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Biomarkers in Medicine

Zeyuan Fan, Hanhua Ji, Yang Li, Xinwen Jian, Li Li, Tao Liu
AIM: To investigate the relationship between monocyte-to-lymphocyte ratio (MLR) and plaque vulnerability assessed by virtual histology intravascular ultrasound in patients with stable angina. METHODS: 133 patients with stable angina were enrolled. RESULTS: MLR was found to be an independent risk factor of thin cap fibrous atheroma (OR: 2.61; p = 0.025). MLR could differentiate thin cap fibrous atheroma with a sensitivity of 73.7% and a specificity of 61...
September 11, 2017: Biomarkers in Medicine
Shiva Kalantari, Mohsen Nafar
Membranous nephropathy (MN) is relatively major cause of nephrotic syndrome in adults which is recognized as an organ-specific autoimmune disease. The etiology of most cases is idiopathic, whereas the secondary MN is caused by systemic autoimmune diseases, infections, medications and malignancies. The idiopathic disease is developed by the formation of sub-epithelial immune complex deposits most likely due to binding the circulating auto-antibodies to intrinsic antigen on podocytes. The major auto antibody is the anti-phospholipase A2 receptor (anti-PLA2R), however, it is not enough sensitive...
September 11, 2017: Biomarkers in Medicine
Keith Fluegge
No abstract text is available yet for this article.
September 11, 2017: Biomarkers in Medicine
Theodore P Beauchaine, John N Constantino
In psychopathology research, endophenotypes are a subset of biomarkers that indicate genetic vulnerability independent of clinical state. To date, an explicit expectation is that endophenotypes be specific to single disorders. We evaluate this expectation considering recent advances in psychiatric genetics, recognition that transdiagnostic vulnerability traits are often more useful than clinical diagnoses in psychiatric genetics, and appreciation for etiological complexity across genetic, neural, hormonal and environmental levels of analysis...
September 11, 2017: Biomarkers in Medicine
Xiaoying Ye, Songwen Ju, Houquan Duan, Yongliang Yao, Jianfen Wu, Shao Zhong, Lei Chen, ShaSha Cao, Yongfang Xu, Xiaocui Zheng, Haiyan Wang, Yan Ge, Songguang Ju
AIM: Accumulating evidence suggested that challenge of the maternal-fetal interaction during pregnancy might cause the impairment of immunological hemostasis and lead to gestational diabetes mellitus (GDM) pathological process. Immune checkpoint molecule PD-1 is one of the critical molecule balancing immune response and immunological tolerance. METHODS: PD-1 expressions on T-cell subsets of GDM patients and control groups were measured via flow cytometric analysis and followed up...
September 11, 2017: Biomarkers in Medicine
Yu Zhang, Wenteng Hu, Liwei Wang, Biao Han, Ruijiang Lin, Ning Wei
AIM: We investigated the role of GOLPH2 in non-small-cell lung cancer (NSCLC). METHODS: We analyzed the relationship between the expression of GOLPH2 and the clinical pathological characteristics of patients with NSCLC. The function of GOLPH2 in NSCLC cell lines was also explored through overexpression and knockdown studies. RESULTS: The positive expression rate of GOLPH2 protein in NSCLC tissue was higher than that of normal lung tissue...
September 7, 2017: Biomarkers in Medicine
Peter Wostyn, Peter Paul De Deyn
A significant proportion of the astronauts who spend extended periods in microgravity develop ophthalmic abnormalities. Understanding this syndrome, called visual impairment and intracranial pressure (VIIP), has become a high priority for National Aeronautics and Space Administration, especially in view of future long-duration missions (e.g., Mars missions). Moreover, to ensure selection of astronaut candidates who will be able to complete long-duration missions with low risk of the VIIP syndrome, it is imperative to identify biomarkers for VIIP risk prediction...
September 4, 2017: Biomarkers in Medicine
Changlie Zhang, Zhihong Song, Guangji Yu
AIM: To investigate the clinical significance of E3 ubiquitin ligase Parkin in patients with adjuvant transarterial chemoembolization after curative resection of hepatocellular carcinoma. METHODS: Parkin expression of hepatocellular carcinomas was detected and its correlation with clinicopathological factors was analyzed with χ(2) test. The significance of Parkin in prognosis and recurrence was analyzed with log-rank test and the Cox-regression model. RESULTS: High expression of Parkin could result in lower recurrence-free survival rate instead of overall survival rate...
September 1, 2017: Biomarkers in Medicine
Xingwei Gu, Rong Jin, Xuping Mao, Jun Wang, Jintao Yuan, Guodong Zhao
AIMS: miR-181a and miR-181b have been investigated as prognostic biomarkers of colorectal cancer (CRC). However, there is controversy about the role of miR-181a and miR-181b in predicting CRC prognosis. Therefore, we performed this meta-analysis to evaluate prognostic values of miR-181a and miR-181b in CRC patients. MATERIALS & METHODS: Studies were systemically searched from publications and analyzed, and 999 CRC cases in nine studies were examined in this meta-analysis...
August 25, 2017: Biomarkers in Medicine
Kelly Hares, Alastair Wilkins
No abstract text is available yet for this article.
August 3, 2017: Biomarkers in Medicine
Selami Soylemez
Letter in regards to: Akboga MK, Balci KG, Maden O et al. Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease. Biomark. Med. 10(4), 375-383 (2016).
August 3, 2017: Biomarkers in Medicine
Mehmet Kadri Akboga, Samet Yilmaz
Letter in regards to: Akboga MK, Balci KG, Maden O et al. Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease. Biomark. Med. 10(4), 375-383 (2016). In response to: Soylemez S.Oxidative stress and SYNTAX score in patients with stable coronary artery disease. Biomark. Med. 11(8), doi:10.2217/bmm-2016-0326 (2017) (Epub ahead of print).
August 3, 2017: Biomarkers in Medicine
Richard E Frye, John C Slattery, Edward V Quadros
Autism spectrum disorder (ASD) has been linked to abnormalities in folate metabolism. Polymorphisms in folate genes may act in complex polygenic ways to increase the risk of developing ASD. Autoantibodies that block folate transport into the brain have been associated with ASD and children with ASD and these autoantibodies respond to high doses of a reduced form of folate known as folinic acid (leucovorin calcium). Some of the same abnormalities are also found in mothers of children with ASD and supplementing folate during preconception and gestational periods reduces the risk to the offspring from developing ASD...
August 3, 2017: Biomarkers in Medicine
Nan Jiang, Cheng-He Qin, Yi-Long Hou, Zi-Long Yao, Bin Yu
AIM: This study aimed to investigate the values of preoperative serum levels of white blood cell, erythrocyte sedimentation rate (ESR), C-reactive protein, procalcitonin, IL-6, TNF-α and serum amyloid A for diagnosis of chronic osteomyelitis (COM) in Chinese patients. METHODS: All 586 eligible patients were included for analysis. RESULTS: Outcomes revealed that positive ratios of TNF-α, ESR and IL-6 lied in top three. Taken predicted probability and detection cost into consideration, combination of ESR, IL-6 and TNF-α might be the optimal model due to its high predicted probability for COM (91...
August 3, 2017: Biomarkers in Medicine
Jinrong Zeng, Haijing Wu, Ming Zhao, Qianjin Lu
Systemic lupus erythematosus (SLE) is a complex and highly heterogeneous disease. By now, no novel drug has been approved by the US FDA in the past 50 years, except Belimumab, a monoclonal antibody to inhibit B-cell activating factor. The stagnating drug development of lupus may be due to our limited understanding of disease etiopathogenesis and the extreme heterogeneity of patient population. Thus, the individualized treatment for SLE becomes necessary. Recently, biomarkers have shown potential in individualized treatment...
August 3, 2017: Biomarkers in Medicine
Vahit Demir, Samet Yilmaz, Mehmet Kadri Akboga
AIM: We aimed to evaluate the relationships between monocyte-to-high-density lipoprotein ratio (MHR) and lymphocyte-to-monocyte ratio (LMR) and rheumatic mitral valve stenosis (RMVS). METHODOLOGY: A total of 368 patients with mitral stenosis and 80 healthy participants were included. Patients were categorized into two groups in respect to the severity of RMVS as mild-moderate group (mitral valve area ≥1.0 cm(2)) and severe group (mitral valve area <1.0 cm(2))...
August 3, 2017: Biomarkers in Medicine
Marwa Matboli, Ayman E Shafei, Hanan H Shehata, Nesreen Nabil, Nourhan Hossam, Ahmed Em Azazy, Ahmed Hf El-Tawdi, Omar Abdel-Rahman
AIM: This study integrates autophagy transcripts miRNAs expression based on bioinformatic analysis followed by clinical validation. METHODOLOGY: Cellular jun proto-oncogene mRNA, LAMP2 mRNA, miR-16 and miR-146a level were investigated in the serum and tissue of patients with hepatocellular carcinoma (HCC), chronic hepatitis C and healthy volunteers by quantitative real-time PCR. The prognostic power of this serum RNA panel was explored. RESULTS: The expression of serum cellular jun proto-oncogene mRNA, LAMP2 mRNA, miR-16 and miR-146a were positive in 85...
August 3, 2017: Biomarkers in Medicine
Anna Synakiewicz, Malgorzata Sawicka-Zukowska, Natalia Adrianowska, Grazyna Galezowska, Joanna Ratajczyk, Anna Owczarzak, Lucyna Konieczna, Teresa Stachowicz-Stencel
AIM: Childhood cancer remains one of the main cause of death in the pediatric population. Amino acids (AAs) level alterations in plasma are considered to play a role in carcinogenesis and further course of the disease. METHODS: Seventy-seven children with cancer, including 47 with hematological and 30 with solid tumors were enrolled in this study and compared with healthy children. Twenty-two plasma-free AAs were determined by HPLC with fluorometric detection. RESULTS: The results revealed significant decrease in glutamine levels for oncological patients and significant increase in aspartic acid, glutamic acid, asparagine, serine, citrulline, alanine, GABA, tryptophan, methionine, valine, phenylalanine and isoleucine levels in cancer children versus control...
August 3, 2017: Biomarkers in Medicine
George Kafatos, Daniela Niepel, Kimberley Lowe, Sophie Jenkins-Anderson, Hal Westhead, Tamer Garawin, Zuzana Traugottová, Antonios Bilalis, Edit Molnar, Jozsef Timar, Erika Toth, Nikolaos Gouvas, George Papaxoinis, Samuel Murray, Nadia Mokhtar, Hana Vosmikova, Pavel Fabian, Alena Skalova, Piotr Wójcik, Andrzej Tysarowski, Mario Barugel, J Han van Krieken, Jörg Trojan
AIM: A confirmed wild-type RAS tumor status is commonly required for prescribing anti-EGFR treatment for metastatic colorectal cancer. This noninterventional, observational research project estimated RAS mutation prevalence from real-world sources. MATERIALS & METHODS: Aggregate RAS mutation data were collected from 12 sources in three regions. Each source was analyzed separately; pooled prevalence estimates were then derived from meta-analyses. RESULTS: The pooled RAS mutation prevalence from 4431 tumor samples tested for RAS mutation status was estimated to be 43...
July 27, 2017: Biomarkers in Medicine
Youyou Yan, Xinjing Song, Zhibo Li, Jinpu Zhang, Jiajun Ren, Junduo Wu, Yali Li, Yinuo Guan, Junnan Wang
AIM: Granzyme B could induce apoptosis of target cell in acute myocardial infarction (AMI) and was identified as the target of miR-874-3p by searching the miRNA database. We aim to determine the levels of granzyme B and miR-874-3p as well as assay their correlations or predict powers in AMI. PATIENTS & METHODS: We measured levels of plasma granzyme B and miR-874-3p in 80 AMI patients or 40 healthy controls and assayed their correlations or predicted powers for AMI...
July 12, 2017: Biomarkers in Medicine
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