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Chemistry Central Journal

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https://www.readbyqxmd.com/read/28360933/extraction-purification-characterization-and-antioxidant-activities-of-polysaccharides-from-ramaria-botrytis-pers-ricken
#1
Hua Li
BACKGROUND: Ramaria botrytis (Pers.) Ricken, a member of the family Clavariaceae, has been widely prescribed for anti-aging and improving immunity. To extract and purify the polysaccharides, the main constituent of the fruiting-body, from R. botrytis and explore antioxidant activities was great significant. RESULTS: Ramaria botrytis polysaccharides (RBP) was extracted with water at 88.47 °C for 1.42 h with a solution to sample ratio of 10.94 mL g(-1) employing response surface methodology...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28360932/synthesis-and-in-vitro-antitumor-activity-of-1e-4e-1-aryl-5-2-quinazolin-4-yl-oxy-phenyl-1-4-pentadien-3-one-derivatives
#2
Hui Luo, Shengjie Yang, Da Hong, Wei Xue, Pu Xie
BACKGROUND: Cancer is one of the leading causes of death and only second to heart diseases. Recently, preclinical studies have demonstrated that curcumin had a number of anticancer properties. Thus, we planned to synthesize a series of curcumin analogs to assess their antiproliferation efficacy. RESULTS: A series of (1E,4E)-1-aryl-5-(2-((quinazolin-4-yl)oxy)phenyl)-1,4-pentadien-3-one derivatives (curcumin analogs) were synthesized and characterized by IR, NMR, and elemental analysis techniques...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28326128/citric-acid-emerging-applications-of-key-biotechnology-industrial-product
#3
REVIEW
Rosaria Ciriminna, Francesco Meneguzzo, Riccardo Delisi, Mario Pagliaro
Owing to new biotechnological production units mostly located in China, global supply of citric acid in the course of the last two decades rose from less than 0.5 to more than 2 million tonnes becoming the single largest chemical obtained via biomass fermentation and the most widely employed organic acid. Critically reviewing selected research achievements and production trends, we identify the reasons for which this polycarboxylic acid will become a key chemical in the emerging bioeconomy.Graphical abstractPalermo's Fabbrica Chimica Italiana Goldenberg today...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28293282/modeling-and-optimization-of-nanoemulsion-containing-sorafenib-for-cancer-treatment-by-response-surface-methodology
#4
Zahra Izadiyan, Mahiran Basri, Hamid Reza Fard Masoumi, Roghayeh Abedi Karjiban, Norazlinaliza Salim, Kamyar Shameli
The aim of this study is the development of nanoemulsions for intravenous administration of Sorafenib, which is a poorly soluble drug with no parenteral treatment. The formulation was prepared by a high energy emulsification method and optimized by response surface methodology. The effects of overhead stirring time, high shear rate, high shear time, and cycles of high-pressure homogenizer were studied in the preparation of nanoemulsion loaded with Sorafenib. Most of the particles in nanoemulsion are spherical in shape, the smallest particle size being 82...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28293281/synthesis-and-protective-effect-of-new-ligustrazine-vanillic-acid-derivatives-against-cocl2-induced-neurotoxicity-in-differentiated-pc12-cells
#5
Bing Xu, Xin Xu, Chenze Zhang, Yuzhong Zhang, GaoRong Wu, Mengmeng Yan, Menglu Jia, Tianxin Xie, Xiaohui Jia, Penglong Wang, Haimin Lei
Ligustrazine-vanillic acid derivatives had been reported to exhibit promising neuroprotective activities. In our continuous effort to develop new ligustrazine derivatives with neuroprotective effects, we attempted the synthesis of several ligustrazine-vanillic acid amide derivatives and screened their protective effect on the injured PC12 cells damaged by CoCl2. The results showed that most of the newly synthesized derivatives exhibited higher activity than ligustrazine, of which, compound VA-06 displayed the highest potency with EC50 values of 17...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28286547/identification-of-the-aroma-compounds-in-vitex-doniana-sweet-free-and-bound-odorants
#6
Ola Lasekan
BACKGROUND: Most often, the glycosidically-bound aroma compounds are released during industrial processing or pre-treatment of fruits. This usually introduces modification to the aroma notes of such fruits. Therefore, there is the need to understand the contribution of these bound aroma compounds to the overall aroma of a given fruit. In recent years research studies have reported on the free- and bound volatile compounds of several fruits. However, there is no report yet on Vitex doniana sweet...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28261323/a-brief-review-of-recent-developments-in-the-designs-that-prevent-bio-fouling-on-silicon-and-silicon-based-materials
#7
REVIEW
Xiaoning Zhang, DaShan Brodus, Valerie Hollimon, Hongmei Hu
Silicon and silicon-based materials are essential to our daily life. They are widely used in healthcare and manufacturing. However, silicon and silicon-based materials are susceptible to bio-fouling, which is of great concern in numerous applications. To date, interdisciplinary research in surface science, polymer science, biology, and engineering has led to the implementation of antifouling strategies for silicon-based materials. However, a review to discuss those antifouling strategies for silicon-based materials is lacking...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28246546/purification-characterization-and-procoagulant-activity-of-polysaccharides-from-angelica-dahurice-roots
#8
Jinmei Wang, Pengli Lian, Qi Yu, Jinfeng Wei, Wen-Yi Kang
Five polysaccharides, namely ADPs-1a, ADPs-1b, ADPs-2, ADPs-3a and ADPs-3b, were extracted from Angelicae dahuricae Radix, purified, and identified by high performance gel permeation chromatography (HPSEC), gas chromatography (GC), Fourier transform infrared (FT-IR) spectrometer and nuclear magnetic resonance spectra (NMR), including the determination of procoagulant activity in vitro. The average molecular weight (Mw) of the polysaccharides was 153,800, 8312, 111,700, 3766 and 96,680 g/mol, respectively. Coagulation assays indicated that ADPs-1b, ADPs-2, ADPs-3a and ADPs-3b had procoagulant activities...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28246545/design-synthesis-and-biological-potentials-of-novel-tetrahydroimidazo-1-2-a-pyrimidine-derivatives
#9
Jyoti Rani, Monika Saini, Sanjiv Kumar, Prabhakar Kumar Verma
BACKGROUND: A novel series of 5-(substituted aldehyde)-7-methyl-3-oxo-N-phenyl-2-((3,4,5,6-tetrahydroxytetrahydro-2H-pyran-2-yl)methylene)-1,2,3,5-tetrahydroimidazo[1,2-a]pyrimidine-6-carboxamide analogues (1-24) was synthesized using the Biginelli condensation. RESULTS AND DISCUSSION: The synthesized compounds were screened for their in vitro antimicrobial potential against Gram (positive and negative) bacterial and fungal strains by tube dilution technique. In the series, compound 15 exhibited significant antimicrobial activity against Candida albicans and Aspergillus niger with MIC value = 1...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28224018/2-benzyl-benzofurans-from-the-tubers-of-ophiopogon-japonicus
#10
Nguyen Hai Dang, Nguyen Dinh Chung, Ha Manh Tuan, Nguyen Van Thanh, Nguyen Tuan Hiep, Dongho Lee, Nguyen Tien Dat
BACKGROUND: The overproduction of nitric oxide (NO) is known to involve in various inflammatory processes. A methanol extract of the tubers of Ophiopogon japonicus was found to strongly inhibit NO production. The present paper deals with the isolation, structural identification and NO inhibitory effect of five compounds isolated from the MeOH extract of O. japonicus tubers. RESULTS: Three new compounds were elucidated to be (2R)-(4-methoxybenzyl)-5,7-dimethyl-6-hydroxyl-2,3-dihydrobenzofuran (1), 2-(2-hydroxyl-4-methoxy-benzyl)-5-methyl-6-methoxyl-2,3-dihydrobenzofuran (2), and 2-(4-hydroxy-benzyl)-5,6-dihydroxybenzofuran (3)...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28224017/the-effect-of-carbamic-acid-1-2-3-thiadiazole-4-ylcarbonyl-hexyl-ester-on-peronophythora-litchii-infection-quality-and-physiology-of-postharvest-litchi-fruits
#11
Hai Liu, Guoxing Jing, Yueming Jiang, Fuying Luo, Zaifeng Li
BACKGROUND: Litchi (Litchi chinensis Sonn.) is a subtropical fruit with attractive characteristic of white to creamy semitranslucent flesh and red color in pericap, but it was easily subjected to the infection of Peronophythora litchii and lost its market values. Experiments were conducted to understand the effect of [Carbamic acid, (1,2,3-thiadiazole-4-ylcarbonyl)-hexyl ester, CTE] on the growth of P. litchi and quality properties in litchi fruits during postharvest storage. RESULTS: In vitro experiments, CTE with minimum inhibitory concentration (MIC, 5 mg/L) and minimum fungicidal concentration (MFC, 10 mg/L) were against the growth of P...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28224016/characterization-of-major-metabolites-of-polymethoxylated-flavonoids-in-pericarpium-citri-reticulatae-using-liver-microsomes-immobilized-on-magnetic-nanoparticles-coupled-with-uplc-ms-ms
#12
Jun Lei, Ying Xue, Yi-Ming Liu, Xun Liao
The peels of citrus fruits (Pericarpium Citri Reticulatae, PCR) have long been used in traditional Chinese medicines (TCMs). Polymethoxylated flavonoids (PMFs) were found to be the main components present in PCR extracts, but their metabolism remains unclear which restrain the utilization of this TCM. In the present work, rat liver microsomes were immobilized on magnetic nanoparticles (LMMNPs) for in vitro metabolic study on the whole PMFs of PCR. LMMNPs were characterized by transmission electron microscope and Fourier-transform infrared spectrum...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28203273/synthesis-and-biological-evaluation-of-the-new-1-3-dimethylxanthine-derivatives-with-thiazolidine-4-one-scaffold
#13
Sandra Constantin, Florentina Geanina Lupascu, Maria Apotrosoaei, Ioana Mirela Vasincu, Dan Lupascu, Frederic Buron, Sylvain Routier, Lenuta Profire
BACKGROUND: The xanthine structure has proved to be an important scaffold in the process of developing a wide variety of biologically active molecules such as bronchodilator, hypoglycemiant, anticancer and anti-inflammatory agents. It is known that hyperglycemia generates reactive oxygen species which are involved in the progression of diabetes mellitus and its complications. Therefore, the development of new compounds with antioxidant activity could be an important therapeutic strategy against this metabolic syndrome...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28194226/cheminformatics-studies-to-analyze-the-therapeutic-potential-of-phytochemicals-from-rhazya-stricta
#14
Abdullah Y Obaid, Sreedhara Voleti, Roop Singh Bora, Nahid H Hajrah, Abdulkader M Shaikh Omer, Jamal S M Sabir, Kulvinder Singh Saini
Rhazya stricta is a unique medicinal plant source for many indole alkaloids, non-alkaloids, flavonoids, triterpenes and other unknown molecules with tremendous potential for therapeutic applications against many diseases. In the present article, we generated computational data on predictive properties and activity across two key therapeutic areas of cancer and obesity, and corresponding cheminformatics studies were carried out to examine druggable properties of these alkaloids. Computed physiochemical properties of the 78 indole alkaloids from R...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28184241/thermal-degradation-of-aqueous-2-aminoethylethanolamine-in-co2-capture-identification-of-degradation-products-reaction-mechanisms-and-computational-studies
#15
Idris Mohamed Saeed, Vannajan Sanghiran Lee, Shaukat Ali Mazari, B Si Ali, Wan Jeffrey Basirun, Anam Asghar, Lubna Ghalib, Badrul Mohamed Jan
Amine degradation is the main significant problems in amine-based post-combustion CO2 capture, causes foaming, increase in viscosity, corrosion, fouling as well as environmental issues. Therefore it is very important to develop the most efficient solvent with high thermal and chemical stability. This study investigated thermal degradation of aqueous 30% 2-aminoethylethanolamine (AEEA) using 316 stainless steel cylinders in the presence and absence of CO2 for 4 weeks. The degradation products were identified by gas chromatography mass spectrometry (GC/MS) and liquid chromatography-time-of-flight-mass spectrometry (LC-QTOF/MS)...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28123451/green-solvents-and-technologies-for-oil-extraction-from-oilseeds
#16
REVIEW
S P Jeevan Kumar, S Rajendra Prasad, Rintu Banerjee, Dinesh K Agarwal, Kalyani S Kulkarni, K V Ramesh
Oilseeds are crucial for the nutritional security of the global population. The conventional technology used for oil extraction from oilseeds is by solvent extraction. In solvent extraction, n-hexane is used as a solvent for its attributes such as simple recovery, non-polar nature, low latent heat of vaporization (330 kJ/kg) and high selectivity to solvents. However, usage of hexane as a solvent has lead to several repercussions such as air pollution, toxicity and harmfulness that prompted to look for alternative options...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28123450/a-conceptual-dft-study-of-the-molecular-properties-of-glycating-carbonyl-compounds
#17
Juan Frau, Daniel Glossman-Mitnik
Several glycating carbonyl compounds have been studied by resorting to the latest Minnesota family of density functional with the objective of determinating their molecular properties. In particular, the chemical reactivity descriptors that arise from conceptual density functional theory and chemical reactivity theory have been calculated through a [Formula: see text]SCF protocol. The validity of the KID (Koopmans' in DFT) procedure has been checked by comparing the reactivity descriptors obtained from the values of the HOMO and LUMO with those calculated through vertical energy values...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28123449/enhanced-antibacterial-activity-of-tio2-nanoparticle-surface-modified-with-garcinia-zeylanica-extract
#18
U L N H Senarathna, S S N Fernando, T D C P Gunasekara, M M Weerasekera, H G S P Hewageegana, N D H Arachchi, H D Siriwardena, P M Jayaweera
BACKGROUND: The antibacterial activity of 21 nm TiO2 nanoparticles (NPs) and particles modified with Garcinia zeylanica (G. zeylanica) against Methicillin resistant Staphylococcus aureus was investigated in the presence and absence of light. RESULTS: Surface modification of TiO2 NPs with the adsorption of G. zeylanica extract, causes to shift the absorption edge of TiO2 NPs to higher wavelength. TiO2 NPs, G. zeylanica pericarp extract showed significant bactericidal activity which was further enhanced in contact with the TiO2 modified G...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28123448/optimization-of-microwave-assisted-extraction-of-zerumbone-from-zingiber-zerumbet-l-rhizome-and-evaluation-of-antiproliferative-activity-of-optimized-extracts
#19
Ali Ghasemzadeh, Hawa Z E Jaafar, Asmah Rahmat, Mallappa Kumara Swamy
BACKGROUND: The extraction of bioactive compounds from herbal materials requires optimization in order to recover the highest active dose. Response surface methodology was used to optimize variables affecting the microwave extraction of zerumbone from Zingiber zerumbet using the Box-Behnken design. The influence of variables, such as ethanol concentration (X1), microwave power (X2), irradiation time (X3), and liquid-to-solid ratio (X4), on the extraction of zerumbone was modeled using a second-order regression equation...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28119762/synthesis-spectroscopic-dielectric-molecular-docking-and-dft-studies-of-3e-3-4-methylbenzylidene-3-4-dihydro-2h-chromen-2-one-an-anticancer-agent
#20
T Beena, L Sudha, A Nataraj, V Balachandran, D Kannan, M N Ponnuswamy
BACKGROUND: Coumarin (2H-chromen-2-one) and its derivatives have a wide range of biological and pharmaceutical activities. They possess antitumor, anti-HIV, anticoagulant, antimicrobial, antioxidant, and anti-inflammatory activities. Synthesis and isolation of coumarins from different species have attracted the attention of medicinal chemists. Herein, we report the synthesis, molecular structure, dielectric, anticancer activity and docking studies with the potential target protein tankyrase...
2017: Chemistry Central Journal
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