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Clinical Respiratory Journal

Ali Zubairi, Huzaifa Ahmad, Maryam Hassan, Sajjad Sarwar, Aamir Abbas, Talha Shahzad, Irfan Muhammad
INTRODUCTION: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease (ILD) that predominantly affects older adults . IPF has the highest mortality burden of all ILDs. Data on mortality in patients with IPF is limited in developing countries. OBJECTIVES: To identify factors associated with mortality in patients with IPF at a tertiary care center in Pakistan. METHODS: A retrospective chart review was conducted at the Aga Khan University Hospital (AKUH) in Karachi, Pakistan from January 2005 to December 2015...
May 15, 2017: Clinical Respiratory Journal
Jianyu Yao, Tianze Zhang, Lili Zhang, Kaiyu Han, Linyou Zhang
INTRODUCTION: Both genetic and environmental factors are implicated in the pathogenesis of interstitial lung disease (ILD). Single-nucleotide polymorphisms (SNPs) in FOXP3 genes were implicated in the causation of some autoimmune diseases; however, association of these genes and ILD has not been reported. OBJECTIVES: To investigate whether FOXP3 polymorphisms are associated with ILD in a representative Chinese population. METHODS: 157 ILD patients and 170 healthy controls were recruited; SNPs were genotyped by the Sequenom MassARRAY platform and SHEsis was used to estimate the haplotype frequencies of SNPs...
May 15, 2017: Clinical Respiratory Journal
Linlin Wang, Yuanlin Song
BACKGROUND: Pneumonia is a major cause of morbidity and mortality of children. Zinc is known to play a central role in the immune system. The deficiency of zinc increased susceptibility to infectious diseases. OBJECTIVE: To investigate the clinical efficacy of zinc given as an adjunct therapy to the treatment of severe pneumonia. METHODS: The PubMed, Embase, MEDLINE(TM) , and the Cochrane Central Register of Controlled Trials were searched to identify all randomized, double-blind and placebo-controlled trials which evaluated the clinical efficacy of zinc given as an adjunct in the treatment of severe pneumonia and published between January 1966 and October 2015...
May 9, 2017: Clinical Respiratory Journal
Shinji Chiba, Yutaka Nakamura, Tomoki Mizuno, Kazuyuki Abe, Yosuke Horii, Hiromi Nagashima, Nobuhito Sasaki, Hiroyuki Kanno, Tatsuo Tanita, Kohei Yamauchi
Background Several gene variants are associated with a response to an inhaled corticosteroids (ICSs) treatment in patients with bronchial asthma. A variant of the glucocorticoid-induced transcript 1 (GLCCI1) genes has previously been associated with decreased lung function improvement upon treatment with inhaled corticosteroids in patients with bronchial asthma. Another report has also demonstrated that this genetic biomarker did not influence the change in flow volume in one second. However, no studies have considered the treatment content and the GLCCI1 variants...
May 9, 2017: Clinical Respiratory Journal
Feng Wang, Hongyan Hou, Hongmin Zhou, Shiji Wu, Lie Mao, Min Huang, Botao Yin, Jing Huang, Ziyong Sun
INTRODUCTION: Differentiation of tuberculoma from cancer in solitary pulmonary nodule or mass still remains a major challenge in diagnostic laboratories. OBJECTIVES: The objective of this study is to determine the performance of T-SPOT.TB assay in discriminating these two diseases. METHODS: We prospectively enrolled 331 patients with a solitary pulmonary nodule or mass on CT scans. Conventional tests and T-SPOT.TB assay were simultaneously performed in all participants...
May 9, 2017: Clinical Respiratory Journal
Wei Luo, Qiaoli Chen, Ruchong Chen, Yanqing Xie, Hui Wang, Kefang Lai
PURPOSE: To establish the reference value of total and differential cell counts in induced sputum in healthy adults in Guangzhou, and to explore the relationship of age and gender with sputum cell counts. METHODS: A total of 185 healthy, nonatopic, never-smokers between 19 and 74 years old underwent induced sputum test with hypertonic saline (3%) inhalation. Sputum samples were collected for total and differential cell counts. RESULTS: Qualified sputum samples were obtained from 153 subjects (mean age: 43±17) with a success rate of 82...
May 2, 2017: Clinical Respiratory Journal
Enrica Capelletto, Simonetta Grazia Rapetti, Sara Demichelis, Domenico Galetta, Annamaria Catino, Donata Ricci, Anna Maria Moretti, Emilio Bria, Sara Pilotto, Arianna Bruno, Giuseppe Valmadre, Gian Piero Bandelli, Rocco Trisolini, Martina Gianetta, Maria Vittoria Pacchiana, Stefania Vallone, Silvia Novello
INTRODUCTION: Smoking is the major risk factor for cancer and several respiratory diseases. Quitting smoking at any point of life may increase the effectiveness of treatments and improve prognosis of patients with any pulmonary disease, including lung cancer. However, few institutions in Europe offer to patients adequate counseling for smoking cessation. OBJECTIVES: Aim of this study was to investigate the level of counseling for smoking cessation offered by healthcare professionals to patients and their appreciation towards the intervention itself...
May 2, 2017: Clinical Respiratory Journal
Yewande E Odeyemi, Edris Meda, Funmilola Ogundipe, Alem Mehari, Thomas Obisesan, Richard F Gillum
OBJECTIVE: To test the hypothesis that cognitive impairment increases mortality independent of airflow obstruction. MATERIALS AND METHODS: In 1988-1994 the Third National Health and Nutrition Examination Survey (NHANES III) measured forced expiratory volume in the first second (FEV1) and the forced vital capacity (FVC) and selected items on cognitive function with mortality follow-up. For this survival analysis 4,365 persons aged 60 and over with complete data formed the analytic sample...
April 29, 2017: Clinical Respiratory Journal
Yan Xu, Wenbing Xu, Yongjian Liu, Xinlun Tian, Kaifeng Xu, Juhong Shi, Mengzhao Wang, Baiqiang Cai, Min Peng
INTRODUCTION: Both fibrosing mediastinitis (FM) and bronchial anthracofibrosis (BAF) are unique diseases. The combined appearance of FM and BAF is extremely rare. OBJECTIVES: The aim of this study was to investigate the clinical features of patients with coexisting FM and BAF. METHOD: Between January 2003 and December 2015, a total of eight patients were diagnosed at the Peking Union Medical College Hospital as having combined FM and BAF. The clinical presentations, radiographic features, and bronchoscopic findings of the eight patients were reviewed...
April 17, 2017: Clinical Respiratory Journal
Chaosheng Deng, Shuang Wu, Lina Zhang, Minxia Yang, Qichang Lin, Qiang Xie, Haibo Ding, Ningfang Lian, Shaoyong Gao, Yunjian Huang, Yongxu Jin
Background To examine the expression of D-dimer, fibrinogen (FIB), leukocyte, C-reactive protein (CRP) and tissue factor (TF) released from monocyte in non-small cell lung cancer (NSCLC) patients with or without venous thromboembolism (VTE) and analyze the correlation, to explore the possible mechanisms. Methods Seventy two patients confirmed the diagnosis of lung cancer, among whom 10 with VTE were enrolled into the study from November 2012 to January 2014 in the First Affiliated Hospital of Fujian Medical University, 30 healthy subjects were also enrolled as the control group...
April 17, 2017: Clinical Respiratory Journal
Irappa Madabhavi, Swaroop Revannasiddaiah, Malay Sarkar
No abstract text is available yet for this article.
April 17, 2017: Clinical Respiratory Journal
Meirong Liu, Shuxiang Yang, Xiaofeng Tan
INTRODUCTION: Tartrate-resistant acid phosphatase 5 (ACP5), which is essential for bone resorption and osteoclast differentiation, promotes cell motility through the modulation of focal adhesion kinase phosphorylation. This study seeks to elucidate the association of ACP5 expression and the clinicopathologic characteristics of patients with lung adenocarcinoma Methods: The expression of ACP5 was measured by Immunohistochemistry and Western blot analysis in lung adenocarcinoma and matched tumor-adjacent tissues, and the χ2 test was applied to analyze the correlation between ACP5 expression and clinicopathologic features...
April 11, 2017: Clinical Respiratory Journal
Fangge Deng, Qing Tang, Mei Jiang, Nanshan Zhong, Guanghua Liu
BACKGROUND AND OBJECTIVE: Infrared thermal imaging (IRTI) is a new technique for detecting deep vein thrombosis (DVT) based on DVT's infrared presentation and distribution characteristics (PDCs). A method that is singularly sensitive to DVT is needed. They, therefore, enrolled 157 subjects with suspected lower extremity DVT in a double-blind, controlled clinical trial using IRTI, and Doppler compression ultrasonography (CPUS) to verify the clinical value of IRTI. METHODS: An IRTI system could precisely measure and store real-time thermal images...
April 11, 2017: Clinical Respiratory Journal
A B Schulze, L H Schmidt, L Baie, B Heitkötter, A Kümmel, M Mohr, R Buhl, H Hillmann, G Geißler, R Kelsch, D Görlich, W E Berdel, W Hartmann, R Wiewrodt
OBJECTIVES: The influence of blood group antigens on cancerogenesis is shown for distinct tumor types, yet the impact of Rhesus blood group antigens in lung cancer is not clarified. MATERIALS AND METHODS: To investigate the impact of Rhesus blood groups a non-small cell lung cancer (NSCLC) collective (n=1,047) was analyzed retrospectively. Using a second cohort of n=340 primarily operated stage I-III NSCLC patients, we evaluated immunohistochemistry of CD47-antibody stained tissue samples in correlation to histopathologic subtype and Rhesus blood group...
April 11, 2017: Clinical Respiratory Journal
Nikolai Stenfors, Erik Dyb Liaaen, Anne H Henriksen
INTRODUCTION: Very few studies have compared long-term mortality in pneumonic (pAECOPD) vs non-pneumonic (npAECOPD) acute exacerbations of chronic obstructive pulmonary disease (COPD). OBJECTIVE: To compare long-term survival in patients with pAECOPD and npAECOPD. METHODS: We conducted a retrospective audit study of all hospitalizations for COPD from 1 January to 31 December 2005 in three Scandinavian hospitals. Study inclusion criteria were patients discharged with one of the following ICD-10 discharge diagnoses: (1) primary diagnoses J43-J44 (emphysema or COPD) irrespective of secondary diagnosis; (2) main diagnosis J96 (respiratory insufficiency) + secondary diagnosis J44 (COPD) and (3) main diagnosis J13-18 (pneumonia) + secondary diagnosis J44 (COPD)...
April 1, 2017: Clinical Respiratory Journal
Tomohiro Tamura, Hiroaki Satoh
No abstract text is available yet for this article.
April 1, 2017: Clinical Respiratory Journal
Lu Che, Li Xu
No abstract text is available yet for this article.
April 1, 2017: Clinical Respiratory Journal
Tomohiro Tamura, Katsunori Kagohashi, Hiroaki Satoh
No abstract text is available yet for this article.
April 1, 2017: Clinical Respiratory Journal
Omar Abdel-Rahman
BACKGROUND: Small cell lung cancer (SCLC) is a distinct clinical and pathological entity within the spectrum of lung cancer. It was observed that the relative age distribution of the disease changed over years. METHODS: Surveillance, epidemiology, and end results (SEER) database (1973-2013) was utilized to determine the incidence, presentation and treatment outcomes of elderly patients (>70 years) with SCLC. Join point regression analysis was then conducted to analyze age-adjusted trends in incidence for the elderly as well as the whole SCLC population...
April 1, 2017: Clinical Respiratory Journal
Meihua Qiu, Yuqing Chen, Qiao Ye
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive fibrotic disease limited to the lungs. The course of disease varies widely, with some patients experiencing acute respiratory deterioration, a condition called acute exacerbations of IPF (AE-IPF). The risk factors contributing to AE-IPF are unclear. This systematic review and meta-analysis investigated the risk factors for AE-IPF. METHODS: Studies of risk factors for AE-IPF were identified in Medline, EMBASE and Cochrane databases...
March 23, 2017: Clinical Respiratory Journal
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