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Clinical Respiratory Journal

Chun-Hao Tsai, Lin-Yu Laio, Cheng-Li Lin, Wei-Sheng Chung
BACKGROUND AND AIMS: Inhaled corticosteroids (ICSs) are crucial anti-inflammatory medications for chronic airway diseases. Studies investigating the relationship between ICSs and fractures in Asian populations are scant. We investigated whether ICSs increased the risk of low-energy fractures in patients with chronic airway diseases. METHODS: We used the Longitudinal Health Insurance Database to select patients aged 20 years and older with chronic airway diseases (asthma and COPD) between 2000 and 2011 as the base cohort...
November 17, 2017: Clinical Respiratory Journal
Ana Oliveira, Susan Lage, João Rodrigues, Alda Marques
INTRODUCTION: Computerised respiratory Sounds (CRS) are closely related to the movement of air within the tracheobronchial tree, and are promising outcome measures in patients with chronic obstructive pulmonary disease (COPD). However, CRS measurement properties have been poorly tested. OBJECTIVE: To assess the reliability, validity, and the minimal detectable changes (MDC) of CRS in patients with stable COPD. METHODS: Fifty patients (36♂, 67...
November 17, 2017: Clinical Respiratory Journal
Oren Fruchter, Anna Breslavsky, Tatyana Brozgol, Anna Grossman, Kessi Mikhailova, Alexey Bugayov, Kassa Shimelis, Hananya Vaknine, Oleg Sukmanov
INTRODUCTION: The quality of tissue acquisition during Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a major determinant of the diagnostic yield of the procedure. In the tissue button (TB ) technique the retrieved cellular specimen is fixed in ethanol and subsequently scraped from slide using surgical blade into formaldehyde and processed like ordinary tissue biopsy thus potentially increasing its diagnostic value. OBJECTIVES: To retrospectively evaluate the diagnostic yield of a TB technique in patients undergoing EBUS-TBNA for various malignant and benign conditions...
November 10, 2017: Clinical Respiratory Journal
Omar Abdel-Rahman
OBJECTIVES: To assess the potential clinical and biological predictive markers of survival in pretreated advanced NSCLC patients treated with the three PD-(L)1 inhibitors (nivolumab, pembrolizumab, atezolizumab). Data source/ study selection: PubMed database has been searched. The review author extracted relevant information on participant characteristics and study outcomes for this review and assessed risk of bias of the included trials. Data analysis was conducted through RevMan v.5...
November 8, 2017: Clinical Respiratory Journal
Elena Orlandi, Chiara Citterio, Pietro Seghini, Camilla Di Nunzio, Patrizia Mordenti, Luigi Cavanna
BACKGROUND: Patients with severe thrombocytopenia are considered at risk for bleeding during invasive procedures like thoracentesis. The use of ultrasound (US) significantly reduces the rate of pneumothorax from thoracentesis, but there is a lack of data on safety and efficacy of US guidance in reducing bleeding complications in thoracentesis performed on patients with severe thrombocytopenia. METHODS: We retrospectively analyzed the efficacy and safety of thoracentesis in cancer patients with severe thrombocytopenia...
November 8, 2017: Clinical Respiratory Journal
Xin Pu, Man Song, Xiaoyong Huang, Guangfa Zhu, Dong Chen, Huili Gan, Lianjun Huang
OBJECTIVE: To improve our understanding and facilitate early diagnosis of pulmonary artery sarcoma (PAS). METHODS: The clinical and radiological features of 9 histopathologically confirmed PAS patients were retrospectively analyzed. RESULTS: Our PAS cohort consisted of 5 males and 4 females, with insidious presentation, the main symptoms were dyspnea (88.9%), syncope (33.3%), palpitations (22.2%), chest pain (22.2%), hemoptysis (11.1%) and constitutional symptoms, including fever (44...
November 8, 2017: Clinical Respiratory Journal
Jean-Baptiste Stern, Ludovic Fournel, Benjamin Wyplosz, Philippe Girard, Malik AlNakib, Dominique Gossot, Agathe Seguin-Givelet
INTRODUCTION: Post-pneumonectomy empyema (PPE) is the most severe complication of pneumonectomy. Microbiology and its impact on management and prognosis have rarely been reported Methods: We retrospectively reviewed the files of a series of 37 consecutive patients with PPE over a 10-year period with a special focus on microbiology, means used to treat empyema, and prognosis. RESULTS: PPE occurred within 14 days of pneumonectomy in 17 cases (early PPE) and after postoperative day 16 in 20 patients (delayed PPE)...
November 8, 2017: Clinical Respiratory Journal
Sahajal Dhooria, Ravindra Mehta, Arjun Srinivasan, Karan Madan, Inderpaul Singh Sehgal, Vallandramam Pattabhiraman, Pavan Yadav, Mahadevan Sivaramakrishnan, Anant Mohan, Amanjit Bal, Mandeep Garg, Ritesh Agarwal
INTRODUCTION: Most data on transbronchial lung cryobiopsy (TBLC) are from single centers, with little evidence on the outcome of different methods for performing TBLC. OBJECTIVE: To report the diagnostic yield and safety of TBLC with different procedural techniques. METHODS: Retrospective multicenter study of subjects who underwent TBLC for the diagnosis of diffuse parenchymal lung diseases (DPLDs). The procedure was performed using various methods: flexible or rigid bronchoscopy, with or without the use of fluoroscopy or occlusion balloon...
November 4, 2017: Clinical Respiratory Journal
Seyhan Dülger, Önder Akdeniz, Fevzi Solmaz, Özlem Şengören Dikiş, Tekin Yildiz
BACKGROUND AND AIM: Nasal muco-ciliary clearance time (NMCT) can be measured with the saccharine clearance test which is an inexpensive and easy method. The aim of the present study was to compare and evaluate NMCT using the saccharine clearance test in smokers and non-smokers. MATERIALS AND METHODS: Eighty-five patients whose ages ranged from 18 to 65 years were included in the study. Fifty of the patients were smokers (Group 1) while 35 were healthy, non-smoking volunteers (Group 2)...
November 4, 2017: Clinical Respiratory Journal
Rocco Trisolini, Filippo Natali, Marco Ferrari, Vanina Livi, Daniela Paioli, Micaela Romagnoli, Alessandra Cancellieri
INTRODUCTION AND OBJECTIVES: Endosonography has become standard of care in the diagnostic work-up of mediastinal lymphadenopathy and peribronchial lung lesions, but its success rate in some specific settings/conditions may be hampered by limited needle flexibility and size. We report on our initial experience with the 19G Flex needle, characterized by larger size and greater flexibility as compared with the currently available cytology needles. METHODS: Retrospective review of prospectively collected data on the first 13 consecutive patients submitted to endosonography with the 19G Flex needle...
November 4, 2017: Clinical Respiratory Journal
Buket Akinci, Gökşen Kuran Aslan, Esen Kiyan
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is highly associated with Obstructive Sleep Apnea (OSA). Poor sleep quality found related with decreased quality of life in COPD patients but no study assessed this relationship on the basis of nocturnal sleep parameters. OBJECTIVES: The aim of this study is to explore relationships between sleep quality, daytime sleepiness, and quality of life in moderate to very severe COPD patients with and without sleep apnea assessed objectively and compare sleep quality, quality of life and daytime sleepiness in COPD patients with and without sleep apnea...
November 4, 2017: Clinical Respiratory Journal
Hsu-Chao Chang, Chou-Chin Lan, Yao-Kuang Wu, Wen-Lin Su, Mei-Chen Yang
Hypersensitivity pneumonitis is a potentially fatal immunological lung disease caused by occupational or environmental exposure to specific antigens. Here, we report on an obstructive sleep apnea patient whose hypersensitivity pneumonitis was aggravated because of the use of unclean continuous positive airway pressure equipment. This report shows that careful history taking is important when diagnosing hypersensitivity pneumonitis. Sleep specialists should be aware of the risks related to unclean continuous positive airway pressure equipment use, and obstructive sleep apnea patients should be instructed and monitored in the regular cleaning of their equipment...
November 4, 2017: Clinical Respiratory Journal
Bo Ram Yang, Young-Ae Kang, Heo Eun Young, Bo Kyung Koo, Nam-Kyong Choi, Seung-Sik Hwang, Chang-Hoon Lee
OBJECTIVE: There are regional differences in the burden of tuberculosis (TB). Although these differences might be explained by regional differences in the risk factors of TB, whether such risk factors are actually associated with the regional differences in the TB burden remains unclear. This study aimed to investigate the relationship between the risk factors of and regional differences in TB incidence. METHODS: A cohort study applying nationwide claims database in Republic of Korea included patients newly diagnosed with type 2 diabetes mellitus (DM) in 2009...
November 4, 2017: Clinical Respiratory Journal
Yan Liu, Min Zhu, Jing Geng, Chengjun Ban, Shu Zhang, Wenhui Chen, Yanhong Ren, Xuan He, Wang Chen, Huaping Dai
OBJECTIVE: To investigate the incidence and risk factors of lung cancer in patients with idiopathic pulmonary fibrosis (IPF), and to learn the clinical, imaging and pathological features and of lung cancer in IPF. METHODS: The study population included consecutive 268 IPF patients. Of them, 46 patients had pathologically or cytologically proven lung cancer. The demographic, clinical, HRCT, and pathological features in patients with IPF and lung cancer were analyzed and compared with the patients with IPF alone...
November 2, 2017: Clinical Respiratory Journal
Saeid Safiri, Erfan Ayubi
No abstract text is available yet for this article.
October 31, 2017: Clinical Respiratory Journal
Xiaoli Yang, Yongji Yan, Changjiang Xue, Xuqin Du, Qiao Ye
Background Asbestos exposure may cause asbestos-related lung diseases including asbestosis, pleural abnormalities, and malignancies. The role of asbestos exposure in the development of small airway obstruction remains controversial. Anatomic and physiologic small airway abnormalities may develop as part of the pathophysiologic process of asbestosis. We hypothesized that inhalation of asbestos may induce small airway defects in addition to asbestosis and pleural abnormalities. Methods In total, 281 patients with newly diagnosed asbestosis were evaluated...
October 31, 2017: Clinical Respiratory Journal
Abdullah Ozkok, Sercin Ozkok, Mumtaz Takır, Halil İbrahim Yakar, Asiye Kanbay
BACKGROUND AND AIM: Obstructive sleep apnea syndrome (OSAS) is well-known to be associated with high risk for cardiovascular (CV) diseases. Heparanase has been recently shown to be related to increased inflammation and vulnerability of the atherosclerotic plaques. Herein we aimed to investigate the relationships between OSAS, heparanase and endothelial dysfunction. MATERIALS AND METHODS: A total of 120 patients with varying severity of OSAS and 31 controls without OSAS were enrolled...
October 31, 2017: Clinical Respiratory Journal
Ge-Ping Qu, Xiang-Qun Fang, Ya-Ping Xu, Min Shi, Yang Wang, Mei-Liang Gong, Hao-Ming Fang
OBJECTIVE: This study aims to investigate the correlation between α-amylase in tracheal aspirates and risk factors of aspiration, as well as ventilator-associated pneumonia (VAP), in elderly patients undergoing mechanical ventilation; and explore the clinical value of α-amylase for predicting VAP. METHODS: Tracheal aspirates were collected from elderly patients within two weeks after tracheal intubation in mechanical ventilation, and α-amylase was detected. Patients were grouped according to the presence of VAP...
October 31, 2017: Clinical Respiratory Journal
José M Porcel
OBJECTIVES: To summarize the evidence underlying the non-surgical management of patients with complicated parapneumonic effusions (CPPE) or empyemas. DATA SOURCE: All articles published in PubMed according to their relevance with the subject were identified. RESULTS AND CONCLUSIONS: There is a lack of powered randomized controlled studies comparing medical and surgical approaches to CPPE/empyemas in adults. In addition to antibiotics for an unspecified period of time, CPPE/empyemas can initially be treated with a therapeutic thoracentesis (which can be repeated if necessary), the insertion of a small-bore chest catheter under ultrasound guidance, or the administration through the catheter of fibrinolytics alone, saline alone, or fibrinolytics in combination with either saline or deoxyribonuclease...
October 31, 2017: Clinical Respiratory Journal
Yueqin Cao, Changzhou Shao, Yuanlin Song
INTRODUCTION: Early diagnosis of invasive bronchopulmonary aspergillosis (IBPA) is difficult, so the mortality rate is high. OBJECTIVE: To discuss the clinical features of IBPA. METHODS: We retrospectively analyzed the clinical features, imaging findings, laboratory test, diagnosis, and treatment of 115 patients with IBPA diagnosed from October 2004 to June 2013 in Zhongshan Hospital, Fudan University. RESULTS: The main clinical manifestations were cough in 58 patients (50...
October 20, 2017: Clinical Respiratory Journal
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