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Neural Regeneration Research

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https://www.readbyqxmd.com/read/30233078/restoration-of-an-injured-lower-dorsal-ascending-reticular-activating-system-in-a-patient-with-intraventricular-hemorrhage
#1
Sung Ho Jang, Sang Seok Yeo
No abstract text is available yet for this article.
November 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30233077/taurine-protects-against-retinal-and-optic-nerve-damage-induced-by-endothelin-1-in-rats-via-antioxidant-effects
#2
Natasha Najwa Nor Arfuzir, Renu Agarwal, Igor Iezhitsa, Puneet Agarwal, Sabrilhakim Sidek, Nafeeza Mohd Ismail
Endothelin-1 (ET-1), a potent vasoconstrictor, is involved in retinal vascular dysregulation and oxidative stress in glaucomatous eyes. Taurine (TAU), a naturally occurring free amino acid, is known for its neuroprotective and antioxidant properties. Hence, we evaluated its neuroprotective properties against ET-1 induced retinal and optic nerve damage. ET-1 was administered intravitreally to Sprague-Dawley rats and TAU was injected as pre-, co- or post-treatment. Animals were euthanized seven days post TAU injection...
November 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30233076/sirt1-facilitates-amyloid-beta-peptide-degradation-by-upregulating-lysosome-number-in-primary-astrocytes
#3
Min-Zhe Li, Liang-Jun Zheng, Jian Shen, Xin-Ya Li, Qi Zhang, Xue Bai, Qing-Song Wang, Jian-Guo Ji
Previous studies have shown that sirtuin 1 (SIRT1) reduces the production of neuronal amyloid beta (Aβ) and inhibits the inflammatory response of glial cells, thereby generating a neuroprotective effect against Aβ neurotoxicity in animal models of Alzheimer's disease. However, the protective effect of SIRT1 on astrocytes is still under investigation. This study established a time point model for the clearance of Aβ in primary astrocytes. Results showed that 12 hours of culture was sufficient for endocytosis of oligomeric Aβ, and 36 hours sufficient for effective degradation...
November 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30233075/cognitive-deficits-and-alzheimer-like-neuropathological-impairments-during-adolescence-in-a-rat-model-of-type-2-diabetes-mellitus
#4
Li Jin, Yi-Pei Li, Qiong Feng, Li Ren, Fang Wang, Guo-Jia Bo, Li Wang
Numerous studies have shown that many patients who suffer from type 2 diabetes mellitus exhibit cognitive dysfunction and neuronal synaptic impairments. Therefore, growing evidence suggests that type 2 diabetes mellitus has a close relationship with occurrence and progression of neurodegeneration and neural impairment in Alzheimer's disease. However, the relationship between metabolic disorders caused by type 2 diabetes mellitus and neurodegeneration and neural impairments in Alzheimer's disease is still not fully determined...
November 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30233074/enriched-environment-elevates-expression-of-growth-associated-protein-43-in-the-substantia-nigra-of-samp8-mice
#5
Zhen-Yun Yuan, Jie Yang, Xiao-Wei Ma, Yan-Yong Wang, Ming-Wei Wang
An enriched environment protects dopaminergic neurons from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neuronal injury, but the underlying mechanism for this is not clear. Growth associated protein-43 (GAP-43) is closely associated with neurite outgrowth and axon regeneration during neural development. We speculate that an enriched environment can reduce damage to dopaminergic neurons by affecting the expression of GAP-43. This study is designed to test this hypothesis. Three-month-old female senescence-accelerated mouse prone 8 (SAMP8) mice were housed for 3 months in an enriched environment or a standard environment...
November 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30233073/-achyranthes-bidentata-polypeptide-protects-dopaminergic-neurons-from-apoptosis-induced-by-rotenone-and-6-hydroxydopamine
#6
Su Peng, Li Xu, Jin-Yu Ma, Xiao-Song Gu, Cheng Sun
It has been well documented that Achyranthes bidentata polypeptides (ABPPs) are potent neuroprotective agents in several types of neurons. However, whether ABPPs protect dopaminergic neurons from apoptosis induced by neurotoxins is still unknown. This study was designed to observe the effect of ABPPk, a purified fraction of ABPPs, on apoptosis of dopaminergic neurons. SH-5YHY cells and primary dopaminergic neurons were pre-treated with ABPPk (25, 50, or 100 ng/mL) for 12 hours. Cells were then exposed to 6-hydroxydopamine (50 or 150 μM) or rotenone (50 or 200 μM) for 36 hours to induce cell apoptosis...
November 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30233072/hyperoside-protects-the-blood-brain-barrier-from-neurotoxicity-of-amyloid-beta-1-42
#7
Chen-Yang Liu, Kuan Bai, Xiao-Hui Liu, Li-Mi Zhang, Gu-Ran Yu
Mounting evidence indicates that amyloid β protein (Aβ) exerts neurotoxicity by disrupting the blood-brain barrier (BBB) in Alzheimer's disease. Hyperoside has neuroprotective effects both in vitro and in vivo against Aβ. Our previous study found that hyperoside suppressed Aβ1-42 -induced leakage of the BBB, however, the mechanism remains unclear. In this study, bEnd.3 cells were pretreated with 50, 200, or 500 µM hyperoside for 2 hours, and then exposed to Aβ1-42 for 24 hours. Cell viability was determined using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay...
November 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30233071/total-brachial-plexus-injury-contralateral-c7-root-transfer-to-the-lower-trunk-versus-the-median-nerve
#8
Ye Jiang, Li Wang, Jie Lao, Xin Zhao
Contralateral C7 (cC7) root transfer to the healthy side is the main method for the treatment of brachial plexus root injury. A relatively new modification of this method involves cC7 root transfer to the lower trunk via the prespinal route. In the current study, we examined the effectiveness of this method using electrophysiological and histological analyses. To this end, we used a rat model of total brachial plexus injury, and cC7 root transfer was performed to either the lower trunk via the prespinal route or the median nerve via a subcutaneous tunnel to repair the injury...
November 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30233070/microencapsulated-schwann-cell-transplantation-inhibits-p2x3-receptor-expression-in-dorsal-root-ganglia-and-neuropathic-pain
#9
Ya-Ling Zhang, De-Jian Chen, Bao-Lin Yang, Tao-Tao Liu, Jia-Juan Li, Xiu-Qi Wang, Guo-Yong Xue, Zeng-Xu Liu
Schwann cell transplantation is a promising method to promote neural repair, and can be used for peripheral nerve protection and myelination. Microcapsule technology largely mitigates immune rejection of transplanted cells. We previously showed that microencapsulated olfactory ensheathing cells can reduce neuropathic pain and we hypothesized that microencapsulated Schwann cells can also inhibit neuropathic pain. Rat Schwann cells were cultured by subculture and then microencapsulated and were tested using a rat chronic constriction injury (CCI) neuropathic pain model...
November 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30233069/a-rapid-micro-magnetic-resonance-imaging-scanning-for-three-dimensional-reconstruction-of-peripheral-nerve-fascicles
#10
Zhi Yao, Li-Wei Yan, Tao Wang, Shuai Qiu, Tao Lin, Fu-Lin He, Ru-Heng Yuan, Xiao-Lin Liu, Jian Qi, Qing-Tang Zhu
The most common methods for three-dimensional reconstruction of peripheral nerve fascicles include histological and radiology techniques. Histological techniques have many drawbacks including an enormous manual workload and poor image registration. Micro-magnetic resonance imaging (Micro-MRI), an emerging radiology technique, has been used to report results in the brain, liver and tumor tissues. However, micro-MRI usage for obtaining intraneural structures has not been reported. The aim of this study was to present a new imaging method for three-dimensional reconstruction of peripheral nerve fascicles by 1 T micro-MRI...
November 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30233068/glial-fibrillary-acidic-protein-levels-are-associated-with-global-histone-h4-acetylation-after-spinal-cord-injury-in-rats
#11
Mayara Ferraz de Menezes, Fabrício Nicola, Ivy Reichert Vital da Silva, Adriana Vizuete, Viviane Rostirola Elsner, Léder Leal Xavier, Carlos Alberto Saraiva Gonçalves, Carlos Alexandre Netto, Régis Gemerasca Mestriner
Emerging evidence has suggested global histone H4 acetylation status plays an important role in neural plasticity. For instance, the imbalance of this epigenetic marker has been hypothesized as a key factor for the development and progression of several neurological diseases. Likewise, astrocytic reactivity - a well-known process that markedly influences the tissue remodeling after a central nervous system injury - is crucial for tissue remodeling after spinal cord injury (SCI). However, the linkage between the above-mentioned mechanisms after SCI remains poorly understood...
November 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30233067/translocator-protein-ligand-yl-ipa08-attenuates-lipopolysaccharide-induced-depression-like-behavior-by-promoting-neural-regeneration
#12
Xiao-Ying Zhang, Li-Ming Zhang, Wei-Dong Mi, Yun-Feng Li
Translocator protein has received attention for its involvement in the pathogenesis of depression. This study assessed the effects of the new translocator protein ligand, YL-IPA08, on alleviating inflammation-induced depression-like behavior in mice and investigated its mechanism of action. Mice were intracerebroventricularly injected with 1, 10, 100 or 1000 ng lipopolysaccharide. The tail-suspension test and the forced swimming test confirmed that 100 ng lipopolysaccharide induced depression-like behavior...
November 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30233066/molecular-mechanism-of-panaxydol-on-promoting-axonal-growth-in-pc12-cells
#13
Wei-Peng Li, Ke Ma, Xiao-Yan Jiang, Rui Yang, Pei-Hua Lu, Bao-Ming Nie, Yang Lu
Nerve growth factor (NGF) promotes axonal growth in PC12 cells primarily by regulating the RTK-RAS-MEK-ERK pathway. Panaxydol, a polyacetylene isolated from Panax notoginseng, can mimic the effects of NGF. Panaxydol promotes neurite outgrowth in PC12 cells, but its molecular mechanism remains unclear. Indeed, although alkynol compounds such as panaxydol can increase intracellular cyclic adenosine 3',5'-monophosphate (cAMP) levels and the ERK inhibitor U0126 inhibits alkynol-induced axonal growth, how pathways downstream of cAMP activate ERK have not been investigated...
November 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30233065/lncrna-snhg12-ameliorates-brain-microvascular-endothelial-cell-injury-by-targeting-mir-199a
#14
Fa-Qing Long, Qing-Jie Su, Jing-Xia Zhou, De-Sheng Wang, Peng-Xiang Li, Chao-Sheng Zeng, Yi Cai
Long non-coding RNAs regulate brain microvascular endothelial cell death, the inflammatory response and angiogenesis during and after ischemia/reperfusion and oxygen-glucose deprivation/reoxygenation (OGD/R) insults. The long non-coding RNA, SNHG12, is upregulated after ischemia/reperfusion and OGD/R in microvascular endothelial cells of the mouse brain. However, its role in ischemic stroke has not been studied. We hypothesized that SNHG12 positively regulates ischemic stroke, and therefore we investigated its mechanism of action...
November 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30233064/microbleeds-in-fronto-subcortical-circuits-are-predictive-of-dementia-conversion-in-patients-with-vascular-cognitive-impairment-but-no-dementia
#15
Yang-Kun Chen, Wei-Min Xiao, Wei Li, Zhuo-Xin Ni, Yong-Lin Liu, Li Xu, Jian-Feng Qu, Chee H Ng, Yu-Tao Xiang
Cerebral small vessel disease (CSVD) is a common etiology of vascular cognitive impairment with no dementia (V-CIND). Studies have revealed that cerebral microbleeds (CMBs), a feature of CSVD, contribute to cognitive impairment. However, the association between CMBs and dementia conversion in individuals with V-CIND is still unclear. Here, we analyzed the predictive role of CMBs in the conversion from V-CIND to dementia in CSVD patients. We recruited and prospectively assessed 85 patients with CSVD and V-CIND...
November 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30233063/symptom-experience-and-symptom-burden-of-patients-following-first-ever-stroke-within-1-year-a-cross-sectional-study
#16
Dan Shi, Zheng Li, Jian Yang, Bang-Zhong Liu, Hui Xia
Symptoms that are multidimensional and concurrent should be assessed from different dimensions and managed together. Few studies have evaluated concurrent and multidimensional symptoms in patients with stroke. Most studies of stroke focused on dysfunctions and complications. We hypothesize that patients with stroke have a heavy symptom burden within 1 year. This study aimed to describe multidimensional and concurrent symptoms within 1 year after stroke. This study recruited 230 patients with stroke from the Rehabilitation Department of Xuhui District Center Hospital of Shanghai and the Shanghai Sunshine Rehabilitation Center in China from March to September 2017...
November 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30233062/effect-of-acoustic-stimuli-in-patients-with-disorders-of-consciousness-a-quantitative-electroencephalography-study
#17
Min Wu, Wang-Xiao Bao, Jie Zhang, Yang-Fan Hu, Jian Gao, Ben-Yan Luo
Auditory stimuli are proposed as beneficial neurorehabilitation methods in patients with disorders of consciousness. However, precise and accurate quantitative indices to estimate their potential effect remain scarce. Fourteen patients were recruited from the Neuro-Rehabilitation Unit of Hangzhou Hospital of Zhejiang Armed Police Corps of China. Altogether, there were seven cases of unresponsive wakefulness syndrome (five males and two females, aged 45.7 ± 16.8 years) and seven cases of minimally conscious state (six males and one female, aged 42...
November 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30233061/inhibition-of-neurite-outgrowth-using-commercial-myelin-associated-glycoprotein-fc-in-neuro-2a-cells
#18
Fu Liu, Mei-Ling Gao, Juan Bai, Ya-Fang Wang, Xia-Qing Li
Myelin-associated glycoprotein (MAG) inhibits the growth of neurites from nerve cells. Extraction and purification of MAG require complex operations; therefore, we attempted to determine whether commercially available MAG-Fc can replace endogenous MAG for research purposes. Immunofluorescence using specific antibodies against MAG, Nogo receptor (NgR) and paired immunoglobulin-like receptor B (PirB) was used to determine whether MAG-Fc can be endocytosed by neuro-2a cells. In addition, neurite outgrowth of neuro-2a cells treated with different doses of MAG-Fc was evaluated...
November 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30233060/tissue-inhibitors-of-metalloproteases-strike-a-nerve
#19
Veronica I Shubayev, Alex Y Strongin
No abstract text is available yet for this article.
November 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30233059/potential-therapeutic-interventions-based-on-the-role-of-the-endoplasmic-reticulum-stress-response-in-progressive-neurodegenerative-diseases
#20
Basant K Puri, Gerwyn Morris
No abstract text is available yet for this article.
November 2018: Neural Regeneration Research
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