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Journal of Complementary & Integrative Medicine

Heather Boon, Isabelle Gaboury, Lynda G Balneaves, Teresa Tsui, Jeremy Y Ng, Natalie Bozinovski
The following are abstracts of research presentations given at the 9th INCAM Research Symposium. The theme for this year's conference was "Expanding Person-Centred Care through Integrative Health Research", which was held on November 18 and 19, 2016 at the Toronto Marriott Bloor Yorkville Hotel in Ontario, Canada. The abstracts are grouped under the categories of oral or poster presentation based on their presentation at the Symposium. For more information, please visit:
October 26, 2016: Journal of Complementary & Integrative Medicine
Ali Karimi, Mohammad-Taghi Moradi, Somayeh Alidadi, Leila Hashemi
BackgroundAdenovirus (ADV) causes a number of diseases in human, and to date, no specific antiviral therapy is approved against this virus. Thus, searching for effective anti-ADV agents seems to be an urgent requirement. Many studies have shown that components derived from medicinal plants have antiviral activity. Therefore, the present study was aimed to evaluate in vitro anti-ADV activity and also antioxidant potential and total phenolic compounds of black tea (Camellia sinensis) crude extract. MethodsIn this study, the hydroalchoholic extract of black tea was prepared and its anti-ADV activity was evaluated on HEp2 cell line using MTT [3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide] assay...
December 1, 2016: Journal of Complementary & Integrative Medicine
Abdulrahman Khazim Al-Asmari, Abdul Quaiyoom Khan, Sarah A Al-Asmari, Abdulqadir Al-Rawi, Saud Al-Omani
BACKGROUND: Intestinal mucositis is a major concern related with cancer therapy. It is well established that overproduction of reactive oxygen species and inflammatory mediators plays vital role in the pathogenesis of mucositis. The aim of the study was to investigate the modulatory effect of vitamin E (vit. E) on 5-fluorouracil (5-FU)-induced intestinal mucositis by targeting oxidative stress and inflammatory markers in rats. METHODS: Rats were randomly divided into four groups of six animals each...
September 2, 2016: Journal of Complementary & Integrative Medicine
Karishma Smart, Raymon Durso, Jonathan Morgan, Patrick McNamara
We present the case of a 78-year-old male who, 16 years ago, was diagnosed with Parkinson's disease (PD) by a neurologist. He initially presented with left-hand tremor, stooped posture, shuffling gait, and frequent falls, which eventually progressed to bilateral motor symptoms after 3 years. Since 2012, his symptoms and signs have almost completely remitted, and he has been off all pharmacotherapy for that time. The accuracy of the initial PD diagnosis is supported by an appropriate clinical presentation, history of positive response to Sinemet, and an abnormal SPECT DaT scan; thus this case suggests the possibility of remission of symptoms in some patients...
September 1, 2016: Journal of Complementary & Integrative Medicine
Joseph Adusei Sarkodie, Sylvia Afriyie Squire, Emelia Oppong Bekoe, Charles Yaw Fosu Domozoro, Irene Awo Kretchy, Mariesta Kurukulasuriya Jayaroshini Ahiagbe, Samuel Frimpong-Manso, Nana Akua Oboba Kwakyi, Dominic Adotei Edoh, Maxwel Sakyiama, Vida Korkor Lamptey, Seigfried Affedzi-Obresi, John Lee Duncan, Philip Debrah, Benoit Banga N'guessa, Julius Isaac Asiedu-Gyekye, Alexander Kwadwo Nyarko
BACKGROUND: The leaves of Pergularia daemia Forsk (family Asclepidaceae) provide alternative plant-based treatments for the management of diabetes mellitus and diarrhoea in both humans and indigenous poultry species like the Guinea fowls (Numida meleagris). However, no scientific investigations to validate its usefulness in Ghana have been established. This study therefore sought to investigate the anti-hyperglycaemic activity of the 70 % ethanolic extract of P. daemia using streptozotocin (STZ)-induced diabetic male Sprague-Dawley rats...
September 1, 2016: Journal of Complementary & Integrative Medicine
Rui Liu, Teresa W Tam, Jingqin Mao, Ammar Salem, John T Arnason, Anthony Krantis, Brian C Foster
BACKGROUND: Goji berry (Lycium barbarum) has been used as traditional Chinese medicine and a functional food in China. Goji tea may interact with drugs such as warfarin by inhibiting the cytochrome P450 (CYP) 2C9, and this study was undertaken to characterize the effect of Goji products on CYP2C9/19-, CYP2D6 *1/*10-, CYP3A4/5/7-, CYP19-, and flavin-containing monooxygenase (FMO) 3-mediated metabolism. METHODS: Goji juice, water, and ethanol extracts were examined for their effect on CYP2C9/19-, 2D6-, 3A4/5/7-, 4A11-, CYP19-, and FMO3-mediated metabolism by using in vitro bioassay...
September 1, 2016: Journal of Complementary & Integrative Medicine
Devanand Shanmugasundaram, Anand Duraiswamy, Arun Viswanathan, Changam Sheela Sasikumar, Sanjay M Cherian, Kotturathu Mammen Cherian
BACKGROUND: Polyherbalism, an alternative natural-based therapy for various disorders, has been quoted about 1,300 years before in Sharangdhar Samhita. Herbal-based combination therapy stages a vital role for the treatment of type 2 diabetes mellitus (T2DM) and associated complications. The present study aims at developing an Ayurvedic-based polyherbal formulation (ADPHF6) and the assessing its antidiabetic and antioxidant property. METHODS: ADPHF6 polyherbal formulation was measured for phytochemical components by qualitative methods...
September 1, 2016: Journal of Complementary & Integrative Medicine
Ginpreet Kaur, Mihir Invally, Meena Chintamaneni
BACKGROUND: Curcumin is a nutraceutical obtained from the rhizomes of Curcuma longa with a significant medicinal value against numerous disorders. However, the potential cannot be completely exploited due to low in vivo bioavailability. Hence, in order to enhance the bioavailability of curcumin, we combined it with the bioavailability enhancers like piperine and quercetin. METHODS: The present study was targeted to explore the antidiabetic potential of combinatorial extract of curcumin with piperine and quercetin (CPQ) in streptozotocin- and nicotinamide-induced diabetic rats...
September 1, 2016: Journal of Complementary & Integrative Medicine
Shivaji Chobe, Hemant Bhargav, Nagarathna Raghuram, Christoph Garner
BACKGROUND: Multiple sclerosis (MS) is characterized by a significant deterioration in auditory and visual reaction times along with associated depression and anxiety. Yoga and Physical therapy (PT) interventions have been found to enhance recovery from these problems in various neuropsychiatric illnesses, but sufficient evidence is lacking in chronic MS population. The aim of this study was to assess the effect of integrated Yoga and Physical therapy (IYP) on audiovisual reaction times, depression and anxiety in patients suffering from chronic MS...
September 1, 2016: Journal of Complementary & Integrative Medicine
Anupama R Valvi, Neelam Mouriya, Rajani B Athawale, Narendra S Bhatt
The liver plays vital functions in the maintenance and performance of the body. Most of the metabolic and physiological processes of our body as well as the detoxification of various drugs and xenobiotic chemicals occur in the liver. During this detoxification process, the reactive chemical intermediates damage the liver causing hepatotoxicity. Therefore, the maintenance of a healthy liver is vital to overall health. Unfortunately, the liver is often abused by environmental toxins, poor eating habits, alcohol, and prescription and over-the-counter drug use, which lead to liver diseases like hepatitis, non-alcoholic fatty liver disease, alcoholic liver disease, cirrhosis and hepatocellular carcinoma...
September 1, 2016: Journal of Complementary & Integrative Medicine
Ismail O Ishola, Olufunsho Awodele, Chinedum O Eluogu
BACKGROUND: Mangifera indica (Anacardiaceae) is an important herb in the traditional African and Ayurvedic medicines. The stem barks are used in the treatment of hypertension, insomnia, tumour, depression, rheumatism and as a tonic. This study was carried out to investigate antidepressant- and anxiolytic-like effect of the hydroethanol stem bark extract of M. indica (HeMI) in mice. METHODS: HeMI (12.5-100 mg/kg, p.o.) was administered 1 h before subjecting the animal to the forced swim test (FST), tail suspension test (TST) and elevated plus maze tests (EPM)...
September 1, 2016: Journal of Complementary & Integrative Medicine
Olufunke M Mogbojuri, Adeolu A Adedapo, Matthew O Abatan
BACKGROUND: Sterculia tragacantha (Sterculiaceae) is used in the treatment of boils, diarrhea, dyspepsia, fever, gonorrhea, snake bite, syphilis, and tapeworm in some West African nations. This study is to investigate its anti-inflammatory and analgesic activities since the plant is being used to treat fever. METHODS: Fresh leaves of the plant were collected and dried at room temperature and pulverized into powder form and 200 g of this powder was dissolved first in hexane for 72 h and the extract was filtered and the filtrate was concentrated while the substrate was further dissolved in chloroform, ethyl acetate and methanol at different times and similar procedure adopted as for the hexane...
September 1, 2016: Journal of Complementary & Integrative Medicine
Afreen Usmani, Md Mujahid, Mohammad Khushtar, Hefazat H Siddiqui, Md Azizur Rahman
BACKGROUND: Traditional remedies employ herbal drugs for the treatment of liver ailments and hepatoprotection. Thus, the present study was designed to evaluate the hepatoprotective effect of "extract of Anacyclus pyrethrum Linn" (APE) against antitubercular drug-induced hepatotoxicity in rats. METHODS: Group I rats (normal control) received vehicle (1 % CMC), while group II rats (hepatotoxic control) isoniazid (INH) plus rifampicin (RIF) each 50 mg/kg/day po, for 28 days...
September 1, 2016: Journal of Complementary & Integrative Medicine
Pallavi Thakur, Raman Chawla, Alka Narula, Rajeev Goel, Rajesh Arora, Rakesh Kumar Sharma
BACKGROUND: Berberis aristata is known to contain a variety of phenolic compounds, flavonoids such as quercetin attributing towards its holistic capability of mitigating multidrug resistance. METHODS: B. aristata stem bark extract was prepared and characterized using phytochemical and bioactivity-based fingerprinting. Anti-oxidant and anti-lipid peroxidation profiling was also done in conjunction with in vitro anti-microbial efficacy testing against the test microorganism i...
September 1, 2016: Journal of Complementary & Integrative Medicine
Olufunke Ola-Davies, O Samuel Ajani
BACKGROUND: Sodium arsenite has been proven to be abundant in nature and released into the environment through human activities, including agricultural and industrial processes. The objective of our study was to investigate the sperm protective potential of Pistia stratiotes Linn. in arsenic-treated rats. METHODS: The sperm protective potential of P. stratiotes Linn. (Araceae) was carried out in arsenic-exposed rats using 24 male albino rats (225 to 228 g) aged between 14 and 16 weeks old...
September 1, 2016: Journal of Complementary & Integrative Medicine
Sanjay Mohan Gupta, Kamal Kumar
In the present opinion paper, we have been introducing for the first time the stinging plants and/or their biological toxins as novel bio-threat agents that may be used for the development of bio-weapons for self-defence purpose. The selected studied stinging plants are having dual role as nutraceutical and ethno-pharmacological uses apart from their less explored stinging property. However, future detailed work is required for identification and characterization of the precise stinging chemical components that will be used for the formulation of novel bio-warfare agents for self-defence purpose...
September 1, 2016: Journal of Complementary & Integrative Medicine
Sangilimuthu Alagar Yadav, Sathishkumar Ramalingam, Anitha Jebamalairaj, Ravi Subban, Karpagavalli Mennakshi Sundaram
BACKGROUND: Antioxidant and antihistamine agents from Barleria noctiflora L.f. as natural source due to the existing modern medicine give various adverse effects to overcome these problems with natural products. METHODS: B. noctiflora leaves extract was fractionated with column chromatography; the homogenized fractions were monitored with thin layer chromatography (TLC) and characterized by using UV-visible, FT-IR, 1H NMR, 13C NMR and mass spectrometry spectral studies...
August 2, 2016: Journal of Complementary & Integrative Medicine
Askandar Tjokroprawiro, Sri Murtiwi, Raymond R Tjandrawinata
BACKGROUND: DLBS3233, a combined bioactive fraction of Cinnamomum burmanii and Lagerstroemia speciosa, has preclinically demonstrated its beneficial effects on glucose and lipid metabolism through the upregulation of insulin-signal transduction. This study evaluated the clinical efficacy of an add-on therapy with DLBS3233 in type-2 diabetes mellitus subjects inadequately controlled by metformin and other oral antidiabetes. METHODS: This was an open and prospective clinical study for 12 weeks of therapy, involving type-2 diabetes mellitus patients who had been treated with two oral antidiabetic agents for at least 3 months prior to screening, yet, with HbA1c level was still beyond 7...
July 23, 2016: Journal of Complementary & Integrative Medicine
Paul Joyce, Jon Wardle, Chris Zaslawski
BACKGROUND: This paper aims to remedy a gap in the knowledge by presenting the first critical review of the literature on major themes relating to medical students perceptions and attitudes towards the exponentially growing field of complementary and alternative medicine (CAM). METHODS: After a comprehensive database search of the literature, 21 papers were chosen as suitable for the review. The results from these papers were tabled and discussed. RESULTS: The results indicated that medical students lacked knowledge of CAM and are generally positive towards CAM education (especially in the preclinical years, if it provided evidence of efficacy and post-placement)...
July 23, 2016: Journal of Complementary & Integrative Medicine
Mirian Nnemdi Ashibuogwu, Olukayode Isaac Adeosun, Rufus Ojo Akomolafe, Douglas Olaniyi Sanni, Olaoluwa Sesan Olukiran
BACKGROUND: Cola nitida is a plant, conventionally used in Africa in the treatment of various ailments such as migraine, morning sickness and indigestion. The aim of the present study was to explore the diuretic activity of the aqueous extract of C. nitida seed (AECONS) and alteration caused by its subchronic administration on the structure and function of the kidney of male Wistar rats. METHODS: The study was divided into diuretic and subchronic studies. Twenty-five male Wistar rats weighing between 140 and 180 g were divided into five groups of five rats each...
July 14, 2016: Journal of Complementary & Integrative Medicine
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