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Biomarkers in Medicine

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https://www.readbyqxmd.com/read/28157397/association-of-red-cell-distribution-width-with-noninfarct-related-artery-chronic-total-occlusion-in-acute-myocardial-infarction-patients
#1
Mikail Yarlioglues, Alparslan Kurtul
OBJECTIVE: The presence of chronic total occlusion (CTO) in noninfarct-related artery (non-IRA) is an independent predictor of mortality in acute myocardial infarction (AMI). We investigated whether red cell distribution width (RDW) levels are associated with presence of non-IRA-CTO in AMI (ST-elevation myocardial infarction [STEMI] and non-STEMI). PATIENTS AND METHODS: Patients (n = 858) were categorized into three groups: single vessel disease, multivessel disease (MVD) without CTO and MVD with CTO...
February 3, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28157385/enhanced-s100a9-and-s100a12-expression-in-acute-coronary-syndrome
#2
Zafer Buyukterzi, Ummugulsum Can, Sertac Alpaydin, Asuman Guzelant, Sukru Karaarslan, Duygu Kocyigit, Kadri Murat Gurses
AIMS: In this study, we aimed to investigate whether serum S100A8, S100A9 and S100A12 levels were markers of acute coronary syndrome (ACS). MATERIALS & METHODS: Patients who underwent coronary angiography and/or percutaneous coronary interventions between June 2015-October 2015 were consecutively recruited in this study and categorized three groups each containing 30 patients (normal coronary arteries, stable coronary artery disease, and acute coronary syndrome)...
February 3, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28157383/biomarkers-of-oxidative-stress-in-pregnancy-complications
#3
James Sm Cuffe, Ziheng Calvin Xu, Anthony V Perkins
Pregnancy complications including pre-eclampsia, gestational-diabetes mellitus, preterm birth and intrauterine growth restriction can cause acute and chronic health problems for the mother and lead to fetal loss or dysregulation of infant physiology. The human placenta is susceptible to oxidative stress and oxidative damage in early gestation contributes to the onset of these conditions later in pregnancy. Current methods of predicting pregnancy complications are limited and although a large number of factors are associated with disease progression, few biomarkers have been used to aid in disease diagnosis early in gestation...
February 3, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28156128/long-term-prognostic-role-of-ca-125-in-noncongestive-patients-undergoing-a-cardiac-transplantation
#4
Víctor Manuel Becerra-Muñoz, José Manuel Sobrino-Márquez, Diego Rangel-Sousa, Agustín Fernández-Cisnal, Ernesto Lage-Gallé, José Manuel García-Pinilla, Ángel Martínez-Martínez, Eduardo de Teresa-Galván
AIM: To evaluate the possible relationship between high levels of CA-125 and long-term prognosis in chronic heart failure patients after they undergo a cardiac transplantation (CT). MATERIALS & METHODS: We retrospectively studied all patients who underwent a CT and had a previous determination of CA-125. Congestive patients and those whose survival was <1 year after CT were excluded. RESULTS: Of 55 patients, 23 had elevated CA-125 levels (>35 U/ml)...
February 3, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28150509/potential-diagnostic-and-prognostic-significance-of-plasma-prolidase-activity-in-gastric-cancer
#5
Sebahattin Celik, Remzi Kızıltan, Eyüp M Yılmaz, Özkan Yılmaz, Halit Demir
AIM: Plasma prolidase activities (PPAs) in cases of gastric cancer. METHODOLOGY/RESULTS: This study was based on a prospective design. 60 patients with gastric cancer (operable cases: 48; inoperable: 12) and 60 healthy controls were included in the study. Prolidase activity was analyzed. The mean PPA levels in the operable, inoperable and control groups were 45.60 ± 4.20, 54.35 ± 4. 9 and 10.92 ± 0.79 U/l, respectively (p < 0.001). PPA decreased significantly after tumor resection...
February 2, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28092449/long-noncoding-rna-as-an-indicator-differentiating-schizophrenia-from-major-depressive-disorder-and-generalized-anxiety-disorder-in-nonpsychiatric-hospital
#6
Xuelian Cui, Wei Niu, Lingming Kong, Mingjun He, Kunhong Jiang, Shengdong Chen, Aifang Zhong, Qiaoli Zhang, Wanshuai Li, Jim Lu, Liyi Zhang
AIM: Depression and anxiety are common symptoms for schizophrenia (SZ) in the early onset. This study aimed to determine whether long noncoding RNAs (lncRNAs) can be indicators for diagnosing SZ in nonpsychiatric hospitals. MATERIALS & METHODS: Three upregulated SZ lncRNAs, six downregulated major depressive disorder (MDD) lncRNAs and three upregulated generalized anxiety disorder (GAD) lncRNAs were cross-validated in 45 SZ patients, 48 MDD patients, 52 GAD patients and 40 controls by reverse transcription-PCR...
January 16, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28125293/mirnas-as-biomarkers-of-neurodegenerative-disorders
#7
Vijitha Viswambharan, Ismail Thanseem, Mahesh M Vasu, Suresh A Poovathinal, Ayyappan Anitha
Neurodegenerative diseases (NDDs) are the result of progressive deterioration of neurons, ultimately leading to disabilities. There is no effective cure for NDDs at present; ongoing therapies are mainly aimed at treating the most bothersome symptoms. Since early treatment is crucial in NDDs, there is an urgent need for specific and sensitive biomarkers that can aid in early diagnosis of these disorders. Recently, altered expression of miRNAs has been implicated in several neurological disorders, including NDDs...
February 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28111965/identification-of-cd4-t-cell-derived-cd161-cd39-and-cd39-cd73-microparticles-as-new-biomarkers-for-rheumatoid-arthritis
#8
Wenqiang Fan, Wenxiang Wang, Jie Wu, Ling Ma, Jinyan Guo
AIM: This study aimed to identify CD4(+) T-cell-derived microparticles (MPs) and investigate their roles in rheumatoid arthritis (RA). METHODS: Synovial fluids from 34 RA, 33 osteoarthritis patients and 42 healthy individuals were analyzed by flow cytometry. Human fibroblast-like synoviocytes and peripheral blood mononuclear cells were cultured with or without isolated MPs, chemokines and cytokines were measured by ELISA. RESULTS: CD4(+)CD161(+)CD39(+) and CD4(+)CD39(+)CD73(+) MPs were abundantly present in RA patients, which were positively or negatively correlated with RA features, respectively...
February 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28111964/association-between-c-reactive-protein-levels-in-the-first-1-3-days-post-transplant-and-allogeneic-immune-reactions
#9
Yao Chen, Xiao-Jun Huang, Kai-Yan Liu, Huan Chen, Yu-Hong Chen, Xiao-Hui Zhang, Yu Wang, Feng-Rong Wang, Wei Han, Jing-Zhi Wang, Chen-Hua Yan, Lan-Ping Xu
AIM: The purpose of this study was to determine whether C-reactive protein (CRP) in the first 1-3 days post-transplant could predict allogeneic immune reactions, including engraftment syndrome or acute graft-versus-host disease (GVHD), in pediatric haploidentical stem cell transplantation. PATIENTS & METHODS: The study population comprised 175 consecutive pediatric patients. Receiver operating characteristic analysis was performed to identify the cut-off CRP value...
February 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28111962/selecting-a%C3%AE-isoforms-for-an-alzheimer-s-disease-cerebrospinal-fluid-biomarker-panel
#10
Charisse Somers, Joery Goossens, Sebastiaan Engelborghs, Maria Bjerke
Although the core cerebrospinal fluid Alzheimer's disease (AD) biomarkers amyloid-β (Aβ1-42) and tau show a high diagnostic accuracy, there are still limitations due to overlap in the biomarker levels with other neurodegenerative and dementia disorders. During Aβ1-42 production and clearance in the brain, several other Aβ peptides and amyloid precursor protein fragments are formed that could potentially serve as biomarkers for this ongoing disease process. Therefore, this review will present the current status of the findings for amyloid precursor protein and Aβ peptide isoforms in AD and clinically related disorders...
February 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28097894/high-serum-ykl-40-level-positively-correlates-with-coronary-artery-disease
#11
Yan Jin, Jia-Ning Cao, Chun-Xia Wang, Qiu-Ting Feng, Xin-He Ye, Xin Xu, Cheng-Jian Yang
AIM: We investigated the predictive value of chitinase-like protein YKL-40 in coronary artery disease (CAD). PATIENTS: Serum YKL-40 levels in 116 CAD patients and 82 healthy controls were analyzed. Severity of CAD was evaluated using Gensini scores. Spearman's correlation was used to evaluate the correlation between Gensini scores and YKL-40 levels. The predictive value of YKL-40 was determined by receivers operating characteristic curve analysis. RESULTS: Serum YKL-40 levels were significantly elevated in CAD group as compared with control group...
February 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28097885/transformative-biomarkers-for-drug-induced-liver-injury-are-we-there-yet
#12
Daniel J Antoine, James W Dear
No abstract text is available yet for this article.
February 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28097884/the-pretreatment-thrombocytosis-may-predict-prognosis-of-patients-with-colorectal-cancer-a-systematic-review-and-meta-analysis
#13
Yong-Hong Wang, Shao-Jun Deng, Yong-Dong Yang, Nan Yao, Jian-Meng Zhao, Guang-Tao Min, Jun Wang, Teng-Fei Xu, Peng-Ying Zhao, Hong-Peng Wang, Wei Chen
AIM: Recently, several studies have reported that thrombocytosis may be associated with the poor prognosis of colorectal cancer (CRC). Nevertheless, their conclusions were still controversial. Results & methodology: We searched PubMed, Embase, Cochrane Library and Web of Science up to April 2016. A total of 30 studies including 9129 patients were included in this meta-analysis. Thrombocytosis had a close relationship with the poor overall survival of CRC compared with normal platelet counts, with the pooled hazard ratios being 1...
February 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28097879/metabolomics-biomarkers-for-tuberculosis-diagnostics-current-status-and-future-objectives
#14
Ilse du Preez, Laneke Luies, Du Toit Loots
Numerous studies have contributed to our current understanding of the complex biology of pulmonary tuberculosis and subsequently provided solutions to its control or eradication. Metabolomics, a newcomer to the Omics research domain, has significantly contributed to this understanding by identifying biomarkers originating from the disease-associated metabolome adaptations of both the microbe and host. These biomarkers have shed light on previously unknown disease mechanisms, many of which have been implemented toward the development of improved diagnostic strategies...
February 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28097875/mirna-profiling-for-the-early-detection-and-clinical-monitoring-of-diabetic-kidney-disease
#15
Johanna K DiStefano
No abstract text is available yet for this article.
February 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/27929666/association-between-il-27-gene-polymorphisms-and-risk-of-papillary-thyroid-carcinoma
#16
Xinwen Nie, Fang Yuan, Peng Chen, Yan Pu, Jingqiang Zhu, Yichao Wang, Xue Xiao, Guanglu Che, Linbo Gao, Lin Zhang
AIM: IL-27 has potent antitumor effects. We aimed to examine the contribution of single nucleotide polymorphisms in IL-27 to the risk of papillary thyroid carcinoma (PTC). MATERIALS & METHODS:  IL-27 rs153109 and rs17855750 were analyzed in 496 PTC patients and 629 controls, using a polymerase chain reaction-restriction fragment length polymorphism method. RESULTS: The rs153109 AG and AG/GG genotypes were significantly associated with increased risks for PTC...
February 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/27885839/the-association-of-plasma-mir-155-and-vcam-1-levels-with-coronary-collateral-circulation
#17
Junnan Wang, Youyou Yan, Dandan Song, Lulu Liu, Bin Liu
AIM: Inflammation plays an important role in development of coronary collateral circulation (CCC). The aim of this study is to determine whether the inflammation-related miRNA miR-155 and the inflammation marker VCAM-1 could be a biomarker for CCC. PATIENTS & METHODS: We measured levels of plasma VCAM-1 and miR-155 in patients with CCC according to Rentrop grade by ELISA or real-time polymerase chain reaction, respectively (n = 112). RESULTS: Plasma miR-155 was negatively correlated with VCAM-1 in the poor CCC group and with Rentrop grade in all patients with CCC...
February 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/27967208/welcome-to-the-11th-volume-of-biomarkers-in-medicine
#18
Hannah Wilson
No abstract text is available yet for this article.
January 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/27936870/emerging-biomarkers-for-pd-1-pathway-cancer-therapy
#19
Joline Sj Lim, Raghav Sundar, Maxime Chénard-Poirier, Juanita Lopez, Timothy A Yap
The field of immuno-oncology has witnessed unprecedented success in recent years, with several PD=1 and PD-L1 inhibitors obtaining US FDA registration and breakthrough drug therapy designation in multiple tumor types. Despite its clear efficacy in certain cancers, treatment with these agents carries a risk of immune-related toxicities and substantial financial burden. It is, therefore, critical to identify patients likely to benefit from such immunotherapies and develop strategies to differentiate responders from nonresponders early during treatment...
January 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/27917655/bone-loss-platelet-to-lymphocyte-ratio
#20
Sezen Bozkurt Koseoglu
AIM: The aim of the study is to assess the possible relation of platelet-to-lymphocyte ratio (PLR), neutrophil-to-platelet ratio and low-density lipoprotein cholesterol levels with low bone mineral density (BMD) in postmenopausal women. METHODOLOGY: In total, 211 postmenopausal women were divided into two groups according to their T-score results. The control group consisted of 32 and BMD group consisted of 179 patients. Electronic records of the patients were analyzed retrospectively...
January 2017: Biomarkers in Medicine
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