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Clinical Respiratory Journal

Huang Huang, Yan Shi, Jietao Huang, Xiaohui Wang, Rui Zhang, Hong Chen
OBJECTIVES: Accumulating evidences demonstrated that circulating tumor cells (CTCs) show significant high concentration in plasma of lung cancer patients compared to control cohorts, suggesting that CTCs may be a promising biomarker for lung cancer. The meta-analysis was used to evaluate potential diagnostic value of CTCs in diagnosing lung cancer. METHODS: Relevant literatures were searched in PubMed, Embase, Cochrane Library, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Technology of Chongqing (VIP), and Wan Fang Data...
October 25, 2016: Clinical Respiratory Journal
Mehrnaz Asadi Gharabaghi
BACKGROUND/AIM: Lung cancer is the major contributor to overall cancer-related mortality. Biomarkers are important in early detection and prognosis, in addition to developing treatment regimes, which may improve the patient survival rates. Therefore, the present study was designed to evaluate the prognostic and diagnostic value of SIRT1/BIRC6 expression in non-small cell lung cancer (NSCLC) Methods: The data on the prognostic impact of SIRT1/BIRC6 in NSCLC were collected from 11 September 2006 to 10 July 2014...
October 21, 2016: Clinical Respiratory Journal
Li Gao, Sheng Xie, Hui Liu, Pingping Liu, Yan Xiong, Jiping Da, Chengli Que, Huaping Dai, Chen Wang
OBJECTIVE: Combined pulmonary fibrosis and emphysema (CPFE) is a newly defined entity that comprises upper lobe emphysema and lower lobe fibrosis. Patients with CPFE are at high risk for lung cancer and have poor prognoses. To investigate the clinical and pathological characteristics of lung cancer with CPFE, lung cancers with CPFE and Non-CPFE interstitial lung disease (ILD) were reevaluated by 2015 WHO classification and compared. METHODS: A total of 60 patients with histologically proven lung cancer were selected from the database of two institutional medical centers...
October 21, 2016: Clinical Respiratory Journal
Berna Akıncı Özyürek, Özlem Özmen, Tuğçe Şahin Özdemirel, Yurdanur Erdoğan, Bekir Kaplan, Tuğba Kaplan
The aim of this study was to evaluate the relationship of the pre-treatment blood neutrophil/lymphocyte count ratio (NLR) with the maximum standard uptake value (SUVmax) of primary masses on positron emission tomography/computed tomography (PET/CT) taken before treatment in patients diagnosed with malignant pleural mesothelioma (MPM) and to evaluate the contribution to prognosis. A retrospective evaluation was made of 73 patients diagnosed with MPM in our hospital between January 2006 and January 2014. The SUVmax value of the primary mass on pre-treatment PET/CT, the haemogram parameters (Hb, Hct, NLR, MPV, PLT) at the time of diagnosis, the progression history, the date of the final visit and the date of death of exitus patients was recorted from patient files PET/CT...
October 21, 2016: Clinical Respiratory Journal
Carol A Kelly, Dave Lynes, Mary R O'Brien, Ben Shaw
BACKGROUND: Despite emerging evidence and guidelines, poor prescribing and administration of oxygen therapy persists. This study aimed to explore healthcare professionals' (HCPs) and patients' perceptions of oxygen. DESIGN: Semi-structured interviews with 28 patients and 34 HCPs. FINDINGS: Three master themes uncovered: oxygen as a panacea, the burden of oxygen, and antecedents to beliefs. Patients used oxygen for breathlessness and as an enabler; they were grateful to oxygen and accepted it as part of the disease...
October 12, 2016: Clinical Respiratory Journal
Toujani Sonia, Mjid Meriem, Ouahchi Yacine, Ben Salah Nozha, Mhiri Nadia, Louzir Bechir, Daghfous Jalloul, Chérif Jouda, Béji Majed
BACKGROUND: Asthma and rhinitis are a major public health problem because of their frequency, their impact on quality of life and economic burden. In Tunisia, epidemiological data are scarce. The aim of the present study was to estimate the prevalence of asthma and rhinitis in a representative Tunisian population and to analyze the association between them. METHODS: It was a cross-sectional population-based study, involving individuals aged between 2 and 52 years, living in Tunis...
October 12, 2016: Clinical Respiratory Journal
Wei Tang, Jun Zhou, Lili Miao, GuoCao Shi
OBJECTIVE: Cough variant asthma (CVA) is a subtype of asthma that is characterized by a chronic cough. We compared the clinical characteristics and pulmonary function in patients with CVA who had normal and high exhaled fractional nitric oxide (FeNO) levels. METHODS: We collected the clinical history and pulmonary function data from 99 patients with newly diagnosed CVA. RESULT: Newly diagnosed subjects with CVA were divided into a high FeNO group (FeNO value over or equal to 25 ppb, n=52) and a normal FeNO group (FeNO lower than 25 ppb, n=47)...
October 12, 2016: Clinical Respiratory Journal
Ping Zhan, Xiao Chen, Xiao-Yuan Wu, Zhi-Bo Hou, Qian Qian, Yu Zhang, Jue Zou, Yuan-Qing Zhang, Ming-Yue Wan, Jian-Dong Wang, Li-Ke Yu, Hai-Yan Xie
INTRODUCTION: For thymic carcinoma (TC), which is a rare epithelial neoplasm of the thymus gland, median survival with current treatments is only 2 years. OBJECTIVES: Mutations in the epidermal growth factor receptor (EGFR) gene or its downstream effectors may cause constitutive activation that leads to cell proliferation and metastases. Thus, molecular profiling is essential for selecting TC patients who may respond to anti-EGFR therapies. METHODS: Genomic DNA was extracted from 61 histological samples of TCs...
October 12, 2016: Clinical Respiratory Journal
Yu Lin Tsai, Wang-Sheng Ko, Jung-Lung Hsiao, Hsin-Hung Pan, Ya-Ling Chiou
INTRODUCTION: In the pathogenesis of asthma, an imbalance between helper T (Th) 1/Th2 and Th17/Treg cells is believed to play a key role in asthmatic inflammatory responses. Some studies indicated that zinc deficiency increases inflammatory factor production and worsens asthma. However, the effects of zinc on T cell profiles to reduce inflammatory response remain unclear Objectives: We investigated the beneficial effects of zinc on isolated cell populations and cytokine levels from patients with asthma...
October 11, 2016: Clinical Respiratory Journal
Ahmet Goktug Ertem, Cagri Yayla, Burak Acar, Ozgur Kirbas, Sefa Unal, Melahat Uzel Sener, Mehmet Kadri Akboga, Tolga Han Efe, Serkan Sivri, Fatih Sen, Serkan Gokaslan, Serkan Topaloglu
INTRODUCTION: The relationship between inflammation and mortality after acute pulmonary embolism (APE) has previously been investigated with different variables (platelet/lymphocyte ratio, etc). OBJECTIVES: We investigated the predictive value of lymphocyte to monocyte ratio (LMR) for mortality in first 30 days after APE. METHODS: The study population included 264 APE patients of which 230 patients were survivors, 34 patients were non-survivors...
October 11, 2016: Clinical Respiratory Journal
Zheng Zhu, Yanqing Xie, Weijie Guan, Yi Gao, Shu Xia, Rongquan Huang, Nanshan Zhong, Jinping Zheng
Background Both histamine and leukotrienes are implicated in the pathogenesis of allergic rhinitis (AR), although the pattern and severity of the nasal response to these two potent inflammatory mediators may differ, which has not been adequately studied in patients with persistent AR. Objective We sought to compare the differential effects of nasal challenge with leukotriene D4 (LTD4 ) and histamine on the airway response and inflammation in patients with AR. Methods An open-label, crossover study was performed in 25 persistent AR patients (AR group) and 16 healthy subjects (control group)...
October 3, 2016: Clinical Respiratory Journal
Hana Bartáková, Jan Novák, Radek Jakša, Jiří Beneš, Jiří Votruba
Pulmonary infiltration is an infrequent organ involvement in Waldenström's disease (WD). Diffuse infiltration, isolated parenchymatous nodules and pleural effusion are the most common manifestations of WD, while endobronchial mass is extremely rare. We present a case report of a 66-year-old man with a long-standing history of WD, who developed febrile neutropenia after therapy with rituximab, cyclophosphamide and dexamethasone. X-ray and CT scan showed consolidation consistent with right-sided pneumonia. Surprisingly, bronchoscopy revealed an endobronchial tumor obstructing the right lower lobe (RLL) and two smaller granulations...
October 3, 2016: Clinical Respiratory Journal
Mengxi Li, Shouyang Wang, Weiquan Lin, Jinhui Li, Chunyang Wang, Huai Chen, Wenju Lu, Kai Yang, Jian Wang, Qingsi Zeng
OBJECTIVE: To develop a formula to compute mean pulmonary arterial pressure (MPAP) by chest computerized tomography (CT), and to verify its accuracy and reliability. METHODS: 85 patients who had taken chest CT and right heart catheterization (RHC) were recruited. The pulmonary arterial systolic pressure (PASP), pulmonary arterial diastolic pressure (PADP) and MPAP of each subject were measured and recorded by right heart catheterization (RHC). The diameters of the ascending aorta (dAA), descending aorta (dDA) and main pulmonary artery (dMPA), Cobb angle, diameters of right ventricle (dRV), diameters of left ventricle (dLV) were measured by means of chest CT scans...
October 3, 2016: Clinical Respiratory Journal
Nozomu Motono, Sumiko Maeda, Ryumon Honda, Makoto Tanaka, Yuichiro Machida, Katsuo Usuda, Motoyasu Sagawa, Hidetaka Uramoto
BACKGROUND: The aim of the study was to examine the influence of the changes in the atmospheric temperature (ATemp) and the atmospheric pressure (APres) on the occurrence of a spontaneous pneumothorax (SP). PATIENTS AND METHODS: From January 2000 to March 2014, 192 consecutive SP events were examined. The ATemp and APres data at the onset of SP, as well as those data at 12, 24, 36, 48, 60, and 72 h prior to the onset time, were analyzed. RESULTS: The frequencies of SP occurrence were not statistically different according to the months or seasons, but were statistically different according to the time period (P < ...
September 26, 2016: Clinical Respiratory Journal
Sheetu Singh, Bharat Bhushan Sharma, Sundeep Salvi, Jugesh Chhatwal, Kailash Chandra Jain, Lata Kumar, Mohan Keshav Joshi, Suresh Babu Pandramajal, Shally Awasthi, Sheila Bhave, Sylvan Rego, Thevaruparambil Unny Sukumaran, Vasant A Khatav, Virendra Singh, Surendra Kumar Sharma, Mohammed Sabir
OBJECTIVE: We aim to describe the data collected from India during phase 3 of the International study of asthma and allergy in childhood (ISAAC) study. Prevalence, severity, and population characteristics associated with rhinitis, rhinoconjunctivitis, and eczema were assessed. METHODS: Children from two age groups (6-7 and 13-14 years) were included in the study as per the ISAAC protocol. The symptoms of allergy and associated features were assessed using a questionnaire...
September 24, 2016: Clinical Respiratory Journal
Byung Ki Ahn, Yoon-Seon Lee, Youn-Jung Kim, Chang Hwan Sohn, Shin Ahn, Dong Woo Seo, Won Young Kim, Jae Ho Lee, Kyung Soo Lim
INTRODUCTION AND OBJECTIVES: We aimed to develop a new prediction model of mortality in cancer patients with pneumonia and to compare its performance with CURB-65 and the Pneumonia Severity Index (PSI). METHODS: Active cancer patients who were diagnosed with pneumonia at the Emergency Department (ED) from 7/1/2014 to 12/31/2014 were consecutively included. Clinical data were collected through a medical chart review. The primary outcome was the 28-day mortality, and clinical factors were analyzed using logistic regression analysis...
September 24, 2016: Clinical Respiratory Journal
Antonio Morais, Bruno Lima, Helena Alves, Natalia Melo, Patricia C Mota, Agostinho Marques, Luis Delgado
BACKGROUND: A genetic background may be responsible for the different clinical courses in sarcoidosis. We analyzed associations between sarcoidosis clinical course and HLA class I/II alleles and susceptibility gene SNPs ANXA11 rs1049550 C/T and BTNL2 rs2076530 G/A in a Portuguese population, investigating possible gene-gene interactions. METHODS: We studied 138 unrelated Caucasian sarcoidosis patients (78 women, 56.5%; mean age, 37.2 ± 12.1 years). Disease that persisted after 2 years was considered chronic...
September 24, 2016: Clinical Respiratory Journal
Giorgia A Osman, Alberto Ricci, Fabrizio Terzo, Carlo Falasca, Maria R Giovagnoli, Pierdonato Bruno, Andrea Vecchione, Salvatore Raffa, Sabatino Valente, Maria R Torrisi, Chiara De Dominicis, Simonetta Giovagnoli, Salvatore Mariotta
INTRODUCTION: Lipoid pneumonia is a clinical condition that may be initially asymptomatic or confused with an infectious or malignant lung disease. OBJECTIVES: We report four cases of this pathological condition. METHODS: The first case concerned an 85-year old woman with bilateral confluent pulmonary opacities, ground-glass type. Diagnosis was based on the cytology of the bronchoalveolar lavage (BAL) fluid followed by its ultrastructural examination...
September 22, 2016: Clinical Respiratory Journal
Katy E Mitchell, Vicki Johnson, Linzy Houchen-Wolloff, Louise Sewell, Mike D Morgan, Michael C Steiner, Sally J Singh
INTRODUCTION AND OBJECTIVES: There are various recommendations for physical activity (PA). However agreement between all of these measures has not been established. Furthermore, given the challenges of measuring PA there is interest in evaluating whether a measure of exercise performance can be used as a surrogate measure to identify who is likely to achieve the recommendations. METHODS: A total of 184 people with COPD were recruited, 128 of which had complete data for these analyses...
September 22, 2016: Clinical Respiratory Journal
Ayperi Ozturk, Nilgun Yilmaz Demirci, Zafer Aktas, Funda Demirag, Ali Alagoz, İbrahim Onur Alici, Aydın Yilmaz
BACKGROUND: Small cell lung cancer (SCLC) commonly presents as hilar/mediastinal masses. In some occasions, conventional flexible bronchoscopy fails and a substantial amount of time is lost until establishing the diagnosis. OBJECTIVE: The aim of the study was to demonstrate the superiority of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) compared to conventional methods in establishing the diagnosis as an initial modality as well as to point out the saved time until the diagnosis...
September 22, 2016: Clinical Respiratory Journal
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