, 20 age-matched healthy participants) were recruited. To induce fatigue, maximum voluntary isometric contractions were performed in the unaffected knee joint in a Leg Extension Rehab exercise machine using the pneumatic resistance. We measured static and dynamic balance and lower-limb kinematics during gait...
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28616032/dose-dependent-neuroprotective-effect-of-enoxaparin-on-cold-induced-traumatic-brain-injury
#11
Ilknur Keskin, M Yalcin Gunal, Nilufer Ayturk, Ulkan Kilic, Mehmet Ozansoy, Ertugrul Kilic
Recent evidence exists that enoxaparin can reduce brain injury because of its anticoagulant activity. To investigate the potential therapeutic effect of enoxaparin on cold-induced traumatic brain injury, at 20 minutes after modeling, male BALB/c mouse models of cold-induced traumatic brain injury were intraperitoneally administered 3 and 10 mg/kg enoxaparin or isotonic saline solution. Twenty-four hours later, enoxaparin at 10 mg/kg greatly reduced infarct volume, decreased cell apoptosis in the cortex and obviously increased serum level of total antioxidant status...
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28616031/polyethylene-glycol-restores-axonal-conduction-after-corpus-callosum-transection
#12
Ravinder Bamba, D Colton Riley, Richard B Boyer, Alonda C Pollins, R Bruce Shack, Wesley P Thayer
Polyethylene glycol (PEG) has been shown to restore axonal continuity after peripheral nerve transection in animal models. We hypothesized that PEG can also restore axonal continuity in the central nervous system. In this current experiment, coronal sectioning of the brains of Sprague-Dawley rats was performed after animal sacrifice. 3Brain high-resolution microelectrode arrays (MEA) were used to measure mean firing rate (MFR) and peak amplitude across the corpus callosum of the ex-vivo brain slices. The corpus callosum was subsequently transected and repeated measurements were performed...
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28616030/time-lapse-changes-of-in-vivo-injured-neuronal-substructures-in-the-central-nervous-system-after-low-energy-two-photon-nanosurgery
#13
Zhikai Zhao, Shuangxi Chen, Yunhao Luo, Jing Li, Smaranda Badea, Chaoran Ren, Wutian Wu
There is currently very little research regarding the dynamics of the subcellular degenerative events that occur in the central nervous system in response to injury. To date, multi-photon excitation has been primarily used for imaging applications; however, it has been recently used to selectively disrupt neural structures in living animals. However, understanding the complicated processes and the essential underlying molecular pathways involved in these dynamic events is necessary for studying the underlying process that promotes neuronal regeneration...
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28616029/p2x7-receptor-antagonism-in-amyotrophic-lateral-sclerosis
#14
Ronald Sluyter, Rachael Bartlett, Diane Ly, Justin J Yerbury
No abstract text is available yet for this article.
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28616028/need-for-multiple-biomarkers-to-adjust-parameters-of-closed-loop-deep-brain-stimulation-for-parkinson-s-disease
#15
Takashi Morishita, Tooru Inoue
No abstract text is available yet for this article.
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28616027/the-role-of-motor-network-reorganization-during-rehabilitation
#16
Yue Li, Edmund R Hollis
No abstract text is available yet for this article.
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28616026/antioxidant-induced-reductive-stress-has-untoward-consequences-on-the-brain-microvasculature
#17
David Fisher, Shireen Mentor
No abstract text is available yet for this article.
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28616025/age-at-injury-effects-of-microglial-activation-following-traumatic-brain-injury-implications-for-treatment-strategies
#18
Ramesh Raghupathi, Jimmy W Huh
No abstract text is available yet for this article.
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28616024/chronically-denervated-distal-nerve-stump-inhibits-peripheral-nerve-regeneration
#19
Giulia Ronchi, Stefania Raimondo
No abstract text is available yet for this article.
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28616023/genetically-modifying-transcription-factors-to-promote-cns-axon-regeneration
#20
Saloni T Mehta, John L Bixby, Vance P Lemmon
No abstract text is available yet for this article.
May 2017: Neural Regeneration Research
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