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Biomarkers in Medicine

Demosthenes E Ziogas, Ioannis D Kyrochristos, Efstathios G Lykoudis, Dimitrios H Roukos
No abstract text is available yet for this article.
October 31, 2018: Biomarkers in Medicine
Martina Rosticci, Natalia Pervjakova, Marika Kaakinen, Arrigo F Cicero, Arne P Feufer, Letizia Marullo, Reedik Mägi, Krista Fischer, Longda Jiang, Sergio D'Addato, Elisabetta Rizzoli, Gianmichele Massimo, Marina Giovannini, Sabrina Angelini, Patrizia Hrelia, Chiara Scapoli, Claudio Borghi, Inga Prokopenko
AIM: The aim of the study was to explore the effects of variants at 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and kinesin family member 6 (KIF6) loci on a range of cardio-metabolic phenotypes. METHODS: We analyzed the range of variants within Genetics in Brisighella Health Study and KIF6 genes using an additive genetic model on 18 cardiometabolic phenotypes in a sample of 1645 individuals from the Genetics in Brisighella Health Study and replicated in 10,662 individuals from the Estonian Genome Center University of Tartu...
September 7, 2018: Biomarkers in Medicine
Chunmeng Wei, Yasi Li, Kaiming Huang, Gang Li, Min He
AIM: The aim was to systematically evaluate whether exosomal miRNAs could be regarded as potential minimally invasive biomarkers of diagnosis for gastrointestinal cancer. METHODS: A systematic review and meta analysis of exosomal miRNA expression in gastrointestinal cancer were performed. RESULTS: A total of 370 articles were retrieved from PubMed and EMBASE. The summary receiver operating characteristic curves of three miRNAs (miR-21, miR-1246 and miR-4644) were drawn, miR-21, miR-1246 and miR-4644 exhibited sensitivities of 0...
October 2018: Biomarkers in Medicine
Federico Carbone, Fabrizio Montecucco
No abstract text is available yet for this article.
October 2018: Biomarkers in Medicine
Raffaello Molino Lova, Cristina Vassalle, Elisabetta Masini, Silvia Del Ry, Manuela Cabiati, Guido Pasquini, Claudio Macchi
AIM: To explore possible inter-relationships of various biomarkers of inflammation and lifestyle and other cardiovascular risk factors (age, gender, smoking history, hypertension, Type 2 diabetes, dyslipidemia, alteration of circadian rhythms, body mass index, calf circumference, thigh circumference, abdominal circumference) in the Mugello study oldest old. METHODS: In 399 noninstitutionalized nonagenarians (291 women), whole blood cells, mean platelet volume, C-reactive protein, uric acid, gamma-glutamyl transferase were assessed...
October 2018: Biomarkers in Medicine
Panagiotis Paliogiannis, Alessandro G Fois, Claudia Collu, Antonietta Bandinu, Elisabetta Zinellu, Ciriaco Carru, Pietro Pirina, Arduino A Mangoni, Angelo Zinellu
AIM: The aim of this meta-analysis was to investigate associations between idiopathic pulmonary fibrosis (IPF) and markers of oxidative stress (OS) measured in different biological samples. METHODS: A systematic search of publications listed in PubMed, Web of Science, Scopus and Google Scholar from inception to December 2017 was conducted. RESULTS: Significant differences between IPF patients and controls were observed for all biomarkers (thiobarbituric acid reactive substances, hydroperoxides and glutathione), barring systemic isoprostanes...
October 2018: Biomarkers in Medicine
Mustafa Aytek Simsek, Muzaffer Degertekin, Ayca Turer Cabbar, Emre Aslanger, Olcay Ozveren, Sinan Aydın, Bulent Mutlu, Cetin Erol
AIM: We investigated the relationship between NT-ProBNP and mortality in a general population-based cohort. METHODS & RESULTS: A total of 2021 out of 4650 participants from previously published HAPPY study were included. Mean follow-up was 84.5 ± 10.4 months. After adjusting for risk factors, high levels of LogNT-proBNP predicted all-cause death (HR: 3.23; 95% CI: 2.20-4.75; p < 0.001) and cardiovascular death (HR: 3.85; 95% CI: 2.37-6.26; p < 0...
October 2018: Biomarkers in Medicine
Seema Khadirnaikar, Sathiya Pandi Narayanan, Sudhanshu Kumar Shukla
AIM: LncRNAs may act as promising biomarkers in esophageal cancer (EC). Here, we illustrate the LncRNA profile and their clinical relevance in EC. PATIENTS & METHODS: In this study, we utilized the Cancer Genome Atlas RNA-sequencing and clinical data from 186 patients and 13 normal samples. Various statistical and gene set enrichment analysis (GSEA) were performed to identify the biomarkers. RESULTS: In a differential expression analysis, we identified a total of 127 LncRNAs with more differentially expressed in EC compared with normal and showed their function using guilt-by-association analysis...
October 2018: Biomarkers in Medicine
Monireh Mohsenzadegan, Fatemeh Saebi, Mehdi Yazdani, Maryam Abolhasani, Nazanin Saemi, Fatemeh Jahanbani, Mohammad M Farajollahi
AIM: We assessed an autoantibody against new gene expressed in prostate (NGEP) protein for prostate cancer (PCa) that may better diagnosis and prognosis approaches in the patients with PCa. METHODS: Autoantibodies against NGEP were measured in sera of PCa patients by ELISA. RESULTS: The autoantibody against NGEP is present in a significantly higher proportion in the sera of PCa patients as compared with healthy controls (p < 0.001). An inverse significant correlation was found between seropositive patients and Gleason score (p < 0...
October 2018: Biomarkers in Medicine
Iftikhar Ahmed, Zafar Niaz, Frederick Ewbank, Danyal Akarca, Richard Felwick, Manuele Furnari
Distinct changes can be observed in the odor of human excretions during health and disease. Identifying underlying volatile metabolites responsible for these odorous changes can be correlated with the pathological process within the body. Advances in the technology have enabled us to interpret the volatile signature of these changes in the odor. This has opened a promising area to lay the foundations of a rapid, noninvasive and point of care diagnostic tool. This review explores the diagnostic potential of volatile organic metabolites as novel biomarkers and extends the discussion on the clinical applications of these biomarkers in gastrointestinal disorders...
October 2018: Biomarkers in Medicine
Mauro Maniscalco, Debora Paris, Mauro Carone, Antonio Spanevello, Michele Vitacca, Andrea Motta
No abstract text is available yet for this article.
October 2018: Biomarkers in Medicine
Xi-Fen Liu, Lin-Ying Zhou, Zi-Hao Wei, Jia-Xin Liu, Ang Li, Xiao-Zhong Wang, Hou-Qun Ying
AIM: To investigate the diagnostic roles of circulating inflammatory biomarkers in gallbladder carcinoma (GBC). PATIENTS & METHODS: Circulating inflammatory cell count, fibrinogen, albumin, carcinoembryonic antigen (CEA) and CA199 were measured, neutrophil-to-lymphocyte ratio (NLR), dNLR, PLR, LMR and Alb-to-fib (AFR) were calculated in 306 GBC patients, 306 healthy and 305 benign controls. The reciever operating characteristic curve was used to determine diagnostic accuracy of them...
October 2018: Biomarkers in Medicine
Jun Sik Yoon, Gyeonghwa Kim, Yu Rim Lee, Soo Young Park, Won Young Tak, Young-Oh Kweon, Jung Gil Park, Hye Won Lee, Young Seok Han, Heon Tak Ha, Jae Min Chun, Se Young Jang, Keun Hur
AIM: Aberrant microRNA (miR) expression is associated with hepatocellular carcinoma (HCC). MATERIALS & METHODS: Here, we investigated the clinical significance of miR-21 and miR-31 for HCC-specific prognostic effect. HCC patients (n = 93) who underwent liver biopsy or surgical resection were enrolled, and HCC tissues and paired adjacent nontumor liver tissues were collected and analyzed for miRs expression. RESULTS: MiR-21 expression was significantly upregulated in HCC tissues relative to nontumor tissues...
October 2018: Biomarkers in Medicine
Braira Wahid, Shazia Rafique, Amjad Ali, Muhammad Waqar, Ghulam Nabi, Muhammad Wasim, Muhammad Idrees
Gynecological disorders are leading public health problems in developing countries with substantial impact on women's quality of life. Significant proportion of maternal mortality and reproductive morbidity is attributed to misdiagnosis and mismanagement of pregnancy related lethal pathological conditions and affect women's health. Timely diagnosis is necessary to prevent maternal deaths and to manage complications. Biomarker development will create a wide window of opportunity for early diagnosis. This review discusses the current status of biomarkers and recent advances in 'omics' technology for early screening of endometriosis and pre-eclampsia because of significant global bioburden associated with these disorders...
October 2018: Biomarkers in Medicine
Qian Huang
Radiotherapy is one of the most commonly used methods to treat non-small-cell lung cancer. However, radiotherapy, especially thoracic radiotherapy, is always accompanied by radiation-induced complications or radioresistance. In this regard, ncRNAs, including miRNAs and lncRNAs, have received considerable interest for their predictive relevance. This review article illustrates the recent findings about the possible involvement of ncRNAs, mainly miRNAs and lncRNAs, in radioresistance and radiation-induced complications and their potential use for predicting radiation-induced complications and radiotherapy response...
October 2018: Biomarkers in Medicine
Raffaele Serra, Nicola Ielapi, Andrea Barbetta, Michele Andreucci, Stefano de Franciscis
Cardiovascular disease refers to different diseases involving the heart and/or the arteries and/or the veins. Cardiovascular disease, overall considered, is a notable source of morbidity and mortality worldwide. Therefore, several research studies are dedicated to explore, by means of biomarkers, the possiblity to calculate the cardiovascular risk both for the onset and for the complications of the related clinical manifestations such as coronary artery disease, carotid artery stenosis, peripheral artery disease, arterial aneurysm, chronic venous disease and venous thromboembolism...
September 2018: Biomarkers in Medicine
Christian Albert, Annemarie Albert, Rinaldo Bellomo, Siegfried Kropf, Prasad Devarajan, Sabine Westphal, Hassina Baraki, Ingo Kutschka, Christian Butter, Michael Haase, Anja Haase-Fielitz
AIM: To assess weather doctors' clinical risk-assessment for major adverse kidney events (MAKE) and acute kidney injury (AKI) after open-heart surgery would improve when being informed about neutrophil gelatinase-associated lipocalin (NGAL) test result at ICU admission. PATIENTS & METHODS: Clinical risk-assessment for MAKE and AKI were performed with and without providing NGAL test result and compared in an exploratory- and a validation-cohort using reclassification metrics, exemplary category-free net reclassification improvement (cfNRI)...
September 2018: Biomarkers in Medicine
Lele Song, Shaohua Guo, Jiayu Wang, Xiumei Peng, Jia Jia, Yuan Gong, Bo Yang, Wenhua Xiao, Cheng Dong, Hongyi Liu, Yuemin Li
AIM: To investigate the performance of methylated SEPT9 (mSEPT9) in assessing the surgical therapeutic effect and prognosis of colorectal cancer (CRC). METHODS: Blood samples before surgery and 1 and 7 days after surgery were obtained from 120 CRC patients, and mSEPT9 and carcinoembryonic antigen (CEA) assays were performed. RESULTS: The mean plasma mSEPT9 level showed 57.6-times and 131.1-times decrease 1 day and 7 days after surgery, respectively...
September 2018: Biomarkers in Medicine
Wei Zhang, Hong Chen, Zhihui Sun, Chengyu Qiu, Jingjie Xiao, Wenli Luo, Da Liu, Zhitao Yan, Huajing Ou, Xiaoman Wen, Ganxiong Li, Gang Huang
AIM:  Notch1 expression remains controversial on digestive tract cancers. This meta-analysis was performed to assess the clinicopathological significance of Notch1 expression in individuals with digestive tract cancers, mainly involving esophageal squamous cell carcinoma (ESCC), gastric cancer (GC), pancreatic cancer (PC) and colorectal cancer (CRC). METHODS: Available articles were searched from the online databases, and the meta-analysis was done using Review Manager software 5...
September 2018: Biomarkers in Medicine
Jessika González-D'Gregorio, Gema Miñana, Julio Núñez, Eduardo Núñez, Vicente Ruiz, Sergio García-Blas, Clara Bonanad, Anna Mollar, Ernesto Valero, Martina Amiguet, Clara Sastre, Juan Sanchis
AIM: We evaluated the relationship between iron deficiency (ID) and long-term mortality risk in elderly patients with acute coronary syndrome (ACS). METHODS: In this prospective observational study, we included 252 patients older than 65 years with ACS. Transferrin saturation (TSAT) and ferritin were collected before discharge. RESULTS: Mean age, hemoglobin and GRACE score were 78 ± 7 years, 12.4 ± 1.8 g/dl and 138.8 ± 25.3, respectively, 112(44...
September 2018: Biomarkers in Medicine
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