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IEEE Transactions on Biomedical Circuits and Systems

Angel Dieguez, Joan Canals, Nil Franch, Joel Dieguez, Oscar Alonso, Anna Vila
Time-resolved fluorescence measurement is extraordinarily powerful in the analysis of substances due to its effectiveness in eliminating measurement artifacts. Some fluorescence measurements are still conducted on CMOS chips with the decay times determined after reading the data off the chip and fitting the fluorescence decay histogram. We present a novel approach in which an analog CMOS chip divides the fluorescence decay time into slices and classifies the photons according to their arrival times at a CMOS SPAD sensor...
January 14, 2019: IEEE Transactions on Biomedical Circuits and Systems
Xiao-Hu Zhou, Gui-Bin Bian, Xiao-Liang Xie, Zeng-Guang Hou, Xinkai Qu, Shaofeng Guan
Many robotic platforms can indeed reduce radiation exposure to clinicians during percutaneous coronary intervention (PCI), however, interventionalists' natural manipulations are rarely involved in robot-assisted PCI. This requires more attention to analyze interventionalists' natural behaviors during conventional PCI. In this study, four types of natural behavior (i.e., muscle activity, hand motion, proximal force and finger motion) were synchronously acquired from ten subjects while performing six typical types of guidewire manipulation...
January 11, 2019: IEEE Transactions on Biomedical Circuits and Systems
Chenyu Wang, Yajie Qin, Han Jin, Ikhwan Kim, Jose David Granados Vergara, Chenjie Dong, Yizhou Jiang, Qifan Zhou, Junshang Li, Zishang He, Zhuo Zou, Lirong Zheng, Xiaomei Wu, Yuanyuan Wang
Nowadays, cardiovascular disease is still one of the primary diseases that limit humans' lifespan. To address this challenge, this work reports an Internet of Medical Things (IoMT)-based cardiovascular healthcare system with cross-layer optimization from sensing patch to cloud platform. A wearable ECG patch with a customized System-on-Chip (SoC) has been designed, featuring miniaturized footprint, low power consumption, and embedded signal processing capability. Meanwhile the patch holds effective connectivity to mobile devices and cloud platform for link optimization of the whole system...
January 11, 2019: IEEE Transactions on Biomedical Circuits and Systems
Denys Nikolayev, Maxim Zhadobov, Ronan Sauleau
BACKGROUND AND OBJECTIVE: In-body biotelemetry devices enable wireless monitoring of a wide range of physiological parameters. These devices rely on antennas to interface with external receivers, yet existing systems suffer from impedance detuning caused by the substantial differences in electromagnetic properties among various tissues. In this paper, we propose an immune-to-detuning in-body biotelemetry platform featuring a novel tissue-independent antenna design. METHODS: Our approach uses a novel slot-patch conformal antenna integrated into a flexible polyimide PCB containing the device circuitry and encapsulated within a 17...
January 11, 2019: IEEE Transactions on Biomedical Circuits and Systems
Dwaipayan Biswas, Luke Everson, Muqing Liu, Madhuri Panwar, Bram Verhoef, Shrishail Patrika, Chris H Kim, Amit Acharyya, Chris Van Hoof, Mario Konijnenburg, Nick Van Helleputte
Advancements in wireless sensor network technologies have enabled the proliferation of miniaturized body-worn sensors, capable of long-term pervasive biomedical signal monitoring. Remote cardiovascular monitoring has been one of the beneficiaries of this development, resulting in non-invasive, photoplethysmography (PPG) sensors being used in ambulatory settings. Wrist-worn PPG, although a popular alternative to electrocardiogram (ECG), suffers from motion artifacts inherent in daily life. Hence, in this paper, we present a novel deep learning framework (CorNET) to efficiently estimate heart rate (HR) information and perform biometric identification (BId) using only wrist-worn, single-channel PPG signal collected in ambulant environment...
January 10, 2019: IEEE Transactions on Biomedical Circuits and Systems
Byunghun Lee, Yaoyao Jia, Abdollah Mirbozorgi, Mark Connolly, Xingyuan Tong, Zhaoping Zeng, Babak Mahmoudi, Maysam Ghovanloo
An inductively-powered wireless integrated neural recording and stimulation (WINeRS-8) system-on-a-chip (SoC) that is compatible with the EnerCage-HC2 for wireless/battery- less operation has been presented for neuroscience experiments on freely behaving animals. WINeRS-8 includes a 32-ch recording analog front-end (AFE), a 4-ch current-controlled stimulator, and a 434 MHz on-off keying (OOK) data link to an external software- defined radio (SDR) wideband receiver (Rx). The headstage also has of a Bluetooth Low Energy (BLE) link for controlling the SoC...
January 7, 2019: IEEE Transactions on Biomedical Circuits and Systems
Henry Thomas Lancashire, Dai Jiang, Andreas Demosthenous, Nick Donaldson
This paper presents an active microchannel neural interface (MNI) using seven stacked application specific integrated circuits (ASIC). The approach provides a solution to the present problem of interconnect density in 3-dimensional MNIs. The 4 mm2 ASIC is implemented in 0.35 μm high-voltage CMOS technology. Each ASIC is the base for seven microchannels each with three electrodes in a pseudo-tripolar arrangement. Multiplexing allows stimulating or recording from any one of 49 channels, across 7 ASICs. Connections to the ASICs are made with a 5-line parallel bus...
January 7, 2019: IEEE Transactions on Biomedical Circuits and Systems
Roshan Timilsina, Chunqi Qian
This article demonstrates the enlarged effective range for MRI sensitivity enhancement with a deformable catheter MRI coils integrated with a wirelessly powered amplifier. The expandable balloon Wireless Amplified Nuclear magnetic resonance Detector (WAND) was constructed on a copper-clad polyimide film to resonate at the first and second harmonics of the proton Larmor frequency at 7 Tesla. The WAND was then mounted on a balloon catheter system for easy delivery inside confined orifice. Upon reaching the region of interest, it was unfolded out of the sheath tube to increase its effective size...
January 4, 2019: IEEE Transactions on Biomedical Circuits and Systems
Fang Tang, Zhou Shu, Mingdong Li, Yi Hu, Xichuan Zhou, Shengdong Hu, Zhi Lin, Ping Gan, Tiancong Huang, Amine Bermak
This paper presents a monolithic low power and fast tracking light-to-frequency converter for blood SpO2 sensing. Normally, the tracking speed and the power consumption are two contradictory characteristics. However different gain-bandwidth specifications for various ambient light intensities allow the dynamically optimization of the power consumption according to the light intensity. In this paper, the amplifier power consumption is adaptively scaled by the generated light-intensity-positively-correlated control voltage...
December 27, 2018: IEEE Transactions on Biomedical Circuits and Systems
Wen Li, Yida Duan, Jan Rabaey
This paper presents an energy efficient wireless transmitter (TX) for neural implants. It utilizes inductive coupling with de-Q'ed TX inductor to achieve 200Mbps throughput. An ultra-low power injection locked phase lock loop (PLL) with background frequency calibration generates a clean 200MHz TX clock from a 10MHz reference. The TX chip is fabricated in TSMC 65nm CMOS process, and the 10×10mm 2 coupled inductors are implemented on 2-layer printed circuit boards (PCB). A custom receiver (RX) is fabricated in the same CMOS process to facilitate measurements...
December 25, 2018: IEEE Transactions on Biomedical Circuits and Systems
Mohammad Abdeljaleel Amayreh, Gerhard Baaken, Jan C Behrends, Yiannos Manoli
This paper presents a fully integrated low noise current-to-digital converter based on current-mode continuous-time delta-sigma modulators (CT DSMs). The circuit was realized in standard 0.35 μm CMOS process and achieves a noise floor as low as 200 fArms within a bandwidth of 10 kHz. Thanks to the continuous-time architecture, the oversampling together with the implicit anti-aliasing behavior of the current-mode CT DSM prevents the back folding of any out-of-band signals and noises. Running at a sampling frequency of 1...
December 24, 2018: IEEE Transactions on Biomedical Circuits and Systems
Dejan Rozgic, Vahagn Hokhikyan, Wenlong Jiang, Ippei Akita, Sina Basir-Kazeruni, Hariprasad Chandrakumar, Dejan Markovic
Neuromodulation (NM) is the alteration of nervous tissue function through targeted delivery of a stimulus, such as electrical stimulation, into the affected neurological sites in the body. We present a "holy- grail" bi-directional NM interface that features 100mVpp linear input range and ability to sense data concurrent with stimulation (without blanking). The system includes a flexible 8-driver-to-64-contact custom waveform stimulator able to deliver up to 5.1mA per driver and a 64-contact sensing unit with online blind artifact rejection unit...
December 21, 2018: IEEE Transactions on Biomedical Circuits and Systems
Ali Pourahmad, Rasoul Dehghani
This paper presents an innovative current modulator active electrode (CMAE) with only two outgoing wires that reduces cost and complexity of wearable bioamplifiers based on dry electrodes. The CMAE can be considered as an operational transconductance amplifier (OTA) which modulates the supply current by input voltage signal through its two supply rails. The CMAE prototype is implemented with only two discrete op-amps for ECG and EEG recording with current consumption of 60 μA and 100 μA, respectively. The CMAE's built-in preamplifier has utilized a DC feedback loop (DFL), instead of the conventional DC servo loop (DSL), which suppresses electrode offset (EO) in almost rail-to-rail...
December 20, 2018: IEEE Transactions on Biomedical Circuits and Systems
Carlos E Christoffersen, Thinh Ngo, Ruiqi Song, Yushi Zhou, Samuel Pichardo, Laura Curiel
Recently a method was proposed to determine the parameters for each Class DE driver in high-intensity focused ultrasound (HIFU) arrays for efficient operation and to compensate for variations in the impedance of each array element. This work extends that method to consider the effect of switch resistance and to provide limited control on the power delivered to the transducers with a constant supply voltage while keeping a good efficiency. The method is experimentally validated using an integrated driver developed by the authors...
December 20, 2018: IEEE Transactions on Biomedical Circuits and Systems
Ying Wei, Tong Ma, Bing Kun Ho, Yong Lian
A computationally efficient, low power (107.6μW@1.1V), small core area (2.82 mm 2 0.35μm), 16-band nonuniformly spaced digital filter bank with stop-band attenuation of more than 60dB is designed and implemented for hearing aid applications using 0.35μm CMOS process. The low computational complexity of the filter bank is achieved using Frequency Response Masking (FRM) technique with multiple band-edge shaping filters. The proposed filter bank yields significant improvements in both power consumption and group delay...
December 20, 2018: IEEE Transactions on Biomedical Circuits and Systems
Zhanwei Zhong, Zipeng Li, Krishnendu Chakrabarty, Tsung-Yi Ho, Chen-Yi Lee
Digital microfluidic biochips (DMFBs) are being increasingly used for DNA sequencing, point-of-care clinical diagnostics and immunoassays. DMFBs based on a micro-electrodedot-array (MEDA) architecture have recently been proposed, and fundamental droplet manipulations, e.g., droplet mixing and splitting, have also been experimentally demonstrated on MEDA biochips. There can be thousands of microelectrodes on a single MEDA biochip, and the fine-grained control of nanoliter volumes of biochemical samples and reagents is also enabled by this technology...
December 14, 2018: IEEE Transactions on Biomedical Circuits and Systems
Lukas Bereuter, Timon Kuenzle, Thomas Niederhauser, Martin Kucera, Dominik Obrist, Tobias Reichlin, Hildegard Tanner, Andreas Haeberlin
OBJECTIVE: A new generation of leadless cardiac pacemakers effectively overcomes the main limitations of conventional devices, but only offer single-chamber pacing, although dual-chamber or multisite pacing is highly desirable for most patients. The combination of several leadless pacemakers could facilitate a leadless multisite pacemaker but requires an energy-efficient wireless communication for device synchronization. This work investigates the characteristics of conductive intracardiac communication between leadless pacemakers to provide a basis for future designs of leadless multisite pacemaker systems...
December 10, 2018: IEEE Transactions on Biomedical Circuits and Systems
Lorenzo Pasotti, Massimo Bellato, Nicolo Politi, Michela Casanova, Susanna Zucca, Maria Gabriella Cusella De Angelis, Paolo Magni
Feedback control is ubiquitous in biological systems. It can also play a crucial role in the design of synthetic circuits implementing novel functions in living systems, to achieve self-regulation of gene expression, noise reduction, rise time decrease, or adaptive pathway control. Despite in vitro, in vivo and ex vivo implementations have been successfully reported, the design of biological close-loop systems with quantitatively predictable behavior is still a major challenge. In this work, we tested a model-based bottom-up design of a synthetic close-loop controller in engineered Escherichia coli, aimed to automatically regulate the concentration of an extracellular molecule, N-(3-oxohexanoyl)-L-homoserine lactone (HSL), by re-wiring the elements of heterologous quorum sensing/quenching networks...
November 26, 2018: IEEE Transactions on Biomedical Circuits and Systems
Jiawei Xu, Mario Konijnenburg, Shuang Song, Hyunsoo Ha, Roland van Wegberg, Chris Van Hoof, Massimo Mazzillo, Giorgio Fallica, Walter De Raedt, Nick Van Helleputte
This paper presents a sub-mW ASIC for multimodal brain monitoring. The ASIC is co-integrated with electrode(s) and optodes (i.e. optical source and detector) as an active sensor to measure electroencephalography (EEG), bio-impedance (BioZ), and near-infrared spectroscopy (NIRS) on scalp. The target is to build a wearable EEG-NIRS headset for low-cost functional brain imaging. The proposed NIRS readout utilizing the near-infrared light can be used to measure the pulse oximetry and blood oxygen saturation (SpO2)...
November 26, 2018: IEEE Transactions on Biomedical Circuits and Systems
Shuenn-Yuh Lee, Cheng-Pin Wang, Yuan-Sun Chu
This paper presents a systematic method for decreasing the amount of transconductors used by an operational transconductance amplifier-capacitor (OTA-C) filter to decrease the power consumption and the active area. An OTA with a local-feedback linearized technique and a transconductance booster is proposed based on the presented method. The proposed OTA combines current division with source degeneration to enhance linearity and implement low transconductance. This topology enables the proposed OTA to drive multiple integration capacitors without an additional output stage...
November 20, 2018: IEEE Transactions on Biomedical Circuits and Systems
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