journal
MENU ▼
Read by QxMD icon Read
search

Neural Regeneration Research

journal
https://www.readbyqxmd.com/read/28469668/anesthetic-considerations-for-patients-with-acute-cervical-spinal-cord-injury
#1
REVIEW
Fang-Ping Bao, Hong-Gang Zhang, Sheng-Mei Zhu
Anesthesiologists work to prevent or minimize secondary injury of the nervous system and improve the outcome of medical procedures. To this end, anesthesiologists must have a thorough understanding of pathophysiology and optimize their skills and equipment to make an anesthesia plan. Anesthesiologists should conduct careful physical examinations of patients and consider neuroprotection at preoperative interviews, consider cervical spinal cord movement and compression during airway management, and suggest awake fiberoptic bronchoscope intubation for stable patients and direct laryngoscopy with manual in-line immobilization in emergency situations...
March 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28469667/transplantation-of-autologous-peripheral-blood-mononuclear-cells-in-the-subarachnoid-space-for-amyotrophic-lateral-sclerosis-a-safety-analysis-of-14-patients
#2
Xiao-Yan Li, Zhan-Hua Liang, Chao Han, Wen-Juan Wei, Chun-Li Song, Li-Na Zhou, Yang Liu, Ying Li, Xiao-Fei Ji, Jing Liu
There is a small amount of clinical data regarding the safety and feasibility of autologous peripheral blood mononuclear cell transplantation into the subarachnoid space for the treatment of amyotrophic lateral sclerosis. The objectives of this retrospective study were to assess the safety and efficacy of peripheral blood mononuclear cell transplantation in 14 amyotrophic lateral sclerosis patients to provide more objective data for future clinical trials. After stem cell mobilization and collection, autologous peripheral blood mononuclear cells (1 × 10(9)) were isolated and directly transplanted into the subarachnoid space of amyotrophic lateral sclerosis patients...
March 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28469666/anatomical-distributional-defects-in-mutant-genes-associated-with-dominant-intermediate-charcot-marie-tooth-disease-type-c-in-an-adenovirus-mediated-mouse-model
#3
SeoJin Lee, Sandesh Panthi, Hyun Woo Jo, Jaeyoung Cho, Min-Sik Kim, Na Young Jeong, In Ok Song, Junyang Jung, Youngbuhm Huh
Dominant intermediate Charcot-Marie-Tooth disease type C (DI-CMTC) is a dominantly inherited neuropathy that has been classified primarily based on motor conduction velocity tests but is now known to involve axonal and demyelination features. DI-CMTC is linked to tyrosyl-tRNA synthetase (YARS)-associated neuropathies, which are caused by E196K and G41R missense mutations and a single de novo deletion (153-156delVKQV). It is well-established that these YARS mutations induce neuronal dysfunction, morphological symptoms involving axonal degeneration, and impaired motor performance...
March 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28469665/mechanisms-responsible-for-the-inhibitory-effects-of-epothilone-b-on-scar-formation-after-spinal-cord-injury
#4
Wei Zhao, Yong Chai, Yun Hou, Da-Wei Wang, Jian-Qiang Xing, Cheng Yang, Qing-Min Fang
Scar formation after spinal cord injury is regarded as an obstacle to axonal regeneration and functional recovery. Epothilone B provides moderate microtubule stabilization and is mainly used for anti-tumor therapy. It also reduces scar tissue formation and promotes axonal regeneration after spinal cord injury. The aim of the present study was to investigate the effect and mechanism of the microtubule-stabilizing reagent epothilone B in decreasing fibrotic scarring through its action on pericytes after spinal cord injury...
March 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28469664/the-mechanism-of-naringin-enhanced-remyelination-after-spinal-cord-injury
#5
Wei Rong, Yong-Wei Pan, Xu Cai, Fei Song, Zhe Zhao, Song-Hua Xiao, Cheng Zhang
Our previous study revealed that intragastric administration of naringin improved remyelination in rats with spinal cord injury and promoted the recovery of neurological function of the injured spinal cord. This study sought to reveal the mechanisms by which naringin improves oligodendrocyte precursor cell differentiation and maturation, and promotes remyelination. Spinal cord injury was induced in rats by the weight-drop method. Naringin was intragastrically administered daily (20, 40 mg/kg) for 4 weeks after spinal cord injury induction...
March 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28469663/estrogen-affects-neuropathic-pain-through-upregulating-n-methyl-d-aspartate-acid-receptor-1-expression-in-the-dorsal-root-ganglion-of-rats
#6
Chao Deng, Ya-Juan Gu, Hong Zhang, Jun Zhang
Estrogen affects the generation and transmission of neuropathic pain, but the specific regulatory mechanism is still unclear. Activation of the N-methyl-D-aspartate acid receptor 1 (NMDAR1) plays an important role in the production and maintenance of hyperalgesia and allodynia. The present study was conducted to determine whether a relationship exists between estrogen and NMDAR1 in peripheral nerve pain. A chronic sciatic nerve constriction injury model of chronic neuropathic pain was established in rats. These rats were then subcutaneously injected with 17β-estradiol, the NMDAR1 antagonist D(-)-2-amino-5-phosphonopentanoic acid (AP-5), or both once daily for 15 days...
March 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28469662/combination-therapy-using-evening-primrose-oil-and-electrical-stimulation-to-improve-nerve-function-following-a-crush-injury-of-sciatic-nerve-in-male-rats
#7
Omid Badri, Parviz Shahabi, Jalal Abdolalizadeh, Mohammad Reza Alipour, Hadi Veladi, Mehdi Farhoudi, Mohsen Sharif Zak
Peripheral nerve injuries with a poor prognosis are common. Evening primrose oil (EPO) has beneficial biological effects and immunomodulatory properties. Since electrical activity plays a major role in neural regeneration, the present study investigated the effects of electrical stimulation (ES), combined with evening primrose oil (EPO), on sciatic nerve function after a crush injury in rats. In anesthetized rats, the sciatic nerve was crushed using small haemostatic forceps followed by ES and/or EPO treatment for 4 weeks...
March 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28469661/guinea-pigs-as-an-animal-model-for-sciatic-nerve-injury
#8
Malik Abu Rafee, Amarpal, Prakash Kinjavdekar, Hari Prasad Aithal, Sajad Ahmad Wani, Irfan Ahmad Bhat
The overwhelming use of rat models in nerve regeneration studies is likely to induce skewness in treatment outcomes. To address the problem, this study was conducted in 8 adult guinea pigs of either sex to investigate the suitability of guinea pig as an alternative model for nerve regeneration studies. A crush injury was inflicted to the sciatic nerve of the left limb, which led to significant decrease in the pain perception and neurorecovery up to the 4(th) weak. Lengthening of foot print and shortening of toe spread were observed in the paw after nerve injury...
March 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28469660/modulation-of-neuronal-dynamic-range-using-two-different-adaptation-mechanisms
#9
Lei Wang, Ye Wang, Wen-Long Fu, Li-Hong Cao
The capability of neurons to discriminate between intensity of external stimulus is measured by its dynamic range. A larger dynamic range indicates a greater probability of neuronal survival. In this study, the potential roles of adaptation mechanisms (ion currents) in modulating neuronal dynamic range were numerically investigated. Based on the adaptive exponential integrate-and-fire model, which includes two different adaptation mechanisms, i.e. subthreshold and suprathreshold (spike-triggered) adaptation, our results reveal that the two adaptation mechanisms exhibit rather different roles in regulating neuronal dynamic range...
March 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28469659/stress-injuries-and-autophagy-in-mouse-hippocampus-after-chronic-cold-exposure
#10
Ting-Ting Qu, Jie-Xin Deng, Rui-Ling Li, Zhan-Jun Cui, Xiao-Qing Wang, Lai Wang, Jin-Bo Deng
Cold exposure is an external stress factor that causes skin frostbite as well as a variety of diseases. Estrogen might participate in neuroprotection after cold exposure, but its precise mechanism remains unclear. In this study, mice were exposed to 10°C for 7 days and 0-4°C for 30 days to induce a model of chronic cold exposure. Results showed that oxidative stress-related c-fos and cyclooxygenase 2 expressions, MAP1LC3-labeled autophagic cells, Iba1-labeled activated microglia, and interleukin-1β-positive pyramidal cells were increased in the hippocampal CA1 area...
March 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28469658/neural-stem-cells-over-expressing-brain-derived-neurotrophic-factor-promote-neuronal-survival-and-cytoskeletal-protein-expression-in-traumatic-brain-injury-sites
#11
Tao Chen, Yan Yu, Liu-Jiu Tang, Li Kong, Cheng-Hong Zhang, Hai-Ying Chu, Liang-Wei Yin, Hai-Ying Ma
Cytoskeletal proteins are involved in neuronal survival. Brain-derived neurotrophic factor can increase expression of cytoskeletal proteins during regeneration after axonal injury. However, the effect of neural stem cells genetically modified by brain-derived neurotrophic factor transplantation on neuronal survival in the injury site still remains unclear. To examine this, we established a rat model of traumatic brain injury by controlled cortical impact. At 72 hours after injury, 2 × 10(7) cells/mL neural stem cells overexpressing brain-derived neurotrophic factor or naive neural stem cells (3 mL) were injected into the injured cortex...
March 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28469657/fermented-chinese-formula-shuan-tong-ling-attenuates-ischemic-stroke-by-inhibiting-inflammation-and-apoptosis
#12
Zhi-Gang Mei, Ling-Jing Tan, Jin-Feng Wang, Xiao-Li Li, Wei-Feng Huang, Hua-Jun Zhou
The fermented Chinese formula Shuan-Tong-Ling is composed of radix puerariae (Gegen), salvia miltiorrhiza (Danshen), radix curcuma (Jianghuang), hawthorn (Shanzha), salvia chinensis (Shijianchuan), sinapis alba (Baijiezi), astragalus (Huangqi), panax japonicas (Zhujieshen), atractylodes macrocephala koidz (Baizhu), radix paeoniae alba (Baishao), bupleurum (Chaihu), chrysanthemum (Juhua), rhizoma cyperi (Xiangfu) and gastrodin (Tianma), whose aqueous extract was fermented with lactobacillus, bacillus aceticus and saccharomycetes...
March 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28469656/neuroprotective-effects-of-autophagy-inhibition-on-hippocampal-glutamate-receptor-subunits-after-hypoxia-ischemia-induced-brain-damage-in-newborn-rats
#13
Li-Xiao Xu, Xiao-Juan Tang, Yuan-Yuan Yang, Mei Li, Mei-Fang Jin, Po Miao, Xin Ding, Ying Wang, Yan-Hong Li, Bin Sun, Xing Feng
Autophagy has been suggested to participate in the pathology of hypoxic-ischemic brain damage (HIBD). However, its regulatory role in HIBD remains unclear and was thus examined here using a rat model. To induce HIBD, the left common carotid artery was ligated in neonatal rats, and the rats were subjected to hypoxia for 2 hours. Some of these rats were intraperitoneally pretreated with the autophagy inhibitor 3-methyladenine (10 mM in 10 μL) or the autophagy stimulator rapamycin (1 g/kg) 1 hour before artery ligation...
March 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28469655/electroacupuncture-reduces-apoptotic-index-and-inhibits-p38-mitogen-activated-protein-kinase-signaling-pathway-in-the-hippocampus-of-rats-with-cerebral-ischemia-reperfusion-injury
#14
Xiao Lan, Xin Zhang, Guo-Ping Zhou, Chun-Xiao Wu, Chun Li, Xiu-Hong Xu
Electroacupuncture attenuates cerebral hypoxia and neuronal apoptosis induced by cerebral ischemia/reperfusion injury. To further identify the involved mechanisms, we assumed that electroacupuncture used to treat cerebral ischemia/reperfusion injury was associated with the p38 mitogen-activated protein kinase (MAPK) signaling pathway. We established rat models of cerebral ischemia/reperfusion injury using the modified Zea-Longa's method. At 30 minutes before model establishment, p38 MAPK blocker SB20358 was injected into the left lateral ventricles...
March 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28469654/amyotrophic-lateral-sclerosis-disease-modifying-therapeutics-a-cell-biological-perspective
#15
Bor Luen Tang
No abstract text is available yet for this article.
March 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28469653/new-approaches-for-prevention-and-treatment-of-alzheimer-s-disease-a-fascinating-challenge
#16
Luca Piemontese
No abstract text is available yet for this article.
March 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28469652/neurorestoration-from-medicinal-plants-an-opportunity-to-treat-painful-neuropathies
#17
Lorenzo Di Cesare Mannelli, Carla Ghelardini
No abstract text is available yet for this article.
March 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28469651/elevated-nkcc1-transporter-expression-facilitates-early-post-traumatic-brain-injury-seizures
#18
Buqing Liang, Jason H Huang
No abstract text is available yet for this article.
March 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28469650/targeting-colony-stimulating-factor-1-receptor-to-prevent-cognitive-deficits-induced-by-fractionated-whole-brain-irradiation
#19
Xi Feng, Susanna Rosi
No abstract text is available yet for this article.
March 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28469649/small-regulators-making-big-impacts-regulation-of-neural-stem-cells-by-small-non-coding-rnas
#20
Zhong Liu, Rui Zhao
No abstract text is available yet for this article.
March 2017: Neural Regeneration Research
journal
journal
41745
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"