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Recent Patents on Biotechnology

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https://www.readbyqxmd.com/read/27903220/santavac-%C3%A2-a-novel-universal-antigen-composition-for-developing-cancer-vaccines
#1
Petr Genrievich Lokhov, Elena Evgenevna Balashova
BACKGROUND: Development of a universal cancer vaccine for the prevention of all cancers has been under development for many years. Antiangiogenic cancer vaccines elicit immune responses with the potential of destroying tumor vasculature endothelial cells without affecting vasculature integrity in normal tissues. The methods used in the development of antigen compositions comprising these vaccines have been recently improved and described in this report in the context of SANTAVAC ™ development - the first cancer vaccine based on endothelial cell heterogeneity...
November 30, 2016: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/27881055/patents-in-nanobiotechnology-a-cross-jurisdictional-approach
#2
Padmavati Manchikanti, Shailaja Gnaneshwar, B Ramesh Kumar
BACKGROUND: Bio nanomaterials create new opportunities for advancing medical sciences and diseases treatment in relation to human health care. Innovations in the use of such nanomaterials and nanodevices can lead to significant improvements in the use of drugs/devices. OBJECTIVE: The present study attempts to analyse patenting trends in different areas and compare the patentability criteria and the disclosure norms for nanobiotechnology inventions in countries such as US, EU and India in the field of diagnostics and therapeutics...
November 22, 2016: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/27842483/patents-on-therapeutic-and-cosmetic-applications-of-bioactives-of-crocus-sativus-l-and-their-production-through-synthetic-biology-methods-a-review
#3
Mitali Nitin Dawalbhakta, Manasi Alok Telang
BACKGROUND: Saffron (Crocus sativus L.) has a long history of use as a food additive and a traditional medicine for treating a number of disorders. Prominent bioactives of saffron are crocin, crocetin and safranal. OBJECTIVE: The aim of this study was to carry out an extensive patent search to collect information on saffron bioactives and their derivatives as therapeutic and cosmeceutical agents. All patents related to the area of interest published globally till date have been reviewed...
November 14, 2016: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/27745543/an-overview-of-computational-and-experimental-methods-for-designing-novel-proteins
#4
Khushboo Gualti, Krishna Mohan Poluri
BACKGROUND: Unraveling the comprehensive networks of molecular signaling in various cellular processes and redesign/rewire them as per human wish is the ultimate dream of the biomedical researchers. Recent advances in the experimental and computational biophysics have provided us with enormous amount of protein sequences and a wide variety of structural information. Protein engineering is a fledging field and a creative process to design the target proteins or signaling networks with desirable structure and functions...
October 13, 2016: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/27686329/heavy-metal-concentrations-in-some-edible-vegetables-a-case-study-in-uyo-and-ibesikpo-asutan-local-government-areas-of-akwa-ibom-state
#5
Okpako Felix Ogbemudia, Iziegbe Lucky Igbinosun, Mathias Rufus Ubom, Tochi Grace Chilaka
BACKGROUND: This study assessed the level of heavy metals (Zn, Cu, Mn, Hg and Fe) accumulation in leaves of five vegetables viz: Telfairia occidentalis, Heinsia crinita, Gnetum africanum, Talinum triangulare and Vernonia amygdalina planted in different gardens in Ibesikpo Asutan and Uyo L.G.As in Akwa Ibom State, Nigeria using standard scientific methods. METHODS: Soil samples were obtained at a depth of 0 - 10 cm each at the base of each vegetable using soil auger...
September 27, 2016: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/27671490/cardioprotector-activity-of-an-esteroidal-saponin-a-scientific-and-technological-prospection
#6
Hercília Maria Lins Rolim, Michely Laiany Vieira Moura
Diosgenin (3b-hydroxy-5-spirostene), saponin is a steroid with wide therapeutic application in different areas, with cardiovascular protective action and performance in the control of dyslipidemia. The objective of study was to conduct a systematic review of this Diosgenina, its pharmaceutical applications and the outlook on the application in Cardiovascular System diseases. Periodicals bases, such as ScienceDirect, PubMed and Virtual Health Library, were used, as well as technological basis of European Patent Office, World Intellectual Property Organization, United States Patent and Trademark Office and data bank from Brazilian National Institute of Industrial Property...
September 26, 2016: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/27659132/local-anaesthetic-effect-of-methanolic-leves-extract-of-lannea-schimperi-hoschst-ex-rich-eng
#7
Hudu Garba Mikail, David Dezi Akumka, Muhammed Adamu
BACKGROUND: Local anaesthetics provide relief from pain when applied locally to nerve tissue by blocking conduction of sensory nerve impulse from the receptor to the brain cortex. OBJECTIVE: This study aimed at evaluating local anaesthetic activity of the methanolic leaves extract of Lannea schimperi. METHODS: Six groups of five animals were used; groups I-IV were used for intracutaneous wheal test in guinea pigs for infiltration anaesthesia, while group V and VI were used for guinea pig corneal reflex method of surface anaesthesia...
September 22, 2016: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/27659131/heavy-metal-concentration-in-periwinkle-tympanotomus-fuscatus-in-iko-river-estuary-nigeria
#8
Nsikak O Abiaobo, Sifon Udi, Ofonmbuk I Obot
The concentration of five heavy metals; Cadmium (Cd), Copper (Cu), Lead (Pb), Mercury (Hg) and Zinc (Zn) in the tissues of periwinkle; Typanotonus fuscatus from Iko River Estuary were determined using UNICAM Solar Atomic Absorption Spectrophotometer 969 model. The results showed that Cd ranged from 68.83 - 130.5mg/kg with a mean value of 104.47±23.85mg/kg, Cu ranged from 34.9 - 73.62mg/kg with a mean value of 57.70±17.19mg/kg, Pb ranged between 54.27 - 102.54mg/kg with a mean value of 85.03±18.52mg/kg, Mercury ranged from 0...
September 22, 2016: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/27652612/bacteriophage-for-mitigation-of-multiple-drug-resistant-biofilm-forming-pathogens
#9
Shilpa Deshpande Kaistha, Pramila Devi Umrao
BACKGROUND: Microbial communities encased in exopolymeric substances (EPS) attached to suitable substrate as biofilms show heightened resistance to multiple drugs including antibiotics. One promising control strategy in dealing with the ever mounting problem of antibiotic resistance amongst biofilm forming bacterial pathogens is the use of biological agents. OBJECTIVE: This review focuses on the development of bacteriophages as means of disrupting biofilm forming pathogens and hence mitigation of multiple drug resistant organisms...
September 19, 2016: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/27652611/natural-compounds-for-overcoming-multidrug-resistance-in-mycobacteria
#10
Zeeshan Fatima, Sharda Sharma, Saif Hameed
BACKGROUND: Tuberculosis caused by Mycobacterium tuberculosis (MTB) is currently a major health concern due to its growing mortality rates around the world. The known anti-TB drugs although are available for the treatment but it produces adverse side effects on the human health and are also not very cost effective. Moreover, emergence of multidrug resistance (MDR) phenomenon has also compromised their activities. OBJECTIVE: Hence there is an urgent need to search novel drugs and compounds from natural sources having lesser side effects which have proved to be vital and widely used nowadays...
September 19, 2016: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/27634359/phytochemicals-as-effective-quorum-quenchers-against-bacterial-communication
#11
Subramaniyan S, Divyasree S, Sandhia G S
BACKGROUND: Quorum sensing or the bacterial information flow in an orchestrated manner is an essential feature of many pathogenic bacteria. Quorum quenching molecules (QQ) can inhibit the growth of such bacteria. OBJECTIVE: The purpose of this study is to evaluate the potential of plant extracts as quorum quenchers and monitor the recent patents. METHODS: Many available reports and patents are on synthetic ligand molecules or even compounds isolated from cyanobacteria (Honaucin A) and other microorganisms inhibiting quorum sensing molecules...
September 8, 2016: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/27634358/plant-volatile-genomics-recent-developments-and-putative-applications-in-agriculture
#12
Pratapbhanu Bhadoria, Ishita Paul, Adinpunya Mitra
Investigation of plant volatiles and their biosynthetic pathways is a relatively new field in plant biochemistry. The diversity of structure and function of these volatiles is gradually being understood. However, the great diversity of volatile biochemicals plants emit through different parts plays numerous roles in stress resistance and other ecological interactions. From an agronomic point of view, regulation volatile production in crop plants may lead to desirable changes in plant defence, pollinator attraction and post-harvest qualities...
September 8, 2016: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/27585483/recent-inventions-and-trends-in-algal-biofuels-research
#13
Ramkrishna Sen, Ankush Karemore, Manoranjan Nayak
BACKGROUND: In recent times, when energy crisis compounded by global warming and climate change is receiving worldwide attention, the emergence of algae, as a better feedstock for third-generation biofuels than energy crops or plants, holds lots of promises. Compared to conventional biofuels feedstocks, algae offer several advantages and can alone produce the significant amount of biofuels sustainably in a shorter period to fulfill the rising demand. OBJECTIVE: Towards commercialisation, there have been numerous efforts put into for the development of algae-derived biofuel...
August 30, 2016: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/27585482/bio-electricity-generation-using-jatropha-oil-seed-cake
#14
Hifjur Raheman, Debasish Padhee
BACKGROUND: Handling of Jatropha seed cake after extraction of oil is essential as it contains toxic materials which create environmental pollution. METHODS: The goal of this work is complete utilisation of Jatropha seeds. For this Jatropha oil was used for producing biodiesel and the byproduct Jatropha seed cake was gasified to produce producer gas. Both biodiesel and producer gas were used to generate electricity. To achieve this, a system comprising gasifier, briquetting machine, diesel engine and generator was developed...
August 30, 2016: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/27494735/preparation-and-biochemical-property-of-penicillin-g-amidase-loaded-alginate-and-alginate-chitosan-hydrogel-beads
#15
Mira Debnath, Neh Nupur, Ashish Itbhu
BACKGROUND: Penicillin G amidase (PGA) (EC 3.5.1.11) are group of enzymes that mainly involved in synthesis of semi-synthetic β-lactam antibiotics. Soluble PGA is costly and lacks long term operational stability. OBJECTIVE: Present work aim to do comparative Biochemical Property study of PGA enzyme immobilized in two hydro-gel beads - Ca-alginate and alginate+chitosan hybrid and morphologically characterised by SEM. METHODS: PGA immobilized in alginate+chitosan shows high pH and thermal stability...
August 5, 2016: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/27494734/inactivation-of-pseudomonas-aeruginosa-by-chitosan-coated-iron-oxide-nanoparticles
#16
Sirshendu De, Munmun Mukherjee
BACKGROUND: Pseudomonas aeruginosa is one of the potent opportunistic pathogens associated with respiratory and urinary tract infection. The bacterium owes its pathogenicity due to the intrinsic resistance to antibiotics and disinfectants. OBJECTIVE: The present study is focused on the synthesis of antibacterial chitosan coated iron oxide nanoparticles for rapid inactivation of Pseudomonas aeruginosa. We have discussed the relevant patents on synthesis and antibacterial potential of metallic nanoparticles and chitosan...
August 5, 2016: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/27494733/molecular-genetic-approaches-for-environmental-stress-tolerant-crop-plants-progress-and-prospects
#17
Ranjeet Kaur, Ananta Kumar Ghosh, Rupam Kumar Bhunia
Global food security is threatened by the severe environmental conditions that have reduced the worldwide crop yield. Plants possess inherent mechanisms to cope with the initial stress phase but to ensure their survival through harsh climate, the intervention of genetic engineering is desirable. Elucidation of genetic loci and deciphering the underlying mechanisms that confer tolerance to plants against stressful conditions followed by its successful introgression into elite, high-yielding crop varieties can be an effective way to engineer the crops for increasing productivity...
August 5, 2016: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/27494086/molecular-genetic-approaches-for-environmental-stress-tolerant-crop-plants-progress-and-prospects
#18
Ranjeet Kaur, Ananta Kumar Ghosh, Rupam Kumar Bhunia
Global food security is threatened by the severe environmental conditions that have reduced the worldwide crop yield. Plants possess inherent mechanisms to cope with the initial stress phase but to ensure their survival through harsh climate, the intervention of genetic engineering is desirable. Elucidation of genetic loci and deciphering the underlying mechanisms that confer tolerance to plants against stressful conditions followed by its successful introgression into elite, high-yielding crop varieties can be an effective way to engineer the crops for increasing productivity...
August 5, 2016: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/27494033/inactivation-of-pseudomonas-aeruginosa-by-chitosan-coated-iron-oxide-nanoparticles
#19
Sirshendu De, Munmun Mukherjee
BACKGROUND: Pseudomonas aeruginosa is one of the potent opportunistic pathogens associated with respiratory and urinary tract infection. The bacterium owes its pathogenicity due to the intrinsic resistance to antibiotics and disinfectants. OBJECTIVE: The present study is focused on the synthesis of antibacterial chitosan coated iron oxide nanoparticles for rapid inactivation of Pseudomonas aeruginosa. We have discussed the relevant patents on synthesis and antibacterial potential of metallic nanoparticles and chitosan...
August 5, 2016: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/27468815/recent-advances-in-ligand-and-structure-based-screening-of-potent-quorum-sensing-inhibitors-against-bacterial-virulence-induced-antibiotic-resistance
#20
Sisir Nandi
Antibiotic resistance is a growing threat in the treatment of bacterial diseases. Bacterial invasion and its virulence can cause damage to the host cells via quorum sensing mechanism which is responsible for the intercellular communication among bacteria that regulates expression of many genes. Quorum sensing (QS) is one of the reasons for producing resistance to the antibiotic treatment against bacterial virulence. Researchers have been battling to develop promising inhibitors active against quorum sensing mechanism to control bacterial virulence...
July 28, 2016: Recent Patents on Biotechnology
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