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Clinical Schizophrenia & related Psychoses

Vincenzo Prisco, Petrosino Monica, Germano Fiore, Annamaria Tridente, Antonietta La Rocca, Francesco Catapano, Michele Fabrazzo
Clozapine-related pericarditis is a rare side effect of the drug. We reported the clinical cases of two women, aged 22 and 28 years, affected by schizophrenia with pericarditis symptoms related to clozapine treatment of 200 mg/day. Clozapine was discontinued in both patients, resulting in normalization of the ECG changes, and echocardiography confirmed the progressive disappearance of the pericardial effusion. Interestingly, while inflammatory indices and pro-brain natriuretic peptide (pro-BNP) plasma levels were high in both patients, only one of them showed tachycardia, subjective chest pain, shortness of breath and dyspnea, with a clinical symptomatology suggesting a cardiac involvement...
December 20, 2016: Clinical Schizophrenia & related Psychoses
Edward Woloszyn, Nishant Whig, Eileen Trigoboff, Jeffery J Grace
The authors describe a rare case of "concealed" congenital Long QT Syndrome (LQTS) Type 3 in a patient with treatment resistant schizophrenia and no known personal or family history of cardiac disease. The patient in this Case Report had a hidden genetic condition revealed only following the essential administration of antipsychotics. As a result, this patient experienced an aborted cardiac arrest and a total of five episodes of ventricular tachycardia (VT) requiring cardioversion. Successful control of the VT occurred with an Automatic Internal Defibrillator (AID), judicious use of antipsychotic medications, and anti-arrhythmic medications...
December 20, 2016: Clinical Schizophrenia & related Psychoses
Michele Poletti, Eva Gebhardt, Andrea Raballo
Aiming at preventing transitions to more severe psychopathology and boosted by the availability of operational criteria to identify help-seeking subjects at increased risk for psychosis, research into the early prodromal phases of psychosis is attracting a growing clinical interest. Furthermore, the focus of early detection is gradually shifting from prodromal syndromes to the premorbid period. Although mainly driven by clinical-pragatic aims, such a shift is coherent with the neurodevelopmental hypothesis of schizophrenia that might offer a unifying, developmentally informed conceptual framework for early detection...
December 20, 2016: Clinical Schizophrenia & related Psychoses
Andreas S Lappas, Fiesal Jan
Psychiatric manifestations are common in patients with Wilson's Disease(WD), and they are usually correlated with neurological symptoms. However, psychotic presentation without neurological symptoms has rarely been reported. We present a case of WD involving a 34-year-old gentleman who was diagnosed at the age of 22, but due to lack of medication for approximately 5 months was admitted in a psychiatric ward with delusional thoughts of grandeur and persecution, echopraxia and echolalia. No neurological impairment, ophthalmic manifestations or liver abnormalities were identified...
December 20, 2016: Clinical Schizophrenia & related Psychoses
Marilyn J Miller, Donna M Ambrose
Missed appointments are a problem in all types of outpatient clinics including those providing mental health care. A review of literature was conducted to explore the problem of missed appointments in mental health and identify methods that have been used to improve attendance. Study results demonstrate that patients miss appointments for many reasons. Common reasons for missed appointments in the articles reviewed were the interval between scheduling and appointment day, forgetting, being discharged against medical advice, and problems with substance abuse...
December 20, 2016: Clinical Schizophrenia & related Psychoses
Peter F Buckley
No abstract text is available yet for this article.
2017: Clinical Schizophrenia & related Psychoses
Steven G Potkin, Rimal Bera, Anna Eramo, Gina Lau
OBJECTIVE: Long-acting injectable (LAI) antipsychotics improve treatment outcomes in patients with schizophrenia but are often reserved for only the most severely affected or nonadherent. Studies show cultural/racial differences in prescribing. This pilot study examined prescriber-patient interactions and cultural/racial differences in perceptions of LAIs among patients. METHODS: A linguist analyzed 120 prescriber-patient conversations representing selected patient cultural/racial subgroups (European American, African American, Latino American; n=40 each) to identify similarities and differences in conceptualization and attitudes toward LAIs...
2017: Clinical Schizophrenia & related Psychoses
Beatrice Frajo-Apor, Monika Edinger, Stefan Schmidinger, Wolfgang Fleischhacker, Alex Hofer
No abstract text is available yet for this article.
2017: Clinical Schizophrenia & related Psychoses
Paul Gorczynski, Hiren Patel, Rohan Ganguli
INTRODUCTION: Despite the importance of medication adherence for the effective treatment of type II diabetes mellitus (T2DM), little research has examined adherence with diabetes medication treatment in schizophrenia. The purpose of this systematic review was to: 1) evaluate rates of adherence and determinants of adherence with medication for T2DM in individuals with schizophrenia; and, where possible, 2) examine the relationship between medication adherence and glycemic control. METHODS: Studies were included if they presented information on dosing regimens and adherence or compliance rates for T2DM and included samples where at least 50% of the participants were individuals with schizophrenia...
2017: Clinical Schizophrenia & related Psychoses
Anatoly Kreinin, Nisham Bawakny, Michael S Ritsner
PURPOSE: This study aimed to examine the effect of add-on treatment with the neurosteroid pregnenolone (PREG) on neurocognitive dysfunctions of patients with recent-onset schizophrenia (SZ) and schizoaffective disorder (SA). METHOD: Sixty out- and inpatients that met DSM-IV criteria for SZ/SA were randomized to an 8-week, double-blind, randomized, placebo-controlled, 2-center trial. Participants received either pregnenolone (50 mg/d) or placebo added on to antipsychotic medications...
2017: Clinical Schizophrenia & related Psychoses
Urvakhsh Meherwan Mehta, C Naveen Kumar, Ganesan Venkatasubramanian, Jagadisha Thirthalli
BACKGROUND: Sensory distortions of body image commonly occur during migraine, seizures, nondominant cortical infarcts and hallucinogen abuse. METHODS: We report the case of a 30-year-old woman with paranoid schizophrenia presenting with postpartum onset multimodal sensory distortions in the absence of any neurological disorders or substance use. RESULTS: Her symptoms involved persistent facial/body metamorphopsia (distorted images) and vocal paracousis (distorted voices), in the absence of visual hallucinations, illusions or agnosia...
2017: Clinical Schizophrenia & related Psychoses
Sahil Munjal, Stephen Ferrando
We are presenting a case of 37-year-old male with schizoaffective disorder who developed myocarditis within 3 weeks of starting on clozapine for his treatment resistant psychosis. The patient also had a positive titer for Influenza A which makes it a diagnostic dilemma regarding the cause of his myocarditis. It may be possible that the myocarditis was caused by the Influenza A virus or synergistically exacerbated the clozapine's propensity to cause it. Currently, there are no studies establishing the link between the two etiologies...
July 25, 2016: Clinical Schizophrenia & related Psychoses
Laiana Quagliato, Roberto Piedade, Cristina Santana, Elie Cheniaux
Although a variety of metabolic, toxic, psychiatric, and neurologic conditions can produce catatonic syndromes, it is less widely recognized that this state may be caused by epilepsy. We present the case of a woman with catatonic behavior, which she could not recall. She also exhibited olfactory, auditory and visual hallucinations. An EEG demonstrated diffuse abnormal electrical activity, mainly on left temporal and frontal areas. Treatment with anticonvulsant drugs yielded excellent response.
July 25, 2016: Clinical Schizophrenia & related Psychoses
Leslie Citrome, Joseph P McEvoy, Stephen R Saklad
Clozapine is a highly effective antipsychotic medication, which provides a range of significant benefits for patients with schizophrenia, and is the standard of care for treatment-resistant schizophrenia as well as for reducing the risk of suicidal behaviors in schizophrenia and schizoaffective disorder. However, clozapine is widely underutilized, largely because prescribing clinicians lack experience in prescribing it and managing its adverse events (AEs). Clozapine is associated with 3 uncommon but immediately dangerous AEs, agranulocytosis, myocarditis/cardiomyopathy, and seizures, as well as AEs that may become dangerous if neglected, including weight gain, metabolic syndrome and constipation, and others that are annoying or distressing such as sedation, nighttime enuresis and hypersalivation...
July 25, 2016: Clinical Schizophrenia & related Psychoses
Julie Kreyenbuhl, Elizabeth J Record, Seth Himelhoch, Melanie Charlotte, Jessica Palmer-Bacon, Lisa B Dixon, Deborah R Medoff, Lan Li
Approximately 60% of individuals with schizophrenia do not take their antipsychotic medications as prescribed, and nonadherence is associated with exacerbation of psychotic symptoms, increased hospital and emergency room use, and increased healthcare costs. Behavioral-tailoring strategies that incorporate medication taking into the daily routine and use environmental supports have shown promise as adherence-enhancing interventions. Informed by the Information-Motivation-Behavioral (IMB) Skills Model and using the iterative process of user-centered design, we collaborated with individuals with schizophrenia and psychiatrists to develop an interactive smartphone application and web-based clinician interface, MedActive, for improving adherence to oral antipsychotic treatment...
July 25, 2016: Clinical Schizophrenia & related Psychoses
Zachary D Hudson, Brian J Miller
INTRODUCTION: Immune system genes, including cytokines, are associated with schizophrenia risk. Polymorphisms in cytokine genes may also impact on blood levels of cytokines, which are altered in patients with schizophrenia. We performed a metaanalysis of case-control studies of cytokine and chemokine genes in schizophrenia that have not been considered in previous quantitative reviews. METHODS: We identified articles by systematic searches of Pub Med, PsycInfo, and ISI, and the reference lists of identified studies...
July 25, 2016: Clinical Schizophrenia & related Psychoses
Wafa Abdelghaffar, Uta Ouali, Rabaa Jomli, Yosra Zgueb, Fethi Nacef
Introduction The experience of psychosis or related treatment can be conceptualized as a traumatic event, which might lead to Post Traumatic Stress Disorder (PTSD) or PTSD syndrome which is defined as the presence of PTSD symptoms irrespective of the DSM - IV Criterion A definition of a traumatic event as an actual or threatened harm. Few studies explored the subject so far. Methods This cross - sectional study included 52 clinically stabilized patients who were hospitalized for a first psychotic episode during the two years preceding the study...
January 18, 2016: Clinical Schizophrenia & related Psychoses
Ann Steele, Paul Chadwick, Rose McCabe
BACKGROUND: Research suggests that while patients wish to talk about positive psychotic symptoms, psychiatrists may be reluctant to do so in routine outpatient consultations. AIMS: To explore the content, context and impact of discussion of positive symptoms within psychiatric consultations. METHODS: Thematic analysis was applied to first discussions of positive symptoms, and overall impact assessed on the length of the consultation and the therapeutic relationship...
January 18, 2016: Clinical Schizophrenia & related Psychoses
Rohit Madan, Robert J Langenfeld, Sriram Ramaswamy
No abstract text is available yet for this article.
January 18, 2016: Clinical Schizophrenia & related Psychoses
Nimisha Doval, Eesha Sharma, Manu Agarwal, Adarsh Tripathi, Anil Nischal
BACKGROUND: Caregivers of schizophrenia play a major role in community-based care of patients. Recent studies have shed light on positive aspects of caregiving, in contrast to caregiving burden. There is limited research on this area in India. AIMS: To assess the 'experience of caregiving' and 'coping strategies' in caregivers of patients with schizophrenia, and to study associations, if any, between them. METHOD: 102 caregivers, of out- and in-patients with schizophrenia were assessed on 'Experience of Caregiving Inventory' (ECI) and 'COPE Inventory' (COPE)...
January 18, 2016: Clinical Schizophrenia & related Psychoses
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