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Journal of Complementary & Integrative Medicine

Abdulrahman Khazim Al-Asmari, Abdul Quaiyoom Khan, Sarah A Al-Asmari, Abdulqadir Al-Rawi, Saud Al-Omani
BACKGROUND: Intestinal mucositis is a major concern related with cancer therapy. It is well established that overproduction of reactive oxygen species and inflammatory mediators plays vital role in the pathogenesis of mucositis. The aim of the study was to investigate the modulatory effect of vitamin E (vit. E) on 5-fluorouracil (5-FU)-induced intestinal mucositis by targeting oxidative stress and inflammatory markers in rats. METHODS: Rats were randomly divided into four groups of six animals each...
September 2, 2016: Journal of Complementary & Integrative Medicine
Ali Karimi, Mohammad-Taghi Moradi, Somayeh Alidadi, Leila Hashemi
BACKGROUND: Adenovirus (ADV) causes a number of diseases in human, and to date, no specific antiviral therapy is approved against this virus. Thus, searching for effective anti-ADV agents seems to be an urgent requirement. Many studies have shown that components derived from medicinal plants have antiviral activity. Therefore, the present study was aimed to evaluate in vitro anti-ADV activity and also antioxidant potential and total phenolic compounds of black tea (Camellia sinensis) crude extract...
August 30, 2016: Journal of Complementary & Integrative Medicine
Sangilimuthu Alagar Yadav, Sathishkumar Ramalingam, Anitha Jebamalairaj, Ravi Subban, Karpagavalli Mennakshi Sundaram
BACKGROUND: Antioxidant and antihistamine agents from Barleria noctiflora L.f. as natural source due to the existing modern medicine give various adverse effects to overcome these problems with natural products. METHODS: B. noctiflora leaves extract was fractionated with column chromatography; the homogenized fractions were monitored with thin layer chromatography (TLC) and characterized by using UV-visible, FT-IR, 1H NMR, 13C NMR and mass spectrometry spectral studies...
August 2, 2016: Journal of Complementary & Integrative Medicine
Askandar Tjokroprawiro, Sri Murtiwi, Raymond R Tjandrawinata
BACKGROUND: DLBS3233, a combined bioactive fraction of Cinnamomum burmanii and Lagerstroemia speciosa, has preclinically demonstrated its beneficial effects on glucose and lipid metabolism through the upregulation of insulin-signal transduction. This study evaluated the clinical efficacy of an add-on therapy with DLBS3233 in type-2 diabetes mellitus subjects inadequately controlled by metformin and other oral antidiabetes. METHODS: This was an open and prospective clinical study for 12 weeks of therapy, involving type-2 diabetes mellitus patients who had been treated with two oral antidiabetic agents for at least 3 months prior to screening, yet, with HbA1c level was still beyond 7...
July 23, 2016: Journal of Complementary & Integrative Medicine
Paul Joyce, Jon Wardle, Chris Zaslawski
BACKGROUND: This paper aims to remedy a gap in the knowledge by presenting the first critical review of the literature on major themes relating to medical students perceptions and attitudes towards the exponentially growing field of complementary and alternative medicine (CAM). METHODS: After a comprehensive database search of the literature, 21 papers were chosen as suitable for the review. The results from these papers were tabled and discussed. RESULTS: The results indicated that medical students lacked knowledge of CAM and are generally positive towards CAM education (especially in the preclinical years, if it provided evidence of efficacy and post-placement)...
July 23, 2016: Journal of Complementary & Integrative Medicine
Mirian Nnemdi Ashibuogwu, Olukayode Isaac Adeosun, Rufus Ojo Akomolafe, Douglas Olaniyi Sanni, Olaoluwa Sesan Olukiran
BACKGROUND: Cola nitida is a plant, conventionally used in Africa in the treatment of various ailments such as migraine, morning sickness and indigestion. The aim of the present study was to explore the diuretic activity of the aqueous extract of C. nitida seed (AECONS) and alteration caused by its subchronic administration on the structure and function of the kidney of male Wistar rats. METHODS: The study was divided into diuretic and subchronic studies. Twenty-five male Wistar rats weighing between 140 and 180 g were divided into five groups of five rats each...
July 14, 2016: Journal of Complementary & Integrative Medicine
Vandana Sanjeev Panda, Priyanka Mangesh Shinde
BACKGROUND: Spinacia oleracea known as spinach is a green-leafy vegetable consumed by people across the globe. It is reported to possess potent medicinal properties by virtue of its numerous antioxidant phytoconstituents, together termed as the natural antioxidant mixture (NAO). The present study compares the antacid effect of raw spinach juice with an antioxidant-rich methanolic extract of spinach (NAOE) in an artificial stomach model. METHODS: The pH of NAOE at various concentrations (50, 100 and 200 mg/mL) and its neutralizing effect on artificial gastric acid was determined and compared with that of raw spinach juice, water, the active control sodium bicarbonate (SB) and a marketed antacid preparation ENO...
July 12, 2016: Journal of Complementary & Integrative Medicine
Kate Templeman, Anske Robinson, Lisa McKenna
BACKGROUND: Improved teamwork between conventional and complementary medicine (CM) practitioners is indicated to achieve effective healthcare. However, little is known about interprofessional collaboration and education in the context of integrative medicine (IM). METHODS: This paper reports the findings from a constructivist-grounded theory method study that explored and highlighted Australian medical students' experiences and opportunities for linking interprofessional collaboration and learning in the context of IM...
July 12, 2016: Journal of Complementary & Integrative Medicine
Dominique Lanctôt, Gilles Dupuis, Roger Marcaurell, Annélie S Anestin, Madan Bali
BACKGROUND: Several cognitive behavioral interventions have been reported to reduce psychological symptoms in breast cancer (BC) patients. The goal of this study was to evaluate the effects of a yoga intervention in reducing depression and anxiety symptoms in BC patients. METHODS: This study was a randomized, partially blinded, controlled trial comparing a standardized yoga intervention to standard care. It was conducted at three medical centers in Montreal, Canada...
July 12, 2016: Journal of Complementary & Integrative Medicine
Sarah Mousavi, Alireza Ghannadi, Mohsen Meidani
BACKGROUND: Despite great advancement in treatment of sepsis, mortality of sepsis remains unacceptably high, even with the modern antibiotic and intensive care technologies. Considering the key role of immune dysfunction in sepsis pathophysiology, different treatments were evaluated, but failed to improve survival of patients. Natural remedies have been tested in various studies to overcome sepsis. In this study, we aim to review some of the evidence from clinical, in vitro and in vivo studies about the effect of alternative medicine on sepsis management...
July 9, 2016: Journal of Complementary & Integrative Medicine
Karishma Smart, Raymon Durso, Jonathan Morgan, Patrick McNamara
We present the case of a 78-year-old male who, 16 years ago, was diagnosed with Parkinson's disease (PD) by a neurologist. He initially presented with left-hand tremor, stooped posture, shuffling gait, and frequent falls, which eventually progressed to bilateral motor symptoms after 3 years. Since 2012, his symptoms and signs have almost completely remitted, and he has been off all pharmacotherapy for that time. The accuracy of the initial PD diagnosis is supported by an appropriate clinical presentation, history of positive response to Sinemet, and an abnormal SPECT DaT scan; thus this case suggests the possibility of remission of symptoms in some patients...
July 5, 2016: Journal of Complementary & Integrative Medicine
Joseph Adusei Sarkodie, Sylvia Afriyie Squire, Emelia Oppong Bekoe E, Charles Yaw Fosu Domozoro, Irene Awo Kretchy, Mariesta Kurukulasuriya Jayaroshini Ahiagbe, Samuel Frimpong-Manso S, Nana Akua Oboba Kwakyi, Dominic Adotei Edoh, Maxwel Sakyiama M, Vida Korkor Lamptey, Seigfried Affedzi-Obresi S, John Lee Duncan, Philip Debrah, Benoit Banga N'guessa, Julius Isaac Asiedu-Gyekye, Alexander Kwadwo Nyarko
BACKGROUND: The leaves of Pergularia daemia Forsk (family Asclepidaceae) provide alternative plant-based treatments for the management of diabetes mellitus and diarrhoea in both humans and indigenous poultry species like the Guinea fowls (Numida meleagris). However, no scientific investigations to validate its usefulness in Ghana have been established. This study therefore sought to investigate the anti-hyperglycaemic activity of the 70 % ethanolic extract of P. daemia using streptozotocin (STZ)-induced diabetic male Sprague-Dawley rats...
June 28, 2016: Journal of Complementary & Integrative Medicine
Rui Liu, Teresa W Tam, Jingqin Mao, Ammar Salem, John T Arnason, Anthony Krantis, Brian C Foster
BACKGROUND: Goji berry (Lycium barbarum) has been used as traditional Chinese medicine and a functional food in China. Goji tea may interact with drugs such as warfarin by inhibiting the cytochrome P450 (CYP) 2C9, and this study was undertaken to characterize the effect of Goji products on CYP2C9/19-, CYP2D6 *1/*10-, CYP3A4/5/7-, CYP19-, and flavin-containing monooxygenase (FMO) 3-mediated metabolism. METHODS: Goji juice, water, and ethanol extracts were examined for their effect on CYP2C9/19-, 2D6-, 3A4/5/7-, 4A11-, CYP19-, and FMO3-mediated metabolism by using in vitro bioassay...
June 28, 2016: Journal of Complementary & Integrative Medicine
Devanand Shanmugasundaram, Anand Duraiswamy, Arun Viswanathan, Changam Sheela Sasikumar, Sanjay M Cherian, Kotturathu Mammen Cherian
BACKGROUND: Polyherbalism, an alternative natural-based therapy for various disorders, has been quoted about 1,300 years before in Sharangdhar Samhita. Herbal-based combination therapy stages a vital role for the treatment of type 2 diabetes mellitus (T2DM) and associated complications. The present study aims at developing an Ayurvedic-based polyherbal formulation (ADPHF6) and the assessing its antidiabetic and antioxidant property. METHODS: ADPHF6 polyherbal formulation was measured for phytochemical components by qualitative methods...
June 28, 2016: Journal of Complementary & Integrative Medicine
Ginpreet Kaur, Mihir Invally, Meena Chintamaneni
BACKGROUND: Curcumin is a nutraceutical obtained from the rhizomes of Curcuma longa with a significant medicinal value against numerous disorders. However, the potential cannot be completely exploited due to low in vivo bioavailability. Hence, in order to enhance the bioavailability of curcumin, we combined it with the bioavailability enhancers like piperine and quercetin. METHODS: The present study was targeted to explore the antidiabetic potential of combinatorial extract of curcumin with piperine and quercetin (CPQ) in streptozotocin- and nicotinamide-induced diabetic rats...
June 25, 2016: Journal of Complementary & Integrative Medicine
Shivaji Chobe, Hemant Bhargav, Nagarathna Raghuram, Christoph Garner
BACKGROUND: Multiple sclerosis (MS) is characterized by a significant deterioration in auditory and visual reaction times along with associated depression and anxiety. Yoga and Physical therapy (PT) interventions have been found to enhance recovery from these problems in various neuropsychiatric illnesses, but sufficient evidence is lacking in chronic MS population. The aim of this study was to assess the effect of integrated Yoga and Physical therapy (IYP) on audiovisual reaction times, depression and anxiety in patients suffering from chronic MS...
June 23, 2016: Journal of Complementary & Integrative Medicine
Anupama R Valvi, Neelam Mouriya, Rajani B Athawale, Narendra S Bhatt
The liver plays vital functions in the maintenance and performance of the body. Most of the metabolic and physiological processes of our body as well as the detoxification of various drugs and xenobiotic chemicals occur in the liver. During this detoxification process, the reactive chemical intermediates damage the liver causing hepatotoxicity. Therefore, the maintenance of a healthy liver is vital to overall health. Unfortunately, the liver is often abused by environmental toxins, poor eating habits, alcohol, and prescription and over-the-counter drug use, which lead to liver diseases like hepatitis, non-alcoholic fatty liver disease, alcoholic liver disease, cirrhosis and hepatocellular carcinoma...
June 16, 2016: Journal of Complementary & Integrative Medicine
Ismail O Ishola, Olufunsho Awodele, Chinedum O Eluogu
BACKGROUND: Mangifera indica (Anacardiaceae) is an important herb in the traditional African and Ayurvedic medicines. The stem barks are used in the treatment of hypertension, insomnia, tumour, depression, rheumatism and as a tonic. This study was carried out to investigate antidepressant- and anxiolytic-like effect of the hydroethanol stem bark extract of M. indica (HeMI) in mice. METHODS: HeMI (12.5-100 mg/kg, p.o.) was administered 1 h before subjecting the animal to the forced swim test (FST), tail suspension test (TST) and elevated plus maze tests (EPM)...
June 8, 2016: Journal of Complementary & Integrative Medicine
Hugh A Semple, B Duff Sloley, José Cabanillas, Andrea Chiu, Steven K H Aung, Francis H Y Green
BACKGROUND: The purpose of these studies was to determine the safety of a botanical treatment for supporting healthy liver function developed in Peru. The formulation, A4+, contains extracts of Curcuma longa L. rhizome (A4R), Cordia lutea Lam. flower (A4F) and Annona muricata L. leaf (A4L). The tests were used to support an application for a non-traditional Natural Health Product Licence from the Natural Health Product Directorate of Health Canada and future clinical trials. METHODS: Besides reviewing the scientific and clinical information from Peru on the ingredients and conducting an initial Ames test for mutagenicity, we analysed A4+ for its chemical profile and tested genotoxicity (micronucleus test) and general toxicity (28-day repeated dose)...
June 1, 2016: Journal of Complementary & Integrative Medicine
Mohsen Mazidi, Maryam Shemshian, Seyed Hadi Mousavi, Abdolreza Norouzy, Tayebe Kermani, Toktam Moghiman, Akram Sadeghi, Naghme Mokhber, Majid Ghayour-Mobarhan, Gordon A A Ferns
BACKGROUND: Depression and anxiety are prevalent serious psychiatric disorders. Several drugs are used to treat these conditions but these are often associated with serious side effects. For this reason alternative therapies, including herbal medication such as saffron, have been proposed. We aimed to assess the effects of saffron extract for the treatment of anxiety and depression using a 12-week double-blind, placebo-controlled trial design. METHODS: Sixty adult patients with anxiety and depression were randomized to receive a 50 mg saffron capsule (Crocus sativus L...
June 1, 2016: Journal of Complementary & Integrative Medicine
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