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Biomarkers in Medicine

Tingting Zeng, Liming Tan
Effective management of rheumatoid arthritis (RA) depends on early identification followed by timely invention and proper monitoring of treatment responses which remain challenges facing rheumatologists for lacking biomarkers of high sensitivity and specificity. 14-3-3η has been reported to be a novel RA-related biomarker inducing the expression of multiple factors mediating the pathogenesis of RA, and increasing the diagnostic capture when combined with rheumatoid factor and anticyclic citrullinated peptide antibody...
July 19, 2018: Biomarkers in Medicine
Un Jung Lee, ShengLi Tzeng, Yu-Chuan Chen, James J Chen
AIM: We develop a subgroup selection procedure using both prognostic and predictive biomarkers to identify four patient subpopulations: low- and high-risk responders, and low- and high-risk nonresponders. METHODS: We utilize three regression models to identify three sets of biomarkers: S, prognostic biomarkers; T, predictive biomarkers; and U, prognostic and predictive biomarkers. The prognostic signature C(S) combines with a predictive signature, either C(T) or C(U), to develop two procedures C(S,T) and C(S,U) for identification of four subgroups...
July 19, 2018: Biomarkers in Medicine
Thomas E Kaier, Bashir Alaour, Michael Marber
No abstract text is available yet for this article.
July 18, 2018: Biomarkers in Medicine
Marc Zanaty, Khaled Ajib, Mansour Alnazari, Elie El Rassy, Fouad Aoun, Kevin C Zorn, Assaad El-Hakim
AIM: Utility of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in predicting biochemical recurrence (BCR) in patients with localized prostate cancer. MATERIALS & METHODS: Retrospective analysis of patients operated by robot-assisted radical prostatectomy. Variables included were: NLR, PLR pre-operative prostate specific antigen, pathological Gleason score, surgical margins status, extracapsular extension, seminal vesical invasion, and lymph node status...
July 18, 2018: Biomarkers in Medicine
Gilbert Akankwasa, Liu Jianhua, Cheng Guixue, A N Changjuan, Qin Xiaosong
Urinary podocalyxin and nephrin are urine markers of podocyte dysfunction that may reflect the integrity of kidney's filtration barrier. Studies on their respective roles in glomerular diseases are still underway. However, the isolated and unsystematic manner in which they are being studied does not permit proper identification of their roles in each glomerular disease. As such, there is little or no appreciation of what research has already achieved and what remains to be achieved as the research direction is not clearly defined...
July 6, 2018: Biomarkers in Medicine
Maisa Kasanga, Lisheng Liu, Linlin Xue, Xianrang Song
AIM: We investigated HSP90α as screening biomarker for early colorectal cancer (CRC). METHODS & RESULTS: Seventy-seven CRC patients and 78 healthy controls were enrolled. Plasma HSP90α was significantly higher in CRC patients than in healthy controls (p < 0.05). levels were higher in late (stages III and IV) CRC than in early (stages I and II) CRC (p = 0.022). HSP90α conferred an advantage in the diagnosis of early CRC. Combination of HSP90α and carcinoembryonic antigen improved the diagnostic sensitivity (84...
June 25, 2018: Biomarkers in Medicine
Gang Li, Ying Song, Yun-Da Li, Ling-Jun Jie, Wei-Yin Wu, Jing-Zhou Li, Qiuwang Zhang, Yan Wang
AIM: To explore circulating miRNA-302 family members for acute heart failure (AHF) diagnosis. METHODS: Three groups of subjects, in other words, AHF patients, AHF free patients and healthy controls were recruited. Circulating levels of miR-302 family members were measured and analyzed for AHF diagnosis. RESULTS: Plasma miR-302s except miR-302f were significantly elevated in AHF patients. MiR-302b-3p had the highest area under curve value of 0...
June 14, 2018: Biomarkers in Medicine
Mario C Deng
Heart failure (HF) is a complex clinical syndrome that causes systemic hypoperfusion and failure to meet the body's metabolic demands. In an attempt to compensate, chronic upregulation of the sympathetic nervous system and renin-angiotensin-aldosterone leads to further myocardial injury, HF progression and reduced O2 delivery. This triggers progressive organ dysfunction, immune system activation and profound metabolic derangements, creating a milieu similar to other chronic systemic diseases and presenting as advanced HF with severely limited prognosis...
May 8, 2018: Biomarkers in Medicine
Yanjiao Ren, Xin Feng, Xin Xia, Yexian Zhang, Wenniu Zhang, Jing Su, Zhongyu Wang, Ying Xu, Fengfeng Zhou
AIM: The two genders are different ranging from the molecular to the phenotypic levels. But most studies did not use this important information. We hypothesize that the integration of gender information may improve the overall prediction accuracy. MATERIALS & METHODS: A comprehensive comparative study was carried out to test the hypothesis. The classification of the stages I + II versus III + IV of the clear cell renal cell carcinoma samples was formulated as an example...
April 30, 2018: Biomarkers in Medicine
Joseph J Fantony, Lauren E Howard, Ilona Csizmadi, Andrew J Armstrong, Amy L Lark, Colette Galet, William J Aronson, Stephen J Freedland
AIM: To test if Ki67 expression is prognostic for biochemical recurrence (BCR) after radical prostatectomy (RP). METHODS: Ki67 immunohistochemistry was performed on tissue microarrays constructed from specimens obtained from 464 men undergoing RP at the Durham and West LA Veterans Affairs Hospitals. Hazard ratios (HR) for Ki67 expression and time to BCR were estimated using Cox regression. RESULTS: Ki67 was associated with more recent surgery year (p < 0...
July 2018: Biomarkers in Medicine
Nicholas J Ashton, Michael Schöll, Kerstin Heurling, Eleni Gkanatsiou, Erik Portelius, Kina Höglund, Gunnar Brinkmalm, Abdul Hye, Kaj Blennow, Henrik Zetterberg
At the center of Alzheimer's disease pathogenesis is the aberrant aggregation of amyloid-β (Aβ) into oligomers, fibrils and plaques. Effective monitoring of Aβ deposition directly in patients is essential to assist anti-Aβ therapeutics in target engagement and participant selection. In the advent of approved anti-Aβ therapeutics, biomarkers will become of fundamental importance in initiating treatments having disease modifying effects at the earliest stage. Two well-established Aβ biomarkers are widely utilized: Aβ-binding ligands for positron emission tomography and immunoassays to measure Aβ42 in cerebrospinal fluid...
July 2018: Biomarkers in Medicine
Christopher J O'Conor, Tiffany Chen, Iván González, Dengfeng Cao, Yan Peng
Triple-negative breast cancer (TNBC) is an aggressive disease with poor outcome, and lacks targeted therapy. Recent studies suggest that cancer stem cells play an important role in tumorigenesis and tumor biology of TNBC. Both CD44+ /CD24- and ALDH1+ breast cancer stem cells are enriched in TNBC and may contribute to the propensity of TNBC for chemotherapy resistance and tumor metastasis. There is new evidence to support the evaluation of cancer stem cells in TNBC for diagnostic purposes. Targeting cancer stem cells may also be a promising, novel strategy for the treatment of TNBC...
July 2018: Biomarkers in Medicine
Panagiotis Paliogiannis, Alessandro G Fois, Salvatore Sotgia, Arduino A Mangoni, Elisabetta Zinellu, Pietro Pirina, Ciriaco Carru, Angelo Zinellu
The aim of this meta-analysis was to review the available evidence regarding the blood concentrations of the oxidative stress marker malondialdehyde (MDA) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. 14 studies were included in the meta-analysis (from inception to October 2017) with a total of 817 COPD patients and 530 healthy controls. Pooled MDA concentrations were significantly higher in patients with COPD than controls (standardized mean differences = 2...
July 2018: Biomarkers in Medicine
Tamara Knific, Katja Vouk, Andrej Vogler, Joško Osredkar, Manuela Gstöttner, René Wenzl, Tea Lanišnik Rižner
AIM: To evaluate preoperative levels of CA-125 and HE4 in patients with endometriosis-like symptoms and to construct diagnostic models. PATIENTS: Prospective case-control study included 124 endometriosis patients and 97 control patients. MATERIALS & METHODS: Logistic regression was used to construct diagnostic models based on serum biomarker levels and clinical data. RESULTS: A model with CA-125, BMI, information on cysts and dyspareunia had an area under the curve value of 0...
July 2018: Biomarkers in Medicine
Evangelos Oikonomou, Georgia Vogiatzi, Sotiris Tsalamandris, Konstantinos Mourouzis, Gerasimos Siasos, George Lazaros, Georgia Skotsimara, George Marinos, Manolis Vavuranakis, Dimitris Tousoulis
Heart failure (HF) with reduced and preserved ejection fraction constitutes two entities with distinct pathogenetic backgrounds sharing common features. Beyond natriuretic peptides, several novel biomarkers have been proven useful in the diagnosis, prognosis and treatment of HF. Biomarkers of myocardial fibrosis have a low diagnostic yield in subjects with acute HF but may add prognostic information, especially in patients with HF and preserved ejection fraction. Biomarkers of renal impairment identify subjects with worse prognosis independently of left ventricle ejection fraction while inflammatory markers have not been proven useful in patients with systolic or diastolic impairment...
July 2018: Biomarkers in Medicine
Jacek T Niedziela, Bartosz Hudzik, Bozena Szygula-Jurkiewicz, Jolanta U Nowak, Lech Polonski, Mariusz Gasior, Piotr Rozentryt
AIM: Albumin-to-globulin ratio (AGR) is emerged as a marker of impaired prognosis. We determined the predictive value of AGR in patients with heart failure with reduced ejection fraction (HFrEF). METHODOLOGY: 999 patients with HFrEF were enrolled. Rates of 1-year all-cause mortality were compared between AGR quartiles (Q). Moreover, multivariate survival analysis in Cox's regression model and receiver operating characteristic analyses were performed. RESULTS: 90-day and 1-year mortality was the highest in AGR Q1...
July 2018: Biomarkers in Medicine
Azul Islas-Hernandez, Hugo Seacatl Aguilar-Talamantes, Brenda Bertado-Cortes, Georgina de Jesus Mejia-delCastillo, Raul Carrera-Pineda, Carlos Fredy Cuevas-Garcia, Paola Garcia-delaTorre
AIM: Determine if serum levels of tau and BDNF can be used as severity biomarkers in multiple sclerosis (MS). PATIENTS & METHODS: Subjects with MS, older than 18 and younger than 55 years old were included; 74 patients with a diagnosis of relapsing-remitting MS, 11 with secondary-progressive MS, and 88 controls were included. Total tau and BDNF were measured by Western blot. RESULTS: Increased tau and decreased BDNF in MS patients compared with controls was found...
July 2018: Biomarkers in Medicine
Nathan C Bahr, Ryan Halupnick, Grace Linder, Reuben Kiggundu, Henry W Nabeta, Darlisha A Williams, Abdu K Musubire, Bozena M Morawski, Srinand Sreevatsan, David B Meya, Joshua Rhein, David R Boulware
AIM: Tuberculosis meningitis (TBM) diagnosis is difficult, new biomarkers are needed. We evaluated the diagnostic utility of delta-like 1 protein (DLL1), vitamin D binding protein (VDBP) and fetuin. METHODS: Biomarker concentrations were measured by ELISA in cryopreserved cerebrospinal fluid from 139 HIV-infected Ugandans with suspected meningitis. TBM was diagnosed by GeneXpert MTB/Rif or culture. Cohort diagnoses included TBM (n = 22), cryptococcal (n = 71), or aseptic meningitis (n = 16) and no meningitis (n = 30)...
July 2018: Biomarkers in Medicine
Martin R Turner
No abstract text is available yet for this article.
July 2018: Biomarkers in Medicine
Liming Tan, Qiaohua Wang, Tingting Zeng, Tingting Long, Xiaolin Guan, Sifan Wu, Wei Zheng, Huiying Fu, Yimei Meng, Yang Wu, Yongjian Tian, Jianlin Yu, Juanjuan Chen, Hua Li, Liping Cao
AIM: To investigate the clinical significance of detecting several biomarkers collectively in the diagnosis of rheumatoid arthritis (RA). METHODS: 128 RA patients, 174 non-RA patients and 80 healthy controls were enrolled. HLA-DR4 and HLA-DR53 were detected by the PCR-SSP method, 14-3-3η protein, anti-CCP and anti-Sa were detected by ELISA and DD was detected by latex immunoturbidimetric assay. RESULTS: The positive rates of HLA-DR4, HLA-DR53, 14-3-3η protein, anti-CCP and anti-Sa were obviously higher in the RA group (43...
July 2018: Biomarkers in Medicine
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