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Chemistry Central Journal

Sahar Marghzari, Mojtaba Sasani, Massoud Kaykhaii, Mona Sargazi, Mohammad Hashemi
The purpose of this study was to investigate the feasibility of simultaneous optimization and removal of dyes, Malachite green (MG), Rhodamine B (RhB) and Cresol Red (CR) from aqueous solutions by using Sistan sand as an extremely low cost adsorbent. Factors affecting adsorption of the analytes on the sorbent were investigated experimentally and by using Taguchi and Plackett-Burman experimental design methods. In most cases, the results of these two models were in agreement with each other and with experimental data obtained...
November 16, 2018: Chemistry Central Journal
Mingsha Shao, Xinfa Bai, Xuan Ma, Ning Yan, Lei Yao
BACKGROUND: Tubulysins family is a kind of natural compound with potent, antitumor activity. To simplify the synthesis route and find new antitumor compounds is becoming a hotspot of research recent years. RESULTS: Starting from 3-nitrobenzoic acid, after 7 steps transformations, 12 new tubulysin analogues were synthesized by the conformational restraint and bioisostere principle. These structures are featuring 3-substituted analine moieties. All these compounds are new compounds, and the structures were characterized by 1 H NMR, 13 C NMR, and HRMS...
November 15, 2018: Chemistry Central Journal
Hamid Beyzaei, Mahboubeh Kamali Deljoo, Reza Aryan, Behzad Ghasemi, Mohammad Mehdi Zahedi, Mohammadreza Moghaddam-Manesh
BACKGROUND: Design and synthesis of new inhibitor agents to deal with pathogenic microorganisms is expanding. In this project, an efficient, environmentally friendly, economical, rapid and mild procedure was developed for the synthesis of novel functionalized isoxazole derivatives as antimicrobial potentials. METHODS: Multicomponent reaction between malononitrile (1), hydroxylamine hydrochloride (2) and different aryl or heteroaryl aldehydes 3a-i afforded novel 5-amino-isoxazole-4-carbonitriles 4a-i in good product yields and short reaction times...
November 15, 2018: Chemistry Central Journal
Sebastião G Silva, Pablo Luis B Figueiredo, Lidiane D Nascimento, Wanessa A da Costa, José Guilherme S Maia, Eloisa Helena A Andrade
BACKGROUND: The oil and extracts of Lippia thymoides have been used for various medicinal and food applications. Entrepreneurs in the Amazon have been considering the economic exploitation of this plant. The present study evaluated the influence of the seasonal and circadian rhythm on the yield and composition of the essential oil of leaves and thin branches of a Lippia thymoides specimen cultivated in Abaetetuba, State of Pará, Brazil. The constituents of the oils were identified by GC and GC-MS and with the application of multivariate analysis: Principal Component Analysis (PCA) and Hierarchical Cluster Analysis (HCA)...
November 12, 2018: Chemistry Central Journal
Priyanka Dhiman, Neelam Malik, Anurag Khatkar
BACKGROUND: Monoamine oxidase has been implicated in numerous neurological disorders. Although synthetic monoamine oxidase inhibitors (MAOI) have emerged with many side effects, the aspiration of natural based MAOI has greatly increased. As they exhibit fewer side effects and food interaction along with improved neuropharmacological profile. RESULTS: The in silico design of the caffeic acid derivatives led potent MAO inhibitors with remarkable antioxidant activity...
November 9, 2018: Chemistry Central Journal
Fawzia Faleh Al-Blewi, Meshal A Almehmadi, Mohamed Reda Aouad, Sanaa K Bardaweel, Pramod K Sahu, Mouslim Messali, Nadjet Rezki, El Sayed H El Ashry
BACKGROUND: Nitrogen heterocyclic rings and sulfonamides have attracted attention of several researchers. RESULTS: A series of regioselective imidazole-based mono- and bis-1,4-disubstituted-1,2,3-triazole-sulfonamide conjugates 4a-f and 6a-f were designed and synthesized. The first step in the synthesis was a regioselective propargylation in the presence of the appropriate basic catalyst (Et3 N and/or K2 CO3 ) to afford the corresponding mono-2 and bis-propargylated imidazoles 5...
November 1, 2018: Chemistry Central Journal
Xiang Zhu, Linhua Yu, Min Zhang, Zhihong Xu, Zongli Yao, Qinglai Wu, Xiaoying Du, Junkai Li
We prepared 16 novel hydroxybenzoic acid ester conjugates of phenazine-1-carboxylic acid (PCA) and investigated their biological activity. Most of the synthesized conjugates displayed some level of fungicidal activities in vitro against five phytopathogenic fungi. Nine conjugates 5b, 5c, 5d, 5e, 5h, 5i, 5m, 5n and 5o (EC50 between 3.2 μg/mL and 14.1 μg/mL) were more active than PCA (EC50 18.6 μg/mL) against Rhizoctonia solani. Especially conjugate 5c showed the higher fungicidal activity against Rhizoctonia solani which is 6...
November 1, 2018: Chemistry Central Journal
Min Zhang, Junwen Wu, Juanjuan Han, Hongmei Shu, Kehai Liu
Dendrobium officinale stem is rich in polysaccharides, which play a great role in the medicinal effects of this plant. However, little was known about the polysaccharides from Dendrobium officinale leaves. Two kinds of polysaccharides in the leaves, DLP-1 and DLP-2, were obtained by hot water extraction, alcohol sedimentation and chromatographic separation (DEAE-52 cellulose column and Sephadex G-100 column). The average molecular weights were determined as 28,342 Da and 41,143 Da, respectively. Monosaccharide compositions were analyzed using gas chromatography-mass spectrometer...
October 31, 2018: Chemistry Central Journal
Hossein Mohammad Zaheri, Shahrzad Javanshir, Behnaz Hemmati, Zahra Dolatkhah, Maryam Fardpour
Magnetically recoverable polysaccharide-based metallic nanoparticles Carrageenan moss/Fe3 O4 (Fe3 O4 @CM) was tested for the synthesis of Pyrimidinone derivatives via Biginelli reaction under reflux conditions in Water. Interestingly, Fe3 O4 @CM prepared from unmodified Irish moss showed remarkable catalytic activity and recyclability. Low catalyst loading, simple reaction procedure, and using a green catalyst from a natural source are the important merits of this protocol.
October 27, 2018: Chemistry Central Journal
Deepika Sharma, Sanjiv Kumar, Balasubramanian Narasimhan
BACKGROUND: Cancer is at present one of the leading causes of death in the world. It accounts for 13% of deaths occurred worldwide and is continuously rising, with an estimated million of deaths up to 2030. Due to poor availability of prevention, diagnosis and treatment of breast cancer, the rate of mortality is at alarming level globally. In women, hormone-dependent estrogen receptor positive (ER+) breast cancer making up approximately 75% of all breast cancers. Hence, it has drawn the extensive attention of researchers towards the development of effective drugs for the treatment of hormone-dependent breast cancer...
October 25, 2018: Chemistry Central Journal
Sanjiv Kumar, Jagbir Singh, Balasubramanian Narasimhan, Syed Adnan Ali Shah, Siong Meng Lim, Kalavathy Ramasamy, Vasudevan Mani
BACKGROUND: Pyrimidine is an important pharmacophore in the field of medicinal chemistry and exhibit a broad spectrum of biological potentials. A study was carried out to identify the target protein of potent bis-pyrimidine derivatives using reverse docking program. PharmMapper, a robust online tool was used for identifying the target proteins based on reverse pharmacophore mapping. The murine macrophage (RAW 264.7) and human embryonic kidney (HEK-293) cancer cell line used for selectivity and safety study...
October 22, 2018: Chemistry Central Journal
Selvaraj Arokiyaraj, Rajaraman Bharanidharan, Paul Agastian, Hakdong Shin
BACKGROUND: In the present study, hexane: methanol (50:50) leaf extract of Marisela minuta has been evaluated for its chemical composition, antioxidant effect and the antimicrobial mechanism of action against food borne pathogenic bacteria. RESULTS: The phytochemical evaluation of extract by GC/MS revealed the major abundance of benzoic acid-4-ethoxyethyl ester (43.39%) and farnesol acetate (18.42%). The extract exhibited potential antioxidant and free radical scavenging properties with promising antibacterial activities against the test pathogens with Pseudomonas aeruginosa being the most susceptible with maximum inhibition zone (17 mm) and IC50 value of 125 µg, respectively...
October 20, 2018: Chemistry Central Journal
Jinfeng Zhang, Yan Gao, Jiyao Zhang, Jianshe Zhao, Hanxi Shen
A series of TiO2 -V2 O5 -MCM-41 molecular sieve catalysts were prepared by the impregnation method. The prepared catalysts were characterized by different techniques including X-ray diffraction, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and N2 adsorption-desorption. These catalysts were applied in the catalytic synthesis of diphenyl carbonate (DPC) by the transesterification of dimethyl carbonate (DMC) with phenol. The synthesis results indicated that the catalysts possessed the high specific surface area and large pore volume and included titanium with four ligands...
October 20, 2018: Chemistry Central Journal
Shangping Xing, Xiaofeng Zhang, Hannu Ke, Ji Lin, Yuechun Huang, Gang Wei
The original version of the article [1] contained a mistake. The Figure legends are right, but the pictures in Figs. 3 and 4 are contrary. The corrected figures are given below.
October 11, 2018: Chemistry Central Journal
Noroska Gabriela Salazar Mogollón, Guilherme Lionello Alexandrino, José Rafael de Almeida, Zulay Niño-Ruiz, José Gregorio Peña-Delgado, Roldán Torres-Gutiérrez, Fabio Augusto
The current methodology used in quality control of Ecuadorian beverages such as Pájaro azúl, Puro and Pata de vaca is carried out by using conventional gas chromatography; however, it does not allow the fingerprinting of these Ecuadorian spirit beverages and their possible cases of adulteration. In order to overcome this drawback, comprehensive two-dimensional gas chromatography-mass spectrometry (GC × GC-MS) was combined with multivariate data analysis, revealing that compounds like citronellal, citronellol, geraniol, methyl anthranilate, (-)-trans-α-bergamotene, (-)-cis-α-bergamotene and D-limonene can be considered key elements for pattern recognition of these traditional beverages and product adulteration cases...
October 11, 2018: Chemistry Central Journal
Sraa Abu-Melha
N-(pyridin-2-yl)hydrazinecarbothioamide has been synthesized and characterized by single-crystal X-ray and spectroscopic techniques. Furthermore, its geometry optimization, calculated vibrational frequencies, non-linear optical properties, electrostatic potential and average local ionization energy properties of molecular surface were being evaluated using Jaguar program in the Schrödinger's set on the basis of the density functional concept to pretend the molecular geometry and predict properties of molecule performed by the hybrid density functional routine B3LYP...
September 29, 2018: Chemistry Central Journal
Shangping Xing, Xiaofeng Zhang, Hannu Ke, Ji Lin, Yuechun Huang, Gang Wei
BACKGROUND: Dendrobium officinale as a precious traditional Chinese herb is widely used in medicines and health supplements. Thus the extraction, purification and biological activities of polysaccharides from the stem of Dendrobium officinale have significant meaning on theory and application value. METHODS: The crude Dendrobium officinale polysaccharide (DOP) was obtained by hot water extraction- ethanol precipitation method, and four new polysaccharide fractions (DOP-40, DOP-50, DOP-60, and DOP-70) were further obtained from the crude DOP by fractional precipitation with ethanol method, then four fractions were further purified by Toyopearl-H65F gel resin...
September 25, 2018: Chemistry Central Journal
Mohamed W Attwa, Adnan A Kadi, Hany W Darwish, Sawsan M Amer, Nasser S Al-Shakliah
Vandetanib (Caprelsa tablets, VNT) is an orally inhibitor of vascular endothelial growth factor receptor 2. The current research reports the characterization and identification of in vitro, in vivo and reactive intermediates of VNT. In vitro metabolites of VNT were performed by incubation with rat liver microsomes (RLMs). Extraction of vandetanib and its in vitro metabolites from the incubation mixtures were done by protein precipitation. In vivo metabolism was done by giving one oral dose of vandetanib (30...
September 24, 2018: Chemistry Central Journal
Francesca Becherini, Caterina Durante, Elsa Bourguignon, Mario Li Vigni, Vincent Detalle, Adriana Bernardi, Patrizia Tomasin
BACKGROUND AND METHODS: Wall paintings and architectural surfaces in outdoor environments are exposed to several physical, chemical and biological agents, hence they are often treated with different products to prevent or slow down their deterioration. Among the factors that have to be taken into account in the selection of the most suitable treatment for decorated surfaces, the aesthetic compatibility with the substrate is of great importance in the cultural heritage field; minimizing colour variation after treatment application is a crucial issue in particular for painted surfaces...
September 21, 2018: Chemistry Central Journal
Cyrille Ngoufack Tagousop, Jean-de-Dieu Tamokou, Irene Chinda Kengne, David Ngnokam, Laurence Voutquenne-Nazabadioko
BACKGROUND: Resistance of bacteria and fungi to antibiotics is one of the biggest problems that faces public health. The present work was designated to evaluate the antimicrobial activities of saponins from Melanthera elliptica and their synergistic effects with standard antibiotics against pathogenic phenotypes. The plant extract was prepared by maceration in methanol. The methanol extract was partitioned into ethyl acetate and n-butanol extracts. Column chromatography of the n-butanol extract followed by purification of different fractions led to the isolation of four saponins...
September 20, 2018: Chemistry Central Journal
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