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Journal of Breast Cancer

Yuying Qi, Tinghui Hu, Kai Lin, Renqing Ye, Zuodong Ye
[This retracts the article on p. 218 in vol. 18, PMID: 26472971.].
March 2018: Journal of Breast Cancer
Yoshika Nagata, Manabu Yoshioka, Hidetaka Uramoto, Yosuke Tsurudome, Sohsuke Yamada, Takeshi Hanagiri, Fumihiro Tanaka
Malignant melanoma rarely originates from the female nipple. Tumors that develop on the skin of the breast are often subject to a delayed diagnosis. Cytologic examination provides excellent diagnostic capabilities and is a safe procedure with a lower risk of local implantation, compared to needle or incisional biopsy. We herein report a patient who underwent surgical resection of a primary malignant melanoma of the nipple. An elastic soft nodule was observed on the left nipple, and no abnormal lesions were identified in the breast...
March 2018: Journal of Breast Cancer
Jeong Hyun Park, Se Kyung Lee, Jeong Eon Lee, Seok Won Kim, Seok Jin Nam, Ji-Yeon Kim, Jin-Seok Ahn, Won Park, Jonghan Yu, Yeon Hee Park
In this study, we aimed to evaluate the economic loss due to the diagnosis of breast cancer within the female South Korean working-age population. A population-based cost analysis was performed for cancer-related diagnoses between 1999 and 2014, using respective public government funded databases. Among the five most common cancers, breast cancer mortality was strongly associated with the growth in gross domestic product between 1999 and 2014 (R=0.98). In the female population, breast cancer represented the greatest productivity loss among all cancers, which was a consequence of the peak in the incidence of breast cancer during mid-working age in the working-age population, in addition to being the most common and fastest growing cancer among South Korean women...
March 2018: Journal of Breast Cancer
Jee Min Chung, Yongsik Jung, Young Pil Kim, Jinsue Song, Soyeon Kim, Ji Young Kim, Mira Kwon, Jung Hyun Yoon, Myo-Deok Kim, Jun-Kyoung Lee, Da-Yoon Chung, Seo Yun Lee, Jooseong Kang, Ho Chul Kang
Triple-negative breast cancer (TNBC) has a higher risk of death within 5 years of being diagnosed than the other forms of breast cancer. It is the second leading cause of death due to cancer among women. Currently, however, no diagnostic blood-based biomarker exists to identify the early stages of TNBC. To address this point, we utilized a human protein microarray system to identify serum autoantibodies that showed different expression patterns between TNBC and normal serum samples, and identified five autoantibodies showing TNBC-specific expression...
March 2018: Journal of Breast Cancer
Song-Hee Han, Milim Kim, Yul Ri Chung, Bo La Yun, Mijung Jang, Sun Mi Kim, Eunyoung Kang, Eun-Kyu Kim, So Yeon Park
Purpose: The management of benign intraductal papilloma (IDP) without atypia diagnosed on core needle biopsy (CNB) remains controversial. This study was performed to evaluate the rate of upgrading to malignancy or high-risk lesions after excision and to identify factors associated with upgrading using a large series of benign IDP cases without atypia. Methods: We included patients who were diagnosed as having benign IDP without atypia on CNB and underwent surgical or vacuum-assisted excision between 2010 and 2015...
March 2018: Journal of Breast Cancer
Sae Byul Lee, Guiyun Sohn, Jisun Kim, Il Yong Chung, Hee Jeong Kim, Beom Seok Ko, Jong Won Lee, Byung Ho Son, Sung-Bae Kim, Sei-Hyun Ahn
Purpose: This study aimed to chronologically evaluate survival of patients with breast cancer in Korea and investigate the observed changes during the last 20 years. We also sought to determine factors that may influence outcomes and changes in the duration of survival over time. Methods: We retrospectively analyzed a total of 10,988 patients with breast cancer who were treated at our institution between January 1993 and December 2008. We divided the study period into three periods (P1, 1993-1997; P2, 1998-2002; and P3, 2003-2008)...
March 2018: Journal of Breast Cancer
Bong Kyun Kim, Se Jeong Oh, Jeong-Yoon Song, Han-Byoel Lee, Min Ho Park, Yongsik Jung, Woo-Chan Park, Jina Lee, Woo Young Sun
Purpose: Breast cancer is one of the most common malignancies worldwide and the second most common cancer among Korean women. The prognosis of breast cancer is poor in patients with other primary cancers. However, there have been few clinical studies regarding this issue. Therefore, we analyzed the characteristics and prognosis of patients with breast cancer with multiple primary cancers (MPCs). Methods: Data from the Korean Breast Cancer Society Registry were analyzed...
March 2018: Journal of Breast Cancer
Wei Han, Cong Zhang, Xiao-Jiao Gao, Hua-Bing Wang, Fang Chen, Fang Cao, Yong-Wei Hu, Jun Ma, Xing Gu, Hou-Zhong Ding
Purpose: Five members of the zinc finger of the cerebellum (ZIC) family-ZIC1, ZIC2, ZIC3, ZIC4, and ZIC5-have been shown to be involved in various carcinomas. Here, we aimed to explore the clinicopathologic and prognostic roles of ZIC family members in invasive breast cancer patients using immunohistochemical analysis, western blotting analysis, and real-time quantitative polymerase chain reaction (RT-qPCR). Methods: A total of 241 female invasive breast cancer patients who underwent radical mastectomy between 2009 and 2011 were enrolled...
March 2018: Journal of Breast Cancer
Heejung Chae, Changhoon Yoo, Jung-A Yoon, Hee Jin Lee, Kyu-Pyo Kim, Jeong-Eun Kim, Jin-Hee Ahn, Kyung Hae Jung, Gyungyub Gong, Sung-Bae Kim
Purpose: The prognosis of human epidermal growth factor receptor 2 (HER2)-positive breast cancer has markedly improved since the introduction of trastuzumab. We aimed to evaluate the association between stromal tumor-infiltrating lymphocyte (sTIL) or FcrR polymorphisms and survival among patients with metastatic HER2-positive breast cancer who were treated with trastuzumab. Methods: A total of 56 women with recurrent or metastatic HER2-positive breast cancer who received the trastuzumab-taxane combination as first-line treatment were included in this retrospective analysis...
March 2018: Journal of Breast Cancer
Tae-Kyung Yoo, Myoung-Jin Jang, Eunshin Lee, Hyeong-Gon Moon, Dong-Young Noh, Wonshik Han
Purpose: An association between endocrine treatment-related symptoms and breast cancer recurrence has been suggested previously; however, conflicting results have been reported. We performed a meta-analysis of published studies to clarify this relationship. Methods: We systematically searched PubMed, Embase, Scopus, and the Cochrane database for studies investigating the association between endocrine treatment-related symptoms and patient survival. Random-effects meta-analysis was conducted with recurrence rate as the primary outcome...
March 2018: Journal of Breast Cancer
On-Yu Hong, Hyun Jo Youn, Hye-Yeon Jang, Sung Hoo Jung, Eun-Mi Noh, Hee Suk Chae, Young-Ju Jeong, Won Kim, Cheorl-Ho Kim, Jong-Suk Kim
Purpose: Peroxisome proliferator-activated receptor γ (PPARγ) is involved in the pathology of numerous diseases including atherosclerosis, diabetes, obesity, and cancer. Matrix metalloproteinases (MMPs) play a significant role in tissue remodeling related to various processes such as morphogenesis, angiogenesis, tissue repair, invasion, and metastasis. We investigated the effects of PPARγ on MMP expression and invasion in breast cancer cells. Methods: MCF-7 cells were cultured and then cell viability was monitored in an MTT assay...
March 2018: Journal of Breast Cancer
Yisun Jeong, Daeun You, Hyun-Gu Kang, Jonghan Yu, Seok Won Kim, Seok Jin Nam, Jeong Eon Lee, Sangmin Kim
Purpose: The exact mechanism regulating fibronectin (FN) expression in breast cancer cells has not been fully elucidated. In this study, we investigated the pharmacological mechanism of berberine (BBR) with respect to FN expression in triple-negative breast cancer (TNBC) cells. Methods: The clinical significance of FN mRNA expression was analyzed using the Kaplan-Meier plotter database ( FN mRNA and protein expression levels were analyzed by real-time polymerase chain reaction and western blotting, respectively...
March 2018: Journal of Breast Cancer
Banghua Wang, Jia Shen, Zexia Wang, Jianxia Liu, Zhifeng Ning, Meichun Hu
Purpose: Vascular endothelial growth factor (VEGF) signal transduction mainly depends on its binding to VEGF receptor 2 (VEGFR-2). VEGF downstream signaling proteins mediate several of its effects in cancer progression, including those on tumor growth, metastasis, and blood vessel formation. The activation of VEGFR-2 signaling is a hallmark of and is considered a therapeutic target for breast cancer. Here, we report a study of the regulation of the VEGFR-2 signaling pathway by a small molecule, isomangiferin...
March 2018: Journal of Breast Cancer
Sang Yull Kang, Yoo Seok Kim, Zisun Kim, Hyun-Yul Kim, Se Kyung Lee, Kyu-Won Jung, Hyun Jo Youn
The Korean Breast Cancer Society (KBCS) has established a nationwide breast cancer database using an online registration program in 1996. The present study aimed to analyze the basic findings and trends of breast cancer in Korea in 2015 using the data provided by the Korea Central Cancer Registry and the KBCS. In 2015, a total of 22,550 patients were newly diagnosed with breast cancer, of which 3,331 were carcinoma in situ cases and 19,219 were invasive cancer cases. The incidence rate of breast cancer in Korea has steadily increased since the nationwide database was established, and the crude rate and age-standardized rate including that of carcinoma in situ , were 88...
March 2018: Journal of Breast Cancer
Ji Young You, Hee Jung Suh, Yunju Kim, Jae Kwan Jun, Haydee Ojeda-Fournier, Kyounglan Ko
[This corrects the article on p. 304 in vol. 20, PMID: 28970857.].
December 2017: Journal of Breast Cancer
Hye-Joung Eom, Beom Seok Ko, In Hye Song, Gyungyub Gong, Hak Hee Kim
Ectopic breast tissue and male breast cancer are both very rare diseases with only a few reports in the literature. Here, we present the first case of ectopic male breast cancer in the perineum. The patient was a 70-year-old man with a palpable mass in the perineum. A wide local excision and inguinal lymph node dissection revealed invasive breast carcinoma of no special type involving the skin and subcutis, and inguinal lymph node metastases. Immunohistochemical staining showed that the tumor cells were strongly positive for estrogen and progesterone receptors and negative for human epidermal growth factor receptor 2...
December 2017: Journal of Breast Cancer
Tae-Kyung Yoo, Sung-Won Kim, Eunyoung Kang, Sung Gwe Ahn, Ki-Tae Hwang, Seung-Ki Kim, Sang Uk Woo, Hyuk Jai Shin, Young-Jin Song, Eun-Jung Jung, Myung-Chul Chang, Ilkyun Lee, Woo-Chan Park
Two consecutive surveys for breast surgeons in Korea were conducted to comprehend the practice patterns and perceptions on margin status after breast-conserving surgery. The surveys were conducted online in 2014 (initial) and 2016 (follow-up). A total of 126 and 88 responses were obtained in the initial and follow-up survey, respectively. More than 80% of the respondents replied to routinely apply frozen section biopsy for intraoperative margin assessment in both surveys. Re-excision recommendations of the margin for invasive cancer significantly changed from a close margin to a positive margin over time ( p =0...
December 2017: Journal of Breast Cancer
Yoojin Choi, Aeree Kim, Jinkyoung Kim, Jinhwan Lee, Soo Yeon Lee, Chungyeul Kim
Purpose: Breast cancer has a high prevalence in Korea. To achieve personalized therapy for breast cancer, long-term follow-up specimens are needed for next-generation sequencing (NGS) and multigene analysis. Formalin-fixed paraffin-embedded (FFPE) samples are easier to store than fresh frozen (FF) samples. The objective of this study was to optimize RNA extraction from FFPE blocks for NGS. Methods: RNA quality from FF and FFPE tissues (n=5), expected RNA amount per unit area, the relationship between archiving time and quantity/quality of FFPE-extracted RNA (n=14), differences in quantitative real-time polymerase chain reaction (qRT-PCR) and NGS results, and comparisons of both techniques with tissue processing at different institutions (n=96) were determined in this study...
December 2017: Journal of Breast Cancer
Young-Sil An, Yongsik Jung, Ji Young Kim, Sehwan Han, Doo Kyoung Kang, Seon Young Park, Tae Hee Kim
Purpose: The aims of our study were to correlate the degree of metabolic activity in normal glandular tissue measured on18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) with qualitative background parenchymal enhancement (BPE) grades on magnetic resonance imaging (MRI), and to investigate the change in standardized uptake value (SUV) according to the patients' menstrual cycles. Methods: From January 2013 to December 2015, 298 consecutive premenopausal patients with breast cancer who underwent both breast MRI and18 F-FDG PET/CT were identified...
December 2017: Journal of Breast Cancer
Hyung Suk Kim, Man Sik Shin, Chang Jong Kim, Sun Hyung Yoo, Tae Kyung Yoo, Yong Hwa Eom, Byung Joo Chae, Byung Joo Song
Purpose: Pathological complete response (pCR) of axillary lymph node (LN) is frequently achieved in patients with clinically node-positive breast cancer after neoadjuvant chemotherapy (NAC). Treatment of the axilla after NAC is not well established and the value of sentinel LN biopsy following NAC remains unclear. This study investigated the predictive value of axillary response following NAC and evaluated the predictive value of a model based on axillary response. Methods: Data prospectively collected on 201 patients with clinically node-positive breast cancer who were treated with NAC and underwent axillary LN dissection (ALND) were retrieved...
December 2017: Journal of Breast Cancer
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