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Chemistry Central Journal

Wen Liang, Li Xu, Zhiwei Sui, Yan Li, Lanying Li, Yanli Wen, Chunhua Li, Shuzhen Ren, Gang Liu
BACKGROUND: The accuracy and metrology traceability of DNA quantification is becoming a critical theme in many fields, including diagnosis, forensic analysis, microorganism detection etc. Thus the research of DNA reference materials (RMs) and consistency of DNA quantification methods has attracted considerable research interest. RESULTS: In this work, we developed 3 plasmid candidate RMs, containing 3 target genes of Escherichia coli O157:H7 (E. coli O157:H7) and other Shiga toxin-producing Escherichia coli (STEC): stx1, stx2, and fliC (h7) respectively...
2016: Chemistry Central Journal
Marie-Laine Roy, Christian Gagnon, Jonathan Gagnon
BACKGROUND: Nanomaterials are widely used in industry for their specific properties. Silver nanoparticles (Ag NPs) are largely used in several consumer products notably for their antibacterial properties and will likely be found in wastewater, then in the receiving environment. The development of a product capable to sequestrate those released contaminants is needed. Under environmental conditions, the biopolymer chitosan can generally coordinate the cationic metals. Ag NPs present unique properties due to their high surface/mass ratio which are promising for their sequestration...
2016: Chemistry Central Journal
Hermia N Ikome, Fidele Ntie-Kang, Moses N Ngemenya, Zhude Tu, Robert H Mach, Simon M N Efange
BACKGROUND: Sigma (σ) receptors are membrane-bound proteins characterised by an unusual promiscuous ability to bind a wide variety of drugs and their high affinity for typical neuroleptic drugs, such as haloperidol, and their potential as alternative targets for antipsychotic agents. Sigma receptors display diverse biological activities and represent potential fruitful targets for therapeutic development in combating many human diseases. Therefore, they present an interesting avenue for further exploration...
2016: Chemistry Central Journal
Iltaf Shah, James Barker, Declan P Naughton, Stephen J Barton, Syed Salman Ashraf
BACKGROUND: A gas chromatography mass spectrometry (GCMS) method for the determination of diclofenac in human plasma has been developed and validated. RESULTS: This method utilizes hexane which is a relatively less toxic extraction solvent compared to heptane and benzene. In addition, phosphoric acid and acetone were added to the samples as deproteination agents, which increased the recovery of diclofenac. These revised processes allow clean extraction and near-quantitative recovery of analyte (approx...
2016: Chemistry Central Journal
Fang Liu, Wei Cao, Chao Deng, Zhaoquan Wu, Guangyao Zeng, Yingjun Zhou
BACKGROUND: Influenza is historically an ancient disease that causes annual epidemics and, at irregular intervals, pandemics. At present, the first-line drugs (oseltamivir and zanamivir) don't seem to be optimistic due to the spontaneously arising and spreading of oseltamivir resistance among influenza virus. Pogostemon cablin (Blanco) Benth. (P. cablin) is an important traditional Chinese medicine herb that has been widely used for treatment on common cold, nausea and fever. In our previous study, we have identified an extract derived from P...
2016: Chemistry Central Journal
Jin-Xia Mu, Yan-Xia Shi, Hong-Ke Wu, Zhao-Hui Sun, Ming-Yan Yang, Xing-Hai Liu, Bao-Ju Li
BACKGROUND: The increasing prevalence of multi-drug resistant fungal infections has encouraged the search for new antifungal agents. Hydrazone derivatives always exhibited diversity activities, including antifungal, anti-inflammatory, anti-oxidation, anti-cancer activity. Regarding the heterocyclic moiety, 1,2,4-triazolo[4,3-a]pyridine derivatives also display broad activities, such as antifungal activity, anticonvulsant activity, herbicidal activity, antimicrobial activity and anticancer activity...
2016: Chemistry Central Journal
Neha Sharma, Vikram Bhardwaj, Samar Singh, Sheikh Abid Ali, D K Gupta, Satya Paul, Naresh K Satti, Suresh Chandra, Mahendra K Verma
BACKGROUND: Boswellia serrata, also known as Indian frankincense is a commercially important medicinal plant which has been used for hundreds of years as an Ayurvedic medicine for the attempted treatment of arthritis. It contains naturally occurring triterpenoic acids, called as boswellic acids (BA's). RESULTS: A highly reproducible High performance liquid chromatography-ultraviolet diode array detection (HPLC-UV-DAD) method was developed for the simultaneous determination and quantitative analysis of eight major triterpenoic acids in Boswellia serrata gum resin obtained by different extraction techniques...
2016: Chemistry Central Journal
Linh My Thi Lam, Mai Thanh Thi Nguyen, Hai Xuan Nguyen, Phu Hoang Dang, Nhan Trung Nguyen, Hung Manh Tran, Hoa Thi Nguyen, Nui Minh Nguyen, Byung Sun Min, Jeong Ah Kim, Jae Sue Choi, Mao Van Can
BACKGROUND: Alzheimer's disease (AD) is the most common cause of dementia among the elderly and is characterized by loss of memory and other cognitive functions. An increase in AChE (a key enzyme in the cholinergic nervous system) levels around β-amyloid plaques and neurofibrillary tangles is a common feature of AD neuropathology. Amnesic effects of scopolamine (acetylcholine receptor antagonist) can be investigated in various behavioral tests such as Morris water maze, object recognition, Y-maze, and passive avoidance...
2016: Chemistry Central Journal
Tingjing Zhang, Xinyuan Wei, Zhuang Miao, Hamada Hassan, Yunbo Song, Mingtao Fan
BACKGROUND: Synthetic antioxidants and antimicrobials are losing ground to their natural counterparts and therefore, the food industry has motivated to seek other natural alternatives. Apple pomace, a by-product in the processing of apples, is rich in polyphenols, and plant polyphenols have been used as food additives owing to their strong antioxidant and antimicrobial properties. The goal of this study was to screen the individual polyphenols with antioxidant and antimicrobial activities from the extracts (methanol, ethanol, acetone, ethyl acetate, and chloroform) of Golden Delicious pomace...
2016: Chemistry Central Journal
Chao Qiu, Li-Na Gao, Kuo Yan, Yuan-Lu Cui, Ye Zhang
BACKGROUND: Evodiamine has gained wide interests recently because of its antitumor activities. However, a superior bioavailability is required to achieve better efficacy due to its poor water solubility. The aim of this study was to enhance the evodiamine's aqueous solubility by preparing evodiamine/hydroxypropyl-β-cyclodextrin (EVO/HP-β-CD) inclusion complex, which is incorporated evodiamine into HP-β-CD, and compare the antitumor activities before and after inclusion with HP-β-CD in human hepatoma HepG2 cells...
2016: Chemistry Central Journal
Hai Xuan Nguyen, Tri Cong Le, Truong Nhat Van Do, Tho Huu Le, Nhan Trung Nguyen, Mai Thanh Thi Nguyen
BACKGROUND: Mangifera mekongensis (Anacardiaceae) is cultivated for its edible fruit and has been used in traditional Vietnamese medicine for its anti-aging properties and for treating diabetes, vermifuge, and dysentery. As part of a search for biologically active compounds with reduction of the rate of glucose absorption, a screening has been initiated to evaluate natural product extracts for the inhibition of enzyme α-glucosidase. A n-hexane extract of the bark of M. mekongensis showed strong α-glucosidase inhibitory activity with IC50 value of 1...
2016: Chemistry Central Journal
W K O V Weeratunge, B G K Perera
BACKGROUND: Astaxanthin is a xanthophyll carotenoid, which exhibits many important biological activities including a high degree of antioxidant capacity (AOC) and antibacterial activity, hence has a significant applicability in food, pharmaceutical and cosmetic industries. An attempt was made towards optimization of astaxanthin extraction conditions using three different extraction conditions and a solvent series, from uncooked, cooked and acid-treated shrimp waste, which is a readily available and cheap source of the pigment...
2016: Chemistry Central Journal
Caren Kurgat, Joshua Kibet, Peter Cheplogoi
BACKGROUND: Consensus of opinion in literature regarding tobacco research has shown that cigarette smoke can cause irreparable damage to the genetic material, cell injury, and general respiratory landscape. The alkaloid family of tobacco has been implicated is a series of ailments including addiction, mental illnesses, psychological disorders, and cancer. Accordingly, this contribution describes the mechanistic degradation of major tobacco alkaloids including the widely studied nicotine and two other alkaloids which have received little attention in literature...
2016: Chemistry Central Journal
Wenjian Xie, Hongjie Zhang, Jianguo Zeng, Hubiao Chen, Zhongzhen Zhao, Zhitao Liang
BACKGROUND: The dry root of Salvia miltiorrhiza Bunge (Danshen in Chinese) is an used-widely traditional Chinese herbal medicine with and promising efficacy. This herbal plant has been extensively cultivated in China. Currently, people usually rely on its morphological features to evalaute its pharmaceutical quality. In this study, laser micro-dissection system (LMD) was applied to isolate single fresh tissue of root of S. miltiorrhiza. Under fluorescent microscopic model, five tissues namely cork, cortex, phloem, xylem ray and vessel were well recognized and isolated accurately by LMD, respectively and then the distribution pattern of the major bioactive compounds in various tissues was investigated by ultra-performance liquid chromatography-quadrupole/time of flight-mass spectrometry, which aims to validate the traditional experience on evaluating pharmaceutical quality of Danshen by morphological features...
2016: Chemistry Central Journal
Mitja Ogrizek, Janez Konc, Urban Bren, Milan Hodošček, Dušanka Janežič
A protein, Tm1631 from the hyperthermophilic organism Thermotoga maritima belongs to a domain of unknown function protein family. It was predicted that Tm1631 binds with the DNA and that the Tm1631-DNA complex is an endonuclease repair system with a DNA repair function (Konc et al. PLoS Comput Biol 9(11): e1003341, 2013). We observed that the severely bent, strained DNA binds to the protein for the entire 90 ns of classical molecular dynamics (MD) performed; we could observe no significant changes in the most distorted region of the DNA, where the cleavage of phosphodiester bond occurs...
2016: Chemistry Central Journal
Peng Lei, Xuebo Zhang, Yan Xu, Gaofei Xu, Xili Liu, Xinling Yang, Xiaohe Zhang, Yun Ling
BACKGROUND: Take-all of wheat, caused by the soil-borne fungus Gaeumannomyces graminis var. tritici, is one of the most important and widespread root diseases. Given that take-all is still hard to control, it is necessary to develop new effective agrochemicals. Pyrazole derivatives have been often reported for their favorable bioactivities. In order to discover compounds with high fungicidal activity and simple structures, 1,2,3,4-tetrahydroquinoline, a biologically active group of natural products, was introduced to pyrazole structure...
2016: Chemistry Central Journal
Ming-Chuan Liu, Sheng-Jie Yang, Da Hong, Jin-Ping Yang, Min Liu, Yun Lin, Chia-Hui Huang, Chao-Jih Wang
BACKGROUND: Walnut (Juglans regia L.), that belongs to the Juglandaceae family, is one of the nuts commonly found in Chinese diets. Researchers had obtained peptides from walnut protein hydrolysates, and these peptides exhibited the high antioxidant activities. The objective of this study was to develop a simple and convenient method for a facile and reproducible preparation of antioxidant peptides from walnut protein hydrolysates. RESULTS: Walnut proteins were extracted from walnut kernels using continuous countercurrent extraction process, and were separately hydrolyzed with six types of proteases (neutrase, papain, bromelain, alcalase, pepsin, and pancreatin)...
2016: Chemistry Central Journal
Ismail Warad, Fuad Al-Rimawi, Assem Barakat, Saida Affouneh, Naveen Shivalingegowda, Neartur Krishnappagowda Lokanath, Ibrahim M Abu-Reidah
BACKGROUND: The coordination chemistry of cadmium(II) with diamine ligands is of particular interest. The most common structure around cadmium(II) center in their complexes is tetrahedral, that is due the octet rule obeyed. Nevertheless, five and six-coordinated complexes are also well known. Now a day, many cadmium(II) complexes with chelate ligands were synthesized for their structural or applications properties. Antibacterial activities and DNA binding affinity of this class of cadmium complexes have attracted considerable interest...
2016: Chemistry Central Journal
Ismat H Ali, H A Alrafai
BACKGROUND: Kinetics, thermodynamics and equilibrium of the removal of chromium(VI) ions from aqueous solutions by using chemically activated leaves of Ficus nitida were investigated. Adsorption runs were performed as a function of pH, mass of biosorbent, contact time, initial concentration of chromium(VI) ions and temperature. RESULTS: The optimum conditions for maximum removal of chromium(VI) ion from aqueous solutions (about 99 %) were found to be 0.80 g of chemically activated leaves of F...
2016: Chemistry Central Journal
Ajona Megalathan, Sajeewani Kumarage, Ayomi Dilhari, Manjula M Weerasekera, Siromi Samarasinghe, Nilwala Kottegoda
Currently, there is an increased scientific interest to discover plant based drug formulations with improved therapeutic potential. Among the cornucopia of traditional medicinal plants, Curcuma longa rhizomes have been used as a powerful antibacterial and antifungal agent. However, its practical applications are limited due to its instability under thermal and UV radiation and its low bioavailability and the extensive procedures needed for isolation. This study focuses on exploring the potential of nanotechnology-based approaches to stabilize the natural curcuminoids, the major active components in turmeric without the need for its isolation, and to evaluate the release characteristics, stability and antimicrobial activity of the resulting nanohybrids...
2016: Chemistry Central Journal
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