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Biomarkers in Medicine

Kelly Hares, Alastair Wilkins
No abstract text is available yet for this article.
August 3, 2017: Biomarkers in Medicine
Selami Soylemez
Letter in regards to: Akboga MK, Balci KG, Maden O et al. Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease. Biomark. Med. 10(4), 375-383 (2016).
August 3, 2017: Biomarkers in Medicine
Mehmet Kadri Akboga, Samet Yilmaz
Letter in regards to: Akboga MK, Balci KG, Maden O et al. Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease. Biomark. Med. 10(4), 375-383 (2016). In response to: Soylemez S.Oxidative stress and SYNTAX score in patients with stable coronary artery disease. Biomark. Med. 11(8), doi:10.2217/bmm-2016-0326 (2017) (Epub ahead of print).
August 3, 2017: Biomarkers in Medicine
Richard E Frye, John C Slattery, Edward V Quadros
Autism spectrum disorder (ASD) has been linked to abnormalities in folate metabolism. Polymorphisms in folate genes may act in complex polygenic ways to increase the risk of developing ASD. Autoantibodies that block folate transport into the brain have been associated with ASD and children with ASD and these autoantibodies respond to high doses of a reduced form of folate known as folinic acid (leucovorin calcium). Some of the same abnormalities are also found in mothers of children with ASD and supplementing folate during preconception and gestational periods reduces the risk to the offspring from developing ASD...
August 3, 2017: Biomarkers in Medicine
Nan Jiang, Cheng-He Qin, Yi-Long Hou, Zi-Long Yao, Bin Yu
AIM: This study aimed to investigate the values of preoperative serum levels of white blood cell, erythrocyte sedimentation rate (ESR), C-reactive protein, procalcitonin, IL-6, TNF-α and serum amyloid A for diagnosis of chronic osteomyelitis (COM) in Chinese patients. METHODS: All 586 eligible patients were included for analysis. RESULTS: Outcomes revealed that positive ratios of TNF-α, ESR and IL-6 lied in top three. Taken predicted probability and detection cost into consideration, combination of ESR, IL-6 and TNF-α might be the optimal model due to its high predicted probability for COM (91...
August 3, 2017: Biomarkers in Medicine
Jinrong Zeng, Haijing Wu, Ming Zhao, Qianjin Lu
Systemic lupus erythematosus (SLE) is a complex and highly heterogeneous disease. By now, no novel drug has been approved by the US FDA in the past 50 years, except Belimumab, a monoclonal antibody to inhibit B-cell activating factor. The stagnating drug development of lupus may be due to our limited understanding of disease etiopathogenesis and the extreme heterogeneity of patient population. Thus, the individualized treatment for SLE becomes necessary. Recently, biomarkers have shown potential in individualized treatment...
August 3, 2017: Biomarkers in Medicine
Vahit Demir, Samet Yilmaz, Mehmet Kadri Akboga
AIM: We aimed to evaluate the relationships between monocyte-to-high-density lipoprotein ratio (MHR) and lymphocyte-to-monocyte ratio (LMR) and rheumatic mitral valve stenosis (RMVS). METHODOLOGY: A total of 368 patients with mitral stenosis and 80 healthy participants were included. Patients were categorized into two groups in respect to the severity of RMVS as mild-moderate group (mitral valve area ≥1.0 cm(2)) and severe group (mitral valve area <1.0 cm(2))...
August 3, 2017: Biomarkers in Medicine
Marwa Matboli, Ayman E Shafei, Hanan H Shehata, Nesreen Nabil, Nourhan Hossam, Ahmed Em Azazy, Ahmed Hf El-Tawdi, Omar Abdel-Rahman
AIM: This study integrates autophagy transcripts miRNAs expression based on bioinformatic analysis followed by clinical validation. METHODOLOGY: Cellular jun proto-oncogene mRNA, LAMP2 mRNA, miR-16 and miR-146a level were investigated in the serum and tissue of patients with hepatocellular carcinoma (HCC), chronic hepatitis C and healthy volunteers by quantitative real-time PCR. The prognostic power of this serum RNA panel was explored. RESULTS: The expression of serum cellular jun proto-oncogene mRNA, LAMP2 mRNA, miR-16 and miR-146a were positive in 85...
August 3, 2017: Biomarkers in Medicine
Anna Synakiewicz, Malgorzata Sawicka-Zukowska, Natalia Adrianowska, Grazyna Galezowska, Joanna Ratajczyk, Anna Owczarzak, Lucyna Konieczna, Teresa Stachowicz-Stencel
AIM: Childhood cancer remains one of the main cause of death in the pediatric population. Amino acids (AAs) level alterations in plasma are considered to play a role in carcinogenesis and further course of the disease. METHODS: Seventy-seven children with cancer, including 47 with hematological and 30 with solid tumors were enrolled in this study and compared with healthy children. Twenty-two plasma-free AAs were determined by HPLC with fluorometric detection. RESULTS: The results revealed significant decrease in glutamine levels for oncological patients and significant increase in aspartic acid, glutamic acid, asparagine, serine, citrulline, alanine, GABA, tryptophan, methionine, valine, phenylalanine and isoleucine levels in cancer children versus control...
August 3, 2017: Biomarkers in Medicine
George Kafatos, Daniela Niepel, Kimberley Lowe, Sophie Jenkins-Anderson, Hal Westhead, Tamer Garawin, Zuzana Traugottová, Antonios Bilalis, Edit Molnar, Jozsef Timar, Erika Toth, Nikolaos Gouvas, George Papaxoinis, Samuel Murray, Nadia Mokhtar, Hana Vosmikova, Pavel Fabian, Alena Skalova, Piotr Wójcik, Andrzej Tysarowski, Mario Barugel, J Han van Krieken, Jörg Trojan
AIM: A confirmed wild-type RAS tumor status is commonly required for prescribing anti-EGFR treatment for metastatic colorectal cancer. This noninterventional, observational research project estimated RAS mutation prevalence from real-world sources. MATERIALS & METHODS: Aggregate RAS mutation data were collected from 12 sources in three regions. Each source was analyzed separately; pooled prevalence estimates were then derived from meta-analyses. RESULTS: The pooled RAS mutation prevalence from 4431 tumor samples tested for RAS mutation status was estimated to be 43...
July 27, 2017: Biomarkers in Medicine
Youyou Yan, Xinjing Song, Zhibo Li, Jinpu Zhang, Jiajun Ren, Junduo Wu, Yali Li, Yinuo Guan, Junnan Wang
AIM: Granzyme B could induce apoptosis of target cell in acute myocardial infarction (AMI) and was identified as the target of miR-874-3p by searching the miRNA database. We aim to determine the levels of granzyme B and miR-874-3p as well as assay their correlations or predict powers in AMI. PATIENTS & METHODS: We measured levels of plasma granzyme B and miR-874-3p in 80 AMI patients or 40 healthy controls and assayed their correlations or predicted powers for AMI...
July 12, 2017: Biomarkers in Medicine
Ju-Hua Liu, Yan Chen, Zhe Zhen, Lai-Ming Ho, Anita Tsang, Michele Yuen, Karen Lam, Hung-Fat Tse, Kai-Hang Yiu
AIM: The study evaluated the relationship of extracellular matrix and renin angiotensin system with myocardial dysfunction in Type 2 diabetes mellitus. METHODS: All patients underwent resting and exercise echocardiography, including conventional parameters, E/E' ratio, global longitudinal strain and diastolic function reserve index. Plasma matrix metalloproteinase-1, TIMP-1, amino-terminal propeptide of type I and type III procollagen and renin angiotensin system activity were measured...
July 7, 2017: Biomarkers in Medicine
Lasse H Hansen, Stine Darkner, Jesper H Svendsen, Kristoffer Henningsen, Steen Pehrson, Xu Chen, Sergey Y Vakhrushev, Katrine T Schjoldager, Jens P Goetze
AIM: To investigate whether chromogranin A (CgA) is secreted from the heart into circulation. MATERIALS & METHODS: Porcine cardiac tissue was analyzed for the presence of CgA-derived glycopeptides using a global O-glycoproteomic strategy. Blood was sampled from the femoral vein, right atrium, coronary sinus and the left atrium from patients with predominantly atrial disease. The local concentration of proatrial natriuretic peptide and CgA was measured with immunoassays...
July 7, 2017: Biomarkers in Medicine
Demir Vahit, Kadri Akboga Mehmet, Yilmaz Samet, Ede Hüseyin
AIM: We aimed to investigate the relationships between metabolic syndrome (MS) and monocyte to high density lipoprotein cholesterol ratio (MHR) and lymphocyte-to-monocyte ratio (LMR). METHODS: 762 patients (n = 371 MS present and n = 391 MS absent) were enrolled. RESULTS: MHR was significantly higher [13.9 (10.5-18.1) vs 11.1 (8.0-14.8); p < 0.001], whereas LMR was significantly lower [4.5 (3.6-5.7) vs 3.6 (2.9-4.8); p < 0.001] in patients with MS...
July 7, 2017: Biomarkers in Medicine
Harun Kundi, Murat Gok, Emrullah Kiziltunc, Mustafa Cetin, Ender Ornek
AIM: The aim of the present study is to evaluate the relationship between coronary collateral circulation (CCC) grade and serum IGF-1 levels in patients diagnosed with stable coronary artery disease. METHODS: Totally, 190 consecutive patients with stable coronary artery disease who underwent coronary angiography were included in this study. RESULTS: The patients with good CCC had significantly higher IGF-1 levels compared with the poor ones...
July 7, 2017: Biomarkers in Medicine
Hideaki Shiraishi, Yutaka Fujiwara, Takanori Kakuya, Koji Tsuta, Noriko Motoi, Nami Miura, Yukio Watabe, Shun-Ichi Watanabe, Rintaro Noro, Kengo Nagashima, Wilber Huang, Tesshi Yamada, Hisao Asamura, Yuichiro Ohe, Kazufumi Honda
AIM: Although several clinical trials demonstrated the benefits of platinum-combination adjuvant chemotherapy for stage II-IIIA lung adenocarcinoma, predictive biomarkers for the efficacy of such therapy have not yet been identified. We evaluated protein overexpression of actinin-4 as a predictive biomarker of the efficacy of adjuvant chemotherapy in resected lung adenocarcinoma. MATERIALS & METHODS: We measured actinin-4 protein levels in patients with completely resected stage II-IIIA lung adenocarcinoma using immunohistochemistry and then retrospectively compared survival between adjuvant chemotherapy and observation groups...
June 29, 2017: Biomarkers in Medicine
Marko D Banovic
No abstract text is available yet for this article.
June 23, 2017: Biomarkers in Medicine
Daniel B McArtor, Bochao D Lin, Jouke-Jan Hottenga, Dorret I Boomsma, Gonneke Willemsen, Gitta H Lubke
AIM: To assess the extent to which a multivariate approach to modeling interrelated hematological indices provides more informative results than the traditional approach of modeling each index separately. MATERIALS & METHODS: The effects of demographics and lifestyle on ten hematological indices collected from a Dutch population-based sample (n = 3278) were studied, jointly using multivariate distance matrix regression and separately using linear regression. RESULTS: The multivariate approach highlighted the main effects of all predictors and several interactions; the traditional approach highlighted only main effects...
June 23, 2017: Biomarkers in Medicine
Yuan Liu, Tao Zhang, Changcan Li, Ling Ye, Haitao Gu, Lin Zhong, Hongcheng Sun, Yahuang Sun, Zhihai Peng, Junwei Fan
AIM: The effect of SLC28A3 on tacrolimus disposition and new-onset hypertension (NOHP) after liver transplantation (LT) remains unclear. Methodology & results: A total of 169 patients in two cohorts from the China Liver Transplant Registry database were included. Rs7853758 in recipients'SLC28A3 could predict tacrolimus pharmacokinetics in two sets. The model of donors' CYP3A5 rs776746 and recipients' CYP3A4 rs2242480 could predict tacrolimus metabolism at week 1 and the model of donors' CYP3A5 rs776746, recipients' CYP3A4 rs2242480, recipients' SLC28A3 rs7853758 and hemoglobin could predict tacrolimus disposition at weeks 2, 3 and 4...
June 16, 2017: Biomarkers in Medicine
Lele Song, Yuemin Li
No abstract text is available yet for this article.
June 15, 2017: Biomarkers in Medicine
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