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Chemistry Central Journal

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https://www.readbyqxmd.com/read/28101131/using-flow-technologies-to-direct-the-synthesis-and-assembly-of-materials-in-solution
#1
REVIEW
K Robertson
In the pursuit of materials with structure-related function, directing the assembly of materials is paramount. The resultant structure can be controlled by ordering of reactants, spatial confinement and control over the reaction/crystallisation times and stoichiometries. These conditions can be administered through the use of flow technologies as evidenced by the growing widespread application of microfluidics for the production of nanomaterials; the function of which is often dictated or circumscribed by size...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28101130/silica-titania-xerogel-doped-with-mo-p-heteropoly-compounds-for-solid-phase-spectrophotometric-determination-of-ascorbic-acid-in-fruit-juices-pharmaceuticals-and-synthetic-urine
#2
Maria A Morosanova, Elena I Morosanova
BACKGROUND: Ascorbic acid is one of the most important vitamins to monitor in dietary sources (juices and vitamins) and biological liquids. RESULTS: Silica and silica-titania xerogels doped with Mo,P-heteropoly compounds (HPC) have been synthesized varying titanium(IV) and HPC content in sol. Their surface area and porosity have been studied with nitrogen adsorption and scanning electron microscopy, their elemental composition has been studied with energy-dispersive X-ray analysis...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28101129/a-traditional-poly-herbal-medicine-le-pana-guliya-induces-apoptosis-in-hepg2-and-hela-cells-but-not-in-cc1-cells-an-in-vitro-assessment
#3
Nekadage Don Amal Wageesha, Preethi Soysa, Keerthi Atthanayake, Muhammad Iqbal Choudhary, Mahinda Ekanayake
"Le Pana Guliya" (LPG) is a polyherbal formulation which is used to treat different types of cancers in traditional medicine. In this study we describe in vitro efficacy and mechanism of action of LPG on two cancer cell lines (HepG2 and HeLa) compared with a normal cell line CC1. The MTT, LDH assays and protein synthesis were used to study antiproliferative activity of LPG while NO synthesis and GSH content were assayed to determine the oxidative stress exerted by LPG. Rhodamine 123 staining, caspase 3 activity, DNA fragmentation and microscopic examination of cells stained with ethidium bromide/acridine orange were used to identify the apoptosis mechanisms associated with LPG...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28101128/simultaneous-determination-of-newly-developed-antiviral-agents-in-pharmaceutical-formulations-by-hplc-dad
#4
Nourah Zoman Al-Zoman, Hadir Mohamed Maher, Amal Al-Subaie
BACKGROUND: Ombitasvir/paritaprevir/ritonavir/dasabuvir (Viekira Pak(®)) are the newest medicines approved for use in the treatment of hepatitis C virus (HCV) and are available in tablet form as an oral combination. Specifically, these agents are indicated in the treatment of HCV in patients with genotype 1 infection. Due to the therapeutic importance and increased use of Viekira Pak, proper methods for its determination in bulk and pharmaceutical formulations must be developed. RESULTS: The present study describes the development and validation of a simple, rapid, selective and economical reverse phase high performance liquid chromatography-diode array detection (HPLC-DAD) method for the simultaneous determination of paritaprevir (PAR), ombitasvir (OMB), dasabuvir(DAS) and ritonavir (RIT) in bulk and pharmaceutical preparations...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28028386/in-vitro-drug-release-characteristic-and-cytotoxic-activity-of-silibinin-loaded-single-walled-carbon-nanotubes-functionalized-with-biocompatible-polymers
#5
Julia Meihua Tan, Govindarajan Karthivashan, Shafinaz Abd Gani, Sharida Fakurazi, Mohd Zobir Hussein
In this paper, we demonstrate the preparation of silibinin-loaded carbon nanotubes (SWSB) with surface coating agents via non-covalent approach as an effective drug delivery system. The resulting surface-coated SWSB nanocomposites are extensively characterized by Fourier transform infrared (FTIR) and Raman spectroscopies, ultraviolet-visible (UV-Vis) spectrometry and field emission scanning electron microscopy (FESEM). The FTIR and Raman studies show that an additional layer is formed by these coating agents in the prepared nanocomposites during the coating treatment and these results are confirmed by FESEM...
2016: Chemistry Central Journal
https://www.readbyqxmd.com/read/28028385/hplc-estimation-of-iothalamate-to-measure-glomerular-filtration-rate-in-humans
#6
Iltaf Shah, James Barker, Declan P Naughton, Stephen J Barton, Syed Salman Ashraf
Glomerular filtration rate (GFR) is usually determined by estimation of iothalamate (IOT) clearance. We have developed and validated an accurate and robust method for the analysis of IOT in human plasma and urine. The mobile phase consisted of methanol and 50 mM sodium phosphate (10:90; v/v). Flow rate was 1.2 mL/min on a C18 reverse phase column, Synergi-hydro (250 × 4.6 mm) 4 µm 80 Å, with an ultraviolet detector set to 254 nm. Acetonitrile was used for the deproteination and extraction of IOT from human plasma and urine...
2016: Chemistry Central Journal
https://www.readbyqxmd.com/read/27994641/colon-targeted-drug-delivery-of-branch-chained-disulphide-cross-linked-polymers-design-synthesis-and-characterisation-studies
#7
YongKhee Lau, Vuanghao Lim
Drug delivery directly to the colon is a very useful approach for treating localised colonic diseases such as inflammatory bowel disease, ulcerative colitis, and Crohn's disease. The use of disulphide cross-linked polymers in colon targeted drug delivery systems has received much attention because these polymers are redox sensitive, and the disulphide bonds are only cleaved by the low redox potential environment in the colon. The goal of this study was to synthesise tricarballylic acid-based trithiol monomers for polymerisation into branch-chained disulphide polymers...
2016: Chemistry Central Journal
https://www.readbyqxmd.com/read/27994640/analysis-of-tilianin-and-acacetin-in-agastache-rugosa-by-high-performance-liquid-chromatography-with-ionic-liquids-ultrasound-based-extraction
#8
Jinfeng Wei, Pengran Cao, Jinmei Wang, Wenyi Kang
Ionic liquid 1-butyl-3-methylimidazolium bromide-methanol-based ultrasonic-assisted extraction (ILUAE) was used to extract tilianin and acacetin from the aerial parts of Agastache rugose (A. rugose), and simultaneously determined by reversed phase high performance liquid chromatographic (RP-HPLC) method with ultraviolet detection (RP-HPLC-UV). An InertSustain RP-C18 column was used with the mobile phase consisting of methanol and 0.2% acetic acid as gradient elution at the detection wavelength of 332 nm. The flow rate was 0...
2016: Chemistry Central Journal
https://www.readbyqxmd.com/read/27994639/interpreting-comprehensive-two-dimensional-gas-chromatography-using-peak-topography-maps-with-application-to-petroleum-forensics
#9
Hamidreza Ghasemi Damavandi, Ananya Sen Gupta, Robert K Nelson, Christopher M Reddy
BACKGROUND: Comprehensive two-dimensional gas chromatography [Formula: see text] provides high-resolution separations across hundreds of compounds in a complex mixture, thus unlocking unprecedented information for intricate quantitative interpretation. We exploit this compound diversity across the [Formula: see text] topography to provide quantitative compound-cognizant interpretation beyond target compound analysis with petroleum forensics as a practical application. We focus on the [Formula: see text] topography of biomarker hydrocarbons, hopanes and steranes, as they are generally recalcitrant to weathering...
2016: Chemistry Central Journal
https://www.readbyqxmd.com/read/27994638/platelet-12-lipoxygenase-targeting-via-a-newly-synthesized-curcumin-derivative-radiolabeled-with-technetium-99m
#10
Reem Ibrahim Al-Wabli, Tamer Mostafa Mohamed Hafez Sakr, Mohammed Abdou Khedr, Adly Abdallah Selim, Mohamed Abd El-Motaleb Abd El-Rahman, Wafaa Abdou Zaghary
BACKGROUND: One of the most popular techniques for cancer detection is the nuclear medicine technique. The present research focuses on Platelet-12-lipoxygenase (P-12-LOX) as a promising target for treating and radio-imaging tumor tissues. Curcumin was reported to inhibit this enzyme via binding to its active site. RESULTS: A novel curcumin derivative was successfully synthesized and characterized with yield of 74%. It was radiolabeled with the diagnostic radioisotope technetium-99m with 84% radiochemical yield and in vitro stability up to 6 h...
2016: Chemistry Central Journal
https://www.readbyqxmd.com/read/27994637/surface-based-molecular-self-assembly-langmuir-blodgett-films-of-amphiphilic-ln-iii-complexes
#11
REVIEW
Dominic J Wales, Jonathan A Kitchen
The unique photophysical properties of the Ln(III) series has led to significant research efforts being directed towards their application in sensors. However, for "real-life" applications, these sensors should ideally be immobilised onto surfaces without loss of function. The Langmuir-Blodgett (LB) technique offers a promising method in which to achieve such immobilisation. This mini-review focuses on synthetic strategies for film formation, the effect that film formation has on the physical properties of the Ln(III) amphiphile, and concludes with examples of Ln(III) LB films being used as sensors...
2016: Chemistry Central Journal
https://www.readbyqxmd.com/read/27942267/synthesis-and-characterization-of-novel-rhenium-i-complexes-towards-potential-biological-imaging-applications
#12
Kokila Ranasinghe, Shiroma Handunnetti, Inoka C Perera, Theshini Perera
BACKGROUND: Re(I) tricarbonyl complexes exhibit immense potential as fluorescence imaging agents. However, only a handful of rhenium complexes have been utilized in biological imaging. The present study describes the synthesis of four novel rhenium complexes, their characterization and preliminary biological studies to assess their potential as biological imaging agents. RESULTS: Four facial rhenium tricarbonyl complexes containing a pyridyl triazine core, (L1 = 5,5'(3-(2-pyridyl)-1,2,4-triazine-5,6-diyl)-bis-2-furansulfonic acid disodium salt and L2 = (3-(2- pyridyl)-5,6-diphenyl-1,2,4-triazine-4',4''-disulfonic acid sodium salt) have been synthesized by utililzing two different Re metal precursors, Re(CO)5Br and [Re(CO)3(H2O)3]OTf in an organic solvent mixture and water, respectively...
2016: Chemistry Central Journal
https://www.readbyqxmd.com/read/27942266/modeling-the-transition-state-structure-to-probe-a-reaction-mechanism-on-the-oxidation-of-quinoline-by-quinoline-2-oxidoreductase
#13
Enyew A Bayle
BACKGROUND: Quinoline 2-oxidoreductase (Qor) is a member of molybdenum hydroxylase which catalyzes the oxidation of quinoline (2, 3 benzopyridine) to 1-hydro-2-oxoquinoline. Qor has biological and medicinal significances. Qor is known to metabolize drugs produced from quinoline for the treatment of malaria, arthritis, and lupus for many years. However, the mechanistic action by which Qor oxidizes quinoline has not been investigated either experimentally or theoretically. PURPOSE OF THE STUDY: The present study was intended to determine the interaction site of quinoline, predict the transition state structure, and probe a plausible mechanistic route for the oxidative hydroxylation of quinoline in the reductive half-reaction active site of Qor...
2016: Chemistry Central Journal
https://www.readbyqxmd.com/read/27928425/synthesis-of-acyl-oleanolic-acid-uracil-conjugates-and-their-anti-tumor-activity
#14
Wei-Bin Mo, Chun-Hua Su, Jia-Yan Huang, Jun Liu, Zhen-Feng Chen, Ke-Guang Cheng
BACKGROUND: Oleanolic acid, which can be isolated from many foods and medicinal plants, has been reported to possess diverse biological activities. It has been found that the acylation of the hydroxyl groups of the A-ring in the triterpene skeleton of oleanolic acid could be favorable for biological activities. The pyrimidinyl group has been constructed in many new compounds in various anti-tumor studies. RESULTS: Five acyl oleanolic acid-uracil conjugates were synthesized...
2016: Chemistry Central Journal
https://www.readbyqxmd.com/read/27853483/hydrotalcite-quinolinate-composites-as-catalysts-in-a-coupling-reaction
#15
Eloisa Ríos, Magali Hernández, Ilich A Ibarra, Ariel Guzmán, Enrique Lima
Samples of layered double hydroxides were prepared by a sol-gel procedure. Quinolinate Al(C9H6NO)3 units were added during the synthesis, leading to composite quinolinate hydrotalcite-like compounds. The amount of quinolinate was varied, showing that the number of organic building blocks determines the physicochemical properties of materials, which differ significantly from those commonly reported for hydrotalcites without any quinolinate. The order of layers, specific surface area and coordination of aluminium were the parameters most significantly influenced by the presence of the quinolinate as a part of the brucite-like layers...
2016: Chemistry Central Journal
https://www.readbyqxmd.com/read/27843488/dft-and-td-dft-calculation-of-new-thienopyrazine-based-small-molecules-for-organic-solar-cells
#16
Mohamed Bourass, Adil Touimi Benjelloun, Mohammed Benzakour, Mohammed Mcharfi, Mohammed Hamidi, Si Mohamed Bouzzine, Mohammed Bouachrine
BACKGROUND: Novel six organic donor-π-acceptor molecules (D-π-A) used for Bulk Heterojunction organic solar cells (BHJ), based on thienopyrazine were studied by density functional theory (DFT) and time-dependent DFT (TD-DFT) approaches, to shed light on how the π-conjugation order influence the performance of the solar cells. The electron acceptor group was 2-cyanoacrylic for all compounds, whereas the electron donor unit was varied and the influence was investigated. METHODS: The TD-DFT method, combined with a hybrid exchange-correlation functional using the Coulomb-attenuating method (CAM-B3LYP) in conjunction with a polarizable continuum model of salvation (PCM) together with a 6-31G(d,p) basis set, was used to predict the excitation energies, the absorption and the emission spectra of all molecules...
2016: Chemistry Central Journal
https://www.readbyqxmd.com/read/27822298/towards-emic-rational-design-setting-the-molecular-simulation-toolbox-for-enantiopure-molecularly-imprinted-catalysts
#17
REVIEW
Tessa Jalink, Tom Farrand, Carmelo Herdes
A critical appraisal of the current strategies for the synthesis of enantiopure drugs is presented, along with a systematic background for the computational design of stereoselective porous polymers. These materials aim to achieve the enantiomeric excess of any chiral drug, avoiding the racemic separation. Particular emphasis is given to link statistical mechanics methods to the description of each one of the experimental stages within the catalyst's synthesis, setting a framework for the fundamental study of the emerging field of molecularly imprinted catalysts...
2016: Chemistry Central Journal
https://www.readbyqxmd.com/read/27818708/investigation-on-the-self-association-of-an-inorganic-coordination-compound-with-biological-activity-casiope%C3%A3-na-iii-ia-in-aqueous-solution
#18
Alejandro Marín-Medina, Juan Carlos García-Ramos, Lena Ruíz-Azuara, Ernesto Carrillo-Nava
From studies using different experimental techniques employed to determine the presence of aggregates e.g. isothermal titration calorimetry, surface tension, electrical conductivity, UV-Vis spectrophotometry, dynamic and static light scattering, it is clearly demonstrated that the compound [Cu(4, 4'-dimethyl-2, 2'-bipyridine)(acetylacetonato)H2O]NO3 (Casiopeína III-ia), promising member of a family of new generation compounds for cancer treatment, is able to auto associate in aqueous media. Physicochemical properties associated with the formation of the aggregates were determined in pure water and in phosphate buffer media in order to simulate physiological conditions...
2016: Chemistry Central Journal
https://www.readbyqxmd.com/read/27812368/further-structure-activity-relationships-study-of-substituted-dithiolethiones-as-glutathione-inducing-neuroprotective-agents
#19
Dennis A Brown, Swati Betharia, Jui-Hung Yen, Ping-Chang Kuo, Hitesh Mistry
BACKGROUND: Parkinson's disease is a neurodegenerative disorder associated with oxidative stress and glutathione depletion. The induction of cellular glutathione levels by exogenous molecules is a promising neuroprotective approach to limit the oxidative damage that characterizes Parkinson's disease pathophysiology. Dithiolethiones, a class of sulfur-containing heterocyclic molecules, are known to increase cellular levels of glutathione; however, limited information is available regarding the influence of dithiolethione structure on activity...
2016: Chemistry Central Journal
https://www.readbyqxmd.com/read/27803730/quick-assessment-of-the-economic-value-of-olive-mill-waste-water
#20
Riccardo Delisi, Filippo Saiano, Mario Pagliaro, Rosaria Ciriminna
BACKGROUND: Olive biophenols are emerging as a valued class of natural products finding practical application in the food, pharmaceutical, beverage, cosmetic and nutraceutical industries due to their powerful biological activity which includes antioxidant and antimicrobial properties. Olive mill waste water (OMWW), a by-product in olive oil manufacturing, is rich in biophenols such as hydroxytyrosol and tyrosol. The amount of biophenols depends on the cultivar, the geographical area of cultivation, and the seasonal conditions...
2016: Chemistry Central Journal
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