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Journal of Breast Cancer

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https://www.readbyqxmd.com/read/28053638/erratum-lentivirus-mediated-short-hairpin-rna-targeting-protein-phosphatase-4-regulatory-subunit-1-inhibits-growth-in-breast-cancer
#1
Yuying Qi, Tinghui Hu, Kai Lin, Renqing Ye, Zuodong Ye
[This corrects the article on p. 218 in vol. 18, PMID: 26472971.].
December 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28053637/comment-to-patients-with-concordant-triple-negative-phenotype-between-primary-breast-cancers-and-corresponding-metastases-have-poor-prognosis
#2
COMMENT
Kadri Altundag
No abstract text is available yet for this article.
December 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28053636/increased-malignant-microcalcifications-after-neoadjuvant-chemotherapy-in-advanced-breast-cancer
#3
Gi Won Shin, Young Mi Park, Hye Kyoung Yoon, Soo Jin Jung, Tae Hyun Kim, Anbok Lee, Seok Mo Lee
In patients with advanced breast cancer, most new calcifications detected on a mammogram after neoadjuvant chemotherapy are benign dystrophic calcifications, but this is not always observed. We present a patient with advanced breast cancer who had paradoxically increased malignant microcalcifications concomitant with primary tumor regression after undergoing neoadjuvant chemotherapy. After the neoadjuvant chemotherapy, the follow-up mammogram revealed that local, fine pleomorphic microcalcifications had markedly increased...
December 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28053635/relapse-of-biphenotypic-acute-leukemia-as-a-breast-mass
#4
Hee-Chul Shin
In acute leukemia, leukemic infiltration of the breast is extremely rare. We report a case of biphenotypic acute leukemia (BAL) that presented as a breast mass. A 30-year-old woman presented with a 4-month history of a right breast mass with nipple discharge and easy fatigue. She had received chemotherapy and peripheral blood stem cell transplantation for BAL and had been in complete remission for the last 2 years. Core needle biopsy of the breast mass revealed monomorphous infiltrates of blast cells with round nuclei and fine chromatin, consistent with leukemic infiltration...
December 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28053634/persistent-pain-after-breast-cancer-treatment-a-questionnaire-based-study-on-the-prevalence-associated-treatment-variables-and-pain-type
#5
Alexander Andersen Juhl, Peer Christiansen, Tine Engberg Damsgaard
PURPOSE: Persistent pain is a common side effect of breast cancer treatment. The present study aimed to assess the prevalence, associated treatment-related factors, and the type of pain (neuropathic or nociceptive) in patients who had undergone a unilateral mastectomy. METHODS: All women who underwent a unilateral mastectomy at a University Hospital between 2009 and 2013 were eligible for inclusion. Women with breast reconstruction or active cancer were excluded...
December 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28053633/addition-of-digital-breast-tomosynthesis-to-full-field-digital-mammography-in-the-diagnostic-setting-additional-value-and-cancer-detectability
#6
Mirinae Seo, Jung Min Chang, Sun Ah Kim, Won Hwa Kim, Ji He Lim, Su Hyun Lee, Min Sun Bae, Hye Ryoung Koo, Nariya Cho, Woo Kyung Moon
PURPOSE: The purpose of this study was to assess the value of adding digital breast tomosynthesis (DBT) to full-field digital mammography (FFDM) in the diagnostic workup of breast cancer and to determine which lesion variables affect cancer detectability in the combined modality. METHODS: Between March and May 2012, paired FFDM and DBT images were obtained from 203 women as part of a diagnostic workup for breast cancer. Images from FFDM alone, DBT alone, and DBT combined with FFDM were reviewed in separate sessions by six blinded readers...
December 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28053632/detectability-and-usefulness-of-automated-whole-breast-ultrasound-in-patients-with-suspicious-microcalcifications-on-mammography-comparison-with-handheld-breast-ultrasound
#7
Jae Jeong Choi, Sung Hun Kim, Bong Joo Kang, Byung Joo Song
PURPOSE: The purpose of this study was to prospectively evaluate the detectability and usefulness of automated whole breast ultrasound (AWUS) and to compare it with handheld breast ultrasound (HHUS) in cases with suspicious microcalcifications identified by mammography. METHODS: Forty-two patients with 43 suspicious microcalcifications (25 malignant and 18 benign) detected by mammography underwent AWUS, HHUS, and histol-ogic examination. With knowledge of the mammographic findings, HHUS was performed to assess the visibility of the microcalcifications and the presence of associated masses or ductal changes...
December 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28053631/preoperative-magnetic-resonance-imaging-and-survival-outcomes-in-t1-2-breast-cancer-patients-who-receive-breast-conserving-therapy
#8
Jaegyu Ryu, Hyung Seok Park, Sanghwa Kim, Jee Ye Kim, Seho Park, Seung Il Kim
PURPOSE: The purpose of the study was to evaluate the effect of preoperative magnetic resonance imaging (MRI) on survival outcomes for breast cancer. METHODS: A total of 954 patients who had T1-2 breast cancer and received breast-conserving therapy (BCT) between 2007 and 2010 were enrolled. We divided the patients according to whether they received preoperative MRI or not. Survival outcomes, including locoregional recurrence-free survival (LRRFS), recurrence-free survival (RFS), and overall survival (OS), were analyzed...
December 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28053630/displacement-of-surgical-clips-during-postoperative-radiotherapy-in-breast-cancer-patients-who-received-breast-conserving-surgery
#9
SooYoon Sung, Joo Hwan Lee, Jong Hoon Lee, Sung Hwan Kim, Yoo-Kang Kwak, Sea-Won Lee, Ye Won Jeon, Young Jin Suh
PURPOSE: Surgical clips are used as a target for postoperative breast radiotherapy, and displacement of surgical clips would result in inaccurate delivery of radiation. We investigated the displacement range of surgical clips in the breast during postoperative radiotherapy following breast-conserving surgery. METHODS: A total of 178 patients who received breast-conserving surgery and postoperative radiation of 59.4 Gy in 33 fractions to the involved breast for 6...
December 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28053629/predictive-factors-for-upgrading-patients-with-benign-breast-papillary-lesions-using-a-core-needle-biopsy
#10
Young Ran Hong, Byung Joo Song, Sang Seol Jung, Bong Joo Kang, Sung Hun Kim, Byung Joo Chae
PURPOSE: Intraductal papilloma (IDP) is a benign breast disease with malignant potential, for which complete surgical excision is usually recommended. The aim of the present study was to investigate predictive factors for upgrading patients with a benign papillary lesion (BPL). METHODS: This study was an observational study using a prospectively collected cohort. In total, 13,049 patients who underwent a core needle biopsy (CNB) for a breast lesion between January 2009 and May 2015 were enrolled...
December 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28053628/chemotherapy-induced-left-ventricular-dysfunction-in-patients-with-breast-cancer
#11
Hyun Ju Yoon, Kye Hun Kim, Jong Yoon Kim, Hyuk Jin Park, Jae Yeong Cho, Young Joon Hong, Hyung Wook Park, Ju Han Kim, Youngkeun Ahn, Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park
PURPOSE: As the numbers of cancer cases and survivors increase, the incidence and natural history of chemotherapy-induced cardiotoxicities in patients with breast cancer may also be expected to change. The present study aimed to investigate the incidence and predictors of chemotherapy-induced left ventricular dysfunction (LVD) in patients with breast cancer. METHODS: From 2003 to 2010, 712 female patients with breast cancer (55.7±10.7 years) were enrolled and divided into the LVD group (n=82, 56...
December 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28053627/prognostic-significance-of-inner-quadrant-involvement-in-breast-cancer-treated-with-neoadjuvant-chemotherapy
#12
Ji Hyun Chang, Wan Jeon, Kyubo Kim, Kyung Hwan Shin, Wonshik Han, Dong-Young Noh, Seock-Ah Im, Tae-You Kim, Yung-Jue Bang
PURPOSE: In the present study, we aimed to evaluate the initial tumor location as a prognostic factor in breast cancer patients treated with neoadjuvant chemotherapy (NAC). METHODS: Between March 2002 and January 2007, a total of 179 patients with stage II/III breast cancer underwent NAC followed by breast surgery. Using physical and radiologic findings, patients were grouped by their initial tumor location into inner/both quadrant (upper/lower inner quadrant involvement +/- multicentric tumor involving outer quadrant; n=97) and outer quadrant (n=82) tumor groups...
December 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28053626/expression-of-t-lymphocyte-markers-in-human-epidermal-growth-factor-receptor-2-positive-breast-cancer
#13
Changro Lee, Seho Park, Joo Heung Kim, Sung Mook Lim, Hyung Seok Park, Seung Il Kim, Byeong-Woo Park
PURPOSE: The present study aimed to examine the clinical implications of CD4, CD8, and FOXP3 expression on the prognosis of human epidermal growth factor receptor 2 (HER2)-positive breast cancer using a web-based database, and to compare the immunohistochemical expression of T-lymphocyte markers using primary and metastatic HER2-positive tumor tissues before and after HER2-targeted therapy. METHODS: Using the cBioPortal for Cancer Genomics and Kaplan-Meier plotter, the mRNA expression, association between T-lymphocyte markers, and survival in HER2-positive cancers were investigated according to various cutoff levels...
December 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28053625/lipid-raft-integrity-is-required-for-survival-of-triple-negative-breast-cancer-cells
#14
Anil Badana, Madhuri Chintala, Gayathri Varikuti, Nagaseshu Pudi, Seema Kumari, Vijaya Rachel Kappala, Rama Rao Malla
PURPOSE: Lipid rafts are cholesterol enriched microdomains that colocalize signaling pathways involved in cell proliferation, metastasis, and angiogenesis. We examined the effect of methyl-β-cyclodextrin (MβCD)-mediated cholesterol extraction on the proliferation, adhesion, invasion, and angiogenesis of triple negative breast cancer (TNBC) cells. METHODS: We measured cholesterol and estimated cell toxicity. Detergent resistant membrane (DRM) and non-DRM fractions were separated using the OptiPrep gradient method...
December 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28053624/alkyl-cinnamates-induce-protein-kinase-c-translocation-and-anticancer-activity-against-breast-cancer-cells-through-induction-of-the-mitochondrial-pathway-of-apoptosis
#15
Suman Jyoti Deka, Narsimha Mamdi, Debasis Manna, Vishal Trivedi
PURPOSE: The protein kinase C (PKC) family of serine-threonine kinases plays an important role in cancer cell progression. Thus, molecules that target PKC have potential as anticancer agents. The current study aims to understand the treatment of breast cancer cells with alkyl cinnamates. We have also explored the mechanistic details of their anticancer action and the underlying molecular signaling. METHODS: 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed to measure the viability of MDAMB-231 breast cancer cells to assess the anticancer activity of these compounds...
December 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28053623/lncrna-taurine-upregulated-gene-1-promotes-cell-proliferation-by-inhibiting-microrna-9-in-mcf-7-cells
#16
Xiao-Bo Zhao, Guo-Sheng Ren
PURPOSE: This study was designed to investigate the role of taurine-upregulated gene 1 (TUG1) in MCF-7 breast cancer cells and the molecular mechanism involved in the regulation of microRNA-9 (miR-9). METHODS: The expression of TUG1 in breast cancer tissues and cells was evaluated using quantitative reverse transcription polymerase chain reaction. Cell viability was examined using a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay; cell cycle progression and apoptosis were analyzed using flow cytometry...
December 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28053622/role-of-ovarian-function-suppression-in-premenopausal-women-with-early-breast-cancer
#17
REVIEW
Woo-Chan Park
Historically, endocrine therapy for breast cancer began with ovarian ablation (OA) for the treatment of premenopausal patients. After the identification of estrogen receptors and the development of many antiestrogens, tamoxifen has been approved and used as the standard endocrine therapy for hormonal receptor (HR)-positive premenopausal patients to date. With the development of luteinizing hormone-releasing hormone agonists, the paradigm of endocrine therapy for premenopausal women with HR-positive breast cancer began to change from OA to ovarian function suppression (OFS)...
December 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/27721888/erratum-clinicopathologic-characteristics-of-breast-cancer-stem-cells-identified-on-the-basis-of-aldehyde-dehydrogenase-1-expression
#18
Yoon Seok Kim, Min Jung Jung, Dong Won Ryu, Chung Han Lee
[This corrects the article on p. 121 in vol. 17, PMID: 25013432.].
September 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/27721887/erratum-diagnostic-value-of-elastography-using-acoustic-radiation-force-impulse-imaging-and-strain-ratio-for-breast-tumors
#19
Yoon Seok Kim, Jung Gu Park, Beom Su Kim, Chung Han Lee, Dong Won Ryu
[This corrects the article on p. 76 in vol. 17, PMID: 24744801.].
September 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/27721886/comments-on-the-prognostic-impact-and-clinicopathological-correlation-of-cd133-and-aldh1-expression-in-invasive-breast-cancer-and-the-commentary-by-antonio-ieni-and-giovanni-tuccari
#20
COMMENT
Christine A Fargeas, Denis Corbeil
No abstract text is available yet for this article.
September 2016: Journal of Breast Cancer
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