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Journal of the American Society of Hypertension: JASH

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https://www.readbyqxmd.com/read/29776759/effect-of-vitamin-d-supplementation-on-blood-pressure-parameters-in-patients-with-vitamin-d-deficiency-a-systematic-review-and-meta-analysis
#1
REVIEW
Liqin Shu, Kun Huang
Evidence suggests that supplementation of vitamin D cannot decrease blood pressure in normal populations. However, in randomized controlled trials (RCTs) with vitamin D deficient participants (defined as baseline serum 25[OH]D levels <30 ng/mL or 50 nmol/L), this effect is inconsistent and under debate. Thus, we performed this systematic review and meta-analysis to evaluate whether vitamin D supplementation could affect blood pressure parameters in vitamin D-deficient subjects. The PubMed, Web of Science, ScienceDirect, and Cochrane library databases were searched...
May 9, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29680225/ethanol-withdrawal-increases-blood-pressure-and-vascular-oxidative-stress-a-role-for-angiotensin-type-1-receptors
#2
Natália A Gonzaga, Gabriel T do Vale, Juliana M Parente, Rodrigo Yokota, Bruno S De Martinis, Dulce E Casarini, Michele M Castro, Carlos R Tirapelli
We evaluated the possible mechanisms underlying the oxidative stress induced by ethanol withdrawal. With this purpose, we verified the role of AT1 receptors in such response. Male Wistar rats were treated with ethanol 3%-9% (vol./vol.) for 21 days. Ethanol withdrawal was induced by abrupt discontinuation of the treatment. Experiments were performed 48 hours after ethanol discontinuation. Increased plasma levels of angiotensin II were detected after ethanol withdrawal. Losartan (10 mg/kg; p.o. gavage), a selective AT1 receptor antagonist, impeded the increase in blood pressure induced by ethanol withdrawal...
April 4, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29699875/stroke-and-or-myocardial-infarction-attributable-to-modifiable-risk-factors-in-henan-china
#3
Kaiyan Dong, Qian Yang, Fujiao Duan, Shuying Liang, Nan Ma, Wei Nie, Yali Yan, Ye Zhang, Rui Peng, Shuaibing Wang, Chunhua Song, Kaijuan Wang
Estimating population attributable risks of potential modifiable risk factors for stroke and (or) myocardial infarction may be useful for planning cardiovascular disease (CVD) preventive strategies. A population of 17,292 adults aged 18 years and older from a cross-sectional survey was included in the study. The binary logistic regression was used to evaluate the association between risk factors with disease events, then population attributable fraction according to prevalence and odds ratios were calculated to identify and compare the effects at different subpopulations...
April 3, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29678422/significant-interaction-of-hypertension-and-homocysteine-on-neurological-severity-in-first-ever-ischemic-stroke-patients
#4
Ying-Li Fan, Rui Zhan, Yi-Fei Dong, Lei Huang, Xi-Xin Ji, Peng Lu, Jian Liu, Ping Li, Xiao-Shu Cheng
It is not known whether combination of hypertension and high homocysteine (HHcy) impacts on stroke-related neurological severity. Our aim was to determine whether there is an interaction of hypertension and HHcy on neurological severity in first-ever ischemic stroke patients. We analyzed neurological severity among 189 consecutive first-ever ischemic stroke patients with or without hypertension or HHcy. Hypertension (odds ratio [OR]: 8.086, 95% confidence interval [CI]: 3.596-18.181, P < .001) and total homocysteine (OR: 1...
April 3, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29678423/dose-response-relationship-between-visceral-fat-index-and-untreated-hypertension-in-chinese-rural-population-the-ruraldiab-study
#5
Zhongyan Tian, Yuqian Li, Linlin Li, Xiaotian Liu, Yuanyuan Shi, Kaili Yang, Ruihua Liu, Honglei Zhang, Xinling Qian, Lei Yin, Jingzhi Zhao, Chongjian Wang
The study aimed to explore the association of visceral fat index (VFI) with untreated hypertension in different genders and evaluate the practicability of VFI as a marker for discriminating untreated hypertension in Chinese rural population. A total of 12,536 eligible participants aged 35 years and older were derived from the RuralDiab study in China. VFI was assessed with bioelectrical impendence methods and divided into sex-specific quartiles. Logistic regression and restricted cubic spline regression were performed...
March 29, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29678424/comparison-of-three-formulas-to-estimate-24-hour-urinary-sodium-and-potassium-excretion-in-patients-hospitalized-in-a-hypertension-unit
#6
Piotr Jędrusik, Bartosz Symonides, Zbigniew Gaciong
Measurements of 24-hour urinary sodium (24hrUNa) and potassium (24hrUK) excretion are useful in hypertensives but 24-hour urine collection may be difficult or unreliable. We compared three formulas (Tanaka, Kawasaki, Pan American Health Organization [PAHO]) proposed to estimate 24hrUNa and 24hrUK based on spot urine measurements. We studied 382 patients admitted to a hypertension unit. Sodium, potassium, and creatinine levels were measured using standard laboratory methods in a morning urine sample, followed by 24-hour urinary collection...
March 28, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29703600/vascular-toxicities-with-vegf-inhibitor-therapies-focus-on-hypertension-and-arterial-thrombotic-events
#7
REVIEW
Rhian M Touyz, Sandra M S Herrmann, Joerg Herrmann
The vascular endothelial growth factor (VEGF) signaling pathway (VSP) fulfills a cardinal role in endothelial cells and its inhibition has profound cardiovascular impact. This is true not only for the normal vasculature but also for the tumor vasculature when VSP inhibitors are used as anti-angiogenic therapies. Generalized endothelial dysfunction predisposes to vasoconstriction, atherosclerosis, platelet activation, and thrombosis (arterial more than venous). All of these have been reported with VSP inhibitors and collectively give rise to vascular toxicities, the most concerning of which are arterial thromboembolic events (ATE)...
March 21, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29681522/epidemiologic-observations-guiding-clinical-application-of-a-urinary-peptidomic-marker-of-diastolic-left-ventricular-dysfunction
#8
Zhen-Yu Zhang, Esther Nkuipou-Kenfack, Wen-Yi Yang, Fang-Fei Wei, Nicholas Cauwenberghs, Lutgarde Thijs, Qi-Fang Huang, Ying-Mei Feng, Joost P Schanstra, Tatiana Kuznetsova, Jens-Uwe Voigt, Peter Verhamme, Harald Mischak, Jan A Staessen
Hypertension, obesity, and old age are major risk factors for left ventricular (LV) diastolic dysfunction (LVDD), but easily applicable screening tools for people at risk are lacking. We investigated whether HF1, a urinary biomarker consisting of 85 peptides, can predict over a 5-year time span mildly impaired diastolic LV function as assessed by echocardiography. In 645 white Flemish (50.5% women; 50.9 years [mean]), we measured HF1 by capillary electrophoresis coupled with mass spectrometry in 2005-2010. We measured early (E) and late (A) peak velocities of the transmitral blood flow and early (e') and late (a') mitral annular peak velocities and their ratios in 2009-2013...
March 21, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29628351/rationale-and-evidence-for-the-development-of-a-durable-device-based-cardiac-neuromodulation-therapy-for-hypertension
#9
Bing Yang, Yue Wang, Fengxiang Zhang, Weizhu Ju, Hongwu Chen, Yuval Mika, Ricardo Aviv, Steven J Evans, Daniel Burkhoff, Jie Wang, Minglong Chen
We assessed the feasibility of achieving acute, sustained blood pressure reductions through the use of cardiac pacing algorithms delivered via standard dual-chamber pacing based on introducing short atrio-ventricular (AV) delays (SAVD). Eighteen hypertensive subjects (57.3 ± 9.8 years old; 10 male and 8 female) with average initial systolic and diastolic blood pressures of 151.2 ± 17.6/92.2 ± 12.7 mmHg already scheduled to undergo an invasive electrophysiology procedure were included in this study. Pacing sequences were applied for ∼1-minute intervals with AV delays of 80, 40, 20 and 2 ms, while making high fidelity blood pressure measurements...
March 21, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29609980/age-and-gender-dependent-associations-of-blood-pressure-and-serum-sodium-and-potassium-renal-and-extrarenal-regulations
#10
Hongbing Sun, Michael Sun
Association analyses between blood pressure (BP) and serum sodium and potassium for 14,657 men and 16,977 women between ages 12 and 85 years show that responses of BP to serum sodium and potassium are age and gender dependent. The data were from the National Health and Nutrition Examination Survey between 2003 and 2014. Associations between serum sodium and BP are positive only for advanced age groups and for serum sodium level greater than 139-140 mmol/L in less advanced groups. These positive associations can be explained by traditional renal-centered mechanism...
March 21, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29605539/integrated-flow-mediated-vasodilation-response-predicts-cardiovascular-events-in-elderly-patients-with-cardiovascular-risk-factors-the-japan-morning-surge-home-blood-pressure-study
#11
Tomoyuki Kabutoya, Satoshi Hoshide, Kazuomi Kario
The integrated flow-mediated vasodilation (FMD) response has been associated with cardiovascular (CV) risk factors, but the association between the integrated FMD response and subsequent CV events has been unclear. We enrolled 555 patients who had at least one CV risk factor (hypertension, dyslipidemia, diabetes, or smoking). We measured the peak percentage change in diameter (ΔFMD), and integrated FMD response calculated as the area under the dilation curve over a 120-second dilation period (FMD-AUC120 )...
March 21, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29752040/mesenchymal-stem-cell-derived-microvesicles-alleviate-pulmonary-arterial-hypertension-by-regulating-renin-angiotensin-system
#12
Zhenjun Liu, Jinghu Liu, Mengyuan Xiao, Junxian Wang, Feng Yao, Weikai Zeng, Liqin Yu, Yuejie Guan, Wenyan Wei, Zijian Peng, Kunpeng Zhu, Jin Wang, Zhongyuan Yang, Jixin Zhong, Jianying Chen
In recent years, microvesicles (MVs) derived from mesenchymal stem cells (MSCs) have been proved to be able to improve the outcome of pulmonary arterial hypertension (PAH) in many respects, but the underlying mechanisms of it still remain unclear. Because the renin-angiotensin system (RAS) has been found to be closely related to PAH, the present study was designed to investigate whether the effect of MSC-derived MVs on PAH was correlated with RAS. MVs were isolated and purified from bone marrow MSCs. PAH rat models were established by a single intraperitoneal injection of 1% monocrotaline (MCT, 50 mg/Kg)...
March 15, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29606529/inverted-u-shaped-curve-relationship-between-red-blood-cell-distribution-width-and-hypertension-in-a-large-health-checkup-population-in-china
#13
Mingfei Jiang, Xiaojuan Zha, Zewei Wu, Xinying Zhu, Wenbo Li, Huan Wu, Jun Ma, Shuyi Wang, Yufeng Wen
This study was aimed at investigating the relationship between red blood cell distribution width (RDW) and hypertension in a large health check up population in China. A population of 302,527 subjects from Wuhu was enrolled in this cross-sectional health check up study between 2011 and 2016. They consisted of 126,369 women (41.78%) and 176,158 men (58.23%) with mean age of 46.9 ± 13.4 and 48.1 ± 13.7 years, respectively. The investigations included information on demographic characteristics, physical examination, and laboratory testing...
March 10, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29605538/cadmium-body-burden-hypertension-and-changes-in-blood-pressure-over-time-results-from-a-prospective-cohort-study-in-american-indians
#14
Clare Oliver-Williams, Annie Green Howard, Ana Navas-Acien, Barbara V Howard, Maria Tellez-Plaza, Nora Franceschini
American Indian communities are at greater risk of hypertension and cardiovascular disease than the general US population and are exposed to greater cadmium levels. However, cadmium's effect on blood pressure is unclear. This study assesses the association between baseline urinary cadmium and longitudinal changes in blood pressure in American Indian communities. Cadmium was measured in 3047 baseline urine samples from Strong Heart Study participants from three geographic areas. Longitudinal changes in blood pressure across three study visits (1989-1999) were modeled using linear mixed models by baseline log urinary cadmium to creatinine ratio...
March 10, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29573975/can-a-polypill-one-single-tablet-combat-different-cardiovascular-risk-factors
#15
REVIEW
Talma Rosenthal
Polypharmacy is defined as the use of two or more drugs simultaneously. Cardiovascular drugs and antihypertensives are commonly prescribed for treatment of cardiovascular disease (CVD), especially in elderly patients. Recent studies in patients with a history of CVD demonstrated that the fixed-dose combination of cardiovascular drugs in a polypill retain their individual efficacy, safety, and tolerability, thus have the potential to improve medication adherence and multiple risk factor control, thereby improving patient outcomes in secondary cardiovascular prevention...
March 2, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29550458/circulating-bone-morphogenetic-protein-9-levels-are-associated-with-hypertension-and-insulin-resistance-in-humans
#16
Hong Huang, Wei Wang, Gangyi Yang, Yu Zhang, Xiaoqiang Li, Hua Liu, Lin Zhang, Hongting Zheng, Ling Li
It has been demonstrated that bone morphogenetic protein-9 (BMP-9) may have an important role in vascular development and stability. However, the association of circulating BMP-9 with essential hypertension (HTN) has not been established in humans. The objective of this study is to observe the changes of circulating BMP-9 levels in patients with HTN and to investigate the association of circulation BMP-9 and insulin resistance (IR) in a cross-sectional study. Two hundred twenty-five individuals, including 132 patients with hypertension, and 93 healthy controls, were included in the present study...
March 1, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29548933/impact-of-masked-hypertension-on-diabetic-nephropathy-in-patients-with-type-ii-diabetes-a-kamogawa-hbp-study
#17
Emi Ushigome, Chikako Oyabu, Toru Tanaka, Goji Hasegawa, Masayoshi Ohnishi, Sei Tsunoda, Hidetaka Ushigome, Isao Yokota, Naoto Nakamura, Yohei Oda, Mai Asano, Muhei Tanaka, Masahiro Yamazaki, Michiaki Fukui
The prognostic significance of masked hypertension (MH) on the progression of diabetic nephropathy among patients with type II diabetes is not well documented. We examined the relationship between clinic systolic blood pressure (SBP) and morning home SBP measurements and progression to macroalbuminuria in patients with type II diabetes. We analyzed prospective cohort study data from 712 patients with type II diabetes. We classified the patients into the following four groups according to their clinic (130 mm Hg) and home (125 mm Hg) SBP measurements: controlled blood pressure group, white-coat hypertension group, MH group, and sustained hypertension (SH) group...
March 1, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29753406/from-the-editor
#18
EDITORIAL
Daniel Levy
No abstract text is available yet for this article.
May 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29501551/the-relationship-of-depression-with-the-level-of-blood-pressure-in-population-based-kangbuk-samsung-health-study
#19
Sung Keun Park, Ju Young Jung, Jae-Hong Ryoo, Chang-Mo Oh, Jae-Hon Lee, Zihang Pan, Rodrigo B Mansur, Margarita Shekotikhina, Roger S McIntyre, Joong-Myung Choi
There has been increasing evidence about psychosomatic relationship between mood disorder and blood pressure (BP). However, the degree to which BP categories are associated with depression has been less well described. Thus, this study was to investigate the association of depression with BP categories. A total of 90,643 men and 68,933 women were enrolled in this study. They were stratified into four groups (normal, prehypertension, newly diagnosed hypertension, and recognized hypertension) according to the BP levels and the history of hypertension...
May 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29731122/from-the-editor
#20
EDITORIAL
Daniel Levy
No abstract text is available yet for this article.
April 2018: Journal of the American Society of Hypertension: JASH
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