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Clinical Schizophrenia & related Psychoses

Paul Gorczynski, Hiren Patel, Rohan Ganguli
INTRODUCTION: Despite the importance of medication adherence for the effective treatment of type II diabetes mellitus (T2DM), little research has examined adherence with diabetes medication treatment in schizophrenia. The purpose of this systematic review was to: 1) evaluate rates of adherence and determinants of adherence with medication for T2DM in individuals with schizophrenia; and, where possible, 2) examine the relationship between medication adherence and glycemic control. METHODS: Studies were included if they presented information on dosing regimens and adherence or compliance rates for T2DM and included samples where at least 50% of the participants were individuals with schizophrenia...
2017: Clinical Schizophrenia & related Psychoses
Vincenzo Prisco, Petrosino Monica, Germano Fiore, Annamaria Tridente, Antonietta La Rocca, Francesco Catapano, Michele Fabrazzo
Clozapine-related pericarditis is a rare side effect of the drug. We reported the clinical cases of two women, aged 22 and 28 years, affected by schizophrenia with pericarditis symptoms related to clozapine treatment of 200 mg/day. Clozapine was discontinued in both patients, resulting in normalization of the ECG changes, and echocardiography confirmed the progressive disappearance of the pericardial effusion. Interestingly, while inflammatory indices and pro-brain natriuretic peptide (pro-BNP) plasma levels were high in both patients, only one of them showed tachycardia, subjective chest pain, shortness of breath and dyspnea, with a clinical symptomatology suggesting a cardiac involvement...
December 20, 2016: Clinical Schizophrenia & related Psychoses
Edward Woloszyn, Nishant Whig, Eileen Trigoboff, Jeffery J Grace
The authors describe a rare case of "concealed" congenital Long QT Syndrome (LQTS) Type 3 in a patient with treatment resistant schizophrenia and no known personal or family history of cardiac disease. The patient in this Case Report had a hidden genetic condition revealed only following the essential administration of antipsychotics. As a result, this patient experienced an aborted cardiac arrest and a total of five episodes of ventricular tachycardia (VT) requiring cardioversion. Successful control of the VT occurred with an Automatic Internal Defibrillator (AID), judicious use of antipsychotic medications, and anti-arrhythmic medications...
December 20, 2016: Clinical Schizophrenia & related Psychoses
Michele Poletti, Eva Gebhardt, Andrea Raballo
Aiming at preventing transitions to more severe psychopathology and boosted by the availability of operational criteria to identify help-seeking subjects at increased risk for psychosis, research into the early prodromal phases of psychosis is attracting a growing clinical interest. Furthermore, the focus of early detection is gradually shifting from prodromal syndromes to the premorbid period. Although mainly driven by clinical-pragatic aims, such a shift is coherent with the neurodevelopmental hypothesis of schizophrenia that might offer a unifying, developmentally informed conceptual framework for early detection...
December 20, 2016: Clinical Schizophrenia & related Psychoses
Andreas S Lappas, Fiesal Jan
Psychiatric manifestations are common in patients with Wilson's Disease(WD), and they are usually correlated with neurological symptoms. However, psychotic presentation without neurological symptoms has rarely been reported. We present a case of WD involving a 34-year-old gentleman who was diagnosed at the age of 22, but due to lack of medication for approximately 5 months was admitted in a psychiatric ward with delusional thoughts of grandeur and persecution, echopraxia and echolalia. No neurological impairment, ophthalmic manifestations or liver abnormalities were identified...
December 20, 2016: Clinical Schizophrenia & related Psychoses
Marilyn J Miller, Donna M Ambrose
Missed appointments are a problem in all types of outpatient clinics including those providing mental health care. A review of literature was conducted to explore the problem of missed appointments in mental health and identify methods that have been used to improve attendance. Study results demonstrate that patients miss appointments for many reasons. Common reasons for missed appointments in the articles reviewed were the interval between scheduling and appointment day, forgetting, being discharged against medical advice, and problems with substance abuse...
December 20, 2016: Clinical Schizophrenia & related Psychoses
Sahil Munjal, Stephen Ferrando
We are presenting a case of 37-year-old male with schizoaffective disorder who developed myocarditis within 3 weeks of starting on clozapine for his treatment resistant psychosis. The patient also had a positive titer for Influenza A which makes it a diagnostic dilemma regarding the cause of his myocarditis. It may be possible that the myocarditis was caused by the Influenza A virus or synergistically exacerbated the clozapine's propensity to cause it. Currently, there are no studies establishing the link between the two etiologies...
July 25, 2016: Clinical Schizophrenia & related Psychoses
Laiana Quagliato, Roberto Piedade, Cristina Santana, Elie Cheniaux
Although a variety of metabolic, toxic, psychiatric, and neurologic conditions can produce catatonic syndromes, it is less widely recognized that this state may be caused by epilepsy. We present the case of a woman with catatonic behavior, which she could not recall. She also exhibited olfactory, auditory and visual hallucinations. An EEG demonstrated diffuse abnormal electrical activity, mainly on left temporal and frontal areas. Treatment with anticonvulsant drugs yielded excellent response.
July 25, 2016: Clinical Schizophrenia & related Psychoses
Leslie Citrome, Joseph P McEvoy, Stephen R Saklad
Clozapine is a highly effective antipsychotic medication, which provides a range of significant benefits for patients with schizophrenia, and is the standard of care for treatment-resistant schizophrenia as well as for reducing the risk of suicidal behaviors in schizophrenia and schizoaffective disorder. However, clozapine is widely underutilized, largely because prescribing clinicians lack experience in prescribing it and managing its adverse events (AEs). Clozapine is associated with 3 uncommon but immediately dangerous AEs, agranulocytosis, myocarditis/cardiomyopathy, and seizures, as well as AEs that may become dangerous if neglected, including weight gain, metabolic syndrome and constipation, and others that are annoying or distressing such as sedation, nighttime enuresis and hypersalivation...
July 25, 2016: Clinical Schizophrenia & related Psychoses
Julie Kreyenbuhl, Elizabeth J Record, Seth Himelhoch, Melanie Charlotte, Jessica Palmer-Bacon, Lisa B Dixon, Deborah R Medoff, Lan Li
Approximately 60% of individuals with schizophrenia do not take their antipsychotic medications as prescribed, and nonadherence is associated with exacerbation of psychotic symptoms, increased hospital and emergency room use, and increased healthcare costs. Behavioral-tailoring strategies that incorporate medication taking into the daily routine and use environmental supports have shown promise as adherence-enhancing interventions. Informed by the Information-Motivation-Behavioral (IMB) Skills Model and using the iterative process of user-centered design, we collaborated with individuals with schizophrenia and psychiatrists to develop an interactive smartphone application and web-based clinician interface, MedActive, for improving adherence to oral antipsychotic treatment...
July 25, 2016: Clinical Schizophrenia & related Psychoses
Zachary D Hudson, Brian J Miller
INTRODUCTION: Immune system genes, including cytokines, are associated with schizophrenia risk. Polymorphisms in cytokine genes may also impact on blood levels of cytokines, which are altered in patients with schizophrenia. We performed a metaanalysis of case-control studies of cytokine and chemokine genes in schizophrenia that have not been considered in previous quantitative reviews. METHODS: We identified articles by systematic searches of Pub Med, PsycInfo, and ISI, and the reference lists of identified studies...
July 25, 2016: Clinical Schizophrenia & related Psychoses
Wafa Abdelghaffar, Uta Ouali, Rabaa Jomli, Yosra Zgueb, Fethi Nacef
Introduction The experience of psychosis or related treatment can be conceptualized as a traumatic event, which might lead to Post Traumatic Stress Disorder (PTSD) or PTSD syndrome which is defined as the presence of PTSD symptoms irrespective of the DSM - IV Criterion A definition of a traumatic event as an actual or threatened harm. Few studies explored the subject so far. Methods This cross - sectional study included 52 clinically stabilized patients who were hospitalized for a first psychotic episode during the two years preceding the study...
January 18, 2016: Clinical Schizophrenia & related Psychoses
Ann Steele, Paul Chadwick, Rose McCabe
BACKGROUND: Research suggests that while patients wish to talk about positive psychotic symptoms, psychiatrists may be reluctant to do so in routine outpatient consultations. AIMS: To explore the content, context and impact of discussion of positive symptoms within psychiatric consultations. METHODS: Thematic analysis was applied to first discussions of positive symptoms, and overall impact assessed on the length of the consultation and the therapeutic relationship...
January 18, 2016: Clinical Schizophrenia & related Psychoses
Rohit Madan, Robert J Langenfeld, Sriram Ramaswamy
No abstract text is available yet for this article.
January 18, 2016: Clinical Schizophrenia & related Psychoses
Nimisha Doval, Eesha Sharma, Manu Agarwal, Adarsh Tripathi, Anil Nischal
BACKGROUND: Caregivers of schizophrenia play a major role in community-based care of patients. Recent studies have shed light on positive aspects of caregiving, in contrast to caregiving burden. There is limited research on this area in India. AIMS: To assess the 'experience of caregiving' and 'coping strategies' in caregivers of patients with schizophrenia, and to study associations, if any, between them. METHOD: 102 caregivers, of out- and in-patients with schizophrenia were assessed on 'Experience of Caregiving Inventory' (ECI) and 'COPE Inventory' (COPE)...
January 18, 2016: Clinical Schizophrenia & related Psychoses
Nigel Bark, Nicholas Lawson, Eileen Trigoboff, Rodica Varadi, Jeffery Grace, Josie Olympia, Nighat Sindhu, Tom Watson, Mohamed El-Defrawi, Punyabrata Roy
So far, demographic variables have not consistently been found to predict clinical response to antipsychotics. This study examines some differences in response to ziprasidone, which has been shown to be effective, with a better metabolic side effect profile, but was little used in New York State Hospitals. The aim was to study state hospital patients switched to ziprasidone. The results led to questions about different responses in different groups. Subjects from state hospitals who needed a change of antipsychotic participated in this openlabel 8 week trial of up to 240 mg ziprasidone...
January 18, 2016: Clinical Schizophrenia & related Psychoses
Pichai Ittasakul, Anthony Archer, Jennifer Kezman, Wanlop Atsariyasing, Morris B Goldman
Clozapine is an atypical antipsychotic which is often effective in patients who fail to respond to other antipsychotics, but its use carries substantial risk. Myocarditis is one of the life-threatening adverse effects, which occurs in about 1% of exposed patients. Rechallenge with clozapine is controversial, particularly shortly after the occurrence of the myocarditis, and when there is clear and convincing evidence of cardiac damage. Aggressive use of clozapine, however, may be critical for the recovery of patients early in the course of their illness...
2016: Clinical Schizophrenia & related Psychoses
Leslie Citrome
Cariprazine is an antipsychotic medication and received approval by the U.S. Food and Drug Administration for the treatment of schizophrenia in September 2015. Cariprazine is a dopamine D3 and D2 receptor partial agonist, with a preference for the D3 receptor. Cariprazine is also a partial agonist at the serotonin 5-HT1A receptor and acts as an antagonist at 5-HT2B and 5-HT2A receptors. The recommended dose range of cariprazine for the treatment of schizophrenia is 1.5-6 mg/d; the starting dose of 1.5 mg/d is potentially therapeutic...
2016: Clinical Schizophrenia & related Psychoses
Bernard J Gallagher, Brian J Jones, Mariana Pardes
We test to see if severe stressful life events precede onset of specific symptoms of schizophrenia. Our analyses extend to possible variations in the effect by socioeconomic status (SES) of origin. The medical records of 431 schizophrenic patients were categorized into negative and positive subtypes by application of SANS, SAPS and PANSS scales. SES was bifurcated into low-SES and high-SES groups. Stressful life events were classified into four domains. The study variables were tested by the use of chi-square analysis...
2016: Clinical Schizophrenia & related Psychoses
Peter Bosanac, Sam G Mancuso, David J Castle
BACKGROUND: The prevalence of anxiety symptoms among Australians with psychotic disorders was examined as part of the Survey of High Impact Psychosis (SHIP). METHODS: A two-phase design was used. Of 7,955 people who were screened positive for psychosis and eligible, there were 1,825 participants (18-34 years and 35-64 years) interviewed. Data were collected on symptomatology, substance use, cognitive ability, functioning, disability, physical health, mental health service utilization, medication use, education, employment and housing...
2016: Clinical Schizophrenia & related Psychoses
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