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Journal of the American Society of Hypertension: JASH

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https://www.readbyqxmd.com/read/29287945/mechanisms-of-pulse-pressure-amplification-dipping-pattern-during-sleep-time-the-safar-study
#1
Antonios A Argyris, Efthimia Nasothimiou, Evaggelia Aissopou, Theodoros G Papaioannou, Yi Zhang, Jacques Blacher, Michel E Safar, Petros P Sfikakis, Athanase D Protogerou
The difference in pulse pressure (PP) between peripheral arteries and the aorta, called pulse pressure amplification (PPamp), is a well-described physiological phenomenon independently associated with cardiovascular events. Recent studies suggest that it exhibits circadian variability. Our aim was to detect the factors associated with the circadian variability of PPamp. In 497 consecutive subjects (aged 54 years, 56.7% male, 79.7% hypertensives), we assessed the circadian pattern of peripheral and central arterial hemodynamics by 24-hour evaluation of brachial and aortic blood pressure (BP), augmentation index (AI), and pulse wave velocity (PWV) using a validated oscillometric device (Mobil-O-Graph)...
December 14, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29275922/effects-of-orlistat-on-blood-pressure-a-systematic-review-and-meta-analysis-of-27-randomized-controlled-clinical-trials
#2
Amirhossein Sahebkar, Luis E Simental-Mendía, Petri T Kovanen, Claudio Pedone, Mario Simental-Mendía, Arrigo F G Cicero
Obesity and high blood pressure (BP) are strongly related and weight loss is mightily associated with a significant BP decrease. The aim of the present meta-analysis was to evaluate and quantify the BP decrease associated with orlistat use in randomized controlled trials. The search included PubMed-Medline, Scopus, Web of Science and Google Scholar databases by up to June 05, 2017, to identify randomized controlled trials investigating the impact of orlistat on blood pressure. Quantitative data synthesis was performed using a random-effects model, with weighed mean difference and 95% confidence interval as summary statistics...
December 14, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29275921/patients-with-hypertensive-responses-to-exercise-or-dobutamine-stress-testing-differ-in-resting-hypertensive-phenotype
#3
Andrew Kieu, Armaan Shaikh, Mark Kaeppler, Robert J Miles, Michael E Widlansky
Little is known of the importance of echocardiographic measures of resting systemic vascular resistance (SVR), cardiac output, and diastolic function in the development of a hypertensive response during dobutamine stress echocardiography. We performed a retrospective review of 325 subjects who underwent stress echocardiography and a resting echocardiogram on the same day. Logistical regressions were performed to determine associations between hypertensive response to each type of stress test and clinical and hemodynamic measurements obtained by transthoracic echocardiography...
December 14, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29305116/urine-albumin-is-a-superior-predictor-of-preeclampsia-compared-to-urine-plasminogen-in-type-i-diabetes-patients
#4
Lise Hald Nielsen, Boye L Jensen, Jens Fuglsang, Lise Lotte Torvin Andersen, Dorte Møller Jensen, Jan Stener Jørgensen, Gitte Kitlen, Per Ovesen
Pregnant women with type I diabetes mellitus (T1DM) are at increased risk of developing preeclampsia (PE). Plasminogen is aberrantly filtrated from plasma into tubular fluid in PE patients and activated to plasmin. Plasmin activates the epithelial sodium channel in the collecting ducts potentially causing impaired sodium excretion, suppression of the renin-angiotensin-aldosterone system, and hypertension in PE. The objective of the study was to test whether urinary total plasmin(ogen)/creatinine ratio and plasma concentration of aldosterone were better predictors of PE in pregnant women with T1DM compared with urine albumin and haemoglobin A1C...
December 13, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29289467/control-of-cardiovascular-disease-risk-factors-among-patients-with-type-ii-diabetes-in-a-primary-care-setting-in-beijing
#5
Hui-Juan Zuo, Wen-Hua Wang, Li-Qun Deng, Jiang-Lian Su
The aim of this study was to assess the control of blood glucose, blood pressure (BP), serum low-density lipoprotein cholesterol (LDL-c), and other cardiovascular disease risk factors among patients with type II diabetes in a primary-care setting in Beijing. We performed a cross-sectional, multi-center survey of 4056 patients with type II diabetes aged ≥40 years. In total, 22.6% were current smokers, 10.8% often drank alcohol, 29.0% were obese, and 67.4% participated in adequate levels of physical activity...
December 13, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29273276/aldosterone-as-a-mediator-of-microvascular-and-macrovascular-damage-in-a-population-of-normotensive-to-early-stage-hypertensive-individuals
#6
Eugenia Gkaliagkousi, Panagiota Anyfanti, Areti Triantafyllou, Eleni Gavriilaki, Barbara Nikolaidou, Antonios Lazaridis, Anastasios Vamvakis, Stella Douma
We investigated whether aldosterone concurrently mediates microvascular and macrovascular impairment, in a population of treatment-naïve young- to middle-aged individuals free from cardiovascular comorbidities. Newly diagnosed, never-treated essential hypertensive patients and normotensive individuals participated in the study. Pulse wave velocity (PWV) and augmentation index were estimated with applanation tonometry. Microalbuminuria was determined from 24-hour urine collections. Laboratory tests included measurement of plasma renin activity, serum aldosterone, and high-sensitivity C-reactive protein...
December 11, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29289466/angiotensin-ii-type-2-receptor-inhibits-expression-and-function-of-insulin-receptor-in-rat-renal-proximal-tubule-cells
#7
Yang Yang, Caiyu Chen, Chunjiang Fu, Zaicheng Xu, Cong Lan, Yongchun Zeng, Zhi Chen, Pedro A Jose, Ye Zhang, Chunyu Zeng
Both renin-angiotensin systems and insulin participate in kidney-involved blood pressure regulation. Activation of angiotensin II type 2 receptor (AT2R) decreases sodium reabsorption in renal proximal tubule (RPT) cells, whereas insulin produces the opposite effect. We presume that AT2R has an inhibitory effect on insulin receptor expression in RPT cells, which may affect renal sodium transport and therefore be of physiological or pathological significance. Our present study found that activation of AT2R inhibited insulin receptor expression in a concentration and time-dependent manner in RPT cells from Wistar-Kyoto (WKY) rats...
December 6, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29275920/the-effect-of-intermittent-fasting-on-blood-pressure-variability-in-patients-with-newly-diagnosed-hypertension-or-prehypertension
#8
Yunus Erdem, Gülsüm Özkan, Şükrü Ulusoy, Mustafa Arıcı, Ülver Derici, Şule Şengül, Şükrü Sindel, Şehsuvar Ertürk
Intermittent fasting is a phenomenon which can be observed in most humans. The effect of intermittent fasting on blood pressure variability (BPV) has not previously been investigated. The purpose of this study was to assess the effect of fasting on blood pressure (BP) (with office, home, central, and ambulatory blood pressure monitoring [ABPM]) and on BPV. Sixty individuals were included in the study. Office, home, ABPM, and central BP measurements were performed before and during intermittent fasting. Standard deviation and coefficient variation were used for office and home BPV measurement, while the smoothness index was used to calculate ABPM variability...
December 6, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29246686/relation-of-urinary-endothelin-1-to-stress-induced-pressure-natriuresis-in-healthy-adolescents
#9
Shreya Mathur, Jennifer S Pollock, Sunil Mathur, Gregory A Harshfield, David M Pollock
We hypothesize that delayed natriuresis during mental stress increases the risk of hypertension and other diseases. Our preclinical studies demonstrate an important role for renal endothelin-1 (ET-1) in regulating sodium excretion. Thus, we predict ET-1 may be linked to the delayed stress response in at-risk individuals. We hypothesize that reduced renal ET-1 accounts for derangements in sodium handling under stress, a link never explored in a large human cohort. We determined urinary ET-1 excretion in three observational studies of changes in sodium excretion during mental stress, in which 776 healthy youth (15-19 years) enrolled in a 5-hour protocol (2 hours of rest before and after 1 hour of mental stress)...
November 24, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29208471/high-dietary-intake-of-aromatic-amino-acids-increases-risk-of-hypertension
#10
Farshad Teymoori, Golaleh Asghari, Parvin Mirmiran, Fereidoun Azizi
Recent studies investigated the relation between amino acids and blood pressure. Our aim was to examine the association between intake of aromatic amino acids (AAAs) and risk of hypertension. A total of 4288 individuals, aged 20-70 years, participants of the Tehran Lipid and Glucose Study, who were free of hypertension at baseline (2008-2011), were followed for 3 years (2011-2014). Average intakes of AAAs including phenylalanine, tyrosine, and tryptophan were collected using a valid and reliable food frequency questionnaire at baseline...
November 24, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29199092/occupational-noise-exposure-and-hypertension-the-dongfeng-tongji-cohort-study
#11
Dongming Wang, Min Zhou, Wenzhen Li, Weijia Kong, Zhichao Wang, Yanjun Guo, Xiaomin Zhang, Meian He, Huan Guo, Weihong Chen
The association between occupational noise exposure and hypertension is unclear. We aimed to explore the association in a Chinese population and to summarize our findings with previous published articles. The cross-sectional study included 22,450 participants from Dongfeng-Tongji Cohort Study. In a subsample of 10,636 subjects, we assessed the association between hearing loss and hypertension. For the meta-analysis, we searched PubMed and EMBASE until April 2017, and the pooled odds ratio (OR) was combined using a random effect model...
November 13, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29146156/latest-guidelines-for-hypertension-adopt-and-adapt
#12
EDITORIAL
C Venkata S Ram
No abstract text is available yet for this article.
November 13, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29195913/association-of-office-and-ambulatory-blood-pressure-with-blood-lead-in-workers-before-occupational-exposure
#13
Wen-Yi Yang, Ljupcho Efremov, Blerim Mujaj, Zhen-Yu Zhang, Fang-Fei Wei, Qi-Fang Huang, Lutgarde Thijs, Thomas Vanassche, Tim S Nawrot, Jan A Staessen
In view of decreasing lead exposure and guidelines endorsing ambulatory above office blood pressure (BP) measurement, we reassessed association of BP with blood lead (BL) in 236 newly employed men (mean age, 28.6 years) without previous lead exposure not treated for hypertension. Office BP was the mean of five auscultatory readings at one visit. Twenty-four-hour BP was recorded at 15- and 30-minute intervals during wakefulness and sleep. BL was determined by inductively coupled plasma mass spectrometry. Systolic/diastolic office BP averaged 120...
November 9, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29146157/angiotensin-converting-enzyme-2-activation-ameliorates-pulmonary-endothelial-dysfunction-in-rats-with-pulmonary-arterial-hypertension-through-mediating-phosphorylation-of-endothelial-nitric-oxide-synthase
#14
Gang Li, Han Zhang, Lei Zhao, Yaozhong Zhang, Daole Yan, Yinglong Liu
This study aims to investigate the effect of angiotensin-converting enzyme 2 (ACE2) activation on pulmonary endothelial function in the process of preventing pulmonary arterial hypertension (PAH) in rat models and to explore the underlying mechanisms. Specific pathogen free rats were randomly divided into five groups including control group, PAH group, PAH + Resorcinolnaphthalein (Res) group (ACE2 activation), PAH + Res + MLN4760 group (ACE2 inhibition), and PAH + Res + L-NAME group (endothelial nitric oxide synthase [eNOS] inhibition)...
October 28, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29306390/from-the-editor
#15
EDITORIAL
Daniel Levy
No abstract text is available yet for this article.
January 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29246379/from-the-editor
#16
EDITORIAL
Daniel Levy
No abstract text is available yet for this article.
December 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29146158/plasma-microrna-155-5p-is-increased-among-patients-with-chronic-kidney-disease-and-nocturnal-hypertension
#17
Dominika Klimczak, Marek Kuch, Tomasz Pilecki, Dorota Żochowska, Agnieszka Wirkowska, Leszek Pączek
MicroRNAs play multiple roles in the regulation of blood pressure (BP). Nevertheless, to date, no study has assessed the association between microRNA plasma expression and BP control in chronic kidney disease (CKD) patients. Given this background, we evaluated the plasma expression of miR-155-5p, a translational inhibitor of angiotensin receptor type I, in CKD patients, to determine the association between miR-155-5p level and BP control. In this single-center cross-sectional study, we analyzed the miR-155-5p concentration by quantitative reverse transcriptase polymerase chain reaction using the U6 snRNA as a reference gene and 24-hour ambulatory blood pressure monitoring in CKD patients (stage ≥2) in relation to a control group of healthy age-matched and gender-matched individuals, with normal BP proven by the ambulatory blood pressure monitoring...
December 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29128603/optimal-blood-pressure-control-after-coronary-events-the-challenge-remains
#18
Elise Sverre, Kari Peersen, Jan Erik Otterstad, Lars Gullestad, Joep Perk, Erik Gjertsen, Torbjørn Moum, Einar Husebye, Toril Dammen, John Munkhaugen
We identified sociodemographic, medical, and psychosocial factors associated with unfavorable blood pressure (BP) control in 1012 patients, hospitalized with myocardial infarction and/or a coronary revascularization procedure. This cross-sectional study collected data from hospital records, a comprehensive self-report questionnaire, clinical examination, and blood samples after 2-36 (mean 17) months follow-up. Forty-six percent had unfavorable BP control (≥140/90 [80 in diabetics] mm Hg) at follow-up. Low socioeconomic status and psychosocial factors did not predict unfavorable BP control...
December 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29128028/from-the-editor
#19
EDITORIAL
Daniel Levy
No abstract text is available yet for this article.
November 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29054402/from-the-president-american-society-of-hypertension
#20
EDITORIAL
John D Bisognano, Jan N Basile
No abstract text is available yet for this article.
November 2017: Journal of the American Society of Hypertension: JASH
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