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Neural Regeneration Research

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https://www.readbyqxmd.com/read/30323153/-huangqin-flavonoid-extraction-for-spinal-cord-injury-in-a-rat-model
#1
Qian Zhang, Li-Xin Zhang, Jing An, Liang Yan, Cui-Cui Liu, Jing-Jing Zhao, Hao Yang
Flavonoids from Huangqin (dried roots of Scutellaria baicalensis Georgi) have anti-inflammatory effects, and are considered useful for treatment of spinal cord injury. To verify this hypothesis, the T9-10 spinal cord segments of rats were damaged using Allen's method to establish a rat spinal cord injury model. Before model establishment, Huangqin flavonoid extraction (12.5 g/kg) was administered intragastrically for 1 week until 28 days after model establishment. Methylprednisolone (30 mg/kg) was injected into the tail vein at 30 minutes after model establishment as a positive control...
December 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30323152/lithium-promotes-recovery-of-neurological-function-after-spinal-cord-injury-by-inducing-autophagy
#2
Duo Zhang, Fang Wang, Xu Zhai, Xiao-Hui Li, Xi-Jing He
Lithium promotes autophagy and has a neuroprotective effect on spinal cord injury (SCI); however, the underlying mechanisms remain unclear. Therefore, in this study, we investigated the effects of lithium and the autophagy inhibitor 3-methyladenine (3-MA) in a rat model of SCI. The rats were randomly assigned to the SCI, lithium, 3-MA and sham groups. In the 3-MA group, rats were intraperitoneally injected with 3-MA (3 mg/kg) 2 hours before SCI. In the lithium and 3-MA groups, rats were intraperitoneally injected with lithium (LiCl; 30 mg/kg) 6 hours after SCI and thereafter once daily until sacrifice...
December 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30323151/analysis-of-transcriptome-sequencing-of-sciatic-nerves-in-sprague-dawley-rats-of-different-ages
#3
Jiang-Hui Liu, Qing Tang, Xiang-Xia Liu, Jian Qi, Rui-Xi Zeng, Zhao-Wei Zhu, Bo He, Yang-Bin Xu
An aging-induced decrease in Schwann cell viability can affect regeneration following peripheral nerve injury in mammals. It is therefore necessary to investigate possible age-related changes in gene expression that may affect the biological function of peripheral nerves. Ten 1-week-old and ten 12-month-old healthy male Sprague-Dawley rats were divided into young (1 week old) and adult (12 months old) groups according to their ages. mRNA expression in the sciatic nerve was compared between young and adult rats using next-generation sequencing (NGS) and bioinformatics (n = 4/group)...
December 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30323150/exogenous-brain-derived-neurotrophic-factor-attenuates-cognitive-impairment-induced-by-okadaic-acid-in-a-rat-model-of-alzheimer-s-disease
#4
Ai-Hua Xu, Yang Yang, Yong-Xin Sun, Chao-Dong Zhang
Decreased expression of brain-derived neurotrophic factor (BDNF) plays an important role in the pathogenesis of Alzheimer's disease, and a typical pathological change in Alzheimer's disease is neurofibrillary tangles caused by hyperphosphorylation of tau. An in vivo model of Alzheimer's disease was developed by injecting okadaic acid (2 μL) and exogenous BDNF (2 μL) into the hippocampi of adult male Wister rats. Spatial learning and memory abilities were assessed using the Morris water maze. The expression levels of protein phosphatase 2A (PP2A), PP2Ac-Yp307, p-tau (Thr231), and p-tau (Ser396/404) were detected by western blot assay...
December 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30323149/partial-improvement-in-performance-of-patients-with-severe-alzheimer-s-disease-at-an-early-stage-of-fornix-deep-brain-stimulation
#5
Zhi-Qi Mao, Xin Wang, Xin Xu, Zhi-Qiang Cui, Long-Sheng Pan, Xiao-Jing Ning, Bai-Xuan Xu, Lin Ma, Zhi-Pei Ling, Jian-Jun Jia, Xin-Guang Yu
Deep brain stimulation is a therapy for Alzheimer's disease (AD) that has previously been used for mainly mild to moderate cases. This study provides the first evidence of early alterations in performance induced by stimulation targeted at the fornix in severe AD patients. The performance of the five cases enrolled in this study was scored with specialized assessments including the Mini-Mental State Examination and Clinical Dementia Rating, both before and at an early stage after deep brain stimulation. The burden of caregivers was also evaluated using the Zarit Caregiver Burden Interview...
December 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30323148/epigenetic-marks-are-modulated-by-gender-and-time-of-the-day-in-the-hippocampi-of-adolescent-rats-a-preliminary-study
#6
Viviane Rostirola Elsner, Laura Reck Cechinel, Louisiana Carolina Ferreira de Meireles, Karine Bertoldi, Ionara Rodrigues Siqueira
Although the involvement of gender in epigenetic machinery in peripheral tissues during the neonatal period has been suggested, the gender-related epigenetic profile of brain areas during the adolescent period is rarely exploited. Furthermore, the influence of time of day on hippocampal acetylation marks has been demonstrated in young adult and aged rats; however, there are no studies reporting epigenetic changes in the adolescent period. Therefore, this study aimed to investigate the effects of gender on hippocampal DNA methyltransferase 1 content and histone deacetylase (HDAC) activity of adolescent rats at different time points, specifically early morning and afternoon...
December 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30323147/corrigendum-targeting-prion-like-protein-spreading-in-neurodegenerative-diseases
#7
(no author information available yet)
[This corrects the article DOI: 10.4103/1673-5374.239433].
December 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30323146/dysphagia-in-patients-with-isolated-pontine-infarction
#8
Min Cheol Chang, Sang Gyu Kwak, Min Ho Chun
Little is known about dysphagia after pontine infarction. In this study, we evaluated the incidence of dysphagia after isolated pontine infarction and identified the predictive factors for the occurrence of dysphagia. A total of 146 patients were included in this study. All patients underwent clinical testing for dysphagia within 1 day after admission and at the time of discharge. We compared the incidence of dysphagia between patients with unilateral pontine infarction and those with bilateral pontine infarction...
December 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30323145/downregulation-of-signal-transduction-and-stat3-expression-exacerbates-oxidative-stress-mediated-by-nlrp3-inflammasome
#9
Hua Bai, Qi-Fang Zhang, Juan-Juan Duan, De-Jun Yu, Li-Jie Liu
Activated nucleotide binding to the oligonucleotide receptor protein 3 (NLRP3) inflammasome is possibly involved in the pathogenesis of Alzheimer's disease through oxidative stress and neurogenic inflammation. Low expression of the signal transducer and activator of transcription 3 (STAT3) gene may promote the occurrence of neurodegenerative diseases to some extent. To clarify the roles of the NLRP3 inflammasome and STAT3 expression in oxidative stress, (1) SHSY5Y cells were incubated with 1 mM H2 O2 to induce oxidative stress injury, and the expression of human-cell-specific signal transduction, STAT3-shRNA silencing signal transduction and STAT3 were detected...
December 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30323144/prevalence-of-white-matter-hyperintensities-increases-with-age
#10
Feng-Juan Zhuang, Yan Chen, Wen-Bo He, Zhi-You Cai
White matter hyperintensities (WMHs) that arise with age and/or atherosclerosis constitute a heterogeneous disorder in the white matter of the brain. However, the relationship between age-related risk factors and the prevalence of WMHs is still obscure. More clinical data is needed to confirm the relationship between age and the prevalence of WMHs. We collected 836 patients, who were treated in the Renmin Hospital, Hubei University of Medicine, China from January 2015 to February 2016, for a case-controlled retrospective analysis...
December 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30323143/retraction-roles-of-eph-ephrin-bidirectional-signaling-during-injury-and-recovery-of-the-central-nervous-system
#11
(no author information available yet)
[This corrects the article DOI: 10.4103/1673-5374.235217].
December 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30323142/dynamic-changes-in-growth-factor-levels-over-a-7-day-period-predict-the-functional-outcomes-of-traumatic-brain-injury
#12
Shuai Zhou, Dong-Pei Yin, Yi Wang, Ye Tian, Zeng-Guang Wang, Jian-Ning Zhang
Traumatic brain injury (TBI) can result in poor functional outcomes and death, and overall outcomes are varied. Growth factors, such as angiopoietin-1 (Ang-1), vascular endothelial growth factor (VEGF), and granulocyte-colony stimulating factor (G-CSF), play important roles in the neurological functions. This study investigated the relationship between serum growth factor levels and long-term outcomes after TBI. Blood samples from 55 patients were collected at 1, 3 and 7 days after TBI. Blood samples from 39 healthy controls were collected as a control group...
December 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30323141/neuroprotective-effect-of-baicalin-on-focal-cerebral-ischemia-in-rats
#13
Jiong Dai, Yong-Ming Qiu, Zheng-Wen Ma, Guo-Feng Yan, Jing Zhou, Shan-Quan Li, Hui Wu, Yi-Chao Jin, Xiao-Hua Zhang
Baicalin, a flavonoid compound from the root of the herb Scutellaria baicalensis Georgi, has been widely used to treat patients with inflammatory disease. The aim of this study was to assess the efficacy of baicalin in a rat model of focal cerebral ischemia. Adult male Sprague-Dawley rat models of cerebral artery occlusion were established and then randomly and equally divided into three groups: ischemia (cerebral ischemia and reperfusion), valproic acid (cerebral ischemia and reperfusion + three intraperitoneal injections of valproic acid; positive control), and baicalin (cerebral ischemia and reperfusion + intraperitoneal injection of baicalin for 21 days)...
December 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30323140/rosmarinic-acid-elicits-neuroprotection-in-ischemic-stroke-via-nrf2-and-heme-oxygenase-1-signaling
#14
Hai-Ying Cui, Xiang-Jian Zhang, Yi Yang, Cong Zhang, Chun-Hua Zhu, Jiang-Yong Miao, Rong Chen
Rosmarinic acid (RA) can elicit a neuroprotective effect against ischemic stroke, but the precise molecular mechanism remains poorly understood. In this study, an experimental ischemic stroke model was established in CD-1 mice (Beijing Vital River Laboratory Animal Technology, Beijing, China) by occluding the right middle cerebral artery for 1 hour and allowing reperfusion for 24 hours. After intraperitoneally injecting model mice with 10, 20, or 40 mg/kg RA, functional neurological deficits were evaluated using modified Longa scores...
December 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30323139/2-2-benzofuranyl-2-imidazoline-treatment-within-5-hours-after-cerebral-ischemia-reperfusion-protects-the-brain
#15
Zheng Zhang, Jin-Long Yang, Lin-Lei Zhang, Zhen-Zhen Chen, Jia-Ou Chen, Yun-Gang Cao, Man Qu, Xin-Da Lin, Xun-Ming Ji, Zhao Han
We previously demonstrated that administering 2-(2-benzofuranyl)-2-imidazolin (2-BFI), an imidazoline I2 receptor agonist, immediately after ischemia onset can protect the brain from ischemic insult. However, immediate administration after stroke is difficult to realize in the clinic. Thus, the therapeutic time window of 2-BFI should be determined. Sprague-Dawley rats provided by Wenzhou Medical University in China received right middle cerebral artery occlusion for 120 minutes, and were treated with 2-BFI (3 mg/kg) through the caudal vein at 0, 1, 3, 5, 7, and 9 hours after reperfusion...
December 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30323138/peptide-aptamer-mediated-modulation-of-prion-protein-%C3%AE-cleavage-as-treatment-strategy-for-prion-and-other-neurodegenerative-diseases
#16
Antonia N Klein, Erica Corda, Sabine Gilch
No abstract text is available yet for this article.
December 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30323137/cell-based-therapy-in-alzheimer-s-disease-can-human-fetal-cholinergic-neurons-untangle-the-skein
#17
Giulia Guarnieri, Erica Sarchielli, Gabriella B Vannelli, Annamaria Morelli
No abstract text is available yet for this article.
December 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30323136/nose-to-brain-drug-delivery-approach-a-key-to-easily-accessing-the-brain-for-the-treatment-of-alzheimer-s-disease
#18
Amit Alexander, Shailendra Saraf
No abstract text is available yet for this article.
December 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30323135/putative-roles-of-cathepsin-b-in-alzheimer-s-disease-pathology-the-good-the-bad-and-the-ugly-in-one
#19
Hans-Gert Bernstein, Gerburg Keilhoff
No abstract text is available yet for this article.
December 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30323134/consequences-of-redefining-alzheimer-s-disease-in-terms-of-amyloid-burden-without-regard-to-cognitive-decline
#20
Stephen R Robinson, Holly M Brothers, Maya L Gosztyla
No abstract text is available yet for this article.
December 2018: Neural Regeneration Research
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