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ACS Nano

Christopher Hoyle, Jack Rivers-Auty, Eloïse Lemarchand, Sandra Vranic, Emily Wang, Maurizio Buggio, Nancy J Rothwell, Stuart M Allan, Kostas Kostarelos, David Brough
Graphene oxide (GO), an oxidized form of graphene, has potential applications in biomedical research. However, how GO interacts with biological systems, including the innate immune system, is poorly understood. Here we elucidate the effects of GO sheets on macrophages, identifying distinctive effects of GO on inflammatory phenotype. Small, thin (s) GO dose-dependently inhibited release of interleukin (IL)-1β and IL-6, but not tumor necrosis factor (TNF)-α. NLRP3 inflammasome and caspase 1 activation was not affected...
November 16, 2018: ACS Nano
Zhouyue Lei, Peiyi Wu
With growing interests in the fields of wearable devices, it is crucial yet rather challenging to develop skin-like soft conductive materials with customizable functionalities and human tissue-compatible mechanical properties. Previously-reported electronic skins struggle to meet the demands for transparence, mechanical adaptability and stable conductivity during deformation. The recent rise of ionic skins with inorganic salts or ionic liquids doping provides the intrinsic stretchability, however, dilemmas remain for their limited functionalities such as a monotonous appearance and a narrow scope of mechanical and sensory properties...
November 16, 2018: ACS Nano
Peter M Aldridge, Monorina Mukhopadhyay, Sharif U Ahmed, Wendi Zhou, Elisa Christinck, Rhema Makonnen, Edward H Sargent, Shana O Kelley
The analysis of heterogeneous subpopulations of circulating tumor cells (CTCs) is critical to enhance our understanding of cancer metastasis and enable non-invasive cancer diagnosis and monitoring. The phenotypic variability and plasticity of these cells - properties closely linked to their clinical behavior - demand techniques that isolate viable, discrete fractions of tumor cells for functional assays of their behavior and detailed analysis of biochemical properties. Here, we introduce the Prism Chip, a high-resolution immunomagnetic profiling and separation chip which harnesses a cobalt-based alloy to separate a flowing stream of nanoparticle-bound tumor cells with differential magnetic loading into ten discrete streams...
November 16, 2018: ACS Nano
Guanjun Deng, Zhihong Sun, Sanpeng Li, Xinghua Peng, Wenjun Li, Lihua Zhou, Yifan Ma, Ping Gong, Lintao Cai
Developing effective immunotherapies with low toxicity and high tumor specificity is the ultimate goal in the battle against cancer. Here, we reported a cell-membranes immunotherapy strategy that was able to eliminate primary tumors and inhibited distant tumors by using NK cell-membranes-cloaked photosensitizer TCPP-loaded nanoparticles (NK-NPs). Proteomic profiling of NK cell-membranes was performed through shotgun proteomics, and we found that NK cell-membranes enabled the NK-NPs to target tumors and could induce or enhance pro-inflammatory M1-macrophages polarization to produce antitumor immunity...
November 16, 2018: ACS Nano
Huijun Phoebe Tham, Keming Xu, Wei Qi Lim, Hongzhong Chen, Mengjia Zheng, Tien Guan Steven Thng, Subramanian S Venkatraman, Chenjie Xu, Yanli Zhao
Topical treatment using photodynamic therapy (PDT) for many types of skin cancers has largely been limited by the inability of existing photosensitizers to penetrate into the deep skin tissue. To overcome these problems, we developed a mesoporous nanovehicle with dual loading of photosensitizers and clinically relevant drugs for combination therapy, while utilizing microneedle technology to facilitate their penetration into deep skin tissue. Sub-50 nm photodynamically active mesoporous organosilica nanoparticles were synthesized with photosensitizers covalently bonded to the silica matrix, which dramatically increased the quantum yield and photostability of these photosensitizers...
November 16, 2018: ACS Nano
Marianna Colasuonno, Anna Lisa Palange, Rachida Aid, Miguel Ferreira, Hilaria Mollica, Roberto Palomba, Michele Emdin, Massimo Del Sette, Cédric Chauvierre, Didier Letourneur, Paolo Decuzzi
Tissue plasminogen activator (tPA) is the sole approved therapeutic molecule for the treatment of acute ischemic stroke. Yet, only a small percentage of patients could benefit from this life-saving treatment because of medical contraindications and severe side effects, including brain hemorrhage, associated with delayed administration. Here, a nano therapeutic agent is realized by directly associating the clinical formulation of tPA to the porous structure of soft discoidal polymeric nanoconstructs (tPA-DPNs)...
November 16, 2018: ACS Nano
Peng Si, Edwin Yuan, Orly Liba, Yonatan Winetraub, Siavash Yousefi, Elliott Daniel SoRelle, Derek William Yecies, Rebecca Dutta, Adam de la Zerda
Optical coherence tomography angiography (OCTA) is an important tool for investigating vascular networks and microcirculation in living tissue. Traditional OCTA detects blood vessels via intravascular dynamic scattering signals derived from the movements of red blood cells (RBCs). However, the low hematocrit and long latency between RBCs in capillaries make these OCTA signals discontinuous, leading to incomplete mapping of the vascular networks. OCTA imaging of microvascular circulation is particularly challenging in tumors due to the abnormally slow blood flow in angiogenic tumor vessels and strong attenuation of light by tumor tissue...
November 16, 2018: ACS Nano
Jaewon Lee, Elias Nakouzi, Miao Song, Bin Wang, Jaehun Chun, Dongsheng Li
Superlattice structures formed by nanoparticle (NP) self-assembly have attracted increasing attention due to their potential as a class of nanomaterials with enhanced physicochemical properties tailored by the assembly structure. However, many key questions remain regarding the correlation between the dynamics of individual NPs and emerging superlattice patterns. Here we investigated the self-assembly of gold NPs by employing in situ transmission electron microscopy equipped with direct detection camera capabilities, which enabled us to track the rapid motion of individual nanoparticles in real time...
November 16, 2018: ACS Nano
Weitao Yang, Xiudong Shi, Yuxin Shi, Defan Yao, Shizhen Chen, Xin Zhou, Bingbo Zhang
Protein-assisted biomimetic synthesis has been an emerging offshoot of nanofabrication in recent years owing to its features of green chemistry, facile process, and ease of multi-integration. As a result, many proteins have been used for biomimetic synthesis of varying kinds of nanostructures. Although the efforts on exploring new proteins and investigating their roles in biomimetic chemistry are increasing, the most essential intrinsic properties of proteins are largely neglected. Herein we report a frequently used enzyme (horseradish peroxidase, HRP) to demonstrate the possibility of enzymatic activity retaining after accomplishing the roles in biomimetic synthesis of ultrasmall gadolinium (Gd) nanodots and stowing its substrate 2,2'-Azinobis (3-ethylbenzothiazoline-6-sulfonic acid ammonium salt) (ABTS), denoted as Gd@HRPABTS ...
November 16, 2018: ACS Nano
Bowen Li, Zhefan Yuan, Patrick McMullen, Jingyi Xie, Priyesh Jain, Hsiang-Chieh Hung, Shihan Xu, Peng Zhang, Xiaojie Lin, Kan Wu, Shaoyi Jiang
The undesirable immune response poses a life-threatening challenge to human health. It not only deteriorates the therapeutic performance of biologic drugs but also contributes to various diseases such as allergies and autoimmune diseases. Inspired by the role of chromatin in the maintenance of natural immune tolerance, here we report a DNA-protein polymeric nanocomplex that can mimic the tolerogenic function of chromatin and induce an immune tolerance to its protein cargos. We first proved that the chromatin-mimetic nanomedicine loaded with keyhole limpet hemocyanin (KLH), a highly immunogenic model protein, could elicit a durable antigen-specific immune tolerance to KLH lasting for at least five weeks in mice...
November 16, 2018: ACS Nano
Hossein Taghinejad, Daniel A Rehn, Christine Muccianti, Ali A Eftekhar, Mengkun Tian, Tianren Fan, Xiang Zhang, Yuze Meng, Yanwen Chen, Tran-Vinh Nguyen, Sufei Shi, Pulickel M Ajayan, John Schaibley, Evan J Reed, Ali Adibi
Alloying plays a central role in tailoring the material properties of 2D transition-metal dichalcogenides (TMDs). However, despite widespread reports, the details of the alloying mechanism in 2D TMDs have remained largely unknown and yet to be further explored. Here, we combine a set of systematic experiments with ab-initio density-functional theory (DFT) calculations to unravel a defect-mediated mechanism for the alloying of monolayer TMD crystals. In our alloying approach, a monolayer MoSe2 film serves as a host crystal in which exchanging selenium (Se) atoms with sulfur (S) atoms yields a MoS2xSe2(1-x) alloy...
November 15, 2018: ACS Nano
Chao Yin, Guohua Wen, Chao Liu, Boguang Yang, Sien Lin, Jiawei Huang, Pengchao Zhao, Siu Hong Dexter Wong, Kunyu Zhang, Xiaoyu Chen, Gang Li, Xiaohua Jiang, Jianping Huang, Kanyi Pu, Lidai Wang, Liming Bian
Photoacoustic (PA) imaging and tracking of stem cells plays an important role in the real-time assessment of cell-based therapies. Nevertheless, the limitations of conventional inorganic PA contrast agents and the narrow range of the excitation wavelength in the first near-infrared (NIR-I) window hamper the applications of PA imaging in living subjects. Herein we report the design and synthesis of a second near-infrared (NIR-II) absorptive organic semiconducting polymer (OSP)-based nanoprobe (OSPN+) for PA imaging and tracking of stem cells...
November 15, 2018: ACS Nano
Sori Lee, Gyoyeon Hwang, Tae Hee Kim, S Joon Kwon, Jong Uk Kim, Kyongbeom Koh, Byeonghak Park, Haeleen Hong, Ki Jun Yu, Heeyeop Chae, Youngmee Jung, Jiyeon Lee, Tae-Il Kim
No abstract text is available yet for this article.
November 15, 2018: ACS Nano
Zhichao Liu, Hao Pei, Limin Zhang, Yang Tian
Herein, a single highly selective DNA nanoprobe was designed and created for the real-time imaging and simultaneous quantification of two kinds of biological species using Ca2+ and pH; the molecules were selected as models because of their close relationship with cellular functions and diseases. A Ca2+ fluorescent probe was synthesized and assembled onto a DNA nanostructure together with pH-responsive, inner-reference, and mitochondria-targeted molecules. This nanoprobe with high spatial resolution, together with long-term fluorescent and structural stability, powerfully tracked pH and Ca2+ dynamics at the same localization in mitochondria in response to O2 •- -induced oxidative stress and aggregated amyloid β (Aβ) stimulation with a temporal resolution of milliseconds...
November 15, 2018: ACS Nano
Wei Tang, Wenpei Fan, Zhantong Wang, Weizhong Zhang, Shiyi Zhou, Yijing Liu, Zhen Yang, Emily Shao, Guofeng Zhang, Orit Jacobson, Lingling Shan, Rui Tian, Siyuan Cheng, Lisen Lin, Yulun Dai, Zheyu Shen, Gang Niu, Jin Xie, Xiaoyuan Chen
Featured with a large surface area, uniform interpenetrating mesopores, diverse organic framework hybridization, and well-defined surface properties, the hollow mesoporous organosilica nanoparticle (HMON) represents a promising paradigm in drug delivery systems with excellent biocompatibility. However, effective tumor accumulation and precise cancer theranostics of the HMON still remain a challenge. In this study, an "ammonia-assisted hot water etching" method is applied for the successful construction of sub-50 nm thioether/phenylene dual-hybridized HMON with low hemolytic effect...
November 15, 2018: ACS Nano
Dajie Zhang, Jie Liu, Bo Chen, Yong Zhao, Jingxia Wang, Tomiki Ikeda, Lei Jiang
Janus/gradient actuating materials have become promising candidates for actuating devices. The fabrication of functional Janus gradient actuators remains a challenge. This paper presents a facile fabrication of a hydrophilic/hydrophobic Janus inverse opal actuator via gradient infiltration. The Janus characteristics of the fabricated actuator were attributed to gradient infiltration along the thickness of the film caused by the gradient light intensity and the distinct polymerization behavior of ionic liquids and methyl methacrylate in the methanol system...
November 15, 2018: ACS Nano
Ziying Wang, Yi-Yang Sun, Ibrahim Abdelwahab, Liang Cao, Wei Yu, Huanxin Ju, Junfa Zhu, Wei Fu, Leiqiang Chu, Hai Xu, Kian Ping Loh
Controlling superconducting phase transition on a two-dimensional (2D) material is of great fundamental and technological interest from the viewpoint of making 2D resistance-free electronic circuits. Here, we demonstrate that a 1 T-to-2 H phase transition can be induced on the topmost monolayer of bulk (<100 nm thick) 1 T-TaS2 by thermal annealing. The monolayer 2 H-TaS2 on bulk 1 T-TaS2 exhibits a superconducting transition temperature ( Tc ) of 2.1 K, which is significantly enhanced compared to that of bulk 2 H-TaS2 ...
November 15, 2018: ACS Nano
Samia Ouhajji, Bas G P van Ravensteijn, Carla Fernandez-Rico, Kanvaly S Lacina, Albert P Philipse, Andrei V Petukhov
We disclose a method for the synthesis of chiral colloids from spontaneously formed hollow sugar-surfactant microtubes with internally confined mobile colloidal spheres. Key feature of our approach is the grafting of colloid surfaces with photo-responsive coumarin moieties, which allow for UV-induced, covalent clicking of colloids into permanent chains, with morphologies set by the colloid-to-tube diameter ratio. Subsequent dissolution of tube confinement yields aqueous suspensions that comprise bulk quantities of a variety of linear chains, including single helical chains of polystyrene colloids...
November 14, 2018: ACS Nano
Yuan Gao, Baoxing Xu
Programming thermal transport across interfaces by engineering strain is of critical importance for exploring mechanical controllable and thermal manageable devices with multifunctionalities. Here, we report a van der Waals heterostructure that is composed of bilayer graphene kirigami with diverse layer cut patterns and assembly organizations and show that the thermal flow intensity across the van der Waals interfaces, named as thermal transparency, could be continuously regulated by applying an external in-plane tensile strain...
November 14, 2018: ACS Nano
Pan Xiong, Xiuyun Zhang, Fan Zhang, Ding Yi, Jinqiang Zhang, Bing Sun, Huajun Tian, Devaraj Shanmukaraj, Teófilo Rojo, Michel Armand, Renzhi Ma, Takayoshi Sasaki, Guoxiu Wang
Cation-deficient two-dimensional (2D) materials, especially atomically thin nanosheets are highly promising electrode materials for electrochemical energy storage that undergo metal ion-insertion reactions, yet have rarely been achieved thus far. Here, we report a Ti-deficient 2D unilamellar lepidocrocite-type titanium oxide (Ti0.87O2) nanosheet superlattice for sodium storage. The superlattice composed of alternately restacked defective Ti0.87O2 and nitrogen-doped graphene monolayers exhibits an outstanding capacity of ~490 mA h g-1 at 0...
November 14, 2018: ACS Nano
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