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Biomarkers in Medicine

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https://www.readbyqxmd.com/read/28534416/comparison-of-statistical-methods-for-detection-of-serum-lipid-biomarkers-for-mesothelioma-and-asbestos-exposure
#1
Rengyi Xu, Clementina Mesaros, Liwei Weng, Nathaniel W Snyder, Anil Vachani, Ian A Blair, Wei-Ting Hwang
AIM: We compared three statistical methods in selecting a panel of serum lipid biomarkers for mesothelioma and asbestos exposure. MATERIALS & METHODS: Serum samples from mesothelioma, asbestos-exposed subjects and controls (40 per group) were analyzed. Three variable selection methods were considered: top-ranked predictors from univariate model, stepwise and least absolute shrinkage and selection operator. Crossed-validated area under the receiver operating characteristic curve was used to compare the prediction performance...
May 23, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28379039/elevated-serum-il-39-in-patients-with-st-segment-elevation-myocardial-infarction-was-related-with-left-ventricular-systolic-dysfunction
#2
Yu Luo, Feng Liu, Huadong Liu, Hongdan Chen, Wenfei Cheng, Shaohong Dong, Wei Xiong
AIM: To investigate the changes and significance of circulating IL-39 in patients with acute coronary syndrome (ACS). PATIENTS & METHODS: Serum IL-39 levels in ACS patients and normal coronary arteries were measured. The correlations of IL-39 with high-sensitivity CRP, cTnI, N-terminal of the prohormone brain natriuretic peptide (NTproBNP) and left ventricular ejection fraction were investigated. RESULTS: The serum levels of IL-39 in ACS patients were significantly increased...
April 5, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28353371/the-systemic-synuclein-sampling-study-toward-a-biomarker-for-parkinson-s-disease
#3
Naomi P Visanji, Brit Mollenhauer, Thomas G Beach, Charles H Adler, Christopher S Coffey, Catherine M Kopil, Kuldip D Dave, Tatiana Foroud, Lana Chahine, Danna Jennings
The search for a biomarker for Parkinson's disease (PD) has led to a surge in literature describing peripheral α-synuclein (aSyn) in both biofluids and biopsy/autopsy tissues. Despite encouraging results, attempts to capitalize on this promise have fallen woefully short. The Systemic Synuclein Sampling Study (S4) is uniquely designed to identify a reproducible diagnostic and progression biomarker for PD. S4 will evaluate aSyn in multiple tissues and biofluids within the same subject and across the disease spectrum to identify the optimal biomarker source and provide vital information on the evolution of peripheral aSyn throughout the disease...
March 29, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28326824/osteopontin-its-potential-role-in-cancer-of-children-and-young-adults
#4
Gabrielle Karpinsky, Aleksandra Fatyga, Malgorzata Anna Krawczyk, Madeleine Chamera, Natalia Sande, Dagmara Szmyd, Ewa Izycka-Swieszewska, Ewa Bien
OBJECTIVE: Osteopontin (OPN) is aglyco-phosphoprotein, involved in tissue remodeling, inflammation and boneresorption. In various adult neoplasms OPN was shown to correlate with cancer progression, invasiveness and metastasis. AIM: to define the role of OPN in malignancies of children and young adults. MATERIAL AND METHODS: a structured PubMed and Google Scholar literature analysis based on reports published in English between I'1995 and XII'2015...
March 14, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28290211/influence-of-hematuria-and-infection-on-diagnostic-accuracy-of-urinary-lasp1-a-new-biomarker-for-bladder-carcinoma
#5
Elke Butt, Jan Ebbing, Lukas Bubendorf, Peter Ardelt
AIM: To further promote the clinical use of urinary LASP1 as biomarker for urothelial carcinoma of the bladder regarding limitations and alternative testing systems. PATIENTS & METHODS: Urine stabilization, alternative measurement systems and limitations by erythrocyte contamination and infection were investigated in 246 patients. RESULTS: Thimerosal allowed sufficient stabilization. Fluorescence-activated cell sorting analysis was not influenced by presence of erythrocytes or leukocytes and reliably urothelial carcinoma of the bladder but cell counts in specimen were low...
March 14, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28290210/changing-concept-in-treatment-of-asymptomatic-severe-aortic-stenosis-and-normal-ejection-fraction-time-for-biomarkers-reappraisal
#6
Marko D Banovic
The uncertainty of whether/how to treat asymptomatic patients with isolated severe aortic stenosis and normal left ventricular ejection fraction is one of the most topical in cardiovascular medicine. Recently, the AVATAR trial: first ever randomized trial in the setting of aortic stenosis has been started in an attempt to adequately address this 'burning issue'. In light of this fact it is important to identify biomarkers which might help in risk stratification of these patients, not only in the referring physician's office during a routine exam, but also for preoperative patients scheduled for surgical replacement/transcatheter aortic valve implantation...
March 14, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28290209/plasma-brain-derived-neurotrophic-factor-in-women-with-pelvic-pain-a-potential-biomarker-for-endometriosis
#7
Ana L Rocha, Erica L Vieira, Márcia C Ferreira, Laura M Maia, Antonio L Teixeira, Fernando M Reis
AIM: To test whether plasma BDNF levels are useful to predict the presence of endometriosis in women with pelvic pain. PATIENTS & METHODS: Prospective cross-sectional study including 67 consecutive women aged 24-49 years, scheduled for laparoscopy due to chronic pelvic pain. Preoperative plasma samples were assayed for BDNF using a commercial enzyme immunoassay. RESULTS: Women with ovarian endometrioma had higher preoperative plasma BDNF (1063 ± 157 pg/ml) compared with women with other benign ovarian tumors (537 ± 131 pg/ml, F = 2...
March 14, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28290208/reproducibility-in-biomarker-research-and-clinical-development-a-global-challenge
#8
Andreas Scherer
No abstract text is available yet for this article.
March 14, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28326826/predictive-value-of-the-c-reactive-protein-to-prealbumin-ratio-in-medical-icu-patients
#9
Li Li, Lihua Dai, Xiao Wang, Yao Wang, Luocheng Zhou, Miao Chen, Hairong Wang
AIM: This prospective study aimed to evaluate the relationship between the ratio of C-reactive protein-to-prealbumin (CRP/PAB) and clinical outcomes in medical intensive care unit patients. MATERIALS & METHODS: All 240 consecutive adult patients were enrolled in this study with demographic and clinical features collected. RESULTS: Compared with patients belonging to the CRP/PAB ≤0.24 group, hospital mortality and the total length of stay in hospital (TLSH) were significantly increased in patients in the CRP/PAB >0...
April 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28326825/role-of-biomarkers-in-predicting-diabetes-complications-with-special-reference-to-diabetic-foot-ulcers
#10
Sivakamasundari Pichu, Bhoomika M Patel, Subbu Apparsundaram, Ramesh K Goyal
Diabetic foot ulcer (DFU) is one of the major complications of diabetes and about 1% of people with diabetes have to go for lower limb amputation. With better understanding of the pathological basis of DFU, number of biomarkers like atrial natriuretic peptides, galectin-3, and cardiac troponins for diabetic cardiomyopathy, cystatin C for diabetics nephropathy and C-reactive protein for infection and procalcitonin could aid in early and noninvasive diagnosis especially when clinical signs are misleading. Predictive role of novel biomarkers in primary prevention however, requires additional studies considering sex, age and multiple complications in DFU...
April 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28326823/tp-e-interval-and-tp-e-qt-ratio-before-and-after-catheter-ablation-in-patients-with-premature-ventricular-complexes
#11
Çağrı Yayla, Fırat Özcan, Dursun Aras, Osman Turak, Özcan Özeke, Serkan Çay, Serkan Topaloğlu
AIM: Tp-e/QT ratio is a novel marker of ventricular repolarization. The aim of the study is to evaluate the Tp-e interval and Tp-e/QT ratio before and after radiofrequency ablation (RFA) for patients with frequent premature ventricular complexes (PVCs). PATIENTS & METHODS: The study included 151 consecutive patients who underwent RFA for treatment of symptomatic frequent PVCs. RESULTS: Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio (all p < 0...
April 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28240101/the-search-for-preoperative-biomarkers-for-thyroid-carcinoma-application-of-the-thyroid-circadian-clock-properties
#12
Charna Dibner, Samira Mercedes Sadowski, Frederic Triponez, Jacques Philippe
Accumulating evidence suggests that alterations in the molecular clocks underlying the circadian time-keeping system might be connected to changes in cell cycle, resulting in oncogenic transformation. The hypothalamic-pituitary-thyroid axis is driven by a circadian clock at several levels, with an endocrine feedback loop regulating thyroid-stimulating hormone. Changes in the expression levels of circadian and cell cycle markers may correlate with clinic-pathological characteristics in differentiated follicular thyroid carcinomas...
March 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28240100/correlations-between-lncrna-sox2ot-polymorphism-and-susceptibility-to-breast-cancer-in-a-chinese-population
#13
Xiuwu Tang, Yan Gao, Linxiang Yu, Yan Lu, Guanglin Zhou, Lifang Cheng, Kai Sun, Baoli Zhu, Ming Xu, Jingjing Liu
AIM: We evaluated the effect of lncRNA SOX2OT expression and its SNP in tumorigenesis and development of breast cancer (BC) in a case-control study. METHODS: A total of 1106 individuals, 505 newly diagnosed BC patients and 601 age-matched controls (±2 years) were testified. Real-time PCR was adopted for testing tissues' SOX2OT expression. Genotyping of rs9839776 were conducted by using SNaPshot assays. RESULTS: SOX2OT were overexpressed in BC tissues (p < 0...
March 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28240099/biomarkers-and-the-target-therapies-in-oncology-research-and-business
#14
Andrea Nicolini
No abstract text is available yet for this article.
March 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28240098/nanocytology-as-a-potential-biomarker-for-cancer
#15
Weibo Yu, Shivani Sharma, James K Gimzewski, Jianyu Rao
No abstract text is available yet for this article.
March 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28240097/soluble-intercellular-adhesion-molecule-1-a-potential-biomarker-for-pain-intensity-in-chronic-pain-patients
#16
Benjamin Luchting, Ludwig Christian Giuseppe Hinske, Banafscheh Rachinger-Adam, Leo Anthony Celi, Simone Kreth, Shahnaz Christina Azad
AIM: Pain therapy is strongly guided by patients' self-reporting. However, when self-reporting is not an option, pain assessment becomes a challenge and may lead to undertreatment of painful conditions. Pain is a complex and multifactorial phenomenon. Recent work has connected pain pathophysiology also with the inflammatory system. We therefore hypothesized that pain intensity could be predicted by cytokine-levels. PATIENTS & METHODS: In this observational, single-center study, we investigated 30 serum cytokines to predict pain intensity in a screening/follow-up set of 95 chronic pain patients and controls...
March 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28240096/role-of-%C3%AE-2-microglobulin-in-postoperative-cognitive-decline
#17
Marta Załęska-Kocięcka, Paweł Jezierski, Maciej Grabowski, Krzysztof Kuśmierski, Maciej Dąbrowski, Katarzyna Piotrowska, Marek Banaszewski, Jacek Imiela, Janina Stępińska
AIM: β2-microglobulin (β2M) was proved to affect hippocampal functions in mice. MATERIALS & METHODS: Seventy-one patients undergoing aortic valve replacement were analyzed in prospective observational study. Kidney biomarkers and Mini Mental State Examinations (MMSEs) were performed before procedure, at discharge and after 6 months. RESULTS: Patients with β2M increase over the median change (>0.42 mg/l) experienced a significant in-hospital drop in MMSE (p = 0...
March 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28157383/biomarkers-of-oxidative-stress-in-pregnancy-complications
#18
James Sm Cuffe, Ziheng Calvin Xu, Anthony V Perkins
Pregnancy complications including pre-eclampsia, gestational-diabetes mellitus, preterm birth and intrauterine growth restriction can cause acute and chronic health problems for the mother and lead to fetal loss or dysregulation of infant physiology. The human placenta is susceptible to oxidative stress and oxidative damage in early gestation contributes to the onset of these conditions later in pregnancy. Current methods of predicting pregnancy complications are limited and although a large number of factors are associated with disease progression, few biomarkers have been used to aid in disease diagnosis early in gestation...
March 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28157397/association-of-red-cell-distribution-width-with-noninfarct-related-artery-chronic-total-occlusion-in-acute-myocardial-infarction-patients
#19
Mikail Yarlioglues, Alparslan Kurtul
OBJECTIVE: The presence of chronic total occlusion (CTO) in noninfarct-related artery (non-IRA) is an independent predictor of mortality in acute myocardial infarction (AMI). We investigated whether red cell distribution width (RDW) levels are associated with presence of non-IRA-CTO in AMI (ST-elevation myocardial infarction [STEMI] and non-STEMI). PATIENTS AND METHODS: Patients (n = 858) were categorized into three groups: single vessel disease, multivessel disease (MVD) without CTO and MVD with CTO...
February 3, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28157385/enhanced-s100a9-and-s100a12-expression-in-acute-coronary-syndrome
#20
Zafer Buyukterzi, Ummugulsum Can, Sertac Alpaydin, Asuman Guzelant, Sukru Karaarslan, Duygu Kocyigit, Kadri Murat Gurses
AIMS: In this study, we aimed to investigate whether serum S100A8, S100A9 and S100A12 levels were markers of acute coronary syndrome (ACS). MATERIALS & METHODS: Patients who underwent coronary angiography and/or percutaneous coronary interventions between June 2015-October 2015 were consecutively recruited in this study and categorized three groups each containing 30 patients (normal coronary arteries, stable coronary artery disease, and acute coronary syndrome)...
February 3, 2017: Biomarkers in Medicine
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