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Therapeutic Advances in Cardiovascular Disease

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https://www.readbyqxmd.com/read/27884949/control-of-blood-pressure-and-cardiovascular-risk-in-moroccan-patients-with-newly-diagnosed-hypertension-a-3-month-observational-study-in-primary-care
#1
Mohamed Alami, Mustapha El Hattaoui, Mehdi Seqat, Jamaa Sadik, Aicha Aouad, Mohammed Benghanem Gharbi
BACKGROUND: Control of blood pressure and reduction of cardiovascular risk factors are mandatory in patients with hypertension. The aim of this study was to determine the proportion of patients with controlled hypertension and to describe the cardiovascular risk profile in hypertensive patients followed by general practitioners (GPs) in Morocco. METHODS: This national, observational, multicentre, prospective, longitudinal study of patients with newly diagnosed hypertension was carried out between September 2011 and December 2011...
November 24, 2016: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/27784812/the-protective-role-of-vitamin-d-on-the-heart-and-the-kidney
#2
REVIEW
Walter Manucha, Luis I Juncos
For a long time, vitamin D was regarded as an essential component for the maintenance of appropriate calcium metabolism. Indeed, the calcium-related functions were broadly studied and validated in numerous clinical and epidemiologic studies. All of these vitamin D effects are mediated by a specific receptor. Remarkably, recent investigations show that the vitamin D receptor (VDR) also affects autoimmunity and by these means, the course of neoplasias and tissue inflammation. Moreover, the VDR regulates genes that affect cellular activity including cell differentiation and apoptosis and, by these means, angiogenesis...
October 26, 2016: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/27765885/novel-oral-anticoagulants-for-acute-coronary-syndrome
#3
April Robinson, Delilah McCarty, Janine Douglas
Acute coronary syndrome (ACS) is a cardiovascular condition with a multifactorial pathophysiology that includes atherosclerotic plaques, platelet activation and thrombin production, among others. Thrombin production and the prothrombotic state of ACS patients have provided a role for anticoagulants to treat patients during the acute event and has led to subsequent research for the post-acute state. Warfarin has an indication for ACS, however, it is restricted to specific patients and many factors limit its use...
October 7, 2016: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/27659287/emerging-role-of-ivabradine-for-rate-control-in-atrial-fibrillation
#4
REVIEW
Sarah L Turley, Kerry E Francis, Denise K Lowe, William D Cahoon
Control of ventricular rate is recommended for patients with paroxysmal, persistent, or permanent atrial fibrillation (AF). Existing rate-control options, including beta-blockers, nondihydropyridine calcium channel blockers, and digoxin, are limited by adverse hemodynamic effects and their ability to attain target heart rate (HR). Ivabradine, a novel HR-controlling agent, decreases HR through deceleration of conduction through If ('funny') channels, and is approved for HR reduction in heart failure patients with ejection fraction less than 35% and elevated HR, despite optimal pharmacological treatment...
December 2016: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/27378486/surrogate-and-clinical-endpoints-in-interventional-cardiology-are-statistics-the-brakes
#5
REVIEW
Matthias Waliszewski, Harald Rittger
BACKGROUND: Randomized controlled trials are the gold standard for demonstrating safety and efficacy of coronary devices with or without accompanying drug treatments in interventional cardiology. With the advent of last-generation drug-eluting stents having enhanced technical attributes and long-term clinical benefits, the proof of incremental angiographic or long-term clinical efficacy becomes more challenging. The purpose of this review is to provide an overview of the most common and alternative study endpoints in interventional cardiology and their potential reimbursement value...
October 2016: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/27122492/aldosterone-is-associated-with-left-ventricular-hypertrophy-in-hemodialysis-patients
#6
REVIEW
Greicy Mara Mengue Feniman De Stefano, Silméia Garcia Zanati-Basan, Laercio Martins De Stefano, Viviana Rugolo Oliveira E Silva, Patrícia Santi Xavier, Pasqual Barretti, Roberto Jorge da Silva Franco, Jacqueline Costa Teixeira Caramori, Luis Cuadrado Martin
OBJECTIVES: Patients with chronic kidney disease present a higher degree of left ventricular hypertrophy than expected for hypertension levels. In chronic kidney disease the plot between the quotient extracellular water/total body water and aldosterone is shifted up and to the right. There are few studies that verified the role of aldosterone in cardiac remodeling in this set of patients. The aim of this study was to evaluate the relationship between serum aldosterone and left ventricular mass index in patients with chronic kidney disease on hemodialysis...
October 2016: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/27090286/management-of-rivaroxaban-in-relation-to-bodyweight-and-body-mass-index
#7
REVIEW
James Uprichard
Being overweight or obese is associated with a higher individual risk of venous thromboembolism and poorer postprocedural outcomes after hip or knee replacement surgery. In addition, there is evidence that obesity represents a significant driving factor for the current and projected prevalence of atrial fibrillation. Rivaroxaban and other direct oral anticoagulants offer fixed-dose regimens for these indications. They do not require therapeutic drug monitoring or dose adjustment according to the weight of the patient...
October 2016: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/26755746/the-emerging-role-of-endothelin-1-in-the-pathogenesis-of-pre-eclampsia
#8
REVIEW
Langeza Saleh, Koen Verdonk, Willy Visser, Anton H van den Meiracker, A H Jan Danser
Pre-eclampsia (PE) is the most frequently encountered medical complication during pregnancy. It is characterized by a rise in systemic vascular resistance with a relatively low cardiac output and hypovolemia, combined with severe proteinuria. Despite the hypovolemia, renin-angiotensin system (RAS) activity is suppressed and aldosterone levels are decreased to the same degree as renin. This suggests that the RAS is not the cause of the hypertension in PE, but rather that its suppression is the consequence of the rise in blood pressure...
October 2016: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/27587602/diuretics-prevent-rho-kinase-activation-and-expression-of-profibrotic-oxidative-genes-in-the-hypertensive-aortic-wall
#9
Patricio Araos, David Mondaca, Jorge E Jalil, Cristián Yañez, Ulises Novoa, Italo Mora, María Paz Ocaranza
BACKGROUND: Diuretics are current antihypertensive drugs since they reduce blood pressure and cardiovascular risk. Increased vascular tone is modulated in a relevant way by the RhoA/Rho-kinase (ROCK) pathway, by acting on vascular smooth muscle cell contraction. This pathway has also proremodeling vascular effects. There are few data on the role of diuretics on both vascular ROCK activation and on proremodeling effects. We assessed the effects of hydrochlorothiazide (HCTZ) and spironolactone (spiro) alone and in combination with the ROCK inhibitor fasudil (FAS) on ROCK activation, gene expression of proremodeling markers and on hypertrophy in the aortic wall of hypertensive rats...
September 1, 2016: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/27555569/primary-and-key-secondary-results-from-the-rocket-af-trial-and-their-implications-on-clinical-practice
#10
Rohan Shah, Manesh R Patel
BACKGROUND: The safety and efficacy of the oral anticoagulant rivaroxaban were studied in the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF trial). A number of subanalyses of the ROCKET AF trial have subsequently analyzed the use of rivaroxaban in special patient populations. METHODS: The outcomes of the ROCKET AF trial were reviewed. The use of rivaroxaban in higher risk populations, as determined by the presence of co-morbidities included in the CHADS2 criteria, was analyzed...
August 23, 2016: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/27215618/nitric-oxide-in-paediatric-respiratory-disorders-novel-interventions-to-address-associated-vascular-phenomena
#11
REVIEW
Farhana Akter, Gerry Coghlan, Achala de Mel
Nitric oxide (NO) has a significant role in modulating the respiratory system and is being exploited therapeutically. Neonatal respiratory failure can affect around 2% of all live births and is responsible for over one third of all neonatal mortality. Current treatment method with inhaled NO (iNO) has demonstrated great benefits to patients with persistent pulmonary hypertension, bronchopulmonary dysplasia and neonatal respiratory distress syndrome. However, it is not without its drawbacks, which include the need for patients to be attached to mechanical ventilators...
August 2016: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/27099243/new-onset-lone-atrial-fibrillation-in-pregnancy
#12
LETTER
Viswajit Reddy Anugu, Nikhil Nalluri, Deepak Asti, Sainath Gaddam, Thomas Vazzana, James Lafferty
No abstract text is available yet for this article.
August 2016: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/27099242/efficacy-of-topical-local-anaesthesia-to-reduce-perioperative-pain-for-endovenous-laser-ablation-of-varicose-veins-a-double-blind-randomized-controlled-trial
#13
Sunita Saha, Alok Tiwari, Charlotte Hunns, Jonathan Refson, Ahmed Abidia
OBJECTIVES: Tumescent local anaesthesia via multiple injections in the perivenous space leads to intraoperative and postoperative pain during endovenous laser ablation (EVLA). We considered whether the application of topical local anaesthesia reduces pain caused by these injections. METHODS: Eligible patients undergoing local anaesthetic EVLA were recruited and randomized to either application of topical local anaesthesia or water-based gel (placebo) to the inner thigh over the marked great saphenous vein...
August 2016: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/27060185/validated-formulae-for-estimation-of-whole-blood-viscosity-underestimate-the-influence-of-erythrocyte-aggregation-and-deformability
#14
LETTER
Joseph Weidman, Gregory Sloop, John A St Cyr
No abstract text is available yet for this article.
August 2016: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/26920372/multiple-medication-polypharmacy-and-chronic-kidney-disease-in-patients-aged-60-and-older-a-pharmacoepidemiologic-perspective
#15
Ankit Sutaria, Longjian Liu, Ziauddin Ahmed
BACKGROUND: Few studies have examined whether there was an independent association between multiple medication use and risk of chronic kidney disease (CKD), with adjustment for cardiometabolic factors. In the study, we aimed to examine this association using a nationally representative sample in CKD patients aged 60 and older. METHODS: In the study, subjects aged ⩾60 years (n = 1306) who participated in the 2011-2012 National Health and Nutrition Examination Survey were analyzed cross-sectionally...
August 2016: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/26920371/adverse-cardiovascular-events-in-acute-coronary-syndrome-with-indications-for-anticoagulation
#16
Stacey Knight, Raymond O McCubrey, Zhong Yuan, Scott C Woller, Benjamin D Horne, T Jared Bunch, Viet T Le, Roger M Mills, Joseph B Muhlestein
OBJECTIVES: Randomized acute coronary syndrome (ACS) trials testing various antithrombotic (AT) regimens have largely excluded patients with coexisting conditions and indications for anticoagulation (AC). The purpose of this study is to examine the 2-year clinical outcomes of patients with ACS with indication for AC due to venous thromboembolism (VTE) during hospitalization for the ACS event or a prior or new diagnosis of atrial fibrillation (AF) with a CHADS2 (Congestive heart failure; Hypertension; Age; Diabetes; previous ischemic Stroke) score ⩾2...
August 2016: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/26879197/the-association-of-severity-of-retinal-vascular-changes-and-cardiac-remodelling-in-systemic-hypertension
#17
Mary Varghese, Srilakshmi M Adhyapak, Tinku Thomas, Meera Sunder, Kiron Varghese
OBJECTIVES: The aim of the study was to explore the association between hypertensive retinopathy, grades of retinopathy and cardiac remodelling. METHODS: This was a cross-sectional observational study. A total of 500 consecutive hypertensive adults from the in-patient population were studied for the presence of hypertensive retinopathy by dilated fundoscopy. The presence of cardiac remodelling due to hypertension was studied both by electrocardiography (ECG) and echocardiography...
August 2016: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/26868288/edaravone-a-potent-free-radical-scavenger-and-a-calcium-channel-blocker-attenuate-isoproterenol-induced-myocardial-infarction-by-suppressing-oxidative-stress-apoptotic-signaling-and-ultrastructural-damage
#18
Md Quamrul Hassan, Md Sayeed Akhtar, Mohd Akhtar, Javed Ali, Syed Ehtaishamul Haque, Abul Kalam Najmi
OBJECTIVES: In the present study, we investigated whether combination therapy of low-dose benidipine with the potent free radical scavenger edaravone has a cardioprotective effect against isoproterenol (ISO)-induced myocardial infarction (MI) in Wistar rats. METHODS: Rats were pretreated with concurrent doses of benidipine and edaravone (1 μg/kg/day + 1 mg/kg/day and 3 μg/kg/day + 3 mg/kg/day) by intravenous (i.v.) and intraperitoneal (i.p.) routes respectively for 28 days, followed by MI induction using ISO (85 mg/kg) by subcutaneous route for two days at 24 h intervals...
August 2016: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/26857928/comparing-clinical-outcomes-for-a-twelve-month-trial-of-zotarolimus-and-everolimus-eluting-stents-in-patients-with-coronary-artery-disease-data-from-the-thcric-registry
#19
Hamid Reza Poorhoseini, Seyed Ebrahim Kassaian, Kianoosh Hoseini, Sepideh Saroukhani, Mojtaba Salarifar, Mohammad Alidoosti, Ebrahim Nematipour, Ali Mohammad Haji-Zeinali, Alireza Amirzadegan, Mir Hossein Seyyed Mohammadzadeh, Kamal Khadem Vatan, Hassan Aghajani, Mahmood Sheikh Fathollahi, Hamidreza Farrokh-Eslamlou
OBJECTIVES: New-generation coronary stents including zotarolimus- and everolimus-eluting stents (ZES and EES) have been shown to decrease the risk of restenosis. The purpose of this study was to compare the safety and efficacy of ZES and EES over a 12-month clinical follow up, in routine clinical practice. METHODS: This is an observational study in which 1029 consecutive patients treated with ZES (n = 669) or EES (n = 360) were enrolled. The study endpoint was major adverse cardiac events (MACE), defined as cardiac death, nonfatal myocardial infarction (MI), and target lesion or vessel revascularization at 12 months...
August 2016: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/26826170/early-recurrence-of-atrial-fibrillation-after-catheter-ablation-with-left-atrial-fibrosis-identified-at-cardiac-magnetic-resonance-by-late-gadolinium-enhancement
#20
Antonio Totaro, Graziapia Casavecchia, Matteo Gravina, Riccardo Ieva, Francesco Santoro, Massimo Grimaldi, Pier Luigi Pellegrino, Luca Macarini, Matteo Di Biase, Natale Daniele Brunetti
In patients with atrial fibrillation (AF), extensive atrial tissue fibrosis identified by delayed enhancement magnetic resonance imaging has been associated with early recurrence of AF after catheter ablation. We present a case of a patient with extensive atrial fibrosis and AF recurrence.The study of late gadolinium enhancement with cardiac magnetic resonance imaging in patients with AF could be a valuable noninvasive tool for the selection of patients suitable for successful catheter ablation.
August 2016: Therapeutic Advances in Cardiovascular Disease
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