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Clinical Respiratory Journal

Sarah Ward, Louise Sewell, Sally Singh
INTRODUCTION: Pulmonary Rehabilitation (PR) is a multidisciplinary programme of care for patients with chronic respiratory disease. The educational component is an integral component and represents a large proportion of a programme. However, it can be difficult to secure regular multidisciplinary input to PR programmes. OBJECTIVES: This service evaluation assessed whether DVD presentations are acceptable to patients and effective as an education medium. METHOD: Two PR groups were compared; one group received education by DVD and the other by spoken talk...
September 17, 2018: Clinical Respiratory Journal
Hongyan Pang, Lei Wang, Jie Liu, Shengfeng Wang, Yuanhua Yang, Ting Yang, Chen Wang
INTRODUCTION: Venous thromboembolism (VTE) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is not rare, which would affect the patient's prognosis. OBJECTIVES: To examine the prevalence, risk factors and clinical characteristics of AECOPD patients with VTE. METHODS: We performed this multi-center, prospective, observational study that involved 16 hospitals in China. Patients admitted to hospital due to AECOPD were consecutively enrolled...
September 12, 2018: Clinical Respiratory Journal
Yake Yao, Hua Zhou, Yihong Shen, Qing Yang, Jian Ye, Yiqi Fu, Guohua Lu, Haiyan Lou, Yunsong Yu, Jianying Zhou
BACKGROUND: The early diagnosis of chronic pulmonary aspergillosis (CPA) remains challenging. Currently, a new quantitative IgM antibody assay that enveloped purified galactomannan extracted from Aspergillus fumigatus as antigen was commercially available in China, but its diagnostic value remains to be established. METHODS: To evaluate the role of this commercial IgM assay for diagnosis of CPA, a multi-center prospective study was performed in 12 hospitals in Zhejiang Province, from January 1 to December 31, 2016...
September 6, 2018: Clinical Respiratory Journal
Erika Cavalheiro Skupien, Tássia Kirchmann Lazzari, Sandra Eugênia Coutinho, Denise Rossato Silva
BACKGROUND: Muscle weakness is part of the wasting syndrome associated with TB. Cytokines are candidates as the initial causative agents of the metabolic changes in TB. The objective of this study is to assess the peripheral and respiratory muscle strength in patients with TB and controls and relate these findings with leptin, IL-6 and TNF-α serum levels. METHODS: Case-control study. Hospitalized patients with pulmonary TB and controls were included. Maximal voluntary handgrip strength (HS), maximal inspiratory pressure (MIP) and maximum expiratory pressure (MEP) were measured...
September 4, 2018: Clinical Respiratory Journal
Yongping Yu, Li Yang, Yuhai Zhang, Liang Dong, Jingwen Xia, Ning Zhu, Xinpeng Han, Liying Fang, Yaqin Chai, Mengjie Niu, Lingli Liu, Xuemin Yang, Shuoyao Qu, Shengqing Li
BACKGROUND: The incidence and risk factors of chronic thromboembolic pulmonary hypertension (CTEPH) in patients with acute pulmonary embolism (PE) have been well reported. However, in real world, patients diagnosed with PE for the first time were usually composed of acute PE, sub-acute PE and chronic PE, and the cumulative incidence and risk factors of CTEPH in this cohort were still unknown. METHODS: A prospective, long-term, follow-up study was conducted to assess the incidence of symptomatic CTEPH in consecutive patients with PE diagnosed for the first time...
August 30, 2018: Clinical Respiratory Journal
Jiajia Wang, Hua Xu, Chuanyong Mu, Cheng Chen, Lingchuan Guo, Liling Chen, Jian-An Huang, Qiang Guo
OBJECTIVES: The prevention strategies for mother-to-fetus/infant transmission of H7N9 virus have not been well understood, and the study on this subject will provide further insights. METHODS: Reverse transcriptase polymerase chain reaction assay was undertaken to detect H7N9 virus in samples from a pregnant women, a postpartum woman, and their fetus/infant. Pathological features of tissues from the dead fetus were evaluated with hematoxylin and eosin staining. Hemagglutination inhibition assay was used to detect virus-specific antibodies...
August 20, 2018: Clinical Respiratory Journal
Xiaoyan Chen, Jinguo Liu, Mengchan Zhu, Bijie Hu, Fengxi Bai, Wenting Jin, Jian Zhou, Cuicui Chen, Yuanlin Song, Jue Pan
BACKGROUND: Progranulin is a pleiotropic glycosylated protein precursor that plays an important role in inflammation. Limited data exist regarding the role of progranulin in the acute exacerbation of chronic obstructive pulmonary disease (AECOPD). OBJECTIVES: The study is to assess the efficiency of progranulin as a circulating biomarker of AECOPD. METHODS: The plasma progranulin levels were measured and compared in patients with AECOPD (n = 52), patients with stable COPD (n = 56) and healthy controls (n = 36)...
August 12, 2018: Clinical Respiratory Journal
Shi Jin, Shoubo Cao, Shanqi Xu, Chunyan Wang, Qingwei Meng, Yan Yu
INTRODUCTION: Numbers of prognostic factors of small cell lung cancer (SCLC) have been demonstrated in previous studies. However, the identification of biomarkers with easy access, convenience and low consumption is of great value in clinics. OBJECTIVES: In order to find such a biomarker, a single institution study with 1156 SCLC patients was retrospectively conducted to assess the prognostic value of prognostic nutritional index (PNI) on SCLC patients treated with platinum-based chemotherapy...
August 3, 2018: Clinical Respiratory Journal
Xue He, Li Wang, Linhao Zhu, Dongya Yuan, Yongjun He, Tianbo Jin
AIMS: The role of inflammatory cytokines in High-altitude pulmonary edema (HAPE) remains unclear. The purpose of this study was to evaluate the role of IL4 and IL6 gene polymorphism in the development of HAPE in Chinese people. METHODS: In the present study, we screened ten polymorphisms of IL4 and IL6 gene in 265 HAPE and 303 healthy volunteers. Genotypes were determined using the Sequenom MassARRAY method. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression...
August 3, 2018: Clinical Respiratory Journal
Baruch Vainshelboim, Genady Dobin, Jonathan Myers, Jose Oliveira, Avraham Unterman, Shimon Izhakian, Mordechai Reuven Kramer
INTRODUCTION: Exertional desaturation is a cardinal manifestation of idiopathic pulmonary fibrosis (IPF) which raises concerns for serious complications OBJECTIVES: To evaluate the safety of clinically significant desaturation (CSD) during exercise and to assess whether abnormal electrocardiographic (ECG) changes are associated with mortality and hospitalizations in patients with IPF. METHODS: Thirty four IPF patients (68±8 years, 35% women) underwent maximal cycle cardiopulmonary exercise testing (CPET) using 12-lead ECG and pulse oximetry (SpO2 ) and were followed up to 40 months...
August 3, 2018: Clinical Respiratory Journal
Haoyang Zhang, Jing Liu, Tianhao Liu, Yu Wang, Weidan Dai
INTRODUCTION: High incidence of respiratory distress syndrome (RDS) was revealed in preterm infants, which acted as one of the main factors that led to infant death. OBJECTIVES: This network meta-analysis (NMA) was performed to rank the efficacy of different therapies in preventing for premature infants. METHODS: PubMed, Embase, Cochrane Library, CINAHL and CNKI were searched. Statistical analysis was performed using STATA statistical software (Version 12...
August 3, 2018: Clinical Respiratory Journal
Omar Abdel-Rahman
BACKGROUND: The purpose of the current study is to investigate the impact of baseline characteristics on the outcomes of extensive-stage small cell lung cancer (SCLC) patients recruited into a clinical trial. METHODS: This is a secondary analysis of the control arm (etoposide/carboplatin arm) of the 'NCT00363415' study which is a phase III study conducted between 2006 and 2007. Univariate analysis of factors affecting overall and progression-free survival (PFS) was conducted through Cox regression analysis [including age, race, gender, Eastern Cooperative Oncology Group performance score, body mass index, Lactate dehydrogenase, number of metastatic sites and brain metastases]...
August 3, 2018: Clinical Respiratory Journal
Chukwuka Eze, Olarn Roengvoraphoj, Nina-Sophie Schmidt-Hegemann, Lukas Käsmann, Maurice Dantes, Farkhad Manapov
The NCCN guidelines recommend early concurrent hyperfractionated accelerated platin-based chemoradiotherapy (CRT) for limited stage small cell lung cancer (LS-SCLC); thoracic irradiation (TRT) starting with the first or second chemotherapy cycle as treatment standard in patients with UICC 8th edition stages I-IIIA-C. However, general adoption of hyperfractionated accelerated TRT in clinical routine remains relatively low. The recently published CONVERT trial demonstrated non-significant survival outcomes in the twice-daily vs...
August 3, 2018: Clinical Respiratory Journal
Auguste Kaceniene, Edvardas Danila, Saulius Cicenas, Giedre Smailyte
No abstract text is available yet for this article.
August 2, 2018: Clinical Respiratory Journal
Tomoyuki Kawada
I read with great interest the article by Akinci et al. The authors examined the association between sleep quality, daytime sleepiness and quality of life in patients with moderate to very severe chronic obstructive pulmonary disease (COPD), stratified by obstructive sleep apnea (OSA).1 Sleep polysomnography, Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale, The Modified Medical Research Council Dyspnea and SF-36 Health Quality Survey were used for the analysis. This article is protected by copyright...
August 2, 2018: Clinical Respiratory Journal
David Drees, Dmitry Tumin, Rebecca Miller, Stephen Kirkby, Tarun Bhalla, Joseph D Tobias, Don Hayes
INTRODUCTION: Chronic opioid use is common after organ transplantation, and has been associated with poor outcomes in transplantation of abdominal organs. However, little is known about possible influences of chronic opioid use on outcomes of lung transplantation (LTx). OBJECTIVES: We assessed whether long-term chronic opioid use influenced clinical outcomes among LTx recipients at our program. METHODS: We retrospectively evaluated chronic opioid use among bilateral LTx recipients ages 12 and older followed at our institution 1-5 years post-transplant...
July 27, 2018: Clinical Respiratory Journal
Şule Gökçe, Zafer Kurugöl, Aslı Suner
INTRODUCTION AND OBJECTIVE: Acute bronchiolitis might be associated with morbidity and mortality in infants. The aim of this study was to evaluate the role of mean platelet volume (MPV) in the prediction of acute bronchiolitis. METHOD: One hundred and eighty four of these infants were diagnosed with acute bronchiolitis and 100 were healthy children. The ability of MPV, C-reactive protein (CRP), white blood cell (WBC) count and lymphocyte values to predict all bronchiolitis group and the control group were examined by receiver operating characteristic (ROC) curve and their respective areas under the curves (AUC) with 95% confidence intervals...
July 25, 2018: Clinical Respiratory Journal
Muhammet Yusuf Tepebaşı, Nilüfer Şahin Calapoğlu, Önder Öztürk, Okan Sancer, Taner Gonca
INTRODUCTION: Obstructive sleep apnea syndrome (OSAS) is a complex, polygenic and multifactorial disease. The relationship between Human Leukocyte Antigen (HLA) polymorphisms and sleep disturbances has been established, but the relationship with HLA alleles has not been fully clarified. In addition, sleep deprivation in OSAS patients can cause changes that affect the components and responses of the immune system. OBJECTIVE: The aim of this study has assessed the effect of HLA-DRB1 alleles on OSAS disease and the changes occurring in immune response cells in Turkish population...
July 17, 2018: Clinical Respiratory Journal
Hiroshi Ishii, Hisako Kushima, Yoshiaki Kinoshita, Masaki Fujita, Kentaro Watanabe
BACKGROUND: Serum KL-6 is known to be a useful biomarker for the diagnosis and assessment of the disease activity in idiopathic pulmonary fibrosis (IPF). However, some patients with untreated IPF present with a serial decline in their serum KL-6 levels, despite showing clinical progression. OBJECTIVES: The aim of the present study was to evaluate the association between the time course of the serum KL-6 levels and the clinical course of patients with untreated IPF...
July 17, 2018: Clinical Respiratory Journal
Elina Levin, Mark Bowling
BACKGROUND/AIMS: The tracheal bronchus is a rare congenital abnormality with incidence reported in a range of 0.1% to 2%. Infrequently, malignancy has been reported as occurring in the tracheal bronchus. In order to ascertain a relationship between malignancy and the tracheal bronchus, we performed a literature review and present a case series. METHODS: We reviewed 21 case reports of malignancy occurring in the tracheal bronchus. CONCLUSION: Although the number of cases is limited, it appears that bronchoscopy is the most frequently utilized diagnostic tool...
July 17, 2018: Clinical Respiratory Journal
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