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Biomarkers in Medicine

Mario C Deng
Heart failure (HF) is a complex clinical syndrome that causes systemic hypoperfusion and failure to meet the body's metabolic demands. In an attempt to compensate, chronic upregulation of the sympathetic nervous system and renin-angiotensin-aldosterone leads to further myocardial injury, HF progression and reduced O2 delivery. This triggers progressive organ dysfunction, immune system activation and profound metabolic derangements, creating a milieu similar to other chronic systemic diseases and presenting as advanced HF with severely limited prognosis...
May 8, 2018: Biomarkers in Medicine
Yanjiao Ren, Xin Feng, Xin Xia, Yexian Zhang, Wenniu Zhang, Jing Su, Zhongyu Wang, Ying Xu, Fengfeng Zhou
AIM: The two genders are different ranging from the molecular to the phenotypic levels. But most studies did not use this important information. We hypothesize that the integration of gender information may improve the overall prediction accuracy. MATERIALS & METHODS: A comprehensive comparative study was carried out to test the hypothesis. The classification of the stages I + II versus III + IV of the clear cell renal cell carcinoma samples was formulated as an example...
April 30, 2018: Biomarkers in Medicine
Juan Gabriel Costa, María Julia Vilariño
A key element in any diagnostic technique is the antigen (Ag), a biomarker, but this is usually a protein that has a function to the parasite. Some biological aspects of the Ags and of the Toxoplasma gondii can influence the effectiveness of the diagnosis, as well as the antibody isotype and the characteristics of the assay. A large number of papers have assessed different proteins to distinguish the phases of infection, but the 'indices of effectiveness' differ among reports. This work presents for the first time a summary of all the Ags that have been evaluated, with standardized measurements of sensitivity and specificity...
April 26, 2018: Biomarkers in Medicine
Weimin Kong, Simon F Lacey, Jan Joseph Melenhorst, Joseph A Fraietta
No abstract text is available yet for this article.
April 26, 2018: Biomarkers in Medicine
Carlos A Castaneda, Miluska Castillo, Luis A Bernabe, Joselyn Sanchez, Sandro Casavilca, Pamela García-Corrochano, Jaime Ponce, Maria R Villa-Robles, Carolina Belmar Lopez, Enrique Orrego
AIM: To evaluate the prognostic value of tumor-infiltrating lymphocytes (TILs) and Ki67 in brain metastasis lesions, and the effect of adding them to variables of graded prognostic assessment score. PATIENTS & METHODS: Clinicopathological information from 111 medical charts of brain metastasis patients was obtained, and TIL distribution (n = 84), Ki67 index (n = 79) and CD3 TIL (n = 64) were prospectively evaluated. RESULTS: Most frequent TIL pattern was perivascular (67...
April 26, 2018: Biomarkers in Medicine
Tulantched Mingina, Min Zhao
AIM: Biomarkers are molecules measured in plasma, serum or other body fluids to characterize a disease. PARK7 and NDKA roles in the management of stroke are still on study. Therefore, their potentials need to be developed in totality. The aim of this review is to demonstrate that PARK7 and NDKA could present more clinical important information as biomarkers for management of stroke disease. Main contents: Four main aspects of PARK7 and NDKA are exploited in this review. First, their diagnostic value is discussed in order to demonstrate their possible role as stroke diagnosis markers...
April 26, 2018: Biomarkers in Medicine
Pierre Galichon, Yi-Chun Xu-Dubois, David Buob, Claire Tinel, Dany Anglicheau, Sabrina Benbouzid, Karine Dahan, Nacera Ouali, Alexandre Hertig, Isabelle Brocheriou, Eric Rondeau
AIM: Subclinical pathological features in renal allograft biopsies predict poor outcomes, and noninvasive biomarkers are wanted. RNA quantification in urine predicts overt rejection. We hypothesized that a whole transcriptome analysis would be informative, even for discrete injury. PATIENTS & METHODS: We performed an mRNA microarray with an optimized normalization method on 26 urinary cell pellets to study renal partial epithelial to mesenchymal transition (pEMT) in stable kidney allografts...
April 26, 2018: Biomarkers in Medicine
Luigi M Casello, Livia Salmi, Isabella Zanotti, Clara A Gardino, Marco Baldrighi, Fabio Settanni, Gian C Avanzi
AIM: To investigate the copeptin prognostic role in mild head trauma. METHODS: We enrolled 105 adult patients who entered the emergency room because of recent mild head trauma; we evaluated: clinical picture, imaging and laboratory data (including copeptin). RESULTS: Copeptin resulted higher in mild head trauma patients compared with controls: 29.89 pmol/l versus 7.05 pmol/l; (p = 0.0008). Copeptin failed in identifying patients with or without brain lesions detected by CT scan, and patients with or without adverse events during the 30 days follow-up...
April 5, 2018: Biomarkers in Medicine
Yaoxian Lou, Yassi Fallah, Kellie Yamane, Patricia E Berg
Homeobox genes are critical in tumor development. An isoform protein of DLX4 called BP1 is expressed in 80% of invasive ductal breast carcinomas. BP1 overexpression is implicated in an aggressive phenotype and poor prognosis. BP1 upregulation is associated with estrogen receptor negativity so those tumors do not respond to antiestrogens. Breast cancer is the second leading cause of death in women. BP1 could serve as both a novel prognostic biomarker for breast cancer and a therapeutic target. In this review, we address the role of BP1 protein in tumorigenesis of breast cancer and four other malignancies...
March 26, 2018: Biomarkers in Medicine
Shucai Liang, Lulin Chang
AIM: To comprehensively evaluate the diagnostic value of serum matrix metalloproteinase-9 (MMP-9) level for colorectal cancer (CRC). METHODS: Both of the relationships between MMP-9 level and CRC and the diagnostic value were evaluated from 12 eligible papers. RESULTS: The high MMP-9 level increased CRC risk. The estimated sensitivity and specificity were 69 and 68%, respectively, which signified that the diagnostic value was medium. Diagnostic odds ratio and the area under the receiver operating characteristic curve suggested MMP-9 level has a moderate diagnostic value in CRC...
March 26, 2018: Biomarkers in Medicine
Qian Wang, Yan Meng, Wenyan Cao, Wenjing Du, Yumei Liu, Yi Yan, Li Luo, Xiumin Ma
AIM: The purpose of this study was to evaluate the relationship between Monocyte to high-density lipoprotein cholesterol ratio (MHR) and carotid atherosclerostic plaque in patients with systemic lupus erythematosus (SLE). METHODS: A total of 214 SLE patients were divided into two groups according to the results of ultrasonic examination: carotid arterial atherosclerotic plaque groups and noncarotid arterial atherosclerosis groups. RESULTS: The values of monocyte to high-density lipoprotein-cholesterol ratio (MHR) increase in carotid arterial atherosclerotic plaque groups compared with noncarotid arterial atherosclerosis groups (0...
March 23, 2018: Biomarkers in Medicine
Cristina Vassalle, Antonella Meloni, Laura Pistoia, Maria Rita Gamberini, Anna Spasiano, Calogera Gerardi, Angelo Zuccarelli, Tommaso Casini, Riccardo Righi, Massimiliano Missere, Vincenzo Positano, Rudina Ndreu, Alessia Pepe
AIM: to evaluate the relationship between uric acid (UA), hepatic and cardiac iron overload (T2*-MRI), ferritin, endocrinological diseases and cardiac complications in a large thalassemia major (TM) cohort. METHODS:  A total of 369 TM patients (187 men; 33 ± 6 years) were retrospectively studied, from the myocardial iron overload in thalassemia (MIOT) electronic databank. RESULTS: Multiple regression model identified male sex (p < 0...
March 23, 2018: Biomarkers in Medicine
Jason E Sandler, Meghan Kaumaya, Balazs Halmos
No abstract text is available yet for this article.
March 23, 2018: Biomarkers in Medicine
Daniela V Rosa, Luiz A Magno, Nathália Cm Pereira, Luiz C Romanelli, Maicon R Albuquerque, Marina L Martins, Anna B de Freitas Carneiro Proietti, Rodrigo Nicolato, Ana C Simões E Silva, Debora M de Miranda
AIM: The aim of this study is to evaluate the presence of a particular immunological profile in individuals long-term infected with HTLV-1, followed presenting different clinical courses. MATERIALS & METHODS: Forty-eight individuals were evaluated for 19 cytokines analyzed in cerebrospinal fluid and plasma of patients with HTLV-1 presenting with and without neurological symptoms. RESULTS: Proinflammatory cytokines and the chemokine ligand 11 (ITAC/CXCL11) were increased in individuals with HTLV-1 coursing with neurological symptoms...
May 2018: Biomarkers in Medicine
Yun Qiu, Sufan Wang, Ting Wan, Mingtong Ye, Rui Jiang, Lei Pei, Lili Yang
Nonalcoholic fatty liver disease has become a social health challenge of global concern. The term nonalcoholic steatohepatitis (NASH) is a more severe condition than simple steatosis and distinguishing NASH from nonalcoholic fatty liver disease is particularly important. Liver biopsy remains a gold standard in diagnosing NASH. Meanwhile, radiological techniques such as ultrasonography and MRI are also applied widely. However, the invasive and expensive examination is not suitable for screening, and there is a great need for reliable and appropriate biomarkers to screen patients for NASH...
May 2018: Biomarkers in Medicine
Khalid Siddiqui, Salini S Joy, Shumaila Ilias, Haya S Alzeer, Khalid Al-Rubeaan
For better identification of novel diagnostic urinary biomarker in Type 2 diabetic nephropathy (T2DN), methodological and reporting quality is as important as validity of biomarkers. The aim of this systematic review is to find out the best-reported diagnostic urinary biomarkers study in T2DN based on STARD criteria. We also analyzed the validity of urinary markers in the selected articles those followed STARD criteria. The diagnostic accuracy of urinary biomarkers on T2DN is not conclusive because of the poor reporting quality and differences in adjustment for conventional risk factors...
May 2018: Biomarkers in Medicine
N Pervjakova, V Kukushkina, T Haller, S Kasela, A Joensuu, K Kristiansson, T Annilo, M Perola, V Salomaa, P Jousilahti, A Metspalu, R Mägi
AIM: The aim of the study was to explore the parent-of-origin effects (POEs) on a range of human nuclear magnetic resonance metabolites. MATERIALS & METHODS: We search for POEs in 14,815 unrelated individuals from Estonian and Finnish cohorts using POE method for the genotype data imputed with 1000 G reference panel and 82 nuclear magnetic resonance metabolites. RESULTS: Meta-analysis revealed the evidence of POE for the variant rs1412727 in PTPRD gene for the metabolite: triglycerides in medium very low-density lipoprotein...
May 2018: Biomarkers in Medicine
Ender Ornek, Mustafa Cetin, Emrullah Kiziltunc, Alparslan Kurtul, Murat Gok, Harun Kundi
AIM: Procalcitonin (PCT) is an inflammatory marker and elevated PCT levels are associated with cardiovascular events. We assessed whether PCT level is an independent predictor of bare-metal stent (BMS) in-stent restenosis (ISR). PATIENTS & METHODS: We evaluated 240 patients undergoing BMS implantation. Serum PCT levels were measured before procedure. Patients were classified as ISR(-) group (n = 120) and ISR(+) group (n = 120). RESULTS: Serum PCT levels were higher in the ISR (+) group (p < 0...
May 2018: Biomarkers in Medicine
Piyaporn Karuwanarint, Benjaluck Phonrat, Anchalee Tungtrongchitr, Kanjana Suriyaprom, Somlak Chuengsamarn, Florian J Schweigert, Rungsunn Tungtrongchitr
AIM: To investigate the relationship of vitamin D-binding protein (GC) and genetic variation of GC (rs4588, rs7041 and rs2282679) with metabolic syndrome (MetS) in the Thai population. MATERIALS & METHODS: GC-globulin concentrations were measured by quantitative western blot analysis in 401 adults. All participants were genotyped using TaqMan allelic discrimination assays. RESULTS: GC-globulin levels were significatly lower in MetS subjects than in control subjects, in which significant negative correlations of GC-globulin levels with systolic blood pressure, glucose and age were found...
May 2018: Biomarkers in Medicine
Yi-Tong Wei, Yu-Zhong Luo, Zhi-Qiang Feng, Qiang-Xin Huang, An-Sheng Mo, Shao-Xiong Mo
The study aimed to unveil the effect of TK1 expression on the clinicopathological significance and prognosis in patients with lung cancer. Results & methodology: Studies for meta-analysis were selected according to a thorough literature search in databases (PubMed, EMBASE and Chinese databases). Ten studies containing 1393 lung cancer patients were investigated in our analysis. The TK1 overexpression was associated with poorer overall survival(OS) in lung cancer patients (hazard ratio = 1.881; 95% CI:1...
April 2018: Biomarkers in Medicine
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