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Recent Patents on Biotechnology

Naveen Patel, Dhananjai Rai, Soni Shivam, Shraddha Shahane, Umesh Mishra
Background and sources: Lipase enzyme is a naturally occurring enzyme found in the stomach and pancreatic juice. They function is to digests fats and lipids, helping to maintain correct gallbladder function. Lipase is the one such widely used and versatile enzyme. These enzymes are obtained from animals, plants and as well as from several microorganisms and are sufficiently stable. These are considered as nature's catalyst but commercially only microbial lipases are being used significantly. Applications: They found enormous application in the industries of fat and oil processing, oleochemical industry, food industry, detergents, pulp and paper industry, detergents, environment management, tea processing, biosensors and cosmetics and perfumery...
October 28, 2018: Recent Patents on Biotechnology
Tania Paul, Abhijit Mondal, Tarun Kanti Bandyopadhyay
BACKGROUND: L-ASNase (L-asparagine aminohydrolase EC is used for the conversion of L-asparagine to L-aspartic acid and ammonia and also it was found as an agent of chemotherapeutic property. It is known as an anti-cancer agent and recently it has received an immense attention. The various microorganisms have ability to secrete the L-ASNase. It is famous world-wide as anti-tumour medicine for acute lymphoblastic leukemia and lymphosarcoma. L-ASNase helps in deamination of Asparagine and Glutamine...
October 12, 2018: Recent Patents on Biotechnology
Anirban Banik, Tarun Kanti Bandyopadhyay, Sushant Kumar Biswal
BACKGROUND: Membrane filtration process produced good quality of permeate flux due to which it is used in different industries like dairy, pharmaceutical, sugar, starch and sweetener industry, bio separation, purification of biomedical materials, and downstream polishing etc. The cross flow mode of operation has also been used to improve the quality of the Rubber Industrial effluent of Tripura, India. METHODS: The Computational Fluid Dynamics (CFD) simulation of the cross flow membrane is done by using ANSYS Fluent 6...
September 24, 2018: Recent Patents on Biotechnology
Amin Jablaoui, Aicha Kriaa, Nizar Akermi, Hela Mkaouar, Ali Gargouri, Emmanuelle Maguin, Moez Rhimi
BACKGROUND: Serine proteases have long been recognized to play key roles in various physiological processes. However, their disequilibrium can be linked to several diseases. Taking into account their wide diversity and specificity, they have been actively investigated by many industrial, academic and pharmaceutical industries. OBJECTIVE: This review aims to provide a concise analysis of the described serine proteases as well as their relevant biotechnological and therapeutic applications...
September 24, 2018: Recent Patents on Biotechnology
Ram Balak Mahto, Mukesh Yadav, Soumya Sasmal
BACKGROUND: Pectinase enzyme has immense industrial prospects in food and beverage industries. We mentioned the patents relating to pectinase used in various industries. OBJECTIVE: In this study, the optimization of the process parameters for the pectinase production was carried out from Bacillus Subtilis MF447840.1 using submerged fermentation. METHOD: 2% (OD600 nm=0.1) of seed culture was inoculated in production media. The production media components used for this study was 1 g/l of pectin, 0...
September 16, 2018: Recent Patents on Biotechnology
Naveen Patel, Shraddha Shahane, Soni Shivam, Ria Majumdar, Umesh Mishra
Background and Source: Laccase belongs to the blue multi-copper oxidases, which are widely distributed in fungi and higher plants. It is present in Ascomycetes, Deuteromycetes, and Basidiomycetes and found abundantly in white-rot fungi. APPLICATIONS: Laccase enzyme because of their potential have acquired more importance and application in the area of textile, pulp and paper, and food industry. Recently, it is being used in developing biosensors for detection and removal of toxic pollutants, designing of biofuel cells and medical diagnostics tool...
August 21, 2018: Recent Patents on Biotechnology
Suman Debnath, Anirban Banik, TarunKanti Bandyopadhyay, Apu Kumar Saha
BACKGROUND: The non-Newtonian pseudoplastic liquid flow through different types of the bend is more complicated compared to the simple straight pipe as the bends are associated with various curve geometry. Bends have wide application in bioengineering, biotechnology and biomedical such as study biofluids, blood rheology study, the design of medical equipment like equipment measuring the cholesterol etc. Methods:The papers deal with the estimation of loss coefficient and frictional pressure drop of Newtonian and non-Newtonian pseudoplastic fluid flow through the different bend of 0...
August 20, 2018: Recent Patents on Biotechnology
Lidia Audrey Rocha Valadas Marques, Keniesd Sampaio Mendonca, Rosueti Diogenes de Oliveira Filho, Edilson Martins Rodrigues Neto, Joao Hildo de Carvalho Furtado, Marta Maria de Franca Fonteles, Leandro Maciel Uchoa Gadelha, Nicole de Mello Fiallo, Ana Cristina de Mello Fiallos
BACKGROUND: Propolis is a resinous complex produced by Apis mellifera L. bees whose variety of pharmacological properties is resulting from the complexity of its composition. In dentistry, propolis is used on the prevention of oral diseases such as dental caries and gingivitis. Prospective studies in intellectual property banks are important to increase market competitiveness and thus generate new products in the various research areas. In this way, investments in patents play an important role in the technological and economic development of a country...
August 14, 2018: Recent Patents on Biotechnology
Mariana Campos-da-Paz, Jose Garrofe Dorea, Alexsandro Sobreira Galdino, Zulmira Guerrero Marques Lacava, Maria de Fatima Menezes Almeida Santos
Carcinoembryonic antigen (CEA) is a prognostic marker in colorectal cancer (CRC) for tumor diagnosis and monitoring response to therapy. High CEA levels are specifically associated with CRC progression and liver metastasis. Due to its differential expression between cancer and healthy tissues, and between positive and negative lymph nodes CEA has been explored for new cancer therapy and diagnosis approaches. We revised the literature on CEA role in CRC as well as the patents relating to CEA targeting for cancer management...
July 30, 2018: Recent Patents on Biotechnology
Emilia Akil, Elisa d'Avila Costa Cavalcanti, Sabrina Dias de Oliveira, Priscilla Filomena Fonseca Amaral, Denise Maria Guimaraes Freire, Alexandre Guedes Torres
BACKGROUND: Lipid modification results in several benefits for the food industry, biotechnology advances and human health. Customizing bioactive lipids is very appealing because it improves the product's nutritional quality. Lipases are sustainable biocatalysts that can be reused, show selectivity towards substrates and reactions occur in mild conditions. OBJECTIVES: We aimed at systematically searching for patents deposited worldwide, that approached the production of structured lipids by using lipases as biocatalysts...
June 3, 2018: Recent Patents on Biotechnology
Debabrata Pradhan, Lala Behari Sukla, Niharbala Devi, Sridhara Acharya
BACKGROUND: The waterborne or airborne radon causes carcinogenesis in the human bodies due to the continuous decay of α- and β- particles. The health risks related to radioactive radon instigate to develop an advanced technology for its removal from the environment. There are two standard tech-niques, such as aeration and activated carbon filtration, available for its removal. However, both of them face different technological drawbacks resulting in the processes either inefficient or inappropriate for the purpose...
May 1, 2018: Recent Patents on Biotechnology
Ingridi Souza Sene, Vladimir Costa Silva, Gisele Elias Nunes Pauli, Ivan Helmuth Bechtold, Livio Cesar Cunha Nunes, Carla Eiras, Carlos Henrique Nery Costa
BACKGROUND: Interleukin-6 (IL-6) is a multifunctional cytokine that plays a crucial role not only in the immune system, but also in numerous biological processes. Elevated IL-6 levels have been observed in many types of cancer and inflammatory diseases. Among the techniques that have been used to quantify IL-6, a Lateral Flow Assay (LFA) is one of the most promising. OBJECTIVE: The objective of this study was to perform a technological and scientific exploration of the development of a LFA for IL-6...
March 20, 2018: Recent Patents on Biotechnology
Paulraj Ponnaiah, Nagiah Vnoothenei, Muruganandham Chandramohan, Mohamed Javad Pazhayakath Thevarkattil
BACKGROUND: Polyhydroxyalkanoates are bio-based, biodegradable naturally occurring polymers produced by a wide range of organisms, from bacteria to higher mammals. The properties and biocompatibility of PHA make it possible for a wide spectrum of applications. In this context, we analyze the potential applications of PHA in biomedical science by exploring the global trend through the patent survey. The survey suggests that PHA is an attractive candidate in such a way that their applications are widely distributed in the medical industry, drug delivery system, dental material, tissue engineering, packaging material as well as other useful products...
January 30, 2018: Recent Patents on Biotechnology
Monica Scali, Andrea Zifferero, Rita Vignani
BACKGROUND: The Eurasian grapevine is the most widespread fruit crop in the world. Numerous studies have focused on clarifying the events of domestication and the geographical areas in which they occurred. OBJECTIVES: In order to add upon information on the process of grapevine domestication, the distribution and genetic diversity of a small, wild population localized in Poggio Ghiaccio Forte, an archaeological site in Maremma (Southern Tuscany), were assessed. In a preliminary survey the wild forms of Vitis vinifera L...
January 24, 2018: Recent Patents on Biotechnology
Ashok Kumar, Satyabrata Bag, Bhabatosh Das
BACKGROUND: Genomic islands (GIs) are discrete segments of mobile DNA with defined boundaries according to recent patents, acquired in the bacterial genome from another organism by horizontal gene transfer during the course of evolution. GIs contribute significantly to virulence, disease development, antimicrobial resistance and metabolic process. OBJECTIVE: The present study focuses on the development of a vector based genetic tool carrying selectable and counter-selectable markers, in order to flag the GIs in the bacterial chromosome and monitor their stability under in vitro and in vivo conditions...
2018: Recent Patents on Biotechnology
Leticia Perez-Diaz, Berenice A Dedavid, Sergio A Gehrke
BACKGROUND: The topographical surficial characteristics and properties of materials can induce different cell reactions regarding the viability and adhesion according to the recent patents. The aim of this in vitro experimental study was to evaluate the viability and adhesion of fibroblastic cells seeded on titanium disks with different surface topography. In addition, we revised all patents related to surface treatment of dental implants. METHODS: Fibroblast cells were cultured on 6 surface models: mA disks corresponding to titanium surfaces without additional treatment (machined surface) were compared with mB disks, where surfaces were sandblasting etching using aluminum oxide; mC disks where titanium oxide was used for sandblasting etching; mD disks where triple acid conditioning was used; mE disks with laser treated surface; and mF disks which were made of titanium powder by a sintering process...
2018: Recent Patents on Biotechnology
Tasha R Serna-Gallegos, Christopher J La-Fargue, Krishnansu S Tewari
OBJECTIVE: Fully humanized monoclonal antibodies have revolutionized the treatment of many solid tumors, including ovarian, lung, colorectal, and breast cancer. Among the most widely used monoclonal antibodies in clinical oncology are cetuximab, trastuzumab, rituximab, and bevacizumab. METHODS: This is a review article focusing on the drug patents for cetuximab, trastuzumab, rituximab, and bevacizumab. RESULTS: These four monoclonal antibodies are used in both first and second line treatment regimens for multiple common malignancies...
2018: Recent Patents on Biotechnology
Thais P P de Souza, Reysla M da S Mariano, Mariana S Vieira, Suliana F V Andrade, Renato R Godoi, Ana Flavia A Goncalves, Luciana P Naves, William J N Lima, Daniel B Goncalves, Mariana Campos-da-Paz, Alexsandro S Galdino
BACKGROUND: Phytases are enzymes capable of degrading phytic acid and are used in animal feed supplementation in order to improve digestibility through the release of minerals such as phosphorus. Recent inventions show interest in production and optimization of recombinant phytases with biochemical and physicochemical characteristics promising for animal feed industry. METHODS: This review article is focused on relevant patents of promising phytases, together with the commonly used expression systems for their production and tools currently employed to generate new phytases...
2018: Recent Patents on Biotechnology
Yousseria M H Shetaia, Ashraf F El-Baz, Ahmed ElMekawy
BACKGROUND: The review of literature and patents shows that enhancing the polygalacturonase (PG) production and activity are still required to fulfill the increasing demands. METHODS: A dual optimization process, which involved Plackett-Burman design (PBD), with seven factors, and response surface methodology, was applied to optimize the production of extracellular PG enzyme produced by a novel strain of Aspergillus flavus isolated from rotten orange fruit. The fungal PG was purified and biochemically characterized...
2018: Recent Patents on Biotechnology
Haji Shirinzadeh, Abolfazl Yazdanpanah, Dimitrios Karponis, Behzad Aghabarari, Mohammad Tahmasbi, Alexander Seifalian, Masoud Mozafari
BACKGROUND: Glucose sensors have been extensively researched in patent studies and manufactured a tool for clinical diabetes diagnosis. Although some kinds of electrochemical enzymatic glucose sensors have been commercially successful, there is still room for improvement, in selectivity and reliability of these sensors. Because of the intrinsic disadvantages of enzymes, such as high fabrication cost and poor stability, non-enzymatic glucose sensors have recently been promoted as next generation diagnostic tool due to their relatively low cost, high stability, prompt response, and accuracy...
2018: Recent Patents on Biotechnology
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