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Dermatology Research and Practice

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https://www.readbyqxmd.com/read/28611842/betulin-based-oleogel-to-improve-wound-healing-in-dystrophic-epidermolysis-bullosa-a-prospective-controlled-proof-of-concept-study
#1
Agnes Schwieger-Briel, Dimitra Kiritsi, Christoph Schempp, Cristina Has, Hauke Schumann
INTRODUCTION: Skin fragility and recurrent wounds are hallmarks of hereditary epidermolysis bullosa (EB). Treatment options to accelerate wound healing are urgently needed. Oleogel-S10 contains a betulin-rich triterpene extract from birch bark. In this study, we tested the wound healing properties of topical Oleogel-S10 in patients with dystrophic EB. METHODS: We conducted an open, blindly evaluated, controlled, prospective phase II pilot trial in patients with dystrophic EB (EudraCT number 2010-019945-24)...
2017: Dermatology Research and Practice
https://www.readbyqxmd.com/read/28487726/impaired-healing-of-a-cutaneous-wound-in-an-inducible-nitric-oxide-synthase-knockout-mouse
#2
Takashi Kitano, Hiroshi Yamada, Maki Kida, Yuka Okada, Shizuya Saika, Munehito Yoshida
Background. We investigated the effects of loss of inducible nitric oxide synthase (iNOS) on the healing process of cutaneous excisional injury by using iNOS-null (KO) mice. Population of granulation tissue-related cell types, that is, myofibroblasts and macrophages, growth factor expression, and reepithelialization were evaluated. Methods. KO and wild type (WT) mice of C57BL/6 background were used. Under general anesthesia two round full-thickness excision wounds of 5.0 mm in diameter were produced in dorsal skin...
2017: Dermatology Research and Practice
https://www.readbyqxmd.com/read/28373880/effects-of-multipolar-radiofrequency-and-pulsed-electromagnetic-field-treatment-for-face-and-neck-rejuvenation
#3
Thais Cristina Ferraz de Oliveira, Sheyla de Fatima Soares Rocha, Daniel Gontijo Ramos, Camila Gontijo Ramos, Michelle Vanessa Dos Anjos Carvalho, Mariana Gontijo Ramos
Skin aging is a gradual process that leads to wrinkle formation, laxity, and overall changes in skin appearance. In recent years, the demands to noninvasive treatments for facial rejuvenation increased, along with a variety of technologies and devices, such as radiofrequency. The present study aimed to evaluate the clinical effects of a multipolar radiofrequency and pulsed electromagnetic field treatment for face and neck rejuvenation. Eleven patients with mild to moderate grades of photoaging underwent eight radiofrequency and pulsed electromagnetic field treatment sessions, once a week...
2017: Dermatology Research and Practice
https://www.readbyqxmd.com/read/28293257/the-effectiveness-of-a-5-retinoic-acid-peel-combined-with-microdermabrasion-for-facial-photoaging-a-randomized-double-blind-placebo-controlled-clinical-trial
#4
Gita Faghihi, Saghi Fatemi-Tabaei, Bahareh Abtahi-Naeini, Amir Hossein Siadat, Giti Sadeghian, Mohammad Ali Nilforoushzadeh, Hamed Mohamadian-Shoeili
Background. Tretinoin has been shown to improve photoaged skin. This study was designed to evaluate the efficacy and tolerability of a 5% retinoic acid peel combined with microdermabrasion for facial photoaging. Materials and Methods. Forty-five patients, aged 35-70, affected by moderate-to-severe photodamage were enrolled in this trial. All patients received 3 sessions of full facial microdermabrasion and 3 sessions of either 5% retinoic acid peel or placebo after the microdermabrasion. Efficacy was measured using the Glogau scale...
2017: Dermatology Research and Practice
https://www.readbyqxmd.com/read/28167957/histological-and-immunohistochemical-evaluation-of-the-efficacy-of-a-new-cosmetic-formulation-in-the-treatment-of-skin-photoaging
#5
M T Truchuelo, N Jiménez, L Miguel-Gomez, A Hermosa, N Sánchez-Neila, J Cuevas
Objective. Mechanism of action of cosmetic products is not often studied. The aim of this study is to determine the histological, immunohistochemical, and clinical changes of a new cosmetic formulation. Methods. Prospective, single-blind, patient-controlled, randomized study in 10 volunteers with mild to moderate skin photoaging on the back of their hands. The product was applied on one hand and a standard cream on the other hand, twice a day for three months. Standardized photographs were taken on basal (T0) and final visit (T1) and skin biopsies were performed...
2017: Dermatology Research and Practice
https://www.readbyqxmd.com/read/28003819/clinicomycological-characterization-of-superficial-mycoses-from-a-tertiary-care-hospital-in-nepal
#6
Sundar Khadka, Jeevan Bahadur Sherchand, Dinesh Binod Pokharel, Bharat Mani Pokhrel, Shyam Kumar Mishra, Subhash Dhital, Basista Rijal
Background. Superficial mycosis is a common fungal infection worldwide, mainly caused by dermatophytes. However, the prevalence of species varies geographically. In addition, fungal treatment is best guided according to species isolated. This study was carried out to determine the clinical as well as mycological profile of superficial mycoses in a tertiary care hospital, Nepal. Methods. This was a prospective case-control laboratory based study conducted over a period of six months from January to June 2014 at Tribhuvan University Teaching Hospital, Nepal...
2016: Dermatology Research and Practice
https://www.readbyqxmd.com/read/27899949/corrigendum-to-effect-of-narrow-band-ultraviolet-b-phototherapy-and-methotrexate-on-microrna-146a-levels-in-blood-of-psoriatic-patients
#7
Amal Abou El-Fadle, Asmaa M Ele-Refaei, Fatma M El-Esawy
[This corrects the article DOI: 10.1155/2015/145769.].
2016: Dermatology Research and Practice
https://www.readbyqxmd.com/read/27885324/clinical-outcome-of-a-novel-anti-cd6-biologic-itolizumab-in-patients-of-psoriasis-with-comorbid-conditions
#8
Vinay Singh
Psoriasis is a common, chronic, immune mediated, inflammatory disease of skin characterized by red patches enclosed with white scales and affects 2-3% of people in the world. Topical therapy, phototherapy, and systemic therapy were employed for management of disease from many last decades. However, long term uses of these agents are associated with unwanted effects and toxicities. Recently, Itolizumab has been developed as world's first anti-CD6 humanized monoclonal IgG1 antibody for the management of moderate-to-severe chronic plaque psoriasis in India...
2016: Dermatology Research and Practice
https://www.readbyqxmd.com/read/27807445/comparison-of-european-standard-patch-test-results-of-330-patients-from-an-occupational-diseases-hospital
#9
Özge Gündüz, Aslı Aytekin, Engin Tutkun, Hınç Yılmaz
Background and Aim. Contact dermatitis (CD) is the most prevalent occupational skin disease with a significant impact on quality of life. Patch testing is used for the identification of responsible allergens which may improve protective and preventive measures in the workplace. Herein, we aim to identify the demographic characteristics and occupation of patients with early diagnosis of occupational CD and compare patch test results. Materials and Methods. The study included 330 patients referred to our clinic between April 2009 and April 2011 and who were patch-tested with 28-allergen European Standard Test...
2016: Dermatology Research and Practice
https://www.readbyqxmd.com/read/27774100/recurrence-of-dysplastic-nevi-is-strongly-associated-with-extension-of-the-lesions-to-the-lateral-margins-and-into-the-deep-margins-through-the-hair-follicles-in-the-original-shave-removal-specimens
#10
Amin Maghari
Melanocytic nevi, including dysplastic or atypical nevi (DN), can recur or persist following shave removal procedures, and recurrence may resemble melanoma, both clinically and histologically (pseudomelanoma). Recurrence may originate from proliferation of the remaining neoplastic melanocytes following incomplete removal. The present study determines the rate and etiology of this event. A cross-sectional analysis of 110 excision specimens showing histological recurrence was performed, and these specimens were compared to the slides of the original shave specimens showing mildly atypical DN...
2016: Dermatology Research and Practice
https://www.readbyqxmd.com/read/27738425/profile-of-skin-disorders-in-unreached-hilly-areas-of-north-india
#11
Deepak Dimri, Venkatashiva Reddy B, Amit Kumar Singh
Background. The pattern of skin morbidity in an area depends on climate, geography, socioeconomic status, nutrition, genetics, and habits of the community. Objective. The objective of the present study was to describe the morbidity profile of patients attending dermatology outpatient department in a tertiary care centre of Garhwal hills, North India. Methodology. This is a record based study carried out using the morbidity registers. Patient details, diagnosis, and treatment provided by physicians were documented in the morbidity register...
2016: Dermatology Research and Practice
https://www.readbyqxmd.com/read/27437000/is-there-a-relation-between-abo-blood-groups-and-clinical-outcome-in-patients-with-pemphigoid-a-case-control-study
#12
Sedigheh Bakhtiari, Parviz Toosi, Somayyeh Azimi, Nafiseh Esmaili, Ali Montazami, Nasrin Rafieian
Background. Relationship between blood groups and dermatologic diseases remains controversial and was not yet fully elucidated nor explained clearly. The aim of this study was to examine if any relation exists between different types of pemphigoid diseases and ABO blood group. Methods. In this case-control study, 159 pemphigoid patients and 152 healthy matched-controls were evaluated. All blood group (including Rh status) data for the study was obtained from the hospital medical records. Statistical comparisons were completed with chi-square test and logistic regression...
2016: Dermatology Research and Practice
https://www.readbyqxmd.com/read/27247564/pattern-of-pediatric-dermatoses-in-a-tertiary-care-hospital-of-western-nepal
#13
Yogesh Poudyal, Annu Ranjit, Santosh Pathak, Nagendra Chaudhary
Pediatric dermatoses are one of the most common presentations in a dermatology clinic and reflect the health and hygiene status of children. The incidence and severity of these skin lesions are influenced by geographical area, seasonal and cultural factors, and socioeconomic status. This study was done to show the prevalence of different pediatric dermatoses in a tertiary care hospital of Western Nepal. Chart reviews of children aged one day to 17 years, presenting to Universal Medical College Teaching Hospital, Nepal, from 1 September 2014 to 30 august 2015, were done...
2016: Dermatology Research and Practice
https://www.readbyqxmd.com/read/27148363/a-comparison-between-the-effects-of-glucantime-topical-trichloroacetic-acid-50-plus-glucantime-and-fractional-carbon-dioxide-laser-plus-glucantime-on-cutaneous-leishmaniasis-lesions
#14
Fariba Jaffary, Mohammad Ali Nilforoushzadeh, Amirhossein Siadat, Elaheh Haftbaradaran, Nazli Ansari, Elham Ahmadi
Background. Cutaneous leishmaniasis is an endemic disease in Iran. Pentavalent antimonial drugs have been the first line of therapy in cutaneous leishmaniasis for many years. However, the cure rate of these agents is still not favorable. This study was carried out to compare the efficacies of intralesional glucantime with topical trichloroacetic acid 50% (TCA 50%) + glucantime and fractional carbon dioxide laser + glucantime in the treatment of cutaneous leishmaniasis. Methods. A total of 90 patients were randomly divided into three groups of 30 to be treated with intralesional injection of glucantime, a combination of topical TCA 50% and glucantime, or a combination of fractional laser and glucantime...
2016: Dermatology Research and Practice
https://www.readbyqxmd.com/read/27143961/jumihaidokuto-shi-wei-ba-du-tang-a-kampo-formula-decreases-the-disease-activity-of-palmoplantar-pustulosis
#15
Megumi Mizawa, Teruhiko Makino, Chieko Inami, Tadamichi Shimizu
Palmoplantar pustulosis (PPP) is a chronic skin disease characterized by sterile intraepidermal pustules associated with erythematous scaling on the palms and soles. Jumihaidokuto is a traditional herbal medicine composed of ten medical plants and has been given to patients with suppurative skin disease in Japan. This study investigated the effect of jumihaidokuto on the disease activity in PPP patients (n = 10). PPP patients were given jumihaidokuto (EKT-6; 6.0 g per day) for 4 to 8 weeks in addition to their prescribed medications...
2016: Dermatology Research and Practice
https://www.readbyqxmd.com/read/27143960/altered-levels-of-serum-zinc-and-cadmium-in-patients-with-chronic-vesiculobullous-hand-and-feet-dermatitis
#16
Swastika Suvirya, Alpna Thakur, S S Pandey, S K Tripathi, Durgesh Kumar Dwivedi
Micronutrients serve many important functions in our body and altered levels of heavy and trace metals are associated with cutaneous and systemic disorders. Vesicular palmoplantar eczema is an entity whose etiopathogenesis is a mystery. In this prospective case-noncase study blood levels of Zinc and Cadmium in 37 patients of chronic vesiculobullous hand dermatitis were estimated and compared with 40 noncases with similar age and gender distributions. Low serum Zinc levels were found in patients as compared to noncases...
2016: Dermatology Research and Practice
https://www.readbyqxmd.com/read/27069472/effects-of-topical-emu-oil-on-burn-wounds-in-the-skin-of-balb-c-mice
#17
Mohammad Afshar, Reza Ghaderi, Mahmoud Zardast, Parvin Delshad
The goal of this study was to determine the effect of topical Emu oil on the healing of burn wounds and hair follicle restoration in superficial II-degree burns in the skin of Balb/c mice. Thirty-two male Balb/c mice with burns on the back of the neck were divided into two groups: The Emu oil group received topical Emu oil twice daily, whereas the control was left untreated. Skin biopsies were obtained on days 4, 7, 10, and 14 of the experiment. Then the specimens were viewed with Olympus SZX research microscope...
2016: Dermatology Research and Practice
https://www.readbyqxmd.com/read/27069471/promising-option-for-treatment-of-striae-alba-fractionated-microneedle-radiofrequency-in-combination-with-fractional-carbon-dioxide-laser
#18
Farahnaz Fatemi Naeini, Shadi Behfar, Bahareh Abtahi-Naeini, Shima Keyvan, Mohsen Pourazizi
Background. A consistent treatment has not been proposed for treatment of Striae Alba (SA). The present study was designed to compare the fractionated microneedle radiofrequency (FMR) alone and in combination with fractional carbon dioxide laser (FMR + CO2) in the treatment of SA. Methods. Forty-eight pairs of SA from six patients were selected. Right or left SAs were randomly assigned to one of the treatment groups. The surface area of the SA before and after treatment and clinical improvement using a four-point scale were measured at the baseline, after one and three months...
2016: Dermatology Research and Practice
https://www.readbyqxmd.com/read/27051415/production-of-a-self-aligned-scaffold-free-of-exogenous-material-from-dermal-fibroblasts-using-the-self-assembly-technique
#19
Stéphane Chabaud, Stéphane Bolduc
Many pathologies of skin, especially ageing and cancer, involve modifications in the matrix alignment. Such tissue reorganization could have impact on cell behaviour and/or more global biological processes. Tissue engineering provides accurate study model by mimicking the skin and it allows the construction of versatile tridimensional models using human cells. It also avoids the use of animals, which gave sometimes nontranslatable results. Among the various techniques existing, the self-assembly method allows production of a near native skin, free of exogenous material...
2016: Dermatology Research and Practice
https://www.readbyqxmd.com/read/27047542/clinicoepidemiological-study-of-different-types-of-warts
#20
Shruti S Ghadgepatil, Sanjeev Gupta, Yugal K Sharma
Background. Warts are cutaneous and, sometimes, mucosal lesions caused by one of the several human papilloma viruses. Aim. Assessment of the clinicoepidemiological aspects of warts. Materials and Methods. One hundred consecutive patients of warts presenting to the department of our institution were assigned two broad locational groups: genital and nongenital warts, the latter subdivided into common, plane, palmoplantar, mosaic, and digitate/filiform. Results. Ninety had nongenital and 10 had genital warts in our study; common (42%), palmoplantar (20%), and plane (18%) were the common types of the nongenital warts...
2016: Dermatology Research and Practice
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