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ACS Nano

Wenfei Chen, Ying Wang, Ming Qin, Xudong Zhang, Zhirong Zhang, Xun Sun, Zhen Gu
The facultative anaerobe Salmonella strain VNP20009 selectively colonizes into tumors following systemic injection due to its preference for the hypoxia in the tumor cores. However, the Phase 1 Clinical Trial of VNP20009 has been terminated mainly due to its weak anti-tumor effects and exhibition of dose-dependent toxicity. Here we leveraged the advantages of VNP20009 biotherapy together with polydopamine-mediated photothermal therapy in order to enhance the antitumor efficacy toward malignant melanoma. VNP20009 was coated with polydopamine via oxidation and self-polymerization, which was then injected into tumor-bearing mice via the tail vein...
May 22, 2018: ACS Nano
Andrij Vasylenko, Samuel Marks, Jamie M Wynn, Paulo V C Medeiros, Quentin M Ramasse, Andrew J Morris, Jeremy Sloan, David Quigley
Nanostructuring, e.g. reduction of dimensionality in materials offers a viable route towards regulation of materials electronic and hence functional properties. Here, we present the extreme case of nanostructuring, exploiting capillarity of single-walled carbon nanotubes (SWCNTs) for synthesis of the smallest possible SnTe nanowires with cross sections as small as a single atom column. We demonstrate that by choosing the appropriate diameter of a template SWCNT, we can manipulate the structure of the quasi-one-dimensional (1D) SnTe and to design electronic behaviour...
May 21, 2018: ACS Nano
Debarghya Sarkar, Wei Wang, Matthew Mecklenburg, Andrew J Clough, Matthew Yeung, Chenhao Ren, Qingfeng Lin, Louis Blankemeier, Shanyuan Niu, Huan Zhao, Haotian Shi, Han Wang, Stephen B Cronin, Jayakanth Ravichandran, Mitul Luhar, Rehan Kapadia
The growth of crystalline compound semiconductors on amorphous and non-epitaxial substrates is a fundamental challenge for state-of-the-art thin-film epitaxial growth techniques. Direct growth of materials on technologically relevant amorphous surfaces, such as nitrides or oxides results in nanocrystalline thin-films, or nanowire type structures, preventing growth and integration of high-performance devices and circuits on these surfaces. Here we show crystalline compound semiconductors grown directly on technologically relevant amorphous and non-epitaxial substrates in geometries compatible with standard microfabrication technology...
May 18, 2018: ACS Nano
Avishek Dey, Satheesh Krishnamurthy, James Bowen, Dennis Nordlund, M Meyyappan, Ram P Gandhiraman
Miniaturisation of electronic devices and the advancement of Internet of things pose exciting challenges to develop technologies for patterned deposition of functional nanomaterials. Printed and flexible electronic devices and energy storage devices can be embedded onto clothing or other flexible surfaces. Graphene oxide (GO) has gained much attention in printed electronics due its solution processability, robustness and high electrical conductivity in the reduced state. Here we introduce a new approach to print GO films from highly acidic suspensions with in-situ reduction using an atmospheric pressure plasma jet...
May 18, 2018: ACS Nano
Dwaipayan Ghosh, Benny Febriansyah, Disha Gupta, Leonard Kia-Sheun Ng, Shibo Xi, Yonghua Du, Tom Baikie, ZhiLi Dong, Han Sen Soo
Catalyst deactivation is a persistent problem not only for the scientific community but also in industry. Isolated single-site heterogeneous catalysts have shown great promise to overcome these problems. Here, a versatile anchoring strategy for molecular complex immobilization on a broad range of semiconducting or insulating metal oxide (e.g. titanium dioxide, mesoporous silica, cerium oxide, and tungsten oxide) nanoparticles to synthesize isolated single-site catalysts has been studied systematically. An oxidatively stable anchoring group, maleimide, is shown to form covalent linkages with surface hydroxyl functionalities of metal oxide nanoparticles by photoclick chemistry...
May 18, 2018: ACS Nano
Christian Bortolini, Lasse Hyldgaard Klausen, Søren Vrønning Hoffmann, Nykola C Jones, Daniela Saadeh, Zegao Wang, Tuomas P J Knowles, Mingdong Dong
Aberrant assembly of the amyloid-β (Aβ) is responsible for the development of Alzheimer's disease, but can also be exploited to obtain highly functional biomaterials. The short Aβ fragment, KLVFF (Aβ16-20), is crucial for Aβ assembly and considered to be an Aβ aggregation inhibitor. Here, we show that acetylation of KLVFF turns it into an extremely fast self-assembling molecule, reaching macroscopic (i.e. mm) size in seconds. We show that KLVFF is metastable and that the self-assembly can be directed towards a crystalline or fibrillar phase simply through chemical modification, via acetylation or amidation of the peptide...
May 17, 2018: ACS Nano
Ran Cao, Xianjie Pu, Xinyu Du, Wei Yang, Jiaona Wang, Hengyu Guo, Shuyu Zhao, Zuqing Yuan, Chi Zhang, Congju Li, Zhong Lin Wang
Electronic textile (E-textile) with designable electric circuit and multi-functionalities holds great application prospect for future wearable electronics. However, most of the E-textiles still have critical challenges, including air permeability, satisfactory washability and massive fabrication. In this work, we fabricate a washable E-textile that addresses all of the concerns and show its application as a self-powered triboelectric gesture textile for intelligent human-machine interface. Utilizing conductive carbon nanotubes (CNTs) and screen-printing technology, this kind of E-textile embraces high conductivity (0...
May 17, 2018: ACS Nano
Jon Gorecki, Vasilis Apostolopoulos, Jun-Yu Ou, Sakellaris Mailis, Nikitas Papasimakis
We demonstrate experimentally non-volatile, all-optical control of graphene's charge transport properties by virtue of a Fe:LiNbO3 photoconductive substrate. The substrate can register and sustain photo-induced charge distributions which modify locally the electrostatic environment of the graphene monolayer and allow spatial control of graphene resistivity. We present light-induced changes of graphene sheet resistivity as high as ∼370 Ω/sq (~ 2.6 fold increase) under spatially non-uniform light illumination...
May 17, 2018: ACS Nano
Rong Yang, Jun Xu, Ligeng Xu, Xiaoqi Sun, Qian Chen, Yuhuan Zhao, Rui Peng, Zhuang Liu
Tumor vaccines for cancer prevention and treatment have attracted tremendous interests in the area of cancer immunotherapy in recent years. In this work, we present a strategy to construct cancer vaccines by encapsulating immune-adjuvant nanoparticles with cancer cell membrane modified by mannose. Poly (D, L-lactide-co-glycolide) (PLGA) nanoparticles are firstly loaded with toll-like receptor 7 agonist, imiquimod (R837). Those adjuvant nanoparticles (NP-R) are then coated with cancer cell membranes (NP-R@M), whose surface proteins could act as tumor-specific antigens...
May 17, 2018: ACS Nano
Dandan Zhao, Yecan Pi, Qi Shao, Yonggang Feng, Ying Zhang, Xiaoqing Huang
The development of electrocatalysts with high activity and stability for oxygen evolution reaction (OER) is critically important, the one being regarded as the bottleneck process of overall water splitting. Herein, we fulfill significant OER improvement in both activity and stability by constructing a class of Ni(OH)2 -CeO2 supported on carbon paper (Ni x Ce y @CP) with an intimate hydroxide (Ni(OH)2 )-oxide (CeO2 ) interface. Such interface largely promotes the OER activity with a low overpotential of 220 mV at 10 mA cm-2 and a small Tafel slope of 81...
May 17, 2018: ACS Nano
Ruocun Wang, James B Mitchell, Qiang Gao, Wan-Yu Tsai, Shelby Boyd, Matt Pharr, Nina Balke, Veronica Augustyn
The presence of structural water in tungsten oxides leads to a transition in the energy storage mechanism from battery-type intercalation (limited by solid state diffusion) to pseudocapacitance (limited by surface kinetics). Here, we demonstrate that these electrochemical mechanisms are linked to the mechanical response of the materials during intercalation of protons, and present a pathway to utilize the mechanical coupling for local studies of electrochemistry. Operando atomic force microscopy (AFM) dilatometry is used to measure the deformation of redox-active energy storage materials, and to link the local nanoscale deformation to the electrochemical redox-process...
May 16, 2018: ACS Nano
Diane M Haiber, Peter A Crozier
In graphitic carbon nitrides, (photo)catalytic functionality is underpinned by the effect that residual hydrogen content, manifesting in amine (N-Hx ) defects, has on its optoelectronic properties. Therefore, a detailed understanding of the variation in the local structure of graphitic carbon nitrides is key for understanding structure-activity relationships. Here we apply aloof-beam vibrational electron energy-loss spectroscopy in the scanning transmission electron microscope (STEM) to locally detect variations in hydrogen content in two different layered carbon nitrides with nanometer resolution...
May 16, 2018: ACS Nano
Timothy Ellis, Michele Chiappi, Andres Garcia-Trenco, Maryam Al-Ejji, Srijata Sarkar, Theoni K Georgiou, Milo Sebastian Peter Shaffer, Teresa D Tetley, Stephan Schwander, Mary P Ryan, Alexandra E Porter
Mycobacterium tuberculosis (M.tb) has the extraordinary ability to adapt to the administration of antibiotics through the development of resistance mechanisms. By rapidly exporting drugs from within the cytosol, these pathogenic bacteria diminish antibiotic potency and drive the presentation of drug tolerant tuberculosis (TB). The membrane integrity of M.tb is pivotal in retaining these drug-resistant traits. Silver (Ag) and zinc oxide (ZnO) nanoparticles (NPs) are established antimicrobial agents that effectively compromise membrane stability, giving rise to increased bacterial permeability to antibiotics...
May 16, 2018: ACS Nano
Heemin Kang, Hee Joon Jung, Sung Kyu Kim, Dexter Siu Hong Wong, Sien Lin, Gang Li, Vinayak P Dravid, Liming Bian
Macrophages are key immune cells that perform various physiological functions, such as the maintenance of homeostasis, host defense, disease progression, and tissue regeneration. Macrophages adopt distinctly polarized phenotypes, such as pro-inflammatory M1 phenotype or anti-inflammatory (pro-healing) M2 phenotype, to execute disparate functions. The remotely controlled reversible uncaging of bioactive ligands, such as Arg-Gly-Asp (RGD) peptide, is an appealing approach for temporally regulating the adhesion and resultant polarization of macrophages on the implants in vivo...
May 16, 2018: ACS Nano
Christian Dahl-Petersen, Manuel Sarić, Michael Brorson, Poul Georg Moses, Jan Rossmeisl, Jeppe V Lauritsen, Stig Helveg
Layered transition metal dichalcogenides have distinct physicochemical properties at their edge-terminations. The production of an abundant density of edge structures is, however, impeded by the excess surface energy of edges compared to basal planes and would benefit from insight into the atomic growth mechanisms. Here, we show that edge-terminated MoS2 nanostructures can form during sulfidation of MoO2 nanocrystals by using in situ transmission electron microscopy (TEM). Time-resolved TEM image series reveal that the MoO2 surface can sulfide by inward progression of MoO2 (20-2):MoS2 (002) interfaces resulting in upright-oriented and edge-exposing MoS2 sheets...
May 16, 2018: ACS Nano
Mohamed Shehata Draz, Nivethitha Kota Lakshminaraasimulu, Sanchana Krishnakumar, Dheerendranath Battalapalli, Anish Vasan, Manoj Kumar Kanakasabapathy, Aparna Sreeram, Shantanu Kallakuri, Prudhvi Thirumalaraju, Yudong Li, Stephane Hua, Xu G Yu, Daniel R Kuritzkes, Hadi Shafiee
Zika virus (ZIKV) infection is an emerging pandemic threat to humans that can be fatal in newborns. Advances in digital health systems and nanoparticles can facilitate the development of sensitive and portable detection technologies for timely management of emerging viral infections. Here we report a nanomotor-based bead-motion cellphone (NBC) system for the immunological detection of ZIKV. The presence of virus in a testing sample results in the accumulation of platinum (Pt)-nanomotors on the surface of beads, causing their motion in H2 O2 solution...
May 16, 2018: ACS Nano
Denis Selnihhin, Steffen Møller Sparvath, Søren Preus, Victoria Birkedal, Ebbe Sloth Andersen
Biosensors play increasingly important roles in many fields, from clinical diagnosis to environmental monitoring, and there is a growing need for cheap and simple analytical devices. DNA nanotechnology provides methods for the creation of sophisticated biosensors, however many of the developed DNA-based sensors are limited by cumbersome and time-consuming readouts involving advanced experimental techniques. Here we describe design, construction and characterization of an optical DNA origami nano-biosensor device exploiting arrays of precisely positioned organic fluorophores...
May 15, 2018: ACS Nano
Susanne Wintzheimer, Tim Granath, Maximilian Oppmann, Thomas Kister, Thibaut Thai, Tobias Kraus, Nicolas Vogel, Karl Mandel
Under the right process conditions, nanoparticles can cluster together to form defined particular structures, which can be termed supraparticles. Controlling the size, shape, and morphology of such entities is a central step in various fields of science and technology, ranging from colloid chemistry and soft matter physics to powder technology and pharmaceutical and food sciences. These diverse scientific communities have been investigating formation processes and structure/property relations of such supraparticles under completely different boundary conditions...
May 15, 2018: ACS Nano
Shanshan Wang, Hidetaka Sawada, Xiaoyu Han, Si Zhou, Sha Li, Zheng Xiao Guo, Angus I Kirkland, Jamie H Warner
We show that Pt nanoclusters preferentially nucleate along the grain boundaries (GBs) in polycrystalline MoS2 monolayer films, with dislocations acting as the seed site. Atomic resolution studies by aberration-corrected annular dark-field scanning transmission electron microscopy reveal periodic spacing of Pt nanoclusters with dependence on GB tilt angles and random spacings for the antiphase boundaries ( i.e., 60°). Individual Pt atoms are imaged within the dislocation core sections of the GB region, with various positions observed, including both the substitutional sites of Mo and the hollow center of the octahedral ring...
May 15, 2018: ACS Nano
Gustav Nystrom, Mario Arcari, Jozef Adamcik, Ivan Usov, Raffaele Mezzenga
Understanding how nanostructure and nanomechanics influence physical material properties on the micro- and macroscale is an essential goal in soft condensed matter research. Mechanisms governing fragmentation and chirality inversion of filamentous colloids are of specific interest because of their critical role in load-bearing and self-organizing functionalities of soft nanomaterials. Here we provide a fundamental insight into the self-organization across several length scales of nanocellulose, an important bio-colloid system with wide-ranging applications as structural, insulating and functional material...
May 14, 2018: ACS Nano
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