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Journal of Breast Cancer

Isaac Kim, Jai Min Ryu, Jae-Myung Kim, Hee Jun Choi, Se Kyung Lee, Jong Hwan Yu, Jeong Eon Lee, Seok Won Kim, Seok Jin Nam
[This corrects the article on p. 270 in vol. 20, PMID: 28970853.].
June 2018: Journal of Breast Cancer
Ali Pourzand, Aynaz Tajaddini, Saeed Pirouzpanah, Mohammad Asghari-Jafarabadi, Nasser Samadi, Ali-Reza Ostadrahimi, Zohreh Sanaat
[This corrects the article on p. 292 in vol. 19, PMID: 27721879.].
June 2018: Journal of Breast Cancer
Bence Kővári, Katalin Ormándi, Zsolt Simonka, András Vörös, Gábor Cserni
Apocrine encapsulated papillary carcinoma (EPC) of the breast is a rare neoplasm, and only 10 cases have been reported in the literature to date. Although EPC by definition lacks a peripheral myoepithelial layer, all previously published apocrine EPC cases were clinically indolent and lacked a conventional invasive component. Herein, we report the 11th case of apocrine EPC, which had a conventional invasive carcinoma component and provides evidence of the malignant potential of this entity. We postulate that apocrine EPC is most likely a morphological variant of conventional EPC, with the same unpredictable malignant potential as non-apocrine cases...
June 2018: Journal of Breast Cancer
Jae-Myung Kim, Jai Min Ryu, Isaac Kim, Hee Jun Choi, Seok Jin Nam, Seok Won Kim, Jonghan Yu, Se Kyung Lee, Jeong Eon Lee
A recent study conducted at the University of Tennessee Medical Center using a large dataset from the National Cancer Database (NCDB) reported the use of nomograms for predicting Oncotype DX™ (ODX) scores with clinicopathologic data. We reviewed the data of 218 patients who underwent the ODX test at a single institution in Korea to confirm that nomograms can accurately predict ODX score groups using our data, which differ from those of the NCDB in terms of ethnicity. The concordance index (c-index) of nomograms was much lower than that of the University of Tennessee Medical Center for high- and low-risk groups of commercial ODX and Trial Assigning Individualized Options for Treatment values...
June 2018: Journal of Breast Cancer
Tai Suk Roh, Jae Yoon Kim, Bok Ki Jung, Joon Jeong, Sung Gwe Ahn, Young Seok Kim
Purpose: In properly selected patients with breast cancer, nipple-sparing mastectomy (NSM) is generally considered safe by oncologic standards. We examined two groups of patients who underwent direct-to-implant (DTI) reconstruction after NSM, comparing complications encountered, revision rates, and aesthetic outcomes. The patients were stratified based on type of surgical incision and assigned to inframammary fold (IMF) and non-IMF groups. Methods: We investigated 141 patients (145 breasts) subjected to NSM and immediate DTI reconstruction between 2013 and 2016...
June 2018: Journal of Breast Cancer
Won Kyung Cho, Won Park, Doo Ho Choi, Hyejung Cha, Seok Jin Nam, Seok Won Kim, Jeong Eon Lee, Jonghan Yu, Young-Hyuck Im, Jin Seok Ahn, Yeon Hee Park, Ji-Yeon Kim
Purpose: This study aimed to identify risk factors that have significant interaction with radiation exposure to the heart, and thus to determine candidates for heart-sparing radiotherapy (RT) among women with left breast cancer. Methods: We identified 4,333 patients who received adjuvant RT following breast-conserving surgery for ductal carcinoma in situ or invasive breast cancer from 1996 to 2010. Incidence rates of cardiovascular disease were compared between left-sided and right-sided RT, and stratified by age and risk factors such as body mass index (BMI), smoking, hyperlipidemia, hypertension, diabetes, administration of anthracycline, and trastuzumab...
June 2018: Journal of Breast Cancer
Milim Kim, Hyun Jeong Kim, Yul Ri Chung, Eunyoung Kang, Eun-Kyu Kim, Se Hyun Kim, Yu Jung Kim, Jee Hyun Kim, In Ah Kim, So Yeon Park
Purpose: Although microinvasive carcinoma is distinct from ductal carcinoma in situ (DCIS), the clinical significance of microinvasion in DCIS remains elusive. The purpose of this study is to evaluate the clinicopathological features and clinical outcomes of microinvasive carcinoma compared with pure DCIS. Methods: We assessed 613 cases of DCIS and microinvasive carcinoma that were consecutively resected from 2003 to 2014 and analyzed clinicopathological variables, expression of standard biomarkers such as the estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), p53, and Ki-67, and tumor recurrence...
June 2018: Journal of Breast Cancer
Soong June Bae, Jong Tae Park, Ah Young Park, Ji Hyun Youk, Jong Won Lim, Hak Woo Lee, Hak Min Lee, Sung Gwe Ahn, Eun Ju Son, Joon Jeong
Purpose: There is still a clinical need to easily evaluate the metastatic status of lymph nodes during breast cancer surgery. We hypothesized that ex vivo shear-wave elastography (SWE) would predict precisely the presence of metastasis in the excised lymph nodes. Methods: A total of 63 patients who underwent breast cancer surgery were prospectively enrolled in this study from May 2014 to April 2015. The excised axillary lymph nodes were examined using ex vivo SWE...
June 2018: Journal of Breast Cancer
Yongsik Jung, Soo Jung Lee, Juneyoung Lee, Woo Chul Noh, Seok Jin Nam, Byeong-Woo Park, Young Tae Bae, Sung-Soo Kang, Heung Kyu Park, Jung-Han Yoon, Je Ryong Kim, Se Hun Cho, Lee Su Kim, Byung In Moon, Sung Hoo Jung, Chol Wan Lim, Sung Yong Kim, Ho Yong Park, Jeongyoon Song, Kwang Man Lee, Sung Hwan Park, Joon Jeong, Hae Lin Park, Sung Won Kim, Beom Seok Kwak, Sun Hee Kang, Young Up Cho, Geum Hee Gwak, Yong Lae Park, Sang Wook Kim, Sehwan Han
Purpose: There are few reports from Asian countries about the long-term results of aromatase inhibitor adjuvant treatment for breast cancer. This observational study aimed to evaluate the long-term effects of letrozole in postmenopausal Korean women with operable breast cancer. Methods: Self-reported quality of life (QoL) scores were serially assessed for 3 years during adjuvant letrozole treatment using the Korean version of the Functional Assessment of Cancer Therapy-Breast questionnaires (version 3)...
June 2018: Journal of Breast Cancer
Isaac Kim, Hee Jun Choi, Jai Min Ryu, Se Kyung Lee, Jong Han Yu, Seok Won Kim, Seok Jin Nam, Jeong Eon Lee
Purpose: The American Joint Committee on Cancer (AJCC) recently released the breast cancer staging system, 8th edition, which included additional four biologic factors. However, there has been no external validation of the prognostic value of the new stages with different population-based databases. Methods: To validate the prognostic value of the new staging system in the Asian population, with a focus on Korean patients with breast cancer, we performed a retrospective study with data from the Korean Breast Cancer Society that included 24,014 patients with invasive ductal or lobular carcinoma who underwent surgery between January 2009 and January 2012 in Korea...
June 2018: Journal of Breast Cancer
Nirmala Dushyanthi Sirisena, Adebowale Adeyemo, Anchala Ishani Kuruppu, Nilakshi Samaranayake, Vajira Harshadeva Weerabaddana Dissanayake
Purpose: Several single nucleotide polymorphisms (SNPs) have been reported to be associated with clinicopathological profiles in sporadic breast cancer based on studies conducted on major population groups. The knowledge of the effects of these common genetic variants in South Asian populations remains limited. The present study aimed to investigate the association between a selected set of SNPs and the clinicopathological profiles in sporadic breast cancer in Sri Lankan women. Methods: A total of 350 postmenopausal women with histologically confirmed invasive breast cancer were genotyped for 58 SNPs located in 36 breast cancer related genes...
June 2018: Journal of Breast Cancer
Allison Kowalski, Catherine Woodstock Striley, Deepthi Satheesa Varma, Kathleen Marie Egan, Lusine Yaghjyan
Purpose: Alcohol consumption is associated with an increase in breast cancer risk, but findings on the association of alcohol with survival after breast cancer diagnosis have been inconsistent. Further, whether these associations could differ by adjuvant hormone therapy status is unknown. We examined interactions between alcohol consumption and adjuvant hormone therapy in relation to breast cancer-free survival among women with a primary breast cancer diagnosis. Methods: Participants in this study included 1,399 women diagnosed with primary breast cancer between 2007 and 2012 at the Moffitt Cancer Center...
June 2018: Journal of Breast Cancer
Man Li, Yang Wang, Feng Wei, Xiumei An, Naining Zhang, Shui Cao, Baozhu Ren, Xinwei Zhang, Xiubao Ren
Purpose: The treatment of triple-negative breast cancer (TNBC) remains challenging, due to the absence of estrogen, progesterone, and human epidermal growth factor receptors. This study was designed to evaluate the efficiency and safety of cytokine-induced killer (CIK) cell immunotherapy, following regular chemotherapy, for patients with TNBC. Methods: A total of 340 patients with postmastectomy TNBC, from January 1, 2010 to June 30, 2014, were included in this retrospective study...
June 2018: Journal of Breast Cancer
Qiannan Guo, Runyao Wen, Bin Shao, Yudong Li, Xin Jin, Heran Deng, Jiannan Wu, Fengxi Su, Fengyan Yu
Purpose: The long non-coding RNA H19 , a conservatively imprinted gene, acts as a molecular sponge for the let-7 family, which has been identified as a set of tumor suppressors. However, the combined prognostic value of H19 and let-7a signature in breast cancer patients remains unclear. Methods: In this research we assessed the prognostic value of the combined H19 and let-7a signature in breast cancer patients by retrospectively reviewing that data of 79 patients who underwent neoadjuvant chemotherapy; we also investigated the expression and function of H19 in breast cancer cell lines in vitro ...
June 2018: Journal of Breast Cancer
Ji Su Kim, Caspar Christian Haule, Joo Heung Kim, Sung Mook Lim, Kwang Hyun Yoon, Jee Ye Kim, Hyung Seok Park, Seho Park, Seung Il Kim, Young Up Cho, Byeong-Woo Park
Purpose: We investigated the changes in serum 25-hydroxyvitamin D (25[OH]D) levels before and after neoadjuvant chemotherapy (NCT) and the associations with pathologic complete response (pCR) and survival in patients with breast cancer. Methods: Serum 25(OH)D concentrations were measured pre- and post-NCT in 374 patients between 2010 and 2013. Based on a cutoff of 20 ng/mL, patients were categorized into "either sufficient" or "both deficient" groups...
June 2018: Journal of Breast Cancer
Yunxuan Wang, Tieying Dong, Qijia Xuan, Hong Zhao, Ling Qin, Qingyuan Zhang
Purpose: In this study, we aimed to evaluate lymphocyte-activation gene-3 (LAG-3) expression and its prognostic value in neoadjuvant-treated triple-negative breast cancer (TNBC). Methods: LAG-3, programmed death-1 (PD-1), programmed death ligand-1 (PD-L1), and CD8+ tumor-infiltrating lymphocyte (TILs) levels were examined using immunohistochemistry in 148 preand 114 post-neoadjuvant chemotherapy (NACT) specimens of human TNBC tissue. Correlations between expression levels and clinicopathological features were analyzed...
June 2018: Journal of Breast Cancer
Yunfei Zhao, Jiao He, Ling Yang, Qichi Luo, Zhi Liu
Purpose: The incidence and mortality of breast cancer is increasing worldwide. There is a constant quest to understand the underlying molecular biology of breast cancer so as to plan better treatment options. The purpose of the current study was to characterize the expression of histone deacetylases-3 (HDAC3), a member of class I HDACs, and assess the clinical significance of HDAC3 in breast cancer. Methods: Quantitative real-time polymerase chain reaction, immunohistochemistry, and western blot analysis were used to examine messenger RNA and protein expression levels...
June 2018: Journal of Breast Cancer
Fang-Min Zhou, Yun-Ying Huang, Tian Tian, Xiao-Yan Li, Yong-Bo Tang
Purpose: Chloride channel-3 (ClC-3) is a member of the chloride channel family and plays a critical role in a variety of cellular activities. The aim of the present study is to explore the molecular mechanisms underlying the antitumor effect of silencing ClC-3 in breast cancer. Methods: Human breast cancer cell lines MDA-MB-231 and MCF-7 were used in the experiments. Messenger RNA and protein expression were examined by quantitative real-time polymerase chain reaction and western blot analysis...
June 2018: Journal of Breast Cancer
Yuying Qi, Tinghui Hu, Kai Lin, Renqing Ye, Zuodong Ye
[This retracts the article on p. 218 in vol. 18, PMID: 26472971.].
March 2018: Journal of Breast Cancer
Yoshika Nagata, Manabu Yoshioka, Hidetaka Uramoto, Yosuke Tsurudome, Sohsuke Yamada, Takeshi Hanagiri, Fumihiro Tanaka
Malignant melanoma rarely originates from the female nipple. Tumors that develop on the skin of the breast are often subject to a delayed diagnosis. Cytologic examination provides excellent diagnostic capabilities and is a safe procedure with a lower risk of local implantation, compared to needle or incisional biopsy. We herein report a patient who underwent surgical resection of a primary malignant melanoma of the nipple. An elastic soft nodule was observed on the left nipple, and no abnormal lesions were identified in the breast...
March 2018: Journal of Breast Cancer
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