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Biomarkers in Medicine

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https://www.readbyqxmd.com/read/29345157/evaluation-of-serum-cysteine-rich-protein-61-levels-in-patients-with-coronary-artery-disease
#1
Jingang Deng, Xiaoxian Qian, Jianping Li, Yanghua Li, Yang Li, Yijun Luo
AIM: The aim is to evaluate serum cysteine-rich protein 61 (Cyr61) levels in patients with coronary artery disease (CAD). PATIENTS & METHODS: Serum Cyr61 levels were measured in 180 patients with CAD and 74 participants without CAD. RESULTS: Serum Cyr61 levels were significantly higher in CAD patients. Patients with acute coronary syndrome showed significantly higher Cyr61 than those with stable angina pectoris. Serum Cyr61 levels in complex lesion group were significantly higher...
January 18, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29338319/clinical-evaluation-of-circulating-mir-548a-3p-and-20a-expression-in-malignant-pleural-mesothelioma-patients
#2
Marwa Matboli, Ayman E Shafei, Ahmed Em Azazy, Maged Reda, Nashwa El-Khazragy, Ahmed Aly Nagy, Mahmoud A Ali, Mohamed Sobhi, Omar Abdel-Rahman
AIM: miRNAs may act as promising diagnostic and prognostic biomarkers of mesothelioma. This study integrates serum  miR-548a-3p and miR-20a expression based on in silico data analysis followed by clinical validation in malignant mesothelioma patients (malignant pleural mesothelioma [MPM]). PATIENTS & METHODS: Serum miR-548a-3p and  miR-20a level was assessed in the serum of patients with MPM, chronic asbestos exposure and healthy volunteers by quantitative real-time PCR...
January 17, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29338306/biomarkers-for-assessing-the-effectiveness-of-immunotherapy-in-breast-cancer
#3
Mellissa J Nixon, Justin M Balko
No abstract text is available yet for this article.
January 17, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29327610/the-44th-congress-of-the-international-society-of-oncology-and-biomarkers-rio-de-janeiro-brazil-7-10-september-2017
#4
Judita Kinkorová
The 44th Congress of the International Society of Oncology and Biomarkers: Rio de Janeiro, Brazil, 7-10 September 2017 The 44th congress followed the previous one of  International Society of Oncology and Biomarkers (ISOBM) that took place in Chicago (USA) in 2016. The title of the 44th Annual congress was: 'Biomarkers in oncology: new horizons and challenges in the diagnosis and treatment of cancer' [ 1 ]. The congress was co-organized by ISOBM, European Group on Tumor Markers (EGTM) and Brazilian Society of Clinical Pathology SBPC/ML...
January 12, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29327601/syndecan-1-as-a-biomarker-for-sepsis-survival-after-major-abdominal-surgery
#5
Maximilian S Holzmann, Martin S Winkler, Mike S Strunden, Jakob R Izbicki, Gerhard Schoen, Gillis Greiwe, Hans O Pinnschmidt, Annika Poppe, Bernd Saugel, Guenter Daum, Alwin E Goetz, Kai Heckel
AIM: Sepsis is a serious complication following surgery and identification of patients at risk is of high importance. Syndecan-1 (sSDC1) levels are known to be elevated during sepsis. MATERIALS & METHODS: Fifty-five patients scheduled for major abdominal surgery were prospectively included and sSDC1 concentrations were measured during hospital stay. RESULTS: Patients with postoperative sepsis showed a continued increase of sSDC1 levels and exhibited higher median sSDC1 concentrations at day 1 compared with nonseptic patients 90...
January 12, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29327600/population-based-serum-omentin-1-levels-paradoxical-association-with-cardiometabolic-disorders-primarily-in-men
#6
Altan Onat, Evin Ademoglu, Yusuf Karadeniz, Gunay Can, Ahmet Okan Uzun, Barıs Simsek, Aysem Kaya
AIM: The conflicting relationships of serum omentin with inflammation markers and cardiometabolic disorders were investigated. Results & methodology: Unselected 864 population-based middle-aged adults were cross-sectionally studied by sex-specific omentin tertiles. Men in the lowest omentin tertile (T1) had lower systolic blood pressure, HbA1c and glucose values and tended in T3 to higher lipoprotein(a) levels. Logistic regression analysis, adjusted for four covariates, revealed significant independent associations with the presence of hypertension and diabetes only in men...
January 12, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29327597/endothelial-cell-derived-microvesicles-potential-mediators-and-biomarkers-of-pathologic-processes
#7
Veronika Vítková, Jan Živný, Jan Janota
This review focuses on the formation, composition and function of endothelial microvesicles (MV), often called microparticles (MP). MV release is a controlled event and is considered a hallmark of cellular activation or alteration. MV may affect the function of target cells through surface interaction and receptor activation, cellular fusion and the delivery of intravesicular cargo. Endothelial MV are released as a consequence of endothelial activation during inflammation and have been described to affect hemostasis, various aspects of inflammatory reaction, vessel formation, apoptosis and cell survival, endothelial cell differentiation and function...
January 12, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29327595/the-pretransplant-neutrophil-lymphocyte-ratio-as-a-new-prognostic-predictor-after-liver-transplantation-for-hepatocellular-cancer-a-systematic-review-and-meta-analysis
#8
Zheng-Guang Xu, Cheng-Jie Ye, Lin-Xun Liu, Gang Wu, Zhan-Xue Zhao, Yong-Zhen Wang, Bing-Qiang Shi, Yong-Hong Wang
AIM: Recently, many reports showed that the pretransplant neutrophil-lymphocyte ratio (NLR) may be correlated with the prognosis of patients undergoing liver transplantation (LT) for hepatocellular cancer (HCC). However, their results still remained controversial. Thus we performed a meta-analysis of 13 studies to estimate the prognostic value of pretransplant NLR. METHODS: Databases including PubMed, Embase, Cochrane Library and Web of Science were searched to September 2017...
January 12, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29318905/multiparametric-mri-for-early-detection-of-diffuse-liver-disease-an-interview-with-david-breen
#9
David J Breen
David J Breen is Associate Professor of Radiology and previous Clinical Director of Radiology at University Hospital Southampton. His interests are in abdominal imaging and intervention, particularly of hepato-pancreato-biliary (HPB)and renal disease. He has a major interest in image-guided tumor ablation and improving outcomes from these procedures. He has previously served as Vice Chair of the NHS England Clinical Reference Group in Interventional Radiology and for the NIHR/NCRN Upper GI Clinical Studies Group...
January 10, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29243525/galectin-3-and-outcomes-after-anterior-wall-myocardial-infarction-treated-by-primary-percutaneous-coronary-intervention
#10
Giuseppe Di Tano, Giorgio Caretta, Renata De Maria, Luca Bettari, Marina Parolini, Sophie Testa, Salvatore Pirelli
AIM: Galectin-3 (Gal-3), a biomarker of inflammation, tissue repair and fibrogenesis, is associated to left ventricular remodeling after ST-elevated myocardial infarction (STEMI), but its relation with long-term outcomes is unclear. METHODS: In 103 consecutive patients with a first anterior STEMI treated by primary angioplasty, we assayed Gal-3 and NT-proBNP. RESULTS: Age was 65 (56-76) years, 28% were women. During 18 ± 13 months, 20 patients (19...
December 15, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29243509/loss-of-mtap-expression-is-a-negative-prognostic-marker-in-ewing-sarcoma-family-of-tumors
#11
Lucas Faria Abrahao-Machado, Bruno Antunes, Renee Zon Filippi, Sahlua Volc, Erica Boldrini, Weder P Menezes, Rui M Reis, Olavo Pires de Camargo
AIM: The Ewing sarcoma family of tumors (ESFT) is a group of malignant small round cell neoplasms of bones and soft tissues closely histogenetically related. Methylthioadenosine phosphorylase (MTAP) deficiency has been recently associated with increased tumor aggressiveness and poor outcomes in different types of neoplasms. However, the expression of this biomarker and its biological role in ESFT remain largely unknown. METHODS: Immunohistochemical expression of MTAP was accessed in 112 patients with ESFT in a tissue microarray platform and associated with clinicopathological parameters and overall survival (OS)...
December 15, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29243496/increased-expression-of-cd44-is-associated-with-more-aggressive-behavior-in-clear-cell-renal-cell-carcinoma
#12
Leili Saeednejad Zanjani, Zahra Madjd, Maryam Abolhasani, Arezoo Rasti, Oystein Fodstad, Yvonne Andersson, Mojgan Asgari
AIM: Although CD44 has been suggested as a prognostic marker in renal cell carcinoma (RCC), the prognostic significance of this marker in three main subtypes of RCC is still unclear. Thus, the present study was conducted to evaluate the expression and prognostic significance of CD44 as a cancer stem cell marker in different histological subtypes of RCC. METHODOLOGY/RESULTS: CD44 expression was evaluated in 206 well-defined renal tumor samples using immunohistochemistry on tissue microarrays...
December 15, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29240461/clinicopathological-significance-of-bmi-1-overexpression-in-esophageal-cancer-a-meta-analysis
#13
Jihong Liu, Kai Liu, Xianli Jiang, Xueli Wang, Yunzhao Chen, Xiaobin Cui, Lijuan Pang, Shugang Li, Chunxia Liu, Hong Zou, Lan Yang, Jin Zhao, Yan Qi, Jian Ming Hu, Feng Li
AIM: The clinicopathological effects of Bmi-1 expression in esophageal cancer remain widely disputed. Our aim was to clarify this relationship. METHODS: Available studies were retrieved from diverse databases. Review Manager 5.3 and Stata 12.0 software were used to identify correlations between Bmi-1 expression and the clinicopathological features of esophageal cancer. RESULTS: From 16 studies, 1523 esophageal cancer patients were analyzed...
December 14, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29240459/downregulated-expression-of-hsa_circ_0074362-in-gastric-cancer-and-its-potential-diagnostic-values
#14
Yi Xie, Yongfu Shao, Weiliang Sun, Guoliang Ye, Xinjun Zhang, Bingxiu Xiao, Junming Guo
AIM: To explore the diagnostic value of hsa_circ_0074362 in the screening of gastric cancer. METHODS: The expression levels of hsa_circ_0074362 in 127 gastric cancer tissues and paired adjacent normal tissues, 83 gastritis tissues and six gastric cancer cell lines were first detected by quantitative reverse transcription-polymerase chain reaction. Then, the relationship between its levels and clinicopathological factors of patients with gastric cancer was analyzed...
December 14, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29240450/letter-in-response-to-tp-e-interval-and-tp-e-qt-ratio-before-and-after-catheter-ablation-in-patients-with-premature-ventricular-complexes
#15
Ahmet Korkmaz, Deniz Sahin, Umit Guray
AIM: Recently fragmented QRS (fQRS) on ECG has been introduced as a predictor of myocardial scarring and myocardial ischemia in coronary artery disease. OBJECTIVE: The aim of this study was to investigate the relationship between fQRS and fractional flow reserve (FFR) results in patients with the intermediate degree of coronary artery stenosis. METHODS: A total of 301 consecutive patients who underwent coronary angiography and FFR measurement for intermediate coronary artery stenosis were included in the study...
December 14, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29235891/lipid-biomarkers-for-the-peroxisomal-and-lysosomal-disorders-their-formation-metabolism-and-measurement
#16
Ryuichi Mashima, Masamitsu Maekawa
Lipid biomarkers play important roles in the diagnosis of and monitoring of treatment in peroxisomal disorders and lysosomal storage disorders. Today, a variety of lipids, including very long chain fatty acids, glycolipids, bile acids and the oxidation products of cholesterol, have been considered as biomarkers for these disorders. In this brief review, the authors summarized the recent advances regarding these lipid biomarkers in terms of their formation, metabolism and measurement in these disorders. An understanding of these biomarkers will offer a key to the development of novel diagnoses and help create more effective therapies in the future...
December 13, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29235881/prediction-of-pancreatic-cancer-risk-and-therapeutic-response-with-next-generation-sequencing
#17
Ioannis D Kyrochristos, Demosthenes E Ziogas, Georgios K Glantzounis, Dimitrios H Roukos
No abstract text is available yet for this article.
December 13, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29219009/micrornas-as-potential-prognosticators-of-neurological-outcome-in-out-of-hospital-cardiac-arrest-patients
#18
Sarah S Gul, Karl Huesgen, Kevin K Wang, Joseph A Tyndall
Out-of-hospital cardiac arrest survival rates have increased due to advancement in resuscitative measures, yet approximately 90% of survivors ultimately die or have severe neurologic dysfunction caused by ischemic injury. Currently, there are few early prognostic indicators of which patients have possibility of meaningful recovery. This leads to uncertainty for families and clinicians, as well as aggressive, invasive and expensive treatments despite medical futility. Several biomarkers investigated in traumatic brain injury have shown prognostication potential in ischemic brain injury...
December 8, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29202602/clinical-significance-of-serum-anti-gm-csf-autoantibody-levels-in-autoimmune-pulmonary-alveolar-proteinosis
#19
Masaki Nishimura, Etsuro Yamaguchi, Ayumu Takahashi, Nobuhiro Asai, Eisuke Katsuda, Toyohiro Ohta, Yoshinori Ohtsuka, Kenshi Kosaka, Ayako Matsubara, Hiroyuki Tanaka, Norihito Yokoe, Akihito Kubo, Satoshi Konno, Kenji Baba
AIM: Precise clinical significance of antigranulocyte-macrophage colony stimulating factor (GM-CSF) autoantibody levels in autoimmune pulmonary alveolar proteinosis (aPAP) has not been well studied. METHODS: We obtained sera from 50 healthy controls, 46 aPAP patients, 50 with sarcoidosis, 52 with idiopathic interstitial pneumonia and 75 with pneumoconiosis. The clinical course of aPAP patients was assessed by scoring computed tomography images in 19 patients. RESULTS: The cut-off level of anti-GM-CSF IgG for discrimination between aPAP and other diffuse lung diseases was 2...
December 5, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29186979/the-need-for-immune-biomarkers-for-treatment-prognosis-and-response-in-genitourinary-malignancies
#20
Susan F Slovin
Immune biomarkers encompass a wide range of blood-borne and cell-associated molecules whose detection or expression may change in response to an immune therapy. These immune therapies encompass a range of platforms including autologous cellular products, in other words, dendritic cells, prime boost DNA vaccines, chimeric antigen receptor (CAR) T cells and checkpoint inhibitors. The response to checkpoint inhibitors by a particular cancer may not be necessarily associated with a change in a particular immune biomarker; other immune biomarkers are needed to assess their association with treatment response or a change in the biology that can impact on the immunologic milieu...
November 30, 2017: Biomarkers in Medicine
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