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Clinical Schizophrenia & related Psychoses

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https://www.readbyqxmd.com/read/27454216/myocarditis-in-a-patient-on-clozapine-what-did-it
#1
Sahil Munjal, Stephen Ferrando
We are presenting a case of 37-year-old male with schizoaffective disorder who developed myocarditis within 3 weeks of starting on clozapine for his treatment resistant psychosis. The patient also had a positive titer for Influenza A which makes it a diagnostic dilemma regarding the cause of his myocarditis. It may be possible that the myocarditis was caused by the Influenza A virus or synergistically exacerbated the clozapine's propensity to cause it. Currently, there are no studies establishing the link between the two etiologies...
July 25, 2016: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/27454215/catatonia-and-psychosis-related-to-epilepsy-a-case-report
#2
Laiana Quagliato, Roberto Piedade, Cristina Santana, Elie Cheniaux
Although a variety of metabolic, toxic, psychiatric, and neurologic conditions can produce catatonic syndromes, it is less widely recognized that this state may be caused by epilepsy. We present the case of a woman with catatonic behavior, which she could not recall. She also exhibited olfactory, auditory and visual hallucinations. An EEG demonstrated diffuse abnormal electrical activity, mainly on left temporal and frontal areas. Treatment with anticonvulsant drugs yielded excellent response.
July 25, 2016: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/27454214/a-guide-to-the-management-of-clozapine-related-tolerability-and-safety-concerns
#3
Leslie Citrome, Joseph P McEvoy, Stephen R Saklad
Clozapine is a highly effective antipsychotic medication, which provides a range of significant benefits for patients with schizophrenia, and is the standard of care for treatment-resistant schizophrenia as well as for reducing the risk of suicidal behaviors in schizophrenia and schizoaffective disorder. However, clozapine is widely underutilized, largely because prescribing clinicians lack experience in prescribing it and managing its adverse events (AEs). Clozapine is associated with 3 uncommon but immediately dangerous AEs, agranulocytosis, myocarditis/cardiomyopathy, and seizures, as well as AEs that may become dangerous if neglected, including weight gain, metabolic syndrome and constipation, and others that are annoying or distressing such as sedation, nighttime enuresis and hypersalivation...
July 25, 2016: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/27454213/development-and-feasibility-testing-of-a-smartphone-intervention-to-improve-adherence-to-antipsychotic-medications
#4
Julie Kreyenbuhl, Elizabeth J Record, Seth Himelhoch, Melanie Charlotte, Jessica Palmer-Bacon, Lisa B Dixon, Deborah R Medoff, Lan Li
Approximately 60% of individuals with schizophrenia do not take their antipsychotic medications as prescribed, and nonadherence is associated with exacerbation of psychotic symptoms, increased hospital and emergency room use, and increased healthcare costs. Behavioral-tailoring strategies that incorporate medication taking into the daily routine and use environmental supports have shown promise as adherence-enhancing interventions. Informed by the Information-Motivation-Behavioral (IMB) Skills Model and using the iterative process of user-centered design, we collaborated with individuals with schizophrenia and psychiatrists to develop an interactive smartphone application and web-based clinician interface, MedActive, for improving adherence to oral antipsychotic treatment...
July 25, 2016: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/27454212/meta-analysis-of-cytokine-and-chemokine-genes-in-schizophrenia
#5
Zachary D Hudson, Brian J Miller
INTRODUCTION: Immune system genes, including cytokines, are associated with schizophrenia risk. Polymorphisms in cytokine genes may also impact on blood levels of cytokines, which are altered in patients with schizophrenia. We performed a metaanalysis of case-control studies of cytokine and chemokine genes in schizophrenia that have not been considered in previous quantitative reviews. METHODS: We identified articles by systematic searches of Pub Med, PsycInfo, and ISI, and the reference lists of identified studies...
July 25, 2016: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/26780602/post-traumatic-stress-disorder-in-first-episode-psychosis-prevalence-and-related-factors
#6
Wafa Abdelghaffar, Uta Ouali, Rabaa Jomli, Yosra Zgueb, Fethi Nacef
Introduction The experience of psychosis or related treatment can be conceptualized as a traumatic event, which might lead to Post Traumatic Stress Disorder (PTSD) or PTSD syndrome which is defined as the presence of PTSD symptoms irrespective of the DSM - IV Criterion A definition of a traumatic event as an actual or threatened harm. Few studies explored the subject so far. Methods This cross - sectional study included 52 clinically stabilized patients who were hospitalized for a first psychotic episode during the two years preceding the study...
January 18, 2016: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/26780601/let-s-talk-about-psychosis
#7
Ann Steele, Paul Chadwick, Rose McCabe
BACKGROUND: Research suggests that while patients wish to talk about positive psychotic symptoms, psychiatrists may be reluctant to do so in routine outpatient consultations. AIMS: To explore the content, context and impact of discussion of positive symptoms within psychiatric consultations. METHODS: Thematic analysis was applied to first discussions of positive symptoms, and overall impact assessed on the length of the consultation and the therapeutic relationship...
January 18, 2016: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/26780600/paliperidone-palmitate-induced-retrograde-ejaculation
#8
Rohit Madan, Robert J Langenfeld, Sriram Ramaswamy
No abstract text is available yet for this article.
January 18, 2016: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/26780599/experience-of-caregiving-and-coping-in-caregivers-of-schizophrenia
#9
Nimisha Doval, Eesha Sharma, Manu Agarwal, Adarsh Tripathi, Anil Nischal
BACKGROUND: Caregivers of schizophrenia play a major role in community-based care of patients. Recent studies have shed light on positive aspects of caregiving, in contrast to caregiving burden. There is limited research on this area in India. AIMS: To assess the 'experience of caregiving' and 'coping strategies' in caregivers of patients with schizophrenia, and to study associations, if any, between them. METHOD: 102 caregivers, of out- and in-patients with schizophrenia were assessed on 'Experience of Caregiving Inventory' (ECI) and 'COPE Inventory' (COPE)...
January 18, 2016: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/26780598/among-the-severely-mentally-ill-who-responds-to-ziprasidone
#10
Nigel Bark, Nicholas Lawson, Eileen Trigoboff, Rodica Varadi, Jeffery Grace, Josie Olympia, Nighat Sindhu, Tom Watson, Mohamed El-Defrawi, Punyabrata Roy
So far, demographic variables have not consistently been found to predict clinical response to antipsychotics. This study examines some differences in response to ziprasidone, which has been shown to be effective, with a better metabolic side effect profile, but was little used in New York State Hospitals. The aim was to study state hospital patients switched to ziprasidone. The results led to questions about different responses in different groups. Subjects from state hospitals who needed a change of antipsychotic participated in this openlabel 8 week trial of up to 240 mg ziprasidone...
January 18, 2016: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/27732103/efficacy-of-the-social-cognition-training-program-in-a-sample-of-outpatients-with-schizophrenia
#11
David Gil-Sanz, Mar Fernández-Modamio, Rosario Bengochea-Seco, Marta Arrieta-Rodríguez, Gabriela Pérez-Fuentes
OBJECTIVE: Social cognition is recognized to be a deficit in individuals suffering from schizophrenia. Numerous studies have explored the relationship between social cognition and social functioning in outpatients with schizophrenia through the use of different social cognition training programs. This study examines the efficacy of the Social Cognition Training Program (PECS in Spanish) in adults with a diagnosis of schizophrenia. METHODS: Data were derived from a sample of 44 non-hospitalized adult patients who presented with a DSM-IV-TR Axis I diagnosis of schizophrenia and 39 healthy controls...
2016: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/27732102/guide-to-the-management-of-clozapine-related-tolerability-and-safety-concerns
#12
Leslie Citrome, Joseph P McEvoy, Stephen R Saklad
Clozapine is a highly effective antipsychotic medication, which provides a range of significant benefits for patients with schizophrenia, and is the standard of care for treatment-resistant schizophrenia as well as for reducing the risk of suicidal behaviors in schizophrenia and schizoaffective disorder. However, clozapine is widely underutilized, largely because prescribing clinicians lack experience in prescribing it and managing its adverse events (AEs). Clozapine is associated with three uncommon but immediately dangerous AEs-agranulocytosis, myocarditis/cardiomyopathy, and seizures-as well as AEs that may become dangerous if neglected, including weight gain, metabolic syndrome and constipation, and others that are annoying or distressing such as sedation, nighttime enuresis and hypersalivation...
2016: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/27732101/clinical-news
#13
Peter F Buckley
No abstract text is available yet for this article.
2016: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/27732100/psychotic-disorder-in-neurodegeneration-with-brain-iron-accumulation
#14
Menekse Sila Yazar, Nurhan Fistikci, Ozlem Devrim Balaban, Nezih Eradamlar, Latif Alpkan
No abstract text is available yet for this article.
2016: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/27732099/the-development-and-implementation-of-an-electronic-health-record-tool-for-monitoring-metabolic-syndrome-indices-in-patients-with-serious-mental-illness
#15
Ken Nash, Frank Ghinassi, Jaspreet S Brar, Abdulkader Alam, Mary Catherine Bohan, Kalyani Gopalan, Amie Carter, K N Roy Chengappa
OBJECTIVES: 1. A quality performance improvement (QI) project to implement an electronic screening and monitoring tool to record components of the metabolic syndrome (e-MSD) during clinic visits by persons with serious mental illness (SMI). 2. To encourage psychiatrists to use this tool in their documentation. METHODS: Working with the information technology staff, five psychiatrists developed, tested, revised and embedded the e-MSD tool into the medication management document within the electronic health record...
2016: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/27440213/rapid-rechallenge-with-clozapine-following-pronounced-myocarditis-in-a-treatment-resistant-schizophrenia-patient
#16
Pichai Ittasakul, Anthony Archer, Jennifer Kezman, Wanlop Atsariyasing, Morris B Goldman
Clozapine is an atypical antipsychotic which is often effective in patients who fail to respond to other antipsychotics, but its use carries substantial risk. Myocarditis is one of the life-threatening adverse effects, which occurs in about 1% of exposed patients. Rechallenge with clozapine is controversial, particularly shortly after the occurrence of the myocarditis, and when there is clear and convincing evidence of cardiac damage. Aggressive use of clozapine, however, may be critical for the recovery of patients early in the course of their illness...
2016: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/27440212/cariprazine-for-the-treatment-of-schizophrenia-a-review-of-this-dopamine-d3-preferring-d3-d2-receptor-partial-agonist
#17
REVIEW
Leslie Citrome
Cariprazine is an antipsychotic medication and received approval by the U.S. Food and Drug Administration for the treatment of schizophrenia in September 2015. Cariprazine is a dopamine D3 and D2 receptor partial agonist, with a preference for the D3 receptor. Cariprazine is also a partial agonist at the serotonin 5-HT1A receptor and acts as an antagonist at 5-HT2B and 5-HT2A receptors. The recommended dose range of cariprazine for the treatment of schizophrenia is 1.5-6 mg/d; the starting dose of 1.5 mg/d is potentially therapeutic...
2016: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/27440211/stressful-life-events-social-class-and-symptoms-of-schizophrenia
#18
Bernard J Gallagher, Brian J Jones, Mariana Pardes
We test to see if severe stressful life events precede onset of specific symptoms of schizophrenia. Our analyses extend to possible variations in the effect by socioeconomic status (SES) of origin. The medical records of 431 schizophrenic patients were categorized into negative and positive subtypes by application of SANS, SAPS and PANSS scales. SES was bifurcated into low-SES and high-SES groups. Stressful life events were classified into four domains. The study variables were tested by the use of chi-square analysis...
2016: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/27440210/anxiety-symptoms-in-psychotic-disorders-results-from-the-second-australian-national-mental-health-survey
#19
Peter Bosanac, Sam G Mancuso, David J Castle
BACKGROUND: The prevalence of anxiety symptoms among Australians with psychotic disorders was examined as part of the Survey of High Impact Psychosis (SHIP). METHODS: A two-phase design was used. Of 7,955 people who were screened positive for psychosis and eligible, there were 1,825 participants (18-34 years and 35-64 years) interviewed. Data were collected on symptomatology, substance use, cognitive ability, functioning, disability, physical health, mental health service utilization, medication use, education, employment and housing...
2016: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/27440209/highlights-from-the-2016-schizophrenia-international-research-society-conference-april-2-6-2016
#20
Michele Solis
The 2016 Schizophrenia International Research Society (SIRS) Conference, held in Florence, Italy, attracted approximately 1,800 attendees from over 54 countries to the stately Firenze Fiera Conference Center from April 2-6, 2016. Providing plenary sessions, special sessions, symposia, workshops, oral presentations and poster presentations, this 5th Biennial SIRS Conference focused on "Deconstructing Schizophrenia towards Targeted Treatment." In conjunction with the Schizophrenia Research Forum, a Web project of the Brain and Behavior Research Foundation, and with our thanks to the SIRS organizers and staff, we bring you the following selected highlights...
2016: Clinical Schizophrenia & related Psychoses
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