Read by QxMD icon Read

Clinical Respiratory Journal

Xiaoxing Wen, Bingping Wang, Tao Feng, Wei Yuan, Jian Zhou, Tao Fang
BACKGROUND AND AIM: Non-small cell lung cancer (NSCLC), which comprises 80-85% of all lung cancer cases, is one of the most common human malignancies. Despite great improvements in diagnostic technology and the introduction of new therapeutic agents in recent years, the 5-year survival rate of NSCLC is still low. Tumor necrosis factor (TNF) receptor-associated factor 1 (TRAF1) plays an important role in the TNF-related apoptosis-inducing ligand (TRAIL) associated signal pathway. METHODS: In this study, we aim to illuminate the function of TRAF1 in NSCLC...
March 12, 2018: Clinical Respiratory Journal
Xin-Liang Gao, Si-Si Wang, Dian-Bo Cao, Wei Liu
Introduction Elevated plasma D-dimer levels have been suggested as a predictor of poor prognosis in NSCLC. But rare study showed the relationship between d-dimer levels and lymph node involvement. Objectives To evaluate the role of plasma D-dimer levels in predicting lymph node and mediastinal lymph node involvement in NSCLC. Methods Preoperative plasma D-dimer levels were quantified in 253 NSCLC patients that underwent radical lung resection with systemic lymph node dissection. Patients were classified as lymph node negative (N0) vs...
March 2, 2018: Clinical Respiratory Journal
Songul Ozyurt, Savas Ozsu, Muge Erbay, Funda Oztuna, Aziz Gumus, Unal Sahin
INTRODUCTION: Syncope is infrequent in pulmonary thromboembolism (PTE) yet might be indicative of haemodynamic instability. The prognostic role of syncope in PTE has not been well documented. OBJECTIVES: In this study, the association between risk classification of the European Society of Cardiology and syncope was investigated in the normotensive PTE patients. METHODS: We retrospectively screened electronic medical records of patients who were admitted in two tertiary care hospital and diagnosis of PTE with computed tomography pulmonary angiography...
March 2, 2018: Clinical Respiratory Journal
Sami Deniz, Hülya Şahin, Enver Yalnız
INTRODUCTION: Reduced exercise capacity is a main feature of Interstitial Lung Diseases (ILDs) and it is related to closely prognosis of these patients. Pulmonary Rehabilitation (PR) results to improve in peak exercise capacity, dyspnea and quality of life in ILDs. OBJECTIVES: We aimed to evaluate the benefits of PR in patients with ILDs and to determine whether there are similar gains in patients with severe ILD. METHODS: We recruited ILD stable patients...
March 2, 2018: Clinical Respiratory Journal
Alkesh Kumar Khurana, Deepti Joshi, Abhishek Goyal, Ujjawal Khurana
No abstract text is available yet for this article.
March 2, 2018: Clinical Respiratory Journal
Francesca Lucca, Margherita Guarnieri, Mirco Ros, Giovanna Muffato, Roberto Rigoli, Liviana Da Dalt
INTRODUCTION: Pseudomonas aeruginosa is the predominant pathogen responsible of chronic colonization of the airways in Cystic Fibrosis patients. There are few European data about antibiotic susceptibility evolution of Pseudomonas aeruginosa in Cystic Fibrosis patients. OBJECTIVES: The aim of this study is to evaluate the evolution of antibiotic resistance in the period 2010-2013 in Cystic Fibrosis patients chronically colonized by Pseudomonas aeruginosa and to highlight the characteristics of this evolution in patients younger than 20 years...
March 2, 2018: Clinical Respiratory Journal
Fernando Carlos Vetromille Ribeiro, Agnaldo José Lopes, Pedro Lopes de Melo
INTRODUCTION: The Forced oscillation technique (FOT) is a particularly useful test of the mechanical properties of the respiratory system that has an increasingly important role in lung function laboratories. There is general agreement in the literature that the determination of reference values is of utmost importance in the clinical use of the FOT. OBJECTIVE: Our aim was to present reference values for whole-breath FOT measurements, establish which anthropometric variables were more predictive of impedance parameters, and provide all the details to adequately adopt these reference equations in individual laboratories...
February 22, 2018: Clinical Respiratory Journal
Win Sen Kuan, Simon Craig, Anne-Maree Kelly, Gerben Keijzers, Sharon Klim, Colin A Graham, Peter Jones, Anna Holdgate, Charles Lawoko, Said Laribi
INTRODUCTION: Shortness of breath is a common presenting symptom to the emergency department (ED) that can arise from a myriad of possible diagnoses. Asthma is one of the major causes. OBJECTIVE: To describe the demographic features, clinical characteristics, management and outcomes of adults with an emergency department (ED) diagnosis of asthma who presented to an ED in the Asia Pacific region with a principal symptom of dyspnea. METHODS: Planned sub-study of patients with an ED diagnosis of asthma identified in the Asia, Australia and New Zealand Dyspnoea in Emergency Departments (AANZDEM) study...
February 22, 2018: Clinical Respiratory Journal
Jorine E Hartman, Karin Klooster, Nick H T Ten Hacken, Dirk-Jan Slebos
To our knowledge, this is the first study to investigate patient-specific goals before and after coil treatment in severe emphysema. Thirteen patients reported in the Patient-Specific-Complaints-questionnaire their personal 3 most important treatment goals, and scored on a VAS-scale (0-10) the level of disability per activity before and 1 year after treatment. Most frequently reported goals were walking(n=12), taking a shower/washing(n=5) and cycling(n=3). The combined VAS-score of all 3 reported goals significantly decreased from median 24 to 16 points (-33%)...
February 13, 2018: Clinical Respiratory Journal
Seyed Masoom Masoompour, Hamideh Mahdaviazad, Seiyed Mohammad Ali Ghayumi
OBJECTIVE: This study aimed to explore the association between the prevalence of asthma and socio-economic factors using data from the Shiraz Adult Respiratory Disease Study, 2015(SARDS). METHODS: The SARDS was conducted from June to October 2015 among adult subjects of the general population of Shiraz, Iran. Current asthma was defined as the presence of at least one of the following factors in the preceding 12 months: 1) being awakened by an attack of shortness of breath, coughing, or chest tightness without any identifiable cause; 2) having an asthma attack; 3) currently using medication for asthma; or 4) having wheezing or whistling in the chest not associated with a cold or the flu...
February 13, 2018: Clinical Respiratory Journal
Viboon Boonsarngsuk, Khattiya Mangkang, Pitak Santinirand
BACKGROUND: Physicians are usually aware of the occurrence of drug-resistant (DR) pulmonary tuberculosis (PTB), but lack concern about DR-extrapulmonary TB (EPTB). Data regarding the prevalence and risk factors of DR-EPTB remain limited. OBJECTIVES: To determine the prevalence and risk factors of DR-EPTB. METHODS: A retrospective study was performed in patients who had culture-proven Mycobacterium tuberculosis (MTB) from various specimens between January 2013 and December 2015...
February 9, 2018: Clinical Respiratory Journal
Omar Abdel-Rahman
BACKGROUND: Malignant mesothelioma is an aggressive malignancy that is predisposed to through asbestos exposure. Little is known about the extent to which asbestos use ban has affected global trends in malignant mesothelioma. The current study investigated recent global mortality trends of malignant mesothelioma. METHODS: Data were collected from International Agency for Research on Cancer/World Health Organization mortality database to examine age-standardized, gender-specific mortality rates for malignant mesothelioma (ICD10-C45)...
February 9, 2018: Clinical Respiratory Journal
Paschalis Ntolios, Eleni Manoloudi, Argyris Tzouvelekis, Evangelos Bouros, Pachalis Steiropoulos, Stavros Anevlavis, Demosthenes Bouros, Marios E Froudarakis
BACKGROUND: Cell based therapies have been used for the management of several diseases, holding promising results. Few studies have evaluated their use in chronic lung diseases. Idiopathic Pulmonary Fibrosis (IPF) remains a lethal disease, although new therapies have emerged the recent years. We have recently published a phase I study of 14 patients receiving endobronchially Adipose-Derived Stem Cells (ADSCs). The aim of the current report is to assess the outcome for our patient population...
February 7, 2018: Clinical Respiratory Journal
Mehdi Varmaghani, Abbas Kebriaeezadeh, Farshad Sharifi, Ali Sheidaei, Arash Rashidian, Maziar Moradi-Lakeh, Roozbeh Naghshin, Mostafa Moin, Parinaz Mehdipour, Elham Heidari, Kimiya Gohari, Nazila Rezaei, Rosa Haghshenas, Farzad Kompani, Farshad Farzadfar
BACKGROUND: Asthma and COPD could be considered as a major health problem in industrialized and developing countries. The present study was designed to analyze the trends of mortality from asthma and COPD at national and sub-national levels in Iran based on national death registry, from 2001 to 2015. METHODS: We used Death Registration System (DRS) as the basic source of data. DRS data were available from 1995 to 2010 in Iran's Ministry of Health. Although, Tehran and Isfahan, two most populated cities in Iran, had independent death registry systems in their cemeteries, by combining their data we achieved more comprehensive and representative data on death among Iranian people...
February 5, 2018: Clinical Respiratory Journal
Xinwang Chen, Zhenguo Zhai, Ke Huang, Wanmu Xie, Jun Wan, Chen Wang
BACKGROUND AND OBJECTIVE: Bosentan therapy has been recommended for pulmonary arterial hypertension (PAH) and might be beneficial for chronic thromboembolic pulmonary hypertension (CTEPH). We aimed to evaluate the specific effects of bosentan for PAH and CTEPH. MATERIALS AND METHODS: We performed a systemic review and meta-analysis of randomized controlled trials (RCTs), comparing efficacy and safety of bosentan treatment for PAH and CTEPH through major biomedical database...
February 2, 2018: Clinical Respiratory Journal
Mohammad Saud Khan, Faisal Khateeb, Jamal Akhtar, Zubair Khan, Amos Lal, Veronika Kholodovych, Jeffrey Hammersley
BACKGROUND AND OBJECTIVES: Electronic cigarettes (e cigarettes) are battery operated devices that produce aerosol by heating a solution typically made up of nicotine, propylene glycol, glycerin and flavoring agents. The use of e cigarettes has risen dramatically in recent years especially among adolescents and young adults. These devices have been marketed as safer alternatives to tobacco smoking by their manufactures despite lack of adequate safety data. METHODS: We present a case of 40-year-old female patient who developed significant pulmonary toxicity secondary to e cigarette use and searched existing literature relevant to the case...
February 2, 2018: Clinical Respiratory Journal
Aroub Lahham, Christine F McDonald, Ajay Mahal, Annemarie Lee, Catherine J Hill, Angela T Burge, Narelle S Cox, Rosemary Moore, Caroline Nicolson, Paul D O'Halloran, Rebecca Gillies, Anne E Holland
INTRODUCTION: Evaluating adherence to home-based pulmonary rehabilitation (PR) could be challenging due to lack of direct supervision and the complex nature of the rehabilitation model. To measure adherence to home-based PR in the HomeBase trial, participants were encouraged to work towards a goal of at least 30 minutes of whole-body exercise on most days of the week and report their participation using a home exercise diary. OBJECTIVE: This project aimed to evaluate the acceptability and validity of the home exercise diary...
February 2, 2018: Clinical Respiratory Journal
Myoung Kyu Lee, Jaehwa Choi, Bonil Park, Bumjoon Kim, Seok Jeong Lee, Sang-Ha Kim, Suk Joong Yong, Eun Hee Choi, Won-Yeon Lee
INTRODUCTION: Severe acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a significant event that results in substantial mortality. OBJECTIVES: We evaluated the effectiveness of the high flow nasal cannulae (HFNC) therapy in severe AECOPD with moderate hypercapnic acute respiratory failure (ARF) compared to non-invasive ventilation (NIV). METHODS: The prospective observational trial was performed to compare the effectiveness between the HFNC and NIV in severe AECOPD with moderate hypercapnic ARF...
February 2, 2018: Clinical Respiratory Journal
Wentao Li, Houwen Zheng, Huichan Qin, Guangnan Liu, Ke Lan, Yu Li, Na Li, Xiaoning Zhong
Background Lung adenocarcinoma is characterized by early asymptomatic progression and metastasis. Appearance of respiratory symptoms usually means the disease is aggravated. The aim of this study was to identify the protein profile in plasma of lung adenocarcinoma of stages I-IV, and look for novel diagnostic biomarkers. Methods Isobaric tags for relative and absolute quantitation (iTRAQ) coupled with two dimensional liquid chromatography - tandem mass spectrometry technology (2D LC-MS/MS) was applied to separate and identify differential expression of proteins in plasma specimens from 10 healthy individuals, 10 patients with pneumonia, 7 patients with lung adenocarcinoma of stages I-II respectively, and 10 patients with lung adenocarcinoma of stages III-IV, then analyze the functions of the differential expression of proteins by bioinformatics...
January 24, 2018: Clinical Respiratory Journal
Bodil Ivarsson, Roger Hesselstrand, Göran Rådegran, Barbro Kjellström
BACKGROUND: Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are rare diseases with a gradual decline in physical health. Adherence to treatment is crucial in these very symptomatic and life threatening diseases. OBJECTIVE: To describe PAH and CTEPH patients experience of their self-reported medication adherence, beliefs about medicines and information about treatment. METHODS: A quantitative, descriptive, national cohort survey that included adult patients from all PAH-centres in Sweden...
January 22, 2018: Clinical Respiratory Journal
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"