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Chemistry Central Journal

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https://www.readbyqxmd.com/read/30232633/design-synthesis-and-biological-potential-of-heterocyclic-benzoxazole-scaffolds-as-promising-antimicrobial-and-anticancer-agents
#1
Saloni Kakkar, Sanjiv Kumar, Balasubramanian Narasimhan, Siong Meng Lim, Kalavathy Ramasamy, Vasudevan Mani, Syed Adnan Ali Shah
BACKGROUND: Benzoxazole is the most important class of heterocyclic compound in medicinal chemistry. It has been incorporated in many medicinal compounds making it a versatile heterocyclic compound that possess a wide spectrum of biological activities. RESULTS: The molecular structures of synthesized benzoxazole derivatives were confirmed by physicochemical and spectral means. The synthesized compounds were further evaluated for their in vitro biological potentials i...
September 19, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/30173362/regio-and-stereoselective-synthesis-of-anticancer-spirooxindolopyrrolidine-embedded-piperidone-heterocyclic-hybrids-derived-from-one-pot-cascade-protocol
#2
Natarajan Arumugam, Abdulrahman I Almansour, Raju Suresh Kumar, Dhaifallah M Al-Thamili, Govindasami Periyasami, V S Periasamy, Jegan Athinarayanan, Ali A Alshatwi, S M Mahalingam, J Carlos Menéndez
BACKGROUND: Spiropyrrolidine tethered piperidone heterocyclic hybrids were synthesized with complete regio- and stereoselectively in excellent yield via a tandem three-component 1,3-dipolar cycloaddition and subsequent enamine reaction in [bmim]Br. The synthesized compounds were evaluated for their anticancer activity against FaDu hypopharyngeal tumor cells. FINDINGS: Interestingly, most compounds displayed cytotoxicities similar to the standard anticancer agent bleomycin, with two of them (5a and 5g) being slightly more active than the reference drug...
September 1, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/30123925/augmentation-of-hepatoprotective-potential-of-aegle-marmelos-in-combination-with-piperine-in-carbon-tetrachloride-model-in-wistar-rats
#3
Deepti Rathee, Anjoo Kamboj, Shabir Sidhu
The current study investigated hepatoprotective and antioxidant effects of Aegle marmelos leaves extract. The major constituent present in the extract i.e. rutin was quantified by using HPLC. Further, the study explored hepatoprotective effect of A. marmelos (70% ethanol extract) in combination with piperine. The normal control and carbon tetrachloride (CCl4 ) administered rats were divided into 7 groups. Hepatic damage biomarkers were determined in serum samples and oxidative stress biomarkers (malondialdehyde, reduced glutathione, glutathione reductase, glutathione peroxidase, glutathione-S-transferase, superoxide dismutase and catalase), pro-inflammatory and anti-inflammatory cytokines were determined in liver homogenates...
August 20, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/30116915/polyaniline-palladium-nanohybrids-for-moisture-and-hydrogen-detection
#4
Chanaka Sandaruwan, H M P C K Herath, T S E F Karunarathne, S P Ratnayake, G A J Amaratunga, D P Dissanayake
Palladium nanoparticles display fascinating electronic, optical and catalytic properties, thus they can be used for various applications such as sensor fabrication. Conducting polymers such as polyaniline have also been widely used in sensor technology due to its cost effectiveness, versatility, and ease of synthesis. In this research, attention was given to unify the exceptional properties of these two materials and construct palladium nanoparticle coated polyaniline films to detect hydrogen and moisture. Electrochemical polymerization of aniline was carried out on gold sputtered epoxy resin boards...
August 16, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/30101384/benzoxazole-derivatives-design-synthesis-and-biological-evaluation
#5
Saloni Kakkar, Sumit Tahlan, Siong Meng Lim, Kalavathy Ramasamy, Vasudevan Mani, Syed Adnan Ali Shah, Balasubramanian Narasimhan
BACKGROUND: A new series of benzoxazole analogues was synthesized and checked for their in vitro antibacterial, antifungal and anticancer activities. RESULTS AND DISCUSSION: The synthesized benzoxazole compounds were confirmed by IR, 1 H/13 C-NMR, mass and screened for their in vitro antimicrobial activity against Gram-positive bacterium: Bacillus subtilis, four Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Salmonella typhi and two fungal strains: Candida albicans and Aspergillus niger using tube dilution technique and minimum inhibitory concentration (MIC) was noted in µM and compared to ofloxacin and fluconazole...
August 12, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/30097852/production-of-single-cell-oil-from-cane-molasses-by-rhodotorula-kratochvilovae-syn-rhodosporidium-kratochvilovae-sy89-as-a-biodiesel-feedstock
#6
Tamene Milkessa Jiru, Laurinda Steyn, Carolina Pohl, Dawit Abate
BACKGROUND: Single cell oil has long been considered an alternative to conventional oil sources. The oil produced can also be used as a feedstock for biodiesel production. Oleaginous yeasts have relatively high growth and lipid production rates, can utilize a wide variety of cheap agro-industrial wastes such as molasses, and can accumulate lipids above 20% of their biomass when they are grown in a bioreactor under conditions of controlled excess carbon and nitrogen limitation. RESULTS: In this study, Rhodotorula kratochvilovae (syn, Rhodosporidium kratochvilovae) SY89 was cultivated in a nitrogen-limited medium containing cane molasses as a carbon source...
August 10, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/30094628/hapke-based-computational-method-to-enable-unmixing-of-hyperspectral-data-of-common-salts
#7
Fares M Howari, Gheorge Acbas, Yousef Nazzal, Fatima AlAydaroos
Environmental scientists are currently assessing the ability of hyper-spectral remote sensing to detect, identify, and analyze natural components, including minerals, rocks, vegetation and soil. This paper discusses the use of a nonlinear reflectance model to distinguish multicomponent particulate mixtures. Analysis of the data presented in this paper shows that, although the identity of the components can often be found from diagnostic wavelengths of absorption bands, the quantitative abundance determination requires knowledge of the complex refractive indices and average particle scattering albedo, phase function and size...
August 9, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/30088167/free-radicals-and-ultrafine-particulate-emissions-from-the-co-pyrolysis-of-croton-megalocarpus-biodiesel-and-fossil-diesel
#8
Joshua K Kibet, Bornes C Mosonik, Vincent O Nyamori, Silas M Ngari
BACKGROUND: The atmosphere has become a major transport corridor for free radicals and particulate matter from combustion events. The motivation behind this study was to determine the nature of particulate emissions and surface bound radicals formed during the thermal degradation of diesel blends in order to assess the health and environmental hazards of binary transport fuels. METHODOLOGY: Accordingly, this contribution explored the interactions that occur when Croton megalocarpus biodiesel and fossil diesel in the ratio of 1:1 by weight were co-pyrolyzed in a quartz reactor at a residence time of 0...
August 7, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/30078060/folic-acid-minerals-amino-acids-fatty-acids-and-volatile-compounds-of-green-and-red-lentils-folic-acid-content-optimization-in-wheat-lentils-composite-flours
#9
Adriana Paucean, Ovidiu P Moldovan, Vlad Mureșan, Sonia A Socaci, Francisc V Dulf, Ersilia Alexa, Simona M Man, Andruţa E Mureșan, Sevastița Muste
The advanced biochemical characterisation of green, red lentil and wheat flours was performed by assessing their folic acid content as well as individual minerals, amino acids, fatty acids and volatile compounds. Moreover, a nutritionally improved wheat-lentil composite flour, with a content of 133.33 μg of folic acid/100 g, was proposed in order to assure the folic acid daily intake (200 μg) for an adult person. The wheat and lentil flours percentages used for the composite were calculated by using the equations for total material balance and folic acid content material balance...
August 4, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/30043329/immobilization-of-cesium-from-aqueous-solution-using-nanoparticles-of-synthetic-calcium-phosphates
#10
Oksana Livitska, Nataliia Strutynska, Kateryna Loza, Oleg Prymak, Yuriy Prylutskyy, Olha Livitska, Matthias Epple, Nikolai Slobodyanik
The particularities of cesium incorporation into synthetic calcium phosphates with either apatite or whitlockite-type structures were investigated using the sorption process from aqueous solution and further heating to 700 °C. The nanoparticles for sorption were prepared by wet precipitation from aqueous solutions at a fixed molar ratio of Ca/P = 1.67 and two different ratios of CO3 2- /PO4 3- (0 or 1). The obtained substituted calcium phosphates and corresponding samples after the sorption of cesium from solutions with different molar concentrations (c(Cs+ ) = 0...
July 24, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/30043180/ethyl-carbamate-in-swedish-and-american-smokeless-tobacco-products-and-some-factors-affecting-its-concentration
#11
K McAdam, C Vas, H Kimpton, A Faizi, C Liu, A Porter, T Synnerdahl, P Karlsson, B Rodu
BACKGROUND: We are interested in comparing the levels of harmful or potentially harmful constituents in Swedish and American smokeless tobacco products (STPs). We report here the concentrations of the IARC Group 2 A (probable human) carcinogen ethyl carbamate (EC) in seventy commercial STPs from the US and Sweden, representing 80-90% of the market share of the major STP categories in these countries. We also examine the effects of various additives, processing and storage conditions on EC concentrations in experimental snus samples...
July 24, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/30027362/simultaneous-determination-of-five-azadirachtins-in-the-seed-and-leaf-extracts-of-azadirachta-indica-by-automated-online-solid-phase-extraction-coupled-with-lc-q-tof-ms
#12
Li Song, Jin Wang, Quan Gao, Xiaojiang Ma, Yuwei Wang, Yaoyao Zhang, Hang Xun, Xi Yao, Feng Tang
Neem (Azadirachta indica) extract is well-known as a natural pesticide for the control of agricultural pests. Azadirachtin A and its structural analogues are considered as active compounds. However, the amounts of azadirachtins varies in neem extracts, providing a variety of insecticidal activities. In this study, a novel method of automated online solid-phase extraction coupled with liquid chromatography/quadrupole-time-of-flight mass spectrometry (SPE-LC-Q-TOF-MS) was developed and validated for simultaneous quantification of five azadirachtins (azadirachtins A, B, D, H and I) in seed and leaf extracts of A...
July 19, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/30019193/facile-synthesis-of-n-4-bromophenyl-1-3-bromothiophen-2-yl-methanimine-derivatives-via-suzuki-cross-coupling-reaction-their-characterization-and-dft-studies
#13
Komal Rizwan, Nasir Rasool, Ravya Rehman, Tariq Mahmood, Khurshid Ayub, Tahir Rasheed, Gulraiz Ahmad, Ayesha Malik, Shakeel Ahmad Khan, Muhammad Nadeem Akhtar, Noorjahan Banu Alitheen, Muhammad Nazirul Mubin Aziz
A variety of imine derivatives have been synthesized via Suzuki cross coupling of N-(4-bromophenyl)-1-(3-bromothiophen-2-yl)methanimine with various arylboronic acids in moderate to good yields (58-72%). A wide range of electron donating and withdrawing functional groups were well tolerated in reaction conditions. To explore the structural properties, Density functional theory (DFT) investigations on all synthesized molecules (3a-3i) were performed. Conceptual DFT reactivity descriptors and molecular electrostatic potential analyses were performed by using B3LYP/6-31G(d,p) method to explore the reactivity and reacting sites of all derivatives (3a-3i)...
July 17, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/30019094/design-and-synthesis-of-novel-3-thiophen-2-yl-1-5-dihydro-2h-pyrrol-2-one-derivatives-bearing-a-hydrazone-moiety-as-potential-fungicides
#14
Xiaobin Wang, Zhengjiao Ren, Mengqi Wang, Min Chen, Aiming Lu, Weijie Si, Chunlong Yang
BACKGROUND: Tetramic acid, thiophene and hydrazone derivatives were found to exhibit favorable antifungal activity. Aiming to discover novel template molecules with potent antifungal activity, a series of novel 3-(thiophen-2-yl)-1,5-dihydro-2H-pyrrol-2-one derivatives containing a hydrazone group were designed, synthesized, and evaluated for their antifungal activity. RESULTS: The structures of 3-(thiophen-2-yl)-1,5-dihydro-2H-pyrrol-2-one derivatives bearing a hydrazone group were confirmed by FT-IR, 1 H NMR, 13 C NMR, 1 H-1 H NOESY, EI-MS and elemental analysis...
July 17, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/30003449/inhibitory-effects-against-%C3%AE-glucosidase-and-%C3%AE-amylase-of-the-flavonoids-rich-extract-from-scutellaria-baicalensis-shoots-and-interpretation-of-structure-activity-relationship-of-its-eight-flavonoids-by-a-refined-assign-score-method
#15
Ke Li, Fan Yao, Qiang Xue, Hang Fan, Lingguang Yang, Xiang Li, Liwei Sun, Yujun Liu
A flavonoids-rich extract of Scutellaria baicalensis shoots and its eight high content flavonoids were investigated for their inhibitory effects against α-glucosidase and α-amylase. Results show that abilities of the extract in inhibiting the two enzymes were obviously higher than those of acarbose. Moreover, inhibitory abilities of all the eight individual flavonoids against the two enzymes show exactly a same order (i.e., apigenin > baicalein > scutellarin > chrysin > apigenin-7-O-glucuronide > baicalin > chrysin-7-O-glucuronide > isocarthamidin-7-O-glucuronide), and their structure-activity relationship could be well-interpretated by the refined assign-score method...
July 12, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/29995251/removal-of-malachite-green-from-aqueous-solution-using-pulverized-teak-leaf-litter-equilibrium-kinetic-and-thermodynamic-studies
#16
Emmanuel O Oyelude, Johannes A M Awudza, Sylvester K Twumasi
The removal of malachite green (MG) from aqueous solution using teak leaf litter powder (TLLP) was investigated. The process was influenced by initial concentration, pH and temperature of dye solution as well as TLLP dosage. Optimum removal of MG per gram of TLLP occurred at 2 g/L and at pH 6-8. Dubinin-Radushkevich and Freundlich isotherm models fit the batch adsorption data better than Langmuir isotherm. The monolayer capacity of TLLP was 333.33 mg/g at 293-313 K. The mean free energy of 7.07 kJ/mol implied physical adsorption...
July 11, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/29987444/preparation-of-polyetherimide-membrane-from-non-toxic-solvents-for-the-separation-of-hydrogen-from-methane
#17
Yousef Alqaheem, Abdulaziz Alomair, Abdulwahab Alhendi, Sharifah Alkandari, Nusrat Tanoli, Nourah Alnajdi, Andrés Quesada-Peréz
Polymeric membranes are usually prepared from solvents like n-methylpyrrolidone (NMP) because of the strong dissolving power and high boiling point. Yet, the solvent is costly, toxic and has environmental issues. In this work, nontoxic solvents such as methyl L-lactate, ethyl lactate, propylene carbonate, tributyl o-acetylcitrate, tributyl citrate, triethyl phosphate, and γ-butyrolactone (GBL) were introduced during membrane preparation. It was found that all the solvents were unable to dissolve polyetherimide except GBL...
July 10, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/29987505/synthesis-and-properties-of-novel-styrene-acrylonitrile-polypropylene-blends-with-enhanced-toughness
#18
Yi-Jun Liao, Xiao-Li Wu, Lin Zhu, Tao Yi
BACKGROUND: Although polypropylene (PP) has been widely used, its brittleness restricts even further applications. METHODS: In this study, we have used a melt blending process to synthesize styrene acrylonitrile (SAN)/PP blends containing 0, 5, 10, 15 and 20 wt% SAN. The effects of adding various amount of SAN on the blends characteristics, mechanical properties, thermal behavior and morphology were investigated. RESULTS: The results demonstrated that SAN had no obviously effect on crystal form but reduced the crystallinity of PP and increased the viscosity...
July 9, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/29987451/wastewaters-treatment-containing-phenol-and-ammonium-using-aerobic-submerged-membrane-bioreactor
#19
Mashallah Rezakazemi, Mohsen Maghami, Toraj Mohammadi
Phenolic wastewater was treated using anaerobic submerged membrane bioreactor (ASMBR). Effect of different solids retention times on MBR performance was studied. Various ratios of carbon to nitrogen were used in the synthetic wastewaters. During the operation, phenol concentration of feed was changed from 100 to 1000 mg L-1 . Phenol concentration was increased stepwise over the first 30 days and kept constant at 1000 mg L-1 , thereafter. For the first 100 days, a chemical oxygen demand (COD) to N ratio of 100:5...
July 9, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/29961226/determination-of-carbamazepine-in-urine-and-water-samples-using-amino-functionalized-metal-organic-framework-as-sorbent
#20
Mohammad Reza Rezaei Kahkha, Ali Reza Oveisi, Massoud Kaykhaii, Batool Rezaei Kahkha
A stable and porous amino-functionalized zirconium-based metal organic framework (Zr-MOF-NH2 ) containing missing linker defects was prepared and fully characterized by FTIR, scanning electron microscopy, powder X-ray diffraction, and BET surface area measurement. The Zr-MOF-NH2 was then applied as an adsorbent in pipette-tip solid phase extraction (PT-SPE) of carbamazepine. Important parameters affecting extraction efficiency such as pH, sample volume, type and volume of eluent, amount of adsorbent, and number of aspirating/dispensing cycles for sample solution and eluent solvent were investigated and optimized...
June 30, 2018: Chemistry Central Journal
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