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Clinical Respiratory Journal

Wen Wen, Lei Gu, GuoQing Yu, Ai Min Wang, Hua Zeng, Ping Yu, Wei Liu, DeSheng Jia, WenJie Xia, GuoXiang Lai, Wei Liu
BACKGROUND: Mycoplasmal pneumonia is a common type of adult community-acquired pneumonia in China, but round/spherical pneumonia caused by mycoplasma pneumoniae has rarely been reported. Here we report an outbreak of mycoplasmal round pneumonia in a military dormitory in China. METHODS: We analysed epidemiological, clinical, imaging and laboratory data from a series of adults affected by an outbreak of mycoplasmal round pneumonia in the dormitory of a military hospital (Fuzhou General Hospital) in Fuzhou, China...
November 12, 2018: Clinical Respiratory Journal
Sinem Ermin, Akın Çinkooğlu, Seher Susam, Özgür Batum, Ufuk Yılmaz
INTRODUCTION: Pulmonary thromboembolism(PTE) is a clinical condition that can result in sudden death. Computed tomography pulmonary angiography(CTPA) is the most sensitive imaging technique for the diagnosis of PTE. Filling defects in the pulmonary veins, which can be identified in areas adjacent to PTE, have been named the "pulmonary vein sign"(PVS). OBJECTIVES: The aim of our study is to determine the frequency, sensitivity, and specificity of PVS due to decreased venous drainage in the affected area in PTE patients...
October 20, 2018: Clinical Respiratory Journal
Yong-Hong Pan, Cai-Yu Lin, Cong-Hua Lu, Li Li, Yu-Bo Wang, Heng-Yi Chen, Yong He
PURPOSE: Third-generation irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), rociletinib(CO-1686), is great efficacy against EGFR-mutated patients bearing the T790M resistance mutation. However, acquired resistance may emerge. There is a need to characterize acquired resistance mechanism(s) and to devise ways to overcome CO-1686 resistance. EXPERIMENTAL DESIGN: MTT assay, ki67 incorporation assay, transwell assay and TUNEL assay were employed to analyze the effects of metformin to reverse CO-1686 resistance in vitro...
October 11, 2018: Clinical Respiratory Journal
A Orea-Tejeda, A Navarrete-Peñaloza, L Verdeja-Vendrell, A Jiménez-Cepeda, D González-Islas, R Hernández-Zenteno, C Keirns-Davis, R Sánchez-Santillán, A Velazquez-Montero, G A Puentes Rodríguez
BACKGROUND: The prognosis in patients with Chronic Obstructive Pulmonary Disease (COPD) depends in large part on the frequency of exacerbations. Cardiovascular diseases, including heart failure (HF), are risk factors for exacerbations. However, its unknown the importance of HF type over the exacerbations in COPD patients. OBJECTIVE: To determine whether right heart failure (RHF) is an independent risk factor for severe exacerbations in patients with COPD. METHODS: A prospective cohort study of 133 patients diagnosed with COPD with a follow-up period from 2010 to 2016...
October 11, 2018: Clinical Respiratory Journal
Safoura Sheikh Rezaei, Christoph Rinner, Paulina Ratajczak, Wilfried Grossmann, Walter Gall, Michael Wolzt
INTRODUCTION: Beta-blockers are indicated for secondary prevention of coronary artery disease (CAD). However, in patients with co-morbidity of chronic obstructive pulmonary disease (COPD) an under-use of beta-blocker has been reported. MATERIALS AND METHODS: Prescription and demographic data and information on hospital discharge diagnoses from 13 Austrian health insurance funds for the years 2006 to 2007 were analysed. The primary end point was all-cause mortality of patients with CAD with or without COPD and its association with use of beta-blockers...
October 1, 2018: Clinical Respiratory Journal
Regina Treudler, Samira Zeynalova, Toralf Kirsten, Christoph Engel, Markus Loeffler, Jan-Christoph Simon
No abstract text is available yet for this article.
September 28, 2018: Clinical Respiratory Journal
Tsung-Hsien Wang, Chin-Pyng Wu, Li-Ying Wang
BACKGROUND: Extubation failure can lead to a longer intensive care unit (ICU) stay, higher mortality rate, and higher risk of requiring tracheostomy. Chest physiotherapy (CPT) can help patients in reducing the accumulation of airway secretion, preventing collapsed lung, improving lung compliance, and reducing comorbidities. Much research has investigated the correlation between CPT and respiratory system clearance. However, few studies have investigated the correlation between CPT and failed ventilator extubation...
September 28, 2018: Clinical Respiratory Journal
Andrew C Berry, Nicholas A Berry, Bin Wang, Madhuri Mulekar, Anne Melvin, Richard J Battiola, Frederick K Bulacan, Bruce B Berry
Cough carries an annual prevalence in the population of 10-33% and remains the most common reason for primary care physician visits. Gastroesophageal reflux disease (GERD) is estimated to be present in 20-40% of Western adult populations. Pulmonary manifestations, such as cough, have been recognized as a potential consequence of GERD, with the prevalence of GERD-associated cough ranging from 10%-40%. This article is protected by copyright. All rights reserved.
September 27, 2018: Clinical Respiratory Journal
Jawad Abukhalaf, Ross Davidson, Nicolas Villalobos, Paula Meek, Hans Petersen, Akshay Sood, Yohannes Tesfaigzi, Rodrigo Vazquez Guillamet
BACKGROUND: Current risk factors for Chronic Obstructive Pulmonary Disease mortality focus only on overall and respiratory death. We investigated whether risk factors for each specific cause of mortality are different depending on the outcome under consideration. METHODS: This retrospective cohort study included patients with a clinical diagnosis of COPD, older than 40, greater than 20 pack-years smoking history, and obstructive pattern on spirometry. Collected data included baseline spirometry, comorbidities, medication use, tobacco exposure, severe exacerbations, and cause-specific mortality...
September 26, 2018: Clinical Respiratory Journal
Mariane Monteschi, Adriana Ignacio de Padua, Carla Riva Perez, Maria Vera Castellano, Simone Cedano, Antonio Luiz Rodrigues-Júnior, José Baddini-Martinez
BACKGROUND AND AIMS: Smokers exhibit a high prevalence of psychological abnormalities, and these factors may contribute to smoking initiation, its maintenance, and quitting difficulties. This study reports the development of a scale aiming at evaluating the emotional status of smokers in face of tobacco. METHODS: Levels of Anxiety, Depression, Perceived Stress, Self Esteem, and Loneliness of 120 smokers (age: 54.6 years; 74 women) were compared with those of 76 non smokers (age: 45...
September 26, 2018: Clinical Respiratory Journal
Francesco Gavelli, Filippo Patrucco
No abstract text is available yet for this article.
September 24, 2018: Clinical Respiratory Journal
Pervin Korkmaz Ekren, Nur Zehra Töreyin, Payam Nahid, Mert Doskaya, Ayse Caner, Nevin Turgay, Aysin Zeytinoglu, Seray Toz, Feza Bacakoglu, Yuksel Guruz, Selda Erensoy
INTRODUCTION: Impact of Cytomegalovirus (CMV) co-infection pneumonia in non-HIV patients with Pneumocystis jirovecii pneumonia (PCP) is unclear. OBJECTIVES: The aim of our study was to determine whether CMV co-infection is associated with an increased risk of mortality. METHODS: Our study was conducted at Ege University Hospital, Turkey. We used molecular assays to diagnose Pneumocystis jirovecii in respiratory samples, and CMV in both respiratory and blood samples...
September 23, 2018: Clinical Respiratory Journal
Li Ping Guo, Yan Jiang, Ying Mei Liu, Bin Cao
INTRODUCTION: China has a very high tuberculosis (TB) burden. The interferon-gamma release assay (IGRA) is more specific for the diagnosis of latent tuberculosis infection (LTBI) than the tuberculin skin test, especially among populations with a high degree of coverage by the BCG vaccine. OBJECTIVES: To evaluate the first screening of healthcare workers (HCW) for LTBI using the IGRA at a general hospital in Beijing. METHODS: A pilot screening program for LTBI was triggered by accidental contact between HCW and two patients with active TB in the emergency department (ED)...
September 19, 2018: Clinical Respiratory Journal
Sarah Ward, Louise Sewell, Sally Singh
INTRODUCTION: Pulmonary rehabilitation (PR) is a multidisciplinary program of care for patients with chronic respiratory disease. The educational component is an integral component and represents a large proportion of a program. However, it can be difficult to secure regular multidisciplinary input to PR programs. OBJECTIVES: This service evaluation assessed whether DVD presentations are acceptable to patients and effective as an education medium. METHOD: Two PR groups were compared; one group received education by DVD and the other by spoken talk...
September 17, 2018: Clinical Respiratory Journal
Hongyan Pang, Lei Wang, Jie Liu, Shengfeng Wang, Yuanhua Yang, Ting Yang, Chen Wang
INTRODUCTION: Venous thromboembolism (VTE) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is not rare, which would affect the patient's prognosis. OBJECTIVES: To examine the prevalence, risk factors and clinical characteristics of AECOPD patients with VTE. METHODS: We performed this multi-center, prospective, observational study that involved 16 hospitals in China. Patients admitted to hospital due to AECOPD were consecutively enrolled...
September 12, 2018: Clinical Respiratory Journal
Yake Yao, Hua Zhou, Yihong Shen, Qing Yang, Jian Ye, Yiqi Fu, Guohua Lu, Haiyan Lou, Yunsong Yu, Jianying Zhou
BACKGROUND: The early diagnosis of chronic pulmonary aspergillosis (CPA) remains challenging. Currently, a new quantitative IgM antibody assay that enveloped purified galactomannan extracted from Aspergillus fumigatus as antigen was commercially available in China, but its diagnostic value remains to be established. METHODS: To evaluate the role of this commercial IgM assay for diagnosis of CPA, a multi-center prospective study was performed in 12 hospitals in Zhejiang Province, from January 1 to December 31, 2016...
September 6, 2018: Clinical Respiratory Journal
Erika Cavalheiro Skupien, Tássia Kirchmann Lazzari, Sandra Eugênia Coutinho, Denise Rossato Silva
BACKGROUND: Muscle weakness is a part of the wasting syndrome associated with TB. Cytokines are candidates as the initial causative agents of the metabolic changes in TB. The objective of this study is to assess the peripheral and respiratory muscle strength in patients with TB and controls and relate these findings with leptin, IL-6 and TNF-α serum levels. METHODS: Case-control study. Hospitalized patients with pulmonary TB and controls were included. Maximal voluntary handgrip strength (HS), maximal inspiratory pressure (MIP) and maximum expiratory pressure (MEP) were measured...
September 4, 2018: Clinical Respiratory Journal
Yongping Yu, Li Yang, Yuhai Zhang, Liang Dong, Jingwen Xia, Ning Zhu, Xinpeng Han, Liying Fang, Yaqin Chai, Mengjie Niu, Lingli Liu, Xuemin Yang, Shuoyao Qu, Shengqing Li
BACKGROUND: The incidence and risk factors of chronic thromboembolic pulmonary hypertension (CTEPH) in patients with acute pulmonary embolism (PE) have been well reported. However, in real world, patients diagnosed with PE for the first time were usually composed of acute PE, sub-acute PE, and chronic PE, and the cumulative incidence and risk factors of CTEPH in this cohort were still unknown. METHODS: A prospective, long-term, follow-up study was conducted to assess the incidence of symptomatic CTEPH in consecutive patients with PE diagnosed for the first time...
August 30, 2018: Clinical Respiratory Journal
Julien Guinde, Samer Georges, Valerian Bourinet, Sophie Laroumagne, Herve Dutau, Philippe Astoul
OBJECTIVE: Metastatic pleural effusion (MPE) is one of the most frequent causes of pleural effusion. The aims of the therapeutic management are palliation of symptoms and improvement in patient's quality of life. The first step is a therapeutic thoracentesis. In case of a recurrent MPE, pleural maneuvers can be used to manage symptoms based on either ambulatory pleural drainage or pleurodesis to prevent fluid accumulation. The aim of this review is to describe recent advances, according to the best available evidence, in the field of pleurodesis for the management of MPE...
October 2018: Clinical Respiratory Journal
Xiaoyan Chen, Jinguo Liu, Mengchan Zhu, Bijie Hu, Fengxi Bai, Wenting Jin, Jian Zhou, Cuicui Chen, Yuanlin Song, Jue Pan
BACKGROUND: Progranulin is a pleiotropic glycosylated protein precursor that plays an important role in inflammation. Limited data exist regarding the role of progranulin in the acute exacerbation of chronic obstructive pulmonary disease (AECOPD). OBJECTIVES: The study is to assess the efficiency of progranulin as a circulating biomarker of AECOPD. METHODS: The plasma progranulin levels were measured and compared in patients with AECOPD (n = 52), patients with stable COPD (n = 56), and healthy controls (n = 36)...
October 2018: Clinical Respiratory Journal
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