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Neural Regeneration Research

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https://www.readbyqxmd.com/read/29722330/use-of-curcumin-in-diagnosis-prevention-and-treatment-of-alzheimer-s-disease
#1
REVIEW
Min Chen, Zhi-Yun Du, Xi Zheng, Dong-Li Li, Ren-Ping Zhou, Kun Zhang
This review summarizes and describes the use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease. For diagnosis of Alzheimer's disease, amyloid-β and highly phosphorylated tau protein are the major biomarkers. Curcumin was developed as an early diagnostic probe based on its natural fluorescence and high binding affinity to amyloid-β. Because of its multi-target effects, curcumin has protective and preventive effects on many chronic diseases such as cerebrovascular disease, hypertension, and hyperlipidemia...
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29722329/alpha-7-nicotinic-acetylcholine-receptor-agonist-treatment-in-a-rat-model-of-huntington-s-disease-and-involvement-of-heme-oxygenase-1
#2
Laura Foucault-Fruchard, Claire Tronel, Sylvie Bodard, Zuhal Gulhan, Julie Busson, Sylvie Chalon, Daniel Antier
Neuroinflammation is a common element involved in the pathophysiology of neurodegenerative diseases. We recently reported that repeated alpha-7 nicotinic acetylcholine receptor (α7nAChR) activations by a potent agonist such as PHA 543613 in quinolinic acid-injured rats exhibited protective effects on neurons. To further investigate the underlying mechanism, we established rat models of early-stage Huntington's disease by injection of quinolinic acid into the right striatum and then intraperitoneally injected 12 mg/kg PHA 543613 or sterile water, twice a day during 4 days...
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29722328/compound-of-icariin-astragalus-and-puerarin-mitigates-iron-overload-in-the-cerebral-cortex-of-alzheimer-s-disease-mice
#3
Yu Zhang, Wei-Na Kong, Xi-Qing Chai
Increasing evidence indicates that disruption of normal iron homeostasis may contribute to pathological development of Alzheimer's disease. Icariin, astragalus, and puerarin have been shown to suppress iron overload in the cerebral cortex and improve spatial learning and memory disorders in Alzheimer's disease mice, although the underlying mechanism remains unclear. In the present study, APPswe/PS1ΔE9 transgenic mice were administered icariin, astragalus, and puerarin (120, 80, and 80 mg/kg, respectively, once a day, for 3 months)...
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29722327/structural-neural-connectivity-of-the-vestibular-nuclei-in-the-human-brain-a-diffusion-tensor-imagings-study
#4
Sung Ho Jang, Mi Young Lee, Sang Seok Yeo, Hyeok Gyu Kwon
Many animal studies have reported on the neural connectivity of the vestibular nuclei (VN). However, little is reported on the structural neural connectivity of the VN in the human brain. In this study, we attempted to investigate the structural neural connectivity of the VN in 37 healthy subjects using diffusion tensor tractography. A seed region of interest was placed on the isolated VN using probabilistic diffusion tensor tractography. Connectivity was defined as the incidence of connection between the VN and each brain region...
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29722326/intracerebroventricularly-administered-1-methyl-4-phenylpyridinium-ion-and-brain-derived-neurotrophic-factor-affect-catecholaminergic-nerve-terminals-and-neurogenesis-in-the-hippocampus-striatum-and-substantia-nigra
#5
Jun-Fang Chen, Man Wang, Ying-Han Zhuang, Thomas Behnisch
Parkinson's disease is a progressive neurological disease characterized by the degeneration of dopaminergic neurons in the substantia nigra. A highly similar pattern of neurodegeneration can be induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or 1-methyl-4-phenylpyridinium ion (MPP+ ), which cause the death of dopaminergic neurons. Administration of MPTP or MPP+ results in Parkinson's disease-like symptoms in rodents. However, it remains unclear whether intracerebroventricular MPP+ administration affects neurogenesis in the substantia nigra and subgranular zone or whether brain-derived neurotrophic factor alters the effects of MPP+ ...
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29722325/induced-dural-lymphangiogenesis-facilities-soluble-amyloid-beta-clearance-from-brain-in-a-transgenic-mouse-model-of-alzheimer-s-disease
#6
Ya-Ru Wen, Jun-Hua Yang, Xiao Wang, Zhi-Bin Yao
Impaired amyloid-β clearance from the brain is a core pathological event in Alzheimer's disease. The therapeutic effect of current pharmacotherapies is unsatisfactory, and some treatments cause severe side effects. The meningeal lymphatic vessels might be a new route for amyloid-β clearance. This study investigated whether promoting dural lymphangiogenesis facilitated the clearance of amyloid-β from the brain. First, human lymphatic endothelial cells were treated with 100 ng/mL recombinant human vascular endothelial growth factor-C (rhVEGF-C) protein...
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29722324/brain-remodeling-after-chronic-median-nerve-compression-in-a-rat-model
#7
Bing-Bo Bao, Dan-Qian Qu, Hong-Yi Zhu, Tao Gao, Xian-You Zheng
Carpal tunnel syndrome is the most common compressive neuropathy, presenting with sensorimotor dysfunction. In carpal tunnel syndrome patients, irregular afferent signals on functional magnetic resonance imaging are associated with changes in neural plasticity during peripheral nerve injury. However, it is difficult to obtain multi-point neuroimaging data of the brain in the clinic. In the present study, a rat model of median nerve compression was established by median nerve ligation, i.e., carpal tunnel syndrome model...
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29722323/end-to-end-and-end-to-side-neurorrhaphy-between-thick-donor-nerves-and-thin-recipient-nerves-an-axon-regeneration-study-in-a-rat-model
#8
Tohru Tateshita, Kazuki Ueda, Akiyoshi Kajikawa
During nerve reconstruction, nerves of different thicknesses are often sutured together using end-to-side neurorrhaphy and end-to-end neurorrhaphy techniques. In this study, the effect of the type of neurorrhaphy on the number and diameter of regenerated axon fibers was studied in a rat facial nerve repair model. An inflow-type end-to-side and end-to-end neurorrhaphy model with nerve stumps of different thicknesses (2:1 diameter ratio) was created in the facial nerve of 14 adult male Sprague-Dawley rats. After 6 and 12 weeks, nerve regeneration was evaluated in the rats using the following outcomes: total number of myelinated axons, average minor axis diameter of the myelinated axons in the central and peripheral sections, and axon regeneration rate...
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29722322/treatment-with-acetyl-l-carnitine-exerts-a-neuroprotective-effect-in-the-sciatic-nerve-following-loose-ligation-a-functional-and-microanatomical-study
#9
Daniele Tomassoni, Lorenzo Di Cesare Mannelli, Vincenzo Bramanti, Carla Ghelardini, Francesco Amenta, Alessandra Pacini
Peripheral neuropathies are chronic painful syndromes characterized by allodynia, hyperalgesia and altered nerve functionality. Nerve tissue degeneration represents the microanatomical correlate of peripheral neuropathies. Aimed to improve the therapeutic possibilities, this study investigated the hypersensitivity and the neuromorphological alterations related to the loose ligation of the sciatic nerve in rats. Effects elicited by treatment with acetyl-L-carnitine (ALCAR) in comparison to gabapentin were assessed...
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29722321/macrophage-depletion-and-schwann-cell-transplantation-reduce-cyst-size-after-rat-contusive-spinal-cord-injury
#10
Yee-Shuan Lee, Lucy H Funk, Jae K Lee, Mary Bartlett Bunge
Schwann cell transplantation is a promising therapy for the treatment of spinal cord injury (SCI) and is currently in clinical trials. In our continuing efforts to improve Schwann cell transplantation strategies, we sought to determine the combined effects of Schwann cell transplantation with macrophage depletion. Since macrophages are major inflammatory contributors to the acute spinal cord injury, and are the major phagocytic cells, we hypothesized that transplanting Schwann cells after macrophage depletion will improve cell survival and integration with host tissue after SCI...
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29722320/the-rho-associated-kinase-inhibitors-y27632-and-fasudil-promote-microglial-migration-in-the-spinal-cord-via-the-erk-signaling-pathway
#11
Pei-Cai Fu, Rong-Hua Tang, Zhi-Yuan Yu, Min-Jie Xie, Wei Wang, Xiang Luo
Rho-associated kinase (ROCK) is a key regulatory protein involved in inflammatory secretion in microglia in the central nervous system. Our previous studies showed that ROCK inhibition enhances phagocytic activity in microglia through the extracellular signal-regulated kinase (ERK) signaling pathway, but its effect on microglial migration was unknown. Therefore, in this study, we investigated the effects of the ROCK inhibitors Y27632 and fasudil on the migratory activity of primary cultured microglia isolated from the spinal cord, and we examined the underlying mechanisms...
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29722319/dry-needling-at-myofascial-trigger-points-mitigates-chronic-post-stroke-shoulder-spasticity
#12
Li Tang, Yan Li, Qiang-Min Huang, Yang Yang
Post-stroke spasticity is associated with restriction in the range of motion of the shoulder. Reducing muscular dystrophy may help relieve muscular dysfunction in patients with post-stroke shoulder spasticity. Dry needle therapy is a method of needling the trigger points using a syringe needle without the use of a drug. Dry needle therapy is commonly used for pain at the shoulder, neck, waist, and back. In this case study, a 62-year-old male patient affected with cerebral hemorrhage of the right frontal lobe had received rehabilitative treatment for 12 years...
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29722318/-panax-ginseng-extract-attenuates-neuronal-injury-and-cognitive-deficits-in-rats-with-vascular-dementia-induced-by-chronic-cerebral-hypoperfusion
#13
Jun-De Zhu, Jun-Jie Wang, Xian-Hu Zhang, Yan Yu, Zhao-Sheng Kang
Panax ginseng is a slow-growing perennial plant. Panax ginseng extract has numerous biological activities, including antitumor, anti-inflammatory and antistress activities. Panax ginseng extract also has a cognition-enhancing effect in rats with alcohol-induced memory impairment. In this study, we partially occluded the bilateral carotid arteries in the rat to induce chronic cerebral hypoperfusion, a well-known model of vascular dementia. The rats were then intragastrically administered 50 or 100 mg/kg Panax ginseng extract...
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29722317/exendin-4-inhibits-high-altitude-cerebral-edema-by-protecting-against-neurobiological-dysfunction
#14
Zhong-Lei Sun, Xian-Feng Jiang, Yuan-Chi Cheng, Ying-Fu Liu, Kai Yang, Shuang-Long Zhu, Xian-Bin Kong, Yue Tu, Ke-Feng Bian, Zhen-Lin Liu, Xu-Yi Chen
The anti-inflammatory and antioxidant effects of exendin-4 (Ex-4) have been reported previously. However, whether (Ex-4) has anti-inflammatory and antioxidant effects on high-altitude cerebral edema (HACE) remains poorly understood. In this study, two rat models of HACE were established by placing rats in a hypoxic environment with a simulated altitude of either 6000- or 7000-m above sea level (MASL) for 72 hours. An altitude of 7000 MASL with 72-hours of hypoxia was found to be the optimized experimental paradigm for establishing HACE models...
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29722316/astrocytic-kir4-1-potassium-channels-as-a-novel-therapeutic-target-for-epilepsy-and-mood-disorders
#15
Yukihiro Ohno
No abstract text is available yet for this article.
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29722315/dopaminergic-mediation-in-the-brain-aging-and-neurodegenerative-diseases-a-role-of-senescent-cells
#16
Pavel V Nekrasov, Vasily V Vorobyov
No abstract text is available yet for this article.
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29722314/impacts-of-increased-%C3%AE-synuclein-on-clathrin-mediated-endocytosis-at-synapses-implications-for-neurodegenerative-diseases
#17
Audrey T Medeiros, Luigi Bubacco, Jennifer R Morgan
No abstract text is available yet for this article.
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29722313/ketamine-enhances-structural-plasticity-in-human-dopaminergic-neurons-possible-relevance-for-treatment-resistant-depression
#18
Ginetta Collo, Emilio Merlo Pich
No abstract text is available yet for this article.
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29722312/neuromodulator-interactions-and-spinal-cord-injury-in-lamprey
#19
David Parker, Thomas J McClelland
No abstract text is available yet for this article.
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29722311/targeted-tissue-engineering-hydrogels-with-linear-capillary-channels-for-axonal-regeneration-after-spinal-cord-injury
#20
Shengwen Liu, Armin Blesch
No abstract text is available yet for this article.
April 2018: Neural Regeneration Research
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